Detailed information for compound 312611

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 484.48 | Formula: C24H26F6N4
  • H donors: 0 H acceptors: 2 LogP: 7.3 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(n1cc2c3c1nc(C)nc3N(CC2)c1ccc(cc1C(F)(F)F)C(F)(F)F)CCC
  • InChi: 1S/C24H26F6N4/c1-4-6-17(7-5-2)34-13-15-10-11-33(21-20(15)22(34)32-14(3)31-21)19-9-8-16(23(25,26)27)12-18(19)24(28,29)30/h8-9,12-13,17H,4-7,10-11H2,1-3H3
  • InChiKey: CSSCMHXZJCPICP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 1 444 aa 445 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0008 0.0007 0.0032
Echinococcus granulosus microsomal glutathione S transferase 3 0.0114 0.0335 0.033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0028 0.0071 0.0066
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0073 0.0208 0.0203
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0077 0.0221 0.0216
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0012 0.0077
Schistosoma mansoni alpha-glucosidase 0.0076 0.0219 0.0219
Echinococcus multilocularis cyclins 0.0032 0.0083 0.0078
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Leishmania major DNA polymerase eta, putative 0.0057 0.0159 0.1627
Echinococcus multilocularis ecdysone induced protein 78C 0.0146 0.0434 0.0429
Schistosoma mansoni hypothetical protein 0.0318 0.0966 0.0966
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0077 0.0752
Loa Loa (eye worm) hypothetical protein 0.0077 0.0221 0.0216
Onchocerca volvulus 0.0146 0.0434 0.0429
Echinococcus granulosus neutral alpha glucosidase AB 0.002 0.0044 0.0039
Brugia malayi Cytochrome P450 family protein 0.0011 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0146 0.0434 0.0429
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0077 0.0221 0.0221
Schistosoma mansoni cyclin d 0.0008 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0077 0.0764
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0028 0.0071 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0007 0.0023
Brugia malayi Cyclin, N-terminal domain containing protein 0.0008 0.0007 0.0002
Onchocerca volvulus Chorion peroxidase homolog 0.3236 1 1
Schistosoma mansoni cyclin B 0.0044 0.0118 0.0118
Entamoeba histolytica cyclin C, putative 0.0008 0.0007 0.0609
Schistosoma mansoni cpg binding protein 0.0047 0.0129 0.0129
Onchocerca volvulus 0.3236 1 1
Echinococcus granulosus snurportin 1 0.0192 0.0579 0.0574
Mycobacterium leprae conserved hypothetical protein 0.0049 0.0134 0.923
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0214 0.0646 0.0641
Entamoeba histolytica cyclin, putative 0.0032 0.0083 0.7037
Onchocerca volvulus 0.0044 0.0118 0.0113
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0146 0.0434 0.0429
Brugia malayi latrophilin 2 splice variant baaae 0.0062 0.0176 0.0171
Echinococcus multilocularis survival motor neuron protein 1 0.0148 0.0441 0.0436
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0016 0.0118
Onchocerca volvulus 0.073 0.2243 0.2239
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0277 0.0839 0.0834
Loa Loa (eye worm) nuclear receptor NHR-67 0.0069 0.0196 0.019
Mycobacterium ulcerans epoxide hydrolase EphA 0.0101 0.0294 0.5921
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0008 0.0007 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0016 0.0228
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0077 0.0752
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0091 0.0266 0.026
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0047 0.0128 0.8736
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0016 0.0122
Trichomonas vaginalis CMGC family protein kinase 0.002 0.0044 0.0426
Mycobacterium ulcerans glyoxalase GloA 0.0049 0.0134 0.2646
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0008 0.0007 0.0022
Brugia malayi Calcitonin receptor-like protein seb-1 0.0091 0.0266 0.0261
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0047 0.0128 0.2517
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.0134 0.2646
Brugia malayi Cadherin domain containing protein 0.073 0.2243 0.2239
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0146 0.0434 0.0429
Schistosoma mansoni Cyclin fold protein 0.0008 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.3236 1 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0016 0.0228
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0146 0.0434 0.0434
Onchocerca volvulus 0.0008 0.0007 0.0002
Schistosoma mansoni polycystin 1-related 0.0012 0.0021 0.0021
Trichomonas vaginalis cyclin B3, putative 0.0008 0.0007 0.0023
Plasmodium vivax protein kinase Crk2 0.002 0.0044 0.3299
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Trichomonas vaginalis cyclin A, putative 0.0044 0.0118 0.1227
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0016 0.0119
Leishmania major mitochondrial DNA polymerase beta 0.0313 0.0952 1
Echinococcus multilocularis neurogenic locus protein delta 0.073 0.2243 0.2239
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0016 0.0011
Schistosoma mansoni cyclin G 0.0008 0.0007 0.0007
Entamoeba histolytica cyclin, domain containing protein 0.0008 0.0007 0.0609
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0007 0.0023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0045 0.0122 0.0116
Schistosoma mansoni survival motor neuron protein 0.003 0.0076 0.0076
Plasmodium falciparum histone acetyltransferase GCN5 0.0021 0.0049 0.3374
Brugia malayi hypothetical protein 0.0069 0.0196 0.0191
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Brugia malayi Muscle positioning protein 4 0.073 0.2243 0.2239
Echinococcus multilocularis muscleblind protein 1 0.0093 0.027 0.0265
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.0014 0.0102
Loa Loa (eye worm) hypothetical protein 0.0069 0.0196 0.019
Echinococcus granulosus cyclin b3 0.0032 0.0083 0.0078
Brugia malayi cyclin fold protein 1 variant b 0.0008 0.0007 0.0002
Trichomonas vaginalis cyclins, putative 0.0008 0.0007 0.0023
Trypanosoma brucei unspecified product 0.003 0.0077 0.0752
Echinococcus multilocularis cyclins 0.0032 0.0083 0.0078
Brugia malayi nuclear hormone receptor family member nhr-6 0.0069 0.0196 0.0191
Echinococcus multilocularis neurogenic locus notch protein 0.073 0.2243 0.2239
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.001 0.0014 0.0102
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0049 0.0134 0.1365
Mycobacterium ulcerans DNA polymerase IV 0.003 0.0077 0.1481
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0016 0.0228
Onchocerca volvulus Protein ultraspiracle homolog 0.0146 0.0434 0.0429
Trichomonas vaginalis cyclin B, putative 0.0044 0.0118 0.1227
Loa Loa (eye worm) hypothetical protein 0.3236 1 1
Brugia malayi Animal haem peroxidase family protein 0.3236 1 1
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Toxoplasma gondii histone lysine methyltransferase SET1 0.0088 0.0256 0.1141
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0091 0.0266 0.0261
Schistosoma mansoni hypothetical protein 0.073 0.2243 0.2243
Trichomonas vaginalis cyclins, putative 0.0019 0.0042 0.0403
Leishmania major mitotic cyclin, putative 0.0008 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0077 0.0221 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0014 0.0102
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0016 0.0011
Trypanosoma cruzi importin beta-1 subunit, putative 0.0015 0.0028 0.0245
Trypanosoma brucei chrX additional, unordered contigs 0.0009 0.0012 0.0076
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0016 0.0228
Schistosoma mansoni cyclin l 0.0008 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.3236 1 1
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.003 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0077 0.0752
Plasmodium vivax SET domain protein, putative 0.0039 0.0105 0.7788
Onchocerca volvulus 0.0039 0.0105 0.0099
Trypanosoma cruzi cdc2-related kinase 3 0.002 0.0044 0.0415
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0069 0.0196 0.0191
Brugia malayi Protein kinase domain containing protein 0.002 0.0044 0.0039
Onchocerca volvulus Peroxidasin homolog 0.3236 1 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0016 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0016 0.0228
