Detailed information for compound 1274499

Basic information

Technical information
  • TDR Targets ID: 1274499
  • Name: ethyl 4-(4-fluorophenyl)imidazo[1,2-a]quinoxa line-7-carboxylate
  • MW: 335.332 | Formula: C19H14FN3O2
  • H donors: 0 H acceptors: 3 LogP: 4.1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc2c(c1)nc(c1n2ccn1)c1ccc(cc1)F
  • InChi: 1S/C19H14FN3O2/c1-2-25-19(24)13-5-8-16-15(11-13)22-17(18-21-9-10-23(16)18)12-3-6-14(20)7-4-12/h3-11H,2H2,1H3
  • InChiKey: UYMZHMLAYWPWIC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-fluorophenyl)-7-imidazo[1,2-a]quinoxalinecarboxylic acid ethyl ester
  • 4-(4-fluorophenyl)imidazo[1,2-a]quinoxaline-7-carboxylic acid ethyl ester
  • MLS000391608
  • SMR000260643
  • T0509-4249

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0035 0.0136
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0035 0.0136
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0035 0.0033
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.0113 0.0111
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0068 0.0126 0.052
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Brugia malayi jmjC domain containing protein 0.0071 0.0134 0.06
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0123 0.0257 0.4957
Schistosoma mansoni single-minded 0.0052 0.0089 0.0087
Brugia malayi jmjC domain containing protein 0.0071 0.0134 0.06
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.003 0.0037 0.0035
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0134 0.0132
Brugia malayi RNA, U transporter 1 0.0086 0.0168 0.0756
Echinococcus multilocularis neuropeptide s receptor 0.1535 0.3603 0.3602
Trichomonas vaginalis ran, putative 0.0022 0.0018 0.0067
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0044 0.0191
Onchocerca volvulus 0.0697 0.1616 0.6769
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.0257 0.0255
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Echinococcus granulosus rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0139 0.0137
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0011
Trypanosoma brucei unspecified product 0.004 0.0059 0.0794
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0037 0.048
Loa Loa (eye worm) fatty acid synthase 0.0038 0.0056 0.0246
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0041 0.0063 0.1935
Schistosoma mansoni loxhd1 0.0022 0.0017 0.0016
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0134 0.0132
Onchocerca volvulus 0.0036 0.0052 0.0206
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0044 0.0042
Echinococcus multilocularis neuropeptides capa receptor 0.0697 0.1616 0.1614
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0151
Schistosoma mansoni nuclear receptor 0.0029 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0038
Echinococcus multilocularis dna polymerase eta 0.004 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Brugia malayi hypothetical protein 0.0029 0.0035 0.0151
Onchocerca volvulus 0.0697 0.1616 0.6769
Echinococcus granulosus lamin 0.0059 0.0106 0.0104
Echinococcus granulosus sex peptide receptor 0.0697 0.1616 0.1614
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0035 0.0033
Schistosoma mansoni biogenic amine (5HT) receptor 0.0697 0.1616 0.1614
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.0031 0.0669
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0059 0.1763
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.0794
Brugia malayi hypothetical protein 0.0029 0.0035 0.0151
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0197 0.0432 0.5944
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0105 0.0434
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0158
Echinococcus granulosus allatostatin A receptor 0.0697 0.1616 0.1614
Schistosoma mansoni tar DNA-binding protein 0.0065 0.012 0.0118
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0049 0.0047
Brugia malayi hypothetical protein 0.0697 0.1616 0.734
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0044 0.0042
Schistosoma mansoni hypothetical protein 0.0697 0.1616 0.1614
Schistosoma mansoni phd/f-box containing protein 0.0019 0.001 0.0008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0129 0.027 0.6238
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0697 0.1616 0.1614
Brugia malayi beta-lactamase family protein 0.0036 0.0052 0.0226
Loa Loa (eye worm) MH2 domain-containing protein 0.0515 0.1186 0.5384
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0153 0.0329 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.0389
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0019 0.0011 0.021
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0089 0.0177 0.0733
Onchocerca volvulus 0.0697 0.1616 0.6769
Echinococcus granulosus rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.003 0.0037 0.0504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.0435 0.0433
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0019 0.046
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.0257 0.3512
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0019 0.046
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0039 0.0057 0.0251
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0025 0.0025 0.0535
Echinococcus multilocularis flap endonuclease 1 0.0019 0.0011 0.0009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0052 0.0968
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.0794
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0019 0.0327
Onchocerca volvulus 0.0029 0.0035 0.0136
Onchocerca volvulus 0.0697 0.1616 0.6769
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0697 0.1616 0.734
Brugia malayi beta-lactamase 0.0036 0.0052 0.0226
Echinococcus granulosus single minded 2 0.0039 0.0057 0.0055
Brugia malayi 6-phosphofructokinase 0.0123 0.0257 0.1159
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0089 0.0177 0.0733
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0019 0.046
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0123 0.0257 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0697 0.1616 0.1614
Trichomonas vaginalis flap endonuclease-1, putative 0.0019 0.0011 0.0038
Loa Loa (eye worm) hypoxia-induced factor 1 0.0162 0.0348 0.1576
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0165 0.0684
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0019 0.039
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0044 0.2592
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0113 0.0111
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0697 0.1616 0.1614
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0016 0.0395
Echinococcus granulosus Ankyrin 0.0016 0.0004 0.0002
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0052 0.0968
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0139 0.0137
Onchocerca volvulus 0.0081 0.0157 0.0648
Echinococcus granulosus tar DNA binding protein 0.0065 0.012 0.0118
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0041 0.0063 0.1669
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0019 0.046
Loa Loa (eye worm) hypothetical protein 0.0036 0.0052 0.0226
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0059 0.0242
Brugia malayi RNA binding protein 0.0065 0.012 0.0536
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0697 0.1616 0.734
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0061 0.0111 0.0109
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0106 0.0475
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0139 0.1913
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.003 0.0037 0.0504
Echinococcus multilocularis snurportin 1 0.0321 0.0726 0.0724
Echinococcus granulosus intermediate filament protein 0.0059 0.0106 0.0104
Schistosoma mansoni hypothetical protein 0.0321 0.0726 0.0724
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.001 0.0008
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Echinococcus granulosus rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Brugia malayi neuropeptide F receptor 0.0697 0.1616 0.734
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0257 0.1069
Echinococcus granulosus histone lysine methyltransferase setb 0.0129 0.027 0.0269
Loa Loa (eye worm) hypothetical protein 0.0081 0.0157 0.0706
Echinococcus granulosus survival motor neuron protein 1 0.0267 0.0599 0.0597
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0023 0.0322
Loa Loa (eye worm) hypothetical protein 0.0025 0.0023 0.0098
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0198 0.0435 0.0433
Echinococcus granulosus FTZ F1 alpha 0.0062 0.0113 0.0111
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0044 0.0177
Echinococcus multilocularis RUN 0.0022 0.0017 0.0016
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0052 0.005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0037 0.0504
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.003 0.0392
Echinococcus multilocularis thyroid hormone receptor alpha 0.0062 0.0113 0.0111
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0035 0.0033
Echinococcus multilocularis G protein coupled receptor 139 0.0697 0.1616 0.1614
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0044 0.0982
Brugia malayi hypothetical protein 0.0022 0.0017 0.0071
Schistosoma mansoni transcription factor btf3 0.0084 0.0165 0.0163
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.003 0.0037 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0019 0.0327
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0019 0.0327
Brugia malayi nuclear receptor RXR 0.0029 0.0035 0.0151
Echinococcus granulosus rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0019 0.046
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0165 0.0357 0.1488
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0089 0.0177 0.2427
Mycobacterium tuberculosis Conserved protein 0.0036 0.0052 0.0968
Loa Loa (eye worm) hypothetical protein 0.0062 0.0113 0.0505
