Detailed information for compound 1463733

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 407.341 | Formula: C21H27BrO3
  • H donors: 2 H acceptors: 2 LogP: 7.05 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H]1CCCC(C21CC[C@@H](c1c2c2cc(O)c(c(c2o1)Br)O)C)(C)C
  • InChi: 1S/C21H27BrO3/c1-11-7-9-21(12(2)6-5-8-20(21,3)4)15-13-10-14(23)17(24)16(22)19(13)25-18(11)15/h10-12,23-24H,5-9H2,1-4H3/t11-,12+,21?/m0/s1
  • InChiKey: PUQKUJIJCMJUNB-DORUZBFSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica phosphatidylinositol 3-kinase, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1068 aa 927 aa 29.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sugar transporter 0.001 0.0017 0.0017
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0164 0.2704
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0087 0.0551 0.0881
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0003 0.0003
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0008 0.0003 0.0006
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0003 0.0013
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0038 0.0118
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0003 0.0003
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0008 0.0003 0.0009
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Mycobacterium leprae Probable oxidoreductase 0.0008 0.0003 0.0009
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.008
Leishmania major 3-keto-dihydrosphingosine reductase 0.0008 0.0003 0.0013
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0085 0.1875
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0003 0.0013
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0181 0.2974
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0139 0.0308
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0008 0.0003 0.0006
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0038 0.0182
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0008 0.0003 0.0004
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0014 0.0031
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0003 0.0013
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0908 0.6256 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0123 0.0397
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0105 0.0167
Echinococcus granulosus histone lysine methyltransferase setb 0.0095 0.0607 0.0607
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0008 0.0003 0.0004
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Echinococcus multilocularis pyruvate kinase 0.0017 0.0067 0.0067
Echinococcus multilocularis retinol dehydrogenase 13 0.0008 0.0003 0.0003
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0014 0.0031
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0139 0.0308
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.026 0.1755 0.8493
Echinococcus granulosus bloom syndrome protein 0.0023 0.0105 0.0105
Mycobacterium tuberculosis Possible oxidoreductase 0.0008 0.0003 0.0009
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0008 0.0003 0.0009
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0017 0.008
Echinococcus granulosus lamin dm0 0.0028 0.0139 0.0139
Trypanosoma brucei unspecified product 0.0019 0.0082 0.0396
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0552 0.1823
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0003 0.0009
Plasmodium vivax basic transcription factor 3b, putative 0.0073 0.0456 0.7505
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0181 0.0874
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0105 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0186
Loa Loa (eye worm) glutathione reductase 0.0038 0.0212 0.0468
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0574 0.1268
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.001 0.0017 0.0017
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.011 0.0709 0.3431
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.008
Plasmodium falciparum thioredoxin reductase 0.0038 0.0212 0.4651
Brugia malayi Pre-SET motif family protein 0.0659 0.4527 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Chlamydia trachomatis pyruvate kinase 0.0034 0.0181 1
Brugia malayi Sugar transporter family protein 0.001 0.0017 0.0037
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0579 0.0579
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0186
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0038 0.0116
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.012 0.0782 0.1728
Brugia malayi Retinol dehydrogenase 12 0.0008 0.0003 0.0006
Entamoeba histolytica hypothetical protein 0.0008 0.0003 0.0004
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0364 0.2479 0.2479
Onchocerca volvulus Sepiapterin reductase homolog 0.0008 0.0003 0.0005
Onchocerca volvulus 0.0008 0.0003 0.0005
Leishmania major hypothetical protein, conserved 0.0008 0.0003 0.0013
Echinococcus multilocularis cpg binding protein 0.0032 0.0172 0.0172
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0181 0.0399
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0003 0.0003
Onchocerca volvulus 0.001 0.0017 0.0032
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0087 0.0551 0.0881
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0008 0.0003 0.0009
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0034 0.0182 0.2568
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.0753 0.3642
Entamoeba histolytica hypothetical protein, conserved 0.0008 0.0003 0.0004
Brugia malayi hypothetical protein 0.001 0.0017 0.0037
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.004 0.0087
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0552 0.1823
Mycobacterium ulcerans sugar transporter 0.001 0.0017 0.0046
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0181 0.035
Echinococcus multilocularis oxidoreductase 0.0008 0.0003 0.0003
Plasmodium vivax glutathione reductase, putative 0.0038 0.0212 0.349
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0013 0.0065
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0119 0.0776 0.0776
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0082 0.0082
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0017 0.0037
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0181 0.0874
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0003 0.0013
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.001 0.0017 0.0055
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0186
Giardia lamblia Reductase, putative 0.0008 0.0003 0.0004
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0071 0.0071
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0008 0.0003 0.0009
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0003 0.0003
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0087 0.0551 0.0551
