Detailed information for compound 549516

Basic information

Technical information
  • TDR Targets ID: 549516
  • Name: benzamidine hydrochloride
  • MW: 156.613 | Formula: C7H9ClN2
  • H donors: 1 H acceptors: 0 LogP: 1.69 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)c1ccccc1.Cl
  • InChi: 1S/C7H8N2.ClH/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H3,8,9);1H
  • InChiKey: LZCZIHQBSCVGRD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • benzenecarboximidamide hydrochloride
  • benzenecarboximidoylazanium chloride
  • benzenecarboximidoylammonium chloride
  • [imino(phenyl)methyl]ammonium chloride
  • (C-phenylcarbonimidoyl)azanium chloride
  • benzimidoylammonium chloride
  • [amino(phenyl)methylidene]azanium chloride
  • [amino(phenyl)methylene]ammonium chloride
  • [azanyl(phenyl)methylidene]azanium chloride
  • benzamidine
  • 1670-14-0
  • 143504-23-8
  • Benzamidine hydrochloride solution
  • ST001862
  • Benzamidine monohydrochloride
  • 434760_SIAL
  • EU-0100203
  • benzenecarboximidamine hydrochloride
  • Amidinobenzene hydrochloride (1:1)
  • Benzamidine, monohydrochloride
  • Benzenecarboximidamide, monohydrochloride
  • NSC2020
  • AI3-52285
  • Benzamidine, hydrochloride
  • Benzenecarboximidamide, monohydrochloride, hydrate
  • EINECS 216-795-4
  • NSC 2020
  • 63226_FLUKA
  • Additive Screening Solution 37/Fluka kit no 78374
  • Benzamidine hydrochloride 1 M solution
  • (amino-phenylmethylidene)azanium chloride
  • (amino-phenyl-methylene)ammonium chloride
  • (amino-phenylmethylene)ammonium chloride
  • (amino-phenyl-methylidene)azanium chloride
  • (imino-phenylmethyl)ammonium chloride
  • (phenylcarbonimidoyl)azanium chloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania major pyroglutamyl-peptidase I (C15 family) Curated by TDR Targets References
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei pyroglutamyl-peptidase I, putative Get druggable targets OG5_150045 All targets in OG5_150045
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi pyroglutamyl-peptidase I, putative Get druggable targets OG5_150045 All targets in OG5_150045
Leishmania major pyroglutamyl-peptidase I (C15 family) Get druggable targets OG5_150045 All targets in OG5_150045
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense pyroglutamyl-peptidase I (PGP), putative,cysteine peptidase, Clan CF, family C15, putative Get druggable targets OG5_150045 All targets in OG5_150045
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum pyroglutamyl-peptidase I (PGP), putative Get druggable targets OG5_150045 All targets in OG5_150045
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 Get druggable targets OG5_150045 All targets in OG5_150045
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana pyroglutamyl-peptidase I (PGP), putative,cysteine peptidase, Clan CF, family C15, putative Get druggable targets OG5_150045 All targets in OG5_150045
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani pyroglutamyl-peptidase I, putative Get druggable targets OG5_150045 All targets in OG5_150045
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis pyroglutamyl-peptidase I (PGP), putative Get druggable targets OG5_150045 All targets in OG5_150045
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0017 0.0175
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0048 0.0351
Trypanosoma cruzi pyroglutamyl-peptidase I, putative 0.0519 0.1042 0.7214
Schistosoma mansoni importin beta-1 0.0031 0.0034 0.0119
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0034 0.004 0.0243
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0041 0.0041
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0015 0.008
Schistosoma mansoni hypothetical protein 0.0022 0.0015 0.0054
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0052 0.0179
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0082 0.1578
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0026 0.0262
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0034 0.004 0.004
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0082 0.0625
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0381
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0015 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0166 0.0312 0.1084
Trypanosoma brucei cytochrome P450, putative 0.004 0.0052 0.0329
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0105 0.4264
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0015 0.008
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0034 0.004 0.0282
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0166 0.0312 0.3199
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0015 0.008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0015 0.0052
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0034 0.004 0.0138
Loa Loa (eye worm) hypothetical protein 0.0109 0.0194 0.1987
Schistosoma mansoni cpg binding protein 0.0084 0.0143 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0052 0.0971
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0015 0.0054
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0003 0.0034
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0341 0.0675 0.2344
Echinococcus granulosus GPCR family 2 0.0098 0.0173 0.0589
Mycobacterium leprae Probable lipase LipE 0.0109 0.0194 0.8423
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.0121 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0015 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0085
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0194 0.1353
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0048 0.0495
Schistosoma mansoni survival motor neuron protein 0.0051 0.0074 0.0257
Leishmania major hypothetical protein, conserved 0.0109 0.0194 0.1524
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0052 0.0329
Echinococcus granulosus glycoprotein Antigen 5 0.0022 0.0015 0.0053
Onchocerca volvulus 0.0022 0.0015 0.0229
Schistosoma mansoni intermediate filament proteins 0.0114 0.0205 0.0711
Echinococcus granulosus FTZ F1 alpha 0.0166 0.0312 0.1064
Schistosoma mansoni hypothetical protein 0.0034 0.004 0.0138
Loa Loa (eye worm) hypothetical protein 0.0151 0.0282 0.2886
Echinococcus multilocularis ecdysone induced protein 78C 0.0166 0.0312 0.0312
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0121 0.0811
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0052 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0194 0.1316
Echinococcus multilocularis musashi 0.0114 0.0205 0.0205
Trichomonas vaginalis DNA helicase recq1, putative 0.005 0.0072 0.1372