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0089 0.0177 0.0733
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0091 0.0404
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0032 0.0042 0.1062
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0697 0.1616 0.734
Brugia malayi hypothetical protein 0.0697 0.1616 0.734
Brugia malayi N-terminal motif family protein 0.0165 0.0357 0.1616
Loa Loa (eye worm) hypothetical protein 0.0084 0.0165 0.0744
Echinococcus multilocularis g protein coupled receptor 0.0697 0.1616 0.1614
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0165 0.0684
Onchocerca volvulus 0.0029 0.0035 0.0136
Echinococcus granulosus dro:myosuppressin receptor 0.0697 0.1616 0.1614
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0052 0.0209
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0697 0.1616 0.1614
Schistosoma mansoni protein phosphatase 2C 0.0019 0.001 0.0008
Mycobacterium ulcerans lipase LipD 0.0036 0.0052 0.1363
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0134 0.06
Brugia malayi Smad1 0.0035 0.0049 0.0212
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0037 0.0504
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.0257 0.0255
Onchocerca volvulus 0.0022 0.0017 0.0062
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0059 0.0794
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.0257 0.1159
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.003 0.0037 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Schistosoma mansoni smad1 5 8 and 0.0035 0.0049 0.0047
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.003 0.0037 0.0809
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.0113 0.0111
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0697 0.1616 0.1614
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0052 0.0087 0.0389
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0044 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0113 0.0505
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0134 0.0132
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.0727 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0071
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0059 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.027 0.0269
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0153 0.0329 0.0327
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0041 0.0178
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.0113 0.0111
Schistosoma mansoni smad 0.0035 0.0049 0.0047
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0019 0.0327
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0031 0.0039 0.1023
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.0257 0.78
Brugia malayi Melatonin receptor type 1A 0.0697 0.1616 0.734
Brugia malayi hypothetical protein 0.0697 0.1616 0.734
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0059 0.0058
Onchocerca volvulus Neuropeptide F receptor homolog 0.0697 0.1616 0.6769
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0018 0.0684
Brugia malayi ORL1-like opioid receptor 0.0697 0.1616 0.734
Echinococcus granulosus neuropeptide receptor 0.0697 0.1616 0.1614
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0153 0.0329 0.0327
Leishmania major ATP-dependent phosphofructokinase 0.0123 0.0257 0.3528
Echinococcus granulosus X box binding protein 1 0.029 0.0652 0.065
Leishmania major cytochrome p450-like protein 0.0022 0.0019 0.0256
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0113 0.0505
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0019 0.0256
Echinococcus granulosus g-protein coupled receptor 0.0697 0.1616 0.1614
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0002 0.0025
Brugia malayi Serotonin receptor 0.0697 0.1616 0.734
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.0257 0.3528
Schistosoma mansoni biogenic amine receptor 0.0697 0.1616 0.1614
Entamoeba histolytica hypothetical protein 0.0113 0.0233 0.7064
Echinococcus multilocularis geminin 0.0413 0.0945 0.0943
Plasmodium vivax flap endonuclease 1, putative 0.0019 0.0011 0.021
Brugia malayi Flap endonuclease-1 0.0019 0.0011 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.027 0.0269
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Echinococcus multilocularis g protein coupled receptor 0.0697 0.1616 0.1614
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.0233 0.0231
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0052 0.0087 0.0359
Loa Loa (eye worm) hypothetical protein 0.0267 0.0599 0.2715
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0091 0.0089
Echinococcus granulosus GPCR family 2 0.0053 0.0091 0.0089
Schistosoma mansoni Smad4 0.0035 0.0049 0.0047
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.0113 0.0111
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0044 0.1294
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0023 0.009
Schistosoma mansoni biogenic amine (5HT) receptor 0.0697 0.1616 0.1614
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0697 0.1616 0.1614
Trichomonas vaginalis set domain proteins, putative 0.1021 0.2386 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0044 0.0982
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0026 0.0026 0.0407
Leishmania major cytochrome p450-like protein 0.0022 0.0019 0.0256
Brugia malayi hypothetical protein 0.0697 0.1616 0.734
Echinococcus granulosus g protein coupled receptor 0.0697 0.1616 0.1614
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0257 0.1069
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0019 0.0011 0.0149
Echinococcus granulosus tm gpcr rhodopsin 0.0697 0.1616 0.1614
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0113 0.0111
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0041 0.0063 0.1185
Echinococcus granulosus histone acetyltransferase KAT2B 0.0286 0.0643 0.0641
Echinococcus multilocularis rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Loa Loa (eye worm) hypothetical protein 0.0036 0.0052 0.0226
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0023 0.0319
Loa Loa (eye worm) acetyltransferase 0.0294 0.0663 0.3005
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.001 0.0008
Entamoeba histolytica Ran family GTPase 0.0022 0.0018 0.0491
Loa Loa (eye worm) neuropeptide F receptor 0.0697 0.1616 0.734
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0126 0.1728
Brugia malayi MH1 domain containing protein 0.0019 0.0011 0.0044
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Echinococcus multilocularis transcription factor Dp 1 0.0089 0.0176 0.0174
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0198 0.0435 0.1969
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.003 0.0037 0.0035
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0041 0.0063 0.1669
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0019 0.046
Plasmodium vivax JmjC domain containing protein 0.0019 0.001 0.0197
Mycobacterium ulcerans hypothetical protein 0.0036 0.0052 0.1363
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0033 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.0794
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.001 0.0038
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0037 0.0809
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0049 0.0047
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0044 0.0177
Echinococcus multilocularis neuropeptides capa receptor 0.0697 0.1616 0.1614
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0006 0.0018
Mycobacterium leprae Polyketide synthase Pks13 0.0058 0.0102 0.3583
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0197 0.0432 1
Schistosoma mansoni Smad4 0.0016 0.0003 0.0001
Onchocerca volvulus 0.1022 0.2386 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0052 0.0968
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0697 0.1616 0.1614
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0035 0.0033
Echinococcus granulosus dna polymerase kappa 0.004 0.0059 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0037 0.0504
Brugia malayi hypothetical protein 0.0697 0.1616 0.734
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0044 0.0982
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0113 0.0505
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0006 0.0018
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0035 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.0113 0.0505
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.001 0.0008
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0697 0.1616 0.1614
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0697 0.1616 0.734
Brugia malayi tailless protein 0.0029 0.0035 0.0151
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0257 0.1069
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0059 0.0058
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.0257 0.78
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0036 0.0051 0.0224
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0044
Onchocerca volvulus 0.0697 0.1616 0.6769
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0044 0.0042
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0052 0.1363
Leishmania major mitochondrial DNA polymerase beta 0.0322 0.0727 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.003 0.0037 0.0146
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0019 0.046
Brugia malayi hypothetical protein 0.0697 0.1616 0.734
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.0817
Plasmodium falciparum cGMP-specific phosphodiesterase 0.003 0.0037 0.2135
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0018 0.0221
Schistosoma mansoni histamine h1 receptor 0.0697 0.1616 0.1614
Trypanosoma brucei protein kinase, putative 0.0114 0.0236 0.323
Loa Loa (eye worm) hypothetical protein 0.0059 0.0106 0.0475
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0114 0.0236 0.323
