Detailed information for compound 1564712

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 497.375 | Formula: C21H16F5N5O4
  • H donors: 2 H acceptors: 4 LogP: 1.46 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCC1CN(C/C/1=N\OC(F)F)c1nc2c(cc1F)c(=O)c(cn2c1ccc(cc1F)F)C(=O)O
  • InChi: 1S/C21H16F5N5O4/c22-10-1-2-16(13(23)3-10)31-7-12(20(33)34)17(32)11-4-14(24)19(28-18(11)31)30-6-9(5-27)15(8-30)29-35-21(25)26/h1-4,7,9,21H,5-6,8,27H2,(H,33,34)/b29-15+
  • InChiKey: ZQKMASQSMWZNHC-WKULSOCRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Myosin head containing protein 0.0005 0.0001 0.0003
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0026 0.035 0.1291
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.023 0.0845
Loa Loa (eye worm) HMG box family protein 0.0057 0.0856 0.1977
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Onchocerca volvulus 0.0026 0.035 0.0735
Brugia malayi hypothetical protein 0.0268 0.4331 1
Brugia malayi Tubulin beta chain 0.0128 0.2022 0.4668
Trypanosoma brucei alpha tubulin 0.0226 0.3639 1
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.06 0.0585
Loa Loa (eye worm) hypothetical protein 0.0128 0.2022 0.4668
Plasmodium vivax delta tubulin, putative 0.0098 0.1531 0.4206
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0089 0.1375 0.1362
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0026 0.035 0.0809
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0019 0.023 0.141
Schistosoma mansoni tubulin subunit beta 0.0226 0.3639 0.3629
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0037
Schistosoma mansoni microtubule-associated protein tau 0.0613 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0532 0.0516
Echinococcus multilocularis tubulin alpha chain 0.0226 0.3639 0.3629
Loa Loa (eye worm) patched family protein 0.0005 0.0001 0.0003
Schistosoma mansoni tubulin subunit epsilon 0.0226 0.3639 0.3629
Entamoeba histolytica tubulin gamma chain 0.0226 0.3639 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0159 0.0583
Onchocerca volvulus 0.005 0.0739 0.1554
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0046 0.003
Schistosoma mansoni tyrosine kinase 0.0077 0.1184 0.117
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0038 0.0532 0.0516
Echinococcus multilocularis musashi 0.0048 0.0697 0.0682
Plasmodium vivax tubulin epsilon chain, putative 0.0226 0.3639 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0226 0.3639 0.766
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.023 0.059
Mycobacterium leprae cell division protein FtsZ 0.0098 0.1531 1
Echinococcus granulosus hypothetical protein 0.0265 0.4278 0.4269
Loa Loa (eye worm) hypothetical protein 0.0023 0.0292 0.0674
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0019 0.023 0.141
Loa Loa (eye worm) BEN-1 protein 0.0226 0.3639 0.8402
Brugia malayi Cell division protein ftsZ 0.0098 0.1531 0.3536
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0036 0.05 0.0484
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0358 0.0943
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0145 0.0357
Loa Loa (eye worm) intermediate filament protein 0.0048 0.0697 0.161
Entamoeba histolytica hypothetical protein 0.0042 0.06 0.1613
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Echinococcus multilocularis cpg binding protein 0.0028 0.0381 0.0366
Trypanosoma brucei zeta tubulin 0.0098 0.1531 0.4183
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0087 0.1353 0.3691
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0159 0.0583
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.023 0.0845
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.04
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.04
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.023 0.0627
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Trypanosoma cruzi epsilon tubulin, putative 0.0226 0.3639 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0069 0.0053
Echinococcus granulosus expressed conserved protein 0.0082 0.1266 0.1252
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0019 0.023 0.141
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0019 0.023 0.141
Loa Loa (eye worm) tubulin alpha 2 0.0128 0.2022 0.4668
Onchocerca volvulus 0.0006 0.0016 0.0031
Echinococcus granulosus cpg binding protein 0.0028 0.0381 0.0366
Brugia malayi Patched related family protein 4 0.0005 0.0001 0.0003
Echinococcus granulosus histone lysine methyltransferase setb 0.0038 0.0532 0.0516
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0069 0.0053
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0019 0.023 0.141
Schistosoma mansoni Smad4 0.0009 0.0069 0.0053
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0358 0.0826
Trypanosoma brucei beta tubulin 0.0226 0.3639 1
Echinococcus granulosus tubulin subunit TubB 0.0226 0.3639 0.3629
Schistosoma mansoni alpha tubulin 0.0226 0.3639 0.3629
Echinococcus granulosus tubulin alpha chain 0.0226 0.3639 0.3629
Leishmania major beta tubulin 0.0226 0.3639 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.023 0.0845
Trichomonas vaginalis tubulin alpha chain, putative 0.0128 0.2022 0.4242
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0006 0.0016 0.0052
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.023 0.0845
Schistosoma mansoni intermediate filament proteins 0.0048 0.0697 0.0682
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0145 0.0395
Brugia malayi tubulin alpha chain - mouse 0.0226 0.3639 0.8402
Giardia lamblia Alpha-tubulin 0.0226 0.3639 1
