Detailed information for compound 1418080

Basic information

Technical information
  • TDR Targets ID: 1418080
  • Name: 4-(4-methylphenyl)sulfonylbut-2-ynyl 4-nitrob enzoate
  • MW: 373.38 | Formula: C18H15NO6S
  • H donors: 0 H acceptors: 5 LogP: 2.96 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)CC#CCOC(=O)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C18H15NO6S/c1-14-4-10-17(11-5-14)26(23,24)13-3-2-12-25-18(20)15-6-8-16(9-7-15)19(21)22/h4-11H,12-13H2,1H3
  • InChiKey: XFUYNASYVIGKBI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-nitrobenzoic acid 4-(4-methylphenyl)sulfonylbut-2-ynyl ester
  • EU-0001757
  • 4-[(4-methylphenyl)sulfonyl]-2-butyn-1-yl 4-nitrobenzoate
  • MLS000534068
  • SMR000141506
  • ZINC02891850
  • STK072208

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus DNA-damage inducible transcript 3 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens X-box binding protein 1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134980 All targets in OG5_134980
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major pyruvate kinase 0.004 0.0426 0.041
Plasmodium vivax pyruvate kinase, putative 0.004 0.0426 0.336
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0233 0.3547 0.5002
Loa Loa (eye worm) hypothetical protein 0.004 0.0426 0.0424
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1332 0.133
Plasmodium falciparum thioredoxin reductase 0.0092 0.1262 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0043 0.0465 0.0422
Brugia malayi hypothetical protein 0.0019 0.0082 0.0079
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0946 0.0931
Schistosoma mansoni rab6-interacting 0.0024 0.0159 0.0157
Entamoeba histolytica cysteine proteinase 1, putative 0.0022 0.013 0.0259
Trypanosoma cruzi cysteine protease, putative 0.0022 0.013 0.0127
Brugia malayi follicle stimulating hormone receptor 0.0232 0.3523 0.3522
Onchocerca volvulus 0.007 0.0911 0.1919
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0465 0.083
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0426 0.0384
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.068 0.0678
Schistosoma mansoni cathepsin F (C01 family) 0.0043 0.0465 0.0462
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0426 0.0423
Schistosoma mansoni hypothetical protein 0.0348 0.5401 0.54
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1383 0.1369
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0079
Echinococcus multilocularis thioredoxin glutathione reductase 0.0093 0.1272 0.1233
Plasmodium vivax SET domain protein, putative 0.0036 0.0357 0.2817
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0465 0.083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0082 0.0038
Mycobacterium ulcerans beta-lactamase 0.007 0.0911 0.9421
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.029 0.2281
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0426 0.0424
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0413 0.0397
Onchocerca volvulus Cathepsin F homolog 0.0043 0.0465 0.0886
Toxoplasma gondii ABC1 family protein 0.007 0.0911 0.0911
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2603 0.5812
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1383 0.1369
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.012 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0426 0.0424
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0632 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.013 0.0127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1383 0.1369
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0426 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0465 0.083
Echinococcus granulosus cysteine protease 0.0022 0.013 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2458 0.5476
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0056 0.0011
Schistosoma mansoni loxhd1 0.0024 0.0159 0.0157
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0426 0.0384
Brugia malayi nuclear hormone receptor 0.004 0.0426 0.0424
Schistosoma mansoni thyroid hormone receptor 0.0164 0.2421 0.2419
Loa Loa (eye worm) hypothetical protein 0.0021 0.0119 0.0116
Loa Loa (eye worm) hypothetical protein 0.0029 0.0236 0.0234
Schistosoma mansoni hypothetical protein 0.002 0.0101 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0465 0.083
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0043 0.0465 0.083
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0291 0.0289
Brugia malayi Cathepsin L-like precursor 0.0043 0.0465 0.0462
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.096 0.096
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0627 0.0586
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0082 0.0038
Loa Loa (eye worm) hypothetical protein 0.007 0.0911 0.0909
Loa Loa (eye worm) hypothetical protein 0.004 0.0426 0.0423
Loa Loa (eye worm) hypothetical protein 0.0042 0.045 0.0447
Onchocerca volvulus 0.0043 0.0465 0.0886
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1768 0.1732
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0079
Onchocerca volvulus Cathepsin L homolog 0.0043 0.0465 0.0886
Giardia lamblia Pyruvate kinase 0.0021 0.0109 0.0015
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0413 0.0371
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0426 0.0424
Plasmodium vivax thioredoxin reductase, putative 0.0092 0.1262 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0465 0.083
Loa Loa (eye worm) hypothetical protein 0.0027 0.0211 0.0209
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1332 0.1293
Schistosoma mansoni lipoxygenase 0.0142 0.2078 0.2076
Brugia malayi cytochrome P450 0.0021 0.012 0.0117
Plasmodium vivax vivapain-2 0.0043 0.0465 0.3669
Plasmodium falciparum glutathione reductase 0.0032 0.029 0.194
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.0465 0.0462
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0426 0.0424
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0911 0.1225
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.3865 0.8753
Schistosoma mansoni lamin 0.0056 0.068 0.0678
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1332 0.1293
