Detailed information for compound 1228553

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 606.061 | Formula: C30H36ClNO10
  • H donors: 4 H acceptors: 7 LogP: 3.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)C1c2cc3c(c(c2C(C[C@@]1(O)CC)O[C@H]1OC(C)C(C(C1)N(C)C)O)O)C(=O)c1c(C3=O)cccc1O.Cl
  • InChi: 1S/C30H35NO10.ClH/c1-6-30(38)12-19(41-20-11-17(31(3)4)25(33)13(2)40-20)22-15(24(30)29(37)39-5)10-16-23(28(22)36)27(35)21-14(26(16)34)8-7-9-18(21)32;/h7-10,13,17,19-20,24-25,32-33,36,38H,6,11-12H2,1-5H3;1H/t13?,17?,19?,20-,24?,25?,30+;/m1./s1
  • InChiKey: KTSRCTOUNGGQEI-VKZSXHDKSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens hemoglobin, beta Starlite/ChEMBL No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] hemoglobin, beta 147 aa 122 aa 20.5 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0048 0.0165 0.1659
Schistosoma mansoni DNA polymerase eta 0.0037 0.0112 0.0112
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Echinococcus multilocularis Rho GTPase activating protein 24 0.0048 0.0165 0.0165
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0051 0.198
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0226 0.0507
Echinococcus multilocularis regulator of G protein signaling 3 0.0305 0.13 0.13
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0112 0.074
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0051 0.2567
Leishmania major DNA polymerase kappa, putative 0.0045 0.0147 0.6529
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0305 0.13 0.13
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0048 0.0165 0.037
Brugia malayi Oxysterol-binding protein 0.0048 0.0165 0.037
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0024 0.0337
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0586 0.0586
Schistosoma mansoni axis inhibition protein axin 0.0305 0.13 0.13
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0056 0.0197 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0148 0.0332
Echinococcus granulosus beta 1 syntrophin 0.0048 0.0165 0.0165
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0151 0.0151
Trypanosoma cruzi PH domain containing protein, putative 0.0048 0.0165 0.6469
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.000000000043743 0.000000000098203
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0208 0.0467
Echinococcus granulosus bloom syndrome protein 0.0024 0.0056 0.0056
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0148 0.5807
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Brugia malayi follicle stimulating hormone receptor 0.0231 0.0972 0.2183
Entamoeba histolytica hypothetical protein 0.0048 0.0165 0.1088
Echinococcus multilocularis rac serine:threonine kinase 0.0056 0.0197 0.0197
Echinococcus granulosus regulator of G protein signaling 7 0.0305 0.13 0.13
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0112 0.4398
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0121 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0048 0.0165 0.8353
Entamoeba histolytica ARF GTPase activating protein, putative 0.0048 0.0165 0.1088
Entamoeba histolytica hypothetical protein 0.0056 0.0197 0.1302
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0002 0.0075
Echinococcus granulosus pleckstrin y domain containing family A 0.0048 0.0165 0.0165
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0056 0.0197 0.7746
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0051 0.0334
Brugia malayi PXA domain containing protein 0.0305 0.13 0.2919
Toxoplasma gondii exonuclease III APE 0.0023 0.0051 0.1935
Echinococcus multilocularis ferritin 0.0017 0.0024 0.0024
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0305 0.13 0.13
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0134 0.0887
Entamoeba histolytica hypothetical protein 0.0305 0.13 0.8584
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0109 0.0717
Echinococcus multilocularis regulator of G protein signaling 3 0.0305 0.13 0.13
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0009 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0048 0.0165 0.0165
Toxoplasma gondii hypothetical protein 0.0048 0.0165 0.6296
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0056 0.0197 0.7746
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0109 0.0717
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0305 0.13 0.13
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0147 0.1784
Loa Loa (eye worm) hypothetical protein 0.0043 0.0143 0.0143
Schistosoma mansoni regulator of G protein signaling 0.0305 0.13 0.13
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0048 0.0165 0.6469
Brugia malayi TBC domain containing protein 0.0048 0.0165 0.037
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0048 0.0165 0.8353
Leishmania major serine/threonine-protein kinase a, putative 0.0056 0.0197 0.8735
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0002 0.0002
Onchocerca volvulus 0.0011 0.0000000054881 0.000000055268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0004 0.0004
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0004 0.0004
Echinococcus multilocularis myotubularin protein 13 0.0048 0.0165 0.0165
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0207 0.0207
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0056 0.037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.000000000043743 0.000000000043743
Echinococcus granulosus regulator of G protein signaling 3 0.0305 0.13 0.13
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0112 0.0252
Loa Loa (eye worm) hypothetical protein 0.0037 0.0112 0.0112
Brugia malayi hypothetical protein 0.0305 0.13 0.2919
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0095 0.1025
Plasmodium vivax DNA repair protein REV1, putative 0.0011 0 0.0014
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0109 0.0109
Brugia malayi Plekhf2 protein 0.0048 0.0165 0.037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0004 0.0004
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0048 0.0165 0.0165
Echinococcus granulosus chromobox protein 1 0.0069 0.0256 0.0256
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0281 0.0281
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0009 0.0009
Trypanosoma brucei DNA polymerase eta, putative 0.0037 0.0112 0.44
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0048 0.0165 0.0165
Loa Loa (eye worm) rho-GTPase-activating 0.0048 0.0165 0.0165
