Detailed information for compound 1350414

Basic information

Technical information
  • TDR Targets ID: 1350414
  • Name: 2-[5-(4-methylphenyl)thieno[3,2-e]pyrimidin-4 -yl]sulfanyl-N-(5-methyl-1,3,4-thiadiazol-2-y l)acetamide
  • MW: 413.54 | Formula: C18H15N5OS3
  • H donors: 1 H acceptors: 5 LogP: 4.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1nnc(s1)C)CSc1ncnc2c1c(cs2)c1ccc(cc1)C
  • InChi: 1S/C18H15N5OS3/c1-10-3-5-12(6-4-10)13-7-25-16-15(13)17(20-9-19-16)26-8-14(24)21-18-23-22-11(2)27-18/h3-7,9H,8H2,1-2H3,(H,21,23,24)
  • InChiKey: PFTODMRMDVKTMF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5-(4-methylphenyl)-4-thieno[3,2-e]pyrimidinyl]thio]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide
  • 2-[[5-(4-methylphenyl)thieno[3,2-e]pyrimidin-4-yl]thio]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide
  • 2-[5-(4-methylphenyl)thieno[3,2-e]pyrimidin-4-yl]sulfanyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)ethanamide
  • MLS000557047
  • N-(5-Methyl-[1,3,4]thiadiazol-2-yl)-2-(5-p-tolyl-thieno[2,3-d]pyrimidin-4-ylsulfanyl)-acetamide
  • SMR000172843
  • ZINC04215411
  • ASN 04462120

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serotonin receptor 0.0257 0.0976 0.1766
Brugia malayi RE15519p 0.0257 0.0976 0.1267
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0023 0.0038
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0101 0.6215
Brugia malayi hypothetical protein 0.0045 0.0116 0.0151
Echinococcus multilocularis neuropeptide receptor 0.0257 0.0976 0.0976
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0257 0.0976 0.1766
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0023 0.0119
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0163 0.1012
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Echinococcus granulosus Smad4 0.0026 0.0039 0.007
Onchocerca volvulus 0.0257 0.0976 0.7568
Plasmodium vivax potassium channel, putative 0.0045 0.0116 0.4867
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0257 0.0976 0.1766
Onchocerca volvulus Prolyl endopeptidase homolog 0.0027 0.0041 0.0299
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0039 0.005
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0 0.0012
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0028 0.0047
Echinococcus granulosus neuropeptides capa receptor 0.0257 0.0976 0.1766
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0095 0.0123
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0039 0.007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0257 0.0976 0.0976
Plasmodium falciparum flap endonuclease 1 0.0027 0.0044 0.2675
Schistosoma mansoni alpha-1 adrenergic receptor 0.0257 0.0976 0.1766
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0257 0.0976 0.7568
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Brugia malayi beta-lactamase 0.0075 0.0239 0.031
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Trypanosoma cruzi metacaspase, putative 0.0018 0.0008 0.0014
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0083 0.0108
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0023 0.0035
Trypanosoma brucei metacaspase 5, putative 0.0018 0.0008 0.0014
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0114 0.0394 0.1766
Echinococcus granulosus rhodopsin orphan GPCR 0.0257 0.0976 0.1766
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0257 0.0976 0.1267
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0058 0.0104
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0017 0.0003 0.0003
Onchocerca volvulus Putative nachr subunit 0.0037 0.0083 0.0626
Loa Loa (eye worm) hypothetical protein 0.0877 0.3482 0.452
Echinococcus multilocularis G protein coupled receptor 139 0.0257 0.0976 0.0976
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0626 0.2829
Loa Loa (eye worm) hypothetical protein 0.0154 0.0558 0.0724
Brugia malayi hypothetical protein 0.0257 0.0976 0.1267
Schistosoma mansoni nAChR subunit 0.0037 0.0083 0.0151
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0114 0.0394 0.1766
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0163 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0257 0.0976 0.1766
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0182 0.0328
Echinococcus granulosus 7tm_1 domain containing protein 0.0257 0.0976 0.1766
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.004 0.0067
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0182 0.0328
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0023 0.0119
Leishmania major cytochrome p450-like protein 0.0022 0.0023 0.0038
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0023 0.0038
Echinococcus granulosus apoptotic protease activating factor 1 0.0075 0.0238 0.043
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0152 0.0659
Schistosoma mansoni hypothetical protein 0.0069 0.0215 0.0388
Schistosoma mansoni opsin-like receptor 0.0257 0.0976 0.1766
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0015 0.0028
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0037 0.0083 0.0108
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0163 0.0274
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0058 0.0075
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Trypanosoma brucei cytochrome P450, putative 0.004 0.0095 0.0159
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0031 0.0058 0.0058
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1488 0.5958 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0019
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0058 0.0104
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0257 0.0976 0.0976
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0182 0.0182
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0239 0.0239
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0113 0.039 0.0654
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0239 1
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0135 0.0244
Plasmodium vivax SET domain protein, putative 0.0031 0.006 0.2498
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.0083 0.0151
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0018 0.0008 0.0015
Brugia malayi hypothetical protein 0.0017 0.0003 0.0004
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0023 0.0035
Onchocerca volvulus 0.0257 0.0976 0.7568
Plasmodium falciparum peptidase, putative 0.0027 0.0041 0.2537
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0023 0.0041
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0045 0.0116 0.0151
Echinococcus multilocularis serotonin receptor 0.0877 0.3482 0.3482
Echinococcus granulosus peptide allatostatin:somatostatin 0.0257 0.0976 0.1766
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0239 0.1056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0257 0.0976 0.1766
Onchocerca volvulus 0.0257 0.0976 0.7568
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0023 0.0035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0345 0.0447
Echinococcus granulosus acetylcholinesterase 0.0071 0.0223 0.0403
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0153 0.0555 0.0555
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0239 0.1267
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0083 0.0108
Trypanosoma cruzi ion transport protein, putative 0.0045 0.0116 0.0195
Loa Loa (eye worm) norepinephrine transporter 0.018 0.0663 0.086
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0031 0.0058 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0239 0.0401
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Schistosoma mansoni flap endonuclease-1 0.0024 0.0033 0.006
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0257 0.0976 0.1267
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0015 0.002
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0031 0.0058 0.0075
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.004 0.0067
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0073 0.0231 0.03
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0257 0.0976 0.1766
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0008 0.0217
Echinococcus granulosus caspase 8 0.0018 0.0008 0.0015
Echinococcus multilocularis caspase 0.0018 0.0008 0.0008
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.004 0.1679
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0113 0.039 0.039
Echinococcus granulosus 7TM GPCR rhodopsin 0.0257 0.0976 0.1766
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0 0.0012
Loa Loa (eye worm) hypothetical protein 0.0075 0.0239 0.031
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0018 0.0008 0.0011
Onchocerca volvulus 0.0037 0.0083 0.0626
Brugia malayi hypothetical protein 0.0045 0.0116 0.0151
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Brugia malayi hypothetical protein 0.0017 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Loa Loa (eye worm) hypothetical protein 0.018 0.0663 0.086
Schistosoma mansoni DNA polymerase eta 0.002 0.0015 0.0028
Entamoeba histolytica hypothetical protein 0.0073 0.0229 0.1469
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0239 0.0401
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.002 0.002
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.0083 0.0108
Schistosoma mansoni nAChR subunit 0.0037 0.0083 0.0151
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0083 0.0108