Mycobacterium tuberculosis Probable dehydrogenase 0.021 0.3168 0.4459
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.3865 0.8753
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.012 0.0137
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1768 0.1732
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0082 0.0079
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0082 0.0038
Plasmodium vivax glutathione reductase, putative 0.0092 0.1262 1
Echinococcus granulosus pyruvate kinase 0.0021 0.0109 0.0065
Onchocerca volvulus 0.007 0.0911 0.1919
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0413 0.0711
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0159 0.0115
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0911 0.1225
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0056 0.0011
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0211 0.0168
Echinococcus multilocularis X box binding protein 1 0.0348 0.5401 0.5381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0465 0.083
Schistosoma mansoni nuclear receptor 0.0019 0.0082 0.0079
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0426 0.0424
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.012 0.0092
Mycobacterium tuberculosis Conserved protein 0.007 0.0911 0.1225
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.029 0.2132
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0946 0.0931
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0426 0.0424
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0159 0.0115
Entamoeba histolytica cysteine proteinase 2 0.0022 0.013 0.0259
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0426 0.0424
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0413 0.0411
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0426 0.0424
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0291 0.0289
Toxoplasma gondii fructose-bisphospatase II 0.0632 1 1
Brugia malayi Cathepsin L-like precursor 0.0043 0.0465 0.0462
Mycobacterium leprae conserved hypothetical protein 0.007 0.0911 0.2308
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.012 0.012
Echinococcus multilocularis zinc finger protein 0.0019 0.0084 0.004
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0211 0.0168
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0413 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0426 0.0384
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0054 0.0052
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0056 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.029 0.0287
Entamoeba histolytica cysteine protease, putative 0.0022 0.013 0.0259
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0627 0.0625
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0413 0.0711
Loa Loa (eye worm) hypothetical protein 0.0029 0.0236 0.0234
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.012 0.0103
Schistosoma mansoni hypothetical protein 0.0015 0.0016 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.0043 0.0465 0.4253
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0109 0.0438
Echinococcus multilocularis lamin 0.0056 0.068 0.0639
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.012 0.0092
Loa Loa (eye worm) pyruvate kinase 0.004 0.0426 0.0423
Mycobacterium ulcerans pyruvate kinase 0.004 0.0426 0.3728
Loa Loa (eye worm) hypothetical protein 0.0043 0.0465 0.0462
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.012 0.0092
Loa Loa (eye worm) hypothetical protein 0.0029 0.0236 0.0234
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0082 0.0038
Loa Loa (eye worm) pyruvate kinase 0.004 0.0426 0.0423
Echinococcus granulosus pyruvate kinase 0.004 0.0426 0.0383
Loa Loa (eye worm) hypothetical protein 0.004 0.0419 0.0417
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2458 0.5476
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.012 0.0137
Echinococcus multilocularis geminin 0.0352 0.5467 0.5447
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0946 0.0944
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.1332 0.133
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.029 0.572
Schistosoma mansoni zinc finger protein 0.0015 0.0016 0.0014
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.012 0.0137
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0946 0.0944
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0082 0.0038
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.029 0.194
Brugia malayi Cathepsin L-like precursor 0.0043 0.0465 0.0462
Loa Loa (eye worm) hypothetical protein 0.018 0.2692 0.269
Schistosoma mansoni inositol monophosphatase 0.004 0.0413 0.0411
Brugia malayi Cathepsin L-like precursor 0.0029 0.0236 0.0234
Giardia lamblia Pyruvate kinase 0.004 0.0426 1
Schistosoma mansoni cathepsin F (C01 family) 0.0043 0.0465 0.0462
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0003 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1332 0.1293
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0426 0.0798
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0159 0.0115
Schistosoma mansoni hypothetical protein 0.0123 0.1768 0.1767
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0108 0.0106
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.029 0.0287
Plasmodium falciparum thioredoxin reductase 0.0032 0.029 0.194
Schistosoma mansoni zinc finger protein 0.0019 0.0084 0.0082
Echinococcus multilocularis muscleblind protein 0.018 0.2692 0.2659
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0946 0.0944
Echinococcus granulosus zinc finger protein 0.0019 0.0084 0.004
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0426 0.0796
Entamoeba histolytica cysteine protease, putative 0.0022 0.013 0.0259
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0112 0.001
Mycobacterium tuberculosis Probable oxidoreductase 0.0233 0.3547 0.5002
Echinococcus multilocularis cathepsin L 0.0022 0.013 0.0086
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.021 0.3168 0.8895
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.013 0.0113
Onchocerca volvulus 0.0043 0.0465 0.0886