Loa Loa (eye worm) oxysterol binding protein 0.0048 0.0165 0.0165
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0226 0.0226
Brugia malayi Pleckstrin Homology Domain 0.0048 0.0165 0.037
Onchocerca volvulus 0.0012 0.0004 0.0041
Schistosoma mansoni goodpasture antigen-binding protein 0.0048 0.0165 0.0165
Entamoeba histolytica hypothetical protein 0.0011 0.000000000043743 0.00000000028885
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0151 0.0151
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0004 0.0009
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0256 0.0256
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0004 0.0004
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0148 0.0148
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0712 0.3104 0.3104
Brugia malayi SET domain containing protein 0.0013 0.0008 0.0018
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0309 0.0309
Schistosoma mansoni regulator of G protein signaling 0.0305 0.13 0.13
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Echinococcus multilocularis expressed protein 0.0305 0.13 0.13
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0151 0.0151
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1016 0.4454 0.4454
Plasmodium falciparum PH domain-containing protein, putative 0.0048 0.0165 0.8353
Echinococcus multilocularis Oxysterol binding protein 11 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0305 0.13 0.13
Plasmodium falciparum oxysterol-binding protein, putative 0.0048 0.0165 0.8353
Entamoeba histolytica hypothetical protein 0.0305 0.13 0.8584
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.0226 1
Echinococcus granulosus expressed protein 0.0305 0.13 0.13
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1216 0.1216
Entamoeba histolytica hypothetical protein 0.0056 0.0197 0.1302
Echinococcus granulosus oxysterol binding protein 3 0.0048 0.0165 0.0165
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0714 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0148 0.0148
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0009 0.006
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0305 0.13 0.13
Brugia malayi nuclear hormone receptor 0.0012 0.0004 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0071 0.0471
Schistosoma mansoni regulator of G protein signaling 0.0305 0.13 0.13
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3644 0.3644
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Loa Loa (eye worm) hypothetical protein 0.0305 0.13 0.13
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Echinococcus granulosus regulator of G protein signaling 7 0.0305 0.13 0.13
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0084 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0056 0.0197 0.1302
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0051 0.0051
Echinococcus multilocularis dynamin 1 0.0048 0.0165 0.0165
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0051 0.0385
Echinococcus multilocularis oxysterol binding protein 1 0.0048 0.0165 0.0165
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0051 0.2585
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.000000000043743 0.0000000022185
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.023
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0148 0.0148
Echinococcus granulosus chromobox protein 1 0.0069 0.0256 0.0256
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.006
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0109 0.0717
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0004 0.0004
Brugia malayi regulator of G-protein signaling egl-10 0.0305 0.13 0.2919
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Schistosoma mansoni apoferritin-2 0.0017 0.0024 0.0024
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0056 0.0197 0.7746
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0712 0.3104 0.3104
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0012 0.0002 0.01
Trypanosoma cruzi hypothetical protein 0.0048 0.0165 0.6469
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0197 0.1302
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0305 0.13 0.13
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0004 0.0009
Brugia malayi Regulator of G protein signaling domain containing protein 0.0305 0.13 0.2919
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0024 0.0337
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0134 0.1353
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0121 0.0801
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0076 0.0076
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.0226 0.0226
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0056 0.2193
Entamoeba histolytica protein kinase, putative 0.0056 0.0197 0.1302
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0112 0.4398
Loa Loa (eye worm) inositol-1 0.0037 0.0112 0.0112
Entamoeba histolytica PH domain containing protein 0.0048 0.0165 0.1088
Brugia malayi hypothetical protein 0.0286 0.1216 0.2729
Echinococcus multilocularis regulator of G protein signaling 7 0.0305 0.13 0.13
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0112 0.1566
Loa Loa (eye worm) uncoordinated protein 104 0.0048 0.0165 0.0165
Onchocerca volvulus 0.0048 0.0165 0.1659
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Brugia malayi Uncoordinated protein 104 0.0048 0.0165 0.037
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0714 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0056 0.0197 0.7746
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0016 0.0107
Entamoeba histolytica protein kinase, putative 0.0056 0.0197 0.1302
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0109 0.0109
Echinococcus multilocularis tumor protein p63 0.0408 0.1759 0.1759
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Echinococcus multilocularis Regulator of G protein signaling 20 0.0305 0.13 0.13
Trichomonas vaginalis DNA polymerase eta, putative 0.0069 0.0254 0.168
Onchocerca volvulus 0.006 0.0215 0.2162
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0095 0.1025
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0148 0.0148
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0148 0.0975
Echinococcus multilocularis expressed protein 0.0017 0.0024 0.0024
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0109 0.4807
Trichomonas vaginalis centaurin/arf, putative 0.0048 0.0165 0.1088