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0034 0.0182 0.0182
Brugia malayi hypothetical protein 0.0008 0.0003 0.0006
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.095 0.4596
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0008 0.0003 0.0009
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0038 0.0118
Onchocerca volvulus 0.0028 0.0139 0.027
Schistosoma mansoni hypothetical protein 0.0174 0.1158 0.1158
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0574 0.0574
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0038 0.0186
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0137 0.1929
Loa Loa (eye worm) hypothetical protein 0.0169 0.1118 0.2469
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0181 0.0289
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Schistosoma mansoni lamin 0.0028 0.0139 0.0139
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.0753 0.2485
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0031 0.005
Leishmania major pyruvate kinase 0.0034 0.0181 0.0874
Schistosoma mansoni carbonyl reductase 0.0008 0.0003 0.0003
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0164 0.0263
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0164 0.2316
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0003 0.0013
Echinococcus granulosus pyruvate kinase 0.0017 0.0067 0.0067
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.026 0.1755 0.2805
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.001 0.0017 0.0046
Giardia lamblia Kinase, CMGC MAPK 0.011 0.0709 0.1133
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0181 0.035
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0709 0.0709
Leishmania major short chain dehydrogenase-like protein 0.0008 0.0003 0.0013
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0095 0.0607 0.0607
Schistosoma mansoni sugar transporter 0.001 0.0017 0.0017
Onchocerca volvulus 0.0008 0.0003 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.004 0.0193
Schistosoma mansoni cpg binding protein 0.0032 0.0172 0.0172
Mycobacterium ulcerans hypothetical protein 0.0161 0.1063 0.3504
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.026 0.1755 0.2805
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.062 0.2046
Brugia malayi hypothetical protein 0.0018 0.0069 0.0153
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0753 0.0753
Giardia lamblia Sugar-proton symporter 0.001 0.0017 0.0026
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0012 0.0012
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.011 0.0242
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0181 0.0874
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0038 0.0083
Trichomonas vaginalis glucose transporter, putative 0.001 0.0017 0.0026
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0038 0.0083
Giardia lamblia Pyruvate kinase 0.0017 0.0067 0.0107
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0038 0.0844
Plasmodium falciparum steroid dehydrogenase, putative 0.0008 0.0003 0.006
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0245 0.1183
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0038 0.0186
Schistosoma mansoni pyruvate kinase 0.0034 0.0181 0.0181
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0137 0.0662
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0552 0.1823
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0008 0.0003 0.0009
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0397 0.0397
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0186
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0034 0.0182 0.0402
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Plasmodium falciparum thioredoxin reductase 0.0013 0.0038 0.0844
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0164 0.3603
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0008 0.0003 0.0038
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0038
Trichomonas vaginalis glucose transporter, putative 0.001 0.0017 0.0026
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0008 0.0003 0.0004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0012 0.0166
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0003 0.0009
Onchocerca volvulus 0.001 0.0017 0.0032
Entamoeba histolytica short chain dehydrogenase family protein 0.0008 0.0003 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Schistosoma mansoni glucose transport protein 0.001 0.0017 0.0017
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Echinococcus multilocularis musashi 0.0028 0.0139 0.0139
Echinococcus granulosus pyruvate kinase 0.0034 0.0181 0.0181
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0123 0.1735
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0038
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0038 0.0038
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0212 0.07
Plasmodium vivax steroid dehydrogenase, putative 0.0008 0.0003 0.0045
Loa Loa (eye worm) sugar transporter 0.001 0.0017 0.0037
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0123 0.0406
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0182 0.0881
Echinococcus multilocularis pyruvate kinase 0.0017 0.0067 0.0067
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0709 0.1133
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0123 0.0595
Trypanosoma brucei transcription factor BTF3, putative 0.0073 0.0456 0.2206
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0397 0.0397
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0003 0.0013
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0038 0.0543
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0.0003 0.0013
Brugia malayi POT family protein 0.0084 0.053 0.1171
Loa Loa (eye worm) POT family protein 0.0084 0.053 0.1171
Onchocerca volvulus 0.0008 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.2067 1
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0038 0.0061
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0003 0.0009
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.2067 1
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0003 0.0013
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0038
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0017 0.008
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0164 0.0202
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0087 0.0551 0.0881
Brugia malayi Cytochrome P450 family protein 0.0013 0.0038 0.0083
Entamoeba histolytica transcription factor BTF3, putative 0.0073 0.0456 0.0729
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Echinococcus granulosus Sugar transporter ERD6 protein 0.001 0.0017 0.0017
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0008 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0607 0.0607
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0012 0.0026