Echinococcus granulosus adenylate cyclase type IX 0.0119 0.0247 0.0245
Loa Loa (eye worm) hypothetical protein 0.0129 0.027 0.1221
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0019 0.0327
Schistosoma mansoni lipoxygenase 0.0061 0.0111 0.0109
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Mycobacterium ulcerans beta-lactamase 0.0036 0.0052 0.1363
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0059 0.112
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Mycobacterium ulcerans thioesterase 0.0032 0.0042 0.1095
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0023 0.1328
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0043 0.0189
Echinococcus granulosus neuropeptide Y receptor 0.0697 0.1616 0.1614
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0153 0.0329 0.4516
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0039 0.0057 0.1074
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0023 0.009
Loa Loa (eye worm) G-protein coupled receptor 0.0697 0.1616 0.734
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0019 0.046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0113 0.0111
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0153 0.0329 0.4516
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.0113 0.0111
Echinococcus granulosus serotonin receptor 0.0697 0.1616 0.1614
Echinococcus granulosus mitogen activated protein kinase 0.0114 0.0236 0.0234
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0037 0.048
Brugia malayi sulfakinin receptor protein 0.0697 0.1616 0.734
Trypanosoma brucei transcription factor BTF3, putative 0.0084 0.0165 0.2247
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0004 0.001
Mycobacterium ulcerans polyketide synthase 0.0039 0.0057 0.1513
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Echinococcus granulosus dna polymerase eta 0.004 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Plasmodium vivax phosphodiesterase gamma, putative 0.003 0.0037 0.0809
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0019 0.0327
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Echinococcus multilocularis fmrfamide receptor 0.0697 0.1616 0.1614
Echinococcus multilocularis neuropeptide Y receptor 0.0697 0.1616 0.1614
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.0113 0.0111
Echinococcus multilocularis survival motor neuron protein 1 0.0267 0.0599 0.0597
Leishmania major cytochrome p450-like protein 0.0022 0.0019 0.0256
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0023 0.0503
Onchocerca volvulus 0.0039 0.0057 0.0228
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0139 0.3189
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Echinococcus multilocularis mothers against decapentaplegic 2 0.0016 0.0003 0.0001
Onchocerca volvulus 0.0697 0.1616 0.6769
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.0326 0.4468
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Brugia malayi latrophilin 2 splice variant baaae 0.0114 0.0236 0.1064
Schistosoma mansoni hypothetical protein 0.0113 0.0233 0.0231
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.003 0.0037 0.0035
Echinococcus granulosus biogenic amine 5HT receptor 0.0697 0.1616 0.1614
Brugia malayi Dopamine receptor protein 2 0.0697 0.1616 0.734
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0089 0.0087
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0017 0.0016
Schistosoma mansoni netrin receptor unc5 0.0016 0.0004 0.0002
Toxoplasma gondii type I fatty acid synthase, putative 0.0041 0.0063 0.1415
Schistosoma mansoni hypothetical protein 0.0413 0.0945 0.0943
Mycobacterium ulcerans polyketide synthase Pks13 0.0058 0.0102 0.2755
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0114 0.0236 0.3247
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0697 0.1616 0.1614
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0044 0.0177
Loa Loa (eye worm) nuclear factor I 0.0019 0.0011 0.0044
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.0113 0.0505
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0018 0.0983
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0697 0.1616 0.1614
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0017 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.0817
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0114 0.0236 0.5444
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0019 0.0327
Echinococcus granulosus mothers against decapentaplegic 2 0.0016 0.0003 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.0435 0.0433
Toxoplasma gondii NAC domain-containing protein 0.0084 0.0165 0.3787
Echinococcus multilocularis X box binding protein 1 0.029 0.0652 0.065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0049 0.0047
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0044 0.1803
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0004 0.0002
Brugia malayi AKH receptor 0.0697 0.1616 0.734
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Schistosoma mansoni importin beta-1 0.003 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.003 0.0037 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.0113 0.0505
Brugia malayi MH2 domain containing protein 0.0035 0.0049 0.0212
Schistosoma mansoni hypothetical protein 0.0053 0.0091 0.0089
Echinococcus multilocularis neuropeptide receptor 0.0697 0.1616 0.1614
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0562 0.1296 0.1294
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0018 0.0016
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0037 0.0035
Onchocerca volvulus 0.0697 0.1616 0.6769
Leishmania major DNA polymerase kappa, putative 0.004 0.0059 0.0817
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0151
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0058 0.0102 0.1956
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0044 0.0974
Schistosoma mansoni biogenic amine receptor 0.0697 0.1616 0.1614
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0043 0.0042
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0035 0.0033
Schistosoma mansoni cytochrome P450 0.0022 0.0019 0.0017
Loa Loa (eye worm) transcription factor SMAD2 0.0515 0.1186 0.5384
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0037 0.0146
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0037 0.0054 0.102
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0044 0.0982
Echinococcus multilocularis serotonin receptor 0.0697 0.1616 0.1614
Onchocerca volvulus 0.0062 0.0113 0.0463
Echinococcus granulosus 7TM GPCR rhodopsin 0.0697 0.1616 0.1614
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0037 0.0035
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0017 0.0006 0.0018
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0697 0.1616 0.1614
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.0113 0.0111
Brugia malayi nuclear receptor RXR 0.0033 0.0043 0.0189
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0019 0.046
Schistosoma mansoni polycystin 1-related 0.0022 0.0017 0.0016
Plasmodium falciparum phosphodiesterase delta, putative 0.003 0.0037 0.2135
Onchocerca volvulus 0.0697 0.1616 0.6769
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0035 0.0151
Schistosoma mansoni hypothetical protein 0.0022 0.0019 0.0017
Brugia malayi G-protein coupled receptor 0.0697 0.1616 0.734
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.003 0.0037 0.0146
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.0113 0.0505
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0052 0.0968
Brugia malayi Tachykinin-like peptides receptor 99D 0.0697 0.1616 0.734
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0035 0.0033
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0036 0.0051 0.0957
Brugia malayi nuclear hormone receptor 0.0062 0.0113 0.0505
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0198 0.0435 0.0433
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.0794
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.0113 0.0111
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0153 0.0329 0.1486
Onchocerca volvulus 0.0697 0.1616 0.6769
Brugia malayi hypothetical protein 0.0025 0.0023 0.0098
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0197 0.0432 0.5944
Loa Loa (eye worm) beta-lactamase 0.0036 0.0052 0.0226
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0023 0.1328
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.0794
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0198 0.0435 0.1969
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0019 0.0327
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0089 0.0177 0.0175
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0139 0.3763
Echinococcus granulosus mitogen activated protein kinase 3 0.0114 0.0236 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0177 0.0733
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0153 0.0329 0.4516
Echinococcus granulosus tm gpcr rhodopsin 0.0697 0.1616 0.1614
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0059 0.0262
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0151
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0043 0.0189
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0089 0.0177 0.0733
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.002 0.0012 0.023
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0037 0.0809
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0322 0.0727 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0052 0.0226
Plasmodium falciparum flap endonuclease 1 0.0019 0.0011 0.0554
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0059 0.0794
Onchocerca volvulus 0.0022 0.0017 0.0062
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0052 0.0968
Brugia malayi hypoxia-induced factor 1 0.0162 0.0348 0.1576
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0019 0.046
Brugia malayi mothers against decapentaplegic homolog 3 0.0016 0.0003 0.0003