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.0972 0.0972
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Echinococcus granulosus dynamin 1 0.0048 0.0165 0.0165
Echinococcus granulosus Chromobox protein 3 0.0011 0.0000000054881 0.0000000054881
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0121 0.0802
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000043743 0.00000000028885
Echinococcus granulosus Chromo domain 0.0011 0.000000000043743 0.000000000043743
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.13 0.8584
Echinococcus multilocularis cytohesin 1 0.0048 0.0165 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0143 0.56
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3644 0.3644
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0056 0.0197 0.7746
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0165 0.1088
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0148 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0019 0.0123
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0109 0.0109
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0051 0.2993
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0084 0.0084
Leishmania major folate/biopterin transporter, putative 0.0056 0.0197 0.8735
Onchocerca volvulus Huntingtin homolog 0.0121 0.0488 0.4911
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0004 0.0004
Brugia malayi PXA domain containing protein 0.0305 0.13 0.2919
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0056 0.0197 0.7746
Brugia malayi Syntrophin-1 0.0048 0.0165 0.037
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0165 0.1088
Toxoplasma gondii protein kinase domain-containing protein 0.0056 0.0197 0.7538
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0048 0.0165 0.8353
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0048 0.0165 0.1088
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Brugia malayi CXXC zinc finger family protein 0.0035 0.0104 0.0233
Schistosoma mansoni hypothetical protein 0.0048 0.0165 0.0165
Echinococcus multilocularis regulator of G protein signaling 7 0.0305 0.13 0.13
Trypanosoma cruzi hypothetical protein 0.0048 0.0165 0.6469
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0004 0.0004
Schistosoma mansoni ap endonuclease 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0305 0.13 0.13
Schistosoma mansoni ferritin 0.0017 0.0024 0.0024
Echinococcus multilocularis Chromo domain 0.0011 0.000000000043743 0.000000000043743
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0048 0.0165 0.0165
Echinococcus multilocularis axis inhibition protein axin 0.0305 0.13 0.13
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0004 0.0009
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000043743 0.00000000028885
Brugia malayi Pre-SET motif family protein 0.003 0.0084 0.0189
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0004 0.0004
Echinococcus multilocularis GRB2 associated binding protein 3 0.0048 0.0165 0.0165
Brugia malayi Dynamin 0.0048 0.0165 0.037
Entamoeba histolytica p21-activated kinase 0.0056 0.0197 0.1302
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.023
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0309 0.0309
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0048 0.0165 0.037
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0048 0.0165 0.0165
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0056 0.2193
Brugia malayi Protein kinase domain containing protein 0.0056 0.0197 0.0443
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000043743 0.00000000028885
Leishmania major protein kinase, putative 0.0056 0.0197 0.8735
Onchocerca volvulus 0.0081 0.0309 0.3113
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0004 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0069 0.0254 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0004 0.0004
Echinococcus multilocularis beta 1 syntrophin 0.0048 0.0165 0.0165
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0051 0.2585
Entamoeba histolytica hypothetical protein 0.0305 0.13 0.8584
Trypanosoma cruzi hypothetical protein 0.0048 0.0165 0.6469
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0056 0.0197 0.7746
Schistosoma mansoni regulator of G protein signaling 0.0305 0.13 0.13
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0056 0.0056
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0004 0.0004
Trichomonas vaginalis centaurin/arf, putative 0.0048 0.0165 0.1088
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0048 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0071 0.0471
Schistosoma mansoni centaurin alpha 0.0048 0.0165 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0097 0.3809
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0004 0.0009
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0048 0.0165 0.8353
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0004 0.0009
Schistosoma mansoni serine/threonine-protein kinase 0.0056 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0305 0.13 0.13
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0069 0.0254 0.168
Onchocerca volvulus 0.0048 0.0165 0.1659
Brugia malayi nuclear receptor NHR-88 0.0012 0.0004 0.0009
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0226 0.3157
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0147 0.579
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0112 1
Loa Loa (eye worm) RGS-3 protein 0.0305 0.13 0.13
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Echinococcus multilocularis calcium dependent secretion activator 1 0.0048 0.0165 0.0165
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0004 0.0009
Schistosoma mansoni hypothetical protein 0.0011 0.000000000043743 0.000000000043743
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0712 0.3104 0.3104
Loa Loa (eye worm) hypothetical protein 0.0121 0.0488 0.0488
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.1514 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0051 0.071
Onchocerca volvulus 0.0048 0.0165 0.1659
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Mycobacterium ulcerans DNA polymerase IV 0.0069 0.0254 0.356
Trypanosoma cruzi NIMA-related kinase, putative 0.0056 0.0197 0.7746
Toxoplasma gondii Oxysterol-binding protein 0.0048 0.0165 0.6296
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0002 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0051 0.198
