Detailed information for compound 1214209

Basic information

Technical information
  • TDR Targets ID: 1214209
  • Name: 6H-benzo[b][1]benzothiepin-5-one
  • MW: 226.294 | Formula: C14H10OS
  • H donors: 0 H acceptors: 1 LogP: 3.44 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Cc2ccccc2Sc2c1cccc2
  • InChi: 1S/C14H10OS/c15-12-9-10-5-1-3-7-13(10)16-14-8-4-2-6-11(12)14/h1-8H,9H2
  • InChiKey: IEIUIKHMVGQHBH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • dibenzo[b,f]thiepin-10(11H)-one
  • ZINC00346724
  • MLS000543737
  • SMR000162770
  • AE-641/00686014

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.012 0.0953
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0079
Echinococcus granulosus jumonji domain containing 1A 0.0047 0.0091 0.0091
Echinococcus multilocularis zinc finger protein Ran binding 0.0387 0.125 0.125
Onchocerca volvulus 0.0029 0.0029 0.0037
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0029 0.0226
Schistosoma mansoni regulator of G protein signaling 0.002 0.0001 0.0001
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0025 0.0018 0.0018
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0104 0.0104
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0025 0.0017 0.0046
Echinococcus granulosus Chromobox protein 3 0.0025 0.0015 0.0015
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0387 0.125 0.125
Brugia malayi hypothetical protein 0.0079 0.0199 0.0546
Plasmodium vivax acyl-CoA synthetase, putative 0.0073 0.018 0.0492
Brugia malayi hypothetical protein 0.002 0.0001 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0036 0.0053 0.0145
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0025 0.0018 0.0025
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.1047 0.3499 1
Trypanosoma cruzi ISWI complex protein 0.0049 0.0099 0.0789
Leishmania major hypothetical protein, conserved 0.0029 0.0029 0.0226
Brugia malayi jmjC domain containing protein 0.037 0.1191 0.3275
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0264 0.0752
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.0587 0.0587
Echinococcus granulosus axis inhibition protein axin 0.002 0.0001 0.0001
Plasmodium vivax ataxin-2 like protein, putative 0.0079 0.0199 0.0545
Onchocerca volvulus 0.0029 0.0029 0.0038
Trypanosoma brucei hypothetical protein, conserved 0.0387 0.125 1
Brugia malayi Protein cec-1. 0.0025 0.0015 0.0042
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0193 0.0587 0.0587
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0015 0.0021
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0001 0.0001
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.012 0.0327
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0025 0.0017 0.0046
Loa Loa (eye worm) hypothetical protein 0.0178 0.0537 0.1475
Toxoplasma gondii PHD-finger domain-containing protein 0.0094 0.0252 0.069
Brugia malayi RNA binding protein 0.0069 0.0166 0.0455
Loa Loa (eye worm) hypothetical protein 0.0058 0.0127 0.0349
Trichomonas vaginalis Heterochromatin protein, putative 0.0025 0.0015 0.0021
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0029 0.008
Mycobacterium tuberculosis Probable hydrolase 0.0029 0.0029 0.0081
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0035 0.0035
Trypanosoma cruzi DNA polymerase eta, putative 0.0025 0.0017 0.0127
Schistosoma mansoni DNA polymerase eta 0.0036 0.0053 0.0053
Schistosoma mansoni inositol monophosphatase 0.0037 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0031 0.0035 0.0035
Mycobacterium ulcerans esterase/lipase LipP 0.0029 0.0029 0.0081
Echinococcus granulosus lysine specific demethylase 5A 0.0182 0.0551 0.0551
Echinococcus granulosus zinc finger protein 0.0063 0.0146 0.0146
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0093 0.0249 0.0708
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0015 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.008
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0192 0.0587 0.0587
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0029 0.0224
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0025 0.0017 0.0046
Giardia lamblia Fructose-bisphosphate aldolase 0.2143 0.7235 1
Schistosoma mansoni hypothetical protein 0.0031 0.0035 0.0035
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0101 0.0276
Treponema pallidum fructose-bisphosphate aldolase 0.2143 0.7235 1
Echinococcus multilocularis geminin 0.018 0.0546 0.0546
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0085 0.0219 0.0603
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0001 0.000008273
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0029 0.0029 0.0081
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0387 0.125 1
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0002 0.0002
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0196 0.0601 0.4806
Echinococcus multilocularis voltage gated potassium channel 0.0029 0.0031 0.0031
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0035 0.0096
Brugia malayi Cyclic-nucleotide gated cation channel 0.0025 0.0018 0.0049
Brugia malayi F/Y-rich N-terminus family protein 0.004 0.0069 0.0188
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0225 0.0698 0.1885
Brugia malayi M-phase phosphoprotein, mpp8 0.0025 0.0015 0.0042
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0093 0.0249 0.0708
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0025 0.0017 0.0046
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0042
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0001 0.0001
Echinococcus multilocularis SWI:SNF matrix associated 0.1087 0.3638 0.3638
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0493
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0025 0.0017 0.0046
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0029 0.008
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.012 0.012
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0029 0.004
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0025 0.0017 0.0046
Leishmania major cytochrome p450-like protein 0.005 0.0101 0.0799
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0029 0.0029 0.008
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0025 0.0018 0.0018
Loa Loa (eye worm) MBCTL1 0.0058 0.0127 0.0349
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1087 0.3638 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0079
Mycobacterium tuberculosis Probable lipase LipD 0.0029 0.0029 0.0081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0056 0.0121 0.0121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0029 0.008
Schistosoma mansoni TRABID protein (C64 family) 0.0387 0.125 0.125
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0493
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0029 0.0029 0.008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0652 0.2153 0.5918
Loa Loa (eye worm) hypothetical protein 0.0387 0.125 0.3435
Schistosoma mansoni inositol monophosphatase 0.0037 0.0058 0.0058
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0029 0.0029 0.0077
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0192 0.0587 0.4696
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.008
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0029 0.0224
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0031 0.0031
