Detailed information for compound 288460

Basic information

Technical information
  • TDR Targets ID: 288460
  • Name: N-[6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-( 4-methylphenyl)-2-propylpyrimidin-4-yl]-4-ter t-butylbenzenesulfonamide
  • MW: 640.591 | Formula: C30H34BrN5O4S
  • H donors: 1 H acceptors: 6 LogP: 7.19 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCc1nc(OCCOc2ncc(cn2)Br)c(c(n1)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)C
  • InChi: 1S/C30H34BrN5O4S/c1-6-7-25-34-27(36-41(37,38)24-14-12-22(13-15-24)30(3,4)5)26(21-10-8-20(2)9-11-21)28(35-25)39-16-17-40-29-32-18-23(31)19-33-29/h8-15,18-19H,6-7,16-17H2,1-5H3,(H,34,35,36)
  • InChiKey: BHSAHNPXJBATRX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-2-propyl-5-(p-tolyl)pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide
  • N-[6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-2-propyl-5-(p-tolyl)-4-pyrimidinyl]-4-tert-butylbenzenesulfonamide
  • N-[6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(4-methylphenyl)-2-propyl-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide
  • N-[6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-5-(4-methylphenyl)-2-propyl-4-pyrimidinyl]-4-tert-butylbenzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Endothelin receptor ET-A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0086 0.0191 0.0947
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0025 0.0715
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0025 0.0715
Schistosoma mansoni sugar transporter 0.0038 0.0069 0.0341
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0015 0.0091
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0088 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0012 0.0073
Trypanosoma brucei polo-like protein kinase 0.0111 0.0255 0.7335
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0154 0.0764
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0008 0.004
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0013 0.0007 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0025 0.0025
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.001 0.0122
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.0015 0.0178
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0013 0.0007 0.0034
Echinococcus multilocularis calpain A 0.0079 0.0173 0.086
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Schistosoma mansoni netrin receptor unc5 0.0017 0.0015 0.0076
Trypanosoma brucei calpain-like protein, putative 0.0022 0.003 0.085
Echinococcus multilocularis hypothetical protein 0.0013 0.0007 0.0034
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0408
Echinococcus granulosus synaptic vesicle 2 protein 0.0038 0.0069 0.0228
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0025 0.0025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0013 0.0007 0.0034
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0038 0.0069 0.0341
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0082 0.0408
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0013 0.0007 0.0034
Loa Loa (eye worm) calpain 0.0022 0.003 0.0176
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0082 0.2366
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0014 0.04
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0114 0.136
Echinococcus granulosus abhydrolase domain containing protein 0.0044 0.0085 0.0279
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0283
Echinococcus granulosus Ankyrin 0.0017 0.0016 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0255 0.3045
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0126 0.362
Trichomonas vaginalis myo-inositol transporter, putative 0.0038 0.0069 0.082
Loa Loa (eye worm) calpain family protein 1 0.0075 0.0163 0.0972
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0013 0.0007 0.0034
Onchocerca volvulus 0.0038 0.0069 0.1019
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.001 0.0122
Brugia malayi major facilitator superfamily protein 0.0038 0.0069 0.0408
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0082 0.2366
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.082
Brugia malayi calpain family protein 1 0.0075 0.0163 0.0972
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0073
Leishmania major protein kinase, putative 0.0016 0.0014 0.04
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0111 0.0255 0.084
Brugia malayi N-terminal motif family protein 0.0211 0.0507 0.3014
Onchocerca volvulus Serine\/threonine kinase homolog 0.0111 0.0255 0.3784
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.0838 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0048
Echinococcus multilocularis solute carrier family 22 0.0038 0.0069 0.0341
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0126 0.0292 0.0874
Mycobacterium ulcerans recombinase A 0.0126 0.0292 0.2617
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.001 0.0122
Onchocerca volvulus 0.0038 0.0069 0.1019
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0013 0.0007 0.0034
Loa Loa (eye worm) protein-tyrosine phosphatase 0.053 0.1316 0.7825
Giardia lamblia Sugar-proton symporter 0.0038 0.0069 0.082
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0069 0.1975
Toxoplasma gondii sugar transporter ST3 0.0038 0.0069 0.5456
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0043 0.0385
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0099 0.0326
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0043 0.1237
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0061 0.4859
Schistosoma mansoni multidrug resistance protein 0.0017 0.0015 0.0074
Brugia malayi hypothetical protein 0.0014 0.0008 0.0048
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0069 0.1975
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0043 0.0385
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.082
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0013 0.0007 0.0034
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0114 0.136
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0126 0.0625
Brugia malayi acetyltransferase, GNAT family protein 0.0169 0.0402 0.2388
Onchocerca volvulus 0.0013 0.0007 0.0102
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0148 0.0348 1
Echinococcus multilocularis calpain 7 (C02 family) 0.0022 0.003 0.0147
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0048 0.0283
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0099 0.1181
Schistosoma mansoni calpain-7 (C02 family) 0.0026 0.0038 0.0191
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Brugia malayi Protein-tyrosine phosphatase containing protein 0.053 0.1316 0.7825
Onchocerca volvulus 0.0013 0.0007 0.0102
Schistosoma mansoni hypothetical protein 0.0021 0.0025 0.0123
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0126 0.1503
Brugia malayi nuclear receptor NHR-67 0.0014 0.0008 0.0048
Brugia malayi Protein-tyrosine phosphatase 1 0.0013 0.0007 0.0041
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0043 0.0513
Onchocerca volvulus 0.0013 0.0007 0.0102
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.003 0.085
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0012 0.0073
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0008 0.004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0043 0.0129
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.001 0.0034
Echinococcus multilocularis multidrug resistance associated protein 1 0.0017 0.0015 0.0074
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0013 0.0007 0.0199