Brugia malayi prolyl oligopeptidase family protein 0.0113 0.039 0.0506
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0023 0.0038
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0257 0.0976 0.0976
Brugia malayi Serotonin receptor 0.0722 0.2858 0.3709
Toxoplasma gondii exonuclease III APE 0.0057 0.0163 0.4185
Schistosoma mansoni histamine h1 receptor 0.0257 0.0976 0.1766
Plasmodium vivax potassium channel, putative 0.0045 0.0116 0.4867
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0045 0.0116 0.0151
Echinococcus multilocularis carboxylesterase 5A 0.0071 0.0223 0.0223
Echinococcus multilocularis sex peptide receptor 0.0257 0.0976 0.0976
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0117 0.2991
Echinococcus multilocularis g-protein coupled receptor 0.0257 0.0976 0.0976
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0 0.0001
Onchocerca volvulus 0.0031 0.0058 0.0426
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0182 0.0328
Loa Loa (eye worm) hypothetical protein 0.0071 0.0223 0.029
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0163 0.0709
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0101 0.059
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0008 0.0014
Echinococcus multilocularis neuropeptide FF receptor 2 0.0257 0.0976 0.0976
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0626 0.2829
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0113 0.039 0.0654
Leishmania major DNA polymerase kappa, putative 0.002 0.0015 0.0026
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0152 0.0255
Brugia malayi Serotonin receptor 0.0257 0.0976 0.1267
Echinococcus multilocularis small conductance calcium activated potassium 0.0982 0.391 0.391
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0103 0.0134
Brugia malayi Abnormal catecholamine distribution protein 1 0.0364 0.1409 0.1829
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0019
Echinococcus granulosus geminin 0.0887 0.3525 0.6376
Schistosoma mansoni growth hormone secretagogue receptor 0.0257 0.0976 0.1766
Echinococcus multilocularis neuropeptides capa receptor 0.0257 0.0976 0.0976
Loa Loa (eye worm) hypothetical protein 0.0083 0.0269 0.035
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Onchocerca volvulus 0.0257 0.0976 0.7568
Echinococcus granulosus allatostatin A receptor 0.0257 0.0976 0.1766
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Brugia malayi acetyltransferase, GNAT family protein 0.0153 0.0555 0.072
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0117 0.0495
Brugia malayi G-protein coupled receptor 0.0257 0.0976 0.1267
Onchocerca volvulus 0.0083 0.0269 0.2066
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0113 0.039 0.0654
Echinococcus multilocularis synaptic vesicular amine transporter 0.0364 0.1409 0.1409
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0257 0.0976 0.0976
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0037 0.0083 0.0108
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0055 0.01
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0163 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0321 0.0581
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0041 0.0179
Brugia malayi hypothetical protein 0.0017 0.0003 0.0004
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0113 0.039 0.0705
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Entamoeba histolytica hypothetical protein 0.0073 0.0229 0.1469
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Entamoeba histolytica hypothetical protein 0.0073 0.0229 0.1469
Brugia malayi glutaminase DH11.1 0.0557 0.219 0.2842
Loa Loa (eye worm) MH2 domain-containing protein 0.038 0.1474 0.1913
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0663 0.3
Echinococcus granulosus nAChR subunit 0.0037 0.0083 0.0151
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0257 0.0976 0.1766
Schistosoma mansoni neuropeptide F-like receptor 0.0257 0.0976 0.1766
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0023 0.0038
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0153 0.0555 0.1003
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0626 0.2829
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0257 0.0976 0.0976
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0019
Onchocerca volvulus 0.0045 0.0116 0.0881
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0058 0.0075
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0345 0.0447
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0058 0.0104
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0135 0.0244
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0037 0.0083 0.0083
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0023 0.0119
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0027 0.0041 0.1062
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0182 0.0236
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0152 0.0255
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0058 0.0104
Schistosoma mansoni twik family of potassium channels-related 0.0045 0.0116 0.021
Trichomonas vaginalis set domain proteins, putative 0.0246 0.0931 0.4231
Onchocerca volvulus 0.0045 0.0116 0.0881
Schistosoma mansoni microtubule-associated protein tau 0.1382 0.5529 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Echinococcus multilocularis smad 0.0026 0.0039 0.0039
Trypanosoma cruzi oligopeptidase b 0.0027 0.0041 0.0069
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0041 0.0099 0.0128
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0027 0.0041 0.0855
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.0083 0.0083
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0058 0.0104
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0037 0.0083 0.0108
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0039 0.007
Schistosoma mansoni adenoreceptor 0.0257 0.0976 0.1766
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0345 0.0447
Brugia malayi Cytochrome P450 family protein 0.004 0.0095 0.0123
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0108 0.0373 0.2451
Loa Loa (eye worm) hypothetical protein 0.0877 0.3482 0.452
Echinococcus multilocularis rhodopsin orphan GPCR 0.0257 0.0976 0.0976
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0044 0.0057
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0031 0.0058 0.0104
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0037 0.0083 0.0108
Plasmodium falciparum metacaspase 1 0.0018 0.0008 0.0519
Echinococcus multilocularis rhodopsin orphan GPCR 0.0257 0.0976 0.0976
Trypanosoma brucei protein kinase, putative 0.0054 0.0152 0.0255
Onchocerca volvulus 0.0031 0.006 0.0441
Schistosoma mansoni vesicular amine transporter 0.0364 0.1409 0.2549
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0064 0.0064
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0257 0.0976 0.1267
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0257 0.0976 0.1766
Schistosoma mansoni Smad4 0.0026 0.0039 0.007
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0152 0.3907
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0481 0.1882 1
Schistosoma mansoni opsin-like receptor 0.0257 0.0976 0.1766
Loa Loa (eye worm) hypothetical protein 0.0101 0.0345 0.0447
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0017 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Echinococcus multilocularis neuropeptide receptor 0.0257 0.0976 0.0976
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0037 0.0083 0.0151
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0023 0.0035
Echinococcus multilocularis orexin receptor type 2 0.0257 0.0976 0.0976
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0257 0.0976 0.1766
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0152 0.0938
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0058 0.1481
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0135 0.0244
Brugia malayi hypothetical protein 0.0257 0.0976 0.1267
Brugia malayi sulfakinin receptor protein 0.0257 0.0976 0.1267
Echinococcus granulosus microtubule associated protein 2 0.1382 0.5529 1
Brugia malayi hypothetical protein 0.0031 0.0058 0.0075
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0023 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0026
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0239 0.1056
Echinococcus multilocularis 0.0022 0.0023 0.0023
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.004 0.0067
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0257 0.0976 0.1766
Onchocerca volvulus 0.0257 0.0976 0.7568
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Trypanosoma brucei metacaspase MCA2 0.0018 0.0008 0.0014
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0017 0.0003 0.0003
Loa Loa (eye worm) GABA receptor subunit 0.002 0.0014 0.0019
Echinococcus granulosus neuropeptide Y receptor 0.0257 0.0976 0.1766
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0163 0.0274
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0239 0.031
Echinococcus granulosus g protein coupled receptor 0.0257 0.0976 0.1766
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0257 0.0976 0.1267
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0169 0.0617 0.412
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0239 1
Brugia malayi Intermediate filament tail domain containing protein 0.0084 0.0276 0.0358
Echinococcus granulosus neuropeptide receptor 0.0257 0.0976 0.1766