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0103 0.0284 0.0767
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0058 0.0456
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0025 0.0017 0.013
Echinococcus granulosus Zinc finger RanBP2 type 0.0387 0.125 0.125
Trichomonas vaginalis set domain proteins, putative 0.0742 0.246 0.34
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0048 0.0094 0.0257
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0023 0.0008 0.0008
Brugia malayi YY1-associated factor 2 0.0387 0.125 0.3435
Brugia malayi chromobox protein homolog 3 0.0085 0.0219 0.0603
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0043 0.0079 0.0109
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0017 0.0044
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0025 0.0017 0.013
Entamoeba histolytica acyl-coA synthetase, putative 0.0098 0.0264 0.0364
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0029 0.0224
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0025 0.0018 0.0049
Echinococcus granulosus muscleblind protein 0.0934 0.3115 0.3115
Loa Loa (eye worm) PHD-finger family protein 0.0067 0.0158 0.0434
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0055 0.012 0.012
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0029 0.004
Entamoeba histolytica hypothetical protein 0.0025 0.0015 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.2143 0.7235 1
Onchocerca volvulus 0.0029 0.0029 0.0037
Loa Loa (eye worm) CYP4Cod1 0.005 0.0101 0.0276
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0001 0.0001
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0029 0.0078
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0025 0.0017 0.0046
Brugia malayi jmjC domain containing protein 0.0047 0.0091 0.0249
Brugia malayi Cytochrome P450 family protein 0.005 0.0101 0.0276
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0058 0.0079
Echinococcus multilocularis muscleblind protein 0.0934 0.3115 0.3115
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0029 0.0029 0.0029
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.012 0.0953
Onchocerca volvulus 0.0066 0.0157 0.0391
Echinococcus multilocularis Chromobox protein 3 0.0025 0.0015 0.0015
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0053 0.0417
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0029 0.0029 0.0079
Trypanosoma brucei protein kinase, putative 0.0055 0.012 0.0953
Plasmodium vivax hypothetical protein, conserved 0.0094 0.0252 0.069
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0001 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0387 0.125 1
Trypanosoma cruzi cytochrome P450, putative 0.005 0.0101 0.0799
Loa Loa (eye worm) hypothetical protein 0.0148 0.0437 0.1202
Plasmodium falciparum phd finger protein, putative 0.0094 0.0252 0.069
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0156
Echinococcus granulosus expressed protein 0.0397 0.1286 0.1286
Schistosoma mansoni methyl-cpg binding protein mbd 0.0055 0.0119 0.0119
Loa Loa (eye worm) cytochrome P450 0.0025 0.0017 0.0046
Brugia malayi PHD-finger family protein 0.0094 0.0252 0.0691
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0587 0.1677
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0025 0.0017 0.0046
Schistosoma mansoni lamin 0.0029 0.0029 0.0029
Loa Loa (eye worm) RGS-3 protein 0.002 0.0001 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0098 0.0264 0.0752
Echinococcus multilocularis PHD finger protein rhinoceros 0.0094 0.0252 0.0251
Trypanosoma brucei ISWI complex protein 0.0049 0.0099 0.0789
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0025 0.0018 0.0018
Brugia malayi Thioredoxin reductase 0.0041 0.007 0.0193
Brugia malayi Pre-SET motif family protein 0.0652 0.2153 0.5918
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0025 0.0018 0.0018
Echinococcus multilocularis tumor protein p63 0.2365 0.7992 0.7992
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.2143 0.7235 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0015 0.0021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0035 0.0035
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0387 0.125 0.125
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0001 0.0001
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1087 0.3638 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0072 0.0072
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0029 0.0029 0.008
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0029 0.0029 0.0034
Brugia malayi Bromodomain containing protein 0.0102 0.0278 0.0763
Toxoplasma gondii ran binding protein 0.0387 0.125 0.3434
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0104 0.0103
Brugia malayi cytochrome P450 0.0025 0.0017 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0025 0.0017 0.0046
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0199 0.1586
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0025 0.0015 0.004
Brugia malayi N-terminal motif family protein 0.0225 0.0698 0.1919
Schistosoma mansoni regulator of G protein signaling 0.002 0.0001 0.0001
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0047 0.0091 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0166 0.0166
Schistosoma mansoni z-protein (S1r protein) 0.0031 0.0038 0.0038
Mycobacterium tuberculosis Probable esterase LipL 0.0029 0.0029 0.0081
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0015 0.0041
Echinococcus granulosus sodium channel protein 0.0196 0.0601 0.0601
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.012 0.0953
Loa Loa (eye worm) CHromoDomain protein family member 0.0031 0.0036 0.0099
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0098 0.0264 0.0709
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0166 0.0166
Mycobacterium ulcerans hypothetical protein 0.0098 0.0264 0.0752
Loa Loa (eye worm) brahma associated protein 0.1087 0.3638 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0199 0.0545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.2143 0.7235 1
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0029 0.0226
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0059 0.0131 0.0131
Schistosoma mansoni ap endonuclease 0.002 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0148 0.0437 0.0437
Plasmodium falciparum glutathione reductase 0.0041 0.007 0.0191
Onchocerca volvulus 0.0387 0.125 0.3408
Loa Loa (eye worm) hypothetical protein 0.0025 0.0018 0.0049
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0387 0.125 0.3435
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0264 0.2106
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0002 0.0006
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0091 0.0241 0.0624
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.012 0.0953
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0025 0.0017 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0001 0.0001
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0025 0.0018 0.0018
Brugia malayi Cytochrome P450 family protein 0.0025 0.0017 0.0046
Echinococcus granulosus dna polymerase eta 0.0036 0.0053 0.0053
Echinococcus multilocularis JmjC domain containing protein 4 0.0047 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0048 0.0096 0.0264
