Detailed information for compound 1344912

Basic information

Technical information
  • TDR Targets ID: 1344912
  • Name: 1-cyclohexyl-4-oxoquinoline-3-carboxamide
  • MW: 270.326 | Formula: C16H18N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.14 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)c1cn(C2CCCCC2)c2c(c1=O)cccc2
  • InChi: 1S/C16H18N2O2/c17-16(20)13-10-18(11-6-2-1-3-7-11)14-9-5-4-8-12(14)15(13)19/h4-5,8-11H,1-3,6-7H2,(H2,17,20)
  • InChiKey: DFIWDFFBFHYEFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-cyclohexyl-4-oxo-quinoline-3-carboxamide
  • 1-cyclohexyl-4-oxo-3-quinolinecarboxamide
  • 1-cyclohexyl-4-keto-quinoline-3-carboxamide
  • IDI1_016809
  • Oprea1_848799
  • ZINC00086313
  • Maybridge3_005422

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor NHR-88 0.0032 0.0012 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.006 0.0205
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0018 0.0011
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.1225 0.1125 0.3353
Plasmodium vivax hexokinase, putative 0.0082 0.0059 0.0199
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.003 0.0054
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0018 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3585 0.3324 1
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0106 0.0081 0.0281
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0712 0.0646 0.1162
Schistosoma mansoni hypothetical protein 0.0713 0.0647 0.1163
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0074 0.0133
Entamoeba histolytica cysteine protease, putative 0.3099 0.2872 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.0098 0.0074 0.0132
Echinococcus granulosus heat shock protein 90 0.0035 0.0015 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0016 0.0008
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0002 0.0003
Entamoeba histolytica cysteine protease, putative 0.0712 0.0646 0.2244
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.1687 0.1555 0.2794
Loa Loa (eye worm) hypothetical protein 0.0098 0.0074 0.0132
Echinococcus multilocularis hexokinase type 2 0.0082 0.0059 0.0106
Entamoeba histolytica cysteine protease, putative 0.1687 0.1555 0.5411
Schistosoma mansoni transcription factor btf3 0.0037 0.0017 0.0031
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0029 0.0064
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0002 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.3099 0.2872 1
Onchocerca volvulus 0.0227 0.0194 0.0675
Plasmodium vivax unspecified product 0.0975 0.0891 0.3098
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0867 0.0791 0.2751
Schistosoma mansoni inositol monophosphatase 0.0039 0.0019 0.0034
Schistosoma mansoni hypothetical protein 0.0074 0.0052 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0712 0.0646 0.2248
Schistosoma mansoni ubiquitin-activating enzyme E1 0.0027 0.0008 0.0013
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.0124 0.0368
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0124 0.0221
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Entamoeba histolytica hypothetical protein 0.0037 0.0017 0.0053
Onchocerca volvulus 0.3099 0.2872 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0019 0.0152
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0017 0.0046
Echinococcus granulosus dnaJ subfamily B 0.0494 0.0443 0.0796
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0093 0.0069 0.0184
Entamoeba histolytica protein kinase domain containing protein 0.0093 0.0069 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.3099 0.2872 1
Echinococcus multilocularis hexokinase 0.0082 0.0059 0.0106
Trypanosoma brucei heat shock protein, putative 0.0035 0.0015 0.0038
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0002 0.0003
Toxoplasma gondii hypothetical protein 0.0052 0.0031 0.01
Trypanosoma cruzi DNA repair protein, putative 0.0105 0.0081 0.0142
Plasmodium vivax SET domain protein, putative 0.0032 0.0012 0.0036
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.0008 0.0012
Echinococcus multilocularis protein dispatched 1 0.0052 0.0031 0.0055
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.006 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0008 0.0019
Brugia malayi HSF-type DNA-binding domain containing protein 0.0106 0.0081 0.0145
Trypanosoma cruzi cysteine proteinase, putative 0.1687 0.1555 0.2794
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0066 0.0044 0.0036
Plasmodium falciparum serine repeat antigen 2 0.0712 0.0646 0.2244
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0003
Giardia lamblia Cathepsin L-like protease 0.0712 0.0646 0.2976
Entamoeba histolytica hexokinase 2 0.0082 0.0059 0.0199
Loa Loa (eye worm) hypothetical protein 0.0712 0.0646 0.1162
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0012 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.3099 0.2872 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0867 0.0791 0.1421
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.002 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.3099 0.2872 1
Entamoeba histolytica heat shock transcription factor, putative 0.0106 0.0081 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0002 0.0005
Entamoeba histolytica cysteine protease, putative 0.1687 0.1555 0.5411
Brugia malayi MoeZ/MoeB domain containing protein 0.0027 0.0008 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.002 0.0055
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0018 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0867 0.0791 0.2751
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0008 0.0019
Brugia malayi Cathepsin L-like precursor 0.3099 0.2872 0.5164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.3099 0.2872 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1687 0.1555 0.4674
Echinococcus multilocularis cysteine protease 0.3099 0.2872 0.5164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.3099 0.2872 1
Echinococcus granulosus heat shock protein 0.0035 0.0015 0.0026
Entamoeba histolytica rodhanase-like domain containing protein 0.0227 0.0194 0.0668
Loa Loa (eye worm) hypothetical protein 0.0106 0.0081 0.0145
Echinococcus granulosus cathepsin b 0.5984 0.556 1
Echinococcus multilocularis traf and tnf receptor associated protein 0.0184 0.0154 0.0276
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0002 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0017 0.001
Giardia lamblia Cathepsin L precursor 0.0712 0.0646 0.2976
Leishmania major cathepsin L-like protease 0.3099 0.2872 0.8636
Loa Loa (eye worm) hypothetical protein 0.0262 0.0226 0.0407
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0023 0.008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.3099 0.2872 1
Trypanosoma cruzi metacaspase, putative 0.0083 0.006 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.3099 0.2872 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0012 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0027 0.0049
Leishmania major DNA polymerase eta, putative 0.004 0.002 0.0036
Brugia malayi CXXC zinc finger family protein 0.0035 0.0015 0.0026
Trypanosoma cruzi major cysteine proteinase, putative 0.1197 0.1098 0.1973
Echinococcus multilocularis chromobox protein 1 0.0072 0.005 0.0089
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.002 0.0036
Schistosoma mansoni hypothetical protein 0.0044 0.0023 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0027 0.0049
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0023 0.0077
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0301 0.0263 0.0914
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0134 0.0108 0.0373
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0015 0.0008
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0227 0.0194 0.0672
Plasmodium vivax unspecified product 0.1687 0.1555 0.5411
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0114 0.0089 0.0159
Schistosoma mansoni cpg binding protein 0.0035 0.0015 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.006 0.0205
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0018 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.004 0.002 0.0067
Trichomonas vaginalis cdc25b, putative 0.0227 0.0194 0.0672
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0012 0.0022
Brugia malayi cathepsin Z-like cysteine proteinase 0.0867 0.0791 0.1421
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0712 0.0646 0.2248
Echinococcus granulosus cathepsin L cysteine proteinase 0.3099 0.2872 0.5164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.3099 0.2872 1
Schistosoma mansoni hypothetical protein 0.0051 0.003 0.0054
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0855 0.078 0.3594
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0012 0.0022
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0342 0.0301 0.2666
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0045 0.0025 0.0044
Echinococcus multilocularis geminin 0.0713 0.0647 0.1163
Onchocerca volvulus 0.3099 0.2872 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0712 0.0646 0.1162
Schistosoma mansoni topbp1 0.0021 0.0002 0.0003
Schistosoma mansoni chromobox protein 0.0072 0.005 0.0089
Schistosoma mansoni cpg binding protein 0.0037 0.0017 0.003
Plasmodium vivax ubiquitin activating enzyme, putative 0.0102 0.0077 0.0261
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0019 0.0059
Schistosoma mansoni heat shock protein 0.0035 0.0015 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0712 0.0646 0.2248
Trypanosoma cruzi cruzipain precursor, putative 0.0975 0.0891 0.16
Trypanosoma cruzi cruzipain precursor, putative 0.3585 0.3324 0.5977
Loa Loa (eye worm) hypothetical protein 0.0039 0.0018 0.0033
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.002 0.0013
Trypanosoma brucei heat shock protein, putative 0.0035 0.0015 0.0038