Loa Loa (eye worm) hypothetical protein 0.0075 0.0239 0.031
Echinococcus granulosus hypothetical protein 0.0257 0.0976 0.1766
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0027 0.0041 0.0069
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0269 0.0486
Echinococcus granulosus acylamino acid releasing enzyme 0.0027 0.0041 0.0075
Onchocerca volvulus 0.0257 0.0976 0.7568
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0026
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0023 0.0035
Brugia malayi mbt repeat family protein 0.005 0.0135 0.0175
Brugia malayi Cation transporter family protein 0.0037 0.0083 0.0108
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0215 0.0279
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0023 0.0119
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0008 0.0355
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0335 0.1289 0.2332
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0058 0.0104
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0 0.0001
Brugia malayi cytochrome P450 0.0022 0.0023 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0152 0.0275
Onchocerca volvulus 0.0075 0.0239 0.1834
Onchocerca volvulus 0.0257 0.0976 0.7568
Echinococcus multilocularis neuropeptide receptor A26 0.0257 0.0976 0.0976
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Onchocerca volvulus 0.0037 0.0083 0.0626
Echinococcus multilocularis calcium activated potassium channel variant 0.0045 0.0116 0.0116
Schistosoma mansoni intermediate filament proteins 0.0084 0.0276 0.0499
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0023 0.0119
Mycobacterium ulcerans glutaminase 0.0557 0.219 1
Schistosoma mansoni hypothetical protein 0.0257 0.0976 0.1766
Echinococcus multilocularis neuropeptide s receptor 0.0257 0.0976 0.0976
Schistosoma mansoni twik family of potassium channels-related 0.0045 0.0116 0.021
Brugia malayi hypothetical protein 0.0086 0.0282 0.0366
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0335 0.1289 0.2332
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0015 0.0026
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0045 0.0116 0.0151
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0037 0.0083 0.0108
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0044 0.0073
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0045 0.0116 0.0151
Schistosoma mansoni caspase-3 (C14 family) 0.0018 0.0008 0.0015
Mycobacterium leprae Probable lipase LipE 0.0075 0.0239 1
Echinococcus granulosus g-protein coupled receptor 0.0257 0.0976 0.1766
Schistosoma mansoni biogenic amine receptor 0.0257 0.0976 0.1766
Loa Loa (eye worm) hypothetical protein 0.0039 0.0093 0.012
Onchocerca volvulus 0.018 0.0663 0.5131
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0075
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0023 0.0035
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0064 0.0083
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0015 0.0026
Brugia malayi AKH receptor 0.0257 0.0976 0.1267
Onchocerca volvulus 0.0045 0.0116 0.0881
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0075
Brugia malayi Cell death protein 3 precursor 0.0093 0.0312 0.0405
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.0537 0.0972
Schistosoma mansoni caspase-7 (C14 family) 0.0093 0.0312 0.0564
Schistosoma mansoni twik family of potassium channels-related 0.0045 0.0116 0.021
Brugia malayi Flap endonuclease-1 0.0027 0.0044 0.0057
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.002 0.0036
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0041 0.0054
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0041 0.0054
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0135 0.0244
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0135 0.0175
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0626 0.2829
Echinococcus granulosus lamin 0.0084 0.0276 0.0499
Schistosoma mansoni hypothetical protein 0.0257 0.0976 0.1766
Echinococcus granulosus rhodopsin orphan GPCR 0.0257 0.0976 0.1766
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0023 0.0035
Trypanosoma cruzi metacaspase, putative 0.0018 0.0008 0.0014
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0239 0.1267
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0037 0.0083 0.0108
Echinococcus granulosus rhodopsin orphan GPCR 0.0257 0.0976 0.1766
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0257 0.0976 0.1766
Brugia malayi Cytochrome P450 family protein 0.0042 0.0103 0.0134
Schistosoma mansoni amine GPCR 0.0599 0.2357 0.4264
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0058 0.0058
Onchocerca volvulus 0.0257 0.0976 0.7568
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0163 0.0163
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0045 0.0116 0.0151
Echinococcus multilocularis potassium channel subfamily K 8 0.0045 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0463 0.1808 0.2347
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Echinococcus granulosus smad 0.0026 0.0039 0.007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0023 0.0035
Onchocerca volvulus 0.0257 0.0976 0.7568
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.0626 0.4842
Echinococcus multilocularis fmrfamide receptor 0.0257 0.0976 0.0976
Loa Loa (eye worm) melatonin receptor type 1A 0.0257 0.0976 0.1267
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0064 0.0116
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0045 0.0116 0.0195
Trypanosoma cruzi metacaspase, putative 0.0018 0.0008 0.0014
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0045 0.0116 0.0151
Schistosoma mansoni neuropeptide F-like receptor 0.0257 0.0976 0.1766
Echinococcus granulosus flap endonuclease 1 0.0027 0.0044 0.0079
Echinococcus multilocularis geminin 0.0887 0.3525 0.3525
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0054
Leishmania major ion transport protein-like protein 0.0045 0.0116 0.0195
Echinococcus granulosus dna polymerase kappa 0.002 0.0015 0.0028
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0075
Loa Loa (eye worm) neuropeptide F receptor 0.0257 0.0976 0.1267
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0028 0.0721
Echinococcus granulosus nAChR subunit 0.002 0.0014 0.0026
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0027 0.0041 0.0069
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0257 0.0976 0.0976
Loa Loa (eye worm) ACC-1 protein 0.0037 0.0083 0.0108
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0099 0.0099
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0003 0.0005
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0058 0.0104
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0239 0.1056
Schistosoma mansoni nAChR subunit 0.0017 0.0003 0.0005
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0017 0.0003 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0239 0.0401
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0182 0.0328
Echinococcus multilocularis caspase 8 0.0018 0.0008 0.0008
Echinococcus granulosus glycine receptor subunit beta 0.0037 0.0083 0.0151
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Onchocerca volvulus 0.0257 0.0976 0.7568
Brugia malayi beta-lactamase family protein 0.0075 0.0239 0.031
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0626 0.2829
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0257 0.0976 0.1766
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0023 0.0119
Onchocerca volvulus 0.0045 0.0116 0.0881
Echinococcus granulosus lamin dm0 0.0084 0.0276 0.0499
Leishmania major hypothetical protein, conserved 0.0045 0.0116 0.0195
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0019
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0044 0.112
Echinococcus multilocularis dro:myosuppressin receptor 0.0257 0.0976 0.0976
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0045 0.0116 0.0116
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0045 0.0116 0.021
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Echinococcus multilocularis g protein coupled receptor 0.0257 0.0976 0.0976
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.006 0.1531
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0041 0.0075
Schistosoma mansoni hypothetical protein 0.0257 0.0976 0.1766
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0041 0.0184
Loa Loa (eye worm) transcription factor SMAD2 0.038 0.1474 0.1913
Trichomonas vaginalis esterase, putative 0.0075 0.0239 0.1056
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0028 0.1723
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0015 0.0031
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0058 0.0075
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0041 0.0179
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0083 0.0108
Echinococcus multilocularis rhodopsin orphan GPCR 0.0257 0.0976 0.0976
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0023 0.0119
Plasmodium falciparum transporter, putative 0.0031 0.0058 0.3539
Brugia malayi neuropeptide F receptor 0.0257 0.0976 0.1267
Schistosoma mansoni hypothetical protein 0.0045 0.0116 0.021
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0257 0.0976 0.1766
Brugia malayi Smad1 0.0026 0.0039 0.005
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0 0.0001
Leishmania major hypothetical protein, conserved 0.0075 0.0239 0.0401