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0052 0.6153
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0012 0.0142
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0034 0.004 0.025
Brugia malayi Nuclear hormone receptor-like 1 0.0151 0.0282 0.2886
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0034 0.004 0.004
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0121 0.0121
Giardia lamblia Sgs1 DNA helicase, putative 0.0035 0.0041 0.4663
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0015 0.0201
Schistosoma mansoni ap endonuclease 0.0038 0.0048 0.0168
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0035 0.0041 0.2937
Mycobacterium ulcerans lipase LipD 0.0109 0.0194 0.1524
Onchocerca volvulus 0.0166 0.0312 0.4624
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0166 0.0312 0.3199
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0015 0.008
Loa Loa (eye worm) hypothetical protein 0.0341 0.0675 0.6917
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0022 0.0015 0.0053
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0017 0.1005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0036 0.0125
Schistosoma mansoni nuclear hormone receptor 0.0166 0.0312 0.1084
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0315 0.6315
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0713 0.1442 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0048 0.0887
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.0173 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0166 0.0312 0.3199
Mycobacterium tuberculosis Conserved protein 0.0109 0.0194 0.1353
Mycobacterium tuberculosis Probable reductase 0.0112 0.0202 0.1407
Mycobacterium ulcerans aldehyde dehydrogenase 0.0618 0.1246 1
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0116 0.2263
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0082 0.0844
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0166 0.0312 0.3199
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0071 0.0462
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0034 0.004 0.0282
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0015 0.008
Loa Loa (eye worm) glutathione reductase 0.0049 0.0071 0.073
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0036 0.0036
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0015 0.0069
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.0483 0.0483
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0033 0.0572
Onchocerca volvulus 0.0053 0.008 0.118
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0034 0.004 0.0282
Loa Loa (eye worm) hypothetical protein 0.004 0.0052 0.0538
Loa Loa (eye worm) hypothetical protein 0.0053 0.0079 0.0806
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0055 0.0083 0.0283
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0082 0.0625
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0048 0.0303
Schistosoma mansoni ran 0.0023 0.0017 0.0059
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0015 0.0071
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0034 0.004 0.0243
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0017 0.0666
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0017 0.0086
Mycobacterium tuberculosis Conserved protein 0.0109 0.0194 0.1353
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0227 0.1592
Onchocerca volvulus Protein ultraspiracle homolog 0.0166 0.0312 0.4624
Loa Loa (eye worm) hypothetical protein 0.0098 0.0173 0.1771
Echinococcus multilocularis 0.0022 0.0015 0.0015
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0052 0.0052
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0005 0.0016
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0048 0.3741
Echinococcus multilocularis neuropeptide s receptor 0.1434 0.2933 0.2933
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0047 0.0066 0.4949
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0166 0.0312 0.3199
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0015 0.0071
Brugia malayi Trypsin family protein 0.0341 0.0675 0.6917
Toxoplasma gondii aldehyde dehydrogenase 0.0618 0.1246 1
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0315 0.6315
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0128 0.6519
Brugia malayi Pre-SET motif family protein 0.0032 0.0036 0.0369
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0003 0.0003
Onchocerca volvulus Huntingtin homolog 0.0129 0.0236 0.3498
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0003 0.0012
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0034 0.004 0.0282
Schistosoma mansoni chromobox protein 0.0071 0.0116 0.0403
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0315 0.6315
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.0173 0.0173
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0341 0.0675 0.2344
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0034 0.004 0.0243
Schistosoma mansoni aldehyde dehydrogenase 0.0034 0.004 0.0138
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0034 0.004 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0166 0.0312 0.3199
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0015 0.0071
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0166 0.0312 0.0312
Leishmania major hypothetical protein, conserved 0.0077 0.0128 0.0993
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0048 1
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0034 0.004 0.0243
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0015 0.008
Leishmania major aldehyde dehydrogenase, putative 0.0034 0.004 0.0282
Brugia malayi Trypsin family protein 0.0022 0.0015 0.0158
Echinococcus multilocularis FTZ F1 alpha 0.0166 0.0312 0.0312
Trichomonas vaginalis helicase, putative 0.0019 0.0009 0.0085
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0082 0.054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0166 0.0312 0.1064
Echinococcus granulosus enteropeptidase 0.0022 0.0015 0.0053
Echinococcus granulosus importin subunit beta 1 0.0031 0.0034 0.0117
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0033 0.0572
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0034 0.004 0.1175
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0034 0.004 0.0407
Leishmania major cytochrome p450-like protein 0.0022 0.0015 0.008
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0034 0.0205
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0121 0.0939
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0033 0.0572
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0074 0.076
Echinococcus multilocularis cpg binding protein 0.0089 0.0153 0.0153