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.005 0.011
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0123 0.0397
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0008 0.0003 0.0005
Brugia malayi Cytochrome P450 family protein 0.0013 0.0038 0.0083
Loa Loa (eye worm) oxidoreductase 0.0008 0.0003 0.0006
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.031 0.1499
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.0753 0.0753
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0003 0.0004
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0112 0.0726 0.1604
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0003 0.0013
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0008 0.0003 0.0003
Loa Loa (eye worm) oxidoreductase 0.0008 0.0003 0.0006
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0038 0.0118
Leishmania major glucose transporter/membrane transporter D2, putative 0.001 0.0017 0.008
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0003 0.0003
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0137 0.2251
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0082 0.0082
Echinococcus multilocularis dna polymerase eta 0.0019 0.0082 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Plasmodium falciparum hexose transporter 0.001 0.0017 0.0362
Schistosoma mansoni glucose transport protein 0.001 0.0017 0.0017
Leishmania major pteridine reductase 1 0.0008 0.0003 0.0013
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0082 0.0082
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0003 0.0003
Toxoplasma gondii facilitative glucose transporter GT1 0.001 0.0017 0.0233
Schistosoma mansoni sugar transporter 0.001 0.0017 0.0017
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0245 0.1183
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0034 0.0182 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0607 0.0607
Trypanosoma cruzi glucose transporter, putative 0.001 0.0017 0.008
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.0024 0.0024
Echinococcus multilocularis conserved hypothetical protein 0.0008 0.0003 0.0003
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0182 0.0881
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.011 0.0709 0.3431
Onchocerca volvulus Putative transporter 0.001 0.0017 0.0032
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0182 0.0881
Plasmodium vivax SET domain protein, putative 0.0095 0.0607 1
Onchocerca volvulus 0.0008 0.0003 0.0005
Plasmodium falciparum glutathione reductase 0.0038 0.0212 0.4651
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Onchocerca volvulus 0.0008 0.0003 0.0005
Leishmania major hypothetical protein, conserved 0.001 0.0013 0.0065
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0067 0.1462
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0003 0.0003
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0003 0.0038
Trichomonas vaginalis steroid dehydrogenase, putative 0.0008 0.0003 0.0004
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.062 0.2046
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0397 0.1302
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Loa Loa (eye worm) hypothetical protein 0.0095 0.0607 0.1342
Trichomonas vaginalis myo-inositol transporter, putative 0.001 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.0174 0.1158 0.1158
Schistosoma mansoni pyruvate kinase 0.0034 0.0181 0.0181
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0087 0.0551 0.1218
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Onchocerca volvulus 0.001 0.0017 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0607 0.0607
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0164 0.0263
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0038 0.0186
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0017 0.0017
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0181 0.035
Schistosoma mansoni carbonyl reductase 0.0008 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0207 0.1386 0.2215
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0003 0.0013
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0123 0.1735
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0017 0.0037
Brugia malayi phosphofructokinase 0.0116 0.0753 0.1662
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.001 0.0017 0.0362
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0003 0.0003
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Echinococcus granulosus oxidoreductase 0.0008 0.0003 0.0003
Brugia malayi MAP kinase sur-1 0.011 0.0709 0.1566
Echinococcus granulosus steroid dehydrogenase 0.0008 0.0003 0.0003
Schistosoma mansoni cpg binding protein 0.0031 0.0159 0.0159
Schistosoma mansoni glucose transport protein 0.001 0.0017 0.0017
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0374 0.5276
Loa Loa (eye worm) hypothetical protein 0.0027 0.0136 0.03
Plasmodium vivax hexose transporter 0.001 0.0017 0.0272
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0105 0.0231
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0031 0.015
Schistosoma mansoni hypothetical protein 0.001 0.0017 0.0017
Onchocerca volvulus 0.001 0.0017 0.0032
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0585 0.4016 0.6419
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0082 0.027
Entamoeba histolytica hypothetical protein 0.0073 0.0456 0.0729
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0003 0.0004
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0038 0.0633
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0038 0.0186
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0397 0.0397
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0212 0.1026
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0034 0.0182 0.0182
Giardia lamblia Pyruvate kinase 0.0034 0.0181 0.0289
Trypanosoma cruzi hexose transporter, putative 0.001 0.0017 0.008
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0123 0.5946
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0012 0.0019
Loa Loa (eye worm) phosphofructokinase 0.0116 0.0753 0.1662
Onchocerca volvulus 0.0008 0.0003 0.0005
Leishmania major phosphatidylinositol 3-kinase, putative 0.0034 0.0182 0.0881
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0119 0.0776 0.0776
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0574 0.0574
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0186
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0008 0.0003 0.0009
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0008 0.0003 0.0009
Echinococcus granulosus pyruvate kinase 0.0017 0.0067 0.0067
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.008
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0031 0.015
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0034 0.0182 0.0291
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0038 0.0186