Echinococcus granulosus mixed lineage leukemia protein mll 0.0013 0.0022 0.0017
Brugia malayi EGF-like domain containing protein 0.073 0.2243 0.2239
Plasmodium falciparum cyclin 0.0032 0.0083 0.6042
Echinococcus granulosus cyclin dependent kinase 0.002 0.0044 0.0039
Trichomonas vaginalis alpha-glucosidase, putative 0.0007 0.0006 0.0006
Echinococcus granulosus survival motor neuron protein 1 0.0148 0.0441 0.0436
Schistosoma mansoni alpha-glucosidase 0.0076 0.0219 0.0219
Schistosoma mansoni ap endonuclease 0.0023 0.0054 0.0054
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0016 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.0014 0.0102
Giardia lamblia Kinase, CMGC CDK 0.002 0.0044 0.0175
Echinococcus granulosus Cyclin L1 0.0008 0.0007 0.0002
Leishmania major glycosyl hydrolase-like protein 0.0007 0.0006 0.0006
Giardia lamblia G2/mitotic-specific cyclin B 0.0044 0.0118 0.0505
Toxoplasma gondii glyoxalase family protein 0.0049 0.0134 0.0599
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.0448
Giardia lamblia Hypothetical protein 0.0008 0.0007 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.0071 0.0071
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0054 1
Schistosoma mansoni rab6-interacting 0.0012 0.0021 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0016 0.0228
Loa Loa (eye worm) hypothetical protein 0.0069 0.0196 0.019
Leishmania major cytochrome p450-like protein 0.0011 0.0016 0.0118
Plasmodium falciparum protein kinase 5 0.002 0.0044 0.3038
Trichomonas vaginalis cyclin B, putative 0.0008 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0077 0.022 0.0215
Echinococcus multilocularis neurogenic locus protein delta 0.073 0.2243 0.2239
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.002 0.0044 0.0039
Schistosoma mansoni loxhd1 0.0012 0.0021 0.0021
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0016 0.0117
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0054 0.053
Trichomonas vaginalis cyclin D, putative 0.0032 0.0083 0.0847
Loa Loa (eye worm) animal heme peroxidase 0.3236 1 1
Schistosoma mansoni hypothetical protein 0.0012 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0057 0.0159 0.0154
Brugia malayi Cyclin, N-terminal domain containing protein 0.0032 0.0083 0.0078
Onchocerca volvulus Bile acid receptor homolog 0.0146 0.0434 0.0429
Plasmodium vivax glyoxalase I, putative 0.0049 0.0134 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0196 0.019
Leishmania major DNA polymerase kappa, putative 0.0009 0.0012 0.0077
Echinococcus multilocularis protein jagged 2 0.073 0.2243 0.2239
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.0014 0.0102
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0054 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0091 0.0266 0.0266
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.003 0.0076 0.0071
Echinococcus granulosus neurogenic locus notch protein 4 0.073 0.2243 0.2239
Schistosoma mansoni RAR-like nuclear receptor 0.0146 0.0434 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0146 0.0434 0.0429
Echinococcus granulosus histone acetyltransferase KAT2B 0.0023 0.0055 0.005
Schistosoma mansoni peroxidasin 0.3236 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0028 0.0071 0.0066
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.0494 1
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Giardia lamblia High cysteine protein 0.073 0.2243 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0054 0.0516
Schistosoma mansoni alpha glucosidase 0.002 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.073 0.2243 0.2243
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0434 0.0434
Schistosoma mansoni hypothetical protein 0.073 0.2243 0.2243
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.002 0.0044 0.3704
Echinococcus granulosus cyclin 0.0008 0.0007 0.0002
Toxoplasma gondii cyclin dependent kinase binding protein 0.0008 0.0007 0.0032
Echinococcus granulosus protein jagged 2 0.073 0.2243 0.2239
Plasmodium vivax DNA repair protein REV1, putative 0.0009 0.0012 0.0917
Schistosoma mansoni nuclear hormone receptor 0.0069 0.0196 0.0196
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0044 0.042
Loa Loa (eye worm) Notch2 0.073 0.2243 0.2239
Schistosoma mansoni steroid hormone receptor ad4bp 0.0146 0.0434 0.0434
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0032 0.0083 0.0078
Onchocerca volvulus Peroxidase homolog 0.3236 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0214 0.0646 0.0641
Echinococcus multilocularis dnaJ subfamily B 0.0303 0.092 0.0916
Brugia malayi Animal haem peroxidase family protein 0.3236 1 1
Echinococcus multilocularis inositol monophosphatase 1 0.0023 0.0053 0.0048
Entamoeba histolytica acetyltransferase, GNAT family 0.0021 0.0049 0.4119
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0039 0.0105 0.0466
Echinococcus granulosus microtubule associated protein 2 0.0885 0.2724 0.272
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0016 0.0228
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0077 0.0752
Entamoeba histolytica cell division protein kinase 2, putative 0.002 0.0044 0.375
Echinococcus multilocularis fat cadherin tumor suppressor 0.073 0.2243 0.2239
Toxoplasma gondii EGF family domain-containing protein 0.073 0.2243 1
Echinococcus multilocularis cyclins 0.0032 0.0083 0.0078
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0094 0.094
Brugia malayi cytochrome P450 0.0011 0.0016 0.0011
Brugia malayi orphan nuclear receptor NR2E1 0.0069 0.0196 0.0191
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0022 0.0017
Echinococcus multilocularis neurogenic locus notch protein 0.073 0.2243 0.2239
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.002 0.0044 0.0198
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0192 0.0579 0.0573
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0192 0.0187
Schistosoma mansoni cyclin B3 0.0032 0.0083 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.0448
Brugia malayi Cyclin, N-terminal domain containing protein 0.0008 0.0007 0.0002
Loa Loa (eye worm) RecQ helicase 0.0011 0.0016 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0105 0.0105
Trichomonas vaginalis inositol monophosphatase, putative 0.0023 0.0053 0.0524
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.0952 1
Schistosoma mansoni importin beta-1 0.0018 0.0039 0.0039
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0023 0.0053 0.0524
Echinococcus multilocularis cyclin y 0.0008 0.0007 0.0002
Echinococcus multilocularis cyclin B 0.0044 0.0118 0.0113
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0077 0.022 0.0215
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0039 0.0105 0.01
Leishmania major cytochrome p450-like protein 0.0011 0.0016 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0014 0.0102
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.002 0.0044 0.0038
Brugia malayi lactoylglutathione lyase 0.0049 0.0134 0.0129
Leishmania major DNA polymerase kappa, putative 0.003 0.0077 0.0764
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0119 0.1189
Echinococcus granulosus lipoxygenase domain containing protein 0.0012 0.0021 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0105 0.0105
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.002 0.0044 0.042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0146 0.0434 0.0429
Loa Loa (eye worm) hypothetical protein 0.0069 0.0196 0.019
Mycobacterium tuberculosis Probable dehydrogenase 0.0047 0.0128 0.2517
Echinococcus granulosus cyclin y 0.0008 0.0007 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0077 0.0752
Loa Loa (eye worm) hypothetical protein 0.0069 0.0196 0.019
Echinococcus granulosus cyclins 0.0032 0.0083 0.0078
Loa Loa (eye worm) steroid hormone receptor 0.0146 0.0434 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0014 0.0102
Brugia malayi Blistered cuticle protein 3 0.3236 1 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0023 0.0053 0.4516
Loa Loa (eye worm) hypothetical protein 0.0148 0.0441 0.0435
Brugia malayi acetyltransferase, GNAT family protein 0.0079 0.0227 0.0222
Onchocerca volvulus Slit protein homolog 0.073 0.2243 0.2239
Trypanosoma cruzi cyclin, putative 0.0044 0.0118 0.1194
Mycobacterium ulcerans glyoxalase GloA 0.0049 0.0134 0.2646