Onchocerca volvulus 0.0017 0.0016 0.0242
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0048 0.0236
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0043 0.0385
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0408
Onchocerca volvulus 0.0013 0.0007 0.0102
Trypanosoma cruzi polo-like protein kinase, putative 0.0111 0.0255 0.7335
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0048 0.0283
Echinococcus multilocularis microtubule associated protein 2 0.0806 0.2015 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0048 0.0283
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0069 0.1975
Leishmania major cytochrome p450-like protein 0.0021 0.0025 0.0715
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0038 0.0069 0.7764
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0025 0.0025
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0012 0.0061
Echinococcus granulosus solute carrier family 22 0.0038 0.0069 0.0226
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0043 0.0256
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0048 0.0283
Brugia malayi nuclear receptor RXR 0.0014 0.0008 0.0048
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.0025 0.0223
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0025 0.0148
Leishmania major glucose transporter/membrane transporter D2, putative 0.0038 0.0069 0.1975
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0013 0.0007 0.0199
Trypanosoma brucei glucose transporter, putative 0.0038 0.0069 0.1975
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.0838 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0079 0.0173 0.057
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0048 0.0283
Echinococcus multilocularis mitogen activated protein kinase 11 0.0148 0.0348 0.1726
Echinococcus multilocularis abhydrolase domain containing protein 0.0044 0.0085 0.0421
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.0838 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0017 0.0015 0.1183
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.0025 0.0223
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0167 0.0395 0.1182
Schistosoma mansoni sugar transporter 0.0038 0.0069 0.0341
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0048 0.0706
Trypanosoma cruzi sugar transporter, putative 0.0038 0.0069 0.1975
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0098 0.0221 0.0729
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Brugia malayi hypothetical protein 0.0077 0.0168 0.0999
Schistosoma mansoni glucose transport protein 0.0038 0.0069 0.0341
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0167 0.0395 0.3541
Schistosoma mansoni cytochrome P450 0.0021 0.0025 0.0123
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0059
Echinococcus granulosus intermediate filament protein 0.0031 0.0053 0.0173
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0025 0.0715
Trypanosoma cruzi multidrug resistance protein E, putative 0.0017 0.0015 0.0428
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0048 0.0236
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0022 0.0022
Echinococcus granulosus lamin 0.0031 0.0053 0.0173
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0322 0.0788 0.3912
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.0015 0.0178
Schistosoma mansoni lamin 0.0031 0.0053 0.0261
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Onchocerca volvulus 0.0013 0.0007 0.0102
Schistosoma mansoni microtubule-associated protein tau 0.0806 0.2015 1
Brugia malayi calpain 7 0.0022 0.003 0.0176
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0048
Onchocerca volvulus 0.003 0.0048 0.0706
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0013 0.0007 0.0023
Echinococcus granulosus hypothetical protein 0.0816 0.2041 0.6721
Trypanosoma cruzi DNA repair protein, putative 0.0039 0.0071 0.2046
Brugia malayi ecdysteroid receptor 0.003 0.0048 0.0283
Brugia malayi multidrug resistance related protein 1 0.0017 0.0015 0.0089
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0154 0.0507
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0255 0.3045
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0048 0.0283
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0058 0.0191
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0013 0.0007 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0076 0.0911
Loa Loa (eye worm) hypothetical protein 0.0053 0.0107 0.0635
Plasmodium vivax sugar transporter, putative 0.0038 0.0069 0.694
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0048 0.0236
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0082 0.0408
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0038 0.0069 0.0341
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0008 0.004
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.0015 0.0178
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0126 0.362
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0408
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0025 0.0148
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0059
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0025 0.0025
Echinococcus granulosus calpain A 0.0022 0.003 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0048 0.0283
Echinococcus granulosus multidrug resistance associated protein 1 0.0017 0.0015 0.0049
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0048 0.0157
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.0838 1
Schistosoma mansoni Mername-AA248 (C02 family) 0.0022 0.003 0.0147
Loa Loa (eye worm) sugar transporter 0.0038 0.0069 0.0408
Leishmania major glucose transporter, lmgt2 0.0038 0.0069 0.1975
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0087
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0011 0.0037
Loa Loa (eye worm) hypoxia-induced factor 1 0.0176 0.0418 0.2487
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.001 0.0295
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Onchocerca volvulus 0.0013 0.0007 0.0102
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0048 0.0157
Onchocerca volvulus 0.0036 0.0065 0.0963
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.0025 0.0223
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0126 0.0749
Brugia malayi Cytochrome P450 family protein 0.0021 0.0025 0.0148
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0256
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.0838 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0048
Echinococcus multilocularis mitogen activated protein kinase 14 0.0148 0.0348 0.1726
Entamoeba histolytica ABC transporter, putative 0.0017 0.0015 0.0178
Trypanosoma brucei glucose transporter, putative 0.0038 0.0069 0.1975
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0025 0.0715
Trypanosoma brucei glucose transporter 1E 0.0038 0.0069 0.1975
Onchocerca volvulus 0.0013 0.0007 0.0102
Trypanosoma brucei calpain-like protein, putative 0.0022 0.003 0.085
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.001 0.0061
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0283
Brugia malayi beta-NAC-like protein 0.0041 0.0076 0.0454
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0256
Echinococcus multilocularis multidrug resistance associated protein 7 0.0017 0.0015 0.0074
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0451 0.1116 0.3338
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0094
Onchocerca volvulus 0.0014 0.0008 0.012