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0139 0.0137
Mycobacterium ulcerans Type I modular polyketide synthase 0.0039 0.0057 0.1513
Entamoeba histolytica hypothetical protein 0.0024 0.0023 0.0654
Onchocerca volvulus 0.0084 0.0165 0.0684
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Brugia malayi Steroid receptor seven-up type 2 0.0155 0.0332 0.1501
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.001 0.0141
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0017 0.0006 0.0018
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0019 0.046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0697 0.1616 0.1614
Echinococcus multilocularis allatostatin A receptor 0.0697 0.1616 0.1614
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0019 0.046
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.0794
Mycobacterium tuberculosis Probable thioesterase TesA 0.0032 0.0042 0.0777
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0044 0.0177
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0697 0.1616 0.1614
Brugia malayi Adenylyl cyclase protein 0.0084 0.0165 0.0744
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.0113 0.0505
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0139 0.2671
Brugia malayi nuclear hormone receptor 0.0029 0.0035 0.0151
Brugia malayi steroid hormone receptor 0.0062 0.0113 0.0505
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0697 0.1616 0.1614
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0106 0.0475
Mycobacterium ulcerans Type I modular polyketide synthase 0.0039 0.0057 0.1513
Loa Loa (eye worm) hypothetical protein 0.0359 0.0815 0.37
Giardia lamblia Flap structure-specific endonuclease 0.0019 0.0011 0.0385
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0019 0.0327
Brugia malayi MH2 domain containing protein 0.0515 0.1186 0.5384
Brugia malayi neuropeptide F receptor 0.0697 0.1616 0.734
Echinococcus granulosus importin subunit beta 1 0.003 0.0037 0.0035
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0151
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0059 0.0058
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0006 0.0018
Brugia malayi jmjC domain containing protein 0.0019 0.001 0.0038
Loa Loa (eye worm) hypothetical protein 0.0033 0.0043 0.0189
Schistosoma mansoni lamin 0.0059 0.0106 0.0104
Echinococcus granulosus hypothetical protein 0.0697 0.1616 0.1614
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0017 0.0953
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0697 0.1616 0.1614
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0041 0.0063 0.1185
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0697 0.1616 0.1614
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0073 0.0997
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0073 0.0997
Echinococcus granulosus transcription factor Dp 1 0.0089 0.0176 0.0174
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.001 0.0038
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0068 0.0126 0.052
Echinococcus granulosus neuropeptides capa receptor 0.0697 0.1616 0.1614
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0035 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.0794
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0019 0.0011 0.0149
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0061 0.0111 0.0109
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0052 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0151
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0044 0.0177
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0041 0.0063 0.1935
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.001 0.0197
Echinococcus multilocularis fmrfamide receptor 0.0697 0.1616 0.1614
Schistosoma mansoni biogenic amine receptor 0.0697 0.1616 0.1614
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0035 0.0033
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0294 0.0663 0.0661
Loa Loa (eye worm) G-protein coupled receptor 0.0697 0.1616 0.734
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.0113 0.0463
Schistosoma mansoni tar DNA-binding protein 0.0065 0.012 0.0118
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0697 0.1616 0.1614
Echinococcus multilocularis mitogen activated protein kinase 3 0.0114 0.0236 0.0234
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0052 0.0087 0.0359
Brugia malayi hypothetical protein 0.0138 0.0292 0.1317
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.003 0.0037 0.0146
Loa Loa (eye worm) nuclear hormone receptor 0.0122 0.0254 0.1146
Mycobacterium leprae Probable polyketide synthase Pks1 0.0041 0.0063 0.1935
Schistosoma mansoni hypothetical protein 0.0053 0.0091 0.0089
Leishmania major importin beta-1 subunit, putative 0.0024 0.0023 0.0319
Schistosoma mansoni hypothetical protein 0.0053 0.0091 0.0089
Toxoplasma gondii ABC1 family protein 0.0036 0.0052 0.1155
Trypanosoma brucei unspecified product 0.0027 0.003 0.0392
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0697 0.1616 0.734
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0123 0.0257 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0236 0.1064
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0016 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0038
Loa Loa (eye worm) TYRA-2 protein 0.0697 0.1616 0.734
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0037 0.0146
Loa Loa (eye worm) hypothetical protein 0.0062 0.0113 0.0505
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0043 0.0042
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.003 0.0392
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0059 0.0262
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0236 0.0983
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0052 0.0968
Leishmania major hypothetical protein, conserved 0.003 0.0037 0.0504
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0044 0.5
Brugia malayi beta-NAC-like protein 0.0084 0.0165 0.0742
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0165 0.0684
Mycobacterium ulcerans polyketide synthase Pks9 0.0026 0.0026 0.0663
Brugia malayi MH2 domain containing protein 0.0035 0.0049 0.0212
Brugia malayi ecdysteroid receptor 0.0062 0.0113 0.0505
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.0113 0.0111
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0073 0.0975
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0019 0.0256
Brugia malayi hypothetical protein 0.0697 0.1616 0.734
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0019 0.0256
Echinococcus multilocularis neuropeptide FF receptor 2 0.0697 0.1616 0.1614
Onchocerca volvulus 0.0059 0.0106 0.0435
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Loa Loa (eye worm) hypothetical protein 0.0036 0.0052 0.0226
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0044 0.0601
Leishmania major hypothetical protein, conserved 0.0025 0.0023 0.0322
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.0726 0.3294
Loa Loa (eye worm) hypothetical protein 0.0033 0.0043 0.0189
Loa Loa (eye worm) hypothetical protein 0.0033 0.0043 0.0189
Loa Loa (eye worm) hypothetical protein 0.0062 0.0113 0.0505
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0019 0.046
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0139 0.3763
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0326 0.4482
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0151
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0019 0.046
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.0516 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0019 0.0327
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.003 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0151
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0049 0.0047
Loa Loa (eye worm) RNA binding protein 0.0065 0.012 0.0536
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0091 0.0404
Loa Loa (eye worm) PDE1B protein 0.0562 0.1296 0.5885
Echinococcus granulosus lamin dm0 0.0059 0.0106 0.0104
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0044 0.0042
Echinococcus multilocularis dro:myosuppressin receptor 0.0697 0.1616 0.1614
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.0113 0.0505
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.0113 0.0505
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0037 0.0504
Mycobacterium leprae putative cytochrome p450 0.0022 0.0019 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0038
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Echinococcus granulosus neuropeptide FF receptor 2 0.0697 0.1616 0.1614
Loa Loa (eye worm) hypothetical protein 0.0065 0.0119 0.0534
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0114 0.0236 0.3247
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0091 0.0404
Schistosoma mansoni DNA polymerase eta 0.004 0.0059 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.0113 0.0505
Echinococcus multilocularis rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0151
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0697 0.1616 0.1614
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0139 0.3763
Brugia malayi isocitrate dehydrogenase 0.0033 0.0044 0.0191
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0019 0.0327
Echinococcus granulosus rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Schistosoma mansoni growth hormone secretagogue receptor 0.0697 0.1616 0.1614
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0697 0.1616 0.1614
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Schistosoma mansoni tar DNA-binding protein 0.0065 0.012 0.0118
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0031 0.0039 0.1023
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0132
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.001 0.0008
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.0257 0.1159