Onchocerca volvulus 0.0026 0.035 0.0735
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0019 0.023 0.141
Trichomonas vaginalis tubulin beta chain, putative 0.0226 0.3639 0.766
Schistosoma mansoni smad1 5 8 and 0.0009 0.0069 0.0053
Echinococcus granulosus Tubulin beta 2C chain 0.0226 0.3639 0.3629
Loa Loa (eye worm) hypothetical protein 0.0087 0.1353 0.3124
Echinococcus granulosus tubulin delta chain 0.0098 0.1531 0.1518
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.079 0.5105
Schistosoma mansoni hypothetical protein 0.0036 0.0509 0.0494
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0128 0.2022 0.4242
Schistosoma mansoni hypothetical protein 0.0036 0.0509 0.0494
Leishmania major alpha tubulin 0.0226 0.3639 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0226 0.3639 0.3629
Mycobacterium tuberculosis Probable lipase LipD 0.0026 0.035 0.1291
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Entamoeba histolytica acyl-coA synthetase, putative 0.0021 0.0261 0.0676
Schistosoma mansoni alpha tubulin 0.0226 0.3639 0.3629
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0014 0.0145 0.0357
Echinococcus multilocularis microtubule associated protein 2 0.0613 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0358 0.0826
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0006 0.0016 0.0052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0159 0.0583
Brugia malayi tubulin alpha-2 chain 0.0226 0.3639 0.8402
Brugia malayi CHE-14 protein 0.0038 0.0532 0.1228
Plasmodium vivax acyl-CoA synthetase, putative 0.0016 0.0173 0.0472
Trypanosoma cruzi tubulin delta chain 0.0098 0.1531 0.4183
Trichomonas vaginalis tubulin, putative 0.0128 0.2022 0.4242
Echinococcus granulosus dnaJ subfamily B 0.0382 0.6205 0.6199
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.023 0.0845
Toxoplasma gondii aldehyde dehydrogenase 0.0053 0.079 0.2167
Brugia malayi AMP-binding enzyme family protein 0.0006 0.0016 0.0037
Giardia lamblia Gamma tubulin 0.0226 0.3639 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0006 0.0016 0.004
Brugia malayi Isocitrate dehydrogenase 0.0014 0.0145 0.0335
Trichomonas vaginalis tubulin beta chain, putative 0.0128 0.2022 0.4242
Echinococcus multilocularis tubulin subunit TubB 0.0226 0.3639 0.3629
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0278 0.0641
Leishmania major alpha tubulin 0.0226 0.3639 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.023 0.0845
Trypanosoma cruzi zeta tubulin, putative 0.0098 0.1531 0.4183
Trypanosoma cruzi tubulin delta chain 0.0098 0.1531 0.4183
Echinococcus granulosus Tubulin beta 2C chain 0.0226 0.3639 0.3629
Brugia malayi Tubulin alpha-2 chain 0.0226 0.3639 0.8402
Schistosoma mansoni tubulin subunit alpha 0.0098 0.1531 0.1518
Onchocerca volvulus 0.0155 0.2468 0.5198
Brugia malayi hypothetical protein 0.0005 0.0001 0.0003
Trichomonas vaginalis tubulin beta chain, putative 0.0226 0.3639 0.766
Schistosoma mansoni aldehyde dehydrogenase 0.0053 0.079 0.0775
Leishmania major beta tubulin 0.0226 0.3639 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0261 0.0602
Plasmodium vivax SET domain protein, putative 0.0038 0.0532 0.1457
Echinococcus multilocularis tubulin delta chain 0.0098 0.1531 0.1518
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0226 0.3639 0.3629
Trypanosoma brucei epsilon tubulin 0.0226 0.3639 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0019 0.023 0.141
Echinococcus granulosus Tubulin alpha 1 chain 0.0226 0.3639 0.3629
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.023 0.059
Schistosoma mansoni tyrosine kinase 0.0079 0.1214 0.12
Echinococcus multilocularis peroxisome assembly protein 26 0.0226 0.3639 0.3629
Schistosoma mansoni beta-catenin 0.0118 0.1852 0.1839
Brugia malayi Tubulin gamma chain 0.0226 0.3639 0.8402
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0057 0.0856 0.0842
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.2191 0.5059
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0145 0.0129
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Echinococcus granulosus tubulin alpha chain 0.0226 0.3639 0.3629
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0048 0.0697 0.161
Echinococcus multilocularis Tubulin beta 2C chain 0.0226 0.3639 0.3629
Schistosoma mansoni hypothetical protein 0.0036 0.0509 0.0494
Entamoeba histolytica tubulin alpha chain, putative 0.0226 0.3639 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0226 0.3639 0.766
Brugia malayi Pre-SET motif family protein 0.0258 0.4161 0.9606
Schistosoma mansoni hypothetical protein 0.0382 0.6205 0.6199
Echinococcus granulosus tubulin beta 4A class IVa 0.0226 0.3639 0.3629
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Schistosoma mansoni alpha tubulin 0.0226 0.3639 0.3629
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0023 0.0292 0.0277
Plasmodium falciparum tubulin epsilon chain, putative 0.0226 0.3639 1
Onchocerca volvulus 0.001 0.0072 0.0148
Echinococcus granulosus alpha tubulin 0.0226 0.3639 0.3629
Loa Loa (eye worm) tubulin alpha-2 chain 0.0226 0.3639 0.8402
Echinococcus granulosus Tubulin beta 2C chain 0.0226 0.3639 0.3629
Leishmania major beta tubulin 0.0226 0.3639 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0038 0.0532 0.0516
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0787 0.0772
Echinococcus granulosus Tubulin beta 2C chain 0.0226 0.3639 0.3629
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0787 0.1818
Schistosoma mansoni tubulin subunit beta 0.0226 0.3639 0.3629