Brugia malayi TAR-binding protein 0.0134 0.0108 0.0193
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0017 0.0053
Echinococcus multilocularis cathepsin L cysteine protease 0.3099 0.2872 0.5164
Trypanosoma brucei heat shock protein, putative 0.0035 0.0015 0.0038
Mycobacterium tuberculosis Conserved protein 0.0039 0.0018 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0927 0.0846 0.2945
Schistosoma mansoni cathepsin F (C01 family) 0.3099 0.2872 0.5164
Echinococcus granulosus caspase 8 0.0083 0.006 0.0107
Loa Loa (eye worm) hypothetical protein 0.0039 0.0018 0.0033
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0037 0.0066
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0017 0.0053
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0012 0.0036
Schistosoma mansoni heat shock protein 0.0035 0.0015 0.0026
Entamoeba histolytica cysteine protease, putative 0.0712 0.0646 0.2244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0867 0.0791 0.2751
Loa Loa (eye worm) hypothetical protein 0.0039 0.0018 0.0033
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0012 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.0108 0.0373
Brugia malayi beta-NAC-like protein 0.0037 0.0017 0.0031
Echinococcus multilocularis sentrin specific protease 7 0.0555 0.05 0.0898
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0012 0.0022
Giardia lamblia Cathepsin L precursor 0.0712 0.0646 0.2976
Trypanosoma cruzi cysteine peptidase, putative 0.0975 0.0891 0.16
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0037 0.0066
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0012 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0009 0.0029
Loa Loa (eye worm) hypothetical protein 0.0252 0.0217 0.039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0927 0.0846 0.2945
Mycobacterium ulcerans DNA polymerase IV 0.004 0.002 0.0162
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0012 0.0043
Loa Loa (eye worm) beta-lactamase 0.0039 0.0018 0.0033
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Mycobacterium ulcerans beta-lactamase 0.0039 0.0018 0.0146
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.0078 0.014
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0712 0.0646 0.2244
Onchocerca volvulus Cathepsin L homolog 0.3099 0.2872 1
Brugia malayi Rhodanese-like domain containing protein 0.0227 0.0194 0.0348
Echinococcus granulosus sentrin specific protease 7 0.0555 0.05 0.0898
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0018 0.0062
Trypanosoma cruzi DNA repair protein, putative 0.0105 0.0081 0.0142
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0927 0.0846 0.2945
Trypanosoma cruzi cysteine protease, putative 0.1687 0.1555 0.2794
Brugia malayi Cathepsin L-like precursor 0.3099 0.2872 0.5164
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0712 0.0646 0.1162
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.261 0.2416 0.4343
Echinococcus granulosus sentrin specific protease 8 0.0301 0.0263 0.0473
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0927 0.0846 0.2945
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.3099 0.2872 1
Loa Loa (eye worm) hypothetical protein 0.0227 0.0194 0.0348
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0227 0.0194 0.0672
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0037 0.0017 0.003
Schistosoma mansoni hypothetical protein 0.0044 0.0023 0.0041
Echinococcus multilocularis tar DNA binding protein 0.0134 0.0108 0.0193
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0018 0.0049
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0927 0.0846 0.2945
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Brugia malayi ThiF family protein 0.0102 0.0077 0.0138
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0018 0.0146
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0039 0.0018 0.0033
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Brugia malayi Cathepsin L-like precursor 0.2125 0.1963 0.353
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0029 0.0095
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0034 0.006
Brugia malayi MH1 domain containing protein 0.0024 0.0004 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.3099 0.2872 1
Loa Loa (eye worm) hexokinase 0.0052 0.0031 0.0055
Mycobacterium leprae Conserved hypothetical protein 0.3613 0.335 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0012 0.0022
Chlamydia trachomatis replicative DNA helicase 0.1225 0.1125 1
Brugia malayi heat shock protein 90 0.0035 0.0015 0.0026
Trypanosoma brucei heat shock protein, putative 0.0035 0.0015 0.0038
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0301 0.0263 0.0914
Onchocerca volvulus 0.0039 0.0018 0.0064
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0023 0.0077
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0012 0.0022
Brugia malayi ThiF family protein 0.0067 0.0045 0.008
Onchocerca volvulus Huntingtin homolog 0.0262 0.0226 0.0789
Giardia lamblia Cathepsin L precursor 0.0712 0.0646 0.2976
Onchocerca volvulus 0.0242 0.0208 0.0723
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0041 0.0073
Schistosoma mansoni caspase-7 (C14 family) 0.031 0.0271 0.0487
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0227 0.0194 0.0348
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0018 0.0011
Giardia lamblia Cathepsin B precursor 0.0867 0.0791 0.3644
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0227 0.0194 0.0672
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.0074 0.0133
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0034 0.0077
Loa Loa (eye worm) papain family cysteine protease containing protein 0.3099 0.2872 0.5164
Loa Loa (eye worm) Smad1 0.0043 0.0022 0.004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0003
Onchocerca volvulus 0.0032 0.0012 0.0043
Brugia malayi steroid hormone receptor 0.0032 0.0012 0.0022
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0037 0.0066
Trichomonas vaginalis chromobox protein, putative 0.0072 0.005 0.017
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0301 0.0263 0.091
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0083 0.006 0.0107
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0029 0.0243
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0018 0.0031
Mycobacterium ulcerans hypothetical protein 0.0169 0.014 0.1231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3585 0.3324 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0019 0.0064
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0855 0.078 0.271
Schistosoma mansoni cathepsin F (C01 family) 0.2125 0.1963 0.353
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3585 0.3324 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0712 0.0646 0.1162
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0012 0.0022
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0012 0.0022
Schistosoma mansoni smad 0.0043 0.0022 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0712 0.0646 0.2248
Trypanosoma cruzi cysteine peptidase, putative 0.1687 0.1555 0.2794
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0712 0.0646 0.2244
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0003
Schistosoma mansoni SET domain protein 0.0037 0.0017 0.003
Loa Loa (eye worm) RNA binding protein 0.0134 0.0108 0.0193
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0134 0.0108 0.0193
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0134 0.0108 0.0193
Leishmania major cysteine peptidase A (CPA) 0.3099 0.2872 0.8636
Onchocerca volvulus 0.0098 0.0074 0.0256
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0712 0.0646 0.1162
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0102 0.0077 0.0138
Entamoeba histolytica cysteine protease, putative 0.1687 0.1555 0.5411
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0029 0.0081
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0712 0.0646 0.2244
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0029 0.0064
Brugia malayi Cell death protein 3 precursor 0.018 0.0151 0.0271
Plasmodium falciparum serine repeat antigen 3 0.0712 0.0646 0.2244
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0017 0.0058
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0227 0.0194 0.0348
Loa Loa (eye worm) hypothetical protein 0.004 0.002 0.0036
Leishmania major cathepsin L-like protease 0.3585 0.3324 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0041 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0108 0.0193
Echinococcus multilocularis cpg binding protein 0.0037 0.0017 0.003
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0017 0.0054
Brugia malayi Inositol-1 0.0039 0.0019 0.0034
Schistosoma mansoni hypothetical protein 0.0044 0.0023 0.0041
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0002 0.0005
Entamoeba histolytica cysteine protease, putative 0.1687 0.1555 0.5411
Brugia malayi AMP-binding enzyme family protein 0.005 0.0029 0.0052
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0022 0.004
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0012 0.0022
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0134 0.0108 0.0368
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0012 0.0022
Schistosoma mansoni inositol monophosphatase 0.0039 0.0019 0.0034
Giardia lamblia Sentrin specific protease, putative 0.0134 0.0108 0.0488
Trypanosoma brucei hexokinase 0.0082 0.0059 0.0172
Brugia malayi cathepsin L precursor 0.0712 0.0646 0.1162
Schistosoma mansoni cathepsin F (C01 family) 0.3099 0.2872 0.5164
Echinococcus granulosus hexokinase 0.0082 0.0059 0.0106
Schistosoma mansoni hypothetical protein 0.0044 0.0023 0.0041
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0034 0.0058
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.006 0.0205
Echinococcus granulosus hexokinase 0.0082 0.0059 0.0106
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0025 0.0044