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0004 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0051 0.1994
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Echinococcus multilocularis G protein coupled receptor kinase 1 0.1963 0.865 0.865
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0134 0.0134
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.0112 0.0112
Echinococcus granulosus Oxysterol binding protein 11 0.0048 0.0165 0.0165
Echinococcus multilocularis regulator of G protein signaling 0.0305 0.13 0.13
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0056 0.2142
Trypanosoma brucei protein kinase, putative 0.0056 0.0197 0.7746
Schistosoma mansoni alpha-glucosidase 0.0139 0.0565 0.0565
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2139 0.2139
Echinococcus multilocularis pdz domain containing protein 0.0048 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0165 0.1088
Schistosoma mansoni goodpasture antigen-binding protein 0.0048 0.0165 0.0165
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.0112 0.0112
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0305 0.13 0.13
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Echinococcus granulosus pdz domain containing protein 0.0048 0.0165 0.0165
Brugia malayi Cytohesin 3 0.0048 0.0165 0.037
Plasmodium vivax PH domain containing protein 0.0048 0.0165 0.8353
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0051 0.3032
Echinococcus multilocularis chromobox protein 1 0.0069 0.0256 0.0256
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0048 0.0165 0.1659
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0004 0.0004
Brugia malayi steroid hormone receptor 0.0012 0.0004 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.023
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0056 0.0126
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0112 0.074
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0069 0.0254 1
Schistosoma mansoni z-protein (S1r protein) 0.0305 0.13 0.13
Loa Loa (eye worm) hypothetical protein 0.0011 0.000000000043743 0.000000000043743
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0137 0.0137
Schistosoma mansoni ferritin 0.0017 0.0024 0.0024
Entamoeba histolytica protein kinase, putative 0.0056 0.0197 0.1302
Echinococcus multilocularis Pleckstrin y 0.0048 0.0165 0.0165
Loa Loa (eye worm) Plekhf2 protein 0.0048 0.0165 0.0165
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.006
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0004 0.0009
Brugia malayi hypothetical protein 0.0121 0.0488 0.1095
Schistosoma mansoni DNA helicase recq5 0.0024 0.0056 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.006
Schistosoma mansoni dynamin 0.0048 0.0165 0.0165
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0197 0.1302
Leishmania major hypothetical protein, conserved 0.0048 0.0165 0.7295
Echinococcus granulosus myotubularin protein 13 0.0048 0.0165 0.0165
Trypanosoma cruzi hypothetical protein 0.0048 0.0165 0.6469
Brugia malayi chromobox protein homolog 3 0.0039 0.0121 0.0272
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0048 0.0165 0.037
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0009 0.006
Schistosoma mansoni survival motor neuron protein 0.0058 0.0208 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0712 0.3104 0.3104
Loa Loa (eye worm) hypothetical protein 0.0305 0.13 0.13
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0568 0.0568
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0009 0.0345
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0009 0.0345
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0004 0.0004
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0056 0.0197 0.7746
Echinococcus multilocularis Pleckstrin y 0.0048 0.0165 0.0165
Brugia malayi regulator of G-protein signaling rgs-7 0.0305 0.13 0.2919
Toxoplasma gondii hypothetical protein 0.0048 0.0165 0.6296
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0056 0.2142
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0004 0.0147
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0665 0.0665
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0048 0.0165 0.0165
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0165 0.037
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.13 0.8584
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0056 0.0368
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0137 0.0905
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0048 0.0165 0.0165
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0004 0.0004
Schistosoma mansoni dynamin 0.0048 0.0165 0.0165
Loa Loa (eye worm) cytohesin 3 0.0048 0.0165 0.0165
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0197 0.1302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0151 0.0151
Entamoeba histolytica protein kinase, putative 0.0056 0.0197 0.1302
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0097 0.3809
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0004 0.0004
Schistosoma mansoni zinc finger protein 0.0048 0.0165 0.0165
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0148 0.0977
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.006
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0148 0.0148
Plasmodium falciparum DNA repair protein REV1, putative 0.0011 0 0.0014
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.2267 1 1
Trypanosoma brucei unspecified product 0.0025 0.0062 0.242
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0048 0.0165 0.1088
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0009 0.0389
Giardia lamblia DINP protein human, muc B family 0.0045 0.0147 0.0972
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0009 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0084 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0048 0.0165 0.8353
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0867 0.0867
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0056 0.037
Echinococcus granulosus dna polymerase eta 0.0037 0.0112 0.0112
Entamoeba histolytica PH domain containing protein 0.0048 0.0165 0.1088
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1216 0.1216
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Echinococcus granulosus cytohesin 1 0.0048 0.0165 0.0165
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.1514 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0712 0.3104 0.6969