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0163 0.0274
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0017 0.0003 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.006 0.0108
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0257 0.0976 0.1766
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0045 0.0116 0.0151
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0028 0.024
Onchocerca volvulus 0.0045 0.0116 0.0881
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0257 0.0976 0.1766
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0023 0.0119
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Brugia malayi hypothetical protein 0.0314 0.1207 0.1566
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0163 0.2126
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0257 0.0976 0.0976
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0257 0.0976 0.1766
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0045 0.0116 0.0151
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Echinococcus granulosus muscleblind protein 0.0154 0.0558 0.1009
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0027 0.0041 0.0151
Brugia malayi Dopamine receptor protein 2 0.0257 0.0976 0.1267
Onchocerca volvulus 0.0084 0.0276 0.2121
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0257 0.0976 0.1766
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Loa Loa (eye worm) acetylcholine receptor protein 0.0017 0.0003 0.0004
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0045 0.0116 0.0151
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0028 0.0721
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0058 0.2416
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0023 0.0119
Brugia malayi G-protein coupled receptor 0.0257 0.0976 0.1267
Trypanosoma brucei metacaspase MCA3 0.0018 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0075 0.0239 0.031
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Loa Loa (eye worm) serotonin transporter b 0.018 0.0663 0.086
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0058 0.0104
Brugia malayi GnHR receptor homolog 0.0257 0.0976 0.1267
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0015 0.0078
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Loa Loa (eye worm) uncoordinated protein 58 0.0045 0.0116 0.0151
Plasmodium falciparum metacaspase-like protein 0.0018 0.0008 0.0519
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Loa Loa (eye worm) hypothetical protein 0.018 0.0663 0.086
Schistosoma mansoni opsin-like receptor 0.0257 0.0976 0.1766
Brugia malayi Carboxylesterase family protein 0.0071 0.0223 0.029
Loa Loa (eye worm) hypothetical protein 0.0069 0.0215 0.0279
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0083 0.0108
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0023 0.0035
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0045 0.0116 0.0151
Echinococcus multilocularis g protein coupled receptor 0.0257 0.0976 0.0976
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0083 0.0108
Echinococcus multilocularis rhodopsin orphan GPCR 0.0257 0.0976 0.0976
Loa Loa (eye worm) glutaminase 0.0557 0.219 0.2842
Echinococcus granulosus prolyl endopeptidase 0.0027 0.0041 0.0075
Brugia malayi Isocitrate dehydrogenase 0.0016 0 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0023 0.0119
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.006 0.0108
Brugia malayi larval opioid receptor 0.0257 0.0976 0.1267
Brugia malayi Dopamine receptor 0.0257 0.0976 0.1267
Onchocerca volvulus 0.0075 0.0238 0.1824
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0055 0.0155 0.0674
Echinococcus multilocularis acetylcholinesterase 0.0071 0.0223 0.0223
Schistosoma mansoni smad1 5 8 and 0.0026 0.0039 0.007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0152 0.0255
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0027 0.0041 0.0075
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0028 0.1177
Onchocerca volvulus 0.0257 0.0976 0.7568
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0015 0.0078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0257 0.0976 0.0976
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.0083 0.0083
Echinococcus granulosus potassium channel subfamily K 8 0.0045 0.0116 0.021
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0163 0.0163
Loa Loa (eye worm) LGC-31 protein 0.0037 0.0083 0.0108
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0023 0.0035
Schistosoma mansoni hypothetical protein 0.0032 0.0064 0.0116
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0058 0.0104
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0058 0.0104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0257 0.0976 0.0976
Schistosoma mansoni calcium-activated potassium channel 0.0045 0.0116 0.021
Echinococcus granulosus G protein coupled receptor 139 0.0257 0.0976 0.1766
Brugia malayi Muscleblind-like protein 0.0154 0.0558 0.0724
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0023 0.0119
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0008 0.0217
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0045 0.0116 0.0195
Onchocerca volvulus 0.002 0.0014 0.009
Brugia malayi jmjC domain containing protein 0.0061 0.0182 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0116 0.0195
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0257 0.0976 0.1267
Onchocerca volvulus 0.0045 0.0116 0.0881
Echinococcus granulosus calcium activated potassium channel variant 0.0045 0.0116 0.021
Schistosoma mansoni amine GPCR 0.0257 0.0976 0.1766
Brugia malayi jmjC domain containing protein 0.0061 0.0182 0.0236
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0023 0.0119
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Leishmania major calcium/potassium channel (CAKC), putative 0.0045 0.0116 0.0195
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0152 0.0255
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0117 0.0152
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.006 0.0108
Leishmania major oligopeptidase b 0.0027 0.0041 0.0069
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0163 0.0709
Schistosoma mansoni neuropeptide receptor 0.0257 0.0976 0.1766
Onchocerca volvulus Cell death protein 3 homolog 0.0093 0.0312 0.2404
Echinococcus granulosus neuropeptide Y receptor 0.0257 0.0976 0.1766
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0014 0.0019
Mycobacterium tuberculosis Probable peptidase 0.0027 0.0041 0.0217
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0 0.002
Echinococcus multilocularis musashi 0.0084 0.0276 0.0276
Schistosoma mansoni calcium-activated potassium channel 0.0878 0.349 0.6312
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0113 0.039 1
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0045 0.0116 0.0195
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0054
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0058 0.1481
Echinococcus granulosus somatostatin receptor 0.0257 0.0976 0.1766
Echinococcus granulosus g protein coupled receptor 0.0257 0.0976 0.1766
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0023 0.0035
Echinococcus granulosus twik family of potassium channels 0.0045 0.0116 0.021
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0321 0.0417
Giardia lamblia Hypothetical protein 0.0045 0.0116 0.0692
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0037 0.0083 0.0151
Loa Loa (eye worm) cytochrome P450 0.0022 0.0023 0.003
Schistosoma mansoni biogenic amine (5HT) receptor 0.0877 0.3482 0.6298
Echinococcus granulosus rhodopsin orphan GPCR 0.0257 0.0976 0.1766
Brugia malayi hypothetical protein 0.0075 0.0238 0.0308
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0045 0.0116 0.0151
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0045 0.0116 0.0151
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0015 0.0026
Leishmania major DNA polymerase eta, putative 0.002 0.0015 0.0026
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Loa Loa (eye worm) intermediate filament protein 0.0084 0.0276 0.0358
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.0083 0.0151
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0031 0.0058 0.0058
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0058 0.0104
Entamoeba histolytica hypothetical protein 0.0073 0.0229 0.1469
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0023 0.0035
Onchocerca volvulus 0.0075 0.0239 0.1834
Trypanosoma cruzi oligopeptidase b 0.0027 0.0041 0.0069
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0023 0.0035
Leishmania major cytochrome p450-like protein 0.004 0.0095 0.0159
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0163 0.0294
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0037 0.0083 0.0108
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0135 0.1026
Echinococcus multilocularis dna polymerase kappa 0.002 0.0015 0.0015
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0207 0.0772 0.0772
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0257 0.0976 0.1766
Echinococcus multilocularis twik family of potassium channels 0.0045 0.0116 0.0116
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0037 0.0083 0.0108
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Schistosoma mansoni smad1 5 8 and 0.0026 0.0039 0.007
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0117 0.0211