Echinococcus granulosus smad 0.0035 0.0049 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0236 0.0983
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0197 0.0432 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0044 0.0578
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0059 0.0794
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0037 0.048
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0697 0.1616 0.1614
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0089 0.0177 0.0733
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.0113 0.0505
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0019 0.046
Echinococcus multilocularis mothers against decapentaplegic 6 0.0016 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.0053 0.0091 0.0089
Brugia malayi MAP kinase sur-1 0.0114 0.0236 0.1066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0057 0.0251
Brugia malayi hypothetical protein 0.0033 0.0043 0.0189
Schistosoma mansoni survival motor neuron protein 0.0055 0.0095 0.0093
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0031 0.0039 0.0953
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0019 0.0231
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0897 0.2092 0.9504
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0003
Schistosoma mansoni zinc finger protein 0.0029 0.0035 0.0033
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0052 0.005
Schistosoma mansoni smad 0.0016 0.0003 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0113 0.0505
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0019 0.0076
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0035 0.0151
Echinococcus granulosus flap endonuclease 1 0.0019 0.0011 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0096 0.1319
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0023 0.0322
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0697 0.1616 0.1614
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.001 0.0141
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0035 0.0151
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.003 0.0037 0.0158
Brugia malayi hypothetical protein 0.0016 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.0113 0.0505
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0035 0.0033
Loa Loa (eye worm) adenylyl cyclase 3 0.0199 0.0438 0.1984
Loa Loa (eye worm) hypothetical protein 0.0062 0.0113 0.0505
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0057 0.1511
Loa Loa (eye worm) hypothetical protein 0.0175 0.0381 0.1722
Echinococcus granulosus fmrfamide receptor 0.0697 0.1616 0.1614
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0037 0.0054 0.102
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.0794
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0052 0.0226
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0003 0.0003
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0018 0.0073
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0002 0.0025
Plasmodium falciparum GAF domain-related protein, putative 0.0021 0.0016 0.0884
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0068
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0697 0.1616 0.1614
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.0435 0.0433
Brugia malayi hypothetical protein 0.0033 0.0043 0.0189
Brugia malayi Pre-SET motif family protein 0.0897 0.2092 0.9504
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0022 0.0017 0.0305
Leishmania major protein kinase, putative 0.0018 0.0008 0.0116
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0697 0.1616 0.1614
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0019 0.046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0052 0.005
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0697 0.1616 0.1614
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.0367 0.71
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0697 0.1616 0.1614
Brugia malayi G protein-coupled receptor 0.0697 0.1616 0.734
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0039 0.0057 0.1074
Leishmania major GTP-binding protein, putative 0.0022 0.0018 0.0245
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0106 0.0475
Plasmodium falciparum basic transcription factor 3b, putative 0.0084 0.0165 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0019 0.046
Loa Loa (eye worm) flap endonuclease-1 0.0019 0.0011 0.0041
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.0113 0.0111
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.0113 0.0111
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Schistosoma mansoni amine GPCR 0.0697 0.1616 0.1614
Brugia malayi beta-lactamase family protein 0.0036 0.0052 0.0226
Brugia malayi hypothetical protein 0.0113 0.0233 0.1049
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0019 0.0256
Schistosoma mansoni neuropeptide receptor 0.0697 0.1616 0.1614
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0033 0.0143
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.003 0.0037 0.0146
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0697 0.1616 0.734
Schistosoma mansoni lipoxygenase 0.0022 0.0017 0.0016
Brugia malayi jmjC domain containing protein 0.0019 0.001 0.0038
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0059 0.0262
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0004 0.0002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0697 0.1616 0.1614
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0052 0.0709
Plasmodium falciparum importin beta, putative 0.003 0.0037 0.2137
Brugia malayi G-protein coupled receptor 0.0697 0.1616 0.734
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0091 0.0089
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0043 0.0042
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.001 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0236 0.0234
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0044 0.0191
Brugia malayi hypothetical protein 0.0022 0.0017 0.0071
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.0817
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0697 0.1616 0.1614
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0044 0.2571
Brugia malayi Protein kinase domain containing protein 0.0017 0.0006 0.0021
Brugia malayi RE15519p 0.0697 0.1616 0.734
Brugia malayi Cytochrome P450 family protein 0.0022 0.0019 0.0076
Schistosoma mansoni neuropeptide f receptor 76f 0.0697 0.1616 0.1614
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.003 0.0037 0.0035
Echinococcus granulosus snurportin 1 0.0321 0.0726 0.0724
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0697 0.1616 0.734
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.0113 0.0111
Echinococcus granulosus death domain containing protein 0.0016 0.0004 0.0002
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0052 0.0087 0.0359
Schistosoma mansoni neuropeptide receptor 0.0697 0.1616 0.1614
Schistosoma mansoni hypothetical protein 0.0697 0.1616 0.1614
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0089 0.0177 0.0733
Onchocerca volvulus Fatty acid synthase homolog 0.007 0.0131 0.0537
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.027 0.0269
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0003 0.0003
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0006 0.0018
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0153 0.0329 0.0327
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0002 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0028 0.0031 0.0572
Schistosoma mansoni rab6-interacting 0.0022 0.0017 0.0016
Loa Loa (eye worm) Smad1 0.0035 0.0049 0.0212
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0113 0.0111
Echinococcus multilocularis neuropeptide receptor A26 0.1535 0.3603 0.3602
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Echinococcus granulosus neuropeptide receptor A26 0.1535 0.3603 0.3602
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.0817
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0697 0.1616 0.1614
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0129 0.027 0.0269
Echinococcus granulosus tachykinin peptides receptor 99D 0.0697 0.1616 0.1614
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0071
Toxoplasma gondii hypothetical protein 0.0059 0.0105 0.2404
Brugia malayi hypothetical protein 0.0697 0.1616 0.734
Echinococcus granulosus nuclear factor of activated T cells 5 0.0083 0.0163 0.0161
Giardia lamblia DINP protein human, muc B family 0.004 0.0059 0.2457
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0044 0.0982
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.0233 0.0231
Toxoplasma gondii hypothetical protein 0.0052 0.0088 0.2009
Entamoeba histolytica hypothetical protein 0.0113 0.0233 0.7064
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.003 0.0037 0.048
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0113 0.0505
Schistosoma mansoni lamin 0.0059 0.0106 0.0104
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0019 0.046
Mycobacterium ulcerans thioesterase TesA 0.0032 0.0042 0.1095
Schistosoma mansoni opsin-like receptor 0.0697 0.1616 0.1614
Schistosoma mansoni amine GPCR 0.0697 0.1616 0.1614
Schistosoma mansoni amine GPCR 0.0697 0.1616 0.1614
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0019 0.0017
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0114 0.0236 0.3247
Loa Loa (eye worm) hypothetical protein 0.0062 0.0113 0.0505
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.003 0.0037 0.0158
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0112 0.0502
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0018 0.0245
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0019 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0105 0.0434
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0032 0.004 0.0749
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0134 0.0132