Echinococcus granulosus caspase 3 0.0227 0.0194 0.0348
Trypanosoma brucei SUMO1/Ulp2, putative 0.0134 0.0108 0.0318
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0029 0.0095
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.0002 0.00000018824
Loa Loa (eye worm) hypothetical protein 0.0056 0.0035 0.0062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.3099 0.2872 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.002 0.0055
Trypanosoma cruzi cysteine peptidase, putative 0.3585 0.3324 0.5977
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0029 0.0243
Loa Loa (eye worm) fibroinase 0.3099 0.2872 0.5164
Trypanosoma brucei heat shock protein, putative 0.0035 0.0015 0.0038
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0025 0.0068
Entamoeba histolytica hypothetical protein 0.0074 0.0052 0.0173
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0 0.00000014448
Loa Loa (eye worm) transcription factor SMAD2 0.0626 0.0566 0.1017
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.002 0.0036
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0766 0.0697 0.2421
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0009 0.0029
Plasmodium falciparum serine repeat antigen 4 0.0712 0.0646 0.2244
Schistosoma mansoni hypothetical protein 0.0494 0.0443 0.0796
Mycobacterium ulcerans lipase LipD 0.0039 0.0018 0.0146
Entamoeba histolytica cysteine protease, putative 0.1687 0.1555 0.5411
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.006 0.0205
Entamoeba histolytica rodhanase-like domain containing protein 0.0227 0.0194 0.0668
Echinococcus granulosus cathepsin b 0.5984 0.556 1
Onchocerca volvulus 0.0082 0.0059 0.0206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0039 0.0069
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.3099 0.2872 1
Echinococcus multilocularis sentrin specific protease 1 0.0134 0.0108 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.3099 0.2872 1
Giardia lamblia Cathepsin B precursor 0.0712 0.0646 0.2976
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.035 0.0308 0.0554
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.006 0.0205
Loa Loa (eye worm) hypothetical protein 0.018 0.0151 0.0271
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.0069 0.0122
Trypanosoma cruzi hexokinase, putative 0.0082 0.0059 0.0104
Brugia malayi hypothetical protein 0.0098 0.0074 0.0132
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0227 0.0194 0.0672
Trypanosoma cruzi cysteine peptidase, putative 0.3585 0.3324 0.5977
Echinococcus granulosus hexokinase 0.0082 0.0059 0.0106
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.0108 0.0193
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0019 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0074 0.0256
Brugia malayi nuclear hormone receptor 0.0032 0.0012 0.0022
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0019 0.0033
Entamoeba histolytica cysteine protease, putative 0.1687 0.1555 0.5411
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0712 0.0646 0.2244
Giardia lamblia Cathepsin L precursor 0.0712 0.0646 0.2976
Loa Loa (eye worm) hypothetical protein 0.0106 0.0081 0.0145
Schistosoma mansoni hypothetical protein 0.0314 0.0275 0.0494
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0015 0.0024
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0 0.00000014448
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.002 0.0036
Echinococcus granulosus caspase 0.031 0.0271 0.0487
Schistosoma mansoni Replicative DNA helicase 0.1225 0.1125 0.2022
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0022 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0017 0.0058
Plasmodium falciparum serine repeat antigen 7 0.0712 0.0646 0.2244
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0002 0.0005
Echinococcus multilocularis heat shock protein 90 0.0028 0.0008 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.1687 0.1555 0.5411
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0074 0.0256
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0022
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0 0.00000014448
Giardia lamblia Cathepsin B precursor 0.0712 0.0646 0.2976
Giardia lamblia Cathepsin B precursor 0.2342 0.2166 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0019 0.0064
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0134 0.0108 0.0373
Schistosoma mansoni DNA polymerase eta 0.004 0.002 0.0036
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0134 0.0108 0.0368
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0025 0.0044
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0002 0.0005
Plasmodium falciparum serine repeat antigen 6 0.0712 0.0646 0.2244
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0105 0.0081 0.0237
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0034 0.011
Leishmania major cathepsin L-like protease 0.3099 0.2872 0.8636
Trypanosoma cruzi metacaspase 5, putative 0.0083 0.006 0.0105
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0555 0.05 0.1734
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.9863 0.9177 0.9176
Toxoplasma gondii cathepsin CPC2 0.0766 0.0697 0.2421
Trypanosoma brucei unspecified product 0.004 0.002 0.0055
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0022
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0019 0.0032
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.002 0.0055
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0066 0.0044 0.0077
Echinococcus granulosus dna polymerase kappa 0.004 0.002 0.0036
Echinococcus multilocularis hexokinase 0.0082 0.0059 0.0106
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0019 0 0.0001
Brugia malayi cathepsin F-like cysteine proteinase 0.0712 0.0646 0.1162
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.0212 0.0205
Plasmodium vivax serine-repeat antigen (SERA) 0.0712 0.0646 0.2244
Brugia malayi Papain family cysteine protease containing protein 0.1687 0.1555 0.2796
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0057 0.0036 0.0062
Onchocerca volvulus 0.0082 0.0059 0.0206
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0012 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0012 0.0022
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1687 0.1555 0.2796
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.0082 0.0148
Brugia malayi Isocitrate dehydrogenase 0.0066 0.0044 0.0079
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.006 0.0205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0012 0.0022
Schistosoma mansoni topbp1 0.0021 0.0002 0.0003
Trypanosoma cruzi cysteine peptidase, putative 0.3585 0.3324 0.5977
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0766 0.0697 0.321
Mycobacterium leprae Probable lipase LipE 0.0039 0.0018 0.0049
Toxoplasma gondii ABC1 family protein 0.0039 0.0018 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0028 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0069 0.0124
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0029 0.0243
Loa Loa (eye worm) hexokinase 0.0025 0.0006 0.0011
Echinococcus granulosus survival motor neuron protein 1 0.0252 0.0217 0.039
Echinococcus multilocularis dna polymerase kappa 0.004 0.002 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.3099 0.2872 1
Giardia lamblia Cysteine protease 0.0712 0.0646 0.2976
Echinococcus multilocularis muscleblind protein 1 0.0474 0.0424 0.0762
Entamoeba histolytica cysteine protease, putative 0.0712 0.0646 0.2244
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0018 0.0033
Echinococcus multilocularis expressed conserved protein 0.042 0.0374 0.0673
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0074 0.0256
Schistosoma mansoni cathepsin S (C01 family) 0.0712 0.0646 0.1162
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.003 0.0054
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0003
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0043 0.0076
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0712 0.0646 0.1162
Echinococcus multilocularis Smad4 0.0043 0.0022 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.3099 0.2872 1
Onchocerca volvulus 0.3099 0.2872 1
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0067 0.0045 0.008
Brugia malayi Cathepsin L-like precursor 0.3099 0.2872 0.5164
Brugia malayi ecdysteroid receptor 0.0032 0.0012 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.3099 0.2872 1
Entamoeba histolytica cysteine proteinase, putative 0.1687 0.1555 0.5411
Echinococcus multilocularis cysteine protease 0.3099 0.2872 0.5164
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0766 0.0697 0.321
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0018 0.0146
Plasmodium falciparum cysteine proteinase falcipain 1 0.1687 0.1555 0.5411
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0066 0.0044 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2125 0.1963 0.6835
Trichomonas vaginalis cdc25b, putative 0.0227 0.0194 0.0672
Toxoplasma gondii preprocathepsin c precursor, putative 0.0855 0.078 0.271
Loa Loa (eye worm) isocitrate dehydrogenase 0.0066 0.0044 0.0079
Onchocerca volvulus 0.0039 0.0018 0.0064
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0712 0.0646 0.1162
Onchocerca volvulus 0.0044 0.0023 0.0081
Loa Loa (eye worm) hypothetical protein 0.0038 0.0017 0.0031
Onchocerca volvulus 0.3099 0.2872 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.3099 0.2872 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3585 0.3324 1
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0134 0.0108 0.0368
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0019 0.0051
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0043 0.0076
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Echinococcus multilocularis caspase 2 0.018 0.0151 0.0271
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.0081 0.0275
Loa Loa (eye worm) hypothetical protein 0.0113 0.0088 0.0158
