Detailed information for compound 413581

Basic information

Technical information
  • TDR Targets ID: 413581
  • Name: 5-[(E)-cyclohexylmethoxyiminomethyl]-6-[(4-fl uoro-2-methyl-1H-indol-5-yl)oxy]pyrimidin-4-a mine
  • MW: 397.446 | Formula: C21H24FN5O2
  • H donors: 2 H acceptors: 2 LogP: 4.76 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc2c([nH]1)ccc(c2F)Oc1ncnc(c1/C=N/OCC1CCCCC1)N
  • InChi: 1S/C21H24FN5O2/c1-13-9-15-17(27-13)7-8-18(19(15)22)29-21-16(20(23)24-12-25-21)10-26-28-11-14-5-3-2-4-6-14/h7-10,12,14,27H,2-6,11H2,1H3,(H2,23,24,25)/b26-10+
  • InChiKey: HCPZISVZYWKEQP-NSKAYECMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(E)-cyclohexylmethoxyiminomethyl]-6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-4-pyrimidinamine
  • [5-[(E)-cyclohexylmethyloximinomethyl]-6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]pyrimidin-4-yl]amine
  • [5-[(E)-cyclohexylmethoxyiminomethyl]-6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]pyrimidin-4-yl]amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0612 0.1296 0.259
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.0405 0.0862
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0297 0.0405 0.0494
Schistosoma mansoni hypothetical protein 0.0172 0.0053 0.0086
Echinococcus multilocularis mitogen activated protein kinase 0.0404 0.0708 0.0972
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0259 0.0298 0.0571
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.1639 0.4197 0.5765
Echinococcus multilocularis serine:threonine protein kinase N2 0.1503 0.3812 0.5237
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0763 0.1723 0.2367
Brugia malayi RhoGAP domain containing protein 0.0192 0.0109 0.0121
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0923 0.2174 0.2174
Trichomonas vaginalis STE family protein kinase 0.0302 0.0421 0.0511
Echinococcus multilocularis casein kinase I alpha 0.037 0.0612 0.0841
Schistosoma mansoni tyrosine kinase 0.1091 0.265 0.5803
Brugia malayi Immunoglobulin I-set domain containing protein 0.0248 0.0269 0.0323
Echinococcus multilocularis Immunoglobulin 0.0318 0.0466 0.064
Loa Loa (eye worm) hypothetical protein 0.0305 0.0429 0.0525
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0299 0.0411 0.0411
Schistosoma mansoni tyrosine kinase 0.1469 0.3717 0.8152
Echinococcus granulosus calcium activated potassium channel 0.0405 0.0711 0.0711
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.1508 0.3826 0.3826
Trichomonas vaginalis CAMK family protein kinase 0.0299 0.0411 0.0497
Loa Loa (eye worm) hypothetical protein 0.0318 0.0466 0.0571
Schistosoma mansoni diacylglycerol kinase theta 0.0192 0.0109 0.0211
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0658 0.1425 0.1425
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Loa Loa (eye worm) CAMK protein kinase 0.0248 0.0269 0.0323
Loa Loa (eye worm) protein kinase domain-containing protein 0.0498 0.0975 0.1213
Echinococcus granulosus suppressor of cytokine signaling 7 0.0158 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0612 0.1296 0.1619
Trichomonas vaginalis AGC family protein kinase 0.122 0.3013 0.3934
Echinococcus granulosus twitchin 0.0528 0.1059 0.1059
Echinococcus multilocularis mitogen activated protein kinase 11 0.067 0.1459 0.2004
Echinococcus multilocularis tensin 0.0158 0.0013 0.0018
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0233 0.0227 0.0412
Echinococcus granulosus cyclin dependent kinase 9 0.0192 0.0111 0.0111
Echinococcus multilocularis SHC transforming protein 3 0.0158 0.0013 0.0018
Schistosoma mansoni unc-13 (munc13) 0.0206 0.0151 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0283 0.0365 0.0437
Schistosoma mansoni hypothetical protein 0.0273 0.034 0.0718
Echinococcus multilocularis activin receptor type 0.0701 0.1547 0.2124
Schistosoma mansoni serine/threonine protein kinase 0.0525 0.1051 0.2283
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0259 0.0298 0.0571
Entamoeba histolytica PH domain containing protein kinase, putative 0.0259 0.0298 0.0375
Entamoeba histolytica protein kinase, putative 0.0283 0.0365 0.0464
Loa Loa (eye worm) hypothetical protein 0.0192 0.0109 0.0121
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Loa Loa (eye worm) hypothetical protein 0.0192 0.0109 0.0121
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0202 0.0137 0.0156
Echinococcus multilocularis dual specificity 0.0347 0.0548 0.0753
Schistosoma mansoni tyrosine kinase 0.0944 0.2234 0.4887
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0644 0.1387 0.1387
Schistosoma mansoni protein kinase 0.0772 0.1747 0.3815
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1091 0.265 0.265
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Schistosoma mansoni growth factor receptor-bound protein 0.0282 0.0364 0.0772
Entamoeba histolytica PH domain containing protein kinase, putative 0.1766 0.4557 0.5984
Schistosoma mansoni tyrosine kinase 0.1091 0.265 0.5803
Echinococcus granulosus tyrosine protein kinase Fyn 0.0763 0.1722 0.1722
Trypanosoma brucei protein kinase, putative 0.054 0.1092 0.139
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0259 0.0298 0.0341
Trichomonas vaginalis CMGC family protein kinase 0.0247 0.0265 0.0305
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0806 0.1844 0.231
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0264 0.0314 0.0314
Echinococcus multilocularis titin 0.0248 0.0269 0.037
Brugia malayi Protein kinase domain containing protein 0.0457 0.0858 0.1065
Echinococcus multilocularis RNA directed DNA polymerase 0.0291 0.0388 0.0533
Trichomonas vaginalis CK1 family protein kinase 0.037 0.0612 0.0763
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0847 0.1961 0.2457
Loa Loa (eye worm) hypothetical protein 0.1286 0.32 0.402
Leishmania major protein kinase, putative 0.0279 0.0354 0.1017
Echinococcus multilocularis twitchin 0.021 0.016 0.022
Giardia lamblia Kinase, PLK 0.0871 0.2027 0.478
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0337 0.052 0.052
Giardia lamblia Kinase, CMGC CDK 0.0674 0.1472 0.3444
Loa Loa (eye worm) TK/FER protein kinase 0.0305 0.0429 0.0525
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0248 0.0269 0.0323
Schistosoma mansoni tyrosine kinase 0.0221 0.0191 0.0391
Trichomonas vaginalis CAMK family protein kinase 0.088 0.2053 0.2666
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0777 0.1762 0.2207
Schistosoma mansoni serine/threonine protein kinase 0.0339 0.0525 0.1127
Trichomonas vaginalis AGC family protein kinase 0.0283 0.0365 0.0437
Entamoeba histolytica protein kinase, putative 0.0259 0.0298 0.0375
Echinococcus multilocularis hypothetical protein 0.0273 0.034 0.0467
Echinococcus granulosus mitogen activated protein kinase 0.0404 0.0708 0.0708
Echinococcus granulosus serine threonine protein kinase nrc 0.1639 0.4197 0.4197
Giardia lamblia Kinase, CDC7 0.0247 0.0265 0.054
Schistosoma mansoni tyrosine kinase 0.0944 0.2234 0.4887
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0279 0.0356 0.0432
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1348 0.3374 0.4635
Brugia malayi Immunoglobulin I-set domain containing protein 0.0178 0.0071 0.0072
Echinococcus granulosus casein kinase I alpha 0.037 0.0612 0.0612
Echinococcus granulosus tyrosine protein kinase Src64B 0.0763 0.1722 0.1722
Schistosoma mansoni serine/threonine protein kinase 0.1042 0.251 0.5495
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0581 0.1208 0.1507
Echinococcus multilocularis myosin iiia 0.0292 0.0393 0.054
Onchocerca volvulus 0.091 0.2139 0.4291
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0178 0.0071 0.0097
Schistosoma mansoni rap gtpase-activating protein 0.0326 0.0489 0.1047
Echinococcus multilocularis nervana 2 0.1508 0.3826 0.5256
Schistosoma mansoni protein kinase 0.1143 0.2797 0.6127
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0264 0.0314 0.038
Loa Loa (eye worm) hypothetical protein 0.0452 0.0845 0.105
Trypanosoma cruzi casein kinase, delta isoform, putative 0.037 0.0612 0.1266
Trypanosoma brucei cdc2-related kinase 3 0.0674 0.1472 0.1892
Schistosoma mansoni protein kinase 0.0445 0.0825 0.1786
Schistosoma mansoni tyrosine kinase 0.0424 0.0764 0.1651
Loa Loa (eye worm) hypothetical protein 0.0276 0.0348 0.0422
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0259 0.0298 0.0341
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.126 0.3126 0.4079
Giardia lamblia Aurora kinase 0.0547 0.1112 0.2577
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0547 0.1112 0.1447
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0259 0.0298 0.0358
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0297 0.0405 0.0557
Brugia malayi Protein kinase domain containing protein 0.0847 0.1961 0.2457
Schistosoma mansoni serine/threonine protein kinase 0.0477 0.0914 0.1982
Onchocerca volvulus Tyrosine kinase homolog 0.1912 0.4967 1
Schistosoma mansoni tyrosine kinase 0.0808 0.1851 0.4044
Schistosoma mansoni tyrosine kinase 0.0287 0.0378 0.0801
Trichomonas vaginalis CAMK family protein kinase 0.0337 0.052 0.0642
Trichomonas vaginalis CMGC family protein kinase 0.0404 0.0708 0.0889
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0279 0.0354 0.0436
Echinococcus multilocularis expressed protein 0.0233 0.0227 0.0311
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0384 0.0653 0.0806
Brugia malayi Stress-activated protein kinase jnk-1 0.1118 0.2726 0.3423
Schistosoma mansoni serine/threonine protein kinase 0.1257 0.3118 0.6833
Onchocerca volvulus 0.0247 0.0265 0.0508
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0773 0.175 0.2191
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0259 0.0298 0.0571
Onchocerca volvulus 0.0178 0.0069 0.0113
Schistosoma mansoni serine/threonine protein kinase 0.1624 0.4154 0.9114
Echinococcus multilocularis SH2 motif 0.0158 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0449 0.0837 0.1039
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0455 0.0853 0.1799
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0183 0.0085 0.009
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Echinococcus multilocularis serine:threonine protein kinase 38 0.1211 0.2987 0.4103
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Brugia malayi Furin-like cysteine rich region family protein 0.159 0.4059 0.5104
Loa Loa (eye worm) TK protein kinase 0.0486 0.0941 0.1171
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.0405 0.0862
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0158 0.0013 0.0018
Trypanosoma brucei polo-like protein kinase 0.0871 0.2027 0.2626
Echinococcus granulosus fibroblast growth factor receptor 4 0.0772 0.1748 0.1748
Brugia malayi Variant SH3 domain containing protein 0.0276 0.0348 0.0422
Echinococcus granulosus protein kinase c epsilon type 0.1709 0.4396 0.4396