Onchocerca volvulus 0.0043 0.0465 0.0886
Loa Loa (eye worm) hypothetical protein 0.0069 0.0894 0.0892
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0079
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.012 0.0092
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0159 0.1245
Brugia malayi Pre-SET motif family protein 0.0251 0.3839 0.3837
Onchocerca volvulus 0.0036 0.0357 0.0638
Loa Loa (eye worm) cytochrome P450 0.0021 0.012 0.0117
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.029 0.0287
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0229 0.0226
Echinococcus granulosus geminin 0.0352 0.5467 0.5447
Leishmania major cysteine peptidase A (CPA) 0.0043 0.0465 0.0449
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.029 0.0274
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.029 0.0287
Trypanosoma brucei pyruvate kinase 1 0.004 0.0426 0.041
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0159 0.0157
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.029 0.0274
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0426 0.0424
Echinococcus granulosus cathepsin L cysteine proteinase 0.0043 0.0465 0.0422
Loa Loa (eye worm) hypothetical protein 0.004 0.0426 0.0424
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0426 0.0424
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0079
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0044 0.0042
Echinococcus multilocularis pyruvate kinase 0.004 0.0426 0.0383
Leishmania major cathepsin L-like protease 0.0043 0.0465 0.0449
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.029 0.029
Echinococcus multilocularis RUN 0.0024 0.0159 0.0115
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0413 0.3642
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0627 0.0625
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.1262 0.126
Entamoeba histolytica cysteine protease, putative 0.0022 0.013 0.0259
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.012 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.013 0.0113
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.3865 0.8753
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0911 0.9421
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0911 0.0909
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0426 0.0424
Brugia malayi Cathepsin L-like precursor 0.0043 0.0465 0.0462
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.013 0.0127
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.012 0.0117
Leishmania major cathepsin L-like protease 0.0043 0.0465 0.0449
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0465 0.083
Trypanosoma cruzi ISWI complex protein 0.0015 0.0016 0.0014
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0911 0.1225
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0119 0.0116
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0108 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0236 0.0299
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0426 0.0423
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0357 0.0355
Echinococcus granulosus X box binding protein 1 0.0348 0.5401 0.5381
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0131 0.0087
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0108 0.0106
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0233 0.3547 0.5002
Echinococcus granulosus bloom syndrome protein 0.0021 0.0112 0.0068
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0291 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0465 0.083
Schistosoma mansoni hypothetical protein 0.0024 0.0159 0.0157
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.012 0.0137
Echinococcus multilocularis pyruvate kinase 0.004 0.0426 0.0383
Echinococcus multilocularis musashi 0.0056 0.068 0.0639
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0632 1 1
Schistosoma mansoni hypothetical protein 0.0021 0.012 0.0117
Trypanosoma brucei trypanothione reductase 0.0092 0.1262 0.1248
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0426 0.0426
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0426 0.0384
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0044 0.0042
Schistosoma mansoni pyruvate kinase 0.0021 0.0109 0.0106
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.029 0.0423
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.012 0.0092
Loa Loa (eye worm) hypothetical protein 0.004 0.0426 0.0424
Leishmania major cathepsin L-like protease 0.0043 0.0465 0.0449
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0426 0.0424
Leishmania major 0.0632 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.096 1
Leishmania major cytochrome p450-like protein 0.0032 0.0291 0.0275
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0082 0.0079
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.029 0.2132
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0426 0.0796
Entamoeba histolytica cysteine protease, putative 0.0022 0.013 0.0259
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0465 0.083
Trichomonas vaginalis esterase, putative 0.007 0.0911 0.187
Onchocerca volvulus 0.0056 0.068 0.1386
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0108 0.0092
Echinococcus granulosus pyruvate kinase 0.004 0.0426 0.0383
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.029 0.0274
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.012 0.0092
Brugia malayi nuclear receptor NHR-88 0.004 0.0426 0.0424
Mycobacterium tuberculosis Conserved protein 0.007 0.0911 0.1225
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.012 0.0137
Echinococcus granulosus lamin dm0 0.0056 0.068 0.0639
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.096 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2458 0.5476
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0153 0.0151
Onchocerca volvulus Cathepsin L homolog 0.0043 0.0465 0.0886
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0343 0.03
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0632 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.013 0.0259
Loa Loa (eye worm) hypothetical protein 0.007 0.0911 0.0909