Brugia malayi TAR-binding protein 0.0065 0.012 0.0536
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0044 0.0974
Brugia malayi conserved hypotetical protein 0.0029 0.0035 0.0151
Brugia malayi acetyltransferase, GNAT family protein 0.0294 0.0663 0.3005
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0006 0.0018
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0021 0.0016 0.028
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0044 0.1659
Brugia malayi Importin beta-1 subunit 0.003 0.0037 0.0158
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.012 0.0536
Loa Loa (eye worm) acyl carrier protein 0.0018 0.0008 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.0113 0.0505
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0059 0.1578
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0059 0.1578
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0151
Brugia malayi Cytochrome P450 family protein 0.0062 0.0112 0.0502
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0019 0.0327
Echinococcus granulosus geminin 0.0413 0.0945 0.0943
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0257 0.1069
Echinococcus multilocularis GPCR, family 2 0.0053 0.0091 0.0089
Mycobacterium tuberculosis Conserved protein 0.0036 0.0052 0.0968
Echinococcus multilocularis 6 phosphofructokinase 0.0123 0.0257 0.0255
Onchocerca volvulus 0.0697 0.1616 0.6769
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0057 0.0055
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0134 0.0132
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Echinococcus granulosus adenylate cyclase 9 0.0084 0.0165 0.0164
Onchocerca volvulus 0.0036 0.0051 0.0203
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.0113 0.0111
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0167 0.0361 0.1634
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0059 0.0242
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0019 0.0327
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.003 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0017 0.0016
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0044 0.0601
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0158
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0037 0.2135
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.003 0.0037 0.1485
Echinococcus granulosus peptide allatostatin:somatostatin 0.0697 0.1616 0.1614
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.001 0.0008
Schistosoma mansoni hypothetical protein 0.0055 0.0095 0.0093
Echinococcus multilocularis microtubule associated protein 2 0.4235 1 1
Schistosoma mansoni intermediate filament proteins 0.0059 0.0106 0.0104
Echinococcus granulosus transcription factor btf3 0.0084 0.0165 0.0163
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0018 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0037 0.0504
Onchocerca volvulus 0.0697 0.1616 0.6769
Echinococcus multilocularis serotonin receptor 0.0697 0.1616 0.1614
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.087 0.2028 0.2027
Onchocerca volvulus 0.0067 0.0125 0.0513
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0158
Echinococcus multilocularis mitogen activated protein kinase 0.0114 0.0236 0.0234
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0158
Echinococcus granulosus mothers against decapentaplegic 6 0.0016 0.0003 0.0001
Trypanosoma brucei unspecified product 0.0027 0.003 0.0392
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0052 0.1155
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0035 0.0033
Schistosoma mansoni neuropeptide receptor 0.0697 0.1616 0.1614
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0044 0.5
Onchocerca volvulus 0.0055 0.0095 0.0386
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.003 0.0037 0.0146
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0697 0.1616 0.734
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0697 0.1616 0.1614
Schistosoma mansoni nuclear receptor 0.0029 0.0035 0.0033
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0155 0.0332 0.033
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0035 0.0033
Echinococcus multilocularis neuropeptide Y receptor 0.0697 0.1616 0.1614
Brugia malayi Dopamine receptor 0.0697 0.1616 0.734
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0084 0.0165 0.0684
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.001 0.0008
Echinococcus granulosus g protein coupled receptor 0.0697 0.1616 0.1614
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.003 0.0037 0.0158
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0004 0.0002
Echinococcus multilocularis orexin receptor type 2 0.0697 0.1616 0.1614
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0044 0.0177
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0129 0.027 0.0269
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0037 0.048
Mycobacterium leprae Probable lipase LipE 0.0036 0.0052 0.147
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0697 0.1616 0.1614
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0697 0.1616 0.1614
Onchocerca volvulus 0.0697 0.1616 0.6769
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0052 0.0209
Brugia malayi GnHR receptor homolog 0.0697 0.1616 0.734
Schistosoma mansoni ran 0.0022 0.0018 0.0016
Schistosoma mansoni neuropeptide F-like receptor 0.0697 0.1616 0.1614
Schistosoma mansoni hypothetical protein 0.0413 0.0945 0.0943
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0697 0.1616 0.1614
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0017 0.0071
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0084 0.0165 0.0684
Schistosoma mansoni ran 0.0022 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0035 0.0033
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0089 0.0177 0.0733
Echinococcus granulosus somatostatin receptor 0.0697 0.1616 0.1614
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0073 0.0997
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.0113 0.0111
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0017 0.0361
Echinococcus multilocularis lamin 0.0059 0.0106 0.0104
Brugia malayi hypothetical protein 0.0697 0.1616 0.734
Brugia malayi jmjC domain containing protein 0.0019 0.001 0.0038
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0052 0.1363
Echinococcus granulosus RUN 0.0022 0.0017 0.0016
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0023 0.0503
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0139 0.0137
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0021 0.0016 0.028
Echinococcus multilocularis importin subunit beta 1 0.003 0.0037 0.0035
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0052 0.147
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0562 0.1296 0.1294
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.0113 0.0505
Loa Loa (eye worm) hypothetical protein 0.0125 0.0262 0.1184
Brugia malayi intermediate filament protein 0.0059 0.0106 0.0475
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0114 0.0236 0.3247
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.001 0.0008
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0039 0.0057 0.1513
Schistosoma mansoni microtubule-associated protein tau 0.4235 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0151
Plasmodium vivax basic transcription factor 3b, putative 0.0084 0.0165 0.3787
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0019 0.0076
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0052 0.0209
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0236 0.0983
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0091 0.0089
Echinococcus multilocularis g protein coupled receptor 0.0697 0.1616 0.1614
Brugia malayi ecdysone receptor 0.0029 0.0035 0.0151
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0035 0.0033
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0019 0.046
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0197 0.0432 0.5944
Echinococcus granulosus rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.0113 0.0505
Entamoeba histolytica hypothetical protein 0.0084 0.0165 0.4992
Loa Loa (eye worm) DR-78 0.0029 0.0035 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0043 0.0189
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0018 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0105 0.0434
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.0233 0.0231
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0019 0.0327
Schistosoma mansoni smad1 5 8 and 0.0035 0.0049 0.0047
Trichomonas vaginalis esterase, putative 0.0036 0.0052 0.0209
Brugia malayi Doublecortin family protein 0.0022 0.0017 0.0071
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0197 0.0432 0.0431
Echinococcus multilocularis dna polymerase kappa 0.004 0.0059 0.0058
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0052 0.0087 0.0086
Onchocerca volvulus 0.0059 0.0106 0.0435
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.001 0.0008
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0035 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.0113 0.0505
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0294 0.0663 0.0661
Brugia malayi nuclear receptor NHR-88 0.0062 0.0113 0.0505
Brugia malayi MH1 domain containing protein 0.0035 0.0049 0.0212
Loa Loa (eye worm) cytochrome P450 0.0022 0.0019 0.0076
Brugia malayi G protein-coupled receptor F59B2.13 0.0697 0.1616 0.734
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0019 0.046
Schistosoma mansoni opsin-like receptor 0.0697 0.1616 0.1614
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Brugia malayi nuclear receptor NHR-88 0.0029 0.0035 0.0151
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0114 0.0236 0.1066
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0053 0.0091 0.0404
Mycobacterium ulcerans polyketide synthase 0.0041 0.0063 0.1669
Brugia malayi MH1 domain containing protein 0.0035 0.0049 0.0212