Trypanosoma brucei glucose transporter, putative 0.0038 0.0069 0.1975
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0038 0.0069 0.0341
Brugia malayi Death domain containing protein 0.0017 0.0015 0.0091
Echinococcus multilocularis solute carrier family 22 0.0038 0.0069 0.0341
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.015
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0013 0.0007 0.0082
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Echinococcus multilocularis jun protein 0.0098 0.0221 0.1099
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0022 0.003 0.085
Loa Loa (eye worm) hypothetical protein 0.0075 0.0163 0.0972
Onchocerca volvulus 4.1 G protein, putative homolog 0.0013 0.0007 0.0102
Leishmania major tyrosine specific protein phosphatase, putative 0.0013 0.0007 0.0199
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0013 0.0007 0.0041
Loa Loa (eye worm) major facilitator superfamily transporter 0.0038 0.0069 0.0408
Schistosoma mansoni hypothetical protein 0.0198 0.0474 0.2354
Brugia malayi Uncoordinated protein 44 0.0017 0.0015 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0048 0.0283
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.053 0.1316 0.6532
Mycobacterium ulcerans hypothetical protein 0.0028 0.0043 0.0385
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0048 0.0157
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0408
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0079 0.0173 0.086
Treponema pallidum replicative DNA helicase (dnaB) 0.0451 0.1116 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0008 0.004
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.053 0.1316 0.6532
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0408
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0076 0.2194
Brugia malayi hydrolase, alpha/beta fold family protein 0.0044 0.0085 0.0505
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0069 0.1975
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.082
Onchocerca volvulus 0.0028 0.0043 0.0638
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0089
Brugia malayi intermediate filament protein 0.0031 0.0053 0.0313
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0022 0.0022
Echinococcus granulosus death domain containing protein 0.0017 0.0015 0.0051
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0013 0.0007 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0061 0.0304
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0013 0.0007 0.0034
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0013 0.0007 0.0023
Onchocerca volvulus 0.0015 0.001 0.0152
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0048
Mycobacterium leprae Conserved hypothetical protein 0.133 0.3344 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.015
Brugia malayi hypothetical protein 0.0038 0.0069 0.0408
Brugia malayi hypothetical protein 0.0191 0.0456 0.271
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0053 0.0313
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0048 0.0236
Loa Loa (eye worm) twinkle helicase 0.0129 0.03 0.1781
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.0025 0.0223
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0408
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0408
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0038 0.0069 0.0069
Echinococcus multilocularis mitogen activated protein kinase 11 0.0148 0.0348 0.1726
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.0025 0.0223
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0013 0.0007 0.0023
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0008 0.012
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0043 0.0385
Onchocerca volvulus 0.0013 0.0007 0.0102
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0025 0.0226
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0008 0.0048
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0017 0.0015 0.0428
Plasmodium vivax hexose transporter 0.0038 0.0069 0.694
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0025 0.0025
Trichomonas vaginalis pten, drome, putative 0.0013 0.0007 0.0082
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0069 0.1975
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0038 0.0069 0.0615
Onchocerca volvulus 0.0013 0.0007 0.0102
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.003 0.085
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0211 0.0507 0.7521
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0341 0.0838 1
Onchocerca volvulus 0.0031 0.0053 0.0781
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0048 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0076 0.0911
Brugia malayi Cytochrome P450 family protein 0.0021 0.0025 0.0148
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0048 0.0236
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0071 0.0154 0.0154
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0079 0.0173 0.086
Giardia lamblia Kinase, PLK 0.0111 0.0255 0.3045
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0008 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0255 0.3045
Leishmania major glucose transporter, lmgt3 0.0038 0.0069 0.1975
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0017 0.0015 0.0428
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0038 0.0069 0.0226
Trypanosoma brucei glucose transporter, putative 0.0038 0.0069 0.1975
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.001 0.0122
Brugia malayi Major Facilitator Superfamily protein 0.0038 0.0069 0.0408
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0017 0.0016 0.0016
Brugia malayi major facilitator superfamily protein 0.0038 0.0069 0.0408
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0048
Brugia malayi Cytochrome P450 family protein 0.0021 0.0025 0.0148
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0013 0.0007 0.0034
Toxoplasma gondii transporter, major facilitator family protein 0.0038 0.0069 0.5456
Schistosoma mansoni protein tyrosine phosphatase 0.0013 0.0007 0.0034
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0008 0.0027
Trypanosoma cruzi hypothetical protein 0.0013 0.0005 0.0148
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0038 0.0069 0.0226
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Schistosoma mansoni calpain-7 (C02 family) 0.0026 0.0038 0.0191
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0039 0.0071 0.2046
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0043 0.0385
Mycobacterium ulcerans putative regulatory protein 0.0042 0.0079 0.0711
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.0025 0.0223
Schistosoma mansoni protein tyrosine phosphatase 0.0013 0.0007 0.0034
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Loa Loa (eye worm) calpain 5 0.0022 0.003 0.0176
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.003 0.085
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0043 0.1237
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0016 0.0093
Trypanosoma brucei calpain-like protein, putative 0.0022 0.003 0.085
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0012 0.0061
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0256
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0012 0.0061
Echinococcus multilocularis synaptic vesicle 2 protein 0.0038 0.0069 0.0344
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0008 0.004
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0025 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0025 0.0025