Leishmania major cathepsin L-like protease 0.0043 0.0465 0.0449
Plasmodium falciparum glutathione reductase 0.0092 0.1262 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0911 0.0909
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.3865 0.8753
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0426 0.074
Loa Loa (eye worm) hypothetical protein 0.0024 0.0159 0.0157
Echinococcus multilocularis pyruvate kinase 0.0021 0.0109 0.0065
Brugia malayi hypothetical protein 0.0021 0.0119 0.0116
Loa Loa (eye worm) hypothetical protein 0.0021 0.0119 0.0116
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0259 0.0257
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0056 0.0053
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.029 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0426 0.0424
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0079
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0627 0.0586
Mycobacterium tuberculosis Probable reductase 0.021 0.3168 0.4459
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0413 0.0411
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0911 0.087
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.021 0.3168 0.4459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1383 0.1369
Onchocerca volvulus 0.0167 0.2467 0.5523
Entamoeba histolytica cysteine protease, putative 0.0022 0.013 0.0259
Plasmodium falciparum pyruvate kinase 0.004 0.0426 0.3067
Echinococcus granulosus thioredoxin glutathione reductase 0.0093 0.1272 0.1233
Leishmania major cytochrome p450-like protein 0.0021 0.012 0.0103
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0056 0.0011
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0056 0.0011
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0235 0.3577 0.3577
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0291 0.0275
Schistosoma mansoni inositol monophosphatase 0.004 0.0413 0.0411
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0336 0.0293
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0426 0.0384
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.012 0.0092
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.029 0.0274
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0291 0.2145
Loa Loa (eye worm) fibroinase 0.0043 0.0465 0.0462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0465 0.083
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.012 0.0137
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0043 0.0465 0.0462
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.012 0.0137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0465 0.083
Trypanosoma cruzi cysteine proteinase, putative 0.0022 0.013 0.0127
Brugia malayi hypothetical protein 0.0019 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.007 0.0911 0.0909
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.012 0.0117
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.029 0.0287
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.2078 0.2042
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.012 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0426 0.0424
Schistosoma mansoni cytochrome P450 0.0021 0.012 0.0117
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0413 0.0413
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0043 0.0465 0.083
Schistosoma mansoni hypothetical protein 0.0352 0.5467 0.5466
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.012 0.0137
Loa Loa (eye worm) hypothetical protein 0.004 0.0426 0.0424
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0119 0.0116
Brugia malayi Thioredoxin reductase 0.0092 0.1262 0.126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0465 0.083
Leishmania major trypanothione reductase 0.0092 0.1262 0.1248
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.029 0.0287
Entamoeba histolytica cysteine protease, putative 0.0022 0.013 0.0259
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0426 0.0384
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0865 0.0863
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0159 0.0858
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0043 0.0465 0.0462
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0236 0.153
Schistosoma mansoni rab6-interacting 0.0024 0.0159 0.0157
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0235 0.3577 0.3566
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0041 0.0039
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.012 0.0137
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0426 0.0424
Trypanosoma cruzi cruzipain precursor, putative 0.01 0.1383 0.1381
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.012 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0426 0.0424
Schistosoma mansoni hypothetical protein 0.0057 0.0696 0.0694
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.029 0.2281
Brugia malayi hypothetical protein 0.0024 0.0159 0.0157
Schistosoma mansoni cathepsin F (C01 family) 0.0029 0.0236 0.0234
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0426 0.0423
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.013 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0426 0.0424
Echinococcus granulosus RUN 0.0024 0.0159 0.0115
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0426 0.0798
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.013 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0465 0.083
Brugia malayi conserved hypotetical protein 0.0019 0.0082 0.0079
Brugia malayi steroid hormone receptor 0.004 0.0426 0.0424
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0056 0.0011
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.012 0.0137
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0911 0.0909
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0109 0.0843
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.029 0.0335
Brugia malayi Cytochrome P450 family protein 0.0067 0.0865 0.0863
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0453 0.041
Toxoplasma gondii thioredoxin reductase 0.0092 0.1262 0.1262
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0109 0.0109