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0038 0.0633
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0003 0.0004
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0003 0.0013
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0003 0.0038
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Echinococcus granulosus hypothetical protein 0.0008 0.0003 0.0003
Echinococcus multilocularis transcription factor btf3 0.0073 0.0456 0.0456
Onchocerca volvulus 0.001 0.0017 0.0032
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0052 0.0736
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0585 0.4016 0.6419
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Echinococcus multilocularis pyruvate kinase 0.0027 0.0131 0.0131
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.008
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0456 0.0729
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0397 0.0397
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.001 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0025
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0082 0.0082
Mycobacterium tuberculosis Probable dehydrogenase 0.0008 0.0003 0.0009
Leishmania major short chain dehydrogenase, putative 0.0008 0.0003 0.0013
Echinococcus granulosus solute carrier family 22 0.001 0.0017 0.0017
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0017 0.0017
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0038 0.0186
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0245 0.1183
Loa Loa (eye worm) ICD-1 protein 0.0073 0.0456 0.1007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0115 0.0748 0.1196
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0026
Echinococcus granulosus transcription factor btf3 0.0073 0.0456 0.0456
Brugia malayi CXXC zinc finger family protein 0.0031 0.0159 0.0352
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0003 0.0013
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.008
Trypanosoma brucei glucose transporter 1E 0.001 0.0017 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.6256 1
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0013 0.0065
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0105 0.0167
Leishmania major hypothetical protein, conserved 0.0027 0.0137 0.0662
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0008 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0026
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.0753 0.2478
Loa Loa (eye worm) hypothetical protein 0.0034 0.0181 0.0399
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0008 0.0003 0.0009
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0053 0.088
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0245 0.1183
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0397 0.1302
Trypanosoma cruzi sugar transporter, putative 0.001 0.0017 0.008
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Giardia lamblia Short-chain dehydrogenase, putative 0.0008 0.0003 0.0004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0012 0.0166
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0012 0.0258
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0003 0.0003
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0164 0.0263
Echinococcus multilocularis Sugar transporter ERD6 protein 0.001 0.0017 0.0017
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0119 0.0776 0.1715
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0079 0.0498 0.2409
Leishmania major hypothetical protein, conserved 0.0008 0.0003 0.0013
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.012 0.0782 0.0782
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0012 0.0026
Onchocerca volvulus 0.001 0.0017 0.0032
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.001 0.0017 0.0046
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0012 0.0026
Brugia malayi Pre-SET motif family protein 0.0095 0.0607 0.1342
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0003 0.0013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0036 0.0036
Onchocerca volvulus 0.001 0.0017 0.0032
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0003 0.0003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0024 0.0024
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0028 0.0139 0.0308
Loa Loa (eye worm) hypothetical protein 0.0092 0.0584 0.1289
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.008
Echinococcus multilocularis mitogen activated protein kinase 3 0.011 0.0709 0.0709
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0003 0.0013
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.011 0.0709 0.3431
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Leishmania major hypothetical protein, conserved 0.0008 0.0003 0.0013
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.008
Onchocerca volvulus 0.0008 0.0003 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0082 0.0396
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0397 0.192
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1063 0.351
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.095 0.4596
Schistosoma mansoni DNA helicase recq1 0.0009 0.0012 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0164 0.0263
Mycobacterium tuberculosis Possible oxidoreductase 0.0008 0.0003 0.0009
Trypanosoma cruzi hexose transporter, putative 0.001 0.0017 0.008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.026 0.1755 0.3877
Trypanosoma brucei trypanothione reductase 0.0038 0.0212 0.1026
Echinococcus granulosus Solute carrier family 22 5 0.1065 0.735 0.735
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.012 0.0782 0.2576
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0034 0.0182 0.2997
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0169 0.1118 0.1118
Brugia malayi Dehydrogenases, short chain protein 30 0.0008 0.0003 0.0006
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.026 0.1755 0.2805
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0164 0.2316
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0181 0.0399
Brugia malayi intermediate filament protein 0.0028 0.0139 0.0308
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0082 0.0396
Echinococcus multilocularis pyruvate kinase 0.0034 0.0181 0.0181
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0137 0.0662
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0008 0.0003 0.0003
Echinococcus multilocularis pyruvate kinase 0.0017 0.0067 0.0067
Schistosoma mansoni glucose transporter 0.001 0.0017 0.0017
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0008 0.0003 0.0004
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.0753 0.2485
Brugia malayi 6-phosphofructokinase 0.0116 0.0753 0.1662
Loa Loa (eye worm) oxidoreductase 0.0008 0.0003 0.0006