Giardia lamblia Fructose-bisphosphate aldolase 0.0341 0.0838 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0043 0.0513
Echinococcus multilocularis transcription factor btf3 0.0041 0.0076 0.0379
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0008 0.0048
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0013 0.0007 0.0034
Brugia malayi hypothetical protein 0.0013 0.0007 0.0041
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.001 0.0122
Echinococcus multilocularis conserved hypothetical protein 0.0806 0.2015 1
Brugia malayi ABC transporter transmembrane region family protein 0.0017 0.0015 0.0089
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.003 0.085
Schistosoma mansoni hypothetical protein 0.0038 0.0069 0.0341
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0013 0.0007 0.0034
Onchocerca volvulus 0.0038 0.0069 0.1019
Giardia lamblia ABC transporter, putative 0.0017 0.0015 0.0178
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0082 0.0271
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0048 0.0236
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0071 0.0154 0.4429
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0076
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0283
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0013 0.0007 0.0034
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0008 0.0027
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0013 0.0007 0.0034
Echinococcus granulosus calpain 7 C02 family 0.0022 0.003 0.0097
Loa Loa (eye worm) ICD-1 protein 0.0041 0.0076 0.0454
Schistosoma mansoni glucose transport protein 0.0038 0.0069 0.0341
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0013 0.0007 0.0034
Onchocerca volvulus 0.0038 0.0069 0.1019
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0014 0.04
Leishmania major hypothetical protein, conserved 0.0038 0.0069 0.1975
Brugia malayi MAP kinase sur-1 0.006 0.0126 0.0749
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0013 0.0007 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Brugia malayi conserved hypotetical protein 0.0014 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Schistosoma mansoni zinc finger protein 0.0014 0.0008 0.004
Echinococcus granulosus calpain A 0.0079 0.0173 0.057
Trypanosoma brucei glucose transporter, putative 0.0038 0.0069 0.1975
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0013 0.0007 0.0034
Onchocerca volvulus 0.0013 0.0007 0.0102
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0038 0.0069 0.0341
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0048 0.0236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.0838 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.0025 0.0223
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Brugia malayi Sugar transporter family protein 0.0038 0.0069 0.0408
Echinococcus granulosus geminin 0.0198 0.0474 0.1562
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Leishmania major cytochrome p450-like protein 0.0021 0.0025 0.0715
Brugia malayi calpain 5 0.0022 0.003 0.0176
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.003 0.085
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3632 0.9176 0.9176
Brugia malayi nuclear receptor RXR 0.0016 0.0012 0.0073
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Brugia malayi Major Facilitator Superfamily protein 0.0038 0.0069 0.0408
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0082 0.0408
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0061 0.0304
Brugia malayi Protein kinase domain containing protein 0.0018 0.0019 0.0113
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0048
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0048 0.0236
Chlamydia trachomatis recombinase RecA 0.0126 0.0292 0.2549
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0126 0.1503
Leishmania major glucose transporter, lmgt1 0.0038 0.0069 0.1975
Schistosoma mansoni jun-related protein 0.008 0.0175 0.0868
Trichomonas vaginalis set domain proteins, putative 0.0277 0.0674 0.8043
Echinococcus granulosus solute carrier family 22 0.0038 0.0069 0.0226
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0013 0.0007 0.0023
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0013 0.0007 0.0023
Echinococcus granulosus calpain 5 0.0022 0.003 0.0097
Mycobacterium ulcerans short chain dehydrogenase 0.0017 0.0016 0.014
Brugia malayi calpain family protein 1 0.0075 0.0163 0.0972
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0069 0.082
Schistosoma mansoni coup transcription factor 0.003 0.0048 0.0236
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0082 0.2366
Brugia malayi nuclear hormone receptor 0.0014 0.0008 0.0048
Brugia malayi Pre-SET motif family protein 0.0243 0.0589 0.35
Entamoeba histolytica transcription factor BTF3, putative 0.0041 0.0076 0.0911
Onchocerca volvulus 0.0038 0.0069 0.1019
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.082
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0013 0.0007 0.0199
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.0025 0.0223
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0255 0.3045
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0099 0.7861
Loa Loa (eye worm) protein tyrosine phosphatase 0.0013 0.0007 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0048 0.0283
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0013 0.0007 0.0041
Chlamydia trachomatis replicative DNA helicase 0.0451 0.1116 1
Loa Loa (eye worm) hypothetical protein 0.0674 0.1682 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0111 0.0255 0.3045
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0255 0.3045
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0013 0.0007 0.0023
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0025 0.2856
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0126 0.362
Onchocerca volvulus Putative transporter 0.0038 0.0069 0.1019
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0008 0.0048
Toxoplasma gondii NAC domain-containing protein 0.0041 0.0076 0.6061
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0017 0.0015 0.0428
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0148 0.0348 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.001 0.0122
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.0589 0.35
Echinococcus multilocularis mitogen activated protein kinase 14 0.0148 0.0348 0.1726
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0008 0.004
Plasmodium falciparum epoxide hydrolase 1 0.0044 0.0085 0.9593
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0079 0.0173 0.086
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0099 0.7861
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0283
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Schistosoma mansoni glucose transport protein 0.0038 0.0069 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0082 0.0982
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0013 0.0007 0.0034
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0048 0.0283
Mycobacterium ulcerans integral membrane transport protein 0.0038 0.0069 0.0615
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0082 0.2366
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.082
Echinococcus granulosus lamin dm0 0.0031 0.0053 0.0173
Onchocerca volvulus 0.0053 0.0107 0.1583
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.001 0.0122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0048 0.0236
Plasmodium falciparum hexose transporter 0.0038 0.0069 0.7764