Echinococcus granulosus tyrosine protein kinase 0.0635 0.1362 0.1362
Trichomonas vaginalis AGC family protein kinase 0.2846 0.7606 1
Toxoplasma gondii aurora kinase 0.0547 0.1112 0.1487
Loa Loa (eye worm) hypothetical protein 0.0178 0.0071 0.0072
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0477 0.0914 0.1136
Schistosoma mansoni tyrosine kinase 0.1309 0.3265 0.7156
Loa Loa (eye worm) AGC/PKN protein kinase 0.1624 0.4154 0.5225
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.1129 0.2755 0.3785
Echinococcus multilocularis protein kinase c iota type 0.1661 0.4259 0.585
Schistosoma mansoni kinase 0.0183 0.0085 0.0158
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0246 0.0261 0.0546
Loa Loa (eye worm) TK/FAK protein kinase 0.1485 0.3762 0.4729
Echinococcus granulosus tyrosine protein kinase Lyn 0.0894 0.2092 0.2092
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0337 0.052 0.064
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0221 0.0191 0.0191
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0477 0.0914 0.1136
Entamoeba histolytica serine/threonine protein kinase, putative 0.0168 0.004 0.0036
Trichomonas vaginalis CMGC family protein kinase 0.0247 0.0265 0.0305
Trypanosoma cruzi casein kinase, putative 0.037 0.0612 0.1266
Brugia malayi Protein kinase domain containing protein 0.1485 0.3762 0.4729
Loa Loa (eye worm) hypothetical protein 0.0371 0.0614 0.0758
Echinococcus multilocularis tyrosine protein kinase shark 0.074 0.1657 0.2277
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.157 0.4001 0.5031
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0206 0.0151 0.0207
Brugia malayi Protein kinase domain containing protein 0.081 0.1856 0.2324
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Schistosoma mansoni protein kinase 0.0763 0.1723 0.3762
Brugia malayi map kinase activated protein kinase protein 2 0.1257 0.3118 0.3917
Loa Loa (eye worm) hypothetical protein 0.0488 0.0946 0.1177
Loa Loa (eye worm) hypothetical protein 0.0357 0.0575 0.0709
Loa Loa (eye worm) hypothetical protein 0.0192 0.0109 0.0121
Brugia malayi cyclin-dependent kinase 9 0.0183 0.0085 0.009
Loa Loa (eye worm) TK/EPH protein kinase 0.0401 0.0701 0.0868
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0337 0.052 0.0666
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0158 0.0013 0.0018
Echinococcus granulosus SH2 motif 0.0158 0.0013 0.0013
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0547 0.1112 0.1527
Echinococcus granulosus tyrosine protein kinase Src42A 0.0503 0.0988 0.0988
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0801 0.1829 0.2512
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0326 0.0489 0.1047
Schistosoma mansoni protein kinase 0.0547 0.1112 0.2417
Plasmodium falciparum protein serine/threonine kinase-1 0.0455 0.0853 0.1955
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.1211 0.2987 0.4103
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0326 0.0489 0.0489
Entamoeba histolytica protein kinase domain containing protein 0.054 0.1092 0.1421
Trichomonas vaginalis CMGC family protein kinase 0.0777 0.1762 0.2283
Echinococcus multilocularis protein kinase c epsilon type 0.1709 0.4396 0.6038
Loa Loa (eye worm) hypothetical protein 0.0449 0.0837 0.1039
Echinococcus multilocularis death associated protein kinase 1 0.273 0.728 1
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0326 0.0489 0.0994
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.126 0.3126 0.3126
Brugia malayi serine/threonine-protein kinase plk-2 0.0871 0.2027 0.2541
Brugia malayi Protein kinase domain containing protein 0.0283 0.0365 0.0444
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0158 0.0013 0.0018
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0547 0.1112 0.1447
Trypanosoma cruzi Protein kinase B 0.1766 0.4557 1
Plasmodium falciparum casein kinase 2, alpha subunit 0.0777 0.1762 0.4143
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1257 0.3118 0.3118
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0264 0.0314 0.038
Schistosoma mansoni hypothetical protein 0.0172 0.0053 0.0086
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0763 0.1722 0.2365
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0302 0.0421 0.1233
Echinococcus granulosus calcium dependent protein kinase 0.0206 0.0149 0.0149
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0763 0.1722 0.2365
Echinococcus multilocularis cyclin dependent kinase 7 0.021 0.0162 0.0222
Loa Loa (eye worm) hypothetical protein 0.04 0.0697 0.0863
Echinococcus granulosus activated cdc42 kinase 1 0.0338 0.0523 0.0523
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.1639 0.4197 0.4197
Loa Loa (eye worm) TK/FER protein kinase 0.0305 0.0429 0.0525
Loa Loa (eye worm) hypothetical protein 0.0379 0.0638 0.0789
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0806 0.1844 0.231
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.054 0.1092 0.15
Echinococcus multilocularis neuroglian 0.0397 0.0688 0.0945
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.054 0.1092 0.2328
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0292 0.0391 0.0476
Echinococcus granulosus Rac GTPase activating protein 1 0.0192 0.0109 0.0109
Trichomonas vaginalis AGC family protein kinase 0.138 0.3465 0.4531
Echinococcus multilocularis CDC7 cell division cycle 7 0.0247 0.0265 0.0364
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Brugia malayi Protein kinase domain containing protein 0.0338 0.0523 0.0643
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.157 0.4001 0.5496
Echinococcus multilocularis rac serine:threonine kinase 0.1766 0.4557 0.626
Brugia malayi Pleckstrin Homology Domain 0.0319 0.0469 0.0575
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Loa Loa (eye worm) hypothetical protein 0.0326 0.0489 0.06
Trichomonas vaginalis AGC family protein kinase 0.0547 0.1112 0.1423
Onchocerca volvulus 0.0641 0.1379 0.2757
Loa Loa (eye worm) TK/FER protein kinase 0.0305 0.0429 0.0525
Echinococcus multilocularis serine:threonine protein kinase 0.0384 0.0653 0.0897
Plasmodium vivax glycogen synthase kinase 3, putative 0.054 0.1092 0.253
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0259 0.0298 0.0571
Schistosoma mansoni serine/threonine-protein kinase 0.1766 0.4557 1
Entamoeba histolytica protein kinase, putative 0.0347 0.0548 0.0704
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Echinococcus multilocularis serine:threonine protein kinase 3 0.0829 0.1909 0.2622
Leishmania major protein kinase, putative 0.0259 0.0298 0.0836
Echinococcus granulosus serine:threonine protein kinase mig 15 0.064 0.1376 0.1376
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0302 0.0421 0.0842
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0326 0.0489 0.1047
Toxoplasma gondii diacylglycerol kinase, putative 0.0192 0.0109 0.0096
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0279 0.0356 0.0432
Brugia malayi Protein kinase domain containing protein 0.1166 0.2859 0.3591
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Loa Loa (eye worm) TK/FER protein kinase 0.0305 0.0429 0.0525
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0297 0.0405 0.0557
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.067 0.1459 0.1824
Leishmania major protein kinase A catalytic subunit isoform 1 0.126 0.3126 1
Echinococcus granulosus protein kinase C gamma type 0.1516 0.3849 0.3849
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0601 0.1264 0.1577
Loa Loa (eye worm) hypothetical protein 0.0612 0.1296 0.1619
Schistosoma mansoni tyrosine kinase 0.0944 0.2234 0.4887
Schistosoma mansoni atypical protein kinase C 0.168 0.4312 0.9461
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1257 0.3118 0.3917
Brugia malayi hypothetical protein 0.0735 0.1642 0.2055
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0966 0.2297 0.3155
Echinococcus granulosus tyrosine protein kinase ABL1 0.0966 0.2297 0.2297
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0458 0.086 0.1182
Onchocerca volvulus 0.0256 0.029 0.0559
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0292 0.0393 0.0781
Schistosoma mansoni serine/threonine protein kinase 0.0498 0.0975 0.2117
Loa Loa (eye worm) TK/FER protein kinase 0.0305 0.0429 0.0525
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0259 0.0298 0.0836
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0477 0.0914 0.1256
Schistosoma mansoni serine/threonine protein kinase 0.0801 0.1829 0.3996
Echinococcus multilocularis NCK adaptor protein 0.0282 0.0364 0.05
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0708 0.1567 0.2153
Schistosoma mansoni serine/threonine protein kinase 0.0283 0.0365 0.0775
Entamoeba histolytica protein kinase domain containing protein 0.0477 0.0914 0.1186
Echinococcus multilocularis tyrosine protein kinase Blk 0.0644 0.1387 0.1906
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.1286 0.32 0.402
Trichomonas vaginalis CMGC family protein kinase 0.0347 0.0548 0.0679
Loa Loa (eye worm) hypothetical protein 0.0641 0.1379 0.1723
Echinococcus multilocularis cyclin dependent kinase 1 0.0674 0.1472 0.2022
Echinococcus multilocularis tyrosine protein kinase Srms 0.0644 0.1387 0.1906
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0654 0.1415 0.1415
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0763 0.1723 0.1723
Trichomonas vaginalis STE family protein kinase 0.0302 0.0421 0.0511
Loa Loa (eye worm) casein kinase 0.0367 0.0604 0.0745
Entamoeba histolytica protein kinase, putative 0.0233 0.0227 0.0281
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Loa Loa (eye worm) hypothetical protein 0.0324 0.0482 0.0591
Entamoeba histolytica protein kinase, putative 0.0229 0.0214 0.0265
Entamoeba histolytica diacylglycerol kinase, putative 0.0192 0.0109 0.0126
Echinococcus granulosus geminin 0.0172 0.0053 0.0053
Echinococcus multilocularis mitogen activated protein kinase 14 0.067 0.1459 0.2004
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0404 0.0708 0.1477
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.037 0.0612 0.0756
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0347 0.0548 0.0675
Echinococcus granulosus protein tyrosine kinase 0.1469 0.3717 0.3717
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0302 0.0421 0.0514
Loa Loa (eye worm) TK protein kinase 0.0635 0.1362 0.1702
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Loa Loa (eye worm) TK/FER protein kinase 0.0923 0.2174 0.2727
Schistosoma mansoni serine/threonine protein kinase 0.0338 0.0523 0.1121
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0453 0.0847 0.1119
Plasmodium falciparum calcium-dependent protein kinase 3 0.0337 0.052 0.1155
Echinococcus granulosus roundabout 2 0.0178 0.0071 0.0071
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0259 0.0298 0.062
Echinococcus granulosus SH2 motif 0.0158 0.0013 0.0013