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0036 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.004 0.0193
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0003 0.0013
Onchocerca volvulus 0.001 0.0017 0.0032
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0038 0.0127
Trichomonas vaginalis sugar transport protein, putative 0.001 0.0017 0.0026
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0038 0.0186
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0.0003 0.0013
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0123 0.2698
Schistosoma mansoni pyruvate kinase 0.0017 0.0067 0.0067
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0038 0.0085
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0038 0.2973
Trypanosoma brucei unspecified product 0.0013 0.004 0.0193
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0082 0.0396
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0216 0.0216
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0753 0.1662
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0003 0.0013
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.012 0.0782 0.2583
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0008 0.0003 0.0013
Giardia lamblia Fructose-bisphosphate aldolase 0.0908 0.6256 1
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0036 0.0081
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0123 0.0595
Mycobacterium tuberculosis Probable reductase 0.0087 0.0552 0.1823
Onchocerca volvulus 0.001 0.0017 0.0032
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0008 0.0003 0.0009
Onchocerca volvulus 0.001 0.0017 0.0032
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0017 0.008
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0003 0.0009
Leishmania major hypothetical protein, conserved 0.001 0.0017 0.008
Onchocerca volvulus 0.0008 0.0003 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0038 0.0186
Toxoplasma gondii sugar transporter ST2 0.001 0.0017 0.0233
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0126 0.0819 0.131
Echinococcus granulosus mitogen activated protein kinase 3 0.011 0.0709 0.0709
Entamoeba histolytica hypothetical protein 0.0025 0.0123 0.0197
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0082 0.027
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0017 0.0017
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0038 0.0038
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0017 0.0017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0036 0.0036
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.026 0.1755 0.2805
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0003 0.0003
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0003 0.0004
Treponema pallidum fructose-bisphosphate aldolase 0.0908 0.6256 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0034 0.0182 0.0182
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0038 0.0182
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0031 0.015
Mycobacterium ulcerans integral membrane transport protein 0.001 0.0017 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.6256 1
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0095 0.0607 0.0607
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0003 0.0013
Entamoeba histolytica short chain dehydrogenase family protein 0.0008 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0008 0.0003 0.0005
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0008 0.0003 0.0038
Onchocerca volvulus 0.001 0.0017 0.0032
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.004 0.004
Echinococcus granulosus intermediate filament protein 0.0028 0.0139 0.0139
Loa Loa (eye worm) RecQ helicase 0.0023 0.0105 0.0231
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Trypanosoma cruzi hexose transporter, putative 0.001 0.0017 0.008
Echinococcus granulosus synaptic vesicle 2 protein 0.001 0.0017 0.0017
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Toxoplasma gondii NAC domain-containing protein 0.0073 0.0456 0.6429
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0364 0.2479 0.2479
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0038 0.0038
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0119 0.0776 0.0776
Loa Loa (eye worm) oxidoreductase 0.0008 0.0003 0.0006
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0164 0.3603
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.011 0.0709 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0443 0.3029 1
Echinococcus granulosus mitogen activated protein kinase 0.011 0.0709 0.0709
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0164 0.0263
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0082 0.0131
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.012 0.0782 0.3785
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0026
Echinococcus granulosus dna polymerase kappa 0.0019 0.0082 0.0082
Brugia malayi major facilitator superfamily protein 0.001 0.0017 0.0037
Brugia malayi hypothetical protein 0.001 0.0017 0.0037
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0087 0.0551 0.2668
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0026
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Echinococcus granulosus pyruvate kinase 0.0017 0.0067 0.0067
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0008 0.0003 0.0004
Leishmania major myo-inositol/proton symporter (MIT) 0.001 0.0017 0.008
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0164 0.0263
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0164 0.8846
Schistosoma mansoni carbonyl reductase 0.0008 0.0003 0.0003
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0119 0.0776 0.0776
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0364 0.2479 0.2479
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0012 0.0012
Onchocerca volvulus 0.075 0.5159 1
Onchocerca volvulus 0.001 0.0017 0.0032
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0003 0.0009
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.001 0.0017 0.0017
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0212 0.349
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0008 0.0003 0.0003
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0003 0.0003
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.008
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0212 0.0468
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0087 0.0551 0.0881
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0082 0.0396
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0186
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0038 0.0061
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0753 0.1203
Loa Loa (eye worm) hypothetical protein 0.009 0.0574 0.1268
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0003 0.0013
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0034 0.0182 0.0402