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0166 0.0166
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.007 0.0556
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0015 0.004
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0025 0.0017 0.0046
Leishmania major hypothetical protein, conserved 0.0387 0.125 1
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.012 0.0165
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0025 0.0017 0.013
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0025 0.0017 0.0046
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0096 0.026 0.0714
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0047 0.0091 0.0247
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0029 0.008
Leishmania major hypothetical protein, conserved 0.0047 0.0091 0.0721
Loa Loa (eye worm) hypothetical protein 0.0124 0.0353 0.097
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0058 0.0456
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0093 0.0249 0.0665
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0025 0.0017 0.0046
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0025 0.0018 0.0018
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0029 0.0224
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0029 0.004
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0055 0.0119 0.0118
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0264 0.0725
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0053 0.0112 0.0112
Brugia malayi intermediate filament protein 0.0029 0.0029 0.0078
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0091 0.0249
Echinococcus granulosus fetal alzheimer antigen falz 0.0073 0.0179 0.0179
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0094 0.0222
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0093 0.0249 0.0708
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0058 0.0156
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0042
Echinococcus granulosus peregrin 0.0102 0.0278 0.0277
Loa Loa (eye worm) hypothetical protein 0.0138 0.04 0.1099
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0001 0.0001
Brugia malayi SET domain containing protein 0.0028 0.0027 0.0074
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0042
Echinococcus granulosus tumor protein p63 0.2365 0.7992 0.7992
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0025 0.0015 0.0015
Schistosoma mansoni acetyl-CoA synthetase 0.0029 0.0029 0.0029
Echinococcus granulosus hyperpolarization activated cyclic 0.0025 0.0018 0.0018
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.018 0.0511
Mycobacterium tuberculosis Probable oxidoreductase 0.0103 0.0284 0.0809
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0002 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0131 0.0379 0.1041
Schistosoma mansoni hypothetical protein 0.0067 0.0158 0.0158
Schistosoma mansoni voltage-gated potassium channel 0.0062 0.0144 0.0144
Onchocerca volvulus 0.0387 0.125 0.3408
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0025 0.0017 0.0046
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0264 0.0725
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0015 0.0021
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0104 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0148 0.0437 0.0437
Echinococcus granulosus voltage gated potassium channel 0.0029 0.0031 0.0031
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0001 0.0001
Brugia malayi beta-lactamase family protein 0.0029 0.0029 0.0079
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0001 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0148 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0001
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0387 0.125 0.3435
Schistosoma mansoni chromobox protein 0.0025 0.0015 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0002 0.0002
Leishmania major hypothetical protein, conserved 0.0049 0.0099 0.0789
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.2143 0.7235 1
Echinococcus granulosus L aminoadipate semialdehyde 0.017 0.0511 0.0511
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0015 0.0021
Schistosoma mansoni hypothetical protein 0.0055 0.012 0.012
Echinococcus multilocularis nmda type glutamate receptor 0.0071 0.0172 0.0172
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0029 0.0029 0.008
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0029 0.0029 0.008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0055 0.012 0.012
Schistosoma mansoni regulator of G protein signaling 0.002 0.0001 0.0001
Echinococcus multilocularis lysine specific demethylase 6a 0.0047 0.0091 0.0091
Brugia malayi PHD-finger family protein 0.0037 0.0057 0.0156
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0025 0.0017 0.0046
Loa Loa (eye worm) hypothetical protein 0.0387 0.125 0.3435
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0015 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0015 0.0021
Plasmodium vivax acetyl-CoA synthetase, putative 0.0029 0.0029 0.0077
Echinococcus multilocularis lysine specific demethylase 5A 0.0176 0.053 0.053
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0029 0.0029 0.0079
Plasmodium falciparum heterochromatin protein 1 0.0025 0.0015 0.004
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0103 0.0284 0.0809
Schistosoma mansoni axis inhibition protein axin 0.002 0.0001 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0091 0.0249
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0025 0.0018 0.0018
Brugia malayi beta-lactamase 0.0029 0.0029 0.0079
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0079
Trichomonas vaginalis hypothetical protein 0.0025 0.0015 0.0021
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0264 0.2106
Echinococcus multilocularis nmda type glutamate receptor 0.009 0.0238 0.0238
Brugia malayi brahma associated protein 60 kDa 0.1087 0.3638 1
Leishmania major hypothetical protein, conserved 0.0387 0.125 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0029 0.0029 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0042
Echinococcus multilocularis regulator of G protein signaling 7 0.0031 0.0038 0.0037
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0001 0.0001
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0036 0.0097
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0387 0.125 1
Brugia malayi jmjC domain containing protein 0.0047 0.0091 0.0249
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.2143 0.7235 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0002 0.0002
Echinococcus multilocularis chromobox protein 1 0.0151 0.0445 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0015 0.0021
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0029 0.0029 0.008
Schistosoma mansoni chromobox protein 0.0151 0.0445 0.0445
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0029 0.0029 0.008
Echinococcus multilocularis neuropeptide s receptor 0.0495 0.1617 0.1617
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0025 0.0017 0.0046
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0047 0.0091 0.0721
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.017 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0079
Schistosoma mansoni brg-1 associated factor 0.1087 0.3638 0.3638