Onchocerca volvulus 0.0031 0.0034 0.0502
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0082 0.054
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0052 0.0971
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.035
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0034 0.0237
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0061 0.0095 0.0978
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0194 0.1987
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0034 0.004 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0166 0.0312 0.3199
Schistosoma mansoni hypothetical protein 0.0051 0.0074 0.0257
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0006 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0015 0.0054
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0048 0.2315
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.085
Brugia malayi Cytochrome P450 family protein 0.004 0.0052 0.0533
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0034 0.004 0.1175
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0005 0.0005
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0041 0.0138
Schistosoma mansoni inositol monophosphatase 0.0073 0.0121 0.0421
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0047 0.0344
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0121 0.0811
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0034 0.004 0.3014
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.0713 0.1442 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0015 0.0071
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0026 0.0087
Brugia malayi Trypsin-like protease protein 5 0.0022 0.0015 0.0158
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0033 0.0572
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0225 0.2304
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0227 0.1592
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0034 0.004 0.025
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0166 0.0312 0.1084
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0031 0.1383
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0034 0.004 0.025
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0034 0.004 0.0243
Brugia malayi Heterochromatin protein 1 0.0071 0.0116 0.1189
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0005 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0194 0.1316
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0033 0.0572
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0034 0.004 0.0711
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0015 0.008
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0082 0.054
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0015 0.0069
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0194 0.1524
Loa Loa (eye worm) hypothetical protein 0.0151 0.0282 0.2886
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0015 0.008
Loa Loa (eye worm) trypsin family protein 0.0022 0.0015 0.0158
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0022 0.0015 0.0054
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0496 1
Brugia malayi Thioredoxin reductase 0.0049 0.0071 0.073
Onchocerca volvulus Bile acid receptor homolog 0.0166 0.0312 0.4624
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0015 0.0071
Leishmania major GTP-binding protein, putative 0.0023 0.0017 0.01
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0105 0.072
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0022 0.0015 0.0015
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0128 0.0857
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0166 0.0312 0.3199
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0194 0.1353
Echinococcus multilocularis microtubule associated protein 2 0.1408 0.2879 0.2879
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0166 0.0312 0.1064
Schistosoma mansoni thyroid hormone receptor 0.0166 0.0312 0.1084
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0025 0.0255
Echinococcus multilocularis chromobox protein 1 0.0071 0.0116 0.0116
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0121 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0033 0.0572
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0015 0.0054
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0015 0.0054
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0034 0.004 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0052 0.0953
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0006 0.002
Schistosoma mansoni hypothetical protein 0.0801 0.1625 0.5644
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0015 0.0054
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0194 0.1987
Loa Loa (eye worm) hypothetical protein 0.0151 0.0282 0.2886
Echinococcus granulosus chromobox protein 1 0.0071 0.0116 0.0395
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0227 0.1592
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0151 0.0282 0.096
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0082 0.0625
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0017 0.0058
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0194 0.1316
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0017 0.0086
Loa Loa (eye worm) aldehyde dehydrogenase 0.0034 0.004 0.0407
Loa Loa (eye worm) RecQ helicase 0.005 0.0072 0.074
Mycobacterium tuberculosis Conserved protein 0.0109 0.0194 0.1353
Brugia malayi beta-lactamase family protein 0.0109 0.0194 0.1987
Brugia malayi hypothetical protein 0.0248 0.0483 0.4946
Brugia malayi Trypsin family protein 0.0022 0.0015 0.0158
Echinococcus multilocularis snurportin 1 0.0334 0.066 0.066
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0158
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0071 0.0475
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0048 0.0887
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0052 0.0182
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0158
Loa Loa (eye worm) hypothetical protein 0.0109 0.0194 0.1987
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0017 0.0017
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0048 0.0495
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0116 0.2263
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0034 0.004 0.0243
Schistosoma mansoni aldehyde dehydrogenase 0.0618 0.1246 0.4327
Echinococcus granulosus ecdysone induced protein 78C 0.0166 0.0312 0.1064
Brugia malayi Trypsin family protein 0.0022 0.0015 0.0158
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0034 0.004 0.0135
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0052 0.0381