Echinococcus granulosus nuclear receptor nhr 48 0.0069 0.0196 0.0191
Echinococcus granulosus cyclin A3 4 0.0008 0.0007 0.0002
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0016 0.0228
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0016 0.1381
Schistosoma mansoni tar DNA-binding protein 0.0091 0.0266 0.0266
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0022 0.0017
Schistosoma mansoni nuclear receptor 0.0069 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.3236 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0073 0.0067
Schistosoma mansoni lipoxygenase 0.0051 0.014 0.014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0028 0.0252
Brugia malayi Glycosyl hydrolases family 31 protein 0.0088 0.0257 0.0252
Onchocerca volvulus Cyclin L homolog 0.0008 0.0007 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0014 0.0102
Echinococcus granulosus cyclin B3 1 0.0032 0.0083 0.0078
Echinococcus granulosus FTZ F1 alpha 0.0146 0.0434 0.0429
Loa Loa (eye worm) acetyltransferase 0.0079 0.0227 0.0221
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0146 0.0434 0.0429
Mycobacterium ulcerans biphenyl-2,3-diol 1,2-dioxygenase 0.0049 0.0134 0.2646
Trypanosoma brucei trypanothione reductase 0.0021 0.0047 0.0432
Brugia malayi hypothetical protein 0.0008 0.0007 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0077 0.0752
Loa Loa (eye worm) animal heme peroxidase 0.3236 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0022 0.0022
Plasmodium vivax importin-beta 2, putative 0.0018 0.0039 0.2891
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0016 0.0228
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0101 0.0294 0.5921
Onchocerca volvulus 0.0136 0.0403 0.0398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0146 0.0434 0.0429
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0054 0.0516
Brugia malayi Glycosyl hydrolases family 31 protein 0.0007 0.0006 0.0001
Loa Loa (eye worm) cyclin C 0.0008 0.0007 0.0002
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0016 0.0011
Schistosoma mansoni cyclin G2 0.0008 0.0007 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0077 0.0752
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.0221 0.0216
Echinococcus granulosus lipoxygenase domain containing protein 0.0012 0.0021 0.0016
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0146 0.0434 0.0429
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0053 0.051
Loa Loa (eye worm) blistered cuticle protein 3 0.3236 1 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0032 0.0083 0.0078
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0016 0.0228
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0016 0.0228
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0442 0.461
Brugia malayi Cyclin, N-terminal domain containing protein 0.0115 0.034 0.0335
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0146 0.0434 0.0429
Echinococcus multilocularis cyclin dependent kinase 5 0.002 0.0044 0.0039
Loa Loa (eye worm) hypothetical protein 0.0044 0.0118 0.0113
Brugia malayi Cyclin, N-terminal domain containing protein 0.0008 0.0007 0.0002
Onchocerca volvulus Cyclin L homolog 0.0008 0.0007 0.0002
Entamoeba histolytica hypothetical protein 0.0015 0.0028 0.2393
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0016 0.0228
Toxoplasma gondii hypothetical protein 0.0025 0.0059 0.0263
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0054 0.0218
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0146 0.0434 0.0429
Trypanosoma cruzi DNA damage repair protein, putative 0.0009 0.0012 0.0077
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0047 0.0128 0.2517
Brugia malayi GCC2 and GCC3 family protein 0.073 0.2243 0.2239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0146 0.0434 0.0429
Brugia malayi polk-prov protein 0.0009 0.0012 0.0007
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0146 0.0434 0.0434
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0007 0.0023
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.002 0.0046 0.2328
Echinococcus multilocularis cyclin G2 0.0008 0.0007 0.0002
Trichomonas vaginalis helicase, putative 0.001 0.0014 0.0102
Trypanosoma cruzi cyclin, putative 0.0044 0.0118 0.1194
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Schistosoma mansoni rab6-interacting 0.0012 0.0021 0.0021
Brugia malayi hypothetical protein 0.0077 0.0221 0.0216
Entamoeba histolytica hypothetical protein 0.0008 0.0007 0.0609
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0077 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.0071 0.0071
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0077 0.0221 0.0216
Schistosoma mansoni hypothetical protein 0.003 0.0076 0.0076
Trichomonas vaginalis maltase-glucoamylase, putative 0.002 0.0044 0.042
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0054 0.3782
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.002 0.0046 0.0838
Brugia malayi Muscleblind-like protein 0.0093 0.027 0.0265
Trypanosoma brucei cytochrome P450, putative 0.0011 0.0016 0.0116
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0016 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0014 0.0102
Trypanosoma brucei glycosyl hydrolase-like protein 0.0007 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0277 0.0839 0.0834
Loa Loa (eye worm) hypothetical protein 0.3236 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.0002
Echinococcus granulosus bloom syndrome protein 0.0011 0.0016 0.0011
Echinococcus granulosus neural cadherin 0.073 0.2243 0.2239
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.002 0.0044 0.0039
Schistosoma mansoni hypothetical protein 0.0029 0.0073 0.0073
Onchocerca volvulus Peroxidase homolog 0.3236 1 1
Schistosoma mansoni peroxidasin 0.3236 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0118 0.0113
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0094 0.0419
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0023 0.0053 0.9882
Echinococcus multilocularis slit 2 protein 0.073 0.2243 0.2239
Onchocerca volvulus Dual oxidase homolog 0.3236 1 1
Schistosoma mansoni hypothetical protein 0.073 0.2243 0.2243
Brugia malayi CXXC zinc finger family protein 0.0045 0.0122 0.0117
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.002 0.0044 0.0039
Schistosoma mansoni DNA helicase recq1 0.0011 0.0016 0.0016
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0008 0.0007 0.0002
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0054 0.4565
Echinococcus multilocularis GPCR, family 2 0.0029 0.0073 0.0067
Brugia malayi Cytochrome P450 family protein 0.0011 0.0016 0.0011
Brugia malayi notch-like transmembrane receptor 0.073 0.2243 0.2239
Echinococcus multilocularis cpg binding protein 0.0047 0.0129 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0146 0.0434 0.0429
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0146 0.0434 0.0429
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0016 0.0228
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.002 0.0044 0.0039
Echinococcus granulosus GPCR family 2 0.0029 0.0073 0.0067
Trypanosoma brucei importin beta-1 subunit, putative 0.0018 0.0039 0.0351
Trypanosoma brucei DNA damage repair protein, putative 0.0009 0.0012 0.0076
Trichomonas vaginalis cyclins, putative 0.0032 0.0083 0.0847
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0044 0.042
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0016 0.0228
Echinococcus granulosus cyclin G2 0.0008 0.0007 0.0002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0028 0.0252
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0044 0.0409
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0016 0.0228
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0069 0.0196 0.0191
Onchocerca volvulus 0.073 0.2243 0.2239
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0023 0.0055 0.0244
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0007 0.0006 0.0478
Loa Loa (eye worm) hypothetical protein 0.3236 1 1
Schistosoma mansoni zinc finger protein 0.0069 0.0196 0.0196
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0016 0.0228
Brugia malayi Calcium binding EGF domain containing protein 0.073 0.2243 0.2239
Schistosoma mansoni hypothetical protein 0.0192 0.0579 0.0579