Echinococcus multilocularis peregrin 0.0102 0.0278 0.0277
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0166 0.0473
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0127 0.0127
Schistosoma mansoni phd/f-box containing protein 0.0047 0.0091 0.0091
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0029 0.0034
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0031 0.0036 0.0281
Onchocerca volvulus 0.0387 0.125 0.3408
Mycobacterium tuberculosis Conserved protein 0.0029 0.0029 0.0081
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0035 0.0096
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.005 0.0101 0.0285
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0493
Mycobacterium ulcerans hypothetical protein 0.0029 0.0029 0.0081
Brugia malayi Muscleblind-like protein 0.0934 0.3115 0.8562
Brugia malayi PXA domain containing protein 0.002 0.0001 0.0001
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0029 0.0224
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0025 0.0018 0.0018
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0015 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0587 0.1677
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0048 0.0094 0.0257
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0058 0.0163
Schistosoma mansoni regulator of G protein signaling 0.002 0.0001 0.0001
Trypanosoma brucei trypanothione reductase 0.0041 0.007 0.0556
Trypanosoma brucei cytochrome P450, putative 0.005 0.0101 0.0799
Schistosoma mansoni hypothetical protein 0.0094 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0031 0.0035 0.0035
Echinococcus multilocularis ring and YY1 binding protein 0.0387 0.125 0.125
Schistosoma mansoni regulator of G protein signaling 0.0031 0.0038 0.0038
Echinococcus multilocularis sodium channel protein 0.0196 0.0601 0.0601
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0029 0.0029 0.0081
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0015 0.004
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0029 0.0031 0.0084
Mycobacterium ulcerans lipase LipD 0.0029 0.0029 0.0081
Loa Loa (eye worm) RNA binding protein 0.0069 0.0166 0.0455
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0029 0.004
Onchocerca volvulus 0.0098 0.0264 0.0686
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.2143 0.7235 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0015 0.0021
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.0238 0.0238
Onchocerca volvulus 0.0029 0.0029 0.0038
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0048 0.0094 0.0129
Loa Loa (eye worm) helicase 0.0025 0.0015 0.0042
Loa Loa (eye worm) PHD-finger family protein 0.0094 0.0252 0.0691
Echinococcus granulosus beta LACTamase domain containing family member 0.0029 0.0029 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0025 0.0017 0.0046
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0031 0.0036 0.0036
Echinococcus granulosus GPCR family 2 0.0031 0.0035 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0264 0.0725
Loa Loa (eye worm) heterochromatin protein 1 0.0151 0.0445 0.1224
Onchocerca volvulus 0.0742 0.246 0.6748
Echinococcus granulosus lysine specific demethylase 6a 0.0047 0.0091 0.0091
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0001 0.0001
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0048 0.0094 0.0267
Echinococcus granulosus SWI:SNF matrix associated 0.1087 0.3638 0.3638
Schistosoma mansoni chromobox protein 0.0151 0.0445 0.0445
Trichomonas vaginalis chromobox protein, putative 0.0151 0.0445 0.0615
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0015 0.0021
Onchocerca volvulus 0.1087 0.3638 1
Trypanosoma cruzi hypothetical protein, conserved 0.0387 0.125 1
Loa Loa (eye worm) inositol-1 0.0037 0.0058 0.0158
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0056 0.0121 0.0331
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0084
Toxoplasma gondii LsmAD domain-containing protein 0.0079 0.0199 0.0545
Echinococcus multilocularis L aminoadipate semialdehyde 0.017 0.0511 0.0511
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0219 0.0303
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0001 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0015 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0025 0.0017 0.0046
Leishmania major phosphopantetheinyl transferase-like protein 0.0048 0.0094 0.0748
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.012 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0001 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0073 0.018 0.0511
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0166 0.0165
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0058 0.0058
Echinococcus granulosus glutamate receptor NMDA 0.0067 0.0161 0.0161
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.008
Loa Loa (eye worm) hypothetical protein 0.0098 0.0264 0.0725
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0025 0.0017 0.0046
Echinococcus granulosus hyperpolarization activated cyclic 0.0025 0.0018 0.0018
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0199 0.1586
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0001
Brugia malayi SWIB/MDM2 domain containing protein 0.1087 0.3638 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0001 0.0001
Schistosoma mansoni phosphatidylserine receptor 0.0047 0.0091 0.0091
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0029 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0056 0.0121 0.0121
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0025 0.0018 0.0025
Onchocerca volvulus Alhambra homolog 0.0094 0.0252 0.0652
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0587 0.1677
Toxoplasma gondii aldehyde dehydrogenase 0.0192 0.0587 0.1613
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0025 0.0017 0.0046
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0387 0.125 1
Brugia malayi PHD-finger family protein 0.008 0.0205 0.0563
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0078
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0001
Echinococcus multilocularis Chromo domain 0.0025 0.0015 0.0015
Echinococcus multilocularis muscleblind protein 1 0.0934 0.3115 0.3115
Echinococcus granulosus chromobox protein 1 0.0151 0.0445 0.0445
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0121 0.0121
Leishmania major hypothetical protein, conserved 0.0387 0.125 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0079
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0058 0.6092
Echinococcus multilocularis lamin 0.0029 0.0029 0.0028
Trypanosoma brucei PAB1-binding protein , putative 0.0079 0.0199 0.1586
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0059 0.0131 0.036
Loa Loa (eye worm) hypothetical protein 0.0051 0.0104 0.0284
Schistosoma mansoni hypothetical protein 0.0066 0.0156 0.0156
Brugia malayi mbt repeat family protein 0.0051 0.0104 0.0284
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.007 0.0191
Mycobacterium leprae conserved hypothetical protein 0.0029 0.0029 0.0035
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0001 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0047 0.0091 0.0249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0098 0.0264 0.0752
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0079