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0015 0.0054
Schistosoma mansoni microtubule-associated protein tau 0.1408 0.2879 1
Brugia malayi MAP kinase sur-1 0.0055 0.0082 0.0844
Brugia malayi CXXC zinc finger family protein 0.0084 0.0143 0.147
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0015 0.008
Leishmania major importin beta-1 subunit, putative 0.0025 0.0022 0.0139
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0116 0.1189
Toxoplasma gondii thioredoxin reductase 0.0049 0.0071 0.0536
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0232 0.0448 0.4593
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0022 0.012
Treponema pallidum ATP-dependent DNA helicase 0.0018 0.0006 0.0267
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0151 0.0282 0.0978
Mycobacterium ulcerans hypothetical protein 0.0109 0.0194 0.1524
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0034 0.004 0.0243
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0618 0.1246 0.4248
Brugia malayi RNA, U transporter 1 0.0089 0.0154 0.1573
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0419
Schistosoma mansoni coup transcription factor 0.0166 0.0312 0.1084
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0194 1
Trichomonas vaginalis DNA helicase recq, putative 0.005 0.0072 0.1372
Brugia malayi Steroid receptor seven-up type 2 0.0166 0.0312 0.3199
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0151 0.0282 0.0282
Brugia malayi Bloom's syndrome protein homolog 0.005 0.0072 0.074
Loa Loa (eye worm) hypothetical protein 0.0077 0.0128 0.1311
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0034 0.004 0.0282
Loa Loa (eye worm) hypothetical protein 0.0112 0.02 0.2054
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0048 0.0351
Brugia malayi steroid hormone receptor 0.0166 0.0312 0.3199
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.0173 0.0589
Echinococcus granulosus cpg binding protein 0.0089 0.0153 0.0523
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0194 0.0661
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0015 0.0071
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.0407
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0015 0.005
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0166 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.0407
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0166 0.0312 0.0312
Treponema pallidum gamma-glutamyl phosphate reductase 0.0034 0.004 0.8021
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0034 0.004 0.0135
Echinococcus multilocularis GPCR, family 2 0.0098 0.0173 0.0173
Trypanosoma brucei pyroglutamyl-peptidase I, putative 0.0519 0.1042 0.7214
Echinococcus granulosus Mastin 0.0022 0.0015 0.0053
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0034 0.004 0.1175
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0032 0.0036 0.0369
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0194 0.0673
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0082 0.1578
Brugia malayi chromobox protein homolog 3 0.004 0.0052 0.0529
Onchocerca volvulus 0.0022 0.0015 0.0229
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0151 0.0282 0.2886
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0015 0.008
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0034 0.004 0.0243
Schistosoma mansoni hypothetical protein 0.0022 0.0015 0.0054
Trichomonas vaginalis esterase, putative 0.0109 0.0194 0.3847
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0034 0.004 0.025
Onchocerca volvulus 0.0084 0.0143 0.2125
Plasmodium vivax importin-beta 2, putative 0.0031 0.0034 0.1568
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0082 1
Echinococcus granulosus neuropeptide s receptor 0.1434 0.2933 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0028 0.0466
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0194 0.1353
Echinococcus multilocularis neuropeptide receptor A26 0.1434 0.2933 0.2933
Schistosoma mansoni cytochrome P450 0.0022 0.0015 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0166 0.0312 0.3199
Loa Loa (eye worm) beta-lactamase 0.0109 0.0194 0.1987
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0082 0.0281
Brugia malayi beta-lactamase 0.0109 0.0194 0.1987
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0166 0.0312 0.0312
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0015 0.0071
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0052 0.0329
Schistosoma mansoni aldehyde dehydrogenase 0.0034 0.004 0.0138
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0015 0.0071
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0034 0.004 0.0282
Loa Loa (eye worm) hypothetical protein 0.0166 0.0312 0.3199
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0029 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0158
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0694 0.1403 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0015 0.0069
Echinococcus multilocularis Mastin 0.0022 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0166 0.0312 0.3199
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0347
Mycobacterium ulcerans beta-lactamase 0.0109 0.0194 0.1524
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0034 0.004 0.0243
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0082 0.1578
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0618 0.1246 0.1246
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0082 0.1578
Mycobacterium ulcerans aldehyde dehydrogenase 0.0034 0.004 0.0282
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.0483 0.1646
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0128 0.0857
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0082 0.054
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0194 0.8423
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0034 0.004 0.025
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0202 0.1407
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0018 0.0006 0.0008
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0034 0.004 0.0243
Schistosoma mansoni hypothetical protein 0.0098 0.0173 0.06
Loa Loa (eye worm) hypothetical protein 0.0166 0.0312 0.3199
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0058 0.108
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0036 0.0125
Schistosoma mansoni DNA helicase recq5 0.0035 0.0041 0.0142
Echinococcus multilocularis transmembrane protease serine 3 0.0022 0.0015 0.0015
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0017 0.0086
Loa Loa (eye worm) hypothetical protein 0.0341 0.0675 0.6917