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0056 0.0053
Leishmania major cathepsin L-like protease 0.01 0.1383 0.1369
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0911 0.187
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0426 0.0424
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0082 0.0038
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.021 0.3168 0.4459
Schistosoma mansoni lamin 0.0056 0.068 0.0678
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.1332 0.133
Brugia malayi Doublecortin family protein 0.0024 0.0159 0.0157
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.3839 0.3837
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.021 0.3168 0.4459
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0082 0.0079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.096 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0092 0.1262 0.1728
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0291 0.0289
Brugia malayi Cathepsin L-like precursor 0.0043 0.0465 0.0462
Onchocerca volvulus 0.0056 0.068 0.1386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0465 0.083
Brugia malayi cathepsin L-like precursor 0.0029 0.0236 0.0234
Brugia malayi nuclear receptor RXR 0.0021 0.0119 0.0116
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0108 0.0434
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1332 0.133
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0426 0.0424
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0119 0.0075
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.012 0.0076
Onchocerca volvulus 0.0024 0.0159 0.0179
Brugia malayi Cathepsin L-like cysteine proteinase 0.0029 0.0236 0.0234
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.012 0.0137
Mycobacterium ulcerans hypothetical protein 0.007 0.0911 0.9421
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0426 0.0384
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0082 0.0079
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.012 0.0137
Brugia malayi Cytochrome P450 family protein 0.0032 0.0291 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0465 0.083
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0119 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0465 0.083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1383 0.1369
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.018 0.2692 0.269
Plasmodium vivax vivapain-3 0.0022 0.013 0.1011
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0056 0.0053
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.012 0.0092
Leishmania major cathepsin L-like protease 0.0043 0.0465 0.0449
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0426 0.041
Plasmodium vivax vivapain-1 0.0022 0.013 0.1011
Brugia malayi ecdysteroid receptor 0.004 0.0426 0.0424
Chlamydia trachomatis pyruvate kinase 0.004 0.0426 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0082 0.0079
Brugia malayi Pre-SET motif family protein 0.0036 0.0357 0.0355
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0946 0.0944
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0108 0.0064
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.029 0.0274
Brugia malayi Cathepsin L-like precursor 0.0029 0.0236 0.0234
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0357 0.0355
Loa Loa (eye worm) hypothetical protein 0.0021 0.0119 0.0116
Brugia malayi intermediate filament protein 0.0056 0.068 0.0678
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0043 0.0465 0.3389
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1332 0.1293
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0108 0.0075
Onchocerca volvulus 0.004 0.0426 0.0798
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2458 0.5476
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0426 0.0424
Onchocerca volvulus 0.0043 0.0465 0.0886
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0153 0.0151
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.3523 0.3522
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.013 0.0051
Loa Loa (eye worm) hypothetical protein 0.004 0.0426 0.0424
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.012 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0426 0.0424
Trypanosoma cruzi cysteine peptidase, putative 0.01 0.1383 0.1381
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0112 0.011
Echinococcus granulosus cathepsin L 0.0022 0.013 0.0086
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0082 0.0079
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0413 0.0397
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.029 0.0287
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.012 0.0092
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0112 0.001
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.012 0.0092
Brugia malayi Inositol-1 0.004 0.0413 0.0411
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0079
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0426 0.0384
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0056 0.0423
Loa Loa (eye worm) hypothetical protein 0.0038 0.0382 0.038
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0082 0.0079
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0022 0.013 0.0127
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0119 0.0116
Schistosoma mansoni pyruvate kinase 0.004 0.0426 0.0423
Loa Loa (eye worm) hypothetical protein 0.0021 0.0119 0.0116
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0911 0.187
Brugia malayi ecdysone receptor 0.0019 0.0082 0.0079
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0911 0.0909
Toxoplasma gondii exonuclease III APE 0.0021 0.0108 0.0108
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0632 1 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.2467 0.2465
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0946 0.0906
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1332 0.133
Loa Loa (eye worm) cysteine protease 0.0043 0.0465 0.0462
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0071 0.0128
Trypanosoma cruzi cysteine proteinase, putative 0.0022 0.013 0.0127
Brugia malayi nuclear hormone receptor 0.0019 0.0082 0.0079