Leishmania major glucose transporter, lmgt1 0.001 0.0017 0.008
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0008 0.0003 0.0013
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.0024 0.0024
Toxoplasma gondii hypothetical protein 0.0049 0.0288 0.4068
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0123 0.2025
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0003 0.0013
Trypanosoma brucei unspecified product 0.0013 0.004 0.0193
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0038 0.0083
Leishmania major glucose transporter, lmgt2 0.001 0.0017 0.008
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0008 0.0003 0.006
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0003 0.0009
Onchocerca volvulus 0.0008 0.0003 0.0005
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0169 0.1118 0.1118
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0003 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0082 0.0396
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0181 0.0588
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0003 0.0045
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.2067 1
Loa Loa (eye worm) oxidoreductase 0.0008 0.0003 0.0006
Echinococcus multilocularis mitogen activated protein kinase 0.011 0.0709 0.0709
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0003 0.0003
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0181 0.0874
Schistosoma mansoni lamin 0.0028 0.0139 0.0139
Giardia lamblia Hexose transporter 0.001 0.0017 0.0026
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0087 0.0551 0.2668
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0753 0.1662
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0038 0.0186
Trypanosoma cruzi transcription factor btf3, putative 0.0073 0.0456 0.2206
Onchocerca volvulus 0.0008 0.0003 0.0005
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0179 0.1189 0.19
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0753 0.1203
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0003 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0709 0.1133
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0061 0.0369 0.059
Schistosoma mansoni DNA polymerase eta 0.0019 0.0082 0.0082
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0137 0.0662
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0003 0.0003
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.0753 0.1148
Echinococcus granulosus lamin 0.0028 0.0139 0.0139
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0753 0.3642
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0443 0.3029 1
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.011 0.0175
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.6256 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0034 0.0182 0.0291
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.0242
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0008 0.0003 0.0009
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.0753 0.0753
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0003 0.0009
Brugia malayi beta-NAC-like protein 0.0073 0.0456 0.1007
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0753 0.1203
Leishmania major oxidoreductase-like protein 0.0008 0.0003 0.0013
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.011 0.0709 0.1566
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Toxoplasma gondii sugar transporter ST1 0.001 0.0017 0.0233
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0181 0.0289
Trypanosoma brucei sugar transporter, putative 0.001 0.0017 0.008
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0137 0.3
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.011 0.0709 0.3431
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0008 0.0003 0.0013
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0008 0.0003 0.0013
Onchocerca volvulus 0.0095 0.0607 0.1177
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0003 0.0013
Onchocerca volvulus 0.0008 0.0003 0.0005
Echinococcus multilocularis lamin 0.0028 0.0139 0.0139
Toxoplasma gondii sugar transporter ST3 0.001 0.0017 0.0233
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0181 0.0399
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0034 0.0182 0.0291
Brugia malayi Sugar transporter family protein 0.001 0.0017 0.0037
Loa Loa (eye worm) dehydrogenase 0.0008 0.0003 0.0006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0397 0.131
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0008 0.0003 0.006
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0552 0.1823
Schistosoma mansoni intermediate filament proteins 0.0028 0.0139 0.0139
Schistosoma mansoni transcription factor btf3 0.0073 0.0456 0.0456
Loa Loa (eye worm) oxidoreductase 0.0008 0.0003 0.0006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0003 0.0009
Brugia malayi dehydrogenases, short chain protein 2 0.0008 0.0003 0.0006
Onchocerca volvulus 0.009 0.0574 0.1113
Trypanosoma cruzi hexose transporter 0.001 0.0017 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.6256 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0026
Onchocerca volvulus 0.0008 0.0003 0.0005
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0003 0.0004
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0003 0.0013
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Leishmania major hypothetical protein, conserved 0.0008 0.0003 0.0013
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0038 0.0844
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0753 0.0753
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.6256 1
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0181 0.2548
Echinococcus granulosus hypothetical protein 0.0008 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.004 0.0193
Echinococcus multilocularis synaptic vesicle 2 protein 0.001 0.0017 0.0017
Leishmania major short chain dehydrogenase, putative 0.0008 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.0161
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0182 0.0881
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0017 0.0017
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0008 0.0003 0.0009
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Giardia lamblia DINP protein human, muc B family 0.0019 0.0082 0.0131
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0017 0.0037
Leishmania major cytochrome p450-like protein 0.0013 0.0038 0.0182
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0082 0.0181
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0067 0.1097
Echinococcus granulosus solute carrier family 22 0.001 0.0017 0.0017
Brugia malayi Dehydrogenases, short chain protein 2 0.0008 0.0003 0.0006
Onchocerca volvulus 0.001 0.0017 0.0032
Echinococcus multilocularis solute carrier family 22 0.001 0.0017 0.0017