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.126 0.3126 0.7424
Loa Loa (eye worm) hypothetical protein 0.0326 0.0489 0.06
Trichomonas vaginalis STE family protein kinase 0.0229 0.0214 0.0238
Echinococcus multilocularis cyclin dependent kinase 19 0.0282 0.0365 0.0501
Schistosoma mansoni serine/threonine protein kinase 0.0282 0.0365 0.0773
Onchocerca volvulus 0.0247 0.0265 0.0508
Echinococcus multilocularis mitogen activated protein kinase 11 0.067 0.1459 0.2004
Entamoeba histolytica protein kinase domain containing protein 0.0279 0.0354 0.0449
Brugia malayi protein unc-22 0.0248 0.0269 0.0323
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.1118 0.2726 0.3423
Trichomonas vaginalis AGC family protein kinase 0.2846 0.7606 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0226 0.0205 0.0205
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0337 0.052 0.0666
Echinococcus multilocularis nervana 2 0.1508 0.3826 0.5256
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.035 0.0555 0.1193
Echinococcus granulosus mitogen activated protein kinase 3 0.0404 0.0708 0.0708
Giardia lamblia Kinase, AGC AKT 0.049 0.0952 0.2193
Echinococcus multilocularis unc 13 (munc13) 0.0206 0.0151 0.0207
Loa Loa (eye worm) TK/ALK protein kinase 0.1221 0.3015 0.3788
Plasmodium vivax casein kinase 1, putative 0.037 0.0612 0.1376
Echinococcus granulosus protein kinase c eta type 0.0192 0.0109 0.0109
Echinococcus granulosus defective proboscis extension response 0.0318 0.0466 0.0466
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0292 0.0393 0.05
Trichomonas vaginalis CAMK family protein kinase 0.0871 0.2027 0.2632
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0292 0.0393 0.0781
Echinococcus granulosus TGF-beta receptor type-1 0.0214 0.0172 0.0172
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Echinococcus granulosus serine/threonine protein kinase 0.1766 0.4557 0.4557
Echinococcus multilocularis SH2 motif 0.0158 0.0013 0.0018
Brugia malayi casein kinase 1, delta 0.037 0.0612 0.0756
Entamoeba histolytica protein kinase, putative 0.0352 0.0562 0.0722
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Schistosoma mansoni protein kinase 0.0297 0.0405 0.0862
Brugia malayi Protein kinase domain containing protein 0.2964 0.7939 1
Loa Loa (eye worm) hypothetical protein 0.0297 0.0405 0.0494
Trichomonas vaginalis CAMK family protein kinase 0.0871 0.2027 0.2632
Entamoeba histolytica serine/threonine protein kinase, putative 0.0297 0.0405 0.0516
Loa Loa (eye worm) hypothetical protein 0.0199 0.0131 0.0148
Echinococcus granulosus activin receptor type 0.0701 0.1547 0.1547
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0404 0.0708 0.2162
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0158 0.0013 0.0018
Trypanosoma cruzi casein kinase II, putative 0.0777 0.1762 0.3813
Echinococcus multilocularis raf serine:threonine protein kinase 0.0339 0.0525 0.0722
Brugia malayi Protein kinase domain containing protein 0.1252 0.3105 0.39
Echinococcus granulosus tyrosine protein kinase Blk 0.0644 0.1387 0.1387
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.081 0.1856 0.2549
Echinococcus granulosus SHC transforming protein 3 0.0158 0.0013 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0871 0.2027 0.2632
Echinococcus granulosus growth factor receptor bound protein 2 0.0282 0.0364 0.0364
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.1166 0.2859 0.3591
Schistosoma mansoni tyrosine kinase 0.1309 0.3265 0.7156
Loa Loa (eye worm) AGC/AKT protein kinase 0.2846 0.7606 0.9579
Brugia malayi protein kinase C II. 0.1709 0.4396 0.5529
Loa Loa (eye worm) CMGC/GSK protein kinase 0.054 0.1092 0.1361
Schistosoma mansoni adapter molecule crk 0.0276 0.0348 0.0735
Loa Loa (eye worm) TK/FER protein kinase 0.0305 0.0429 0.0525
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.126 0.3126 0.4079
Echinococcus multilocularis N chimaerin 0.035 0.0555 0.0763
Schistosoma mansoni protein kinase 0.0279 0.0354 0.075
Echinococcus granulosus casein kinase ii subunit alpha 0.0777 0.1762 0.1762
Giardia lamblia Kinase, AGC PKA 0.126 0.3126 0.7424
Loa Loa (eye worm) RhoGAP domain-containing protein 0.035 0.0555 0.0684
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.126 0.3126 0.4294
Entamoeba histolytica serine/threonine protein kinase, putative 0.0871 0.2027 0.2652
Loa Loa (eye worm) hypothetical protein 0.0612 0.1296 0.1619
Trichomonas vaginalis CMGC family protein kinase 0.0777 0.1762 0.2283
Echinococcus granulosus cyclin dependent kinase 19 0.0282 0.0365 0.0365
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0337 0.052 0.052
Trichomonas vaginalis CMGC family protein kinase 0.0455 0.0853 0.1081
Giardia lamblia Kinase, CMGC CK2 0.0777 0.1762 0.4143
Schistosoma mansoni serine/threonine protein kinase 0.0674 0.1472 0.3211
Schistosoma mansoni tyrosine kinase 0.0763 0.1722 0.3759
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.157 0.4001 0.4001
Trypanosoma cruzi cdc2-related kinase 1 0.0674 0.1472 0.317
Echinococcus multilocularis 0.0158 0.0013 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Echinococcus multilocularis 0.0442 0.0816 0.1121
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0178 0.0071 0.0071
Brugia malayi protein-tyrosine kinase 0.0644 0.1387 0.1734
Echinococcus granulosus myotubularin protein 13 0.0319 0.0469 0.0469
Echinococcus granulosus epidermal growth factor receptor 0.159 0.4059 0.4059
Plasmodium vivax serine/threonine protein kinase, putative 0.0233 0.0227 0.0448
Brugia malayi Protein kinase domain containing protein 0.1672 0.4291 0.5397
Echinococcus multilocularis serine threonine protein kinase 0.1516 0.3849 0.5287
Brugia malayi Fibronectin type III domain containing protein 0.0357 0.0575 0.0709
Brugia malayi Protein kinase domain containing protein 0.1286 0.32 0.402
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0777 0.1762 0.4143
Brugia malayi Variant SH3 domain containing protein 0.03 0.0415 0.0506
Echinococcus granulosus ephrin type A receptor 4 A 0.0347 0.0547 0.0547
Entamoeba histolytica protein kinase, putative 0.0259 0.0298 0.0375
Echinococcus multilocularis geminin 0.0172 0.0053 0.0072
Brugia malayi Ras association domain family 1 isoform A 0.0192 0.0109 0.0121
Loa Loa (eye worm) TK/EGFR protein kinase 0.159 0.4059 0.5104
Brugia malayi Protein kinase domain containing protein 0.0498 0.0975 0.1213
Giardia lamblia Kinase, CMGC SRPK 0.0233 0.0227 0.0448
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0199 0.0129 0.0196
Trichomonas vaginalis CMGC family protein kinase 0.0347 0.0548 0.0679
Giardia lamblia Kinase, NEK 0.0453 0.0847 0.1939
Brugia malayi Protein kinase c protein 2 0.0628 0.1342 0.1676
Brugia malayi Doublecortin family protein 0.0371 0.0616 0.0761
Entamoeba histolytica PH domain containing protein kinase, putative 0.1766 0.4557 0.5984
Echinococcus granulosus protein kinase 0.0445 0.0825 0.0825
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0547 0.1112 0.1112
Brugia malayi Protein kinase domain containing protein 0.0384 0.0653 0.0806
Echinococcus multilocularis mitogen activated protein kinase 3 0.0404 0.0708 0.0972
Echinococcus multilocularis Glutaredoxin protein 5 0.1508 0.3826 0.5256
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0772 0.1748 0.2402
Echinococcus granulosus cyclin dependent kinase 0.0674 0.1472 0.1472
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0708 0.1567 0.1567
Echinococcus granulosus pdz domain containing protein 0.0164 0.0029 0.0029
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0297 0.0405 0.1182
Giardia lamblia Kinase, CAMK CAMKL 0.0306 0.0431 0.0939
Echinococcus granulosus casein kinase I delta 0.037 0.0612 0.0612
Trichomonas vaginalis AGC family protein kinase 0.2846 0.7606 1
Loa Loa (eye worm) hypothetical protein 0.064 0.1376 0.1719
Toxoplasma gondii casein kinase I 0.037 0.0612 0.0794
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0282 0.0365 0.0443
Trichomonas vaginalis CMGC family protein kinase 0.0404 0.0708 0.0889
Schistosoma mansoni protein kinase 0.1166 0.2859 0.6264
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0829 0.1909 0.2391
Plasmodium falciparum protein kinase 5 0.0674 0.1472 0.3444
Loa Loa (eye worm) RasGEF domain-containing protein 0.0192 0.0109 0.0121
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0871 0.2027 0.2541
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.126 0.3126 0.3927
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0525 0.1051 0.1335
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0289 0.0384 0.0489
Loa Loa (eye worm) hypothetical protein 0.0165 0.0034 0.0026
Brugia malayi Protein kinase domain containing protein 0.02 0.0131 0.0149
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0772 0.1748 0.1748
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Echinococcus multilocularis dual specificity protein kinase clk2 0.0455 0.0853 0.1172
Entamoeba histolytica protein kinase domain containing protein 0.0183 0.0085 0.0094
Entamoeba histolytica protein kinase, putative 0.1211 0.2987 0.3917
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.1709 0.4396 0.5529
Loa Loa (eye worm) AGC/PKG protein kinase 0.0338 0.0523 0.0643
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0477 0.0914 0.0914
Brugia malayi STE20-like kinase MST 0.0829 0.1909 0.2391
Brugia malayi Protein kinase domain 0.0297 0.0405 0.0494
Trichomonas vaginalis CMGC family protein kinase 0.054 0.1092 0.1397
Brugia malayi Protein kinase domain containing protein 0.0305 0.0429 0.0525
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Leishmania major casein kinase II, putative 0.0777 0.1762 0.5581
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0233 0.0227 0.0269
Trichomonas vaginalis STE family protein kinase 0.0297 0.0405 0.049
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.1143 0.2797 0.2797
Loa Loa (eye worm) hypothetical protein 0.0543 0.1101 0.1372
Schistosoma mansoni serine/threonine protein kinase 0.0455 0.0853 0.1848
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Schistosoma mansoni serine/threonine protein kinase 0.1118 0.2726 0.5971
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.067 0.1459 0.4598
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0259 0.0298 0.0341
Schistosoma mansoni serine/threonine protein kinase 0.0839 0.1938 0.4235
Trichomonas vaginalis STE family protein kinase 0.0302 0.0421 0.0511
Toxoplasma gondii histone kinase SNF1, putative 0.0297 0.0405 0.0506
Loa Loa (eye worm) TK protein kinase 0.0765 0.1728 0.2164
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.048 0.0923 0.1268
Entamoeba histolytica protein kinase, putative 0.0249 0.0272 0.034
Echinococcus multilocularis pdz domain containing protein 0.0164 0.0029 0.004
Echinococcus multilocularis cyclin dependent kinase 5 0.0674 0.1472 0.2022
Entamoeba histolytica protein kinase domain containing protein 0.0525 0.1051 0.1366