Mycobacterium ulcerans cell division protein FtsZ 0.0098 0.1531 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0026 0.035 0.1291
Trypanosoma brucei alpha tubulin 0.0226 0.3639 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Leishmania major beta tubulin 0.0226 0.3639 1
Echinococcus granulosus Tubulin beta 2C chain 0.0226 0.3639 0.3629
Onchocerca volvulus 0.0268 0.4331 0.9126
Onchocerca volvulus 0.0048 0.0697 0.1466
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.1531 0.3206
Echinococcus granulosus Tubulin alpha 1 chain 0.0226 0.3639 0.3629
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.06 0.0585
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0787 0.0772
Echinococcus granulosus tubulin beta 1 chain 0.0226 0.3639 0.3629
Schistosoma mansoni tubulin subunit beta 0.0226 0.3639 0.3629
Brugia malayi Tubulin alpha-2 chain 0.0226 0.3639 0.8402
Schistosoma mansoni cytochrome P450 0.0019 0.023 0.0214
Leishmania major alpha tubulin 0.0226 0.3639 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0053 0.079 0.292
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0006 0.0016 0.004
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Schistosoma mansoni aldehyde dehydrogenase 0.0053 0.079 0.0775
Schistosoma mansoni tubulin subunit beta 0.0226 0.3639 0.3629
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Echinococcus granulosus tubulin alpha 3 chain 0.0226 0.3639 0.3629
Echinococcus multilocularis tubulin alpha chain 0.0226 0.3639 0.3629
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0069 0.0053
Plasmodium vivax tubulin gamma chain, putative 0.0226 0.3639 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0098 0.1531 0.4206
Brugia malayi AMP-binding enzyme family protein 0.0006 0.0016 0.0037
Echinococcus granulosus pangolin 0.0057 0.0856 0.0842
Echinococcus multilocularis tubulin alpha chain 0.0226 0.3639 0.3629
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0159 0.0583
Leishmania major beta tubulin 0.0226 0.3639 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0226 0.3639 0.3629
Echinococcus granulosus beta catenin 0.0118 0.1852 0.1839
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0006 0.0016 0.0052
Echinococcus multilocularis Niemann Pick C1 protein 0.0125 0.1971 0.1958
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.023 0.0845
Brugia malayi Patched related family protein 10 0.0005 0.0001 0.0003
Plasmodium falciparum acyl-CoA synthetase 0.0016 0.0173 0.0472
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.023 0.0845
Loa Loa (eye worm) hypothetical protein 0.0268 0.4331 1
Leishmania major alpha tubulin 0.0226 0.3639 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Schistosoma mansoni cpg binding protein 0.0027 0.0356 0.0341
Echinococcus granulosus Niemann Pick C1 protein 0.0125 0.1971 0.1958
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Echinococcus multilocularis beta LACTamase domain containing family member 0.0026 0.035 0.0335
Echinococcus granulosus Protein patched homolog 1 0.0038 0.0532 0.0517
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0069 0.0053
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0098 0.1531 0.3206
Echinococcus granulosus tubulin alpha 0.0226 0.3639 0.3629
Toxoplasma gondii ABC1 family protein 0.0026 0.035 0.0959
Schistosoma mansoni hypothetical protein 0.0433 0.7049 0.7045
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0261 0.0602
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0019 0.023 0.141
Echinococcus multilocularis Tubulin alpha 1 chain 0.0226 0.3639 0.3629
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0019 0.023 0.141
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0053 0.079 0.0775
Loa Loa (eye worm) hypothetical protein 0.0026 0.035 0.0809
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Schistosoma mansoni patched 1 0.0038 0.0532 0.0517
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.023 0.0845
Schistosoma mansoni cpg binding protein 0.0028 0.0381 0.0366
Plasmodium falciparum alpha tubulin 2 0.0226 0.3639 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0019 0.023 0.141
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0014 0.0145 0.0129
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.035 0.071
Echinococcus multilocularis tubulin beta 1 chain 0.0226 0.3639 0.3629
Loa Loa (eye worm) cytochrome P450 0.0019 0.023 0.053
Trichomonas vaginalis tubulin gamma chain, putative 0.0226 0.3639 0.766
Trichomonas vaginalis tubulin beta chain, putative 0.0226 0.3639 0.766
Leishmania major alpha tubulin 0.0226 0.3639 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.035 0.0809
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0019 0.023 0.141
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Mycobacterium tuberculosis Conserved protein 0.0026 0.035 0.1291
Toxoplasma gondii alpha-tubulin I, putative 0.0226 0.3639 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0006 0.0016 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.035 0.0809
Schistosoma mansoni smad1 5 8 and 0.0009 0.0069 0.0053
Echinococcus granulosus peroxisome assembly protein 26 0.0226 0.3639 0.3629
Brugia malayi Intermediate filament tail domain containing protein 0.0048 0.0697 0.161
Echinococcus multilocularis sterol regulatory element binding protein 0.0038 0.0532 0.0517
Brugia malayi beta-tubulin, identical 0.0226 0.3639 0.8402
Leishmania major beta tubulin 0.0226 0.3639 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0261 0.0676
Schistosoma mansoni hypothetical protein 0.0433 0.7049 0.7045