Trichomonas vaginalis bromodomain-containing protein, putative 0.0023 0.0055 0.0538
Loa Loa (eye worm) hypothetical protein 0.0069 0.0196 0.019
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0496 0.1517 0.1517
Mycobacterium ulcerans hypothetical protein 0.0165 0.0494 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0016 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0014 0.0102
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.003 0.0077 0.0077
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0016 0.0011
Giardia lamblia DINP protein human, muc B family 0.003 0.0077 0.0323
Brugia malayi Inositol-1 0.0023 0.0053 0.0048
Plasmodium falciparum cyclin 1 0.0008 0.0007 0.0166
Giardia lamblia Cyclin A 0.0032 0.0083 0.0349
Trichomonas vaginalis set domain proteins, putative 0.0305 0.0927 1
Mycobacterium tuberculosis Cadmium inducible protein CadI 0.0049 0.0134 0.2646
Loa Loa (eye worm) hypothetical protein 0.3236 1 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0023 0.0055 0.0538
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0016 0.0228
Trichomonas vaginalis cyclin B, putative 0.0008 0.0007 0.0023
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0016 0.0228
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0146 0.0434 0.0434
Echinococcus multilocularis cyclin y 0.0008 0.0007 0.0002
Echinococcus granulosus dna polymerase eta 0.0057 0.0159 0.0154
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.073 0.2243 0.2239
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0016 0.0228
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0016 0.0072
Mycobacterium ulcerans hypothetical protein 0.0049 0.0134 0.2646
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.002 0.0044 0.0415
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0007 0.0005 0.5
Schistosoma mansoni lipoxygenase 0.0073 0.0208 0.0208
Brugia malayi Cytochrome P450 family protein 0.002 0.0045 0.004
Entamoeba histolytica cyclin family protein 0.0032 0.0083 0.7037
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0016 0.0228
Trypanosoma cruzi CYC2-like cyclin, putative 0.0044 0.0118 0.1194
Brugia malayi Nuclear hormone receptor E75 0.0069 0.0196 0.0191
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.073 0.2243 0.2243
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0008 0.0007 0.0166
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0192 0.3817
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0134 0.1402
Schistosoma mansoni nuclear hormone receptor 0.0146 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.3236 1 1
Onchocerca volvulus 0.0305 0.0927 0.0922
Onchocerca volvulus 0.3236 1 1
Schistosoma mansoni tar DNA-binding protein 0.0091 0.0266 0.0266
Loa Loa (eye worm) 4-hydroxyphenylpyruvate dioxygenase 0.0333 0.1014 0.1009
Trichomonas vaginalis alpha-glucosidase, putative 0.0007 0.0006 0.0006
Echinococcus granulosus muscleblind protein 0.0093 0.027 0.0265
Echinococcus granulosus neurogenic locus notch protein 0.073 0.2243 0.2239
Brugia malayi RNA, U transporter 1 0.0051 0.0142 0.0137
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.001 0.0014 0.0102
Echinococcus granulosus cyclins 0.0032 0.0083 0.0078
Brugia malayi Glycosyl hydrolases family 31 protein 0.002 0.0044 0.0039
Onchocerca volvulus Neurogenic locus notch protein homolog 0.073 0.2243 0.2239
Schistosoma mansoni hypothetical protein 0.0029 0.0073 0.0073
Echinococcus multilocularis G1:S specific cyclin D1 0.0008 0.0007 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0007 0.0006 0.0006
Echinococcus multilocularis microtubule associated protein 2 0.0885 0.2724 0.272
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0044 0.0044
Brugia malayi hypothetical protein 0.0008 0.0007 0.0002
Loa Loa (eye worm) cytochrome P450 0.0011 0.0016 0.0011
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0052 0.0144 0.2848
Trichomonas vaginalis maltase-glucoamylase, putative 0.0007 0.0006 0.0006
Onchocerca volvulus Protein CNPPD1 homolog 0.0008 0.0007 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0007 0.0535
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0146 0.0434 0.0429
Toxoplasma gondii hypothetical protein 0.0051 0.0139 0.0621
Trichomonas vaginalis CMGC family protein kinase 0.002 0.0044 0.0426
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0069 0.0196 0.0191
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.0952 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0096 0.0281 0.0281
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0119 0.1206
Loa Loa (eye worm) nuclear hormone receptor 0.0069 0.0196 0.019
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0052 0.0144 0.2848
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0008 0.0007 0.0535
Trypanosoma brucei DNA polymerase eta, putative 0.0057 0.0159 0.1603
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0083 0.0847
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0023 0.0053 0.0989
Onchocerca volvulus 0.0045 0.0122 0.0116
Trichomonas vaginalis cyclin B3, putative 0.0032 0.0083 0.0847
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0146 0.0434 0.0429
Trichomonas vaginalis cyclin B, putative 0.0032 0.0083 0.0847
Loa Loa (eye worm) hypothetical protein 0.0146 0.0434 0.0429
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0016 0.0118
Loa Loa (eye worm) TAR-binding protein 0.0091 0.0266 0.0261
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.0014 0.0102
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0016 0.0228
Brugia malayi Cadherin domain containing protein 0.073 0.2243 0.2239
Echinococcus multilocularis cyclins 0.0032 0.0083 0.0078
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0069 0.0196 0.019
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0069 0.0196 0.0191
Brugia malayi hypothetical protein 0.0077 0.022 0.0215
Brugia malayi RNA binding protein 0.0091 0.0266 0.0261
Loa Loa (eye worm) hypothetical protein 0.3236 1 1
Schistosoma mansoni microtubule-associated protein tau 0.0885 0.2724 0.2724
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0146 0.0434 0.0429
Plasmodium vivax cyclin 4, putative 0.0008 0.0007 0.0535
Brugia malayi nuclear hormone receptor 0.0069 0.0196 0.0191
Brugia malayi Cyclin, N-terminal domain containing protein 0.0044 0.0118 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0016 0.0228
Brugia malayi Importin beta-1 subunit 0.0018 0.0039 0.0034
Plasmodium falciparum glutathione reductase 0.0021 0.0047 0.3213
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0016 0.0228
Giardia lamblia Cyclin B-like protein 0.0008 0.0007 0.001
Brugia malayi EGF-like domain containing protein 0.073 0.2243 0.2239
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1027 0.3163 0.3159
Echinococcus multilocularis dna polymerase kappa 0.003 0.0077 0.0072
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0008 0.0007 0.0032
Trichomonas vaginalis importin beta-1, putative 0.0015 0.0028 0.0252
Giardia lamblia Hypothetical protein 0.0008 0.0007 0.001
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0079 0.0227 0.0222
Schistosoma mansoni cpg binding protein 0.0045 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0146 0.0434 0.0429
Leishmania major cyclin 0.0044 0.0118 0.1194
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0146 0.0434 0.0429
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0016 0.0228
Brugia malayi ecdysteroid receptor 0.0146 0.0434 0.0429
Loa Loa (eye worm) glutathione reductase 0.0021 0.0047 0.0041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0015
Echinococcus granulosus G1:S specific cyclin D1 0.0008 0.0007 0.0002
Echinococcus granulosus cyclins 0.0008 0.0007 0.0002
Leishmania major importin beta-1 subunit, putative 0.0015 0.0028 0.0245
Onchocerca volvulus Putative cubilin 0.073 0.2243 0.2239
Trypanosoma cruzi cdc2-related kinase 1 0.002 0.0044 0.0415
Trypanosoma cruzi cyclin 6, putative 0.0044 0.0118 0.1194
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0159 0.0154
Echinococcus multilocularis cyclin k 0.0008 0.0007 0.0002
Trypanosoma brucei unspecified product 0.0021 0.0048 0.0448
Loa Loa (eye worm) hypothetical protein 0.3236 1 1
Schistosoma mansoni hypothetical protein 0.073 0.2243 0.2243
Trichomonas vaginalis cyclin B, putative 0.0044 0.0118 0.1227