Leishmania major protein kinase, putative 0.0455 0.0853 0.2633
Onchocerca volvulus 0.1672 0.4291 0.8635
Brugia malayi Protein kinase domain containing protein 0.1309 0.3265 0.4102
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0735 0.1642 0.1642
Echinococcus multilocularis protein kinase shaggy 0.054 0.1092 0.15
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0337 0.052 0.0715
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.1071 0.2592 0.3561
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0337 0.052 0.0715
Loa Loa (eye worm) AGC/NDR protein kinase 0.1211 0.2987 0.3752
Giardia lamblia Kinase, CK1 Casein kinase 0.037 0.0612 0.1376
Schistosoma mansoni serine/threonine protein kinase 0.126 0.3126 0.6851
Echinococcus multilocularis casein kinase i 0.037 0.0612 0.0841
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0525 0.1051 0.3274
Echinococcus multilocularis dual specificity 0.0525 0.1051 0.1443
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0404 0.0708 0.2162
Echinococcus multilocularis dual specificity 0.0347 0.0548 0.0753
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0404 0.0708 0.1477
Schistosoma mansoni protein kinase 0.1143 0.2797 0.6127
Brugia malayi Variant SH3 domain containing protein 0.0276 0.0348 0.0422
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0297 0.0405 0.0808
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.031 0.0442 0.054
Trichomonas vaginalis CK1 family protein kinase 0.037 0.0612 0.0763
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0259 0.0298 0.0571
Entamoeba histolytica protein kinase, putative 0.0547 0.1112 0.1447
Echinococcus multilocularis serine:threonine protein kinase 0.0384 0.0653 0.0897
Schistosoma mansoni tyrosine kinase 0.1008 0.2414 0.5284
Brugia malayi Protein kinase domain containing protein 0.1221 0.3016 0.3789
Brugia malayi Protein kinase domain containing protein 0.0247 0.0265 0.0317
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0246 0.0261 0.0261
Echinococcus granulosus neuroglian 0.0397 0.0688 0.0688
Onchocerca volvulus Serine\/threonine kinase homolog 0.0871 0.2027 0.4065
Onchocerca volvulus 0.0305 0.0429 0.084
Trypanosoma brucei rac serine-threonine kinase, putative 0.2846 0.7606 1
Loa Loa (eye worm) TK/FER protein kinase 0.0305 0.0429 0.0525
Loa Loa (eye worm) hypothetical protein 0.0318 0.0466 0.0571
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0337 0.052 0.0715
Schistosoma mansoni serine/threonine kinase 0.0581 0.1209 0.2631
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0338 0.0523 0.067
Onchocerca volvulus 0.0305 0.0429 0.084
Echinococcus granulosus tyrosine protein kinase Fyn 0.0763 0.1722 0.1722
Loa Loa (eye worm) hypothetical protein 0.0192 0.0109 0.0121
Schistosoma mansoni ephrin receptor 0.0186 0.0093 0.0174
Trypanosoma cruzi NIMA-related kinase, putative 0.0259 0.0298 0.0571
Loa Loa (eye worm) CAMK/CAMKL/PASK protein kinase 0.0178 0.0069 0.0071
Leishmania major protein kinase, putative 0.0259 0.0298 0.0836
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0306 0.0431 0.0939
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.126 0.3126 0.4079
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0658 0.1425 0.1958
Echinococcus granulosus suppressor of cytokine signaling 6 0.0158 0.0013 0.0013
Entamoeba histolytica protein kinase, putative 0.2718 0.7246 0.9526
Giardia lamblia Kinase, CMGC CLK 0.0455 0.0853 0.1955
Schistosoma mansoni serine/threonine protein kinase 0.0404 0.0708 0.1528
Trichomonas vaginalis STE family protein kinase 0.0453 0.0847 0.1073
Leishmania major casein kinase, putative 0.037 0.0612 0.1853
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0978 0.2329 0.2921
Echinococcus multilocularis calcium activated potassium channel 0.0405 0.0711 0.0976
Loa Loa (eye worm) hypothetical protein 0.0273 0.034 0.0412
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0297 0.0405 0.0557
Loa Loa (eye worm) hypothetical protein 0.0337 0.052 0.064
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0455 0.0853 0.1799
Giardia lamblia Kinase, CMGC GSK 0.054 0.1092 0.253
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.112 0.2732 0.3752
Schistosoma mansoni serine/threonine protein kinase 0.0847 0.1961 0.4286
Brugia malayi Protein kinase domain containing protein 0.0674 0.1472 0.184
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0299 0.0411 0.0564
Brugia malayi hypothetical protein 0.0357 0.0575 0.0709
Giardia lamblia Kinase, STE STE20 0.0302 0.0421 0.0915
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0763 0.1722 0.2365
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Loa Loa (eye worm) hypothetical protein 0.0357 0.0575 0.0709
Entamoeba histolytica protein kinase, putative 0.0525 0.1051 0.1366
Loa Loa (eye worm) CMGC/GSK protein kinase 0.054 0.1092 0.1361
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0708 0.1567 0.196
Schistosoma mansoni serine/threonine protein kinase 0.0405 0.0711 0.1535
Trichomonas vaginalis CAMK family protein kinase 0.0422 0.0761 0.0959
Onchocerca volvulus 0.0199 0.0131 0.0237
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0337 0.052 0.1155
Trichomonas vaginalis CMGC family protein kinase 0.0674 0.1472 0.1899
Echinococcus multilocularis insulin receptor 0.1309 0.3265 0.4485
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0445 0.0825 0.1024
Entamoeba histolytica protein kinase, putative 0.0547 0.1112 0.1447
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0337 0.052 0.064
Loa Loa (eye worm) variant SH3 domain-containing protein 0.03 0.0415 0.0506
Trichomonas vaginalis CMGC family protein kinase 0.054 0.1092 0.1397
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0572 0.1183 0.1476
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0674 0.1472 0.464
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0297 0.0405 0.1182
Plasmodium falciparum protein kinase, putative 0.0279 0.0354 0.0755
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.03 0.0416 0.0504
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0326 0.0489 0.0672
Echinococcus granulosus roundabout 2 0.0178 0.0071 0.0071
Trichomonas vaginalis CMGC family protein kinase 0.0347 0.0548 0.0679
Schistosoma mansoni protein kinase 0.037 0.0612 0.1318
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0297 0.0405 0.0557
Brugia malayi Casein kinase II, alpha chain 0.0777 0.1762 0.2207
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0763 0.1722 0.2365
Entamoeba histolytica protein kinase domain containing protein 0.0777 0.1762 0.2304
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.037 0.0612 0.0756
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0249 0.0272 0.0272
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0279 0.0354 0.0695
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0674 0.1472 0.184
Loa Loa (eye worm) AUR protein kinase 0.0547 0.1112 0.1386
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0226 0.0205 0.0282
Brugia malayi ribosomal protein S6 kinase alpha 3 0.049 0.0952 0.1184
Loa Loa (eye worm) hypothetical protein 0.0482 0.093 0.1156
Entamoeba histolytica protein kinase , putative 0.0547 0.1112 0.1447
Entamoeba histolytica hypothetical protein 0.0259 0.0298 0.0375
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Echinococcus granulosus dual specificity 0.0347 0.0548 0.0548
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0455 0.0853 0.1074
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0404 0.0708 0.0876
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.0405 0.0862
Schistosoma mansoni vesicular amine transporter 0.0318 0.0466 0.0996
Brugia malayi diacylglycerol kinase 0.0192 0.0109 0.0121
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.1211 0.2987 0.4103
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0158 0.0013 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0299 0.0411 0.0497
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.081 0.1856 0.3719
Trichomonas vaginalis AGC family protein kinase 0.126 0.3126 0.4084
Entamoeba histolytica protein kinase domain containing protein 0.0547 0.1112 0.1447
Entamoeba histolytica PH domain containing protein kinase, putative 0.1387 0.3486 0.4574
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.126 0.3126 0.6832
Trichomonas vaginalis CAMK family protein kinase 0.0422 0.0761 0.0959
Onchocerca volvulus 0.1686 0.4329 0.8713
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0674 0.1472 0.464
Onchocerca volvulus 0.0326 0.0489 0.096
Brugia malayi SH2 domain containing protein 0.0305 0.0429 0.0525
Schistosoma mansoni serine/threonine protein kinase 0.0199 0.0129 0.0255
Brugia malayi Immunoglobulin I-set domain containing protein 0.0178 0.0071 0.0072
Giardia lamblia Kinase, CMGC CDK 0.0674 0.1472 0.3444
Brugia malayi Protein kinase domain containing protein 0.0694 0.1527 0.191
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0158 0.0013 0.0018
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0618 0.1312 0.4121
Echinococcus granulosus RNA directed DNA polymerase 0.0291 0.0388 0.0388
Brugia malayi Protein kinase domain containing protein 0.0305 0.0429 0.0525
Loa Loa (eye worm) hypothetical protein 0.0165 0.0034 0.0026
Echinococcus granulosus hypothetical protein 0.0158 0.0013 0.0013
Echinococcus granulosus NDR protein kinase 0.1211 0.2987 0.2987
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0455 0.0853 0.1799
Brugia malayi Sex muscle abnormal protein 5 0.0276 0.0348 0.0422
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1166 0.2859 0.3928
Brugia malayi Protein kinase domain containing protein 0.0525 0.1051 0.1309
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.067 0.1459 0.1875
Brugia malayi Protein kinase domain containing protein 0.0635 0.1362 0.1702
Loa Loa (eye worm) TK/ABL protein kinase 0.0966 0.2297 0.2881
Entamoeba histolytica casein kinase, putative 0.0777 0.1762 0.2304
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0283 0.0365 0.0502
Leishmania major protein kinase, putative 0.0547 0.1112 0.3472
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0178 0.0071 0.0126
Trichomonas vaginalis CMGC family protein kinase 0.0347 0.0548 0.0679
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0158 0.0013 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Loa Loa (eye worm) TK/FER protein kinase 0.0305 0.0429 0.0525
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.054 0.1092 0.2374
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0246 0.0261 0.0359
Echinococcus granulosus activated cdc42 kinase 1 0.0338 0.0523 0.0523
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1257 0.3118 0.4283
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.126 0.3126 0.4294
Plasmodium falciparum glycogen synthase kinase 3 0.054 0.1092 0.253
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0158 0.0013 0.0013