Loa Loa (eye worm) tubulin alpha 2 0.0128 0.2022 0.4668
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0026 0.035 0.1291
Echinococcus granulosus geminin 0.0433 0.7049 0.7045
Brugia malayi isocitrate dehydrogenase 0.0014 0.0145 0.0335
Loa Loa (eye worm) hypothetical protein 0.0046 0.0671 0.1548
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0046 0.003
Brugia malayi Pre-SET motif family protein 0.0038 0.0532 0.1227
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0073 0.0057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0787 0.1816
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.023 0.0845
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0026 0.035 0.0809
Echinococcus multilocularis protein pangolin J 0.0057 0.0856 0.0842
Entamoeba histolytica tubulin family protein 0.0226 0.3639 1
Loa Loa (eye worm) alpha-tubulin 0.0226 0.3639 0.8402
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0019 0.023 0.141
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0038 0.0532 0.0516
Schistosoma mansoni hypothetical protein 0.0036 0.0509 0.0494
Trypanosoma brucei beta tubulin 0.0226 0.3639 1
Brugia malayi Tubulin alpha chain 0.0226 0.3639 0.8402
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0071 0.0165
Trichomonas vaginalis tubulin epsilon chain, putative 0.0226 0.3639 0.766
Schistosoma mansoni tubulin subunit alpha 0.0226 0.3639 0.3629
Brugia malayi hypothetical protein 0.0085 0.1319 0.3045
Brugia malayi cytoplasmic intermediate filament protein 0.0025 0.0334 0.077
Loa Loa (eye worm) beta-tubulin 0.0226 0.3639 0.8402
Echinococcus granulosus survival motor neuron protein 1 0.0085 0.1319 0.1305
Trichomonas vaginalis antibiotic synthetase, putative 0.0006 0.0016 0.0003
Echinococcus multilocularis survival motor neuron protein 1 0.0085 0.1319 0.1305
Giardia lamblia Beta tubulin 0.0226 0.3639 1
Schistosoma mansoni tubulin subunit gamma 0.0226 0.3639 0.3629
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.023 0.059
Loa Loa (eye worm) hypothetical protein 0.0026 0.035 0.0809
Leishmania major beta tubulin 0.0226 0.3639 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0006 0.0016 0.0052
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0016 0.0037
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.023 0.0214
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0258 0.4161 0.9606
Schistosoma mansoni hypothetical protein 0.0019 0.023 0.0214
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.023 0.059
Brugia malayi hypothetical protein 0.0155 0.2468 0.5697
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0019 0.023 0.141
Leishmania major beta tubulin 0.0226 0.3639 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0069 0.016
Trypanosoma brucei alpha tubulin, putative 0.0128 0.2022 0.5536
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.023 0.0845
Leishmania major epsilon tubulin, putative 0.0226 0.3639 1
Echinococcus granulosus intermediate filament protein 0.0048 0.0697 0.0682
Loa Loa (eye worm) hypothetical protein 0.0155 0.2468 0.5697
Echinococcus multilocularis Tubulin beta 2C chain 0.0226 0.3639 0.3629
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0532 0.0516
Echinococcus granulosus Tubulin alpha 1 chain 0.0226 0.3639 0.3629
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0261 0.1615
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0026 0.035 0.2206
Onchocerca volvulus 0.0038 0.0532 0.1117
Loa Loa (eye worm) tubulin alpha chain 0.0226 0.3639 0.8402
Echinococcus multilocularis isocitrate dehydrogenase 0.0014 0.0145 0.0129
Giardia lamblia Beta tubulin 0.0226 0.3639 1
Leishmania major delta tubulin, putative 0.0098 0.1531 0.4183
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0014 0.0145 0.0357
Trichomonas vaginalis penicillin-binding protein, putative 0.0026 0.035 0.071
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0261 0.0676
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0006 0.0016 0.004
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.04
Onchocerca volvulus 0.005 0.0745 0.1567
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.0042 0.06 0.1613
Echinococcus multilocularis dnaJ subfamily B 0.0382 0.6205 0.6199
Mycobacterium tuberculosis Conserved protein 0.0026 0.035 0.1291
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0017 0.0201 0.0463
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0016 0.0173 0.0635
Trichomonas vaginalis tubulin alpha chain, putative 0.0128 0.2022 0.4242
Trypanosoma brucei epsilon tubulin 0.0226 0.3639 1
Mycobacterium leprae putative cytochrome p450 0.0019 0.023 0.141
Brugia malayi protein C24B5.3 0.0005 0.0001 0.0003
Toxoplasma gondii propionate-CoA ligase 0.0006 0.0016 0.004
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0006 0.0016 0.0052
Echinococcus multilocularis beta tubulin 0.0226 0.3639 0.3629
Echinococcus multilocularis expressed conserved protein 0.0082 0.1266 0.1252
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0019 0.023 0.141
Echinococcus multilocularis tyrosine protein kinase shark 0.0079 0.1214 0.12
Echinococcus granulosus tubulin alpha 1C chain 0.0226 0.3639 0.3629
Trypanosoma cruzi beta tubulin, putative 0.0226 0.3639 1
Leishmania major beta tubulin 0.0226 0.3639 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0006 0.0016 0.0052
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Leishmania major beta tubulin 0.0226 0.3639 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0019 0.023 0.141
Mycobacterium tuberculosis Conserved protein 0.0026 0.035 0.1291
