Detailed information for compound 1372923

Basic information

Technical information
  • TDR Targets ID: 1372923
  • Name: [2-oxo-2-(propylcarbamoylamino)ethyl] 3-[(3,4 -difluorophenyl)sulfonylamino]benzoate
  • MW: 455.432 | Formula: C19H19F2N3O6S
  • H donors: 3 H acceptors: 5 LogP: 2.9 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNC(=O)NC(=O)COC(=O)c1cccc(c1)NS(=O)(=O)c1ccc(c(c1)F)F
  • InChi: 1S/C19H19F2N3O6S/c1-2-8-22-19(27)23-17(25)11-30-18(26)12-4-3-5-13(9-12)24-31(28,29)14-6-7-15(20)16(21)10-14/h3-7,9-10,24H,2,8,11H2,1H3,(H2,22,23,25,27)
  • InChiKey: RNXVKBAIHXCVRE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(3,4-difluorophenyl)sulfonylamino]benzoic acid [2-oxo-2-[(oxo-propylaminomethyl)amino]ethyl] ester
  • 3-[(3,4-difluorophenyl)sulfonylamino]benzoic acid [2-keto-2-(propylcarbamoylamino)ethyl] ester
  • T5243568
  • MLS000417853
  • SMR000243352
  • ZINC02651711

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi FAD binding domain containing protein 0.0168 0.2933 0.928
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0046
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0105 0.0329
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.019 0.0405
Echinococcus multilocularis chromobox protein 1 0.0075 0.1239 0.1239
Loa Loa (eye worm) hypothetical protein 0.0011 0.0074 0.0235
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0378 0.1187
Schistosoma mansoni hypothetical protein 0.0019 0.0229 0.072
Brugia malayi Guanylate kinase family protein 0.0007 0.0015 0.0046
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0019 0.023 0.023
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0061 0.0061
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0378 0.0378
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0202 0.0445
Onchocerca volvulus 0.0012 0.0105 0.0353
Echinococcus granulosus cytochrome b5 reductase 4 0.0019 0.023 0.023
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0064 0.105 0.3411
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0105 0.0329
Brugia malayi MH2 domain containing protein 0.0144 0.2502 0.7918
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Leishmania major hypothetical protein, conserved 0.0064 0.105 0.3275
Schistosoma mansoni DNA helicase recq5 0.0011 0.0076 0.0238
Treponema pallidum flavodoxin 0.0064 0.105 1
Echinococcus multilocularis dna polymerase eta 0.0048 0.0754 0.0754
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0543
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0258 0.0644
Trypanosoma brucei oxidoreductase-protein, putative 0.0019 0.023 0.0543
Leishmania major nitrate reductase, putative 0.0019 0.023 0.0347
Echinococcus granulosus partitioning defective 3 0.0007 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0254 0.0627
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0257 0.0808
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0007 0.0015 0.0046
Brugia malayi Heterochromatin protein 1 0.0075 0.1239 0.3919
Entamoeba histolytica modulator of drug activity B homolog, putative 0.002 0.0254 0.1838
Giardia lamblia NADPH oxidoreductase, putative 0.0082 0.1367 0.5146
Echinococcus granulosus bloom syndrome protein 0.0026 0.035 0.035
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0105 0.0106
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0105 0.0311
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.1982 0.8844
Schistosoma mansoni diflavin oxidoreductase 0.0083 0.1396 0.4391
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0202 0.0247
Loa Loa (eye worm) hypothetical protein 0.0168 0.2933 0.928
Echinococcus granulosus Microtubule-associated serine/threonine-protein kinase 0.0007 0.0015 0.0015
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0007 0.0015 0.0015
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0168 0.2933 1
Entamoeba histolytica type A flavoprotein, putative 0.0064 0.105 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0887 0.0887
Schistosoma mansoni afadin (af-6 protein) 0.0007 0.0015 0.0046
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0495 0.3182
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0168 0.2933 1
Brugia malayi hypothetical protein 0.0007 0.0015 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0105 0.0329
Schistosoma mansoni regulator of G protein signaling 0.0007 0.0015 0.0046
Schistosoma mansoni cytochrome B5 0.0019 0.023 0.0722
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0105 0.0331
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0105 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0258 0.0644
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0105 0.0329
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0543
Schistosoma mansoni NADPH flavin oxidoreductase 0.0085 0.142 0.4464
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.039 0.1102
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0019 0.023 0.023
Schistosoma mansoni maguk P55 subfamily member 35 0.0007 0.0015 0.0046
Schistosoma mansoni hypothetical protein 0.0019 0.0229 0.072
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0202 0.0445
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0258 0.0644
Echinococcus granulosus PRKCA binding protein 0.0007 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1367 0.4522
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0257 0.0808
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.2216 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0105 0.0331
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1193 0.1193
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0105 0.0106
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0064 0.105 0.3411
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1367 0.4522
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0202 0.0445
Loa Loa (eye worm) glutathione reductase 0.0051 0.0803 0.254
Plasmodium vivax flavodoxin domain containing protein 0.0149 0.2586 0.8787
Brugia malayi FAD binding domain containing protein 0.0104 0.1766 0.5588
Schistosoma mansoni pdz domain containing protein 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Echinococcus multilocularis syndecan binding protein (syntenin) 0.0007 0.0015 0.0015
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0132 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0105 0.0331
Brugia malayi PDZ domain containing protein 0.0007 0.0015 0.0046
Trypanosoma brucei nitrate reductase, putative 0.0019 0.023 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0105 0.0106
Loa Loa (eye worm) X11 protein 0.0007 0.0015 0.0046
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0064 0.105 0.3411
Echinococcus multilocularis Smad4 0.001 0.0061 0.0061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0887 0.2805
Echinococcus granulosus pdz domain containing protein 0.0007 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Schistosoma mansoni chromobox protein 0.0012 0.0105 0.0329
Loa Loa (eye worm) hypothetical protein 0.0011 0.0076 0.0239
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0007 0.0015 0.0015
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0105 0.0311