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0148 0.0977
Leishmania major hypothetical protein, conserved 0.0048 0.0165 0.7295
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0665 0.0665
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0109 0.0717
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0004 0.0004
Echinococcus granulosus oxysterol binding protein 9 0.0048 0.0165 0.0165
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0051 0.2233
Trichomonas vaginalis alpha chimerin, putative 0.0048 0.0165 0.1088
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0056 0.0197 0.7746
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0056 0.0056
Echinococcus multilocularis pleckstrin y domain containing family A 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0081 0.0309 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Entamoeba histolytica hypothetical protein 0.0023 0.0051 0.0337
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0056 0.0197 0.8735
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0134 0.0887
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0121 0.6159
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0004 0.0009
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0148 0.0977
Brugia malayi hypothetical protein 0.0305 0.13 0.2919
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0048 0.0165 0.0165
Schistosoma mansoni syntrophin 0.0048 0.0165 0.0165
Echinococcus multilocularis actin binding protein anillin 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Brugia malayi ecdysteroid receptor 0.0012 0.0004 0.0009
Onchocerca volvulus 0.0093 0.0364 0.3661
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0112 0.4959
Brugia malayi Regulator of G protein signaling domain containing protein 0.0305 0.13 0.2919
Brugia malayi Pre-SET motif family protein 0.0207 0.0867 0.1946
Schistosoma mansoni apoferritin-2 0.0017 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.13 0.8584
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0051 0.0705
Echinococcus granulosus axis inhibition protein axin 0.0305 0.13 0.13
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0097 0.3809
Onchocerca volvulus 0.0235 0.0993 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0011 0 0.0011
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0056 0.0197 0.1302
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0305 0.13 0.8584
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0197 0.1302
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0004 0.0027
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0051 0.0385
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0109 0.4263
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0051 0.0332
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0056 0.037
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0148 0.0148
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0309 0.0309
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0256 0.1689
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0112 0.4284
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2139 0.2139
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0051 0.0311
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0056 0.037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0002 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1514 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0004 0.0004
Echinococcus multilocularis oxysterol binding protein 3 0.0048 0.0165 0.0165
Entamoeba histolytica hypothetical protein 0.0048 0.0165 0.1088
Loa Loa (eye worm) hypothetical protein 0.0039 0.0121 0.0121
Trypanosoma brucei unspecified product 0.0025 0.0062 0.242
Plasmodium falciparum calcium-dependent protein kinase 7 0.0056 0.0197 1
Loa Loa (eye worm) RecQ helicase 0.0024 0.0056 0.0056
Onchocerca volvulus outspread protein homolog 0.0048 0.0165 0.1659
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0219 0.8611
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000043743 0.00000000028885
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0051 0.198
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0056 0.0197 0.8735
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0109 0.0717
Schistosoma mansoni serine/threonine protein kinase 0.2267 1 1
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0148 0.0148
Echinococcus multilocularis dna polymerase eta 0.0037 0.0112 0.0112
Echinococcus granulosus GRB2 associated binding protein 3 0.0048 0.0165 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.2267 1 1
Trichomonas vaginalis centaurin gamma, putative 0.0048 0.0165 0.1088
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0000000054881 0.0000000054881
Trypanosoma brucei DNA polymerase IV, putative 0.0069 0.0254 1
Schistosoma mansoni ferritin light chain 0.0017 0.0024 0.0024
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0056 0.0197 0.7746
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0056 0.0056
Echinococcus multilocularis DCC interacting protein 13 beta 0.0048 0.0165 0.0165
Echinococcus multilocularis Ras associated and pleckstrin y 0.0048 0.0165 0.0165
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0051 0.2567
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0051 0.1948
Schistosoma mansoni oxysterol-binding protein 1 0.0048 0.0165 0.0165
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0586 0.0586
Echinococcus granulosus DCC interacting protein 13 beta 0.0048 0.0165 0.0165
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Schistosoma mansoni chromobox protein 0.0069 0.0256 0.0256
Onchocerca volvulus 0.0042 0.0134 0.1353
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0048 0.0165 0.0165
Schistosoma mansoni axis inhibition protein axin 0.0305 0.13 0.13
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0009 0.0009
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0148 0.0148
Echinococcus granulosus Pleckstrin y 0.0048 0.0165 0.0165
Echinococcus granulosus cpg binding protein 0.0037 0.0112 0.0112
Entamoeba histolytica hypothetical protein 0.0048 0.0165 0.1088
Trypanosoma cruzi Protein kinase B 0.0056 0.0197 0.7746
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0004 0.0004
Schistosoma mansoni oxysterol-binding protein 1 0.0048 0.0165 0.0165
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0004 0.0154
Schistosoma mansoni hypothetical protein 0.0058 0.0208 0.0208