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.072 0.0679
Schistosoma mansoni lipoxygenase 0.01 0.1384 0.1382
Trypanosoma cruzi major cysteine proteinase, putative 0.0065 0.082 0.0818
Brugia malayi Cytochrome P450 family protein 0.0021 0.012 0.0117
Brugia malayi beta-lactamase family protein 0.007 0.0911 0.0909
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2458 0.5476
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.029 0.0287
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0426 0.0384
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.012 0.0092
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.013 0.0259
Onchocerca volvulus 0.0043 0.0465 0.0886
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0108 0.0064
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0911 0.1225
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.029 0.5951
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0082 0.0038
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0357 0.0357
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.029 0.0247
Loa Loa (eye worm) thioredoxin reductase 0.0092 0.1262 0.126
Loa Loa (eye worm) hypothetical protein 0.0056 0.068 0.0678
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0056 0.0039
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0413 0.3583
Echinococcus granulosus cathepsin l1 0.0043 0.0465 0.0422
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0426 0.0798
Loa Loa (eye worm) hypothetical protein 0.007 0.0911 0.0909
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0346 0.0661
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0426 0.0423
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0426 0.0384
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.029 0.0287
Entamoeba histolytica cysteine protease, putative 0.0043 0.0465 0.4253
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0453 0.041
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0082 0.0079
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0426 0.0893
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0426 0.0424
Toxoplasma gondii cathepsin CPL 0.0043 0.0465 0.0465
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0632 1 1
Mycobacterium tuberculosis Conserved protein 0.007 0.0911 0.1225
Brugia malayi Cathepsin L-like precursor 0.0043 0.0465 0.0462
Echinococcus multilocularis 0.0021 0.012 0.0076
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0426 0.0424
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0022 0.013 0.0127
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2458 0.5476
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0911 0.1225
Echinococcus multilocularis pyruvate kinase 0.0021 0.0109 0.0065
Plasmodium vivax hypothetical protein, conserved 0.007 0.0911 0.7211
Onchocerca volvulus 0.0286 0.44 1
Entamoeba histolytica cysteine protease, putative 0.0022 0.013 0.0259
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.012 0.0137
Entamoeba histolytica cysteine proteinase, putative 0.0043 0.0465 0.4253
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0346 0.0416
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.012 0.0137
Treponema pallidum NADH oxidase 0.0032 0.029 1
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0911 0.187
Schistosoma mansoni pyruvate kinase 0.004 0.0426 0.0423
Schistosoma mansoni hypothetical protein 0.0352 0.5467 0.5466
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0159 0.0115
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0946 0.0906
Loa Loa (eye worm) hypothetical protein 0.007 0.0911 0.0909
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0426 0.074
Trypanosoma cruzi cysteine peptidase, putative 0.01 0.1383 0.1381
Plasmodium falciparum cysteine proteinase falcipain 1 0.0022 0.013 0.0614
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0082 0.0038
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0426 0.0384
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0056 0.0011
Onchocerca volvulus 0.0029 0.0236 0.0358
Onchocerca volvulus 0.007 0.0911 0.1919
Loa Loa (eye worm) pyruvate kinase 0.004 0.0426 0.0423
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0022 0.013 0.0127
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0357 0.0314
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0426 0.053
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0343 0.03
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1383 0.1369
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0465 0.083
Trichomonas vaginalis set domain proteins, putative 0.0286 0.44 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0119 0.0116
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.068 0.0678
Loa Loa (eye worm) hypothetical protein 0.004 0.0426 0.0424
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0056 0.0053
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0413 0.0371
Plasmodium falciparum cysteine proteinase falcipain 3 0.0043 0.0465 0.3389
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0911 0.1225
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.096 0.092
Brugia malayi nuclear receptor RXR 0.0019 0.0082 0.0079
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0911 0.0909
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0085 0.1155 0.1153
Loa Loa (eye worm) hypothetical protein 0.004 0.0426 0.0424
Loa Loa (eye worm) hypothetical protein 0.0028 0.0229 0.0226
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0082 0.0079
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.012 0.0092
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0632 1 1
Leishmania major pyruvate kinase 0.004 0.0426 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.013 0.0051
Schistosoma mansoni nuclear hormone receptor 0.004 0.0426 0.0424
Schistosoma mansoni ap endonuclease 0.0021 0.0108 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.3865 0.8753
Brugia malayi PHD-finger family protein 0.0024 0.0169 0.0166
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0911 0.9421
Loa Loa (eye worm) ctsf protein 0.0043 0.0465 0.0462