Echinococcus multilocularis cyclins 0.0032 0.0083 0.0078
Toxoplasma gondii MAPEG family protein 0.0114 0.0335 0.1492
Plasmodium falciparum glyoxalase I 0.0049 0.0134 1
Plasmodium falciparum importin beta, putative 0.0018 0.0039 0.2613
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0016 0.0228
Schistosoma mansoni retinoic acid receptor RXR 0.0146 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Brugia malayi Cytochrome P450 family protein 0.0011 0.0016 0.0011
Schistosoma mansoni cell polarity protein 0.073 0.2243 0.2243
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.003 0.0025
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0016 0.0073
Echinococcus granulosus Nuclear hormone receptor HR96 0.0069 0.0196 0.0191
Echinococcus granulosus cyclins 0.0032 0.0083 0.0078
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0007 0.0006 0.0006
Giardia lamblia Kinase, CMGC CDK 0.002 0.0044 0.0175
Schistosoma mansoni DNA polymerase IV / kappa 0.0009 0.0012 0.0012
Brugia malayi nuclear receptor RXR 0.0077 0.0221 0.0216
Schistosoma mansoni cpg binding protein 0.0047 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0077 0.0221 0.0216
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0119 0.1206
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0016 0.0228
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0077 0.0752
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0016 0.0228
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0016 0.0122
Onchocerca volvulus 0.073 0.2243 0.2239
Loa Loa (eye worm) hypothetical protein 0.0146 0.0434 0.0429
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0077 0.0752
Brugia malayi Calcium binding EGF domain containing protein 0.073 0.2243 0.2239
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0016 0.0228
Echinococcus multilocularis Cyclin L1 0.0008 0.0007 0.0002
Brugia malayi Animal haem peroxidase family protein 0.3236 1 1
Toxoplasma gondii exonuclease III APE 0.0023 0.0054 0.024
Brugia malayi cell division control protein 2 homolog 0.002 0.0044 0.0039
Brugia malayi Cyclin, N-terminal domain containing protein 0.0008 0.0007 0.0002
Onchocerca volvulus Huntingtin homolog 0.0077 0.022 0.0215
Loa Loa (eye worm) hypothetical protein 0.3236 1 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0221 0.0216
Brugia malayi hypothetical protein 0.0069 0.0196 0.0191
Echinococcus multilocularis dna polymerase eta 0.0057 0.0159 0.0154
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0073 0.0208 0.0203
Loa Loa (eye worm) hypothetical protein 0.0069 0.0196 0.019
Schistosoma mansoni cytochrome P450 0.0011 0.0016 0.0016
Echinococcus granulosus delta-like protein 1 0.073 0.2243 0.2239
Brugia malayi EGF-like domain containing protein 0.073 0.2243 0.2239
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0192 0.3817
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0016 0.0228
Schistosoma mansoni hypothetical protein 0.0029 0.0073 0.0073
Giardia lamblia DNA damage repair protein 0.0009 0.0012 0.0032
Brugia malayi nuclear receptor NHR-88 0.0069 0.0196 0.0191
Loa Loa (eye worm) hypothetical protein 0.0146 0.0434 0.0429
Brugia malayi Cyclin, N-terminal domain containing protein 0.0044 0.0118 0.0113
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.003 0.0077 0.0072
Onchocerca volvulus 0.0012 0.0021 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0007 0.0023
Schistosoma mansoni g1/s-specific cyclin C 0.0008 0.0007 0.0007
Echinococcus granulosus cyclins 0.0032 0.0083 0.0078
Loa Loa (eye worm) hypothetical protein 0.3236 1 1
Schistosoma mansoni tar DNA-binding protein 0.0091 0.0266 0.0266
Echinococcus multilocularis muscleblind protein 0.0093 0.027 0.0265
Echinococcus granulosus protein jagged 1 0.073 0.2243 0.2239
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0192 0.0187
Onchocerca volvulus Huntingtin homolog 0.0077 0.022 0.0215
Trypanosoma cruzi cdc2-related kinase 3 0.002 0.0044 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0077 0.0752
Toxoplasma gondii HEAT repeat-containing protein 0.0018 0.0039 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0014 0.0102
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0007 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0146 0.0434 0.0429
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0009 0.0012 0.0055
Schistosoma mansoni cyclin k 0.0008 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0077 0.0752
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0069 0.0196 0.0196
Giardia lamblia Cyclin fold protein 1, putative 0.0008 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.0002
Schistosoma mansoni cyclins 0.0032 0.0083 0.0083
Loa Loa (eye worm) animal heme peroxidase 0.3236 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0093 0.027 0.0265
Brugia malayi hypothetical protein 0.0136 0.0403 0.0399
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0016 0.0118
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0053 0.051
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.002 0.0044 0.3704
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0114 0.0335 0.033
Echinococcus granulosus cyclin G2 0.0008 0.0007 0.0002
Leishmania major DNA damage repair protein, putative 0.0009 0.0012 0.0077
Mycobacterium ulcerans hypothetical protein 0.0009 0.0012 0.0149
Echinococcus multilocularis RUN 0.0012 0.0021 0.0016
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0016 0.0073
Trichomonas vaginalis alpha-glucosidase, putative 0.0007 0.0006 0.0006
Trypanosoma brucei RNA helicase, putative 0.0318 0.0966 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.0434 0.0429
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0047 0.0128 0.2517
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Echinococcus granulosus lysosomal alpha glucosidase 0.0088 0.0257 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0146 0.0434 0.0429
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0054 0.053
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0044 0.042
Trichomonas vaginalis DNA helicase recq1, putative 0.0011 0.0016 0.0122
Toxoplasma gondii thioredoxin reductase 0.0021 0.0047 0.0208
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.002 0.0044 0.0415
Schistosoma mansoni notch 0.073 0.2243 0.2243
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0088 0.0257 0.0251
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0077 0.0221 0.0216
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0146 0.0434 0.0429
Schistosoma mansoni septate junction protein 0.073 0.2243 0.2243
Echinococcus granulosus notch 0.073 0.2243 0.2239
Echinococcus granulosus histone acetyltransferase KAT2B 0.0076 0.022 0.0215
Trypanosoma cruzi DNA damage repair protein, putative 0.0009 0.0012 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0105 0.0105
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0008 0.0007 0.0002
Echinococcus granulosus geminin 0.0206 0.0622 0.0617
Loa Loa (eye worm) hypothetical protein 0.3236 1 1
Plasmodium vivax cyclin homologue, putative 0.0008 0.0007 0.0535
Giardia lamblia Hypothetical protein 0.0032 0.0083 0.0349
Echinococcus granulosus histone lysine methyltransferase setb 0.0039 0.0105 0.01
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Brugia malayi Delta serrate ligand family protein 0.073 0.2243 0.2239
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0044 0.0044
Brugia malayi EGF-like domain containing protein 0.073 0.2243 0.2239
Echinococcus granulosus cyclin y 0.0008 0.0007 0.0002
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0016 0.0011
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0023 0.0055 0.4068
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0016 0.0228
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0016 0.0228
Schistosoma mansoni nuclear receptor nhr-48 0.0069 0.0196 0.0196
Toxoplasma gondii NADPH-glutathione reductase 0.0007 0.0005 0.0023
Plasmodium vivax glutathione reductase, putative 0.0021 0.0047 0.3468
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0146 0.0434 0.0429
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0192 0.0192
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.0014 0.0102
Echinococcus granulosus RUN 0.0012 0.0021 0.0016