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0007 0.0015 0.0015
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0105 0.0352
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Echinococcus granulosus Smad4 0.001 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0046
Brugia malayi glutathione reductase 0.0051 0.0803 0.254
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0105 0.0106
Loa Loa (eye worm) hypothetical protein 0.0048 0.0754 0.2386
Loa Loa (eye worm) FAD binding domain-containing protein 0.0104 0.1766 0.5588
Echinococcus multilocularis chromobox protein 2 0.0012 0.0105 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0142 0.0236
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0887 0.0887
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0887 0.2788
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.0754 0.2377
Echinococcus granulosus dna polymerase kappa 0.0021 0.0258 0.0258
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0046
Trichomonas vaginalis sulfite reductase, putative 0.0168 0.2933 1
Echinococcus multilocularis tight junction protein ZO 3 0.0007 0.0015 0.0015
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.07 0.2683
Echinococcus multilocularis Chromo domain 0.0012 0.0105 0.0105
Schistosoma mansoni hypothetical protein 0.0041 0.0631 0.1983
Echinococcus multilocularis muscleblind protein 0.018 0.3161 0.3161
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0105 0.0331
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0105 0.0105
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0105 0.0311
Schistosoma mansoni Smad4 0.001 0.0061 0.0193
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0007 0.0015 0.0015
Schistosoma mansoni smad1 5 8 and 0.001 0.0061 0.0193
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0074 0.0235
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0105 0.0329
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0007 0.0015 0.0046
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0117 0.037
Echinococcus multilocularis amyloid beta A4 protein 0.0007 0.0015 0.0015
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0105 0.0106
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0105 0.0106
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.1982 0.8906
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0887 0.0887
Brugia malayi hypothetical protein 0.0007 0.0015 0.0046
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0202 0.0445
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.019 0.019
Leishmania major NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0347
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0803 0.254
Brugia malayi Neurabin protein 1 0.0007 0.0015 0.0046
Echinococcus granulosus MAGUK p55 subfamily 0.0007 0.0015 0.0015
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0064 0.105 0.3411
Brugia malayi PDZ domain containing protein 0.0007 0.0015 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0254 0.0627
Echinococcus granulosus MAGUK p55 subfamily 0.0007 0.0015 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0105 0.0106
Echinococcus granulosus disks large 1 0.0007 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0148 0.2571 0.8135
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0007 0.0015 0.0046
Brugia malayi C2 domain containing protein 0.0007 0.0015 0.0046
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0015 0.0046
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0254 0.0627
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0105 0.0106
Brugia malayi nuclear receptor NHR-88 0.0012 0.0105 0.0331
Brugia malayi MH2 domain containing protein 0.001 0.0061 0.0194
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0019 0.023 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0421 0.1212
Echinococcus multilocularis pdz domain containing protein 0.0007 0.0015 0.0015
Trypanosoma cruzi reductase, putative 0.0019 0.023 0.0543
Giardia lamblia DINP protein human, muc B family 0.0021 0.0258 0.0732
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0105 0.0329
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0147 0.0464
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0105 0.0331
Brugia malayi Flap endonuclease-1 0.0028 0.039 0.1233
Brugia malayi PX domain containing protein 0.0007 0.0015 0.0046
Brugia malayi MH1 domain containing protein 0.001 0.0061 0.0194
Echinococcus granulosus ligand of numb protein x 2 0.0007 0.0015 0.0015
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0007 0.0015 0.0015
Echinococcus multilocularis PDZ domain containing protein GIPC3 0.0007 0.0015 0.0015
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0019 0.023 0.0726
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0105 0.0106
Schistosoma mansoni tight junction protein 0.0007 0.0015 0.0046
Brugia malayi PHD-finger family protein 0.003 0.0429 0.1359
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.039 0.1233
Brugia malayi microtubule-associated serine/threonine protein kinase 2 (MAST2) 0.0007 0.0015 0.0046
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.019 0.019
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0583 0.1833
Trichomonas vaginalis chromobox protein, putative 0.0045 0.07 0.219
Schistosoma mansoni multiple pdz domain protein 0.0007 0.0015 0.0046
Onchocerca volvulus 0.0011 0.0074 0.0234
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0293 0.0765
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0803 0.0803
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0019 0.023 0.0543
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.1982 0.8844
Trypanosoma brucei NADH-dependent fumarate reductase 0.0019 0.023 0.0543
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.1982 0.8844
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0007 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0052 0.0819 0.259
Echinococcus multilocularis Partitioning defective 3 protein B 0.0007 0.0015 0.0015
Echinococcus multilocularis MAGUK p55 subfamily 0.0007 0.0015 0.0015
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0977 0.309
Schistosoma mansoni zinc finger protein 0.0018 0.0219 0.0687
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0258 0.0644
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0105 0.0105
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0202 0.0963
Schistosoma mansoni PDZ domain protein 0.0007 0.0015 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0254 0.0627
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0019 0.023 0.1174
Loa Loa (eye worm) hypothetical protein 0.0042 0.0643 0.2034
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0257 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0254 0.0627
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.0076 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0142 0.0236
Loa Loa (eye worm) hypothetical protein 0.0011 0.0074 0.0235
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0007 0.0015 0.0015