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0082 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0456 0.0729
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0552 0.1823
Brugia malayi hypothetical protein 0.0027 0.0137 0.0302
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0017 0.0017
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.012 0.0782 0.0782
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0574 0.0574
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.095 0.4596
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0186
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Plasmodium falciparum basic transcription factor 3b, putative 0.0073 0.0456 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Toxoplasma gondii carbonyl reductase 1, putative 0.0008 0.0003 0.0038
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0008 0.0003 0.0013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0139 0.0308
Leishmania major DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0552 0.1823
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Echinococcus multilocularis Zinc finger, PHD finger 0.0034 0.0182 0.0182
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0003 0.0013
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Schistosoma mansoni hypothetical protein 0.0012 0.0032 0.0032
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0443 0.3029 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0164 0.8846
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0709 0.1133
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0003 0.0009
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0038
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0181 0.0399
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0017 0.0037
Echinococcus granulosus geminin 0.0174 0.1158 0.1158
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0082 0.0181
Loa Loa (eye worm) dehydrogenase 0.0008 0.0003 0.0006
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0003 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0753 0.1203
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0032 0.0032
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0397 0.5596
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0067 0.094
Echinococcus granulosus solute carrier family 22 0.001 0.0017 0.0017
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0008 0.0003 0.0009
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0082 0.0131
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Echinococcus multilocularis microtubule associated protein 2 0.1446 1 1
Onchocerca volvulus 0.001 0.0017 0.0032
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0017 0.0038
Loa Loa (eye worm) phosphatidylinositol 3 0.0311 0.211 0.4661
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0017 0.0037
Onchocerca volvulus 0.0028 0.0139 0.027
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0003 0.0003
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0034 0.0182 0.2568
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0003 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.6256 1
Leishmania major pyruvate kinase 0.0034 0.0181 0.0874
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0008 0.0003 0.0013
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0008 0.0003 0.0009
Echinococcus multilocularis solute carrier family 22 0.001 0.0017 0.0017
Loa Loa (eye worm) oxidoreductase 0.0008 0.0003 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0397 0.1302
Echinococcus granulosus cpg binding protein 0.0032 0.0172 0.0172
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0003 0.0013
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0034 0.0182 0.3994
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0008 0.0003 0.0009
Loa Loa (eye worm) sugar transporter 0.001 0.0017 0.0037
Toxoplasma gondii thioredoxin reductase 0.0038 0.0212 0.299
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0038 0.2973
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Echinococcus granulosus WW domain containing oxidoreductase 0.0008 0.0003 0.0003
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0012 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0095 0.0607 0.0607
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.012 0.0782 0.0782
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0008 0.0003 0.0005
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0181 0.0596
Schistosoma mansoni DNA helicase recq5 0.0009 0.0012 0.0012
Leishmania major trypanothione reductase 0.0038 0.0212 0.1026
Echinococcus multilocularis lamin dm0 0.0028 0.0139 0.0139
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0087 0.0551 0.0881
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0008 0.0003 0.0009
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0119 0.0776 0.1715
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0207 0.1386 0.2215
Trypanosoma brucei protein kinase, putative 0.011 0.0709 0.3431
Echinococcus multilocularis solute carrier family 22 0.001 0.0017 0.0017
Leishmania major basic transcription factor 3a, putative 0.0073 0.0456 0.2206
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Brugia malayi hypothetical protein 0.0008 0.0003 0.0006
Leishmania major DNA polymerase eta, putative 0.0019 0.0082 0.0396
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0038 0.0543
Loa Loa (eye worm) phosphatidylinositol 3 0.0079 0.0498 0.11
Plasmodium falciparum pyruvate kinase 0.0034 0.0181 0.3962
Entamoeba histolytica hypothetical protein, conserved 0.0008 0.0003 0.0004
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0123 0.0136
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0709 0.1133
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.026 0.1755 0.8493
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0095 0.0607 0.8567
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0082 0.0262
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0252 0.1702 0.272
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0164 0.2704
Brugia malayi glutathione reductase 0.0038 0.0212 0.0468
Echinococcus granulosus pyruvate kinase 0.0034 0.0181 0.0181
Onchocerca volvulus 0.001 0.0017 0.0032
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0422 0.0422
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0159 0.0352
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.062 0.2046
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0456 0.0729
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0753 0.1203
Giardia lamblia Hypothetical protein 0.0008 0.0003 0.0004
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Trypanosoma brucei glucose transporter 2A 0.001 0.0017 0.008
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0753 0.3642
Trichomonas vaginalis set domain proteins, putative 0.075 0.5159 0.8246