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0009 0.006
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0004 0.0004
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0226 0.0226
Echinococcus granulosus tumor protein p63 0.0408 0.1759 0.1759
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0137 0.0905
Echinococcus granulosus Pleckstrin y 0.0048 0.0165 0.0165
Trypanosoma cruzi PH domain containing protein, putative 0.0048 0.0165 0.6469
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0197 0.1302
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0665 0.0665
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0048 0.0165 0.0165
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0215 0.0215
Schistosoma mansoni coup transcription factor 0.0012 0.0004 0.0004
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0665 0.0665
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0048 0.0165 0.0165
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0148 0.5807
Trypanosoma cruzi NIMA-related kinase, putative 0.0056 0.0197 0.7746
Onchocerca volvulus 0.0048 0.0165 0.1659
Schistosoma mansoni growth factor receptor-bound protein 0.0048 0.0165 0.0165
Echinococcus granulosus serine/threonine protein kinase 0.0056 0.0197 0.0197
Trichomonas vaginalis hypothetical protein 0.0048 0.0165 0.1088
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Echinococcus multilocularis axis inhibition protein axin 0.0305 0.13 0.13
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0109 0.0244
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0035 0.023
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0197 0.1302
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0051 0.0309
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000043743 0.00000000028885
Brugia malayi A-kinase anchor protein 10, precursor 0.0305 0.13 0.2919
Brugia malayi Dynamin 0.0048 0.0165 0.037
Brugia malayi probable spectrin beta chain 0.0048 0.0165 0.037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Plasmodium vivax SET domain protein, putative 0.003 0.0084 0.4277
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0256 0.1689
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0121 0.1222
Toxoplasma gondii phosphatidylinositol transfer protein 0.0048 0.0165 0.6296
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0009 0.002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0104 0.0104
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0048 0.0165 0.1659
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0112 0.44
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trypanosoma brucei glucosidase, putative 0.0036 0.0109 0.4263
Echinococcus granulosus G protein coupled receptor kinase 1 0.1963 0.865 0.865
Echinococcus granulosus Pleckstrin y 0.0048 0.0165 0.0165
Entamoeba histolytica PH domain containing protein 0.0048 0.0165 0.1088
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0165 0.1088
Schistosoma mansoni alpha glucosidase 0.0036 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Brugia malayi Oxysterol binding protein 0.0048 0.0165 0.037
Loa Loa (eye worm) PXA domain-containing protein 0.0305 0.13 0.13
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0109 0.0717
Onchocerca volvulus 0.003 0.0084 0.0849
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0048 0.0165 0.1088
Schistosoma mansoni alpha-glucosidase 0.0139 0.0565 0.0565
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0165 0.037
Schistosoma mansoni regulator of G protein signaling 0.0305 0.13 0.13
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0004 0.0004
Mycobacterium ulcerans DNA polymerase IV 0.0069 0.0254 0.356
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0004 0.0009
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1016 0.4454 1
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0112 0.074
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0056 0.2842
Schistosoma mansoni ferritin 0.0017 0.0024 0.0024
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0009 0.006
Brugia malayi polk-prov protein 0.0043 0.0143 0.032
Schistosoma mansoni rho gtpase activating protein 0.0048 0.0165 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.1016 0.4454 0.4454
Schistosoma mansoni chromobox protein 0.0069 0.0256 0.0256
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0109 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0048 0.0165 0.1088
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0109 0.4153
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0056 0.0197 0.7746
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0036 0.1361
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Onchocerca volvulus 0.0058 0.0208 0.2096
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Entamoeba histolytica protein kinase, putative 0.0056 0.0197 0.1302
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.0226 0.2918
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0109 0.0717
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0056 0.0056
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0048 0.0165 0.8353
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0137 0.5238
Schistosoma mansoni hypothetical protein 0.0494 0.2139 0.2139
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0121 0.08
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0109 0.4263
Trypanosoma cruzi DNA polymerase kappa, putative 0.0069 0.0254 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0056 0.0197 0.7746
Schistosoma mansoni inositol monophosphatase 0.0037 0.0112 0.0112
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0084 0.3224
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0004 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0004 0.0041
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0048 0.0165 0.1088
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0048 0.0165 0.1088
Brugia malayi Inositol-1 0.0037 0.0112 0.0252
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0048 0.0165 0.0165
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0147 0.6529
Entamoeba histolytica protein kinase, putative 0.0056 0.0197 0.1302
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.006 0.0215 0.0215
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0051 0.0334
Brugia malayi CHD4 protein 0.0013 0.0009 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0121 0.0801
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0004 0.0004