Echinococcus granulosus rho guanine nucleotide exchange factor 12 0.0007 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0105 0.0106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Echinococcus multilocularis protein piccolo 0.0007 0.0015 0.0015
Echinococcus granulosus neurabin 1 0.0007 0.0015 0.0015
Trypanosoma cruzi oxidoreductase-protein, putative 0.0019 0.023 0.0543
Schistosoma mansoni lin-7-like proteins 0.0007 0.0015 0.0046
Entamoeba histolytica hypothetical protein 0.0012 0.0105 0.0311
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0105 0.0106
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0168 0.2933 1
Mycobacterium tuberculosis Probable monooxygenase 0.0019 0.023 0.0194
Echinococcus multilocularis glutamate receptor interacting protein 1 0.0007 0.0015 0.0015
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0007 0.0015 0.0015
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0019 0.023 0.0543
Schistosoma mansoni cell polarity protein 0.0007 0.0015 0.0046
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0105 0.0331
Schistosoma mansoni multiple pdz domain protein 0.0007 0.0015 0.0046
Echinococcus granulosus amyloid beta A4 protein 0.0007 0.0015 0.0015
Loa Loa (eye worm) PDZ-domain-containing protein scribble 0.0007 0.0015 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0105 0.0106
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0076 0.0076
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0105 0.0329
Schistosoma mansoni hypothetical protein 0.0019 0.0229 0.072
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0254 0.0627
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0202 0.0638
Loa Loa (eye worm) hypothetical protein 0.0049 0.0777 0.2458
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0258 0.0644
Onchocerca volvulus 0.0012 0.0105 0.0353
Brugia malayi topoisomerase 0.0011 0.0074 0.0235
Leishmania major trypanothione reductase 0.0051 0.0803 0.2394
Echinococcus multilocularis segment polarity protein dishevelled 0.0007 0.0015 0.0015
Brugia malayi hypothetical protein 0.0012 0.0105 0.0331
Schistosoma mansoni multiple pdz domain protein 0.0007 0.0015 0.0046
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.2216 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0105 0.0105
Entamoeba histolytica type A flavoprotein, putative 0.0064 0.105 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0105 0.0106
Entamoeba histolytica hypothetical protein 0.002 0.0254 0.1838
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Echinococcus granulosus MAGUK p55 subfamily 0.0007 0.0015 0.0015
Schistosoma mansoni pdz and lim domain protein 0.0007 0.0015 0.0046
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0258 0.0644
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0007 0.0015 0.0015
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0061 0.0194
Schistosoma mansoni syntenin 0.0007 0.0015 0.0046
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.039 0.1102
Echinococcus multilocularis cytochrome b5 reductase 4 0.0019 0.023 0.023
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.039 0.1102
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0378 0.0378
Echinococcus granulosus cytochrome b5 reductase 4 0.0019 0.023 0.023
Echinococcus granulosus protein lin 7 B 0.0007 0.0015 0.0015
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2502 0.7918
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0202 0.0445
Echinococcus granulosus multiple pdz domain protein 0.0007 0.0015 0.0015
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0105 0.0106
Schistosoma mansoni flap endonuclease-1 0.0025 0.0341 0.1072
Trypanosoma brucei unspecified product 0.0014 0.0142 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0254 0.0627
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0258 0.045
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0543
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0007 0.0015 0.0015
Trypanosoma cruzi ISWI complex protein 0.0018 0.0219 0.0504
Echinococcus multilocularis ligand of numb protein x 2 0.0007 0.0015 0.0015
Schistosoma mansoni DNA ligase IV 0.0011 0.0074 0.0234
Brugia malayi hypothetical protein 0.0007 0.0015 0.0046
Brugia malayi PDZ domain 0.0007 0.0015 0.0046
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0258 0.0644
Loa Loa (eye worm) PX domain-containing protein 0.0007 0.0015 0.0046
Entamoeba histolytica hypothetical protein 0.0039 0.0583 0.5214
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0168 0.2933 1
Leishmania major oxidoreductase-like protein 0.0019 0.023 0.0347
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.002 0.0254 0.1838
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0643 0.1988
Echinococcus granulosus flap endonuclease 1 0.0028 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0105 0.0331
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0887 0.0887
Loa Loa (eye worm) hypothetical protein 0.0085 0.1435 0.4539
Echinococcus multilocularis MAGUK p55 subfamily 0.0007 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0082 0.1367 0.4522
Mycobacterium ulcerans electron transfer protein FdxB 0.0019 0.023 0.0543
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0105 0.0331
Loa Loa (eye worm) hypothetical protein 0.0011 0.0074 0.0235
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0202 0.0634
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Loa Loa (eye worm) syntrophin-1 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0258 0.0812
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0105 0.0331
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0105 0.0105
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0019 0.023 0.0543
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0147 0.0147
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0076 0.0009
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0202 0.0445
Echinococcus granulosus Chromo domain 0.0012 0.0105 0.0105
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0064 0.105 0.3411
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0803 0.2549
Brugia malayi hypothetical protein 0.0011 0.0074 0.0235
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0007 0.0015 0.0015
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Schistosoma mansoni pdz domain containing protein 0.0007 0.0015 0.0046
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0105 0.0329
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0076 0.0239
Loa Loa (eye worm) helicase 0.0012 0.0105 0.0331
Loa Loa (eye worm) Smad1 0.001 0.0061 0.0194
Schistosoma mansoni hypothetical protein 0.0018 0.0219 0.0687
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0074 0.0234
Echinococcus multilocularis PRKCA binding protein 0.0007 0.0015 0.0015
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0202 1
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0007 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1367 0.4522
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0007 0.0015 0.0015
Brugia malayi PDZ domain containing protein 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Echinococcus granulosus chromobox protein 1 0.0075 0.1239 0.1239