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0027 0.0041 0.0069
Echinococcus granulosus g protein coupled receptor 0.0257 0.0976 0.1766
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0152 0.0255
Echinococcus granulosus neuropeptide FF receptor 2 0.0257 0.0976 0.1766
Onchocerca volvulus 0.0257 0.0976 0.7568
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0023 0.0119
Trypanosoma brucei oligopeptidase b 0.0027 0.0041 0.0069
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0008 0.0217
Echinococcus granulosus glycine receptor subunit beta 0.0037 0.0083 0.0151
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0257 0.0976 0.1267
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0257 0.0976 0.1766
Echinococcus granulosus tm gpcr rhodopsin 0.0257 0.0976 0.1766
Brugia malayi MH2 domain containing protein 0.038 0.1474 0.1913
Brugia malayi follicle stimulating hormone receptor 0.0257 0.0976 0.1267
Loa Loa (eye worm) hypothetical protein 0.0039 0.0093 0.012
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0015 0.0026
Schistosoma mansoni neuropeptide f receptor 76f 0.0257 0.0976 0.1766
Brugia malayi Sodium:neurotransmitter symporter family protein 0.018 0.0663 0.086
Onchocerca volvulus 0.0257 0.0976 0.7568
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0017 0.0003 0.0004
Echinococcus multilocularis nAChR subunit 0.002 0.0014 0.0014
Brugia malayi hypothetical protein 0.0257 0.0976 0.1267
Schistosoma mansoni hypothetical protein 0.0982 0.391 0.7071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0064 0.0116
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0037 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0084 0.0276 0.0358
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0044 0.0073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0321 0.0581
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0064 0.0083
Onchocerca volvulus 0.0246 0.0931 0.7219
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0988 0.4491
Echinococcus granulosus GPCR family 2 0.0032 0.0064 0.0116
Echinococcus granulosus voltage gated potassium channel 0.0021 0.002 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0257 0.0976 0.1766
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0335 0.1289 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0075
Brugia malayi Cytochrome P450 family protein 0.0022 0.0023 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Schistosoma mansoni ap endonuclease 0.0057 0.0163 0.0295
Echinococcus granulosus fmrfamide receptor 0.0257 0.0976 0.1766
Loa Loa (eye worm) ACC-1 protein 0.0037 0.0083 0.0108
Echinococcus multilocularis Smad4 0.0026 0.0039 0.0039
Echinococcus granulosus potassium channel subfamily K 0.0045 0.0116 0.021
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0015 0.0026
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0075
Echinococcus granulosus small conductance calcium activated potassium 0.0982 0.391 0.7071
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0 0.003
Schistosoma mansoni smad 0.0026 0.0039 0.007
Echinococcus multilocularis dna polymerase eta 0.002 0.0015 0.0015
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0163 0.0294
Brugia malayi putative neuropeptide receptor 0.0257 0.0976 0.1267
Brugia malayi beta-lactamase family protein 0.0075 0.0239 0.031
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Echinococcus multilocularis acylamino acid releasing enzyme 0.0027 0.0041 0.0041
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0045 0.0116 0.0696
Brugia malayi intermediate filament protein 0.0084 0.0276 0.0358
Brugia malayi excitatory GABA receptor EXP-1A 0.0037 0.0083 0.0108
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Schistosoma mansoni hypothetical protein 0.0032 0.0064 0.0116
Plasmodium falciparum potassium channel 0.0045 0.0116 0.7128
Trypanosoma cruzi metacaspase, putative 0.0018 0.0008 0.0014
Trypanosoma cruzi prolyl endopeptidase 0.0027 0.0041 0.0069
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0239 0.031
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0163 0.0274
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0169 0.0617 0.412
Loa Loa (eye worm) acetyltransferase 0.0153 0.0555 0.072
Loa Loa (eye worm) hypothetical protein 0.005 0.0135 0.0175
Loa Loa (eye worm) TWK-28 protein 0.0045 0.0116 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0988 0.4491
Echinococcus multilocularis rhodopsin orphan GPCR 0.0257 0.0976 0.0976
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0041 0.0075
Echinococcus granulosus biogenic amine 5HT receptor 0.0877 0.3482 0.6298
Brugia malayi Melatonin receptor type 1A 0.0257 0.0976 0.1267
Onchocerca volvulus 0.0314 0.1207 0.9358
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0015 0.0015
Toxoplasma gondii ion channel protein 0.0045 0.0116 0.2983
Loa Loa (eye worm) hypothetical protein 0.0314 0.1207 0.1566
Brugia malayi hypothetical protein 0.0122 0.0427 0.0554
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0257 0.0976 0.1766
Plasmodium falciparum amino acid transporter, putative 0.0031 0.0058 0.3539
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0269 0.0486
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Trichomonas vaginalis glutaminase, putative 0.0557 0.219 1
Echinococcus granulosus acetylcholinesterase 0.0071 0.0223 0.0403
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0099 0.0179
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0239 0.0432
Leishmania major C-8 sterol isomerase-like protein 0.1488 0.5958 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0023 0.0588
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0015 0.0005
Echinococcus multilocularis nAChR subunit 0.0037 0.0083 0.0083
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1488 0.5958 0.7733
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0152 0.0659
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0045 0.0116 0.0615
Entamoeba histolytica hypothetical protein 0.0023 0.0028 0.0093
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0044 0.0161
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0269 0.0349
Brugia malayi hypothetical protein 0.0257 0.0976 0.1267
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Onchocerca volvulus 0.0045 0.0116 0.0881
Schistosoma mansoni biogenic amine (5HT) receptor 0.0257 0.0976 0.1766
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0257 0.0976 0.1267
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0015 0.0031
Leishmania major metacaspase, putative 0.0018 0.0008 0.0014
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0239 0.1267
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0152 0.0659
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0117 0.4881
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0037 0.0083 0.0151
Brugia malayi prolyl oligopeptidase family protein 0.0335 0.1289 0.1673
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0152 0.0152
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0041 0.0054
Schistosoma mansoni lamin 0.0084 0.0276 0.0499
Loa Loa (eye worm) hypothetical protein 0.0032 0.0064 0.0083
Brugia malayi Pre-SET motif family protein 0.0031 0.006 0.0077
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0014 0.0019
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0015 0.002
Onchocerca volvulus 0.0045 0.0116 0.0881
Onchocerca volvulus 0.0037 0.0083 0.0626
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0257 0.0976 0.1267
Echinococcus granulosus tm gpcr rhodopsin 0.0769 0.3046 0.551
Schistosoma mansoni hypothetical protein 0.0887 0.3525 0.6376
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Schistosoma mansoni nAChR subunit 0.0037 0.0083 0.0151
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0058 0.0075
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0117 0.0495
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0045 0.0116 0.0151
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.018 0.0663 0.1199
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0101 0.0595
Echinococcus multilocularis prolyl endopeptidase 0.0027 0.0041 0.0041
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0041 0.0184
Schistosoma mansoni myosin xvIII 0.0257 0.0976 0.1766
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0075
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.002 0.002
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0041 0.0184
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0064 0.0083
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0019
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0037 0.0083 0.0108
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0182 0.0328
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0239 0.1056
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0257 0.0976 0.0976
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0041 0.0069
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0229 0.0414
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0163 0.0212
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Loa Loa (eye worm) hypothetical protein 0.0982 0.391 0.5074
Schistosoma mansoni cytochrome P450 0.0022 0.0023 0.0041
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0037 0.0083 0.0151
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0039 0.0039
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0044 0.0044