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0089 0.0177 0.2408
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0002 0.0025
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0035 0.0033
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0153 0.0329 0.1486
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0113 0.0111
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0562 0.1296 0.5885
Entamoeba histolytica hypothetical protein 0.0113 0.0233 0.7064
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.0794
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0198 0.0435 0.0433
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0004 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0113 0.0111
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0095 0.0422
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0019 0.0231
Loa Loa (eye worm) hypothetical protein 0.0165 0.0357 0.1616
Entamoeba histolytica hypothetical protein 0.0113 0.0233 0.7064
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Brugia malayi phosphofructokinase 0.0123 0.0257 0.1159
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0037 0.0035
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0041 0.0063 0.1185
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0043 0.0189
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0006 0.0018
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0049 0.0212
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0044 0.0974
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0089 0.0177 0.0175
Loa Loa (eye worm) hypothetical protein 0.0167 0.0361 0.1634
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0052 0.0968
Echinococcus multilocularis rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Loa Loa (eye worm) hypothetical protein 0.0062 0.0113 0.0505
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0089 0.0177 0.2427
Trypanosoma cruzi transcription factor btf3, putative 0.0084 0.0165 0.2267
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.001 0.0197
Onchocerca volvulus 0.0697 0.1616 0.6769
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0017 0.0016
Brugia malayi jmjC domain containing protein 0.0019 0.001 0.0038
Brugia malayi Cytochrome P450 family protein 0.0022 0.0019 0.0076
Loa Loa (eye worm) hypothetical protein 0.0036 0.0052 0.0226
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0697 0.1616 0.1614
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.0113 0.0111
Echinococcus multilocularis G-protein coupled receptor, putative 0.0697 0.1616 0.1614
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0035 0.0151
Echinococcus granulosus tm gpcr rhodopsin 0.0697 0.1616 0.1614
Schistosoma mansoni neuropeptide receptor 0.0697 0.1616 0.1614
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.001 0.0519
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.003 0.0037 0.0035
Trypanosoma cruzi transcription factor btf3, putative 0.0084 0.0165 0.2267
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0052 0.0686
Echinococcus granulosus biogenic amine 5HT receptor 0.0697 0.1616 0.1614
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0018 0.0245
Brugia malayi larval opioid receptor 0.0697 0.1616 0.734
Onchocerca volvulus 0.0697 0.1616 0.6769
Toxoplasma gondii hypothetical protein 0.0021 0.0016 0.0335
Mycobacterium ulcerans hypothetical protein 0.0169 0.0367 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0089 0.0177 0.0175
Echinococcus multilocularis adenylate cyclase type IX 0.0119 0.0247 0.0245
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0037 0.2135
Schistosoma mansoni amine GPCR 0.0697 0.1616 0.1614
Brugia malayi hypothetical protein 0.0267 0.0599 0.2715
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0089 0.0177 0.0733
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0091 0.0089
Schistosoma mansoni flap endonuclease-1 0.0017 0.0006 0.0005
Giardia lamblia hypothetical protein 0.003 0.0037 0.1485
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0114 0.0236 0.3247
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0197 0.0432 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0037 0.0809
Schistosoma mansoni tar DNA-binding protein 0.0065 0.012 0.0118
Echinococcus granulosus G protein coupled receptor 139 0.0697 0.1616 0.1614
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0562 0.1296 0.1294
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0052 0.0209
Schistosoma mansoni neuropeptide F-like receptor 0.0697 0.1616 0.1614
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Toxoplasma gondii hypothetical protein 0.0021 0.0016 0.0335
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0049 0.0212
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Schistosoma mansoni myosin xvIII 0.0697 0.1616 0.1614
Onchocerca volvulus 0.0129 0.027 0.1124
Leishmania major hypothetical protein, conserved 0.003 0.0037 0.0504
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0037 0.0504
Echinococcus multilocularis lamin dm0 0.0059 0.0106 0.0104
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.003 0.0037 0.0146
Onchocerca volvulus 0.0697 0.1616 0.6769
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0052 0.0226
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0083 0.0163 0.0161
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0059 0.0817
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0037 0.0035
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0035 0.0151
Schistosoma mansoni alpha-1 adrenergic receptor 0.0697 0.1616 0.1614
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0089 0.0177 0.0733
Plasmodium falciparum phosphodiesterase gamma, putative 0.003 0.0037 0.2135
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0697 0.1616 0.1614
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0026 0.0026 0.0663
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.0113 0.0111
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0019 0.0256
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0059 0.0817
Schistosoma mansoni jumonji domain containing protein 0.0019 0.001 0.0008
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0044 0.0816
Echinococcus multilocularis neuropeptide receptor 0.0697 0.1616 0.1614
Brugia malayi putative neuropeptide receptor 0.0697 0.1616 0.734
Leishmania major hypothetical protein, conserved 0.0036 0.0052 0.0709
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.0113 0.0111
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0134 0.0132
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Echinococcus granulosus neuropeptide Y receptor 0.0697 0.1616 0.1614
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0044 0.0601
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0017 0.0016
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0052 0.0087 0.0086
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.003 0.0037 0.0146
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0021 0.0016 0.0395
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0326 0.4482
Toxoplasma gondii GAF domain-containing protein 0.0021 0.0016 0.0335
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Loa Loa (eye worm) melatonin receptor type 1A 0.0697 0.1616 0.734
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0039 0.0057 0.1698
Loa Loa (eye worm) hypothetical protein 0.0058 0.0104 0.0463
Brugia malayi MH1 domain containing protein 0.0019 0.0011 0.0044
Mycobacterium ulcerans 6-phosphofructokinase 0.0123 0.0257 0.6982
Schistosoma mansoni coup transcription factor 0.0062 0.0113 0.0111
Echinococcus granulosus phd:f box containing protein 0.0019 0.001 0.0008
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.003 0.0037 0.0035
Echinococcus multilocularis rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.0257 0.78
Plasmodium vivax SET domain protein, putative 0.0129 0.027 0.6238
Brugia malayi MH2 domain containing protein 0.0016 0.0003 0.0003
Brugia malayi Uncoordinated protein 44 0.0016 0.0004 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0044 0.0177
Loa Loa (eye worm) TAR-binding protein 0.0065 0.012 0.0536
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0049 0.0047
Brugia malayi Pre-SET motif family protein 0.0129 0.027 0.1221
Loa Loa (eye worm) hypothetical protein 0.0062 0.0113 0.0505
Brugia malayi follicle stimulating hormone receptor 0.0943 0.2201 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0019 0.0076
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0019 0.0327
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0058 0.0102 0.1956
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Schistosoma mansoni hypothetical protein 0.0022 0.0017 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0113 0.0505
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.003 0.0037 0.0035
Plasmodium vivax importin-beta 2, putative 0.003 0.0037 0.0809
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0943 0.2201 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.001 0.0117
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0089 0.0177 0.2408
Schistosoma mansoni hypothetical protein 0.0697 0.1616 0.1614
Leishmania major hypothetical protein, conserved 0.0019 0.001 0.0141
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.0113 0.0111
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0039 0.0057 0.1074
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0023 0.009
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0019 0.0099
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.017 0.3916
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0052 0.0209
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.017 0.3916
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0236 0.0983
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0033 0.0032
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0019 0.0327