Onchocerca volvulus 0.0038 0.0069 0.1019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0048 0.0157
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0038 0.0069 0.0341
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0025 0.0136
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0053 0.0313
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0053 0.0313
Onchocerca volvulus 0.0038 0.0069 0.1019
Plasmodium vivax calpain, putative 0.0022 0.003 0.2988
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0015 0.0076
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0013 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Trypanosoma brucei glucose transporter, putative 0.0038 0.0069 0.1975
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0013 0.0007 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0013 0.0007 0.0034
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0048
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.001 0.0034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0043 0.0043
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.003 0.085
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0408
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0013 0.0007 0.0023
Brugia malayi hypoxia-induced factor 1 0.0176 0.0418 0.2487
Brugia malayi steroid hormone receptor 0.003 0.0048 0.0283
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0036 0.0065 0.1868
Brugia malayi Sugar transporter family protein 0.0038 0.0069 0.0408
Entamoeba histolytica multidrug resistance protein, putative 0.0017 0.0015 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.082
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0069 0.082
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0408
Loa Loa (eye worm) DR-78 0.0014 0.0008 0.0048
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0255 0.1266
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0048 0.0236
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0008 0.0027
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.0154 0.138
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0013 0.0007 0.0034
Onchocerca volvulus 0.0038 0.0069 0.1019
Loa Loa (eye worm) hypothetical protein 0.0075 0.0163 0.0972
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0279 0.0679 0.404
Entamoeba histolytica calpain large subunit domain III containing protein 0.0022 0.003 0.0353
Brugia malayi bZIP transcription factor family protein 0.0098 0.0221 0.1316
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0015 0.0051
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0126 0.0292 0.2133
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0017 0.0016 0.0047
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0322 0.0788 0.2596
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0169 0.0402 0.1994
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.0154 0.138
Brugia malayi Major Facilitator Superfamily protein 0.0038 0.0069 0.0408
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0025 0.0025
Mycobacterium leprae Possible regulatory protein 0.0015 0.001 0.0031
Loa Loa (eye worm) sugar transporter 0.0038 0.0069 0.0408
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0048 0.0236
Echinococcus multilocularis 0.0013 0.0007 0.0034
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.003 0.085
Schistosoma mansoni kinase 0.0057 0.0118 0.0584
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0048 0.0283
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.0025 0.0223
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0099 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0013 0.0007 0.0023
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0025 0.0715
Treponema pallidum fructose-bisphosphate aldolase 0.0341 0.0838 0.6619
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0015 0.0051
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0013 0.0007 0.0199
Brugia malayi nuclear receptor NHR-88 0.0014 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0048
Brugia malayi hypothetical protein 0.0013 0.0007 0.0041
Onchocerca volvulus 0.0013 0.0007 0.0102
Loa Loa (eye worm) cytochrome P450 family protein 0.0109 0.0249 0.148
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0082 0.0408
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0012 0.0073
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Schistosoma mansoni intermediate filament proteins 0.0031 0.0053 0.0261
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0071 0.0154 0.0916
Leishmania major ABC-thiol transporter 0.0017 0.0015 0.0428
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0008 0.004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0022 0.0022
Brugia malayi Pre-SET motif family protein 0.0035 0.0061 0.0364
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0013 0.0007 0.0034
Echinococcus multilocularis musashi 0.0031 0.0053 0.0261
Onchocerca volvulus 0.0013 0.0007 0.0102
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0025 0.0025
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.0015 0.0178
Onchocerca volvulus 0.0013 0.0007 0.0102
Echinococcus granulosus jun protein 0.0098 0.0221 0.0729
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0025 0.0025
Brugia malayi Sugar transporter family protein 0.0038 0.0069 0.0408
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0008 0.0048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0008 0.0027
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0015 0.0228
Trypanosoma cruzi hexose transporter 0.0038 0.0069 0.1975
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0025 0.0025
Brugia malayi hypothetical protein 0.0016 0.0012 0.0073
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0038 0.0069 0.0341
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0069 0.1975
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0069 0.082
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.0025 0.0223
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.015
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0013 0.0007 0.0023
Echinococcus multilocularis lamin dm0 0.0031 0.0053 0.0261
Plasmodium vivax basic transcription factor 3b, putative 0.0041 0.0076 0.771
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0013 0.0007 0.0023
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Echinococcus granulosus protein tyrosine phosphatase n9 0.0013 0.0007 0.0023
Echinococcus granulosus Sugar transporter ERD6 protein 0.0038 0.0069 0.0226
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0082 0.0489
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0075 0.0163 0.0811
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0408
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0061 0.0201
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.003 0.085
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Leishmania major hypothetical protein, conserved 0.0044 0.0085 0.244
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.0025 0.0223
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.0025 0.0223
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0341 0.0838 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0313
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0015 0.0091
Loa Loa (eye worm) calpain family protein 1 0.0053 0.0107 0.0635
Loa Loa (eye worm) hypothetical protein 0.0053 0.0107 0.0635
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0012 0.0041
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0017 0.0015 0.0428