Leishmania major DNA polymerase kappa, putative 0.004 0.002 0.0036
Onchocerca volvulus 0.005 0.0029 0.0102
Entamoeba histolytica cysteine proteinase, putative 0.1687 0.1555 0.5411
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0022
Giardia lamblia DINP protein human, muc B family 0.004 0.002 0.0084
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0002 0.00000018824
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.006 0.0205
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0102 0.0077 0.0138
Brugia malayi hypothetical protein 0.0074 0.0052 0.0093
Brugia malayi beta-lactamase family protein 0.0039 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.006 0.0039 0.0069
Loa Loa (eye worm) nuclear factor I 0.0024 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.005 0.0029 0.0052
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.002 0.0034
Mycobacterium ulcerans hypothetical protein 0.0039 0.0018 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.002 0.0055
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.0015 0.0024
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0018 0.0011
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0012 0.0022
Leishmania major mitochondrial DNA polymerase beta 0.0321 0.0282 0.0826
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0134 0.0108 0.0191
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.005 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0712 0.0646 0.2248
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0712 0.0646 0.1162
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0712 0.0646 0.2244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0712 0.0646 0.1162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0927 0.0846 0.2945
Loa Loa (eye worm) hypothetical protein 0.0209 0.0177 0.0319
Loa Loa (eye worm) inositol-1 0.0039 0.0019 0.0034
Entamoeba histolytica rodhanase-like domain containing protein 0.0227 0.0194 0.0668
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.031 0.0271 0.0487
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0134 0.0108 0.0373
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.0017 0.0137
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.0074 0.0133
Schistosoma mansoni hypothetical protein 0.0041 0.0021 0.0037
Entamoeba histolytica cysteine protease, putative 0.1687 0.1555 0.5411
Entamoeba histolytica cysteine protease, putative 0.1687 0.1555 0.5411
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0134 0.0108 0.0193
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.169 0.1558 0.2802
Brugia malayi Papain family cysteine protease containing protein 0.1687 0.1555 0.2796
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0034 0.0058
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.0015 0.0058
Echinococcus granulosus nibrin 0.0021 0.0002 0.0003
Brugia malayi Smad1 0.0043 0.0022 0.004
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0134 0.0108 0.0193
Mycobacterium ulcerans molybdopterin biosynthesis-like protein MoeZ 0.0027 0.0008 0.005
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0039 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0012 0.0022
Echinococcus granulosus muscleblind protein 0.0474 0.0424 0.0762
Loa Loa (eye worm) hypothetical protein 0.005 0.0029 0.0052
Schistosoma mansoni patched 1 0.0045 0.0025 0.0044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2342 0.2166 0.3895
Loa Loa (eye worm) hypothetical protein 0.0092 0.0068 0.0122
Brugia malayi Cathepsin L-like precursor 0.3099 0.2872 0.5164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2125 0.1963 0.6835
Brugia malayi Papain family cysteine protease containing protein 0.0712 0.0646 0.1162
Loa Loa (eye worm) hypothetical protein 0.3099 0.2872 0.5164
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0178 0.0149 0.0511
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0 0.00000014448
Brugia malayi CHE-14 protein 0.0045 0.0025 0.0044
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0022 0.004
Echinococcus granulosus neuropeptide s receptor 0.0496 0.0445 0.08
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0342 0.0301 0.0894
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0227 0.0194 0.0672
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0018 0.0033
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.0027 0.0008 0.0013
Schistosoma mansoni endoplasmin 0.0035 0.0015 0.0026
Treponema pallidum fructose-bisphosphate aldolase 0.0927 0.0846 0.7521
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1687 0.1555 0.2796
Trypanosoma brucei hexokinase 0.0082 0.0059 0.0172
Echinococcus granulosus microtubule associated protein 2 0.074 0.0672 0.1209
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0015 0.0044
Echinococcus granulosus chromobox protein 1 0.0072 0.005 0.0089
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0124 0.035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0016 0.0008
Schistosoma mansoni hexokinase 0.0082 0.0059 0.0106
Brugia malayi chromobox protein homolog 3 0.004 0.002 0.0036
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0027 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0017 0.0058
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0027 0.0049
Onchocerca volvulus Cathepsin F homolog 0.3099 0.2872 1
Loa Loa (eye worm) hypothetical protein 0.0262 0.0226 0.0407
Echinococcus granulosus heat shock protein 90 0.0028 0.0008 0.0014
Giardia lamblia Cathepsin L-like protease 0.0712 0.0646 0.2976
Plasmodium falciparum heat shock protein 90 0.0035 0.0015 0.0044
Trypanosoma cruzi FHA domain containing protein, putative 0.0021 0.0002 0.0001
Trypanosoma brucei unspecified product 0.0028 0.0008 0.0019
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.003 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0027 0.0049
Schistosoma mansoni Smad4 0.0043 0.0022 0.004
Trypanosoma brucei protein kinase, putative 0.0055 0.0034 0.0095
Onchocerca volvulus 0.0227 0.0194 0.0675
Brugia malayi cathepsin B-like cysteine proteinase 0.5984 0.556 1
Brugia malayi MH2 domain containing protein 0.0043 0.0022 0.004
Echinococcus multilocularis protein patched 0.0045 0.0025 0.0044
Schistosoma mansoni chromobox protein 0.0072 0.005 0.0089
Brugia malayi Cathepsin L-like precursor 0.2125 0.1963 0.353
Entamoeba histolytica cysteine protease, putative 0.1687 0.1555 0.5411
Onchocerca volvulus 0.0051 0.003 0.0105
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0134 0.0108 0.0368
Schistosoma mansoni cathepsin s 0.0975 0.0891 0.1602
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.003 0.0054
Brugia malayi Cathepsin L-like precursor 0.3099 0.2872 0.5164
Loa Loa (eye worm) TAR-binding protein 0.0134 0.0108 0.0193
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.0074 0.02
Onchocerca volvulus Cathepsin L homolog 0.0712 0.0646 0.2249
Echinococcus multilocularis cathepsin l cysteine peptidase 0.3099 0.2872 0.5164
Entamoeba histolytica cysteine proteinase 1, putative 0.1687 0.1555 0.5411
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0017 0.0054
Trypanosoma cruzi metacaspase, putative 0.0083 0.006 0.0105
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0083 0.006 0.0201
Loa Loa (eye worm) hypothetical protein 0.0058 0.0037 0.0066
Loa Loa (eye worm) hypothetical protein 0.0134 0.0108 0.0193
Leishmania major ubiquitin-activating enzyme-like protein 0.0067 0.0045 0.011
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0134 0.0108 0.0373
Plasmodium falciparum metacaspase 1 0.0083 0.006 0.0201
Trypanosoma cruzi metacaspase, putative 0.0083 0.006 0.0105
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0555 0.05 0.0898
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0066 0.0044 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.002 0.0055
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0134 0.0108 0.0368
Loa Loa (eye worm) hypothetical protein 0.0134 0.0108 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0712 0.0646 0.2248
Brugia malayi Muscleblind-like protein 0.0474 0.0424 0.0762
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.014 0.0133
Brugia malayi Pre-SET motif family protein 0.0213 0.0181 0.0324
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.002 0.0055
Echinococcus granulosus tar DNA binding protein 0.0134 0.0108 0.0193
Loa Loa (eye worm) hypothetical protein 0.0051 0.003 0.0054
Onchocerca volvulus 0.3099 0.2872 1
Mycobacterium ulcerans recombinase A 0.0342 0.0301 0.2666
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.0069 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0012 0.0022
Brugia malayi mbt repeat family protein 0.0051 0.003 0.0054
Trypanosoma brucei hexokinase, putative 0.0082 0.0059 0.0172
Trypanosoma cruzi metacaspase, putative 0.0083 0.006 0.0105
Giardia lamblia Fructose-bisphosphate aldolase 0.0927 0.0846 0.3902
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0017 0.0053
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0083 0.006 0.0107
Echinococcus granulosus apoptotic protease activating factor 1 0.0098 0.0074 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0074 0.0256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3585 0.3324 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0453 0.0404 0.1202
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0067 0.0045 0.008
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.002 0.0034
Echinococcus granulosus smad 0.0043 0.0022 0.004
Echinococcus granulosus geminin 0.0713 0.0647 0.1163
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.1225 0.1125 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0074 0.0131
Echinococcus granulosus sentrin specific protease 1 0.0134 0.0108 0.0193
Brugia malayi beta-lactamase 0.0039 0.0018 0.0033
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.003 0.0054
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0102 0.0077 0.0261