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0054 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0023 0.0055 0.0244
Brugia malayi nuclear hormone receptor 0.0146 0.0434 0.0429
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0015
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.0442 0.4542
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0149 0.1521
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.003 0.0077 0.0072
Brugia malayi Steroid receptor seven-up type 2 0.0146 0.0434 0.0429
Echinococcus multilocularis thioredoxin glutathione reductase 0.0021 0.0047 0.0042
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0192 0.0854
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.003 0.0077 0.0764
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.0014 0.0102
Brugia malayi Pre-SET motif family protein 0.0039 0.0105 0.01
Trichomonas vaginalis cyclins, putative 0.0044 0.0118 0.1227
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.002 0.0044 0.042
Mycobacterium tuberculosis Probable reductase 0.0047 0.0128 0.2517
Schistosoma mansoni notch 0.073 0.2243 0.2243
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0077 0.0764
Mycobacterium ulcerans DNA polymerase IV 0.003 0.0077 0.1481
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0008 0.0007 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0192 0.3817
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.003 0.0025
Schistosoma mansoni gynecophoral canal protein 0.0049 0.0134 0.0134
Trypanosoma cruzi mitotic cyclin, putative 0.0008 0.0007 0.0023
Brugia malayi Latrophilin receptor protein 2 0.0029 0.0073 0.0067
Brugia malayi Cyclin C 0.0008 0.0007 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0146 0.0434 0.0429
Brugia malayi Cyclin, N-terminal domain containing protein 0.0008 0.0007 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0007 0.0006 0.0006
Onchocerca volvulus 0.0012 0.0021 0.0015
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0007 0.0005 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0014 0.0102
Trypanosoma brucei importin beta-1 subunit, putative 0.0018 0.0039 0.0351
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.003 0.0077 0.0072
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Echinococcus multilocularis neutral alpha glucosidase AB 0.002 0.0044 0.0039
Trichomonas vaginalis cyclin B, putative 0.0044 0.0118 0.1227
Schistosoma mansoni laminin gamma-3 chain 0.073 0.2243 0.2243
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0008 0.0007 0.0002
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0008 0.0007 0.0166
Brugia malayi hypothetical protein 0.0012 0.0021 0.0016
Entamoeba histolytica deoxycytidyl transferase, putative 0.003 0.0077 0.6548
Brugia malayi hypothetical protein 0.0148 0.0441 0.0436
Echinococcus multilocularis cyclin G2 0.0008 0.0007 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0134 0.1402
Mycobacterium tuberculosis Conserved hypothetical protein 0.003 0.0077 0.1481
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.0196 0.0191
Brugia malayi TAR-binding protein 0.0091 0.0266 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0146 0.0434 0.0429
Trypanosoma brucei cyclin 3 0.0008 0.0007 0.0022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0146 0.0434 0.0429
Echinococcus multilocularis lipoxygenase domain containing protein 0.0012 0.0021 0.0016
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0007 0.0005 0.0005
Trypanosoma brucei DNA damage repair protein, putative 0.0009 0.0012 0.0076
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.0016 0.005
Echinococcus multilocularis nuclear receptor nhr 48 0.0069 0.0196 0.0191
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0028 0.0071 0.0066
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0016 0.0228
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0045 0.004
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0012 0.0076
Schistosoma mansoni 4-hydroxyphenylpyruvate dioxygenase 0.0049 0.0134 0.0134
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0054 0.1001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0146 0.0434 0.0429
Loa Loa (eye worm) hypothetical protein 0.0069 0.0196 0.019
Echinococcus multilocularis cyclin A3 4 0.0008 0.0007 0.0002
Echinococcus multilocularis cyclins 0.0032 0.0083 0.0078
Schistosoma mansoni notch 0.073 0.2243 0.2243
Echinococcus multilocularis cyclin t1 0.0008 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Loa Loa (eye worm) hypothetical protein 0.0069 0.0196 0.019
Loa Loa (eye worm) animal heme peroxidase 0.3236 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0146 0.0434 0.0434
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0032 0.0083 0.0078
Trypanosoma cruzi mitotic cyclin, putative 0.0008 0.0007 0.0023
Leishmania major glyoxalase I,trypanothione-dependent glyoxalase I 0.0049 0.0134 0.1365
Echinococcus multilocularis cyclins 0.0032 0.0083 0.0078
Echinococcus granulosus tar DNA binding protein 0.0091 0.0266 0.0261
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0044 0.042
Echinococcus multilocularis cyclin 0.0008 0.0007 0.0002
Trypanosoma brucei unspecified product 0.0021 0.0048 0.0448
Schistosoma mansoni hypothetical protein 0.0303 0.092 0.092
Trypanosoma cruzi cyclin 9, putative 0.0008 0.0007 0.0023
Echinococcus multilocularis cyclin b3 0.0032 0.0083 0.0078
Onchocerca volvulus 0.0069 0.0196 0.019
Loa Loa (eye worm) cyclin domain-containing protein 0.0008 0.0007 0.0002
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0007 0.0005 0.0376
Mycobacterium tuberculosis Conserved protein 0.0049 0.0134 0.2646
Echinococcus multilocularis neurogenic locus notch protein 4 0.073 0.2243 0.2239
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0146 0.0434 0.0429
Plasmodium vivax multidomain scavenger receptor, putative 0.0012 0.0021 0.1532
Toxoplasma gondii cyclin 4, putative 0.0008 0.0007 0.0032
Echinococcus granulosus cyclin dependent kinase 5 0.002 0.0044 0.0039
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0146 0.0434 0.0434
Echinococcus multilocularis lipoxygenase domain containing protein 0.0012 0.0021 0.0016
Toxoplasma gondii hypothetical protein 0.0008 0.0007 0.0032
Brugia malayi Animal haem peroxidase family protein 0.3236 1 1
Echinococcus granulosus dnaJ subfamily B 0.0303 0.092 0.0916
Loa Loa (eye worm) inositol-1 0.0023 0.0053 0.0048
Entamoeba histolytica cyclin family protein 0.0032 0.0083 0.7037
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0047 0.0128 0.2517
Brugia malayi EGF-like domain containing protein 0.073 0.2243 0.2239
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Trypanosoma brucei cyclin 9 0.0008 0.0007 0.0022
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0016 0.0228
Brugia malayi EGF-like domain containing protein 0.073 0.2243 0.2239
Trypanosoma brucei cdc2-related kinase 3 0.002 0.0044 0.0408
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0023 0.0053 0.0524
Loa Loa (eye worm) hypothetical protein 0.0049 0.0134 0.0129
Plasmodium falciparum thioredoxin reductase 0.0021 0.0047 0.3213
Schistosoma mansoni hypothetical protein 0.0008 0.0007 0.0007
Echinococcus multilocularis lysosomal alpha glucosidase 0.0088 0.0257 0.0252
Trypanosoma cruzi DNA polymerase eta, putative 0.0057 0.0159 0.1627
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0016 0.0228
Mycobacterium ulcerans hypothetical protein 0.0049 0.0134 0.2646
Echinococcus granulosus cyclins 0.0032 0.0083 0.0078
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.002 0.0044 0.0195
Schistosoma mansoni ap endonuclease 0.0023 0.0054 0.0054
Echinococcus multilocularis notch 0.073 0.2243 0.2239
Plasmodium falciparum DNA repair protein REV1, putative 0.0009 0.0012 0.0562
Echinococcus multilocularis cyclin dependent kinase 0.002 0.0044 0.0039
Plasmodium falciparum glyoxalase I 0.0049 0.0134 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0077 0.0752
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0028 0.0071 0.0065
Plasmodium vivax glyoxalase I, putative 0.0049 0.0134 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0009 0.0012 0.0055
Trichomonas vaginalis DNA polymerase eta, putative 0.003 0.0077 0.0785
Brugia malayi nuclear receptor NHR-67 0.0069 0.0196 0.0191
Echinococcus granulosus thioredoxin glutathione reductase 0.0021 0.0047 0.0042