Echinococcus granulosus cathepsin L cysteine protease 0.0022 0.013 0.0086
Schistosoma mansoni bromodomain containing protein 0.0062 0.0777 0.0774
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0911 0.1225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0465 0.083
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0082 0.0038
Onchocerca volvulus 0.0043 0.0465 0.0886
Entamoeba histolytica cysteine protease, putative 0.0022 0.013 0.0259
Echinococcus multilocularis lamin dm0 0.0056 0.068 0.0639
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0101 0.0099
Trypanosoma cruzi cysteine peptidase, putative 0.01 0.1383 0.1381
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1383 0.1369
Echinococcus multilocularis pyruvate kinase 0.0021 0.0109 0.0065
Echinococcus multilocularis muscleblind protein 1 0.018 0.2692 0.2659
Onchocerca volvulus 0.0024 0.0159 0.0179
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0911 0.187
Echinococcus granulosus muscleblind protein 0.018 0.2692 0.2659
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.096 0.1296
Loa Loa (eye worm) DR-78 0.0019 0.0082 0.0079
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.2458 0.5503
Echinococcus granulosus cathepsin l1 0.0029 0.0236 0.0193
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0022 0.013 0.0127
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0229 0.1437
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0108 0.0839
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.3865 0.8753
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0131 0.0129
Brugia malayi Bromodomain containing protein 0.0073 0.0962 0.096
Echinococcus granulosus pyruvate kinase 0.0021 0.0109 0.0065
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0426 0.0384
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.012 0.0092
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.029 0.0274
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.096 0.0945
Loa Loa (eye worm) hypothetical protein 0.0055 0.0664 0.0661
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0159 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2603 0.5812
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0119 0.0116
Loa Loa (eye worm) hypothetical protein 0.004 0.0426 0.0424
Echinococcus multilocularis cysteine protease 0.0043 0.0465 0.0422
Brugia malayi Bromodomain containing protein 0.0038 0.0381 0.0379
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0082 0.0038
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0082 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0426 0.0424
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0426 0.0424
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0632 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0426 0.0424
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0082 0.0079
Brugia malayi isocitrate dehydrogenase 0.0017 0.0056 0.0053
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.012 0.0137
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0043 0.0465 0.0422
Brugia malayi hypothetical protein 0.0021 0.0119 0.0116
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0056 0.0056
Loa Loa (eye worm) RecQ helicase 0.0021 0.0112 0.011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.029 0.0287
Brugia malayi hypothetical protein 0.0167 0.2467 0.2465
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0465 0.083
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2458 0.5476
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0192
Echinococcus multilocularis cysteine protease 0.0043 0.0465 0.0422
Brugia malayi beta-lactamase family protein 0.007 0.0911 0.0909
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0233 0.3547 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0159 0.0115
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0056 0.0039
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.029 0.5951
Mycobacterium tuberculosis Putative ferredoxin reductase 0.021 0.3168 0.4459
Trypanosoma cruzi cysteine peptidase, putative 0.0043 0.0465 0.0462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1383 0.1369
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0056 0.0039
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.072 0.0679
Loa Loa (eye worm) inositol-1 0.004 0.0413 0.0411
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0946 0.0944
Loa Loa (eye worm) beta-lactamase 0.007 0.0911 0.0909
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.096 0.092
Trypanosoma cruzi ISWI complex protein 0.0015 0.0016 0.0014
Brugia malayi beta-lactamase 0.007 0.0911 0.0909
Entamoeba histolytica cysteine protease, putative 0.0022 0.013 0.0259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1383 0.1369
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.012 0.0137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0465 0.083
Brugia malayi Muscleblind-like protein 0.018 0.2692 0.269
Echinococcus multilocularis cathepsin L cysteine protease 0.0043 0.0465 0.0422
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.029 0.029
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.012 0.0137
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.012 0.0092
Echinococcus granulosus pyruvate kinase 0.0021 0.0109 0.0065
Mycobacterium ulcerans lipase LipD 0.007 0.0911 0.9421
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.3865 0.3864
Brugia malayi nuclear receptor NHR-88 0.0019 0.0082 0.0079
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.029 0.0423
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0911 0.187
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0426 0.0424
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0259 0.0257
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0426 0.0384
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0108 0.0106
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0426 0.0384
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0426 0.0796
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0946 1
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0082 0.0079
Leishmania major cathepsin L-like protease 0.01 0.1383 0.1369