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0034 0.0058
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.0081 0.0145
Entamoeba histolytica cysteine protease, putative 0.1687 0.1555 0.5411
Entamoeba histolytica cysteine proteinase, putative 0.3099 0.2872 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0012 0.0022
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.006 0.0205
Brugia malayi MAP kinase sur-1 0.0055 0.0034 0.006
Trypanosoma cruzi major cysteine proteinase, putative 0.0712 0.0646 0.1159
Loa Loa (eye worm) hypothetical protein 0.0102 0.0077 0.0138
Schistosoma mansoni caspase-3 (C14 family) 0.031 0.0271 0.0487
Loa Loa (eye worm) hypothetical protein 0.0134 0.0108 0.0193
Loa Loa (eye worm) hypothetical protein 0.5984 0.556 1
Echinococcus multilocularis smad 0.0043 0.0022 0.004
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0022 0.004
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.002 0.0055
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0012 0.0022
Onchocerca volvulus 0.3099 0.2872 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0712 0.0646 0.2248
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.0074 0.0252
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0 0.00000014448
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0037 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.3099 0.2872 1
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.003 0.0054
Echinococcus multilocularis microtubule associated protein 2 0.074 0.0672 0.1209
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.00000014448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3585 0.3324 1
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0018 0.0057
Plasmodium vivax vivapain-3 0.1687 0.1555 0.5411
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0034 0.0077
Giardia lamblia Grp94/Hsp90 0.0028 0.0008 0.0028
Plasmodium vivax sentrin-specific protease 1, putative 0.0134 0.0108 0.0368
Echinococcus multilocularis dna polymerase eta 0.004 0.002 0.0036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0022
Echinococcus granulosus cathepsin l cysteine peptidase 0.3099 0.2872 0.5164
Echinococcus multilocularis cathepsin L 0.0712 0.0646 0.1162
Loa Loa (eye worm) hypothetical protein 0.0092 0.0068 0.0122
Echinococcus multilocularis cathepsin L cysteine protease 0.3099 0.2872 0.5164
Loa Loa (eye worm) hypothetical protein 0.0039 0.0018 0.0033
Toxoplasma gondii cathepsin CPC1 0.0855 0.078 0.271
Entamoeba histolytica hypothetical protein 0.0074 0.0052 0.0173
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0855 0.078 0.271
Echinococcus multilocularis cathepsin b 0.5984 0.556 1
Loa Loa (eye worm) ctsf protein 0.3099 0.2872 0.5164
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0029 0.0243
Toxoplasma gondii cathepsin CPL 0.3099 0.2872 1
Schistosoma mansoni smad 0.0019 0 0.00000014448
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0012 0.0022
Brugia malayi MH1 domain containing protein 0.0043 0.0022 0.004
Brugia malayi hypothetical protein 0.0021 0.0002 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.3099 0.2872 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0037 0.0066
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0021 0.0037
Onchocerca volvulus Huntingtin homolog 0.0262 0.0226 0.0789
Loa Loa (eye worm) heat shock protein 90 0.0035 0.0015 0.0026
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0134 0.0108 0.03
Brugia malayi jmjC domain containing protein 0.0065 0.0043 0.0076
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0067 0.0045 0.0078
Schistosoma mansoni survival motor neuron protein 0.0051 0.003 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0012 0.0022
Giardia lamblia Encystation-specific protease 0.0766 0.0697 0.321
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Brugia malayi MH2 domain containing protein 0.0019 0 0.00000014448
Loa Loa (eye worm) hypothetical protein 0.2125 0.1963 0.353
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0301 0.0263 0.0473
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.003 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3585 0.3324 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0022 0.004
Entamoeba histolytica heat shock transcription factor, putative 0.0106 0.0081 0.0275
Brugia malayi AMP-binding enzyme family protein 0.005 0.0029 0.0052
Trypanosoma brucei heat shock protein, putative 0.0035 0.0015 0.0038
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0012 0.0022
Onchocerca volvulus Cathepsin L homolog 0.3099 0.2872 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.0108 0.0193
Echinococcus granulosus traf and tnf receptor associated protein 0.0184 0.0154 0.0276
Schistosoma mansoni cathepsin C 0.0712 0.0646 0.1162
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0008 0.0026
Loa Loa (eye worm) hypothetical protein 0.0083 0.006 0.0107
Toxoplasma gondii hexokinase 0.0082 0.0059 0.0199
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0012 0.0022
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0083 0.006 0.0201
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0028 0.0008 0.0054
Echinococcus multilocularis nibrin 0.0021 0.0002 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0108 0.0193
Entamoeba histolytica cysteine protease, putative 0.1687 0.1555 0.5411
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.003 0.0105
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0012 0.0022
Entamoeba histolytica cysteine protease, putative 0.0712 0.0646 0.2244
Entamoeba histolytica protein kinase, putative 0.0093 0.0069 0.0234
Giardia lamblia Hypothetical protein 0.0712 0.0646 0.2976
Trypanosoma brucei Heat shock protein 83, putative 0.0035 0.0015 0.0038
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0034 0.006
Onchocerca volvulus 0.2125 0.1963 0.6836
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0012 0.0022
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.002 0.0036
Echinococcus multilocularis Niemann Pick C1 protein 0.0151 0.0123 0.0221
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0025 0.0042
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0012 0.0022
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0029 0.0243
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0012 0.0022
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0927 0.0846 0.2942
Echinococcus granulosus cysteine protease 0.1687 0.1555 0.2796
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0012 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0108 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0012 0.0022
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0018 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.004 0.002 0.0067
Loa Loa (eye worm) Ulp1 protease 0.0301 0.0263 0.0473
Toxoplasma gondii hypothetical protein 0.0102 0.0077 0.0261
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.0074 0.0133
Loa Loa (eye worm) hypothetical protein 0.0209 0.0177 0.0319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0012 0.0022
Brugia malayi Cathepsin L-like cysteine proteinase 0.2125 0.1963 0.353
Entamoeba histolytica hypothetical protein 0.0093 0.0069 0.0234
Giardia lamblia Cathepsin B precursor 0.0712 0.0646 0.2976
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0227 0.0194 0.0348
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.3099 0.2872 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.035 0.0308 0.0554
Plasmodium falciparum serine repeat antigen 9 0.0712 0.0646 0.2244
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0012 0.0022
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0034 0.0146
Loa Loa (eye worm) hypothetical protein 0.0026 0.0007 0.0012
Leishmania major cathepsin L-like protease 0.3099 0.2872 0.8636
Giardia lamblia Kinase, PLK 0.0099 0.0074 0.0334
Loa Loa (eye worm) hypothetical protein 0.0038 0.0017 0.0031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0044 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0008 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0002 0.0005
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0044 0.0126
Leishmania major basic transcription factor 3a, putative 0.0037 0.0017 0.0028
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0019 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.3099 0.2872 1
Brugia malayi hypothetical protein 0.0021 0.0002 0.0003
Brugia malayi jmjC domain containing protein 0.0063 0.0041 0.0073
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0019 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1687 0.1555 0.5413
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0027 0.0049
Loa Loa (eye worm) twinkle helicase 0.035 0.0309 0.0555
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0083 0.006 0.0201
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0015 0.0038
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0134 0.0108 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0002 0.0005
Onchocerca volvulus 0.0103 0.0078 0.0272
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.002 0.0036
Echinococcus multilocularis transcription factor eb 0.0114 0.0089 0.0159
Giardia lamblia Cathepsin B precursor 0.2342 0.2166 1
Trypanosoma cruzi cysteine peptidase, putative 0.3099 0.2872 0.5163
Trypanosoma cruzi Heat shock protein 83, putative 0.0035 0.0015 0.0024
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0032 0.0012 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.3099 0.2872 1
Plasmodium vivax sentrin-specific protease 2, putative 0.0134 0.0108 0.0368
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0027 0.0049
Echinococcus granulosus dna polymerase eta 0.004 0.002 0.0036
Plasmodium falciparum metacaspase-like protein 0.0083 0.006 0.0201
Echinococcus granulosus cathepsin l1 0.3099 0.2872 0.5164
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0044 0.0108