Trichomonas vaginalis tubulin beta chain, putative 0.0226 0.3639 0.766
Echinococcus multilocularis tubulin alpha 0.0226 0.3639 0.3629
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Brugia malayi hypothetical protein 0.0005 0.0001 0.0003
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0014 0.0145 0.0129
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.023 0.0845
Loa Loa (eye worm) patched family protein 0.0005 0.0001 0.0003
Onchocerca volvulus 0.0006 0.0016 0.0031
Echinococcus granulosus tubulin alpha chain 0.0226 0.3639 0.3629
Leishmania major alpha tubulin 0.0226 0.3639 1
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Loa Loa (eye worm) tubulin gamma chain 0.0226 0.3639 0.8402
Brugia malayi alpha-tubulin 0.0226 0.3639 0.8402
Echinococcus granulosus sterol regulatory element binding protein 0.0038 0.0532 0.0517
Leishmania major beta tubulin 0.0226 0.3639 1
Brugia malayi AMP-binding enzyme family protein 0.0006 0.0016 0.0037
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.023 0.0845
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0053 0.079 0.2135
Plasmodium vivax tubulin alpha chain, putative 0.0226 0.3639 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.3639 0.8402
Echinococcus granulosus Niemann Pick C1 protein 0.0087 0.1353 0.1339
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0226 0.3639 0.766
Loa Loa (eye worm) tubulin alpha-3 chain 0.0098 0.1531 0.3536
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.079 0.5105
Trichomonas vaginalis tubulin alpha chain, putative 0.0128 0.2022 0.4242
Trichomonas vaginalis tubulin beta chain, putative 0.0226 0.3639 0.766
Echinococcus multilocularis tubulin subunit beta 0.0226 0.3639 0.3629
Echinococcus multilocularis geminin 0.0433 0.7049 0.7045
Brugia malayi Niemann-Pick C1 protein precursor 0.0087 0.1353 0.3124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0006 0.0016 0.0052
Trichomonas vaginalis tubulin epsilon chain, putative 0.0226 0.3639 0.766
Mycobacterium leprae Conserved hypothetical protein 0.0019 0.023 0.141
Echinococcus granulosus tubulin epsilon chain 0.0226 0.3639 0.3629
Mycobacterium ulcerans esterase/lipase LipP 0.0026 0.035 0.2206
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0014 0.0145 0.0395
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0016 0.0173 0.5
Leishmania major cytochrome p450-like protein 0.0019 0.023 0.059
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0261 0.1615
Entamoeba histolytica acyl-CoA synthetase, putative 0.0021 0.0261 0.0676
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0787 0.0772
Entamoeba histolytica hypothetical protein 0.0042 0.06 0.1613
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0128 0.2022 0.4242
Echinococcus granulosus tubulin alpha 3 chain 0.0226 0.3639 0.3629
Loa Loa (eye worm) beta-lactamase 0.0026 0.035 0.0809
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0046 0.003
Schistosoma mansoni cpg binding protein 0.0028 0.0381 0.0366
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0261 0.1615
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Leishmania major alpha tubulin 0.0226 0.3639 1
Echinococcus granulosus tubulin alpha chain 0.0226 0.3639 0.3629
Loa Loa (eye worm) hypothetical protein 0.0048 0.0697 0.161
Mycobacterium tuberculosis Probable hydrolase 0.0026 0.035 0.1291
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0261 0.0602
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0261 0.1615
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0021 0.0261 0.1615
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.023 0.0845
Leishmania major alpha tubulin 0.0226 0.3639 1
Echinococcus multilocularis 0.0019 0.023 0.0214
Echinococcus granulosus Smad4 0.0009 0.0069 0.0053
Loa Loa (eye worm) tubulin alpha chain 0.0226 0.3639 0.8402
Echinococcus granulosus lamin 0.0048 0.0697 0.0682
Onchocerca volvulus 0.0026 0.035 0.0735
Onchocerca volvulus 0.0294 0.4746 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.023 0.059
Leishmania major beta tubulin 0.0226 0.3639 1
Loa Loa (eye worm) tubulin beta chain 0.0098 0.1531 0.3536
Plasmodium vivax tubulin alpha chain, putative 0.0226 0.3639 1
Trypanosoma cruzi alpha tubulin, putative 0.0226 0.3639 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0069 0.0053
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Echinococcus multilocularis tubulin alpha 3 chain 0.0226 0.3639 0.3629
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.023 0.0845
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0098 0.1531 0.4206
Onchocerca volvulus Cirhin homolog 0.0117 0.1839 0.3873
Leishmania major cytochrome p450-like protein 0.0027 0.0358 0.0943
Echinococcus multilocularis tubulin epsilon chain 0.0226 0.3639 0.3629
Giardia lamblia Beta tubulin 0.0226 0.3639 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.023 0.0845
Leishmania major alpha tubulin 0.0226 0.3639 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0128 0.2022 0.4668
Echinococcus multilocularis Tubulin beta 2C chain 0.0226 0.3639 0.3629
Schistosoma mansoni smad 0.0009 0.0069 0.0053
Loa Loa (eye worm) tubulin beta-4 chain 0.0226 0.3639 0.8402
Echinococcus multilocularis Smad4 0.0009 0.0069 0.0053
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0014 0.0145 0.0531
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.2191 0.5059
Mycobacterium ulcerans hypothetical protein 0.0026 0.035 0.2206
Onchocerca volvulus 0.0006 0.0016 0.0031