Echinococcus granulosus glycogen synthase kinase 3 beta 0.054 0.1092 0.1092
Brugia malayi Protein kinase domain containing protein 0.0978 0.2329 0.2921
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.021 0.0162 0.0187
Brugia malayi Protein kinase domain containing protein 0.1211 0.2987 0.3752
Schistosoma mansoni serine/threonine protein kinase 0.021 0.0162 0.0327
Trypanosoma brucei aurora B kinase 0.0547 0.1112 0.1416
Brugia malayi Protein kinase domain containing protein 0.0455 0.0853 0.1059
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0457 0.0858 0.1065
Brugia malayi cyclin-dependent kinase 7 homolog 0.022 0.0188 0.022
Echinococcus granulosus serine:threonine kinase SAD 1 0.0297 0.0405 0.0405
Schistosoma mansoni serine/threonine protein kinase 0.0658 0.1425 0.3107
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.0227 0.0469
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.004 0.0059
Echinococcus granulosus protein kinase shaggy 0.054 0.1092 0.1092
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0404 0.0708 0.1477
Schistosoma mansoni rac gtpase activating protein 0.0192 0.0109 0.0211
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0192 0.0109 0.0121
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0398 0.0693 0.0857
Brugia malayi Protein kinase domain containing protein 0.019 0.0105 0.0115
Loa Loa (eye worm) hypothetical protein 0.0384 0.0653 0.0806
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0318 0.0466 0.0996
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Echinococcus multilocularis calcium dependent protein kinase 0.0206 0.0149 0.0205
Brugia malayi hypothetical protein 0.0305 0.0429 0.0525
Trichomonas vaginalis AGC family protein kinase 0.0547 0.1112 0.1423
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0259 0.0298 0.0571
Schistosoma mansoni protein kinase C mu 0.0773 0.175 0.3822
Schistosoma mansoni tyrosine kinase 0.0424 0.0764 0.1651
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0338 0.0523 0.0718
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0199 0.0129 0.0129
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.126 0.3126 0.4294
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0326 0.0489 0.0994
Schistosoma mansoni protein kinase 0.1143 0.2797 0.6127
Schistosoma mansoni diacylglycerol kinase theta 0.0192 0.0109 0.0211
Loa Loa (eye worm) hypothetical protein 0.0776 0.1758 0.2202
Echinococcus multilocularis signal transduction protein lnk realted 0.0158 0.0013 0.0018
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.0173 0.0056 0.0029
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0404 0.0708 0.1477
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.054 0.1092 0.3408
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0259 0.0298 0.0571
Echinococcus granulosus cyclin dependent kinase 5 0.0674 0.1472 0.1472
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0318 0.0466 0.064
Trypanosoma brucei protein kinase, putative 0.0279 0.0354 0.0415
Echinococcus granulosus tyrosine protein kinase Srms 0.1135 0.2774 0.2774
Echinococcus granulosus dual specificity 0.0347 0.0548 0.0548
Echinococcus multilocularis SH2 motif 0.0158 0.0013 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.0405 0.0862
Echinococcus multilocularis Immunoglobulin 0.0318 0.0466 0.064
Echinococcus multilocularis roundabout 2 0.0496 0.0969 0.1332
Schistosoma mansoni cell adhesion molecule 0.0418 0.0748 0.1616
Loa Loa (eye worm) thyroid receptor interactor 0.0355 0.0571 0.0704
Entamoeba histolytica protein kinase 2, putative 0.1639 0.4197 0.551
Schistosoma mansoni serine/threonine protein kinase 0.157 0.4001 0.8776
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.054 0.1092 0.1459
Echinococcus multilocularis Protein kinase C, brain isozyme 0.1708 0.4391 0.6031
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0249 0.0272 0.0272
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.126 0.3126 0.6832
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0202 0.0137 0.0156
Loa Loa (eye worm) hypothetical protein 0.0458 0.086 0.1068
Brugia malayi putative serine/threonine kinase SADA gamma 0.0297 0.0405 0.0494
Echinococcus granulosus roundabout 2 0.0496 0.0969 0.0969
Schistosoma mansoni protein kinase 0.023 0.0217 0.0448
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.1508 0.3826 0.5256
Echinococcus granulosus cyclin dependent kinase 1 0.0674 0.1472 0.1472
Schistosoma mansoni serine/threonine protein kinase 0.081 0.1856 0.4054
Schistosoma mansoni tyrosine kinase 0.0582 0.1211 0.2637
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0424 0.0764 0.1651
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0772 0.1748 0.2402
Schistosoma mansoni serine/threonine protein kinase 0.126 0.3126 0.6851
Echinococcus granulosus nervana 2 0.1508 0.3826 0.3826
Loa Loa (eye worm) hypothetical protein 0.0291 0.0388 0.0473
Brugia malayi Fes/CIP4 homology domain containing protein 0.0355 0.0571 0.0704
Echinococcus multilocularis growth factor receptor bound protein 2 0.0276 0.0348 0.0477
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0178 0.0071 0.0097
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0187 0.0095 0.0103
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.0173 0.0056 0.0029
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0347 0.0548 0.0671
Schistosoma mansoni growth factor receptor-bound protein 0.0276 0.0348 0.0735
Schistosoma mansoni serine/threonine protein kinase 0.0455 0.0853 0.1848
Echinococcus granulosus Protein kinase C brain isozyme 0.1708 0.4391 0.4391
Schistosoma mansoni cell adhesion molecule 0.0178 0.0071 0.0126
Echinococcus multilocularis expressed conserved protein 0.0338 0.0523 0.0718
Trichomonas vaginalis AGC family protein kinase 0.1252 0.3105 0.4055
Schistosoma mansoni serine/threonine protein kinase 0.0338 0.0523 0.1121
Brugia malayi Immunoglobulin I-set domain containing protein 0.0851 0.197 0.2469
Loa Loa (eye worm) hypothetical protein 0.0165 0.0034 0.0026
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0337 0.052 0.064
Giardia lamblia Kinase, STE STE20 0.0292 0.0393 0.0849
Toxoplasma gondii AGC kinase 0.2718 0.7246 1
Echinococcus granulosus Glutaredoxin protein 5 0.1508 0.3826 0.3826
Plasmodium vivax serine/threonine kinase-1, putative 0.0455 0.0853 0.1955
Echinococcus granulosus raf serine:threonine protein kinase 0.0339 0.0525 0.0525
Entamoeba histolytica tyrosin kinase, putative 0.0162 0.0024 0.0014
Echinococcus granulosus casein kinase i 0.037 0.0612 0.0612
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0283 0.0365 0.0444
Loa Loa (eye worm) TK/INSR protein kinase 0.1309 0.3265 0.4102
Trypanosoma cruzi polo-like protein kinase, putative 0.0871 0.2027 0.4399
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.02 0.0131 0.0181
Brugia malayi Serine/threonine-protein kinase SULU 0.0735 0.1642 0.2055
Echinococcus multilocularis c src tyrosine kinase 0.0424 0.0764 0.1049
Giardia lamblia Kinase, AGC PKA 0.1639 0.4197 1
Echinococcus multilocularis cyclin dependent kinase 9 0.0192 0.0111 0.0152
Trichomonas vaginalis STE family protein kinase 0.0297 0.0405 0.049
Brugia malayi intracellular kinase 0.054 0.1092 0.1361
Loa Loa (eye worm) hypothetical protein 0.0338 0.0523 0.0643
Brugia malayi Temporarily assigned gene name protein 59 0.0402 0.0703 0.087
Brugia malayi bone morphogenetic protein type 1 receptor 0.023 0.0217 0.0257
Schistosoma mansoni serine/threonine protein kinase 0.1211 0.2987 0.6545
Echinococcus granulosus serine:threonine protein kinase N2 0.1624 0.4154 0.4154
Loa Loa (eye worm) hypothetical protein 0.0458 0.086 0.1068
Echinococcus granulosus cGMP dependent protein kinase 0.0338 0.0523 0.0523
Schistosoma mansoni vav2 0.0477 0.0915 0.1985
Brugia malayi Protein kinase domain containing protein 0.1286 0.32 0.402
Echinococcus granulosus TGF beta receptor type 1 0.0214 0.0172 0.0172
Loa Loa (eye worm) SRC-1 0.0763 0.1722 0.2155
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Echinococcus multilocularis dual specificity mitogen activated protein 0.0302 0.0421 0.0578
Echinococcus multilocularis cyclin dependent kinase 1 0.0674 0.1472 0.2022
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0455 0.0853 0.1074
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.081 0.1856 0.1856
Trichomonas vaginalis AGC family protein kinase 0.2846 0.7606 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0503 0.0988 0.1357
Schistosoma mansoni serine/threonine protein kinase 0.0247 0.0265 0.0554
Echinococcus granulosus dual specificity mitogen activated protein 0.0302 0.0421 0.0421
Schistosoma mansoni vam6/vps39 related 0.0326 0.0489 0.1047
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.048 0.0923 0.0923
Echinococcus granulosus mitogen activated protein kinase 14 0.067 0.1459 0.1459
Loa Loa (eye worm) hypothetical protein 0.126 0.3126 0.3927
Schistosoma mansoni serine/threonine protein kinase 0.0337 0.052 0.1116
Brugia malayi p70 ribosomal S6 kinase beta 0.2718 0.7246 0.9125
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.004 0.0008
Plasmodium vivax unspecified product 0.0777 0.1762 0.4143
Brugia malayi serine/threonine-protein kinase 6 0.0547 0.1112 0.1386
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.126 0.3126 0.7424
Echinococcus multilocularis TGF beta receptor type 1 0.0214 0.0172 0.0236
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0525 0.1051 0.1309
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.004 0.0008
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.1639 0.4197 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0229 0.0215 0.0242
Echinococcus multilocularis myotubularin protein 13 0.0319 0.0469 0.0645
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1348 0.3374 0.3374
Trichomonas vaginalis AGC family protein kinase 0.2846 0.7606 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0871 0.2027 0.4399
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0199 0.0129 0.0125
Entamoeba histolytica hypothetical protein 0.0259 0.0298 0.0375
Trichomonas vaginalis CAMK family protein kinase 0.0871 0.2027 0.2632
Onchocerca volvulus 0.037 0.0612 0.1209
Plasmodium falciparum calcium-dependent protein kinase 2 0.0337 0.052 0.1155
Trichomonas vaginalis CMGC family protein kinase 0.0347 0.0548 0.0679
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.03 0.0416 0.0504
Schistosoma mansoni ephrin receptor 0.0347 0.0547 0.1174
Trichomonas vaginalis AGC family protein kinase 0.0547 0.1112 0.1423
Brugia malayi ephrin receptor 1 precursor 0.0241 0.0249 0.0297
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0658 0.1425 0.1958
Echinococcus granulosus nervana 2 0.1508 0.3826 0.3826
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0178 0.0071 0.0097
Echinococcus multilocularis tyrosine kinase 0.0305 0.0429 0.059
Echinococcus granulosus STE20 serine:threonine protein kinase 0.1071 0.2592 0.2592