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0113 0.0088 0.0158
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.001 0.0017
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0022 0.004
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0301 0.0263 0.0914
Trypanosoma cruzi ubiquitin-activating enzyme-like protein 0.0032 0.0012 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0034 0.0115
Brugia malayi DKFZp564C0469 protein 0.0021 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0103 0.0078 0.014
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0712 0.0646 0.1162
Brugia malayi Hexokinase family protein 0.0025 0.0006 0.0011
Brugia malayi topoisomerase 0.0021 0.0002 0.0003
Plasmodium vivax endoplasmin, putative 0.0035 0.0015 0.0044
Echinococcus granulosus hexokinase type 2 0.0082 0.0059 0.0106
Brugia malayi MH1 domain containing protein 0.0024 0.0004 0.0008
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.003 0.0054
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.035 0.0308 0.0554
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0034 0.006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.5984 0.556 1
Onchocerca volvulus 0.0082 0.0059 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0108 0.0193
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0712 0.0646 0.2244
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0074 0.0256
Brugia malayi MH1 domain containing protein 0.0043 0.0022 0.004
Plasmodium falciparum serine repeat antigen 8 0.0712 0.0646 0.2244
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0052 0.0093
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.005 0.0029 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0712 0.0646 0.2248
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0046 0.0153
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0008
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.002 0.0063
Toxoplasma gondii heat shock protein 90, putative 0.0035 0.0015 0.0044
Brugia malayi hexokinase 0.0082 0.0059 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.002 0.0055
Loa Loa (eye worm) hypothetical protein 0.0975 0.0891 0.1602
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0134 0.0108 0.0373
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.0053 0.0095
Brugia malayi Hexokinase family protein 0.0052 0.0031 0.0055
Giardia lamblia Ubiquitin-activating enzyme E1 1 0.0032 0.0012 0.0046
Echinococcus granulosus cpg binding protein 0.0037 0.0017 0.003
Giardia lamblia Cathepsin L precursor 0.0712 0.0646 0.2976
Onchocerca volvulus 0.0039 0.0018 0.0064
Treponema pallidum heat shock protein 90 0.0028 0.0008 0.0054
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0018 0.0062
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0034 0.006
Giardia lamblia Cathepsin B precursor 0.2342 0.2166 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0025 0.0042
Echinococcus multilocularis muscleblind protein 0.0474 0.0424 0.0762
Schistosoma mansoni DNA ligase IV 0.0021 0.0002 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0034 0.0115
Schistosoma mansoni hypothetical protein 0.0098 0.0074 0.0132
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0204 0.0173 0.031
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0134 0.0108 0.0941
Onchocerca volvulus 0.0227 0.0194 0.0675
Echinococcus granulosus caspase 2 0.018 0.0151 0.0271
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0 0.00000014448
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0712 0.0646 0.1162
Brugia malayi Protein-tyrosine phosphatase containing protein 0.035 0.0308 0.0554
Entamoeba histolytica cysteine proteinase 2 0.1687 0.1555 0.5411
Treponema pallidum recombinase A 0.0342 0.0301 0.2666
Plasmodium vivax vivapain-2 0.3099 0.2872 1
Trypanosoma brucei Metacaspase-4 0.0083 0.006 0.0173
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Echinococcus multilocularis transcription factor btf3 0.0037 0.0017 0.0031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0012 0.0022
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0008 0.0012
Leishmania major cathepsin L-like protease 0.3585 0.3324 1
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0017 0.0031
Echinococcus granulosus endoplasmin 0.0028 0.0008 0.0014
Entamoeba histolytica cysteine protease, putative 0.1687 0.1555 0.5411
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0018 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0012 0.0022
Brugia malayi Endoplasmin precursor 0.0035 0.0015 0.0026
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0067 0.0045 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0867 0.0791 0.2751
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0002 0.0001
Mycobacterium ulcerans heat shock protein 90 0.0028 0.0008 0.0054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0012 0.0022
Schistosoma mansoni coup transcription factor 0.0032 0.0012 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.002 0.0055
Plasmodium falciparum sentrin-specific protease 1 0.0134 0.0108 0.0368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3585 0.3324 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.2342 0.2166 0.7542
Brugia malayi Cathepsin L-like precursor 0.0975 0.0891 0.1602
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0712 0.0646 0.2244
Entamoeba histolytica hypothetical protein 0.0074 0.0052 0.0173
Leishmania major cathepsin L-like protease 0.3099 0.2872 0.8636
Entamoeba histolytica protein kinase, putative 0.0093 0.0069 0.0234
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.5984 0.556 1
Echinococcus granulosus expressed conserved protein 0.0099 0.0075 0.0134
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0012 0.0022
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0043 0.0076
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0044 0.0077
Trypanosoma brucei unspecified product 0.0028 0.0008 0.0019
Schistosoma mansoni smad1 5 8 and 0.0043 0.0022 0.004
Loa Loa (eye worm) hypothetical protein 0.0227 0.0194 0.0348
Echinococcus multilocularis hexokinase 0.0082 0.0059 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0712 0.0646 0.2248
Schistosoma mansoni smad1 5 8 and 0.0043 0.0022 0.004
Loa Loa (eye worm) hypothetical protein 0.0712 0.0646 0.1162
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0067 0.0045 0.0128
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.3099 0.2872 0.5164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.3099 0.2872 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0975 0.0891 0.1602
Schistosoma mansoni kinase 0.0051 0.003 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0712 0.0646 0.2248
Entamoeba histolytica cysteine proteinase, putative 0.1687 0.1555 0.5411
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0012 0.0022
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0012 0.0022
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0184 0.0154 0.0276
Schistosoma mansoni Smad4 0.0019 0 0.00000014448
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0029 0.0081
Loa Loa (eye worm) cysteine protease 0.3099 0.2872 0.5164
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.002 0.0055
Brugia malayi Hexokinase family protein 0.0082 0.0059 0.0106
Mycobacterium tuberculosis Conserved protein 0.0039 0.0018 0.0011
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0052 0.0093
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.002 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.002 0.0034
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0019 0.0059
Echinococcus multilocularis sentrin specific protease 8 0.0301 0.0263 0.0473
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Plasmodium falciparum cysteine proteinase falcipain 2b 0.3099 0.2872 1
Entamoeba histolytica cysteine proteinase, putative 0.2125 0.1963 0.6833
Mycobacterium ulcerans DNA polymerase IV 0.004 0.002 0.0162
Brugia malayi cathepsin Z-like cysteine proteinase 0.0867 0.0791 0.1421
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.002 0.0036
Echinococcus multilocularis isocitrate dehydrogenase 0.0066 0.0044 0.0079
Brugia malayi hypothetical protein 0.0252 0.0217 0.039
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0012 0.0022
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0017 0.0137
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0025 0.0044
Plasmodium falciparum endoplasmin, putative 0.0021 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.2125 0.1963 0.353
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.002 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0927 0.0846 0.2945
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0002 0.0001
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0321 0.0282 0.0843
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Onchocerca volvulus 0.0134 0.0108 0.0375
Loa Loa (eye worm) hypothetical protein 0.0474 0.0424 0.0762
Echinococcus multilocularis caspase 0.031 0.0271 0.0487
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0927 0.0846 0.2942
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0801 0.0729 0.2536
Brugia malayi cathepsin L-like precursor 0.2125 0.1963 0.353
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0012 0.0022
Schistosoma mansoni cpg binding protein 0.0037 0.0017 0.003
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0044 0.0146
Entamoeba histolytica cysteine proteinase, putative 0.3099 0.2872 1
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.002 0.0055
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.002 0.0013
Giardia lamblia Cysteine protease 0.0712 0.0646 0.2976
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0012 0.0022
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0044 0.0146
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0204 0.0173 0.031
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0002 0.0005