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Trichomonas vaginalis tubulin epsilon chain, putative 0.0098 0.1531 0.3206
Brugia malayi beta-lactamase family protein 0.0026 0.035 0.0809
Echinococcus multilocularis lamin 0.0048 0.0697 0.0682
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0017 0.0201 0.0185
Echinococcus granulosus beta tubulin 0.0226 0.3639 0.3629
Loa Loa (eye worm) tubulin beta-2A chain 0.0226 0.3639 0.8402
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0019 0.023 0.141
Schistosoma mansoni pangolin 0.0057 0.0856 0.0842
Trypanosoma brucei tubulin gamma chain 0.0226 0.3639 1
Entamoeba histolytica hypothetical protein 0.0042 0.06 0.1613
Brugia malayi Cytochrome P450 family protein 0.0019 0.023 0.053
Leishmania major cytochrome p450-like protein 0.0019 0.023 0.059
Echinococcus granulosus smad 0.0009 0.0069 0.0053
Loa Loa (eye worm) hypothetical protein 0.0085 0.1319 0.3045
Toxoplasma gondii beta-tubulin, putative 0.0226 0.3639 1
Loa Loa (eye worm) BEN-1 protein 0.0226 0.3639 0.8402
Loa Loa (eye worm) oxidoreductase 0.0006 0.0016 0.0037
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0787 0.1816
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0006 0.0016 0.0037
Trypanosoma cruzi zeta tubulin, putative 0.0098 0.1531 0.4183
Echinococcus granulosus tubulin alpha chain 0.0226 0.3639 0.3629
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0261 0.0676
Leishmania major alpha tubulin 0.0226 0.3639 1
Leishmania major beta tubulin 0.0226 0.3639 1
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.035 0.071
Trichomonas vaginalis tubulin, putative 0.0226 0.3639 0.766
Echinococcus multilocularis tubulin alpha chain 0.0226 0.3639 0.3629
Echinococcus multilocularis protein patched 0.0038 0.0532 0.0517
Entamoeba histolytica acyl-CoA synthetase, putative 0.0021 0.0261 0.0676
Schistosoma mansoni tubulin subunit alpha 0.0226 0.3639 0.3629
Schistosoma mansoni tubulin subunit delta 0.0098 0.1531 0.1518
Echinococcus multilocularis beta catenin 0.0118 0.1852 0.1839
Loa Loa (eye worm) hypothetical protein 0.0008 0.0042 0.0098
Brugia malayi protein C24B5.3 0.0005 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0155 0.2468 0.5697
Schistosoma mansoni lamin 0.0048 0.0697 0.0682
Trypanosoma brucei alpha tubulin 0.0226 0.3639 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.04
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0019 0.023 0.141
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0021 0.0261 0.1615
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0019 0.023 0.141
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0118 0.1852 0.4275
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0261 0.096
Brugia malayi Smad1 0.0009 0.0069 0.016
Leishmania major hypothetical protein, conserved 0.0026 0.035 0.0923
Loa Loa (eye worm) hypothetical protein 0.005 0.0745 0.172
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Brugia malayi MH2 domain containing protein 0.0009 0.0069 0.016
Plasmodium falciparum tubulin beta chain 0.0226 0.3639 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0226 0.3639 0.3629
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.035 0.0923
Loa Loa (eye worm) hypothetical protein 0.0038 0.0532 0.1228
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0532 0.0516
Trichomonas vaginalis tubulin beta chain, putative 0.0226 0.3639 0.766
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.023 0.0845
Loa Loa (eye worm) hypothetical protein 0.0021 0.0261 0.0602
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Schistosoma mansoni survival motor neuron protein 0.0017 0.0201 0.0185
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.023 0.0845
Plasmodium falciparum tubulin gamma chain 0.0226 0.3639 1
Plasmodium vivax hypothetical protein, conserved 0.0026 0.035 0.0959
Entamoeba histolytica tubulin alpha-1 chain 0.0226 0.3639 1
Trypanosoma brucei epsilon tubulin 0.0226 0.3639 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Brugia malayi Cytochrome P450 family protein 0.0027 0.0358 0.0826
Brugia malayi CXXC zinc finger family protein 0.0027 0.0356 0.0822
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Loa Loa (eye worm) HMP-2 protein 0.0118 0.1852 0.4275
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.0874 0.0859
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0057 0.0856 0.0842
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0053 0.079 0.0775
Onchocerca volvulus 0.0021 0.0261 0.0546
Echinococcus granulosus tubulin subunit beta 0.0226 0.3639 0.3629
Mycobacterium ulcerans beta-lactamase 0.0026 0.035 0.2206
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0356 0.0822
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Loa Loa (eye worm) tubulin beta-1 chain 0.0226 0.3639 0.8402
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0261 0.1615
Toxoplasma gondii histone lysine methyltransferase SET1 0.0052 0.0773 0.2122
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0145 0.0357
Mycobacterium tuberculosis Cell division protein FtsZ 0.0098 0.1531 0.5669
Toxoplasma gondii beta-1 tubulin, putative 0.0226 0.3639 1
Loa Loa (eye worm) alpha-tubulin 0.0226 0.3639 0.8402
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0358 0.0826
Leishmania major beta tubulin 0.0226 0.3639 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0006 0.0016 0.0052
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0261 0.1615
Treponema pallidum cell division protein FtsZ 0.0098 0.1531 0.5
Brugia malayi hypothetical protein 0.0005 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Echinococcus granulosus beta tubulin 0.0226 0.3639 0.3629