Echinococcus granulosus neurogenic locus notch protein 0.073 0.2243 0.2239
Schistosoma mansoni nuclear hormone receptor 0.0069 0.0196 0.0196
Brugia malayi Animal haem peroxidase family protein 0.3236 1 1
Echinococcus multilocularis protein jagged 1 0.073 0.2243 0.2239
Loa Loa (eye worm) hypothetical protein 0.0069 0.0196 0.019
Brugia malayi glutathione reductase 0.0021 0.0047 0.0042
Plasmodium falciparum LCCL domain-containing protein 0.0012 0.0021 0.1201
Echinococcus granulosus cyclin t1 0.0008 0.0007 0.0002
Echinococcus multilocularis cyclin B3 1 0.0032 0.0083 0.0078
Echinococcus granulosus dna polymerase kappa 0.003 0.0077 0.0072
Brugia malayi Peroxidasin 0.3236 1 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0016 0.0118
Schistosoma mansoni inositol monophosphatase 0.0023 0.0053 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0146 0.0434 0.0429
Echinococcus granulosus protein jagged 2 0.073 0.2243 0.2239
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0069 0.0196 0.019
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0016 0.0116
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0023 0.0053 0.0238
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0016 0.0118
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0013 0.0022 0.0017
Onchocerca volvulus 0.073 0.2243 0.2239
Schistosoma mansoni DNA polymerase eta 0.0057 0.0159 0.0159
Loa Loa (eye worm) doublecortin family protein 0.0012 0.0021 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.0448
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0192 0.1969
Leishmania major trypanothione reductase 0.0021 0.0047 0.0438
Schistosoma mansoni notch 0.073 0.2243 0.2243
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0016 0.0118
Onchocerca volvulus Neurogenic locus notch homolog 0.073 0.2243 0.2239
Brugia malayi Nuclear hormone receptor-like 1 0.0146 0.0434 0.0429
Mycobacterium ulcerans hypothetical protein 0.0049 0.0134 0.2646
Echinococcus multilocularis lysosomal alpha glucosidase 0.0088 0.0257 0.0252
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0077 0.0752
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0028 0.0071 0.0066
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0016 0.0872
Trichomonas vaginalis cyclin D, putative 0.0032 0.0083 0.0847
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0044 0.0409
Schistosoma mansoni hypothetical protein 0.0206 0.0622 0.0622
Brugia malayi nuclear hormone receptor family member odr-7 0.0069 0.0196 0.0191
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.003 0.0077 0.1481
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0054 0.0049
Schistosoma mansoni hypothetical protein 0.073 0.2243 0.2243
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0039 0.0105 0.01
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0047 0.0438
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0012 0.0076
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0146 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0093 0.027 0.0265
Onchocerca volvulus 0.003 0.0076 0.0071
Brugia malayi Nuclear hormone receptor E75 0.0069 0.0196 0.0191
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0268 0.0813 0.0807
Trypanosoma cruzi cdc2-related kinase 1 0.002 0.0044 0.0415
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0069 0.0196 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0014 0.0102
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0069 0.0196 0.0191
Schistosoma mansoni notch 0.073 0.2243 0.2243
Leishmania major cytochrome p450-like protein 0.0011 0.0016 0.0118
Toxoplasma gondii glyoxalase I, putative 0.0049 0.0134 0.0599
Schistosoma mansoni hypothetical protein 0.0062 0.0176 0.0176
Schistosoma mansoni hypothetical protein 0.073 0.2243 0.2243
Echinococcus granulosus slit 2 protein 0.073 0.2243 0.2239
Trypanosoma brucei cdc2-related kinase 1 0.002 0.0044 0.0408
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.0221 0.0216
Echinococcus granulosus inositol monophosphatase 1 0.0023 0.0053 0.0048
Entamoeba histolytica cyclin, domain containing protein 0.0008 0.0007 0.0609
Loa Loa (eye worm) hypothetical protein 0.0146 0.0434 0.0429
Schistosoma mansoni notch 0.073 0.2243 0.2243
Echinococcus multilocularis importin subunit beta 1 0.0018 0.0039 0.0034
Brugia malayi Cyclin, N-terminal domain containing protein 0.0008 0.0007 0.0002
Onchocerca volvulus 0.0051 0.0141 0.0136
Echinococcus multilocularis fibropellin Ia 0.073 0.2243 0.2239
Schistosoma mansoni terminal deoxycytidyl transferase 0.003 0.0077 0.0077
Leishmania major alpha glucosidase II subunit, putative 0.002 0.0044 0.0409
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0016 0.0228
Loa Loa (eye worm) CYL-1 protein 0.0008 0.0007 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0091 0.0266 0.0266
Brugia malayi Bloom's syndrome protein homolog 0.0011 0.0016 0.0011
Onchocerca volvulus 0.0069 0.0196 0.019
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0054 0.0049
Schistosoma mansoni hypothetical protein 0.0011 0.0016 0.0016
Leishmania major cyclin 9, putative 0.0008 0.0007 0.0023
Echinococcus granulosus Polycystic kidney disease protein 0.0012 0.0021 0.0016
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0044 0.0118 0.1194
Mycobacterium tuberculosis Conserved protein 0.0049 0.0134 0.2646
Echinococcus multilocularis geminin 0.0206 0.0622 0.0617
Schistosoma mansoni hypothetical protein 0.0206 0.0622 0.0622
Echinococcus multilocularis neural cadherin 0.073 0.2243 0.2239
Entamoeba histolytica cyclin, putative 0.0044 0.0118 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0007
Schistosoma mansoni microsomal glutathione s-transferase 0.0114 0.0335 0.0335
Brugia malayi Pre-SET motif family protein 0.0268 0.0813 0.0808
Trichomonas vaginalis cyclin D, putative 0.0008 0.0007 0.0023
Onchocerca volvulus Peroxidasin homolog 0.3236 1 1
Loa Loa (eye worm) DR-78 0.0069 0.0196 0.019
Trichomonas vaginalis cyclin B, putative 0.0044 0.0118 0.1227
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0054 0.4016
Echinococcus granulosus fibropellin Ia 0.073 0.2243 0.2239
Loa Loa (eye worm) hypothetical protein 0.0069 0.0196 0.019
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0016 0.0228
Onchocerca volvulus Putative protein 0.0333 0.1014 0.1009
Brugia malayi hypothetical protein 0.0077 0.0221 0.0216
Echinococcus granulosus Nuclear hormone receptor HR96 0.0069 0.0196 0.0191
Echinococcus multilocularis Polycystic kidney disease protein 0.0012 0.0021 0.0016
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0016 0.0011
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0054 0.0509
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0033
Schistosoma mansoni hypothetical protein 0.0029 0.0073 0.0073
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0044 0.042
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0069 0.0196 0.0191
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0053 0.0503
Trichomonas vaginalis cyclins, putative 0.0008 0.0007 0.0023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.0073 0.0067
Loa Loa (eye worm) hypothetical protein 0.0069 0.0196 0.019
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0077 0.0764
Loa Loa (eye worm) RNA binding protein 0.0091 0.0266 0.0261
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0011 0.0016 0.0228
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.0073 0.0067
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.0073 0.0067
Brugia malayi photoreceptor-specific nuclear receptor 0.0146 0.0434 0.0429
Echinococcus multilocularis 0.0011 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0069 0.0196 0.019
Loa Loa (eye worm) hypothetical protein 0.0062 0.0176 0.0171
Echinococcus granulosus ecdysone induced protein 78C 0.0146 0.0434 0.0429
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0146 0.0434 0.0429
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0012 0.0077
Schistosoma mansoni coup transcription factor 0.0146 0.0434 0.0434
Loa Loa (eye worm) notch protein 0.073 0.2243 0.2239
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0054 0.1001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0146 0.0434 0.0429
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0007 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0012 0.0076