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0166 0.0312 0.3199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0232 0.0448 0.1556
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0015 0.0071
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0496 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0166 0.0312 0.3199
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0015 0.008
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0227 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0194 0.1353
Brugia malayi follicle stimulating hormone receptor 0.0487 0.0976 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0036 0.0252
Brugia malayi Cytochrome P450 family protein 0.0101 0.0177 0.1817
Toxoplasma gondii ABC1 family protein 0.0109 0.0194 0.1524
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0194 0.3847
Onchocerca volvulus 0.0022 0.0015 0.0229
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0315 0.467
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0166 0.0312 0.1064
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0034 0.004 0.0282
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0048 0.0303
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0166 0.0312 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0028 0.0466
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0034 0.004 0.0588
Echinococcus multilocularis geminin 0.0536 0.1078 0.1078
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0713 0.1442 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0052 0.0182
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0202 0.1407
Onchocerca volvulus 0.0022 0.0015 0.0229
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0015 0.008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0166 0.0312 0.1064
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0166 0.0312 0.3199
Loa Loa (eye worm) hypothetical protein 0.0109 0.0194 0.1987
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0015 0.008
Echinococcus granulosus bloom syndrome protein 0.005 0.0072 0.0246
Loa Loa (eye worm) hypothetical protein 0.0109 0.0194 0.1987
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0085
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0034 0.004 0.3
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0034 0.004 0.004
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0121 0.0414
Plasmodium falciparum thioredoxin reductase 0.0049 0.0071 0.5394
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0034 0.004 0.025
Entamoeba histolytica recQ family DNA helicase 0.0018 0.0006 0.0119
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0015 0.0054
Brugia malayi cytoplasmic intermediate filament protein 0.0061 0.0095 0.0978
Echinococcus granulosus neuropeptide receptor A26 0.1434 0.2933 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0015 0.0054
Loa Loa (eye worm) hypothetical protein 0.0053 0.008 0.0816
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0166 0.0312 0.3199
Loa Loa (eye worm) CYP4Cod1 0.004 0.0052 0.0533
Echinococcus granulosus chromobox protein 1 0.0071 0.0116 0.0395
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0015 0.0015
Onchocerca volvulus 0.0341 0.0675 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0166 0.0312 0.3199
Echinococcus multilocularis lamin dm0 0.0114 0.0205 0.0205
Brugia malayi Cytochrome P450 family protein 0.004 0.0052 0.0533
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0015 0.0071
Leishmania major cytochrome p450-like protein 0.004 0.0052 0.0381
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0232 0.0448 0.1528
Echinococcus multilocularis thyroid hormone receptor alpha 0.0166 0.0312 0.0312
Leishmania major trypanothione reductase 0.0049 0.0071 0.0536
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0128 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0035 0.0041 0.0041
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.0173 0.0589
Onchocerca volvulus 0.0114 0.0205 0.3032
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0034 0.004 0.025
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0128 1
Entamoeba histolytica Ran family GTPase 0.0023 0.0017 0.1079
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0034 0.004 0.0243
Loa Loa (eye worm) intermediate filament protein 0.0114 0.0205 0.2098
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0034 0.004 0.0243
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0166 0.0312 0.0312
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.0173 0.1771
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0085
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0034 0.004 0.004
Brugia malayi hypothetical protein 0.0129 0.0236 0.2419
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0085
Brugia malayi hypothetical protein 0.0022 0.0015 0.0158
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0015 0.0054
Brugia malayi Nuclear hormone receptor-like 1 0.0151 0.0282 0.2886
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0052 0.0764
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0034 0.004 0.0282
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0052 0.0332
Leishmania major aldehyde dehydrogenase, putative 0.0034 0.004 0.0282
Plasmodium falciparum glutathione reductase 0.0049 0.0071 0.5394
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0232 0.0448 0.1528
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0166 0.0312 0.3199
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0082 0.0286
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0713 0.1442 1
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0334 0.066 0.2294
Echinococcus multilocularis bloom syndrome protein 0.005 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0052 0.0953
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0015 0.0201
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0618 0.1246 0.8875
Onchocerca volvulus 0.0109 0.0194 0.2872
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0055 0.0083 0.0083
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0166 0.0312 0.1084
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0015 0.0071
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0047 0.0297
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.008 0.0277
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.006 0.0208
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0128 0.0993
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0052 0.0332
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0015 0.008
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0015 0.0071