Loa Loa (eye worm) hypothetical protein 0.006 0.0977 0.309
Giardia lamblia Hypothetical protein 0.0149 0.2586 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0046 0.0725 0.2293
Echinococcus granulosus myeloid:lymphoid or mixed lineage leukemia 0.0007 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0181 0.318 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Loa Loa (eye worm) RecQ helicase 0.0026 0.035 0.1107
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.035 0.0964
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0105 0.0331
Schistosoma mansoni chromobox protein 0.0075 0.1239 0.3895
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0202 0.0445
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0977 0.309
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0258 0.0258
Echinococcus granulosus glutamate receptor interacting protein 1 0.0007 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Plasmodium falciparum thioredoxin reductase 0.0051 0.0803 0.2549
Echinococcus granulosus syndecan binding protein syntenin 0.0007 0.0015 0.0015
Loa Loa (eye worm) diaphorase 0.0019 0.023 0.0726
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0007 0.0015 0.0015
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0064 0.105 0.3411
Loa Loa (eye worm) hypothetical protein 0.018 0.3161 1
Trypanosoma cruzi nitrate reductase, putative 0.0019 0.023 0.0543
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0105 0.0105
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0202 0.0445
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0105 0.0105
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0007 0.0015 0.0015
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Brugia malayi protein kinase C-binding protein PICK1 0.0007 0.0015 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0064 0.105 0.3411
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0064 0.105 0.3411
Leishmania major hypothetical protein, conserved 0.0018 0.0219 0.0308
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0105 0.0105
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.023 0.0194
Echinococcus granulosus chromobox protein 1 0.0075 0.1239 0.1239
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1367 0.4522
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.027 0.0856
Brugia malayi ecdysteroid receptor 0.0012 0.0105 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0105 0.0331
Brugia malayi Muscleblind-like protein 0.018 0.3161 1
Echinococcus multilocularis methionine synthase reductase 0.0104 0.1766 0.1766
Echinococcus granulosus GPCR family 2 0.0019 0.0229 0.0229
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0076 0.0004
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0543
Brugia malayi rho guanine nucleotide exchange factor 12 0.0007 0.0015 0.0046
Leishmania major NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0347
Mycobacterium ulcerans oxygenase 0.0019 0.023 0.0543
Leishmania major NADH-dependent fumarate reductase, putative 0.0019 0.023 0.0347
Giardia lamblia NADPH oxidoreductase, putative 0.0082 0.1367 0.5146
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0258 0.0644
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0202 0.0247
Schistosoma mansoni multiple pdz domain protein 0.0007 0.0015 0.0046
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0258 0.1886
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Toxoplasma gondii flavodoxin domain-containing protein 0.0083 0.1396 1
Schistosoma mansoni hypothetical protein 0.0019 0.0229 0.072
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0229 0.0229
Echinococcus multilocularis protein lin 7 B 0.0007 0.0015 0.0015
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0195 0.0912
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0061 0.0061
Echinococcus multilocularis Rho GTPase activating protein 21 0.0007 0.0015 0.0015
Schistosoma mansoni Patj homolog 0.0007 0.0015 0.0046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0583 0.0583
Echinococcus multilocularis chromobox protein 1 0.0075 0.1239 0.1239
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0543
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0148 0.2571 0.8135
Brugia malayi PDZ domain 0.0007 0.0015 0.0046
Brugia malayi Ferm domain 0.0007 0.0015 0.0046
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0105 0.0229
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0019 0.023 0.0543
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0105 0.0106
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0202 0.0445
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0671 0.0671
Echinococcus granulosus segment polarity protein dishevelled 0.0007 0.0015 0.0015
Mycobacterium tuberculosis Possible oxygenase 0.0019 0.023 0.0194
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0007 0.0015 0.0046
Echinococcus multilocularis muscleblind protein 1 0.018 0.3161 0.3161
Echinococcus multilocularis partitioning defective 3 0.0007 0.0015 0.0015
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0495 0.1472
Schistosoma mansoni DNA polymerase eta 0.0048 0.0754 0.2371
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0199 0.0435
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0105 0.0331
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0105 0.0106
Brugia malayi nuclear hormone receptor 0.0012 0.0105 0.0331
Entamoeba histolytica type A flavoprotein, putative 0.0064 0.105 1
Echinococcus multilocularis flap endonuclease 1 0.0028 0.039 0.039
Echinococcus multilocularis 0.0007 0.0015 0.0015
Loa Loa (eye worm) DIX domain-containing protein 0.0007 0.0015 0.0046
Echinococcus granulosus disks large 3 0.0007 0.0015 0.0015
Brugia malayi Hypothetical 13.5 kDa protein C45G9.7 in chromosome III 0.0007 0.0015 0.0046
Schistosoma mansoni dishevelled 0.0007 0.0015 0.0046
Echinococcus multilocularis pdz domain containing protein 0.0007 0.0015 0.0015
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0105 0.0329
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0105 0.0329
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0007 0.0015 0.0046
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0754 0.2377
Leishmania major p450 reductase, putative 0.0168 0.2933 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0105 0.0331
Trypanosoma brucei NADH-dependent fumarate reductase 0.0019 0.023 0.0543
Onchocerca volvulus 0.0033 0.0479 0.1815
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0257 0.0257
Leishmania major cytochrome P450 reductase, putative 0.0149 0.2586 0.8762
Echinococcus granulosus methionine synthase reductase 0.0104 0.1766 0.1766
Echinococcus multilocularis nibrin 0.0011 0.0074 0.0074
Brugia malayi Guanylate kinase family protein 0.0007 0.0015 0.0046
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0019 0.023 0.1227
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0643 0.2457
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0019 0.023 0.0543
Trypanosoma brucei trypanothione reductase 0.0051 0.0803 0.2549
Schistosoma mansoni smad1 5 8 and 0.001 0.0061 0.0193