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0051 0.0334
Entamoeba histolytica hypothetical protein 0.0048 0.0165 0.1088
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0051 0.0051
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0112 0.0112
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0048 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Schistosoma mansoni inositol monophosphatase 0.0037 0.0112 0.0112
Echinococcus multilocularis oxysterol binding protein 9 0.0048 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0048 0.0165 0.0165
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0051 0.0114
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000043743 0.00000000028885
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.0112 0.074
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0004 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0048 0.0165 0.0165
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Echinococcus multilocularis cpg binding protein 0.0037 0.0112 0.0112
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0165 0.8353
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0112 0.0252
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0009 0.0091
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0084 0.0084
Onchocerca volvulus Putative zinc finger protein 0.0048 0.0165 0.1659
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0112 0.1272
Trichomonas vaginalis set domain proteins, putative 0.0235 0.0993 0.6557
Trichomonas vaginalis centaurin alpha, putative 0.0048 0.0165 0.1088
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0048 0.0165 0.6469
Schistosoma mansoni vav2 0.0048 0.0165 0.0165
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0011 0 0.0011
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0048 0.0165 0.0165
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0004 0.0204
Trichomonas vaginalis centaurin beta, putative 0.0048 0.0165 0.1088
Trypanosoma cruzi PH domain containing protein, putative 0.0048 0.0165 0.6469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Echinococcus granulosus oxysterol binding protein 1 0.0048 0.0165 0.0165
Echinococcus granulosus axis inhibition protein axin 0.0305 0.13 0.13
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.13 0.8584
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0148 0.0977
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0048 0.0165 0.0165
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0151 0.0151
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0004 0.0041
Schistosoma mansoni serine/threonine-protein kinase 0.0056 0.0197 0.0197
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0004 0.0004
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0048 0.0165 0.0165
Echinococcus multilocularis chromobox protein 1 0.0069 0.0256 0.0256
Onchocerca volvulus Huntingtin homolog 0.0121 0.0488 0.4911
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0056 0.0126
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0051 0.2248
Schistosoma mansoni hypothetical protein 0.0048 0.0165 0.0165
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0056 0.0126
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0665 0.1493
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Schistosoma mansoni zinc finger protein 0.0048 0.0165 0.0165
Onchocerca volvulus Protein melted homolog 0.0048 0.0165 0.1659
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0024 0.0135
Schistosoma mansoni cpg binding protein 0.0037 0.0112 0.0112
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0112 0.074
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0009
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0226 0.3157
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0084 0.0084
Brugia malayi hypothetical protein 0.0048 0.0165 0.037
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0056 0.2473
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0109 0.0717
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0254 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trypanosoma brucei rac serine-threonine kinase, putative 0.0056 0.0197 0.7746
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0137 0.695
Schistosoma mansoni cpg binding protein 0.0035 0.0104 0.0104
Onchocerca volvulus 0.0048 0.0165 0.1659
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0004 0.0004
Echinococcus multilocularis beta adrenergic receptor kinase 0.2267 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0004 0.0004
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0004 0.0004
Schistosoma mansoni ferritin light chain 0.0017 0.0024 0.0024
Trypanosoma cruzi PH domain containing protein, putative 0.0048 0.0165 0.6469
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0004 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.13 0.8584
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Loa Loa (eye worm) hypothetical protein 0.0286 0.1216 0.1216
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.0112 0.0112
Echinococcus multilocularis Pleckstrin y 0.0048 0.0165 0.0165
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0714 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0004 0.0004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0004 0.0004
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0056 0.2842
Echinococcus granulosus regulator of G protein signaling 3 0.0305 0.13 0.13
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3644 0.3644
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0048 0.0165 0.6469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0309 0.0694
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Trichomonas vaginalis ferritin, putative 0.0017 0.0024 0.0161
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0305 0.13 0.13
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.0112 0.0112
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0004 0.0004
Onchocerca volvulus 0.0035 0.0104 0.1044
Loa Loa (eye worm) acetyltransferase 0.0144 0.0586 0.0586
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1514 1
Trichomonas vaginalis protein transport protein sec7, putative 0.0048 0.0165 0.1088
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0004 0.0009
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0048 0.0165 0.1088
Leishmania major protein kinase, putative 0.0056 0.0197 0.8735