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0003 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.6256 1
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0753 0.1203
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0038 0.0182
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0003 0.0003
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.004 0.004
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0164 0.0263
Trichomonas vaginalis glucose transporter, putative 0.001 0.0017 0.0026
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.001 0.0017 0.1148
Echinococcus multilocularis pyruvate kinase 0.0034 0.0181 0.0181
Trypanosoma cruzi transcription factor btf3, putative 0.0073 0.0456 0.2206
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0908 0.6256 1
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0181 0.0399
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0001 0.0001
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0003 0.0013
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.005 0.011
Brugia malayi major facilitator superfamily protein 0.001 0.0017 0.0037
Brugia malayi hypothetical protein 0.001 0.0017 0.0037
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0119 0.0776 0.0776
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.001 0.0017 0.008
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0038 0.0061
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0032 0.0032
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0082 0.0181
Plasmodium vivax sugar transporter, putative 0.001 0.0017 0.0272
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0169 0.1118 0.2469
Schistosoma mansoni microtubule-associated protein tau 0.1446 1 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0034 0.0182 0.0291
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0164 0.0263
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0137 0.3
Onchocerca volvulus 0.0031 0.0159 0.0309
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0003 0.0013
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0123 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0082 0.0131
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0104 0.0671 0.1481
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.011 0.0709 0.3431
Onchocerca volvulus 0.001 0.0017 0.0032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.6256 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0186
Onchocerca volvulus 0.0008 0.0003 0.0005
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0003 0.0013
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0181 0.0596
Echinococcus multilocularis geminin 0.0174 0.1158 0.1158
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0003 0.0013
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.011 0.0709 0.3431
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0008 0.0003 0.0038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0659 0.4527 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0034 0.0182 0.0182
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0031 0.005
Echinococcus granulosus dna polymerase eta 0.0019 0.0082 0.0082
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0008 0.0003 0.0009
Echinococcus granulosus solute carrier family 22 0.001 0.0017 0.0017
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0123 0.0406
Schistosoma mansoni cpg binding protein 0.0032 0.0172 0.0172
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0164 0.0263
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0181
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0003 0.0013
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0008 0.0003 0.0006
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0082 0.0082
Loa Loa (eye worm) oxidoreductase 0.0008 0.0003 0.0006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0003 0.0004
Brugia malayi dehydrogenases, short chain protein 9 0.0008 0.0003 0.0006
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0037
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0026
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0034 0.0182 0.0291
Schistosoma mansoni fkbp-rapamycin associated protein 0.0008 0.00000002749 0.00000002749
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0003 0.0004
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0164 0.2316
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0038
Leishmania major dehydrogenase-like protein 0.0008 0.0003 0.0013
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0017 0.0017
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Echinococcus multilocularis solute carrier family 22 0.001 0.0017 0.0017
Trypanosoma cruzi hexose transporter, putative 0.001 0.0017 0.008
Brugia malayi oxidoreductase 0.0008 0.0003 0.0006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0003 0.0009
Brugia malayi Sugar transporter family protein 0.001 0.0017 0.0037
Schistosoma mansoni sugar transporter 0.001 0.0017 0.0017
Loa Loa (eye worm) oxidoreductase 0.0008 0.0003 0.0006
Trypanosoma brucei oxidoreductase-like protein 0.0008 0.0003 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0026
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.012 0.0782 0.2576
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0082 0.0396
Toxoplasma gondii transporter, major facilitator family protein 0.001 0.0017 0.0233
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0003 0.0013
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0003 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0082 0.0396
Leishmania major glucose transporter, lmgt3 0.001 0.0017 0.008
Brugia malayi Thioredoxin reductase 0.0038 0.0212 0.0468
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0024 0.0024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0024 0.0024
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.2067 1
Plasmodium falciparum glutathione reductase 0.0013 0.0038 0.0844
Loa Loa (eye worm) hypothetical protein 0.0027 0.0137 0.0302
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0026
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0179 0.1189 0.19
Brugia malayi 6-phosphofructokinase 0.0116 0.0753 0.1662
Leishmania major hypothetical protein, conserved 0.0008 0.0003 0.0013
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.011 0.0709 0.3431
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0753 0.1203
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.062 0.2046
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0006

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.7 uM Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assay ChEMBL. 21121631
IC50 (binding) = 5.3 uM Inhibition of human PI3Kgamma expressed in Sf9 cells by fluorescent polarization assay ChEMBL. 21121631

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.