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0105 0.0229
Brugia malayi diaphorase 0.0019 0.023 0.0726
Echinococcus multilocularis GPCR, family 2 0.0019 0.0229 0.0229
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0543
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0046
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0202 0.0445
Loa Loa (eye worm) guanylate kinase 0.0007 0.0015 0.0046
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0105 0.0329
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0105 0.0331
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0168 0.2933 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0105 0.0329
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0019 0.023 0.0543
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0105 0.0105
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0105 0.0331
Schistosoma mansoni cell polarity protein 0.0007 0.0015 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1367 0.4522
Schistosoma mansoni sap-97 0.0007 0.0015 0.0046
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0019 0.023 0.1174
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0543
Brugia malayi Patj homolog 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Loa Loa (eye worm) PAR-6 protein 0.0007 0.0015 0.0046
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0105 0.0329
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0074 0.0235
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0543
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0007 0.0015 0.0015
Echinococcus multilocularis multiple pdz domain protein 0.0007 0.0015 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0258 0.0644
Mycobacterium ulcerans oxidoreductase 0.0019 0.023 0.0543
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0105 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0105 0.0106
Brugia malayi Bromodomain containing protein 0.0046 0.0723 0.2288
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0007 0.0015 0.0015
Schistosoma mansoni amyloid beta A4 protein related 0.0007 0.0015 0.0046
Schistosoma mansoni MAGUK homolog 0.0007 0.0015 0.0046
Giardia lamblia Nitric oxide synthase, inducible 0.0149 0.2586 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0202 0.0445
Schistosoma mansoni hypothetical protein 0.0012 0.0105 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1367 0.4522
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1367 0.4522
Entamoeba histolytica hypothetical protein 0.0039 0.0583 0.5214
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0168 0.2933 1
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0543
Brugia malayi gopc protein 0.0007 0.0015 0.0046
Schistosoma mansoni syntrophin 0.0007 0.0015 0.0046
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.019 0.019
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0105 0.0329
Loa Loa (eye worm) hypothetical protein 0.0011 0.0074 0.0235
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.019 0.0405
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0105 0.0105
Mycobacterium ulcerans monooxygenase 0.0019 0.023 0.0543
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0046
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0803 0.0803
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0019 0.023 0.0543
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Brugia malayi syntenin 0.0007 0.0015 0.0046
Echinococcus granulosus smad 0.001 0.0061 0.0061
Brugia malayi CHD4 protein 0.0015 0.0147 0.0464
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0019 0.023 0.0194
Plasmodium falciparum glutathione reductase 0.0051 0.0803 0.2549
Schistosoma mansoni dishevelled 0.0007 0.0015 0.0046
Echinococcus granulosus Partitioning defective 3 protein B 0.0007 0.0015 0.0015
Brugia malayi Syntrophin-1 0.0007 0.0015 0.0046
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0105 0.0106
Echinococcus multilocularis pdz domain containing protein 0.0007 0.0015 0.0015
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0168 0.2933 0.2933
Echinococcus granulosus chromobox protein 2 0.0012 0.0105 0.0105
Brugia malayi hypothetical protein 0.0011 0.0074 0.0235
Echinococcus multilocularis rho guanine nucleotide exchange factor 12 0.0007 0.0015 0.0015
Entamoeba histolytica type A flavoprotein, putative 0.0064 0.105 1
Brugia malayi hypothetical protein 0.0148 0.2571 0.8135
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0105 0.0105
Echinococcus multilocularis geminin 0.0181 0.318 0.318
Brugia malayi Smad1 0.001 0.0061 0.0194
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0202 0.0507
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Schistosoma mansoni DNA helicase recq1 0.0011 0.0076 0.0238
Schistosoma mansoni topbp1 0.0011 0.0074 0.0234
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0202 0.0445
Brugia malayi 9ORF binding protein 1 0.0007 0.0015 0.0046
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0076 0.0239
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0064 0.105 0.3411
Schistosoma mansoni sh3 and multiple ankyrin repeat domains protein 12 (shank12) 0.0007 0.0015 0.0046
Brugia malayi RasGEF domain containing protein 0.0007 0.0015 0.0046
Plasmodium falciparum thioredoxin reductase 0.0018 0.0202 0.0445
Loa Loa (eye worm) hypothetical protein 0.0021 0.0257 0.0813
Onchocerca volvulus 0.0012 0.0105 0.0353
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0258 0.0644
Trichomonas vaginalis chromobox protein, putative 0.0075 0.1239 0.4072
Schistosoma mansoni ATP-dependent RNA Helicase 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0996 0.3224
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Loa Loa (eye worm) cell junction protein LIN-7 0.0007 0.0015 0.0046
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0007 0.0015 0.0015
Treponema pallidum ferredoxin-NADP(+) reductase subunit alpha 0.0019 0.023 0.1591
Onchocerca volvulus 0.0012 0.0105 0.0352
Brugia malayi hypothetical protein 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0011 0.0074 0.0235
Schistosoma mansoni chromobox protein 0.0075 0.1239 0.3895
Schistosoma mansoni hypothetical protein 0.0181 0.318 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0007 0.0015 0.0015
Schistosoma mansoni discs lost-related 0.0007 0.0015 0.0046
Echinococcus multilocularis myeloid:lymphoid or mixed lineage leukemia 0.0007 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0039 0.0583 0.5214
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0105 0.0106
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0202 0.0445
Echinococcus granulosus partitioning defective 3 0.0007 0.0015 0.0015
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0252 0.0791
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.019 0.0876
Loa Loa (eye worm) hypothetical protein 0.0129 0.2234 0.7069
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0258 0.0812
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0105 0.0329
Echinococcus multilocularis microtubule associated serine:threonine protein 0.0007 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0074 0.0235