Onchocerca volvulus 0.0084 0.0276 0.2121
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0027 0.0041 0.0217
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0045 0.0116 0.0151
Schistosoma mansoni hypothetical protein 0.0073 0.0229 0.0414
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0 0.0001
Echinococcus granulosus twik family of potassium channels 0.0045 0.0116 0.021
Loa Loa (eye worm) hypothetical protein 0.192 0.7705 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0257 0.0976 0.0976
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0015 0.0026
Onchocerca volvulus 0.0031 0.0058 0.0426
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0116 0.0195
Trypanosoma brucei prolyl endopeptidase 0.0027 0.0041 0.0069
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0045 0.0116 0.0195
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0988 0.4491
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0015 0.002
Echinococcus granulosus caspase 2 0.0093 0.0312 0.0564
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0026
Toxoplasma gondii ion channel protein 0.0045 0.0116 0.2983
Echinococcus granulosus caspase 0.0018 0.0008 0.0015
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.006 0.0108
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0045 0.0116 0.0151
Loa Loa (eye worm) hypothetical protein 0.0083 0.0269 0.0349
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0152 0.0255
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.006 0.006
Brugia malayi hypothetical protein 0.0257 0.0976 0.1267
Brugia malayi neuropeptide F receptor 0.0257 0.0976 0.1267
Onchocerca volvulus 0.002 0.0014 0.009
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0031 0.0058 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Schistosoma mansoni nAChR subunit 0.0037 0.0083 0.0151
Echinococcus multilocularis G-protein coupled receptor, putative 0.0257 0.0976 0.0976
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0023 0.0119
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0321 0.0417
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0321 0.0581
Brugia malayi hypothetical protein 0.0017 0.0002 0.0003
Toxoplasma gondii hypothetical protein 0.0031 0.0058 0.1481
Schistosoma mansoni ap endonuclease 0.0057 0.0163 0.0295
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0163 0.0864
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0257 0.0976 0.0976
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.004 0.1029
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0058 0.0075
Brugia malayi Cytochrome P450 family protein 0.004 0.0095 0.0123
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0095 0.0159
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0028 0.0059
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0152 0.0255
Trypanosoma brucei prolyl oligopeptidase, putative 0.0027 0.0041 0.0069
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0163 0.6828
Loa Loa (eye worm) MBCTL1 0.0056 0.0163 0.0211
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0019
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0064 0.0192 0.0249
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0769 0.3046 0.3046
Schistosoma mansoni twik family of potassium channels-related 0.0045 0.0116 0.021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0257 0.0976 0.0976
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0163 0.0294
Schistosoma mansoni acetylcholine receptor subunit beta 0.0017 0.0003 0.0005
Schistosoma mansoni nAChR subunit 0.0037 0.0083 0.0151
Leishmania major hypothetical protein, conserved 0.0026 0.004 0.0067
Brugia malayi Carboxylesterase family protein 0.0071 0.0223 0.029
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.002
Echinococcus granulosus dna polymerase eta 0.002 0.0015 0.0028
Echinococcus granulosus alpha 1A adrenergic receptor 0.0257 0.0976 0.1766
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0257 0.0976 0.0976
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0152 0.0275
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0015 0.0028
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.0052
Loa Loa (eye worm) beta-lactamase 0.0075 0.0239 0.031
Schistosoma mansoni neuropeptide receptor 0.0257 0.0976 0.1766
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0117 0.0152
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0044 0.0073
Onchocerca volvulus Neuropeptide F receptor homolog 0.0257 0.0976 0.7568
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Brugia malayi MH2 domain containing protein 0.0026 0.0039 0.005
Trypanosoma brucei Metacaspase-4 0.0018 0.0008 0.0014
Leishmania major cytochrome p450-like protein 0.0022 0.0023 0.0038
Onchocerca volvulus 0.005 0.0135 0.1026
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0023 0.0119
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0073 0.0231 0.0418
Schistosoma mansoni neuropeptide receptor 0.0257 0.0976 0.1766
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0045 0.0116 0.0151
Onchocerca volvulus Huntingtin homolog 0.0122 0.0427 0.3298
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0019
Brugia malayi hypothetical protein 0.0073 0.0229 0.0297
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0037 0.0083 0.0151
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Echinococcus multilocularis lamin dm0 0.0084 0.0276 0.0276
Echinococcus multilocularis caspase 2 0.0093 0.0312 0.0312
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0037 0.0083 0.0108
Brugia malayi Dopamine receptor protein 1 0.192 0.7705 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0023 0.0119
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.004 0.2459
Loa Loa (eye worm) solute carrier family 6 member 4 0.018 0.0663 0.086
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0257 0.0976 0.1766
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Loa Loa (eye worm) hypothetical protein 0.0415 0.1616 0.2097
Echinococcus granulosus neuropeptide receptor 0.0257 0.0976 0.1766
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0 0.0001
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0223 0.0403
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0039 0.005
Echinococcus granulosus tm gpcr rhodopsin 0.0257 0.0976 0.1766
Brugia malayi hypothetical protein 0.0257 0.0976 0.1267
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0054
Echinococcus granulosus potassium channel subfamily K 8 0.0045 0.0116 0.021
Schistosoma mansoni hypothetical protein 0.0887 0.3525 0.6376
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.006 0.0108
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.0083 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0988 0.4491
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0037 0.0083 0.0151
Brugia malayi ORL1-like opioid receptor 0.0257 0.0976 0.1267
Schistosoma mansoni neurotransmitter gated ion channel 0.002 0.0014 0.0026
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0381 0.1476 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0257 0.0976 0.1766
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0027 0.0041 0.0069
Loa Loa (eye worm) hypothetical protein 0.0122 0.0427 0.0554
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.0077
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Plasmodium vivax amine transporter, putative 0.0031 0.0058 0.2416
Trypanosoma brucei calcium-activated potassium channel, putative 0.0045 0.0116 0.0195
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0239 0.1267
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0239 0.1267
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0037 0.0083 0.0108
Loa Loa (eye worm) G-protein coupled receptor 0.0257 0.0976 0.1267
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0663 0.3
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Mycobacterium tuberculosis Conserved protein 0.0075 0.0239 0.1267
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0017 0.0003 0.0004
Echinococcus multilocularis neuropeptide Y receptor 0.0257 0.0976 0.0976
Trypanosoma brucei unspecified product 0.002 0.0015 0.0026
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0027 0.0041 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0041 0.0069
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0113 0.039 0.0654
Schistosoma mansoni hypothetical protein 0.0032 0.0064 0.0116
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Toxoplasma gondii hypothetical protein 0.0027 0.0041 0.1062
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0037 0.0083 0.0083
Echinococcus multilocularis GPCR, family 2 0.0032 0.0064 0.0064
Schistosoma mansoni sodium/chloride dependent transporter 0.018 0.0663 0.1199
Loa Loa (eye worm) hypothetical protein 0.0075 0.0238 0.0308
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0003 0.0004
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0044 0.0194
Brugia malayi G protein-coupled receptor F59B2.13 0.0257 0.0976 0.1267
Onchocerca volvulus 0.0257 0.0976 0.7568
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0321 0.0321
Brugia malayi hypothetical protein 0.0257 0.0976 0.1267
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0152 0.0152
Brugia malayi MH1 domain containing protein 0.0026 0.0039 0.005
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Schistosoma mansoni amine GPCR 0.0257 0.0976 0.1766