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0002 0.0006
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0031 0.0036 0.0281
Leishmania major hypothetical protein, conserved 0.0387 0.125 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0104 0.0104
Trichomonas vaginalis chromobox protein, putative 0.0091 0.0241 0.0333
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0001 0.0002
Giardia lamblia Kinase, NEK 0.002 0.000000013348 0.000000018449
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0104 0.0243
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.0587 0.0587
Schistosoma mansoni cytochrome P450 0.0025 0.0017 0.0017
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.012 0.0165
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0029 0.0029 0.008
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0094 0.0252 0.0252
Echinococcus granulosus regulator of G protein signaling 7 0.0031 0.0038 0.0037
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.017 0.0511 0.1404
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0001 0.0001
Brugia malayi Inositol-1 0.0037 0.0058 0.0158
Loa Loa (eye worm) hypothetical protein 0.0036 0.0053 0.0145
Loa Loa (eye worm) bromodomain containing protein 0.0057 0.0125 0.0344
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0387 0.125 1
Echinococcus granulosus cytochrome P450 2K1 0.0025 0.0017 0.0017
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0025 0.0017 0.0046
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.004
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0015 0.002
Schistosoma mansoni transcription factor LCR-F1 0.0055 0.012 0.012
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0079
Loa Loa (eye worm) hypothetical protein 0.0387 0.125 0.3435
Loa Loa (eye worm) hypothetical protein 0.0346 0.1111 0.3054
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0025 0.0017 0.0046
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0387 0.125 0.3435
Loa Loa (eye worm) hypothetical protein 0.0098 0.0264 0.0725
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0127 0.0127
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0264 0.2106
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0029 0.0078
Schistosoma mansoni hypothetical protein 0.0031 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0031 0.0038 0.0103
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1087 0.3638 1
Brugia malayi MH2 domain containing protein 0.0293 0.093 0.2556
Schistosoma mansoni hypothetical protein 0.0387 0.125 0.125
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0015 0.002
Echinococcus granulosus jumonji domain containing protein 0.0131 0.0377 0.0377
Onchocerca volvulus 0.0029 0.0029 0.0037
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0073 0.0179 0.0179
Echinococcus multilocularis chromobox protein 2 0.0025 0.0015 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0029 0.0029
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0073 0.018 0.0241
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0264 0.0752
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0058 0.0058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0166 0.0473
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0166 0.0455
Entamoeba histolytica hypothetical protein 0.0025 0.0015 0.002
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0025 0.0017 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.025 0.025
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0079
Brugia malayi hypothetical protein 0.002 0.0001 0.0001
Brugia malayi Cytochrome P450 family protein 0.005 0.0101 0.0276
Leishmania major cytochrome p450-like protein 0.0025 0.0017 0.013
Toxoplasma gondii PHD-finger domain-containing protein 0.0094 0.0252 0.069
Schistosoma mansoni RNA binding protein 0.0387 0.125 0.125
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0058 0.0456
Brugia malayi jmjC domain containing protein 0.0047 0.0091 0.0249
Schistosoma mansoni hypothetical protein 0.0049 0.0099 0.0099
Echinococcus granulosus methyl CpG binding domain protein 2 0.0055 0.0119 0.0118
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0493
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0193 0.0587 0.0587
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0056 0.0121 0.0331
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0029 0.0029 0.0034
Trypanosoma cruzi ISWI complex protein 0.0049 0.0099 0.0789
Echinococcus granulosus neuropeptide receptor A26 0.0495 0.1617 0.1617
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0025 0.0017 0.0046
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0025 0.0017 0.0046
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0059 0.0131 0.0131
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0025 0.0017 0.0046
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0059 0.0131 0.036
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.008
Echinococcus granulosus tar DNA binding protein 0.0069 0.0166 0.0165
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0025 0.0017 0.0046
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0101 0.0276
Echinococcus multilocularis zinc finger protein 0.0063 0.0146 0.0146
Echinococcus multilocularis beta LACTamase domain containing family member 0.0029 0.0029 0.0029
Mycobacterium tuberculosis Probable reductase 0.0093 0.0249 0.0708
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1087 0.3638 0.3638
Loa Loa (eye worm) hypothetical protein 0.0094 0.0252 0.0691
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.012 0.0166
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0029 0.0029 0.0077
Loa Loa (eye worm) beta-lactamase 0.0029 0.0029 0.0079
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0025 0.0018 0.0018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0029 0.0029 0.0079
Echinococcus granulosus zinc finger protein Ran binding 0.0387 0.125 0.125
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0029 0.0224
Entamoeba histolytica hypothetical protein 0.0055 0.012 0.0165
Schistosoma mansoni axis inhibition protein axin 0.002 0.0001 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0056 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0387 0.125 0.3435
Echinococcus multilocularis regulator of G protein signaling 7 0.0031 0.0038 0.0037
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0127 0.0127
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0025 0.0017 0.0046
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0043 0.0079 0.0109
Brugia malayi hypothetical protein 0.0051 0.0104 0.0285
Echinococcus multilocularis phd:f box containing protein 0.0047 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.018 0.0546 0.0546
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.0624 0.0624
Brugia malayi jmjC domain containing protein 0.0047 0.0091 0.0249
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0001 0.0001
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.012 0.012
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0047 0.0091 0.0247
Leishmania major hypothetical protein, conserved 0.0079 0.0199 0.1586
Echinococcus multilocularis hyperpolarization activated cyclic 0.0025 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0047 0.0091 0.0249
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0029 0.0226