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.017 0.0169
Loa Loa (eye worm) phosphofructokinase 0.0123 0.0257 0.1159
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0113 0.0111
Giardia lamblia Kinase, CMGC MAPK 0.0114 0.0236 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0129 0.027 0.0269
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0052 0.005
Brugia malayi hypothetical protein 0.0175 0.0381 0.1722
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.017 0.3916
Onchocerca volvulus 0.0036 0.0052 0.0206
Entamoeba histolytica Flap nuclease, putative 0.0019 0.0011 0.0276
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0019 0.046
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0089 0.0177 0.2427
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.003 0.0037 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0065 0.012 0.0118
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0697 0.1616 0.1614
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0035 0.0033
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0044 0.2592
Echinococcus granulosus neuropeptide s receptor 0.1535 0.3603 0.3602
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0697 0.1616 0.1614
Brugia malayi hypothetical protein 0.0697 0.1616 0.734
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0697 0.1616 0.1614
Schistosoma mansoni rab6-interacting 0.0022 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0151
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0198 0.0435 0.0433
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.0727 1
Brugia malayi Serotonin receptor 0.0697 0.1616 0.734
Echinococcus granulosus neuropeptides capa receptor 0.0697 0.1616 0.1614
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0197 0.0432 0.5934
Onchocerca volvulus 0.0036 0.0052 0.0206
Echinococcus multilocularis transcription factor btf3 0.0084 0.0165 0.0163
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0019 0.0327
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0052 0.0709
Brugia malayi 6-phosphofructokinase 0.0123 0.0257 0.1159
Schistosoma mansoni opsin-like receptor 0.0697 0.1616 0.1614
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.0113 0.0463
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.0794
Leishmania major cAMP-specific phosphodiesterase, putative 0.003 0.0037 0.0504
Echinococcus multilocularis adenylate cyclase 9 0.0084 0.0165 0.0164
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0113 0.0111
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0035 0.0151
Leishmania major DNA polymerase eta, putative 0.004 0.0059 0.0817
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0697 0.1616 0.1614
Echinococcus multilocularis smad 0.0035 0.0049 0.0047
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0019 0.0327
Giardia lamblia Hypothetical protein 0.003 0.0037 0.1485
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.003 0.0037 0.0146
Echinococcus multilocularis phd:f box containing protein 0.0019 0.001 0.0008
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0019 0.0256
Schistosoma mansoni smad1 5 8 and 0.0035 0.0049 0.0047
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0019 0.0327
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0153 0.4638
Schistosoma mansoni hypothetical protein 0.029 0.0652 0.065
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.0113 0.0463
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0059 0.0794
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0035 0.0033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0697 0.1616 0.1614
Brugia malayi photoreceptor-specific nuclear receptor 0.0062 0.0113 0.0505
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.012 0.0536
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0044 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0051 0.0224
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.003 0.0037 0.0158
Echinococcus granulosus Solute carrier family 22 5 0.1123 0.2626 0.2625
Brugia malayi Calcitonin receptor-like protein seb-1 0.0167 0.0361 0.1634
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0113 0.0505
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0019 0.0011 0.0124
Plasmodium falciparum cGMP-specific phosphodiesterase 0.003 0.0037 0.2135
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0114 0.0236 0.3247
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0018 0.0372
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0035 0.0033
Brugia malayi Death domain containing protein 0.0016 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Schistosoma mansoni amine GPCR 0.0697 0.1616 0.1614
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0153 0.9292
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0089 0.0177 0.0733
Loa Loa (eye worm) neuropeptide F receptor 0.0697 0.1616 0.734
Echinococcus multilocularis tar DNA binding protein 0.0065 0.012 0.0118
Loa Loa (eye worm) hypothetical protein 0.0036 0.0052 0.0226
Echinococcus multilocularis Smad4 0.0035 0.0049 0.0047
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0089 0.0177 0.0733
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0073 0.0139 0.0624
Echinococcus granulosus 6 phosphofructokinase 0.0123 0.0257 0.0255
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0016 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0037 0.0146
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0167 0.0361 0.1634
Brugia malayi PAS domain containing protein 0.0052 0.0089 0.0397
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0023 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.0113 0.0505
Mycobacterium ulcerans Type I modular polyketide synthase 0.0039 0.0057 0.1513
Brugia malayi cytochrome P450 0.0022 0.0019 0.0076
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.017 0.0707
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0041 0.0178
Echinococcus multilocularis g-protein coupled receptor 0.0697 0.1616 0.1614
Echinococcus multilocularis Ankyrin 0.0016 0.0004 0.0002
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0134 0.0132
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0044 0.0042
Echinococcus multilocularis somatostatin receptor 0.0697 0.1616 0.1614
Echinococcus multilocularis sex peptide receptor 0.0697 0.1616 0.1614
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0155 0.0332 0.033
Onchocerca volvulus 0.0697 0.1616 0.6769
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0039 0.0057 0.1698
Schistosoma mansoni adenoreceptor 0.0697 0.1616 0.1614
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0124 0.0259 0.0257
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0697 0.1616 0.734
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0151
Echinococcus granulosus Smad4 0.0035 0.0049 0.0047
Leishmania major basic transcription factor 3a, putative 0.0084 0.0165 0.2267
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0151
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.001 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0697 0.1616 0.1614
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.017 0.0707
Echinococcus granulosus alpha 1A adrenergic receptor 0.0697 0.1616 0.1614
Echinococcus multilocularis 0.0022 0.0019 0.0017
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0197 0.0432 0.0431
Echinococcus multilocularis musashi 0.0059 0.0106 0.0104
Echinococcus granulosus 7tm_1 domain containing protein 0.0697 0.1616 0.1614
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.003 0.0392
Entamoeba histolytica transcription factor BTF3, putative 0.0084 0.0165 0.4992
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.001 0.0008
Brugia malayi nuclear receptor NHR-67 0.0029 0.0035 0.0151
Echinococcus granulosus g protein coupled receptor 0.0697 0.1616 0.1614
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0037 0.048
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0153 0.6465
Loa Loa (eye worm) hypothetical protein 0.004 0.0059 0.0262
Brugia malayi Dopamine receptor protein 1 0.0697 0.1616 0.734
Schistosoma mansoni hypothetical protein 0.0697 0.1616 0.1614
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0153 0.0329 0.4502
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0177 0.0733
Brugia malayi Cytochrome P450 family protein 0.0022 0.0019 0.0076
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0044 0.0578
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0052 0.0087 0.0389
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0059 0.112
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0018 0.0372
Schistosoma mansoni hypothetical protein 0.0114 0.0236 0.0234
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0016 0.0395
Brugia malayi putative neuropeptide receptor NPR1 0.0697 0.1616 0.734
Loa Loa (eye worm) hypothetical protein 0.0062 0.0113 0.0505
Loa Loa (eye worm) hypothetical protein 0.0697 0.1616 0.734
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0697 0.1616 0.1614
Schistosoma mansoni Smad4 0.0016 0.0003 0.0001
Echinococcus granulosus orexin receptor type 2 0.0697 0.1616 0.1614
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0016 0.006
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0043 0.0042
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0697 0.1616 0.1614
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0697 0.1616 0.6769
Loa Loa (eye worm) ICD-1 protein 0.0084 0.0165 0.0742
Echinococcus granulosus rhodopsin orphan GPCR 0.0697 0.1616 0.1614
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0052 0.0968
Echinococcus granulosus neuropeptide receptor 0.0697 0.1616 0.1614
Onchocerca volvulus 0.0697 0.1616 0.6769

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0112 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 1.8356 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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