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0015 0.0026
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Onchocerca volvulus 0.0075 0.0239 0.1834
Brugia malayi hypothetical protein 0.0026 0.004 0.0052
Schistosoma mansoni nAChR subunit 0.0037 0.0083 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0026
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0257 0.0976 0.1766
Loa Loa (eye worm) glutaminase 2 0.0557 0.219 0.2842
Brugia malayi hypothetical protein 0.0257 0.0976 0.1267
Schistosoma mansoni nAChR subunit 0.0017 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0019
Trypanosoma brucei metacaspase 0.0018 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0761 0.3013 0.391
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0 0.0001
Loa Loa (eye worm) Smad1 0.0026 0.0039 0.005
Leishmania major hypothetical protein, conserved 0.0045 0.0116 0.0195
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0257 0.0976 0.1766
Echinococcus multilocularis neuropeptide Y receptor 0.0257 0.0976 0.0976
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0055 0.0155 0.0674
Brugia malayi MH2 domain containing protein 0.0026 0.0039 0.005
Echinococcus multilocularis lamin 0.0084 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0037 0.0083 0.0108
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0045 0.0116 0.0151
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0239 0.1267
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Brugia malayi G protein-coupled receptor 0.0257 0.0976 0.1267
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0026
Schistosoma mansoni sodium-dependent amino acid transporter 0.0031 0.0058 0.0104
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0018 0.0008 0.0015
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0117 0.2991
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0258 0.0467
Brugia malayi Pre-SET motif family protein 0.0216 0.081 0.1052
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0095 0.0123
Schistosoma mansoni twik family of potassium channels-related 0.0045 0.0116 0.021
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0037 0.0083 0.0083
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0037 0.0083 0.0151
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0015 0.0026
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0045 0.0116 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0026
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0135 0.0135
Onchocerca volvulus 0.0257 0.0976 0.7568
Loa Loa (eye worm) hypothetical protein 0.018 0.0663 0.086
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0269 0.0269
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0028 0.0047
Echinococcus granulosus dro:myosuppressin receptor 0.0257 0.0976 0.1766
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0152 0.0275
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0626 0.2829
Echinococcus multilocularis g protein coupled receptor 0.0257 0.0976 0.0976
Mycobacterium ulcerans transmembrane cation transporter 0.0045 0.0116 0.0464
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0258 0.0467
Loa Loa (eye worm) hypothetical protein 0.0169 0.0617 0.08
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0017 0.0003 0.0004
Schistosoma mansoni calcium-activated potassium channel 0.0045 0.0116 0.021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0321 0.0581
Echinococcus granulosus rhodopsin orphan GPCR 0.0257 0.0976 0.1766
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0257 0.0976 0.1766
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.0083 0.0108
Loa Loa (eye worm) hypothetical protein 0.0075 0.0239 0.031
Schistosoma mansoni neuropeptide receptor 0.0257 0.0976 0.1766
Schistosoma mansoni hypothetical protein 0.0032 0.0064 0.0116
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0152 0.0198
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0182 0.0182
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0003 0.0005
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0041 0.0054
Schistosoma mansoni caspase-7 (C14 family) 0.0018 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Schistosoma mansoni twik family of potassium channels-related 0.0045 0.0116 0.021
Echinococcus granulosus neuropeptides capa receptor 0.0257 0.0976 0.1766
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0019
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.002 0.0036
Toxoplasma gondii prolyl endopeptidase 0.0027 0.0041 0.1062
Brugia malayi MAP kinase sur-1 0.0054 0.0152 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0026
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0041 0.0184
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0135 0.0244
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0 0.0001
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0044 0.1827
Loa Loa (eye worm) G-protein coupled receptor 0.0257 0.0976 0.1267
Echinococcus multilocularis muscleblind protein 0.0154 0.0558 0.0558
Entamoeba histolytica hypothetical protein 0.0108 0.0373 0.2451
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0037 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0154 0.0558 0.0724
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0045 0.0116 0.0195
Echinococcus multilocularis microtubule associated protein 2 0.1382 0.5529 0.5529
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0163 0.0212
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0058 0.1481
Echinococcus multilocularis glycine receptor subunit beta 0.0037 0.0083 0.0083
Toxoplasma gondii ABC1 family protein 0.0075 0.0239 0.6129
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0257 0.0976 0.1766
Brugia malayi hypothetical protein 0.0017 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0041 0.0151
Loa Loa (eye worm) hypothetical protein 0.0122 0.0427 0.0554
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.026 0.0988 0.1283
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0058 0.0058
Schistosoma mansoni twik family of potassium channels-related 0.0045 0.0116 0.021
Onchocerca volvulus 0.0031 0.0058 0.0426
Loa Loa (eye worm) hypothetical protein 0.0075 0.0239 0.031
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0045 0.0116 0.0494
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0041 0.0184
Loa Loa (eye worm) hypothetical protein 0.0086 0.0282 0.0366
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0257 0.0976 0.0976
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.0083 0.0151
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0335 0.1289 0.1289
Onchocerca volvulus 0.0248 0.0938 0.7269
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0027 0.0041 0.0069
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0163 0.0295
Schistosoma mansoni amine GPCR 0.0257 0.0976 0.1766
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0023 0.0035
Schistosoma mansoni hypothetical protein 0.0257 0.0976 0.1766
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0152 0.0659
Schistosoma mansoni hypothetical protein 0.0075 0.0238 0.043
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0988 0.4491
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0239 0.1056
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0075
Echinococcus multilocularis serotonin receptor 0.0877 0.3482 0.3482
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0037 0.0083 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0026
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0017 0.0003 0.0003
Echinococcus multilocularis potassium channel subfamily K 8 0.0045 0.0116 0.0116
Onchocerca volvulus 0.0037 0.0083 0.0626
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0257 0.0976 0.1267
Echinococcus granulosus sex peptide receptor 0.0257 0.0976 0.1766
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.0083 0.0151
Echinococcus granulosus carboxylesterase 5A 0.0071 0.0223 0.0403
Echinococcus multilocularis fmrfamide receptor 0.0257 0.0976 0.0976
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0023 0.0119
Echinococcus multilocularis twik family of potassium channels 0.0045 0.0116 0.0116
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0041 0.1733
Echinococcus multilocularis potassium channel subfamily K 0.0045 0.0116 0.0116
Echinococcus granulosus rhodopsin orphan GPCR 0.0257 0.0976 0.1766
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.026 0.0988 0.1283
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0037 0.0083 0.0083
Brugia malayi mbt repeat family protein 0.005 0.0135 0.0175
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0229 0.0229
Schistosoma mansoni smad1 5 8 and 0.0026 0.0039 0.007
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.002 0.0036
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0108
Onchocerca volvulus 0.0257 0.0976 0.7568
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0073 0.0231 0.0231
Brugia malayi putative neuropeptide receptor NPR1 0.0257 0.0976 0.1267
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0045 0.0116 0.0116
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0045 0.0116 0.0151
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.006 0.006
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0113 0.039 0.0654
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0026
Schistosoma mansoni nAChR subunit 0.0037 0.0083 0.0151