Echinococcus multilocularis serine:threonine protein kinase N2 0.1624 0.4154 0.5707
Echinococcus multilocularis casein kinase I delta 0.037 0.0612 0.0841
Entamoeba histolytica PH domain containing protein kinase, putative 0.1387 0.3486 0.4574
Trypanosoma cruzi casein kinase, putative 0.037 0.0612 0.1266
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0763 0.1722 0.2365
Brugia malayi serine/threonine-protein kinase PAK 7 0.0752 0.1691 0.2117
Onchocerca volvulus 0.0305 0.0429 0.084
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Trichomonas vaginalis CAMK family protein kinase 0.0384 0.0653 0.0817
Echinococcus multilocularis protein tyrosine kinase 0.1469 0.3717 0.5106
Entamoeba histolytica protein kinase, putative 0.0297 0.0405 0.0516
Echinococcus granulosus Vam6:Vps39 protein 0.0326 0.0489 0.0489
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.1143 0.2797 0.3842
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.004 0.0008
Brugia malayi diacylglycerol kinase 0.0192 0.0109 0.0121
Brugia malayi serine/threonine kinase 12 0.0547 0.1112 0.1386
Entamoeba histolytica protein kinase, putative 0.0233 0.0227 0.0281
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0763 0.1722 0.2365
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0337 0.052 0.052
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Schistosoma mansoni unc-13 (munc13) 0.0208 0.0156 0.0314
Schistosoma mansoni serine/threonine protein kinase 0.0183 0.0085 0.0158
Schistosoma mansoni protein kinase C mu 0.0192 0.0109 0.0211
Echinococcus multilocularis roundabout 2 0.0178 0.0071 0.0097
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0923 0.2174 0.2987
Brugia malayi Immunoglobulin I-set domain containing protein 0.0357 0.0575 0.0709
Brugia malayi Protein kinase domain containing protein 0.06 0.1261 0.1575
Echinococcus granulosus expressed conserved protein 0.0158 0.0013 0.0013
Echinococcus granulosus cyclin dependent kinase 7 0.021 0.0162 0.0162
Schistosoma mansoni nephrin 0.0435 0.0797 0.1724
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0455 0.0853 0.1128
Entamoeba histolytica protein kinase, putative 0.2846 0.7606 1
Brugia malayi RhoGAP domain containing protein 0.035 0.0555 0.0684
Schistosoma mansoni serine/threonine protein kinase 0.0347 0.0548 0.1177
Plasmodium vivax protein kinase, putative 0.0183 0.0085 0.0108
Onchocerca volvulus 0.0305 0.0429 0.084
Echinococcus multilocularis epidermal growth factor receptor 0.1091 0.265 0.364
Toxoplasma gondii AGC kinase 0.126 0.3126 0.4283
Echinococcus granulosus casein kinase I alpha 0.037 0.0612 0.0612
Schistosoma mansoni serine/threonine protein kinase 0.1708 0.4391 0.9634
Trichomonas vaginalis CMGC family protein kinase 0.0777 0.1762 0.2283
Trichomonas vaginalis AGC family protein kinase 0.0547 0.1112 0.1423
Brugia malayi Immunoglobulin I-set domain containing protein 0.2212 0.5816 0.7321
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0264 0.0314 0.038
Echinococcus granulosus N chimaerin 0.035 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0983 0.2344 0.2941
Schistosoma mansoni serine/threonine protein kinase 0.126 0.3126 0.6851
Trichomonas vaginalis CAMK family protein kinase 0.0871 0.2027 0.2632
Schistosoma mansoni protein kinase 0.0214 0.0172 0.0348
Echinococcus granulosus casein kinase I gamma 0.0498 0.0975 0.0975
Trypanosoma brucei protein kinase, putative 0.0259 0.0298 0.0341
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.067 0.1459 0.3141
Trypanosoma cruzi cdc2-related kinase 1 0.0674 0.1472 0.317
Entamoeba histolytica protein kinase, putative 0.0259 0.0298 0.0375
Echinococcus multilocularis neuroglian 0.0178 0.0071 0.0097
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0674 0.1472 0.184
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.0173 0.0056 0.0029
Entamoeba histolytica diacylglycerol kinase, putative 0.0192 0.0109 0.0126
Trypanosoma cruzi aurora B kinase, putative 0.0547 0.1112 0.2372
Echinococcus granulosus NCK adaptor protein 0.0276 0.0348 0.0348
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0158 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0206 0.0151 0.0173
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.035 0.0555 0.1193
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Brugia malayi Hr1 repeat family protein 0.1624 0.4154 0.5225
Schistosoma mansoni tyrosine kinase 0.0763 0.1722 0.3759
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Brugia malayi SH2 domain containing protein 0.0923 0.2174 0.2727
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.126 0.3126 0.3126
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Schistosoma mansoni serine/threonine protein kinase 0.0249 0.0272 0.0569
Schistosoma mansoni serine/threonine protein kinase 0.0658 0.1425 0.3107
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.1764 0.4549 0.5723
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0297 0.0405 0.0482
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0297 0.0405 0.0405
Echinococcus granulosus casein kinase I alpha 0.037 0.0612 0.0612
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0292 0.0393 0.05
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0178 0.0071 0.0072
Loa Loa (eye worm) AGC/PKA protein kinase 0.126 0.3126 0.3927
Schistosoma mansoni kinase 0.0928 0.2189 0.4789
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0214 0.0172 0.0236
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0276 0.0348 0.0422
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0305 0.0429 0.0548
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0347 0.0548 0.0675
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0297 0.0405 0.0808
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0654 0.1415 0.1944
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0763 0.1722 0.1722
Echinococcus granulosus hypothetical protein 0.0324 0.0482 0.0482
Trichomonas vaginalis AGC family protein kinase 0.0259 0.0298 0.0349
Echinococcus multilocularis casein kinase I delta 0.037 0.0612 0.0841
Plasmodium falciparum casein kinase 1 0.037 0.0612 0.1376
Onchocerca volvulus 0.0305 0.0429 0.084
Echinococcus granulosus tyrosine protein kinase Src42A 0.0763 0.1722 0.1722
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0455 0.0853 0.1059
Loa Loa (eye worm) hypothetical protein 0.0776 0.1758 0.2202
Entamoeba histolytica protein kinase domain containing protein 0.054 0.1092 0.1421
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0297 0.0405 0.0405
Schistosoma mansoni titin 0.0248 0.0269 0.0563
Schistosoma mansoni protein kinase 0.0297 0.0405 0.0862
Echinococcus granulosus serine:threonine protein kinase 0.0384 0.0653 0.0653
Echinococcus granulosus neuroglian 0.0178 0.0071 0.0071
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0458 0.086 0.086
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0763 0.1722 0.2365
Plasmodium falciparum calcium-dependent protein kinase 5 0.0337 0.052 0.1155
Echinococcus multilocularis roundabout 2 0.0178 0.0071 0.0097
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0233 0.0227 0.0259
Echinococcus multilocularis SH2 domain containing protein 7 0.0158 0.0013 0.0018
Echinococcus multilocularis mitogen activated protein kinase 14 0.067 0.1459 0.2004
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0192 0.0109 0.0121
Leishmania major protein kinase, putative 0.0337 0.052 0.1555
Entamoeba histolytica cell division protein kinase 2, putative 0.0674 0.1472 0.1921
Brugia malayi casein kinase I 0.037 0.0612 0.0756
Brugia malayi Protein kinase domain containing protein 0.2846 0.7606 0.9579
Echinococcus granulosus titin 0.0248 0.0269 0.0269
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0379 0.0638 0.0638
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0337 0.052 0.1155
Echinococcus granulosus contactin 0.0178 0.0071 0.0071
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0178 0.0071 0.0097
Schistosoma mansoni neuroglian 0.0178 0.0071 0.0126
Trypanosoma cruzi rac serine-threonine kinase, putative 0.1766 0.4557 1
Loa Loa (eye worm) hypothetical protein 0.0192 0.0109 0.0121
Schistosoma mansoni protein kinase C 0.0206 0.0151 0.0302
Leishmania major serine/threonine-protein kinase a, putative 0.0259 0.0298 0.0836
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.1639 0.4197 1
Echinococcus granulosus SH2 domain containing protein 7 0.0158 0.0013 0.0013
Leishmania major folate/biopterin transporter, putative 0.0259 0.0298 0.0836
Trichomonas vaginalis AGC family protein kinase 0.0259 0.0298 0.0349
Echinococcus granulosus serine:threonine protein kinase N2 0.0413 0.0735 0.0735
Trichomonas vaginalis CMGC family protein kinase 0.0674 0.1472 0.1899
Entamoeba histolytica protein kinase domain containing protein 0.0162 0.0024 0.0014
Echinococcus granulosus aurora kinase A 0.0547 0.1112 0.1112
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.1211 0.2987 0.2987
Toxoplasma gondii CMGC kinase, CK2 family 0.0777 0.1762 0.239
Schistosoma mansoni serine/threonine protein kinase 0.0674 0.1472 0.3211
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0249 0.0272 0.0373
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.023 0.0217 0.0257
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.1211 0.2987 0.2987
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0292 0.0393 0.0466
Echinococcus multilocularis protein kinase c eta type 0.0192 0.0109 0.015
Brugia malayi Protein kinase domain containing protein 0.0202 0.0137 0.0156
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0773 0.175 0.2191
Plasmodium falciparum calcium-dependent protein kinase 7 0.0259 0.0298 0.062
Brugia malayi Cam kinase protein 1 0.0337 0.052 0.064
Schistosoma mansoni serine/threonine protein kinase 0.037 0.0612 0.1318
Echinococcus granulosus rho-associated protein kinase 1 0.1042 0.251 0.251
Onchocerca volvulus 0.054 0.1092 0.2177
Trichomonas vaginalis AGC family protein kinase 0.0453 0.0847 0.1073
Brugia malayi Protein kinase domain containing protein 0.0572 0.1183 0.1476
Brugia malayi serine/threonine protein kinase 6 0.0547 0.1112 0.1386
Echinococcus granulosus dual specificity 0.0525 0.1051 0.1051
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0338 0.0523 0.0718
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Trypanosoma cruzi cdc2-related kinase 3 0.0674 0.1472 0.317
Echinococcus multilocularis Diacylglycerol kinase theta 0.0192 0.0109 0.015
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0291 0.0388 0.0533
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.0356 0.0754
Brugia malayi Protein kinase domain containing protein 0.0305 0.0429 0.0525
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0337 0.052 0.0634
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.126 0.3126 0.4283
Echinococcus granulosus tyrosine kinase 0.0305 0.0429 0.0429