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0387 0.125 0.3434
Schistosoma mansoni zinc finger protein 0.0049 0.0099 0.0099
Mycobacterium tuberculosis Conserved protein 0.0029 0.0029 0.0081
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.025 0.0685
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0001 0.0001
Schistosoma mansoni methyl-cpg binding protein mbd 0.0055 0.0119 0.0119
Leishmania major trypanothione reductase 0.0041 0.007 0.0556
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0025 0.0015 0.004
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0127 0.0127
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0015 0.0021
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0029 0.0029 0.0224
Brugia malayi Cytochrome P450 family protein 0.0066 0.0157 0.0432
Echinococcus granulosus ring and YY1 binding protein 0.0387 0.125 0.125
Echinococcus multilocularis lamin dm0 0.0029 0.0029 0.0028
Brugia malayi TAR-binding protein 0.0069 0.0166 0.0455
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.0624 0.0624
Plasmodium vivax glutathione reductase, putative 0.0041 0.007 0.0191
Schistosoma mansoni voltage-gated potassium channel 0.0062 0.0144 0.0144
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0025 0.0017 0.0046
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0192 0.0587 0.1677
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1087 0.3638 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0293 0.093 0.2556
Brugia malayi beta-lactamase family protein 0.0029 0.0029 0.0079
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.012 0.0953
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0029 0.0029 0.0077
Schistosoma mansoni jumonji domain containing protein 0.0047 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0042
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0015 0.0021
Schistosoma mansoni hypothetical protein 0.1087 0.3638 0.3638
Schistosoma mansoni hypothetical protein 0.0031 0.0036 0.0036
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0051 0.0051
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0048 0.0094 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0001
Toxoplasma gondii propionate-CoA ligase 0.0029 0.0029 0.0077
Echinococcus multilocularis glutamate receptor NMDA 0.0067 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0079 0.0199 0.0546
Mycobacterium ulcerans acetyl-CoA synthetase 0.0029 0.0029 0.008
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0029 0.0029 0.008
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0025 0.0018 0.0018
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0025 0.0015 0.0042
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0104 0.0103
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0029 0.008
Onchocerca volvulus 0.0029 0.0029 0.0037
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0058 0.0456
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0096 0.026 0.0714
Onchocerca volvulus 0.0025 0.0015 0.000000036848
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0104 0.0103
Echinococcus multilocularis neuropeptide receptor A26 0.0495 0.1617 0.1617
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0121 0.0121
Trichomonas vaginalis esterase, putative 0.0029 0.0029 0.004
Mycobacterium ulcerans beta-lactamase 0.0029 0.0029 0.0081
Echinococcus multilocularis expressed protein 0.0397 0.1286 0.1286
Trichomonas vaginalis chromobox protein, putative 0.0091 0.0241 0.0333
Brugia malayi brahma associated protein 60 kDa 0.1087 0.3638 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0001 0.0001
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0156 0.0428
Plasmodium falciparum thioredoxin reductase 0.0041 0.007 0.0191
Plasmodium vivax SET domain protein, putative 0.0093 0.025 0.0685
Toxoplasma gondii ABC1 family protein 0.0029 0.0029 0.0078
Mycobacterium tuberculosis Conserved protein 0.0029 0.0029 0.0081
Loa Loa (eye worm) hypothetical protein 0.0934 0.3115 0.8562
Echinococcus granulosus PHD finger protein rhinoceros 0.0094 0.0252 0.0251
Trypanosoma cruzi WLM domain containing protein, putative 0.0387 0.125 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0031 0.0036 0.0036
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0001 0.0001
Echinococcus multilocularis 0.0025 0.0017 0.0017
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0029 0.0224
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0048 0.0094 1
Brugia malayi Valyl-tRNA synthetase 0.0025 0.0015 0.0042
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0044 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0219 0.0303
Mycobacterium tuberculosis Probable dehydrogenase 0.0093 0.0249 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0135 0.0187
Schistosoma mansoni hypothetical protein 0.0035 0.0051 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0166 0.0166
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.008
Echinococcus granulosus chromobox protein 2 0.0025 0.0015 0.0015
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0035 0.0096
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0387 0.125 1
Schistosoma mansoni fusion 0.0387 0.125 0.125
Brugia malayi jmjC domain containing protein 0.0182 0.0551 0.1513
Echinococcus multilocularis SWI:SNF matrix associated 0.1087 0.3638 0.3638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0166 0.0473
Schistosoma mansoni glutamate receptor NMDA 0.0077 0.0194 0.0194
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0073 0.0179 0.0179
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0199 0.0545
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0029 0.0078
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0001 0.0001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0116 0.0326 0.0326
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0015 0.0021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0182 0.0551 0.0551
Schistosoma mansoni hypothetical protein 0.0311 0.0993 0.0993
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0072 0.0072
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0029 0.004
Loa Loa (eye worm) hypothetical protein 0.0098 0.0264 0.0725
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0025 0.0017 0.0046
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0015 0.0021
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0058 0.0079
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.012 0.0329
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0094 0.0748
Trypanosoma cruzi cytochrome P450, putative 0.005 0.0101 0.0799
Brugia malayi PXA domain containing protein 0.002 0.0001 0.0001
Plasmodium vivax JmjC domain containing protein 0.0047 0.0091 0.0247
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0029 0.0031 0.0031
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0098 0.0264 0.0752
Leishmania major DNA polymerase eta, putative 0.0036 0.0053 0.0417
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0001 0.0001
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0029 0.0029 0.0039
Schistosoma mansoni chromobox protein 0.0025 0.0015 0.0015
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0104 0.0104
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0031 0.0036 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0025 0.0017 0.0046