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0012 0.0043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0017 0.0031
Schistosoma mansoni hypothetical protein 0.0713 0.0647 0.1163
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.5984 0.556 1
Mycobacterium ulcerans hypothetical protein 0.005 0.0029 0.0243
Trypanosoma cruzi cysteine proteinase, putative 0.1687 0.1555 0.2794
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0002 0.0003
Brugia malayi hexokinase type II 0.0026 0.0007 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.3099 0.2872 1
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0301 0.0263 0.0473
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1687 0.1555 0.2796
Loa Loa (eye worm) hexokinase 0.0082 0.0059 0.0106
Loa Loa (eye worm) cathepsin B 0.2342 0.2166 0.3895
Giardia lamblia Cathepsin B precursor 0.0712 0.0646 0.2976
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0023 0.0042
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.006 0.0205
Loa Loa (eye worm) hypothetical protein 0.0975 0.0891 0.1602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1687 0.1555 0.5413
Brugia malayi MH2 domain containing protein 0.0626 0.0566 0.1017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0039 0.0069
Mycobacterium ulcerans replicative DNA helicase DnaB 0.1225 0.1125 1
Echinococcus multilocularis endoplasmin 0.0028 0.0008 0.0014
Echinococcus multilocularis caspase 8 0.0083 0.006 0.0107
Echinococcus multilocularis tumor protein p63 0.0702 0.0636 0.1144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0712 0.0646 0.2248
Giardia lamblia Heat shock protein HSP 90-alpha 0.0028 0.0008 0.0028
Mycobacterium tuberculosis Conserved protein 0.0039 0.0018 0.0011
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0074 0.0131
Onchocerca volvulus Hexokinase homolog 0.0052 0.0031 0.0106
Trypanosoma cruzi metacaspase 5, putative 0.0083 0.006 0.0105
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.002 0.007
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0034 0.0058
Plasmodium vivax vivapain-2 0.3099 0.2872 1
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0134 0.0108 0.0191
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.031 0.0271 0.0487
Brugia malayi isocitrate dehydrogenase 0.0066 0.0044 0.0079
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0013
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0018 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.002 0.0055
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0041 0.0073
Brugia malayi fibroinase precursor 0.0712 0.0646 0.1162
Echinococcus multilocularis survival motor neuron protein 1 0.0252 0.0217 0.039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0016 0.0008
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.006 0.0205
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0017 0.0029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0027 0.0049
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.0282 0.0505
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0712 0.0646 0.2244
Plasmodium falciparum serine repeat antigen 5 0.0712 0.0646 0.2244
Loa Loa (eye worm) hypothetical protein 0.0712 0.0646 0.1162
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.006 0.0205
Loa Loa (eye worm) hexokinase 0.0082 0.0059 0.0106
Brugia malayi hypothetical protein 0.0262 0.0226 0.0407
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.5984 0.556 1
Echinococcus granulosus tumor protein p63 0.0702 0.0636 0.1144
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0034 0.006
Echinococcus granulosus cathepsin L cysteine protease 0.1687 0.1555 0.2796
Giardia lamblia Hypothetical protein 0.0712 0.0646 0.2976
Leishmania major hypothetical protein, conserved 0.0039 0.0018 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3585 0.3324 1
Schistosoma mansoni smad1 5 8 and 0.0043 0.0022 0.004
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.0008 0.0018
Brugia malayi mbt repeat family protein 0.0051 0.003 0.0054
Treponema pallidum replicative DNA helicase (dnaB) 0.1225 0.1125 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0855 0.078 0.271
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0181 0.0151 0.0271
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0022
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0019 0.0152
Entamoeba histolytica cysteine protease, putative 0.0712 0.0646 0.2244
Trypanosoma brucei cysteine peptidase C (CPC) 0.2342 0.2166 0.6513
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0022 0.004
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.2342 0.2166 0.6507
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0018 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0012 0.0022
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0008 0.0026
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0134 0.0108 0.0941
Plasmodium vivax serine-repeat antigen (SERA) 0.0712 0.0646 0.2244
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0012 0.0043
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0067 0.0045 0.008
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0066 0.0044 0.0079
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.003 0.0054
Toxoplasma gondii heat shock protein HSP90 0.0035 0.0015 0.0044
Echinococcus multilocularis heat shock protein 0.0035 0.0015 0.0026
Echinococcus granulosus dual specificity 0.0093 0.0069 0.0124
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.0443 0.0796
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0018 0.0033
Plasmodium vivax unspecified product 0.0712 0.0646 0.2244
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0012 0.0022
Giardia lamblia Cathepsin L precursor 0.0712 0.0646 0.2976
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.5984 0.556 1
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.0081 0.0145
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.006 0.0205
Echinococcus multilocularis chromobox protein 1 0.0072 0.005 0.0089
Onchocerca volvulus 0.0227 0.0194 0.0675
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0002 0.0005
Echinococcus multilocularis cathepsin L 0.1687 0.1555 0.2796
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.0074 0.0259
Plasmodium falciparum serine repeat antigen 1 0.0712 0.0646 0.2244
Echinococcus granulosus cathepsin L 0.1687 0.1555 0.2796
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.002 0.0034
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0032 0.0012 0.0035
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0134 0.0108 0.0373
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0052 0.0093
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0015 0.0026
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0037
Echinococcus granulosus neuropeptide receptor A26 0.0496 0.0445 0.08
Loa Loa (eye worm) ThiF family protein 0.0067 0.0045 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3585 0.3324 1
Trypanosoma brucei metacaspase 5, putative 0.0083 0.006 0.0173
Loa Loa (eye worm) hypothetical protein 0.2125 0.1963 0.353
Echinococcus granulosus chromobox protein 1 0.0072 0.005 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0025 0.0083
Loa Loa (eye worm) hypothetical protein 0.0038 0.0017 0.0031
Echinococcus multilocularis neuropeptide s receptor 0.0496 0.0445 0.08
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0134 0.0108 0.0373
Loa Loa (eye worm) endoplasmin 0.0035 0.0015 0.0026
Brugia malayi MH2 domain containing protein 0.0043 0.0022 0.004
Brugia malayi beta-lactamase family protein 0.0039 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0022
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0025 0.0044
Echinococcus granulosus cathepsin l1 0.2125 0.1963 0.353
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0025 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0108 0.0193
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0002 0.0005
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.0081 0.0145
Plasmodium vivax heat shock protein 86, putative 0.0035 0.0015 0.0044
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0018 0.0011
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0855 0.078 0.1402
Echinococcus multilocularis expressed conserved protein 0.0099 0.0075 0.0134
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0028 0.0096
Leishmania major cathepsin L-like protease 0.3099 0.2872 0.8636
Loa Loa (eye worm) hypothetical protein 0.0975 0.0891 0.1602
Trypanosoma cruzi hexokinase, putative 0.0082 0.0059 0.0104
Loa Loa (eye worm) hypothetical protein 0.0056 0.0034 0.0061
Onchocerca volvulus 0.3099 0.2872 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.002 0.0036
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0092 0.0068 0.0123
Schistosoma mansoni Smad4 0.0019 0 0.00000014448
Schistosoma mansoni cathepsin B (C01 family) 0.0712 0.0646 0.1162
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0766 0.0697 0.2421
Trichomonas vaginalis chromobox protein, putative 0.0072 0.005 0.017
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0017 0.0053
Echinococcus granulosus transcription factor btf3 0.0037 0.0017 0.0031
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0067 0.0045 0.0149
Echinococcus multilocularis heat shock protein 90 0.0035 0.0015 0.0026
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.0282 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.006 0.0205
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0018 0.0011
Entamoeba histolytica heat shock transcription factor, putative 0.0106 0.0081 0.0275
Onchocerca volvulus Cell death protein 3 homolog 0.018 0.0151 0.0525
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0015 0.0044
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0015 0.0038
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0034 0.0095
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0029 0.0095