Trichomonas vaginalis tubulin, putative 0.0128 0.2022 0.4242
Echinococcus granulosus tubulin gamma 1 chain 0.0226 0.3639 0.3629
Trichomonas vaginalis tubulin alpha chain, putative 0.0226 0.3639 0.766
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0145 0.0395
Plasmodium vivax tubulin beta chain, putative 0.0226 0.3639 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0226 0.3639 0.3629
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0026 0.035 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.1531 0.3206
Echinococcus granulosus beta LACTamase domain containing family member 0.0026 0.035 0.0335
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0021 0.0261 0.096
Echinococcus multilocularis protein dispatched 1 0.0043 0.0619 0.0604
Loa Loa (eye worm) hypothetical protein 0.0098 0.1531 0.3536
Mycobacterium leprae conserved hypothetical protein 0.0026 0.035 0.2206
Brugia malayi beta-lactamase family protein 0.0026 0.035 0.0809
Echinococcus multilocularis smad 0.0009 0.0069 0.0053
Trypanosoma cruzi tubulin gamma chain 0.0226 0.3639 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0261 0.0602
Echinococcus multilocularis Tubulin alpha 1 chain 0.0226 0.3639 0.3629
Mycobacterium tuberculosis Probable esterase LipL 0.0026 0.035 0.1291
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.005 0.0745 0.172
Schistosoma mansoni tubulin subunit beta 0.0098 0.1531 0.1518
Leishmania major beta tubulin 0.0226 0.3639 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.023 0.0845
Brugia malayi HMG box family protein 0.0057 0.0856 0.1977
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0014 0.0145 0.0129
Loa Loa (eye worm) patched family protein 0.0005 0.0001 0.0003
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0038 0.0532 0.1228
Brugia malayi Tubulin alpha chain 0.0098 0.1531 0.3536
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0169 0.27 1
Brugia malayi beta-lactamase 0.0026 0.035 0.0809
Echinococcus granulosus lamin dm0 0.0048 0.0697 0.0682
Brugia malayi hypothetical protein 0.0005 0.0001 0.0003
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0069 0.016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.079 0.5105
Echinococcus multilocularis tubulin alpha 1C chain 0.0226 0.3639 0.3629
Echinococcus multilocularis tubulin alpha chain 0.0226 0.3639 0.3629
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0261 0.1615
Loa Loa (eye worm) patched family protein 0.0005 0.0001 0.0003
Toxoplasma gondii beta tubulin 0.0226 0.3639 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.035 0.0809
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0026 0.035 0.0335
Trypanosoma brucei zeta tubulin, putative 0.0098 0.1531 0.4183
Schistosoma mansoni tubulin subunit alpha 0.0226 0.3639 0.3629
Onchocerca volvulus 0.0048 0.0697 0.1466
Trypanosoma brucei alpha tubulin 0.0226 0.3639 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0145 0.0357
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0073 0.0057
Brugia malayi intermediate filament protein 0.0048 0.0697 0.161
Loa Loa (eye worm) histone methyltransferase 0.001 0.0073 0.0169
Leishmania major alpha tubulin 0.0226 0.3639 1
Echinococcus multilocularis lamin dm0 0.0048 0.0697 0.0682
Loa Loa (eye worm) hypothetical protein 0.0026 0.035 0.0809
Loa Loa (eye worm) patched family protein 0.0005 0.0001 0.0003
Brugia malayi Patched related family protein 12 0.0005 0.0001 0.0003
Echinococcus multilocularis tubulin alpha 1C chain 0.0226 0.3639 0.3629
Trichomonas vaginalis esterase, putative 0.0026 0.035 0.071
Schistosoma mansoni tubulin subunit beta 0.0226 0.3639 0.3629
Leishmania major alpha tubulin 0.0226 0.3639 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0226 0.3639 1
Brugia malayi Patched protein homolog 1 0.0005 0.0001 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.035 0.071
Echinococcus granulosus tyrosine protein kinase shark 0.0079 0.1214 0.12
Trypanosoma brucei beta tubulin 0.0226 0.3639 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0016 0.0173 0.1037
Plasmodium falciparum alpha tubulin 1 0.0226 0.3639 1
Brugia malayi MH1 domain containing protein 0.0009 0.0069 0.016
Plasmodium vivax acetyl-CoA synthetase, putative 0.0006 0.0016 0.004
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0038 0.0532 0.1457
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0006 0.0016 0.0037
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0358 0.0943
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0358 0.0943
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0787 0.0772
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0006 0.0016 0.0052
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0358 0.2255
Entamoeba histolytica tubulin family protein 0.0226 0.3639 1
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.035 0.0923
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0006 0.0016 0.0052
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0014 0.0145 0.0395
Leishmania major gamma-tubulin 0.0226 0.3639 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0087 0.1353 0.1339
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0037
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0023 0.0292 0.0277
Trichomonas vaginalis set domain proteins, putative 0.0294 0.4746 1
Loa Loa (eye worm) Smad1 0.0009 0.0069 0.016
Schistosoma mansoni hypothetical protein 0.0042 0.06 0.0585
Echinococcus multilocularis Tubulin beta 2C chain 0.0226 0.3639 0.3629