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0105 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0105 0.0331
Brugia malayi hypothetical protein 0.0039 0.0583 0.1844
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0007 0.0015 0.0015
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0257 0.0257
Schistosoma mansoni cell polarity protein 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0007 0.0015 0.0015
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0887 0.2805
Echinococcus multilocularis Na(+):H(+) exchange regulatory cofactor NHE RF2 0.0007 0.0015 0.0015
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.019 0.0876
Brugia malayi PDZ domain containing protein 0.0007 0.0015 0.0046
Onchocerca volvulus 0.0019 0.023 0.0841
Loa Loa (eye worm) AGC/MAST/MAST protein kinase 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Echinococcus multilocularis glutamate receptor interacting protein 1 0.0007 0.0015 0.0015
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0803 0.2549
Echinococcus granulosus beta 1 syntrophin 0.0007 0.0015 0.0015
Echinococcus granulosus multiple pdz domain protein 0.0007 0.0015 0.0015
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0105 0.0106
Echinococcus multilocularis zinc finger protein 0.0024 0.0312 0.0312
Loa Loa (eye worm) PDZ domain-containing protein 0.0007 0.0015 0.0046
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.019 0.0405
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0202 0.0202
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0583 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0105 0.0331
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0977 0.309
Echinococcus granulosus pdz domain containing protein 0.0007 0.0015 0.0015
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0258 0.0336
Schistosoma mansoni leucine-rich repeat protein 0.0007 0.0015 0.0046
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Echinococcus granulosus geminin 0.0181 0.318 0.318
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0258 0.0644
Echinococcus multilocularis pdz domain containing protein 0.0007 0.0015 0.0015
Echinococcus granulosus muscleblind protein 0.018 0.3161 0.3161
Treponema pallidum NADH oxidase 0.0018 0.0202 0.1305
Schistosoma mansoni lim domain 0.0007 0.0015 0.0046
Trypanosoma cruzi ISWI complex protein 0.0018 0.0219 0.0504
Trypanosoma brucei unspecified product 0.0021 0.0258 0.0644
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0258 0.0258
Brugia malayi SET domain containing protein 0.0012 0.0105 0.0331
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0019 0.023 0.0722
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.002 0.0254 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0105 0.0331
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.035 0.0964
Brugia malayi gamma-syntrophin-like protein SYN2 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0041 0.0631 0.1995
Onchocerca volvulus Huntingtin homolog 0.0148 0.2571 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Mycobacterium tuberculosis Probable reductase 0.0116 0.1982 0.8844
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0105 0.0331
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0019 0.023 0.0543
Loa Loa (eye worm) hypothetical protein 0.0033 0.0479 0.1514
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0105 0.0105
Trichomonas vaginalis hypothetical protein 0.0012 0.0105 0.0106
Entamoeba histolytica hypothetical protein 0.0012 0.0105 0.0311
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0132 0.0595
Brugia malayi interleukin-16 0.0007 0.0015 0.0046
Leishmania major DNA polymerase eta, putative 0.0048 0.0754 0.222
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0421 0.1212
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0671 0.0671
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0064 0.105 0.3411
Onchocerca volvulus Huntingtin homolog 0.0148 0.2571 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0202 0.0445
Entamoeba histolytica type A flavoprotein, putative 0.0064 0.105 1
Schistosoma mansoni multiple pdz domain protein 0.0007 0.0015 0.0046
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0168 0.2933 1
Toxoplasma gondii thioredoxin reductase 0.0051 0.0803 0.5511
Echinococcus multilocularis disks large 3 0.0007 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.018 0.3161 1
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0202 0.0963
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0142 0.0236
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0202 0.0247
Echinococcus granulosus pdz domain containing protein 0.0007 0.0015 0.0015
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0258 0.0644
Schistosoma mansoni maguk P55 subfamily member 26 0.0007 0.0015 0.0046
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0105 0.0352
Echinococcus multilocularis multiple pdz domain protein 0.0007 0.0015 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0258 0.0644
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Echinococcus multilocularis segment polarity protein dishevelled 0.0007 0.0015 0.0015
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0007 0.0015 0.0046
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.019 0.0598
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0074 0.0074
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.039 0.2384
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0105 0.0331
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0019 0.023 0.0543
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0117 0.037
Loa Loa (eye worm) guanylate kinase 0.0007 0.0015 0.0046
Schistosoma mansoni hypothetical protein 0.0039 0.0583 0.1833
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Trypanosoma brucei ISWI complex protein 0.0018 0.0219 0.0504
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0149 0.2586 0.8787
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0105 0.0106
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0105 0.0331
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0007 0.0015 0.0015
Brugia malayi steroid hormone receptor 0.0012 0.0105 0.0331
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0105 0.0331
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0105 0.0352
Leishmania major NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0347
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0202 0.0247
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0202 0.0445
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0105 0.0106
Brugia malayi flavodoxin family protein 0.0064 0.105 0.3321
Echinococcus granulosus pdz domain containing protein 0.0007 0.0015 0.0015
Schistosoma mansoni smad 0.001 0.0061 0.0193
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0007 0.0015 0.0015
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0019 0.023 0.0543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0105 0.0331
Echinococcus multilocularis smad 0.001 0.0061 0.0061
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0105 0.0105
Echinococcus granulosus segment polarity protein dishevelled 0.0007 0.0015 0.0015