Loa Loa (eye worm) prolyl oligopeptidase 0.0335 0.1289 0.1673
Echinococcus granulosus neuropeptide receptor A26 0.0257 0.0976 0.1766
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0039 0.0039
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0045 0.0116 0.0151
Mycobacterium ulcerans ion transport protein 0.0045 0.0116 0.0464
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.004 0.2459
Loa Loa (eye worm) hypothetical protein 0.1488 0.5958 0.7733
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0211
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0017 0.0003 0.0005
Echinococcus granulosus serotonin transporter 0.018 0.0663 0.1199
Loa Loa (eye worm) neuropeptide F receptor 0.0257 0.0976 0.1267
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0163 0.0163
Toxoplasma gondii hypothetical protein 0.0031 0.0058 0.1481
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0163 0.068
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0037 0.0083 0.0151
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0027 0.0041 0.012
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0041 0.0184
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0015 0.0026
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0018 0.0008 0.0008
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.0083 0.0083
Loa Loa (eye worm) acetylcholinesterase 1 0.0071 0.0223 0.029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0257 0.0976 0.0976
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0028 0.0147
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0023 0.0035
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0014 0.0019
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0037 0.0083 0.0151
Mycobacterium ulcerans lipase LipD 0.0075 0.0239 0.1028
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0239 0.1028
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0084 0.0276 0.0358
Mycobacterium ulcerans beta-lactamase 0.0075 0.0239 0.1028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0321 0.0581
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.002 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0988 0.4491
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Schistosoma mansoni calcium-activated potassium channel 0.0982 0.391 0.7071
Schistosoma mansoni acetylcholine receptor-related 0.0017 0.0003 0.0005
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0239 0.1267
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0095 0.0367
Trypanosoma cruzi ion transport protein, putative 0.0045 0.0116 0.0195
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Trypanosoma brucei C-8 sterol isomerase, putative 0.1488 0.5958 1
Schistosoma mansoni glutaminase 0.0557 0.219 0.3961
Schistosoma mansoni hypothetical protein 0.0313 0.1201 0.2173
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0039 0.007
Onchocerca volvulus 0.0037 0.0083 0.0626
Echinococcus multilocularis neuropeptides capa receptor 0.0257 0.0976 0.0976
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0364 0.1409 0.1829
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Onchocerca volvulus 0.0257 0.0976 0.7568
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.002 0.0014 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0023 0.0119
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Echinococcus multilocularis muscleblind protein 1 0.0154 0.0558 0.0558
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0207 0.0772 0.1396
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.0083 0.0151
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0045 0.0116 0.0151
Echinococcus granulosus intermediate filament protein 0.0084 0.0276 0.0499
Mycobacterium tuberculosis Conserved protein 0.0075 0.0239 0.1267
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0041 0.0075
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0163 0.1017
Brugia malayi isocitrate dehydrogenase 0.0016 0 0.0001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0239 0.1028
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0037 0.0083 0.0108
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0071 0.0223 0.029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0004
Brugia malayi MH1 domain containing protein 0.0026 0.0039 0.005
Schistosoma mansoni amine GPCR 0.0257 0.0976 0.1766
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0031 0.0058 0.0058
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0239 0.0432
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.002 0.0014 0.0019
Onchocerca volvulus 0.0037 0.0083 0.0626
Loa Loa (eye worm) TWK-7 protein 0.0045 0.0116 0.0151
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0095 0.0159
Giardia lamblia DNA repair protein RAD52 0.0381 0.1476 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0257 0.0976 0.1267
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0626 0.2829
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0257 0.0976 0.1766
Schistosoma mansoni hypothetical protein 0.0022 0.0023 0.0041
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.081 0.1052
Schistosoma mansoni twik family of potassium channels-related 0.0045 0.0116 0.021
Plasmodium vivax metacaspase 1, putative 0.0018 0.0008 0.0355
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0229 0.0414
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Echinococcus multilocularis allatostatin A receptor 0.0257 0.0976 0.0976
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0257 0.0976 0.1766
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0073 0.0231 0.03
Schistosoma mansoni biogenic amine receptor 0.0257 0.0976 0.1766
Echinococcus multilocularis somatostatin receptor 0.0257 0.0976 0.0976
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.0083 0.0108
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0003 0.0004
Loa Loa (eye worm) CYP4Cod1 0.004 0.0095 0.0123
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0014 0.0026
Schistosoma mansoni lamin 0.0084 0.0276 0.0499
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0003 0.0004
Schistosoma mansoni biogenic amine receptor 0.0257 0.0976 0.1766
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.006 0.0108
Echinococcus granulosus synaptic vesicular amine transporter 0.0364 0.1409 0.2549
Plasmodium falciparum potassium channel 0.0045 0.0116 0.7128
Echinococcus granulosus neuropeptide s receptor 0.0257 0.0976 0.1766
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Loa Loa (eye worm) hypothetical protein 0.0075 0.0239 0.031
Echinococcus multilocularis glycine receptor subunit beta 0.0037 0.0083 0.0083
Echinococcus multilocularis acetylcholinesterase 0.0071 0.0223 0.0223
Echinococcus granulosus Dipeptidyl peptidase 9 0.0113 0.039 0.0705
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0027 0.0041 0.0151
Brugia malayi hypothetical protein 0.0017 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0045 0.0116 0.0151
Treponema pallidum sodium- and chloride- dependent transporter 0.018 0.0663 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0312 0.0405
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0015 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0023 0.0119
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0044 0.02
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0037 0.0083 0.0151
Echinococcus granulosus biogenic amine 5HT receptor 0.0257 0.0976 0.1766
Brugia malayi hypothetical protein 0.0257 0.0976 0.1267
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0239 0.0432
Loa Loa (eye worm) carboxylesterase 0.0071 0.0223 0.029
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0163 0.0211
Onchocerca volvulus Huntingtin homolog 0.0122 0.0427 0.3298
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0037 0.0083 0.0083
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0023 0.0119
Mycobacterium tuberculosis Conserved protein 0.0075 0.0239 0.1267
Echinococcus granulosus rhodopsin orphan GPCR 0.0257 0.0976 0.1766
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0028 0.0059
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Loa Loa (eye worm) TYRA-2 protein 0.0257 0.0976 0.1267
Echinococcus multilocularis serotonin transporter 0.018 0.0663 0.0663
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Brugia malayi Cation transporter family protein 0.0037 0.0083 0.0108
Brugia malayi Tachykinin-like peptides receptor 99D 0.0257 0.0976 0.1267
Echinococcus multilocularis apoptotic protease activating factor 1 0.0075 0.0238 0.0238
Brugia malayi hypothetical protein 0.0257 0.0976 0.1267
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0257 0.0976 0.1766
Leishmania major potassium channel subunit-like protein 0.0045 0.0116 0.0195
Brugia malayi Cation transporter family protein 0.0037 0.0083 0.0108
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0058 0.0104
Mycobacterium ulcerans hypothetical protein 0.0075 0.0239 0.1028
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0015 0.0026
Loa Loa (eye worm) hypothetical protein 0.0257 0.0976 0.1267
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0023 0.0035
Echinococcus granulosus orexin receptor type 2 0.0257 0.0976 0.1766
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0058 0.0104
Loa Loa (eye worm) hypothetical protein 0.0059 0.0171 0.0222

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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