Trypanosoma brucei DNA polymerase eta, putative 0.0036 0.0053 0.0417
Echinococcus multilocularis hyperpolarization activated cyclic 0.0025 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.1087 0.3638 0.3638
Schistosoma mansoni hypothetical protein 0.1087 0.3638 0.3638
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0029 0.0031 0.0031
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0098 0.0264 0.0709
Leishmania major hypothetical protein, conserved 0.0387 0.125 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0096 0.026 0.0714
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0029 0.0029 0.0029
Brugia malayi CHD4 protein 0.0031 0.0036 0.0099
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0001 0.0001
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0025 0.0018 0.0018
Echinococcus granulosus geminin 0.018 0.0546 0.0546
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0196 0.0601 0.0601
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0192 0.0587 0.0587
Brugia malayi Associated with TFs and helicases family protein 0.0025 0.0015 0.0042
Echinococcus granulosus chromobox protein 1 0.0151 0.0445 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0015 0.0021
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0048 0.0094 0.0257
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0017 0.013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0015 0.0021
Schistosoma mansoni zinc finger protein 0.0387 0.125 0.125
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0387 0.125 0.3435
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0104 0.0284
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0036 0.0097
Onchocerca volvulus 0.0051 0.0104 0.0243
Schistosoma mansoni ap endonuclease 0.002 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0025 0.0017 0.0046
Brugia malayi Heterochromatin protein 1 0.0151 0.0445 0.1224
Brugia malayi hypothetical protein 0.0025 0.0015 0.0042
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1087 0.3638 0.3638
Trichomonas vaginalis conserved hypothetical protein 0.1087 0.3638 0.5028
Schistosoma mansoni hypothetical protein 0.0025 0.0015 0.0015
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0029 0.0029 0.008
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0001
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0029 0.0029 0.008
Loa Loa (eye worm) hypothetical protein 0.017 0.0511 0.1404
Entamoeba histolytica acyl-CoA synthetase, putative 0.0098 0.0264 0.0364
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0387 0.125 0.3435
Echinococcus granulosus neuropeptide s receptor 0.0495 0.1617 0.1617
Echinococcus granulosus regulator of G protein signaling 7 0.0031 0.0038 0.0037
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0002 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.2143 0.7235 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0051 0.0051
Echinococcus granulosus phd:f box containing protein 0.0047 0.0091 0.0091
Loa Loa (eye worm) jmjC domain-containing protein 0.0182 0.0551 0.1513
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0058 0.0079
Onchocerca volvulus 0.0029 0.0029 0.0037
Leishmania major cytochrome p450-like protein 0.0025 0.0017 0.013
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0029 0.0224
Loa Loa (eye worm) hypothetical protein 0.0096 0.026 0.0714
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0116 0.0326 0.0326
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.012 0.0953
Onchocerca volvulus 0.0118 0.0334 0.088
Schistosoma mansoni hypothetical protein 0.0025 0.0017 0.0017
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0166 0.0455
Entamoeba histolytica hypothetical protein 0.0025 0.0015 0.002
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0029 0.0029 0.008
Entamoeba histolytica hypothetical protein 0.0055 0.012 0.0165
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0015 0.0021
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.2143 0.7235 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0035 0.0035
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0066 0.0157 0.0431
Chlamydia trachomatis SWIB complex protein 0.1087 0.3638 1
Plasmodium falciparum acyl-CoA synthetase 0.0073 0.018 0.0492
Schistosoma mansoni jumonji/arid domain-containing protein 0.0182 0.0551 0.0551
Echinococcus granulosus nmda type glutamate receptor 0.009 0.0238 0.0238
Loa Loa (eye worm) jmjC domain-containing protein 0.0194 0.0593 0.1629
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.012 0.012
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.1047 0.3499 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.007 0.0199
Schistosoma mansoni hypothetical protein 0.018 0.0546 0.0546
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.037 0.1191 0.1191
Echinococcus multilocularis musashi 0.0029 0.0029 0.0028
Brugia malayi glutathione reductase 0.0041 0.007 0.0193
Entamoeba histolytica hypothetical protein 0.0055 0.012 0.0165
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0025 0.0017 0.0046
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.037 0.1191 0.1191
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0029 0.0078
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0387 0.125 1
Mycobacterium leprae Probable lipase LipE 0.0029 0.0029 0.0035
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0017 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0015 0.0021
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0025 0.0017 0.0046
Brugia malayi MAP kinase sur-1 0.0055 0.012 0.0329
Echinococcus multilocularis chromobox protein 1 0.0151 0.0445 0.0445
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0085 0.0219 0.0563
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0001 0.0001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.025 0.025
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0183 0.0556 0.1588
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.012 0.012
Brugia malayi hypothetical protein 0.0055 0.012 0.0329
Echinococcus granulosus Chromo domain 0.0025 0.0015 0.0015
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0029 0.0029 0.0081
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1087 0.3638 1
Brugia malayi mbt repeat family protein 0.0051 0.0104 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0015 0.0021
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0015 0.004
Schistosoma mansoni protein phosphatase 2C 0.0047 0.0091 0.0091
Entamoeba histolytica acyl-CoA synthetase, putative 0.0098 0.0264 0.0364
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0025 0.0018 0.0018
Schistosoma mansoni bromodomain containing protein 0.0204 0.0627 0.0627
Trichomonas vaginalis chromobox protein, putative 0.0151 0.0445 0.0615
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1087 0.3638 1
Brugia malayi Pre-SET motif family protein 0.0093 0.025 0.0686
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0264 0.0752
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0029 0.0029 0.008
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0118 0.0334 0.0334
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0387 0.125 0.3408
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0048 0.0094 0.0267