Plasmodium vivax glutathione reductase, putative 0.0049 0.0071 0.3522
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0033 0.0572
Schistosoma mansoni retinoic acid receptor RXR 0.0166 0.0312 0.1084
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0034 0.004 0.0243
Schistosoma mansoni hypothetical protein 0.0022 0.0015 0.0051
Schistosoma mansoni lamin 0.0114 0.0205 0.0711
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0052 0.0052
Schistosoma mansoni mixed-lineage leukemia protein mll 0.018 0.0341 0.1183
Brugia malayi nuclear receptor NHR-88 0.0166 0.0312 0.3199
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0202 0.1407
Brugia malayi CHD4 protein 0.0016 0.0003 0.0034
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0713 0.1442 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0618 0.1246 1
Brugia malayi Cytochrome P450 family protein 0.0022 0.0015 0.0151
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0048 0.3539
Brugia malayi intermediate filament protein 0.0114 0.0205 0.2098
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0121 0.0811
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0015 0.0069
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0015 0.008
Echinococcus granulosus microtubule associated protein 2 0.1408 0.2879 0.9818
Schistosoma mansoni hypothetical protein 0.0034 0.0041 0.0141
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0036 0.0036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0194 0.0673
Loa Loa (eye worm) hypothetical protein 0.0166 0.0312 0.3199
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0052 0.0533
Mycobacterium ulcerans aldehyde dehydrogenase 0.0618 0.1246 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0121 0.2371
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0048 0.3753
Schistosoma mansoni hypothetical protein 0.0098 0.0173 0.06
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0015 0.0071
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0487 0.0976 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0236 0.2419
Brugia malayi nuclear hormone receptor 0.0166 0.0312 0.3199
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.0496 0.5088
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0048 0.562
Onchocerca volvulus Huntingtin homolog 0.0129 0.0236 0.3498
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0121 0.2371
Echinococcus multilocularis glycoprotein Antigen 5 0.0022 0.0015 0.0015
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0034 0.004 0.0243
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0121 0.0939
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0334 0.6693
Onchocerca volvulus 0.0022 0.0015 0.0229
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0048 0.0165
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0194 0.1353
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0334 0.6693
Schistosoma mansoni ran 0.0023 0.0017 0.0059
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 0.0519 0.1042 0.7214
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0034 0.004 0.3014
Loa Loa (eye worm) cytochrome P450 family protein 0.0101 0.0177 0.1817
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.007
Schistosoma mansoni DNA helicase recq1 0.0035 0.0041 0.0142
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0121 0.2371
Schistosoma mansoni RAR-like nuclear receptor 0.0166 0.0312 0.1084
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0047 0.0297
Toxoplasma gondii histone lysine methyltransferase SET1 0.0161 0.0301 0.239
Giardia lamblia Alcohol dehydrogenase 0.0034 0.004 0.4507
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0158
Loa Loa (eye worm) hypothetical protein 0.0166 0.0312 0.3199
Schistosoma mansoni aldehyde dehydrogenase 0.0618 0.1246 0.4327
Brugia malayi Intermediate filament tail domain containing protein 0.0114 0.0205 0.2098
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0035 0.0041 0.0419
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0052 0.4107
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0194 0.1353
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0015 0.0071
Echinococcus granulosus geminin 0.0536 0.1078 0.3676
Trypanosoma brucei trypanothione reductase 0.0049 0.0071 0.0462
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0166 0.0312 0.1084
Echinococcus multilocularis lamin 0.0114 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0166 0.0312 0.3199
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0058 0.0857
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0015 0.008
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0194 0.0194
Schistosoma mansoni steroid hormone receptor ad4bp 0.0166 0.0312 0.1084
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0015 0.0054
Onchocerca volvulus 0.0319 0.0629 0.9319
Brugia malayi MH2 domain containing protein 0.0124 0.0225 0.2304
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0015 0.008
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0015 0.008
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0022 0.035
Onchocerca volvulus 0.0051 0.0074 0.1098
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0041 0.0292
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0017 0.1596
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0034 0.004 0.0135
Trypanosoma brucei protein kinase, putative 0.0055 0.0082 0.054
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0071 0.0243
Loa Loa (eye worm) hypothetical protein 0.0109 0.0194 0.1987
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0034 0.004 0.0243
Schistosoma mansoni hypothetical protein 0.0536 0.1078 0.3744
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0015 0.008
Onchocerca volvulus 0.0243 0.0471 0.6984
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0015 0.0054
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0052 0.0533
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0315 0.6315
Loa Loa (eye worm) hypothetical protein 0.004 0.0052 0.0529
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0015 0.0054
Entamoeba histolytica recQ family helicase, putative 0.0038 0.0047 0.3671
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0128 0.0857
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0496 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0022 0.035
Loa Loa (eye worm) hypothetical protein 0.0109 0.0194 0.1987
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0034 0.004 0.0282
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0618 0.1246 1
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0194 0.3847