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.096 0.0958
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0465 0.083
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.096 0.0958
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0465 0.083
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0108 0.0092
Leishmania major cathepsin L-like protease 0.01 0.1383 0.1369
Entamoeba histolytica cysteine protease, putative 0.0022 0.013 0.0259
Entamoeba histolytica cysteine protease, putative 0.0022 0.013 0.0259
Brugia malayi Cytochrome P450 family protein 0.0032 0.0291 0.0289
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.029 0.2132
Schistosoma mansoni ap endonuclease 0.0021 0.0108 0.0106
Mycobacterium leprae Probable lipase LipE 0.007 0.0911 0.2308
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0079
Entamoeba histolytica cysteine protease, putative 0.0022 0.013 0.0259
Brugia malayi tailless protein 0.0019 0.0082 0.0079
Echinococcus multilocularis cathepsin L cysteine protease 0.0043 0.0465 0.0422
Leishmania major cytochrome p450-like protein 0.0021 0.012 0.0103
Plasmodium vivax unspecified product 0.0022 0.013 0.1011
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.012 0.0117
Echinococcus granulosus FTZ F1 alpha 0.004 0.0426 0.0384
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0131 0.0087
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0426 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1383 0.1369
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0426 0.0424
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.012 0.0092
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0426 0.0384
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.012 0.0092
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0426 0.0424
Loa Loa (eye worm) glutathione reductase 0.0092 0.1262 0.126
Echinococcus multilocularis pyruvate kinase 0.0032 0.0288 0.0245
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0082 0.0038
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.012 0.0092
Loa Loa (eye worm) hypothetical protein 0.0024 0.0159 0.0157
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.2421 0.2387
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0056 0.0056
Schistosoma mansoni nuclear receptor 0.0019 0.0082 0.0079
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.012 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0426 0.0424
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0413 0.0711
Plasmodium vivax vivapain-2 0.0043 0.0465 0.3669
Schistosoma mansoni zinc finger protein 0.0019 0.0082 0.0079
Loa Loa (eye worm) intermediate filament protein 0.0056 0.068 0.0678
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0426 0.0384
Echinococcus granulosus lamin 0.0056 0.068 0.0639
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.029 0.0287
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0043 0.0465 0.0422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0465 0.083
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.012 0.0092
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.029 0.0247
Loa Loa (eye worm) hypothetical protein 0.007 0.0911 0.0909
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.3865 0.3864
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0911 0.0896
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0236 0.0299
Leishmania major hypothetical protein, conserved 0.007 0.0911 0.0896
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.029 0.194
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0426 0.0424
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0911 0.0909
Entamoeba histolytica cysteine protease, putative 0.0022 0.013 0.0259
Brugia malayi nuclear receptor NHR-67 0.0019 0.0082 0.0079
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0235 0.3577 0.3575
Schistosoma mansoni intermediate filament proteins 0.0056 0.068 0.0678
Onchocerca volvulus 0.0043 0.0465 0.0886
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0082 0.0079
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0235 0.3577 0.3575
Toxoplasma gondii fructose-bisphospatase I 0.0235 0.3577 0.3577
Echinococcus granulosus intermediate filament protein 0.0056 0.068 0.0639
Loa Loa (eye worm) hypothetical protein 0.0053 0.0627 0.0625
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0291 0.0289
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0449 0.7035 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0079
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.029 0.0274
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0112 0.0068
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0119 0.0075
Brugia malayi glutathione reductase 0.0092 0.1262 0.126
Brugia malayi hypothetical protein 0.0024 0.0159 0.0157
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0082 0.0038
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0911 0.087
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.2078 0.2042
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0043 0.0465 0.3389
Schistosoma mansoni thyroid hormone receptor 0.0164 0.2421 0.2419
Schistosoma mansoni coup transcription factor 0.004 0.0426 0.0424
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.013 0.0259
Schistosoma mansoni polycystin 1-related 0.0024 0.0159 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.1383 0.1369

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 5.623413252 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 6.309573445 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 7.943282347 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 12.58925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
IC50 (functional) > 9.93 uM PUBCHEM_BIOASSAY: XBP1 DR counterscreen for CHOP. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
IC50 (functional) > 10 uM PUBCHEM_BIOASSAY: CHOP dose-response primary assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (binding) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 42.5615 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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