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.012 0.0953
Echinococcus granulosus axis inhibition protein axin 0.002 0.0001 0.0001
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0048 0.0094 0.0257
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0166 0.0473
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0025 0.0017 0.0046
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0098 0.0264 0.0752
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0079
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.012 0.0165
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0042
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0029 0.0029 0.008
Echinococcus multilocularis jumonji domain containing protein 0.0131 0.0377 0.0377
Toxoplasma gondii cytochrome p450 superfamily protein 0.0025 0.0017 0.0045
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0058 0.0079
Echinococcus granulosus nmda type glutamate receptor 0.0071 0.0172 0.0172
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0047 0.0091 0.0721
Loa Loa (eye worm) transcription factor SMAD2 0.0293 0.093 0.2556
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.008
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0025 0.0017 0.0046
Trypanosoma cruzi WLM domain containing protein, putative 0.0387 0.125 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0073
Echinococcus multilocularis microtubule associated protein 2 0.2954 1 1
Brugia malayi AF-10 protein 0.0031 0.0036 0.0098
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0025 0.0017 0.0046
Onchocerca volvulus 0.0029 0.0029 0.0037
Plasmodium vivax heterochromatin protein 1, putative 0.0025 0.0015 0.004
Brugia malayi regulator of G-protein signaling egl-10 0.0031 0.0038 0.0103
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.007 0.0193
Echinococcus granulosus histone lysine methyltransferase setb 0.0148 0.0437 0.0437
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.2143 0.7235 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0031 0.0038 0.0103
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0098 0.0264 0.0752
Schistosoma mansoni zinc finger protein 0.0063 0.0146 0.0146
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0127 0.0349
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0044 0.0125
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0387 0.125 0.125
Loa Loa (eye worm) hypothetical protein 0.0066 0.0156 0.0428
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0053 0.0112 0.0112
Echinococcus multilocularis dna polymerase eta 0.0036 0.0053 0.0053
Loa Loa (eye worm) oxidoreductase 0.0029 0.0029 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0387 0.125 1
Entamoeba histolytica hypothetical protein 0.0048 0.0094 0.0129
Toxoplasma gondii thioredoxin reductase 0.0041 0.007 0.0191
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0025 0.0017 0.0046
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0493
Plasmodium falciparum JmjC domain-containing protein, putative 0.0047 0.0091 0.0247
Echinococcus multilocularis jumonji domain containing 1A 0.0047 0.0091 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0166 0.0166
Brugia malayi Bromodomain containing protein 0.0123 0.0352 0.0968
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0025 0.0017 0.0046
Loa Loa (eye worm) cytochrome P450 family protein 0.0066 0.0157 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0015 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0029 0.004
Loa Loa (eye worm) hypothetical protein 0.0934 0.3115 0.8562
Schistosoma mansoni jumonji domain containing protein 0.0306 0.0976 0.0976
Brugia malayi Bromodomain containing protein 0.0242 0.0756 0.2077
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0091 0.0249
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0015 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0228 0.0709 0.1947
Leishmania major DNA polymerase eta, putative 0.0025 0.0017 0.0127
Echinococcus multilocularis GPCR, family 2 0.0031 0.0035 0.0035
Trypanosoma brucei hypothetical protein, conserved 0.0387 0.125 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0015 0.0021
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0387 0.125 0.3434
Schistosoma mansoni cellular tumor antigen P53 0.0346 0.1111 0.1111
Schistosoma mansoni microtubule-associated protein tau 0.2954 1 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0098 0.0264 0.0752
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0093 0.0249 0.0708
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0031 0.0036 0.0097
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0103 0.0284 0.0809
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0079
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0166 0.0455
Onchocerca volvulus 0.0346 0.1111 0.3025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0121 0.0121
Schistosoma mansoni intermediate filament proteins 0.0029 0.0029 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0056 0.0121 0.0121
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0029 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0135 0.0187
Loa Loa (eye worm) hypothetical protein 0.0225 0.0698 0.1919
Onchocerca volvulus 0.0029 0.0029 0.0038
Mycobacterium tuberculosis Probable lipase LipE 0.0029 0.0029 0.0081
Chlamydia trachomatis DNA topoisomerase I 0.1087 0.3638 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0025 0.0015 0.0015
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0047 0.0091 0.0721
Schistosoma mansoni lamin 0.0029 0.0029 0.0029
Loa Loa (eye worm) glutathione reductase 0.0041 0.007 0.0193
Plasmodium vivax hypothetical protein, conserved 0.1087 0.3638 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0015 0.0021
Echinococcus granulosus lamin 0.0029 0.0029 0.0028
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.1047 0.3499 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0029 0.0029 0.0081
Onchocerca volvulus 0.017 0.0511 0.1368
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0387 0.125 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0015 0.0021
Echinococcus granulosus intermediate filament protein 0.0029 0.0029 0.0028
Giardia lamblia PHD finger protein 15 0.0094 0.0252 0.0348
Entamoeba histolytica hypothetical protein 0.0055 0.012 0.0165
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0015 0.004
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.2143 0.7235 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0025 0.0018 0.0049
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.012 0.012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0048 0.0048
Echinococcus granulosus lamin dm0 0.0029 0.0029 0.0028
Echinococcus granulosus JmjC domain containing protein 4 0.0047 0.0091 0.0091
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0031 0.0036 0.0097
Echinococcus multilocularis SWI:SNF matrix associated 0.1087 0.3638 0.3638
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0002 0.0002
Onchocerca volvulus 0.0387 0.125 0.3408
Loa Loa (eye worm) hypothetical protein 0.0031 0.0035 0.0096
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0025 0.0017 0.0046
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0029 0.0079

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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