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0276 0.0348 0.0735
Loa Loa (eye worm) AGC/PKA protein kinase 0.126 0.3126 0.3927
Trichomonas vaginalis CK1 family protein kinase 0.037 0.0612 0.0763
Trypanosoma brucei protein kinase, putative 0.0413 0.0733 0.0916
Entamoeba histolytica protein kinase, putative 0.0357 0.0574 0.0739
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.2718 0.7246 0.9125
Trypanosoma cruzi p21-activated kinase 3, putative 0.0199 0.0129 0.0196
Brugia malayi Protein kinase domain containing protein 0.0305 0.0429 0.0525
Leishmania major protein kinase, putative 0.0292 0.0393 0.1144
Onchocerca volvulus 0.0305 0.0429 0.084
Brugia malayi Tyrosine-protein kinase abl-1 0.0676 0.1478 0.1847
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0239 0.0241 0.0445
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0525 0.1051 0.2237
Brugia malayi Serine/threonine-protein kinase Pim-3 0.081 0.1856 0.2324
Giardia lamblia Kinase, NEK 0.0453 0.0847 0.1939
Echinococcus granulosus tyrosine protein kinase Btk29A 0.112 0.2732 0.2732
Trichomonas vaginalis CAMK family protein kinase 0.0572 0.1183 0.1517
Echinococcus multilocularis casein kinase I alpha 0.037 0.0612 0.0841
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Trichomonas vaginalis CMGC family protein kinase 0.0404 0.0708 0.0889
Toxoplasma gondii protein kinase domain-containing protein 0.0259 0.0298 0.0358
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2964 0.7939 1
Loa Loa (eye worm) hypothetical protein 0.0769 0.1739 0.2177
Entamoeba histolytica protein kinase, putative 0.0486 0.0941 0.1222
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Onchocerca volvulus 0.0239 0.0241 0.046
Entamoeba histolytica cell division protein kinase 2, putative 0.0683 0.1498 0.1955
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0525 0.1051 0.2237
Entamoeba histolytica casein kinase 1, putative 0.037 0.0612 0.0789
Schistosoma mansoni serine/threonine protein kinase 0.1211 0.2987 0.6545
Onchocerca volvulus 0.0206 0.0151 0.0277
Plasmodium falciparum serine/threonine protein kinase KIN 0.0297 0.0405 0.0878
Trichomonas vaginalis CAMK family protein kinase 0.0871 0.2027 0.2632
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.037 0.0612 0.0756
Brugia malayi hypothetical protein 0.0165 0.0034 0.0026
Trichomonas vaginalis CMGC family protein kinase 0.0777 0.1762 0.2283
Echinococcus granulosus signal transduction protein lnk realted 0.0158 0.0013 0.0013
Entamoeba histolytica p21-activated kinase 0.0424 0.0765 0.099
Echinococcus granulosus tensin 0.0158 0.0013 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Mycobacterium ulcerans hypothetical protein 0.0207 0.0152 0.5
Trichomonas vaginalis STE family protein kinase 0.0297 0.0405 0.049
Giardia lamblia Kinase, CMGC MAPK 0.0404 0.0708 0.1605
Entamoeba histolytica hypothetical protein 0.0246 0.0261 0.0327
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0547 0.1112 0.1447
Echinococcus multilocularis tyrosine protein kinase HCK 0.0486 0.0941 0.1293
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0674 0.1472 0.184
Plasmodium falciparum serine/threonine protein kinase 0.0233 0.0227 0.0448
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0264 0.0314 0.0432
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0276 0.0348 0.0422
Echinococcus multilocularis casein kinase I alpha 0.037 0.0612 0.0841
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0279 0.0354 0.0695
Giardia lamblia Kinase, NEK 0.0453 0.0847 0.1939
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0871 0.2027 0.2027
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Echinococcus granulosus tyrosine protein kinase HCK 0.0486 0.0941 0.0941
Echinococcus granulosus titin 0.0248 0.0269 0.0269
Entamoeba histolytica protein kinase, putative 0.054 0.1092 0.1421
Brugia malayi Protein kinase domain containing protein 0.0305 0.0429 0.0525
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.126 0.3126 0.3126
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.1286 0.32 0.402
Echinococcus granulosus serine:threonine protein kinase 0.0384 0.0653 0.0653
Plasmodium falciparum cGMP-dependent protein kinase 0.0338 0.0523 0.1161
Onchocerca volvulus 0.1042 0.251 0.504
Schistosoma mansoni serine/threonine protein kinase 0.1708 0.4391 0.9634
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0318 0.0466 0.0996
Trypanosoma brucei Casein kinase II 0.0777 0.1762 0.2276
Echinococcus granulosus serine:threonine protein kinase 3 0.0829 0.1909 0.1909
Echinococcus multilocularis cyclin dependent kinase 0.0674 0.1472 0.2022
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0398 0.0693 0.0693
Brugia malayi Kinase associated domain 1 family protein 0.0273 0.034 0.0412
Trypanosoma cruzi NIMA-related kinase, putative 0.0259 0.0298 0.0571
Echinococcus granulosus Immunoglobulin 0.0318 0.0466 0.0466
Loa Loa (eye worm) CAMK/PIM protein kinase 0.081 0.1856 0.2324
Giardia lamblia Kinase, CMGC DYRK 0.0347 0.0548 0.1221
Echinococcus granulosus tyrosine kinase 0.0644 0.1387 0.1387
Loa Loa (eye worm) AUR protein kinase 0.0547 0.1112 0.1386
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.067 0.1459 0.3141
Trypanosoma cruzi rac serine-threonine kinase, putative 0.1639 0.4197 0.9203
Brugia malayi phosphoinositide-dependent protein kinase I 0.0283 0.0365 0.0444
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Brugia malayi Immunoglobulin I-set domain containing protein 0.0178 0.0071 0.0072
Brugia malayi Variant SH3 domain containing protein 0.035 0.0555 0.0684
Echinococcus multilocularis transfer RNA-Thr 0.0338 0.0523 0.0719
Schistosoma mansoni serine/threonine kinase 0.1211 0.2987 0.6545
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0735 0.1642 0.2055
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0658 0.1425 0.1425
Brugia malayi Protein kinase domain containing protein 0.0398 0.0693 0.0857
Trypanosoma cruzi casein kinase, putative 0.037 0.0612 0.1266
Schistosoma mansoni tyrosine kinase 0.074 0.1657 0.3618
Entamoeba histolytica protein kinase, putative 0.2846 0.7606 1
Loa Loa (eye worm) TK/FER protein kinase 0.0305 0.0429 0.0525
Toxoplasma gondii AGC kinase 0.126 0.3126 0.4283
Schistosoma mansoni protein kinase 0.0763 0.1723 0.3762
Trypanosoma cruzi casein kinase, putative 0.037 0.0612 0.1266
Schistosoma mansoni serine/threonine protein kinase 0.0398 0.0693 0.1495
Schistosoma mansoni cell adhesion molecule 0.0178 0.0071 0.0126
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.1252 0.3105 0.39
Schistosoma mansoni tyrosine kinase 0.159 0.4059 0.8904
Echinococcus granulosus mitogen activated protein kinase 11 0.067 0.1459 0.1459
Loa Loa (eye worm) hypothetical protein 0.0319 0.0469 0.0575
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.126 0.3126 0.4294
Trichomonas vaginalis AGC family protein kinase 0.2846 0.7606 1
Loa Loa (eye worm) TK protein kinase 0.0851 0.197 0.2469
Plasmodium vivax calcium-dependent protein kinase, putative 0.0337 0.052 0.1155
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0455 0.0853 0.1799
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Echinococcus granulosus cGMP dependent protein kinase 1 0.0338 0.0523 0.0523
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0404 0.0708 0.0882
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0763 0.1722 0.1722
Echinococcus multilocularis Rac GTPase activating protein 1 0.0192 0.0109 0.015
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0735 0.1642 0.2256
Trichomonas vaginalis STE family protein kinase 0.0297 0.0405 0.049
Echinococcus granulosus cyclin dependent kinase 9 0.0183 0.0085 0.0085
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0398 0.0693 0.0951
Echinococcus multilocularis rho associated protein kinase 0.1042 0.251 0.3448
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.1129 0.2755 0.2755
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0708 0.1567 0.196
Echinococcus multilocularis c Jun NH2 terminal kinase 0.1118 0.2726 0.3745
Trichomonas vaginalis CMGC family protein kinase 0.0347 0.0548 0.0679
Entamoeba histolytica protein kinase, putative 0.0357 0.0574 0.0739
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0347 0.0548 0.0705
Schistosoma mansoni serine/threonine protein kinase 0.0801 0.1829 0.3996
Entamoeba histolytica hypothetical protein 0.0192 0.0109 0.0126
Entamoeba histolytica protein kinase, putative 0.0525 0.1051 0.1366
Brugia malayi Immunoglobulin I-set domain containing protein 0.0187 0.0095 0.0103
Trichomonas vaginalis CMGC family protein kinase 0.0777 0.1762 0.2283
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0229 0.0215 0.0419
Trichomonas vaginalis AGC family protein kinase 0.0292 0.0391 0.0471
Trypanosoma brucei cdc2-related kinase 1 0.0674 0.1472 0.1892
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0436 0.08 0.0993
Entamoeba histolytica protein kinase, putative 0.0337 0.052 0.0668
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0233 0.0227 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0248 0.0269 0.0563
Echinococcus granulosus c-Jun N-terminal kinases 0.1118 0.2726 0.2726
Loa Loa (eye worm) hypothetical protein 0.0192 0.0109 0.0121
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0337 0.052 0.1155
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0302 0.0421 0.0503
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Schistosoma mansoni tyrosine kinase 0.0772 0.1748 0.3819
Loa Loa (eye worm) TK/KIN16 protein kinase 0.2212 0.5816 0.7321
Leishmania major protein kinase A catalytic subunit 0.126 0.3126 1
Schistosoma mansoni serine/threonine protein kinase 0.021 0.016 0.0323
Trichomonas vaginalis STE family protein kinase 0.0292 0.0393 0.0474
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0302 0.0421 0.0514
Entamoeba histolytica hypothetical protein 0.0774 0.1753 0.2292
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0279 0.0354 0.0415
Leishmania major protein kinase A catalytic subunit isoform 2 0.126 0.3126 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0871 0.2027 0.6438
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0547 0.1112 0.2577
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0199 0.0129 0.0146
Echinococcus multilocularis casein kinase I gamma 0.0498 0.0975 0.134
Trichomonas vaginalis CMGC family protein kinase 0.0777 0.1762 0.2283
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0158 0.0013 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0158 0.0013 0.0018
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.126 0.3126 0.6832
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0347 0.0548 0.1645
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0297 0.0405 0.0405
Plasmodium falciparum serine/threonine protein kinase, putative 0.0547 0.1112 0.2577
Brugia malayi SRC-1 0.0763 0.1722 0.2155
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0337 0.052 0.0666