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0442 0.461
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0146 0.0434 0.0429
Loa Loa (eye worm) hypothetical protein 0.0146 0.0434 0.0429
Schistosoma mansoni nuclear receptor 0.0069 0.0196 0.0196
Onchocerca volvulus 0.073 0.2243 0.2239
Echinococcus multilocularis snurportin 1 0.0192 0.0579 0.0574
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0146 0.0434 0.0429
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Loa Loa (eye worm) hypothetical protein 0.3236 1 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0007 0.0006 0.0006
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0052 0.0144 1
Entamoeba histolytica cell division protein kinase 2, putative 0.002 0.0044 0.375
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.003 0.0077 0.0785
Brugia malayi conserved hypotetical protein 0.0069 0.0196 0.0191
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.0196 0.0191
Trichomonas vaginalis sucrase-isomaltase, putative 0.002 0.0044 0.042
Echinococcus multilocularis peroxidasin 0.3236 1 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0054 0.0516
Echinococcus granulosus thyroid hormone receptor alpha 0.0069 0.0196 0.0191
Plasmodium vivax thioredoxin reductase, putative 0.0021 0.0047 0.3468
Onchocerca volvulus Lactoylglutathione lyase homolog 0.0049 0.0134 0.0129
Mycobacterium ulcerans hypothetical protein 0.0049 0.0134 0.2646
Echinococcus granulosus protein jagged 1 0.073 0.2243 0.2239
Echinococcus multilocularis protein jagged 1 0.073 0.2243 0.2239
Trichomonas vaginalis cyclins, putative 0.0044 0.0118 0.1227
Brugia malayi hypothetical protein 0.0012 0.0021 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0038
Mycobacterium tuberculosis Probable oxidoreductase 0.0052 0.0144 0.2848
Echinococcus granulosus neurogenic locus protein delta 0.073 0.2243 0.2239
Echinococcus granulosus cyclin k 0.0008 0.0007 0.0002
Echinococcus granulosus cpg binding protein 0.0047 0.0129 0.0125
Schistosoma mansoni inositol monophosphatase 0.0023 0.0053 0.0053
Loa Loa (eye worm) histone methyltransferase 0.0015 0.003 0.0025
Brugia malayi ecdysone receptor 0.0069 0.0196 0.0191
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0077 0.0221 0.0221
Echinococcus multilocularis bloom syndrome protein 0.0011 0.0016 0.0011
Loa Loa (eye worm) cyclin domain-containing protein 0.0008 0.0007 0.0002
Echinococcus multilocularis tar DNA binding protein 0.0091 0.0266 0.0261
Trichomonas vaginalis cyclin B3, putative 0.0008 0.0007 0.0023
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0079 0.0227 0.0227
Schistosoma mansoni hypothetical protein 0.0008 0.0007 0.0007
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0016 0.0011
Echinococcus multilocularis cyclin dependent kinase 1 0.002 0.0044 0.0039
Brugia malayi Doublecortin family protein 0.0012 0.0021 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0146 0.0434 0.0429
Mycobacterium tuberculosis Conserved protein TB27.3 0.0049 0.0134 0.2646
Echinococcus multilocularis FTZ F1 alpha 0.0146 0.0434 0.0429
Loa Loa (eye worm) thioredoxin reductase 0.0021 0.0047 0.0041
Brugia malayi nuclear receptor NHR-88 0.0146 0.0434 0.0429
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0037 0.0097 0.0092
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0012 0.0076
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0069 0.0196 0.019
Loa Loa (eye worm) hypothetical protein 0.073 0.2243 0.2239
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0007 0.0005 0.0376
Brugia malayi steroid hormone receptor 0.0146 0.0434 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0146 0.0434 0.0429
Brugia malayi EGF-like domain containing protein 0.073 0.2243 0.2239
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0008 0.0007 0.0002
Onchocerca volvulus 0.3236 1 1
Echinococcus multilocularis cyclin dependent kinase 1 0.002 0.0044 0.0039
Loa Loa (eye worm) cyclin domain-containing protein 0.0008 0.0007 0.0002
Giardia lamblia Histone acetyltransferase GCN5 0.0021 0.0049 0.0195
Trichomonas vaginalis CMGC family protein kinase 0.002 0.0044 0.0426
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0077 0.0764
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0053 0.051
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0049 0.0134 0.1365
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0016 0.0011
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0016 0.0228
Echinococcus granulosus peroxidasin 0.3236 1 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0016 0.0228
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0039 0.0105 0.0105
Trichomonas vaginalis cyclins, putative 0.0044 0.0118 0.1227
Brugia malayi Thioredoxin reductase 0.0021 0.0047 0.0042
Mycobacterium ulcerans hypothetical protein 0.0049 0.0134 0.2646
Mycobacterium ulcerans hypothetical protein 0.0049 0.0134 0.2646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0146 0.0434 0.0429
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0054 0.0049
Trypanosoma brucei glucosidase, putative 0.002 0.0044 0.0403
Trichomonas vaginalis cyclin A, putative 0.0008 0.0007 0.0023
Brugia malayi Calcium binding EGF domain containing protein 0.073 0.2243 0.2239
Leishmania major DNA polymerase eta, putative 0.0036 0.0094 0.094
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0007 0.0023
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0119 0.1206
Echinococcus granulosus importin subunit beta 1 0.0018 0.0039 0.0034
Brugia malayi nuclear receptor RXR 0.0069 0.0196 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0146 0.0434 0.0429
Loa Loa (eye worm) hypothetical protein 0.0039 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0136 0.0403 0.0398
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0016 0.0011
Loa Loa (eye worm) cyclin domain-containing protein 0.0115 0.034 0.0335
Trypanosoma brucei mitotic cyclin 6 0.0044 0.0118 0.1177
Loa Loa (eye worm) cyclin domain-containing protein 0.0008 0.0007 0.0002
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0192 0.3817
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0016 0.0228
Trichomonas vaginalis cyclins, putative 0.0044 0.0118 0.1227
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0012
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0011 0.0016 0.0872
Echinococcus granulosus cyclin dependent kinase 1 0.002 0.0044 0.0039
Loa Loa (eye worm) cyclin domain-containing protein 0.0008 0.0007 0.0002
Echinococcus granulosus cyclin B 0.0044 0.0118 0.0113
Schistosoma mansoni DNA helicase recq5 0.0011 0.0016 0.0016
Echinococcus multilocularis thyroid hormone receptor alpha 0.0146 0.0434 0.0429
Leishmania major mitotic cyclin, putative 0.0008 0.0007 0.0023
Brugia malayi RNA recognition motif domain containing protein 0.0091 0.0266 0.0261
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0077 0.0221 0.0216
Brugia malayi tailless protein 0.0069 0.0196 0.0191
Brugia malayi 4-hydroxyphenylpyruvate dioxygenase family protein 0.0333 0.1014 0.1009
Trypanosoma brucei mitotic cyclin 0.0008 0.0007 0.0022
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.0073 0.0067
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0021 0.0047 0.085
Schistosoma mansoni slit 0.073 0.2243 0.2243
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0313 0.0952 0.9853

Activities

Activity type Activity value Assay description Source Reference
Clearance (ADMET) = 10 ml min-1 kg-1 Plasma clearence at 1 hr after a intravenous dose 0.5 mg/kg in rats ChEMBL. 15946843
F (ADMET) = 33 % Oral bioavailability in rat at 1 hr (dose 0.5 mg/kg i.v.) ChEMBL. 15946843
IC50 (binding) = -7.8 Displacement of [125I]CRF from human recombinant CRF1 receptor expressed in CHO cell membrane ChEMBL. 17629700
Log IC50 (binding) = 7.8 Displacement of [125I]CRF from human recombinant CRF1 receptor expressed in CHO cell membrane ChEMBL. 17629700
Log IC50 (binding) = 7.85 Displacement of [125I]-o-CRF from recombinant human CRF receptors expressed in Chinese Hamster Ovary (CHO) cell membranes ChEMBL. 15946843
Penetration (ADMET) = 1.3 Brain/Plasma ratio level at 1 hr after a intravenous dose 0.5 mg/kg in rats ChEMBL. 15946843

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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