Plasmodium falciparum cysteine proteinase falcipain 2a 0.3099 0.2872 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.0008 0.0014
Plasmodium falciparum hexokinase 0.0082 0.0059 0.0199
Plasmodium vivax metacaspase 1, putative 0.0083 0.006 0.0201
Brugia malayi Protein kinase domain containing protein 0.0093 0.0069 0.0124
Echinococcus multilocularis neuropeptide receptor A26 0.0496 0.0445 0.08
Loa Loa (eye worm) MH2 domain-containing protein 0.0626 0.0566 0.1017
Treponema pallidum hexokinase (hxk) 0.0082 0.0059 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0012 0.0022
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.0181 0.0324
Brugia malayi Pre-SET motif family protein 0.0032 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0474 0.0424 0.0762
Echinococcus multilocularis caspase 3 0.0227 0.0194 0.0348
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.002 0.0036
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0134 0.0108 0.0368
Giardia lamblia Cysteine protease 0.0712 0.0646 0.2976
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0017 0.0029
Brugia malayi Rhodanese-like domain containing protein 0.0227 0.0194 0.0348
Brugia malayi Papain family cysteine protease containing protein 0.3099 0.2872 0.5164
Entamoeba histolytica hypothetical protein 0.0712 0.0646 0.2244
Onchocerca volvulus 0.0051 0.003 0.0105
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0016 0.0008
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0712 0.0646 0.2244
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0029 0.0243
Trypanosoma brucei heat shock protein, putative 0.0035 0.0015 0.0038
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0093 0.0069 0.0202
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0044 0.0079
Loa Loa (eye worm) hexokinase type II 0.0082 0.0059 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.002 0.0055
Loa Loa (eye worm) hypothetical protein 0.0039 0.0018 0.0033
Toxoplasma gondii cathepsin B 0.2342 0.2166 0.754
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0012 0.0022
Brugia malayi Papain family cysteine protease containing protein 0.0712 0.0646 0.1162
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0012 0.0022
Loa Loa (eye worm) MBCTL1 0.0058 0.0037 0.0066
Brugia malayi AMP-binding enzyme family protein 0.005 0.0029 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0927 0.0846 0.2945
Trichomonas vaginalis cdc25c, putative 0.0227 0.0194 0.0672
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0034 0.0115
Toxoplasma gondii ThiF family protein 0.0067 0.0045 0.0149
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0012 0.0022
Mycobacterium leprae PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE) 0.0027 0.0008 0.0017
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0975 0.0891 0.1602
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.002 0.0034
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0102 0.0077 0.0138
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0034 0.0115
Loa Loa (eye worm) hypothetical protein 0.0712 0.0646 0.1162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1687 0.1555 0.4674
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0012 0.0022
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0012 0.0022
Schistosoma mansoni microtubule-associated protein tau 0.074 0.0672 0.1209
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0041 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0712 0.0646 0.2248
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0134 0.0108 0.0193
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0855 0.078 0.271
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0712 0.0646 0.1162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3585 0.3324 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0019 0.0064
Leishmania major hexokinase, putative 0.0082 0.0059 0.0154
Echinococcus granulosus Smad4 0.0043 0.0022 0.004
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0034 0.0058
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0712 0.0646 0.1162
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0012 0.0022
Echinococcus multilocularis cathepsin b 0.5984 0.556 1
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0018 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.3099 0.2872 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0093 0.0069 0.0124
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0066 0.0044 0.0146
Leishmania major heat shock protein 83-1 0.0035 0.0015 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0074 0.0256
Loa Loa (eye worm) protein-tyrosine phosphatase 0.035 0.0308 0.0554
Trypanosoma brucei metacaspase MCA3 0.0083 0.006 0.0173
Trypanosoma cruzi hypothetical protein 0.0301 0.0263 0.0471
Trypanosoma brucei polo-like protein kinase 0.0099 0.0074 0.0218
Plasmodium vivax vivapain-1 0.1687 0.1555 0.5411
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0037 0.0066
Trichomonas vaginalis Sentrin-specific protease, putative 0.0301 0.0263 0.0914
Leishmania major hexokinase, putative 0.0082 0.0059 0.0154
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0074 0.0256
Entamoeba histolytica cysteine protease, putative 0.0712 0.0646 0.2244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0012 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0029 0.0022
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0453 0.0404 0.3584
Entamoeba histolytica hypothetical protein 0.0074 0.0052 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0027 0.0049
Loa Loa (eye worm) hypothetical protein 0.0038 0.0017 0.0031
Schistosoma mansoni endoplasmin 0.0035 0.0015 0.0026
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0012 0.0022
Echinococcus multilocularis dual specificity 0.0093 0.0069 0.0124
Onchocerca volvulus 0.0035 0.0015 0.0051
Leishmania major cathepsin L-like protease 0.3585 0.3324 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.3099 0.2872 0.5164
Brugia malayi Cathepsin L-like precursor 0.3099 0.2872 0.5164
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0021
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0015 0.0039
Schistosoma mansoni caspase-7 (C14 family) 0.018 0.0151 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0002 0.0005
Echinococcus granulosus transcription factor eb 0.0114 0.0089 0.0159
Echinococcus granulosus cathepsin L 0.0712 0.0646 0.1162
Onchocerca volvulus 0.0052 0.0031 0.0106
Echinococcus granulosus expressed conserved protein 0.042 0.0374 0.0673
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.002 0.0068
Echinococcus granulosus Niemann Pick C1 protein 0.0151 0.0123 0.0221
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0712 0.0646 0.2976
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2342 0.2166 0.3894
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0044 0.0079
Trypanosoma brucei metacaspase 0.0083 0.006 0.0173
Trichomonas vaginalis set domain proteins, putative 0.0242 0.0208 0.0721
Trichomonas vaginalis esterase, putative 0.0039 0.0018 0.0062
Giardia lamblia Cysteine protease 0.0712 0.0646 0.2976
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0453 0.0404 0.0397
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0012 0.0022
Brugia malayi Papain family cysteine protease containing protein 0.0712 0.0646 0.1162
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0 0.00000014448
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0029 0.0064
Onchocerca volvulus 0.0032 0.0012 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0083 0.006 0.0201
Leishmania major metacaspase, putative 0.0083 0.006 0.0155
Chlamydia trachomatis recombinase RecA 0.0342 0.0301 0.2666
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.0002 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0712 0.0646 0.2248
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0012 0.0022
Loa Loa (eye worm) Ulp1 protease 0.0134 0.0108 0.0193
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0037 0.0017 0.003
Trypanosoma brucei heat shock protein, putative 0.0035 0.0015 0.0038
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0022
Brugia malayi RNA binding protein 0.0134 0.0108 0.0193
Entamoeba histolytica hexokinase 1 0.0082 0.0059 0.0199
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0029 0.0243
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0002 0.0005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0975 0.0891 0.1602
Loa Loa (eye worm) hypothetical protein 0.0026 0.0007 0.0012
Onchocerca volvulus 0.0021 0.0002 0.0007
Entamoeba histolytica cysteine protease, putative 0.1687 0.1555 0.5411
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0018 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0712 0.0646 0.2248
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0008 0.0026
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.006 0.0205
Brugia malayi Heterochromatin protein 1 0.0072 0.005 0.0089
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0012 0.0022
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0015 0.0024
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0043 0.0076
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0012 0.0022
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.0074 0.0133
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0015 0.0049
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0034 0.006
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0066 0.0044 0.0079
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0015 0.0024
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0066 0.0044 0.0146
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0712 0.0646 0.1162
Trypanosoma brucei metacaspase MCA2 0.0083 0.006 0.0173
Onchocerca volvulus 0.0712 0.0646 0.2249

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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