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0048 0.0157
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0013 0.0007 0.0034
Brugia malayi ecdysone receptor 0.0014 0.0008 0.0048
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Onchocerca volvulus 0.0277 0.0674 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0008 0.0048
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0025 0.0148
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0017 0.0015 0.0428
Trypanosoma cruzi kinesin, putative 0.0022 0.003 0.085
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.082
Schistosoma mansoni sugar transporter 0.0038 0.0069 0.0341
Giardia lamblia Hexose transporter 0.0038 0.0069 0.082
Giardia lamblia Multidrug resistance-associated protein 1 0.0016 0.0015 0.0174
Schistosoma mansoni single-minded 0.0057 0.0117 0.058
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0082 0.0408
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Toxoplasma gondii sugar transporter ST1 0.0038 0.0069 0.5456
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0025 0.0025
Giardia lamblia Protein tyrosine phosphatase 0.0013 0.0007 0.0082
Schistosoma mansoni hypothetical protein 0.008 0.0175 0.0868
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0025 0.2553
Schistosoma mansoni transcription factor btf3 0.0041 0.0076 0.0379
Onchocerca volvulus 0.0013 0.0007 0.0102
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0043 0.0256
Echinococcus granulosus calpain 0.0022 0.003 0.0097
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0126 0.362
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0013 0.0007 0.0082
Onchocerca volvulus 0.0013 0.0007 0.0102
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0025 0.1976
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0048 0.0283
Trypanosoma brucei transcription factor BTF3, putative 0.0041 0.0076 0.2194
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.0015 0.0178
Onchocerca volvulus 0.0013 0.0007 0.0102
Trypanosoma brucei sugar transporter, putative 0.0038 0.0069 0.1975
Echinococcus multilocularis 0.0021 0.0025 0.0123
Brugia malayi hypothetical protein 0.0013 0.0007 0.0041
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0013 0.0007 0.0034
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0451 0.1116 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0048 0.0283
Brugia malayi hypothetical protein 0.0016 0.0012 0.0073
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0025 0.0025
Schistosoma mansoni aryl hydrocarbon receptor 0.0057 0.0117 0.058
Trypanosoma brucei glucose transporter 2A 0.0038 0.0069 0.1975
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0008 0.0048
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0013 0.0007 0.0034
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0013 0.0007 0.0023
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0022 0.003 0.085
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0069 0.1975
Trypanosoma cruzi DNA repair protein, putative 0.0039 0.0071 0.2046
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Echinococcus multilocularis Ankyrin 0.0017 0.0016 0.0078
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0013 0.0007 0.0023
Schistosoma mansoni nuclear receptor 0.0014 0.0008 0.004
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.0025 0.0223
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0043 0.0513
Echinococcus multilocularis lamin 0.0031 0.0053 0.0261
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.003 0.085
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0061 0.0304
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0016 0.0093
Brugia malayi small heat shock protein 0.0674 0.1682 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.0025 0.0223
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0126 0.1503
Mycobacterium ulcerans sugar transporter 0.0038 0.0069 0.0615
Echinococcus multilocularis solute carrier family 22 0.0038 0.0069 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0048 0.0283
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0048
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0126 0.362
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.0025 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0048 0.0283
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0008 0.0027
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0412
Onchocerca volvulus 0.0013 0.0007 0.0102
Leishmania major basic transcription factor 3a, putative 0.0041 0.0076 0.2194
Echinococcus granulosus mitogen activated protein kinase 14 0.0148 0.0348 0.1145
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0025 0.0025
Trypanosoma cruzi glucose transporter, putative 0.0038 0.0069 0.1975
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0017 0.0015 0.0428
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0408
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0013 0.0007 0.0023
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0013 0.0007 0.0034
Schistosoma mansoni glucose transporter 0.0038 0.0069 0.0341
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0022 0.0022
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0283
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0126 0.362
Entamoeba histolytica protein kinase, putative 0.0024 0.0033 0.0396
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Schistosoma mansoni hypothetical protein 0.0198 0.0474 0.2354
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0048 0.0283
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0013 0.0007 0.0023
Loa Loa (eye worm) acetyltransferase 0.0169 0.0402 0.2388
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0126 0.0415
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0408
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0048
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0048 0.0283
Brugia malayi P38 map kinase family protein 2 0.0148 0.0348 0.2068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0048 0.0283
Schistosoma mansoni calpain (C02 family) 0.0022 0.003 0.0147
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0126 0.1503
Echinococcus granulosus solute carrier family 22 0.0038 0.0069 0.0226
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Onchocerca volvulus 0.0013 0.0007 0.0102
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0017 0.0015 0.0428
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.001 0.0051
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.001 0.0122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.0838 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0038 0.0069 0.0226
Schistosoma mansoni thyroid hormone receptor 0.003 0.0048 0.0236
Brugia malayi PAS domain containing protein 0.0057 0.0117 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.001 0.0122
Trypanosoma brucei multidrug resistance protein E 0.0017 0.0015 0.0428
Loa Loa (eye worm) multidrug resistance-associated protein 0.0013 0.0005 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0025 0.0025
Brugia malayi hypothetical protein 0.0013 0.0007 0.0041
Brugia malayi serine/threonine-protein kinase plk-2 0.0111 0.0255 0.1517
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0013 0.0007 0.0034
Schistosoma mansoni calpain C (C02 family) 0.0022 0.003 0.0147
Trypanosoma brucei p-glycoprotein 0.0017 0.0015 0.0428
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0048 0.0236
Leishmania major pentamidine resistance protein 1 0.0017 0.0015 0.0428