Echinococcus multilocularis partitioning defective 3 0.0007 0.0015 0.0015
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0105 0.0105
Chlamydia trachomatis DNA ligase 0.0011 0.0074 0.0341
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0076 0.0076
Echinococcus multilocularis disks large 1 0.0007 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Loa Loa (eye worm) FAD binding domain-containing protein 0.0168 0.2933 0.928
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0105 0.0105
Brugia malayi chromobox protein homolog 3 0.0042 0.0643 0.2034
Plasmodium vivax glutathione reductase, putative 0.0051 0.0803 0.2549
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0202 0.0445
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.019 0.019
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0105 0.0106
Echinococcus multilocularis cell polarity protein leucine rich repeat 0.0007 0.0015 0.0015
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0202 0.0445
Plasmodium falciparum ferredoxin--NADP reductase 0.0019 0.023 0.0543
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0543
Schistosoma mansoni coup transcription factor 0.0012 0.0105 0.0329
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0061 0.0194
Schistosoma mansoni MAGUK homolog 0.0007 0.0015 0.0046
Leishmania major cytochrome-b5 reductase, putative 0.0019 0.023 0.0347
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.2216 1
Brugia malayi Bromodomain containing protein 0.0091 0.1529 0.4836
Brugia malayi Protein-tyrosine phosphatase 1 0.0007 0.0015 0.0046
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0061 0.0193
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.035 0.1107
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0258 0.0644
Brugia malayi hypothetical protein 0.0007 0.0015 0.0046
Echinococcus granulosus Chromobox protein 3 0.0012 0.0105 0.0105
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0019 0.023 0.0726
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0082 0.1367 0.4522
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0643 0.1988
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.019 0.019
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0168 0.2933 1
Echinococcus multilocularis beta 1 syntrophin 0.0007 0.0015 0.0015
Leishmania major reductase, putative 0.0019 0.023 0.0347
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0105 0.0105
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0202 0.0445
Brugia malayi Partitioning defective-6 homolog alpha 0.0007 0.0015 0.0046
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0147 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0105 0.0331
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0019 0.023 0.0543
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0007 0.0015 0.0015
Brugia malayi flavodoxin family protein 0.0168 0.2933 0.928
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0887 0.2788
Plasmodium falciparum glutathione reductase 0.0018 0.0202 0.0445
Entamoeba histolytica Flap nuclease, putative 0.0028 0.039 0.3232
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0336 0.1062
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0147 0.0461
Brugia malayi Isocitrate dehydrogenase 0.0017 0.019 0.0602
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0543
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0257 0.0257
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0082 0.1367 0.4522
Brugia malayi MH2 domain containing protein 0.001 0.0061 0.0194
Toxoplasma gondii flavodoxin domain-containing protein 0.0083 0.1396 1
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0064 0.105 0.3411
Entamoeba histolytica hypothetical protein 0.0012 0.0105 0.0311
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0557 1 1
Echinococcus granulosus tight junction protein ZO 3 0.0007 0.0015 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0105 0.0105
Brugia malayi Protein cec-1. 0.0012 0.0105 0.0331
Schistosoma mansoni cell polarity protein 0.0007 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Loa Loa (eye worm) gopc protein 0.0007 0.0015 0.0046
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0258 0.0258
Trypanosoma cruzi p450 reductase, putative 0.0168 0.2933 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0076 0.0239
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Schistosoma mansoni chromobox protein 0.0012 0.0105 0.0329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0887 0.2788
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0132 0.0203
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.019 0.0405
Plasmodium falciparum nitric oxide synthase, putative 0.0168 0.2933 1
Schistosoma mansoni cytochrome P450 reductase 0.0168 0.2933 0.9223
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0105 0.0105
Echinococcus granulosus zinc finger protein 0.0024 0.0312 0.0312
Brugia malayi isocitrate dehydrogenase 0.0017 0.019 0.0602
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0046
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.019 0.0405
Brugia malayi PDZ-domain protein scribble 0.0007 0.0015 0.0046
Schistosoma mansoni zinc finger protein 0.0024 0.0312 0.0982
Schistosoma mansoni smad1 5 8 and 0.001 0.0061 0.0193
Brugia malayi DKFZp564C0469 protein 0.0011 0.0074 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0258 0.0644
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0105 0.0331
Brugia malayi Shank2E 0.0007 0.0015 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0105 0.0106
Leishmania major NADH-dependent fumarate reductase-like protein 0.0019 0.023 0.0347
Brugia malayi Thioredoxin reductase 0.0051 0.0803 0.254
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0105 0.0106
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0104 0.1766 0.5554
Echinococcus granulosus cell polarity protein 0.0007 0.0015 0.0015
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Echinococcus multilocularis multiple pdz domain protein 0.0007 0.0015 0.0015
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.019 0.0207
Brugia malayi Synapse defective protein 1 0.0007 0.0015 0.0046
Loa Loa (eye worm) 9ORF binding protein 1 0.0007 0.0015 0.0046
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.019 0.0405
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0007 0.0015 0.0046
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0229 0.0724
Echinococcus granulosus dna polymerase eta 0.0048 0.0754 0.0754
Leishmania major cytochrome-b5 reductase, putative 0.0019 0.023 0.0347
Plasmodium falciparum flap endonuclease 1 0.0028 0.039 0.1102
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0258 0.0644
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.039 0.1102
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0105 0.0106
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0105 0.0105
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0168 0.2933 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0258 0.0817
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1367 0.4522