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0022 0.0015 0.0053
Loa Loa (eye worm) hypothetical protein 0.0151 0.0282 0.2886
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0034 0.004 0.0407
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0017 0.0175
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0015 0.0054
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0034 0.004 0.0282
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0026 0.0026
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0005 0.0016
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.0496 0.5088
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0166 0.0312 0.1084
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.0173 0.1771
Schistosoma mansoni inositol monophosphatase 0.0073 0.0121 0.0421
Brugia malayi Nuclear hormone receptor-like 1 0.0166 0.0312 0.3199
Loa Loa (eye worm) hypothetical protein 0.0166 0.0312 0.3199
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0034 0.004 0.0282
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0034 0.004 0.004
Echinococcus multilocularis dnaJ subfamily B 0.0801 0.1625 0.1625
Onchocerca volvulus 0.0109 0.0194 0.2872
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0034 0.004 0.0282
Brugia malayi hypothetical protein 0.005 0.0072 0.0736
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0034 0.004 0.025
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0496 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0114 0.0205 0.2098
Trypanosoma brucei hypothetical protein, conserved 0.0713 0.1442 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0129 0.0236 0.2419
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0052 0.0385
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0194 0.3847
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0015 0.0015
Loa Loa (eye worm) steroid hormone receptor 0.0166 0.0312 0.3199
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0022 0.0015 0.0158
Brugia malayi Inositol-1 0.0073 0.0121 0.1243
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0015 0.0054
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0034 0.004 0.3014
Schistosoma mansoni aldehyde dehydrogenase 0.0034 0.004 0.0138
Echinococcus multilocularis enteropeptidase 0.0022 0.0015 0.0015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0166 0.0312 0.1064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.0411 0.4211
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0232 0.0448 0.0448
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0202 0.1407
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0036 0.0125
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0034 0.004 0.3014
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0082 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0166 0.0312 0.3199
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0015 0.0071
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0041 0.0292
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0048 0.0048
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0048 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0166 0.0312 0.3199
Loa Loa (eye worm) hypothetical protein 0.0311 0.0612 0.6272
Schistosoma mansoni chromobox protein 0.0071 0.0116 0.0403
Schistosoma mansoni blooms syndrome DNA helicase 0.0032 0.0036 0.0124
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0034 0.004 0.0282
Echinococcus granulosus snurportin 1 0.0334 0.066 0.2252
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0085
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0202 0.1407
Loa Loa (eye worm) hypothetical protein 0.0213 0.0409 0.4189
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0315 0.6315
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0713 0.1442 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0015 0.0054
Brugia malayi hypothetical protein 0.0077 0.0128 0.1311
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0005 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0015 0.0071
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0194 0.3847
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0194 0.3847
Trichomonas vaginalis set domain proteins, putative 0.0243 0.0471 0.9491
Brugia malayi cytochrome P450 0.0022 0.0015 0.0151
Echinococcus multilocularis chromobox protein 1 0.0071 0.0116 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0085
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0022 0.035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0232 0.0448 0.1556
Onchocerca volvulus 0.0044 0.006 0.0889
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0015 0.0071
Trichomonas vaginalis DNA helicase recq, putative 0.0038 0.0047 0.0867
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0015 0.0051
Mycobacterium ulcerans hypothetical protein 0.0022 0.0015 0.0087
Schistosoma mansoni aldehyde dehydrogenase 0.0034 0.004 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0166 0.0312 0.3199
Leishmania major aldehyde dehydrogenase, putative 0.0034 0.004 0.0282
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0166 0.0312 0.1084
Schistosoma mansoni lamin 0.0114 0.0205 0.0711
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.006
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0034 0.004 0.0407
Trypanosoma brucei hypothetical protein, conserved 0.0713 0.1442 1
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0496 1
Brugia malayi ecdysteroid receptor 0.0166 0.0312 0.3199
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0071 0.3522
Brugia malayi aldehyde dehydrogenase 0.0034 0.004 0.0407
Schistosoma mansoni ap endonuclease 0.0038 0.0048 0.0168
Echinococcus granulosus dnaJ subfamily B 0.0801 0.1625 0.5541
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0052 0.0971
Leishmania major pyroglutamyl-peptidase I (C15 family) 0.0519 0.1042 0.8355
Schistosoma mansoni cpg binding protein 0.0089 0.0153 0.0533
Loa Loa (eye worm) hypothetical protein 0.0114 0.0205 0.2098
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0034 0.004 0.0282
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0166 0.0312 0.1084
Brugia malayi latrophilin 2 splice variant baaae 0.0213 0.0409 0.4189
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0048 0.0303
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0334 0.066 0.6768
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0151 0.0282 0.0978
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0496 1
Onchocerca volvulus 0.0109 0.0194 0.2872
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0315 0.6315
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0035 0.0041 0.0139