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0148 0.0348 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0008 0.0027
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0099 0.1181
Schistosoma mansoni multidrug resistance protein 0.0017 0.0015 0.0074
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0043 0.0129
Loa Loa (eye worm) hypothetical protein 0.0031 0.0051 0.0304
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0016 0.0078
Echinococcus multilocularis multidrug resistance associated protein 4 0.0013 0.0005 0.0025
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0126 0.362
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0098 0.0221 0.1099
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0017 0.0015 0.0428
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.0025 0.0223
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0126 0.0415
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0048 0.0236
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0013 0.0007 0.0034
Echinococcus multilocularis solute carrier family 22 0.0038 0.0069 0.0341
Brugia malayi tailless protein 0.0014 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0043 0.0082 0.0489
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0167 0.0395 0.0395
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0169 0.0402 0.1994
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0015 0.0076
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0038 0.0069 0.1975
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.001 0.0295
Onchocerca volvulus 0.0013 0.0007 0.0102
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0025 0.0715
Schistosoma mansoni multidrug resistance protein 0.0017 0.0015 0.0074
Onchocerca volvulus 0.0077 0.0168 0.2492
Leishmania major p-glycoprotein e 0.0017 0.0015 0.0428
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.0025 0.0223
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.0025 0.0223
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0088 0.1056
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0013 0.0007 0.0082
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0022 0.003 0.085
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.001 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0061 0.0304
Trypanosoma brucei calpain-like protein, putative 0.0022 0.003 0.085
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0013 0.0007 0.0041
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0111 0.0255 0.1517
Onchocerca volvulus 0.0038 0.0069 0.1019
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.003 0.085
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.003 0.085
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Echinococcus granulosus microtubule associated protein 2 0.0806 0.2015 0.6636
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0013 0.0007 0.0034
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0091
Trichomonas vaginalis sugar transport protein, putative 0.0038 0.0069 0.082
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0015 0.0076
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0013 0.0007 0.0041
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0017 0.0015 0.0089
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.0025 0.0223
Onchocerca volvulus 0.0042 0.0079 0.1178
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0082 0.0982
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0013 0.0007 0.0034
Echinococcus granulosus mitogen activated protein kinase 11 0.0148 0.0348 0.1145
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0048 0.0236
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0048
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0061 0.0304
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0283
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0048 0.0283
Onchocerca volvulus 0.0014 0.0008 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0048 0.0283
Echinococcus granulosus multidrug resistance associated protein 7 0.0017 0.0015 0.0049
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.0079 0.0394
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0255 0.3045
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Toxoplasma gondii facilitative glucose transporter GT1 0.0038 0.0069 0.5456
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0048 0.0283
Schistosoma mansoni lamin 0.0031 0.0053 0.0261
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0038 0.0069 0.0621
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0008 0.012
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.053 0.1316 0.4335
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0148 0.0348 0.2068
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.001 0.0051
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0025 0.0082
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0043 0.0256
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0283
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0126 0.0625
Brugia malayi hypothetical protein 0.0014 0.0008 0.0048
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0013 0.0007 0.0023
Echinococcus granulosus histone acetyltransferase KAT2B 0.0164 0.039 0.1283
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.0838 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0041 0.0076 0.8626
Echinococcus granulosus Solute carrier family 22 5 0.1209 0.3036 1
Onchocerca volvulus 0.0038 0.0069 0.1019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0073
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.0025 0.0223
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Onchocerca volvulus 0.0038 0.0069 0.1019
Loa Loa (eye worm) hypothetical protein 0.0191 0.0456 0.271
Schistosoma mansoni protein tyrosine phosphatase 0.0013 0.0007 0.0034
Trypanosoma brucei glucose transporter, putative 0.0038 0.0069 0.1975
Brugia malayi follicle stimulating hormone receptor 0.0279 0.0679 0.404
Onchocerca volvulus 0.0038 0.0069 0.1019
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0255 0.3045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0061 0.0304
Mycobacterium leprae Conserved hypothetical protein 0.0021 0.0025 0.0074
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0008 0.0048
Onchocerca volvulus 0.0038 0.0069 0.1019
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0076 0.0911
Trypanosoma brucei antigen, putative 0.0022 0.003 0.085
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0008 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0048 0.0283
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.003 0.085
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0048 0.0157
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0048 0.0706
Trypanosoma brucei kinesin, putative 0.0022 0.003 0.085
Trypanosoma cruzi polo-like protein kinase, putative 0.0111 0.0255 0.7335
Onchocerca volvulus 0.0031 0.0053 0.0781
Echinococcus granulosus multidrug resistance associated protein 4 0.0013 0.0005 0.0017
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0013 0.0007 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.082
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0126 0.1503
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0013 0.0007 0.0034
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0048 0.0236
Brugia malayi Protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Trypanosoma cruzi kinesin, putative 0.0022 0.003 0.085
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0111 0.0255 0.1266