Brugia malayi hypothetical protein 0.0007 0.0015 0.0046
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0046
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.002 0.0254 0.0627
Leishmania major DNA polymerase kappa, putative 0.0021 0.0258 0.045
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.1982 0.8844
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.039 0.0918
Trichomonas vaginalis chromobox protein, putative 0.0045 0.07 0.219
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0105 0.0106
Echinococcus granulosus nibrin 0.0011 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0105 0.0331
Giardia lamblia Flavohemoprotein lateral transfer candidate 0.0019 0.023 0.0618
Loa Loa (eye worm) hypothetical protein 0.0019 0.0229 0.0724
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0168 0.2933 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0258 0.0644
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0019 0.023 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0254 0.0627
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Chlamydia trachomatis sulfite reductase 0.0104 0.1766 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0202 0.0056
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0105 0.0229
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0007 0.0015 0.0015
Leishmania major DNA polymerase eta, putative 0.0034 0.0495 0.1295
Brugia malayi MH1 domain containing protein 0.001 0.0061 0.0194
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0229 0.0724
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.2216 1
Trichomonas vaginalis chromobox protein, putative 0.0075 0.1239 0.4072
Schistosoma mansoni leucine-rich repeat protein 0.0007 0.0015 0.0046
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.0754 0.2386
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.1239 0.3919
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Schistosoma mansoni discs large 0.0007 0.0015 0.0046
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.019 0.0602
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0254 0.0627
Echinococcus multilocularis bloom syndrome protein 0.0026 0.035 0.035
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2502 0.7918
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0168 0.2933 0.2933
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0258 0.0817
Entamoeba histolytica hypothetical protein 0.0039 0.0583 0.5214
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0105 0.0329
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0202 1
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1367 0.4522
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.1982 0.8844
Loa Loa (eye worm) flavodoxin family protein 0.0064 0.105 0.3321
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0019 0.023 0.0194
Schistosoma mansoni topbp1 0.0011 0.0074 0.0234
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0803 0.3025
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0229 0.0724
Brugia malayi Abnormal embryonic partitioning of cytoplasm protein 3 0.0007 0.0015 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0105 0.0331
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0258 0.0644
Echinococcus multilocularis MAGUK p55 subfamily 0.0007 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1367 0.4522
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0019 0.023 0.0543
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0229 0.0229
Echinococcus granulosus Rho GTPase activating protein 21 0.0007 0.0015 0.0015
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0105 0.0331
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0105 0.0105
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0168 0.2933 0.2933
Trypanosoma cruzi p450 reductase, putative 0.0019 0.023 0.0543
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0076 0.0009
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.002 0.0254 0.0627
Brugia malayi DIX domain containing protein 0.0007 0.0015 0.0046
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0258 0.0336
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0202 0.0445
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Trypanosoma brucei unspecified product 0.0014 0.0142 0.0236
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0007 0.0015 0.0015
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.039 0.1255
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0202 0.1068
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0105 0.0106
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Brugia malayi Peripheral plasma membrane protein CASK 0.0007 0.0015 0.0046
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0202 0.0445
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0019 0.023 0.0543
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0258 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0105 0.0106
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0229 0.0229
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0202 0.0445
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0257 0.0808
Schistosoma mansoni bromodomain containing protein 0.0076 0.1271 0.3998
Giardia lamblia NADPH oxidoreductase, putative 0.0082 0.1367 0.5146
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0019 0.023 0.0543
Echinococcus granulosus Na:H exchange regulatory cofactor NHE RF2 0.0007 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0046
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0132 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0105 0.0331
Echinococcus multilocularis partitioning defective protein 6 0.0007 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0258 0.0644
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0202 0.0445
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0076 0.0076
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0168 0.2933 0.2933
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0105 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1367 0.4522
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0061 0.0061
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0258 0.0644
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0254 0.0627
Schistosoma mansoni protein kinase C alpha binding protein 0.0007 0.0015 0.0046
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0019 0.023 0.0543
Echinococcus granulosus multiple pdz domain protein 0.0007 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1367 0.4522
Schistosoma mansoni hypothetical protein 0.0025 0.0336 0.1055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0257 0.0808
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0631 0.1995
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1367 0.4522
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0007 0.0015 0.0046
Brugia malayi cell junction protein LIN-7 0.0007 0.0015 0.0046
Echinococcus multilocularis neurabin 1 0.0007 0.0015 0.0015

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 8.9125 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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