Schistosoma mansoni lamin 0.0048 0.0697 0.0682
Trichomonas vaginalis penicillin-binding protein, putative 0.0026 0.035 0.071
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.035 0.0923
Onchocerca volvulus 0.0017 0.0201 0.042
Mycobacterium ulcerans lipase LipD 0.0026 0.035 0.2206
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0019 0.023 0.141
Brugia malayi hypothetical protein 0.0042 0.06 0.1386
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0038 0.0532 0.1227
Brugia malayi Cytochrome P450 family protein 0.0053 0.0787 0.1818
Onchocerca volvulus 0.0128 0.2022 0.4258
Loa Loa (eye worm) isocitrate dehydrogenase 0.0014 0.0145 0.0335
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0787 0.0772
Brugia malayi Cytochrome P450 family protein 0.0027 0.0358 0.0826
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0006 0.0016 0.0052
Trypanosoma brucei tubulin delta chain 0.0098 0.1531 0.4183
Loa Loa (eye worm) hypothetical protein 0.0047 0.0683 0.1577
Trypanosoma brucei beta tubulin 0.0226 0.3639 1
Echinococcus multilocularis hypothetical protein 0.0226 0.3639 0.3629
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0046 0.003
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0787 0.0772
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.04
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.06 0.0585
Trichomonas vaginalis tubulin epsilon chain, putative 0.0226 0.3639 0.766
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0069 0.0053
Trichomonas vaginalis tubulin alpha chain, putative 0.0226 0.3639 0.766
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0098 0.1531 0.5
Leishmania major beta tubulin 0.0226 0.3639 1
Brugia malayi MH1 domain containing protein 0.0009 0.0069 0.016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0261 0.0602
Schistosoma mansoni hypothetical protein 0.0208 0.3345 0.3334
Giardia lamblia Alpha-tubulin 0.0226 0.3639 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0046 0.003
Trypanosoma cruzi epsilon tubulin, putative 0.0226 0.3639 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0019 0.023 0.141
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0145 0.0129
Trichomonas vaginalis tubulin gamma chain, putative 0.0226 0.3639 0.766
Plasmodium falciparum tubulin delta chain, putative 0.0098 0.1531 0.4206
Trichomonas vaginalis tubulin, putative 0.0098 0.1531 0.3206
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Mycobacterium leprae Probable lipase LipE 0.0026 0.035 0.2206
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0145 0.0129
Leishmania major beta tubulin 0.0226 0.3639 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0025 0.0334 0.077
Brugia malayi Tubulin beta-1 chain 0.0226 0.3639 0.8402
Echinococcus granulosus tubulin alpha 1C chain 0.0226 0.3639 0.3629
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0006 0.0016 0.0037
Trypanosoma brucei beta tubulin 0.0226 0.3639 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.023 0.0845
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0098 0.1531 0.3206
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003
Brugia malayi Tubulin beta chain 0.0098 0.1531 0.3536
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0006 0.0016 0.0037
Trichomonas vaginalis tubulin gamma chain, putative 0.0098 0.1531 0.3206
Brugia malayi MH2 domain containing protein 0.0138 0.2191 0.5059
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0532 0.1093
Brugia malayi Patched family protein 0.0005 0.0001 0.0003
Toxoplasma gondii alpha tubulin TUBA1 0.0226 0.3639 1
Mycobacterium tuberculosis Probable lipase LipE 0.0026 0.035 0.1291
Echinococcus multilocularis beta tubulin 0.0226 0.3639 0.3629
Brugia malayi MH2 domain containing protein 0.0009 0.0069 0.016
Trichomonas vaginalis tubulin beta chain, putative 0.0226 0.3639 0.766
Leishmania major beta tubulin 0.0226 0.3639 1
Leishmania major zeta tubulin, putative 0.0098 0.1531 0.4183
Brugia malayi cytochrome P450 0.0019 0.023 0.053
Schistosoma mansoni tubulin subunit beta 0.0226 0.3639 0.3629
Loa Loa (eye worm) hypothetical protein 0.0022 0.0278 0.0641
Loa Loa (eye worm) tubulin beta chain 0.0226 0.3639 0.8402
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0787 0.0772
Onchocerca volvulus 0.0027 0.0356 0.0747
Mycobacterium ulcerans hypothetical protein 0.0021 0.0261 0.1615
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0003

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.008 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by two fold serial dilution method ChEMBL. 22079379
MIC (functional) = 4 ug ml-1 Antibacterial activity against Escherichia coli 10-2 after 18 hrs by two fold serial dilution method ChEMBL. 22079379
MIC (functional) = 8 ug ml-1 Antibacterial activity against Escherichia coli 10-3 after 18 hrs by two fold serial dilution method ChEMBL. 22079379
MIC (functional) = 32 ug ml-1 Antibacterial activity against Escherichia coli 09-1 after 18 hrs by two fold serial dilution method ChEMBL. 22079379
MIC (functional) = 64 ug ml-1 Antibacterial activity against Escherichia coli 09-3 after 18 hrs by two fold serial dilution method ChEMBL. 22079379
MIC (functional) > 128 ug ml-1 Antibacterial activity against Escherichia coli 09-2 after 18 hrs by two fold serial dilution method ChEMBL. 22079379
MIC (functional) > 128 ug ml-1 Antibacterial activity against Escherichia coli 10-1 after 18 hrs by two fold serial dilution method ChEMBL. 22079379

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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