Brugia malayi cytochrome P450 0.0021 0.0025 0.0148
Loa Loa (eye worm) hypothetical protein 0.0211 0.0507 0.3014
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0008 0.0048
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0014 0.04
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.0015 0.0178
Onchocerca volvulus 0.0038 0.0069 0.1019
Brugia malayi hypothetical protein 0.0013 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0283
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0082 0.0271
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0025 0.0025
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0025 0.0025
Onchocerca volvulus 0.0013 0.0007 0.0102
Echinococcus granulosus nuclear factor of activated T cells 5 0.0086 0.0191 0.0628
Onchocerca volvulus 0.0013 0.0007 0.0102
Trypanosoma brucei glucose transporter, putative 0.0038 0.0069 0.1975
Brugia malayi Protein-tyrosine phosphatase 0.0013 0.0007 0.0041
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0008 0.004
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0043 0.1237
Loa Loa (eye worm) cytochrome P450 0.0021 0.0025 0.0148
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0048 0.0157
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0025 0.0025
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0126 1
Giardia lamblia MRP-like ABC transporter 0.0017 0.0015 0.0178
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0048 0.0236
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0408
Echinococcus granulosus solute carrier family 22 0.0038 0.0069 0.0226
Brugia malayi bHLH-PAS transcription factor 0.0042 0.0079 0.0472
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.015
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.001 0.0295
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0043 0.0385
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0126 0.0625
Onchocerca volvulus 0.0038 0.0069 0.1019
Loa Loa (eye worm) hypothetical protein 0.0095 0.0215 0.1275
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Onchocerca volvulus 0.0035 0.0061 0.0908
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0073
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0025 0.0715
Leishmania major cytochrome p450-like protein 0.0021 0.0025 0.0715
Leishmania major kinesin, putative 0.0022 0.003 0.085
Entamoeba histolytica hypothetical protein 0.0041 0.0076 0.0911
Echinococcus multilocularis calpain family protein 1, d 0.0053 0.0107 0.053
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0076 0.2194
Leishmania major protein kinase, putative 0.0021 0.0025 0.0731
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0041
Echinococcus multilocularis geminin 0.0198 0.0474 0.2354
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0082 0.0271
Brugia malayi hypothetical protein 0.0038 0.0069 0.0408
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0071 0.0154 0.0764
Schistosoma mansoni pcd6 interacting protein-related 0.0013 0.0007 0.0034
Echinococcus multilocularis calpain 0.0022 0.003 0.0147
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0131 0.078
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Schistosoma mansoni sugar transporter 0.0038 0.0069 0.0341
Toxoplasma gondii sugar transporter ST2 0.0038 0.0069 0.5456
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0048 0.0236
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0451 0.1116 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0048
Brugia malayi nuclear hormone receptor 0.003 0.0048 0.0283
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0364
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0082 0.0982
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0082 0.0982
Entamoeba histolytica hypothetical protein 0.0017 0.0015 0.0178
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0013 0.0007 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.015
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0013 0.0007 0.0034
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0013 0.0007 0.0034
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0013 0.0007 0.0023
Brugia malayi hypothetical protein 0.0038 0.0069 0.0408
Schistosoma mansoni multidrug resistance protein 0.0017 0.0015 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0025 0.0025
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0038 0.0069 0.0069
Echinococcus multilocularis hypothetical protein 0.0022 0.003 0.0147
Brugia malayi nuclear receptor NHR-88 0.003 0.0048 0.0283
Echinococcus granulosus single minded 2 0.0042 0.0079 0.0261
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0048 0.0157
Brugia malayi Cytochrome P450 family protein 0.0109 0.0249 0.148
Loa Loa (eye worm) hydrolase 0.0044 0.0085 0.0505
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.001 0.0122
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0008 0.004
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0025 0.0715
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0111 0.0255 0.7335
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0014 0.04
Echinococcus granulosus transcription factor btf3 0.0041 0.0076 0.0251
Loa Loa (eye worm) major facilitator superfamily transporter 0.0038 0.0069 0.0408
Onchocerca volvulus 0.0038 0.0069 0.1019
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0038 0.0069 0.0226
Mycobacterium leprae putative cytochrome p450 0.0021 0.0025 0.0074
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0048 0.0283
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0082 0.0982
Schistosoma mansoni thyroid hormone receptor 0.003 0.0048 0.0236
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0088 0.1056
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0048
Schistosoma mansoni Replicative DNA helicase 0.0451 0.1116 0.5541
Leishmania major myo-inositol/proton symporter (MIT) 0.0038 0.0069 0.1975
Echinococcus granulosus FTZ F1 alpha 0.003 0.0048 0.0157
Trypanosoma brucei protein kinase, putative 0.006 0.0126 0.362
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0148 0.0348 1
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0069 0.082
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0073
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0013 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0408
Schistosoma mansoni nuclear hormone receptor 0.003 0.0048 0.0236
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0048 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0048 0.0283
Onchocerca volvulus 0.0013 0.0007 0.0102
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0013 0.0007 0.0034
Trypanosoma brucei protein tyrosine phosphatase 1 0.0013 0.0007 0.0199
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0011 0.0056
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0061
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.0025 0.0223
Plasmodium vivax SET domain protein, putative 0.0035 0.0061 0.6182
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0043 0.0385
Onchocerca volvulus 0.0013 0.0007 0.0102
Schistosoma mansoni hydrolase 0.0044 0.0085 0.0421
Echinococcus multilocularis calpain 5 0.0022 0.003 0.0147
Schistosoma mansoni nuclear receptor 0.0014 0.0008 0.004

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.6 nM In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane. ChEMBL. 11738578
IC50 (binding) = 1.6 nM In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane. ChEMBL. 11738578

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.