Plasmodium vivax protein kinase Crk2 0.0674 0.1472 0.3444
Loa Loa (eye worm) TKL/LRRK protein kinase 0.02 0.0131 0.0149
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0674 0.1472 0.1987
Brugia malayi Temporarily assigned gene name protein 59 0.0326 0.0489 0.06
Brugia malayi C1-like domain containing protein 0.0773 0.175 0.2191
Loa Loa (eye worm) hypothetical protein 0.0394 0.068 0.0841
Echinococcus granulosus dual specificity protein kinase clk2 0.0455 0.0853 0.0853
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0233 0.0227 0.0604
Schistosoma mansoni serine/threonine protein kinase 0.0547 0.1112 0.2417
Brugia malayi Protein kinase domain containing protein 0.0233 0.0227 0.0269
Echinococcus granulosus c src tyrosine kinase 0.0424 0.0764 0.0764
Schistosoma mansoni serine/threonine protein kinase 0.021 0.0162 0.0327
Brugia malayi RhoGEF domain containing protein 0.0192 0.0109 0.0121
Loa Loa (eye worm) IKK protein kinase 0.1672 0.4291 0.5397
Schistosoma mansoni serine/threonine-protein kinase 0.1766 0.4557 1
Echinococcus granulosus insulin receptor 0.1309 0.3265 0.3265
Schistosoma mansoni nck2/grb4 0.0276 0.0348 0.0735
Echinococcus granulosus casein kinase I delta 0.037 0.0612 0.0612
Giardia lamblia Kinase, CAMK CAMKL 0.0306 0.0431 0.0939
Onchocerca volvulus 0.0248 0.0269 0.0516
Loa Loa (eye worm) hypothetical protein 0.0191 0.0107 0.0118
Trichomonas vaginalis CMGC family protein kinase 0.0404 0.0708 0.0889
Entamoeba histolytica casein kinase, putative 0.037 0.0612 0.0789
Echinococcus multilocularis protein KINase family member (kin 25) 0.0221 0.0191 0.0263
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0763 0.1722 0.2365
Loa Loa (eye worm) hypothetical protein 0.0285 0.0373 0.0454
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1166 0.2859 0.2859
Schistosoma mansoni serine/threonine protein kinase 0.1035 0.2492 0.5455
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Loa Loa (eye worm) hypothetical protein 0.0319 0.047 0.0575
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.004 0.0008
Schistosoma mansoni nephrin 0.0178 0.0071 0.0126
Brugia malayi Tyrosine-protein kinase abl-1 0.0408 0.0721 0.0892
Schistosoma mansoni protein kinase 0.0777 0.1762 0.385
Schistosoma mansoni serine/threonine protein kinase 0.0735 0.1642 0.3585
Entamoeba histolytica protein kinase, putative 0.0249 0.0272 0.034
Echinococcus multilocularis activated cdc42 kinase 1 0.0338 0.0523 0.0719
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.035 0.0555 0.0763
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.035 0.0555 0.0555
Schistosoma mansoni hypothetical protein 0.0192 0.0109 0.0211
Echinococcus granulosus dual specificity 0.0347 0.0548 0.0548
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0249 0.0272 0.0373
Schistosoma mansoni tyrosine kinase 0.0245 0.0259 0.0541
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0453 0.0847 0.1939
Schistosoma mansoni serine/threonine protein kinase 0.0405 0.0711 0.1535
Trichomonas vaginalis CMGC family protein kinase 0.0674 0.1472 0.1899
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0404 0.0708 0.0926
Echinococcus granulosus Diacylglycerol kinase theta 0.0192 0.0109 0.0109
Loa Loa (eye worm) CAMK/PIM protein kinase 0.081 0.1856 0.2324
Brugia malayi hypothetical protein 0.0326 0.0489 0.06
Trichomonas vaginalis STE family protein kinase 0.0168 0.004 0.0008
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0283 0.0365 0.0365
Loa Loa (eye worm) TK protein kinase 0.0644 0.1387 0.1734
Echinococcus multilocularis serine:threonine protein kinase N2 0.0413 0.0735 0.1009
Brugia malayi cell division control protein 2 homolog 0.0674 0.1472 0.184
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0199 0.0129 0.0146
Brugia malayi probable protein kinase 0.0772 0.1747 0.2187
Loa Loa (eye worm) AUR protein kinase 0.0547 0.1112 0.1386
Trichomonas vaginalis CMGC family protein kinase 0.0247 0.0265 0.0305
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0199 0.0129 0.0146
Trypanosoma brucei casein kinase I, isoform 2 0.037 0.0612 0.0756
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0259 0.0298 0.0341
Echinococcus granulosus tyrosine protein kinase Fyn 0.0763 0.1722 0.1722
Entamoeba histolytica hypothetical protein 0.0525 0.1051 0.1366
Plasmodium vivax tyrosine kinase-like protein, putative 0.0229 0.0215 0.0419
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Trypanosoma cruzi casein kinase, putative 0.037 0.0612 0.1266
Trichomonas vaginalis AGC family protein kinase 0.03 0.0416 0.0504
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0347 0.0548 0.1124
Schistosoma mansoni serine/threonine protein kinase 0.0199 0.0129 0.0255
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.126 0.3126 0.6832
Brugia malayi Protein kinase domain containing protein 0.0282 0.0365 0.0443
Echinococcus multilocularis 0.0324 0.0482 0.0662
Onchocerca volvulus 0.0449 0.0837 0.1662
Loa Loa (eye worm) CDC7 protein kinase 0.0247 0.0265 0.0317
Echinococcus granulosus protein kinase c iota type 0.1661 0.4259 0.4259
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0326 0.0489 0.0593
Echinococcus multilocularis casein kinase ii subunit alpha 0.0777 0.1762 0.2421
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0259 0.0298 0.0571
Schistosoma mansoni hypothetical protein 0.0273 0.034 0.0718
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0644 0.1387 0.1906
Onchocerca volvulus 0.0769 0.1739 0.3483
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0801 0.1829 0.1829
Giardia lamblia Kinase, CMGC GSK 0.054 0.1092 0.253
Plasmodium falciparum calcium-dependent protein kinase 1 0.0337 0.052 0.1155
Echinococcus multilocularis tensin 0.0158 0.0013 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0363 0.0594 0.1277
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0206 0.0151 0.0151
Schistosoma mansoni hypothetical protein 0.0326 0.0489 0.1047
Loa Loa (eye worm) hypothetical protein 0.094 0.2221 0.2786
Echinococcus multilocularis ephrin type A receptor 4 A 0.0347 0.0547 0.0751
Echinococcus multilocularis tyrosine protein kinase 0.0635 0.1362 0.1871
Echinococcus granulosus expressed protein 0.0233 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0804 0.1838 0.2303
Brugia malayi MAP kinase sur-1 0.0404 0.0708 0.0876
Schistosoma mansoni serine/threonine protein kinase 0.1709 0.4396 0.9645
Loa Loa (eye worm) raf kinase 0.0192 0.0109 0.0121
Loa Loa (eye worm) hypothetical protein 0.0326 0.0489 0.06
Echinococcus granulosus SH2 domain containing adapter protein F 0.0158 0.0013 0.0013
Onchocerca volvulus Serine\/threonine kinase homolog 0.0398 0.0693 0.1371
Brugia malayi Egg laying defective protein 4 0.0338 0.0523 0.0643
Echinococcus granulosus CDC7 cell division cycle 7 0.0247 0.0265 0.0265
Giardia lamblia Kinase, STE STE20 0.0297 0.0405 0.0878
Trypanosoma cruzi cdc2-related kinase 3 0.0674 0.1472 0.317
Brugia malayi protein kinase C3,putative 0.0582 0.121 0.151
Schistosoma mansoni serine/threonine protein kinase 0.0708 0.1567 0.342
Entamoeba histolytica PH domain containing protein kinase, putative 0.0551 0.1124 0.1462
Schistosoma mansoni protein kinase 0.0229 0.0214 0.0442
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0371 0.0616 0.0761
Echinococcus multilocularis PAK box P21 Rho binding 0.0229 0.0214 0.0295
Echinococcus multilocularis 0.0445 0.0825 0.1133
Echinococcus multilocularis tyrosine protein kinase Abl 0.0676 0.1478 0.203
Loa Loa (eye worm) TK/ROR protein kinase 0.0226 0.0205 0.0242
Trichomonas vaginalis CMGC family protein kinase 0.0777 0.1762 0.2283
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.0405 0.049
Trichomonas vaginalis AGC family protein kinase 0.2846 0.7606 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.0338 0.0523 0.0523
Schistosoma mansoni protein kinase 0.0302 0.0421 0.0897
Loa Loa (eye worm) hypothetical protein 0.0394 0.068 0.0841
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0056 0.0029
Entamoeba histolytica protein kinase, putative 0.0289 0.0384 0.0489
Echinococcus granulosus tyrosine protein kinase shark 0.074 0.1657 0.1657
Loa Loa (eye worm) hypothetical protein 0.1823 0.4716 0.5933
Schistosoma mansoni serine/threonine protein kinase 0.0871 0.2027 0.4432
Schistosoma mansoni ste20-related kinase 0.0668 0.1454 0.317
Echinococcus multilocularis dual specificity 0.0347 0.0548 0.0753
Brugia malayi P38 map kinase family protein 2 0.067 0.1459 0.1824
Leishmania major protein kinase, putative 0.0455 0.0853 0.2633
Trichomonas vaginalis AGC family protein kinase 0.1252 0.3105 0.4055
Trichomonas vaginalis AGC family protein kinase 0.0259 0.0298 0.0349
Schistosoma mansoni serine/threonine protein kinase 0.0405 0.0711 0.1535
Plasmodium falciparum NIMA related kinase 1 0.0453 0.0847 0.1939
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0674 0.1472 0.1472
Echinococcus multilocularis epidermal growth factor receptor 0.159 0.4059 0.5575
Loa Loa (eye worm) hypothetical protein 0.0357 0.0575 0.0709
Echinococcus granulosus serine:threonine protein kinase N2 0.0424 0.0764 0.0764
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0752 0.1691 0.2117
Loa Loa (eye worm) hypothetical protein 0.0221 0.0191 0.0224
Echinococcus granulosus unc 13 munc13 0.0206 0.0151 0.0151
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.1121 0.2734 0.3565
Trypanosoma brucei SNF1-related protein kinases, putative 0.0297 0.0405 0.0482
Schistosoma mansoni protein kinase 0.0457 0.0858 0.1858
Echinococcus granulosus epidermal growth factor receptor 0.1091 0.265 0.265
Plasmodium falciparum calcium-dependent protein kinase 4 0.0337 0.052 0.1155
Echinococcus multilocularis cyclin dependent kinase 9 0.0183 0.0085 0.0117
Echinococcus multilocularis aurora kinase A 0.0547 0.1112 0.1527
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0763 0.1722 0.2365
Entamoeba histolytica protein kinase domain containing protein 0.0347 0.0548 0.0704
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0871 0.2027 0.2785

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.413 uM Inhibition of VEGFR2 ChEMBL. 16979339
IC50 (binding) = 0.413 uM Inhibition of VEGFR2 ChEMBL. 16979339
IC50 (functional) = 4.924 uM Antiproliferative activity against A375 cells ChEMBL. 16979339
IC50 (functional) = 4.924 uM Antiproliferative activity against A375 cells ChEMBL. 16979339
IC50 (functional) = 16.06 uM Antiproliferative activity against HCT116 cells ChEMBL. 16979339
IC50 (functional) = 16.06 uM Antiproliferative activity against HCT116 cells ChEMBL. 16979339
IC50 (functional) = 22.66 uM Antiproliferative activity against HeLa cells ChEMBL. 16979339
IC50 (functional) = 22.66 uM Antiproliferative activity against HeLa cells ChEMBL. 16979339

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16979339

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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