Brugia malayi hypothetical protein 0.0151 0.0282 0.2886
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0015 0.0071
Trichomonas vaginalis ran, putative 0.0023 0.0017 0.0252
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0017 0.01
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0071 0.073
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0232 0.0448 0.0448
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0033 0.0572
Schistosoma mansoni hypothetical protein 0.0213 0.0409 0.142
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0034 0.0205
Toxoplasma gondii exonuclease III APE 0.0038 0.0048 0.0351
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0034 0.004 0.0138
Brugia malayi Latrophilin receptor protein 2 0.0098 0.0173 0.1771
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0166 0.0312 0.1064
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0071 0.0071
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0003 0.0011
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0034 0.004 0.0135
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0166 0.0312 0.4624
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0166 0.0312 0.1064
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0015 0.0051
Plasmodium vivax SET domain protein, putative 0.0032 0.0036 0.1666
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0052 0.0538
Schistosoma mansoni hypothetical protein 0.0098 0.0173 0.06
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0035 0.0041 0.0139
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0052 0.0179
Entamoeba histolytica hypothetical protein 0.0025 0.0022 0.1494
Loa Loa (eye worm) hypothetical protein 0.0166 0.0312 0.3199
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0225 0.2304
Brugia malayi glutathione reductase 0.0049 0.0071 0.073
Brugia malayi Pre-SET motif family protein 0.0214 0.0411 0.4211
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0034 0.004 0.0282
Schistosoma mansoni aldehyde dehydrogenase 0.0034 0.004 0.0138
Brugia malayi Calcitonin receptor-like protein seb-1 0.0311 0.0612 0.6272
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0052 0.0332
Echinococcus granulosus intermediate filament protein 0.0114 0.0205 0.0698
Loa Loa (eye worm) inositol-1 0.0073 0.0121 0.1243
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0015 0.0071
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0034 0.004 0.0407
Brugia malayi beta-lactamase family protein 0.0109 0.0194 0.1987
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0035 0.0041 0.0041
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0121 0.0939
Brugia malayi nuclear receptor RXR 0.0151 0.0282 0.2886
Schistosoma mansoni hypothetical protein 0.0536 0.1078 0.3744
Brugia malayi photoreceptor-specific nuclear receptor 0.0166 0.0312 0.3199
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0036 0.0123
Loa Loa (eye worm) CXXC zinc finger family protein 0.0084 0.0143 0.147
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0052 0.0179
Loa Loa (eye worm) hypothetical protein 0.0053 0.0079 0.0806
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0018 0.0006 0.0008
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0202 0.8783
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0082 0.0082
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0194 0.1353
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0166 0.0312 0.3199
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0232 0.0448 0.4593
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0194 0.1524
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0015 0.008
Echinococcus granulosus transmembrane protease serine 3 0.0022 0.0015 0.0053
Schistosoma mansoni hypothetical protein 0.0098 0.0173 0.06
Echinococcus granulosus lamin 0.0114 0.0205 0.0698
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0015 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0232 0.0448 0.1556
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0315 0.6315
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0015 0.0054
Onchocerca volvulus 0.0114 0.0205 0.3032
Echinococcus multilocularis tumor protein p63 0.0364 0.0722 0.0722
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0034 0.004 0.0282
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0311 0.0612 0.6272
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.003 0.0102
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0041 0.0419
Brugia malayi Importin beta-1 subunit 0.0031 0.0034 0.035
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0034 0.004 0.025
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0082 0.054
Loa Loa (eye worm) cytochrome P450 0.0022 0.0015 0.0151
Loa Loa (eye worm) hypothetical protein 0.0151 0.0282 0.2886
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0248 0.0483 0.4946
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0041 0.0419
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0311 0.0612 0.6272
Leishmania major cytochrome p450-like protein 0.0022 0.0015 0.008
Plasmodium falciparum importin beta, putative 0.0031 0.0034 0.2392
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0034 0.004 0.0243
Brugia malayi hypothetical protein 0.0151 0.0282 0.2886
Brugia malayi Aldehyde dehydrogenase protein 4 0.0034 0.004 0.0407
Schistosoma mansoni cpg binding protein 0.0089 0.0153 0.0533
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0034 0.004 0.0282
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0058 0.108
Echinococcus granulosus lamin dm0 0.0114 0.0205 0.0698
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0015 0.008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0166 0.0312 0.3199
Echinococcus granulosus tumor protein p63 0.0364 0.0722 0.2463

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 120 uM Inhibition of f11a ChEMBL. 16876411
Potency (functional) = 0.0891 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen)] ChEMBL. No reference
Potency (functional) = 0.0891 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from structural similarity (ECO:0000027) Leishmania major 23720  
Annotator: aaronjr@u.washington.edu Comment: Drug: 26305-03-3. chemical inhibition with known cysteine peptidase inhibitors leads to reduced enzyme activity in vitro; References: 17028008
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major 23720  
Annotator: aaronjr@u.washington.edu Comment: Drug: 26305-03-3. chemical inhibition with known cysteine peptidase inhibitors leads to reduced enzyme activity in vitro; References: 17028008

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.