Echinococcus granulosus ferritin 0.0017 0.0024 0.0024
Brugia malayi PH domain containing protein 0.0048 0.0165 0.037
Trypanosoma brucei DNA polymerase IV, putative 0.0069 0.0254 1
Brugia malayi MAX-1A 0.0048 0.0165 0.037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0151 0.0151
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0165 0.1088
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0137 0.5238
Schistosoma mansoni cpg binding protein 0.0037 0.0112 0.0112
Toxoplasma gondii AtPH1 family protein 0.0048 0.0165 0.6296
Plasmodium vivax hypothetical protein, conserved 0.0011 0.000000000043743 0.0000000022185
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Trichomonas vaginalis kinesin light chain, putative 0.0048 0.0165 0.1088
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0112 0.4398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0004 0.0004
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0051 0.1948
Echinococcus granulosus Regulator of G protein signaling 20 0.0305 0.13 0.13
Trypanosoma brucei unspecified product 0.0061 0.0219 0.8611
Trypanosoma cruzi DNA polymerase kappa, putative 0.0069 0.0254 1
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0165 0.1088
Echinococcus multilocularis dna polymerase kappa 0.0069 0.0254 0.0254
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0143 0.56
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.000000000043743 0.0000000016722
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0048 0.0165 0.0165
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0048 0.0165 0.0165
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0009 0.006
Echinococcus granulosus calcium dependent secretion activator 1 0.0048 0.0165 0.0165
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0056 0.0197 0.7746
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0151 0.0151
Onchocerca volvulus 0.0048 0.0165 0.1659
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Entamoeba histolytica protein kinase, putative 0.0056 0.0197 0.1302
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0035 0.023
Trypanosoma cruzi hypothetical protein 0.0048 0.0165 0.6469
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0048 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0004 0.0004
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0051 0.5
Echinococcus granulosus dna polymerase kappa 0.0069 0.0254 0.0254
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0019 0.0123
Trypanosoma cruzi hypothetical protein 0.0048 0.0165 0.6469
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.0262 1
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.000000000043743 0.000000000043743
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0586 0.1316
Schistosoma mansoni ap endonuclease 0.0023 0.0051 0.0051
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.000000000043743 0.000000000098203
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.023
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0112 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0004 0.0009
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0004 0.0004
Loa Loa (eye worm) AGC/AKT protein kinase 0.0056 0.0197 0.0197
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0048 0.0165 0.0165
Echinococcus granulosus Rho GTPase activating protein 24 0.0048 0.0165 0.0165
Schistosoma mansoni DNA helicase recq1 0.0024 0.0056 0.0056
Loa Loa (eye worm) PH domain-containing protein 0.0048 0.0165 0.0165
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0004 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.13 0.8584
Schistosoma mansoni hypothetical protein 0.0048 0.0165 0.0165
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0051 0.071
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0009 0.0345
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0056 0.0197 0.7538
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0165 0.1088
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0048 0.0165 0.0165
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0056 0.0056
Echinococcus granulosus expressed protein 0.0017 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0004 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Brugia malayi Cadps2 protein 0.0048 0.0165 0.037
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0197 0.1302
Loa Loa (eye worm) syntrophin-1 0.0048 0.0165 0.0165
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.0112 0.0112
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0151 0.0338
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0148 0.5807
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0109 0.0717
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0002 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1514 1
Trypanosoma brucei PH domain containing protein, putative 0.0048 0.0165 0.6469
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0051 0.038
Schistosoma mansoni ferritin 0.0017 0.0024 0.0024
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0148 0.6549
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0165 0.1088
Schistosoma mansoni myotubularin-related protein 0.0048 0.0165 0.0165
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0109 0.0717
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0004 0.0004
Brugia malayi Heterochromatin protein 1 0.0069 0.0256 0.0574
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0084 0.0084
Trypanosoma cruzi hypothetical protein 0.0048 0.0165 0.6469
Trichomonas vaginalis protein transport protein sec7, putative 0.0048 0.0165 0.1088
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.000000000043743 0.000000000043743
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Leishmania major DNA polymerase eta, putative 0.0037 0.0112 0.4962

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (binding) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) = 11.1936 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: Confirmation and Secondary Assay for Modulators of Hemoglobin Beta Chain Splicing at IVS2 654 locus. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: Confirmation and Secondary Assay for Modulators of Hemoglobin Beta Chain Splicing at IVS2 705 locus. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (ADMET) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2549 (qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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