Detailed information for compound 828254

Basic information

Technical information
  • TDR Targets ID: 828254
  • Name: 7-[(2-chloro-5-methoxyphenyl)methyl]-8-(3-hyd roxypropylamino)-1,3-dimethylpurine-2,6-dione
  • MW: 407.851 | Formula: C18H22ClN5O4
  • H donors: 2 H acceptors: 4 LogP: 2.3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCNc1nc2c(n1Cc1cc(OC)ccc1Cl)c(=O)n(c(=O)n2C)C
  • InChi: 1S/C18H22ClN5O4/c1-22-15-14(16(26)23(2)18(22)27)24(17(21-15)20-7-4-8-25)10-11-9-12(28-3)5-6-13(11)19/h5-6,9,25H,4,7-8,10H2,1-3H3,(H,20,21)
  • InChiKey: WKZWTBJUIXXYDH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-[(2-chloro-5-methoxy-phenyl)methyl]-8-(3-hydroxypropylamino)-1,3-dimethyl-purine-2,6-dione
  • 7-(2-chloro-5-methoxy-benzyl)-8-(3-hydroxypropylamino)-1,3-dimethyl-xanthine
  • ZINC02359491
  • MLS000039385
  • SMR000037528
  • TULIP028989

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus calcium activated potassium channel 0.0078 0.0622 0.1188
Brugia malayi SRC-1 0.0058 0.0373 0.0361
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0299 0.3481 1
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0895 0.3256
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0083 0.0697 0.0684
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0094 0.0831 0.3098
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0094 0.0831 0.1605
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0069 0.0507 0.1929
Echinococcus granulosus titin 0.0037 0.0091 0.0132
Plasmodium falciparum serine/threonine protein kinase 0.0068 0.05 0.3741
Entamoeba histolytica protein kinase domain containing protein 0.0102 0.0933 0.2414
Trichomonas vaginalis AGC family protein kinase 0.0114 0.1087 0.3965
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0083 0.0697 0.2587
Echinococcus granulosus casein kinase I alpha 0.009 0.0783 0.1508
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.004 0.0131 0.0442
Echinococcus granulosus defective proboscis extension response 0.0041 0.0152 0.0252
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.1118 0.4081
Plasmodium vivax calcium-dependent protein kinase, putative 0.0083 0.0697 0.5251
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0168 0.1794 0.3521
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0074 0.057 0.2174
Schistosoma mansoni hypothetical protein 0.0052 0.0293 0.0604
Plasmodium falciparum NIMA related kinase 2 0.0041 0.0142 0.0985
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0099 0.0895 0.0883
Entamoeba histolytica protein kinase, putative 0.0116 0.1118 0.2901
Echinococcus granulosus ephrin type A receptor 4 A 0.0069 0.051 0.0965
Mycobacterium ulcerans hypothetical protein 0.0087 0.0741 0.5
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0058 0.0365 0.0676
Entamoeba histolytica protein kinase, putative 0.0057 0.0361 0.0911
Entamoeba histolytica diacylglycerol kinase, putative 0.0036 0.008 0.0172
Loa Loa (eye worm) hypothetical protein 0.0041 0.0154 0.0141
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.2181 0.449
Trichomonas vaginalis CMGC family protein kinase 0.0069 0.0507 0.1823
Plasmodium vivax serine/threonine-protein kinase Nek1, putative 0.0041 0.0142 0.0985
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0065 0.0133
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0074 0.057 0.2174
Entamoeba histolytica serine/threonine protein kinase, putative 0.0041 0.0142 0.0336
Echinococcus granulosus Vam6:Vps39 protein 0.0096 0.0853 0.1648
Echinococcus granulosus dual specificity protein kinase clk2 0.0129 0.1281 0.2499
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0037 0.0094 0.0136
Leishmania major protein kinase, putative 0.0031 0.0014 0.0056
Loa Loa (eye worm) hypothetical protein 0.0122 0.1197 0.1185
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0103 0.0955 0.3477
Schistosoma mansoni atypical protein kinase C 0.0241 0.2731 0.5622
Brugia malayi Doublecortin family protein 0.0126 0.1249 0.1238
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0074 0.057 0.0558
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0058 0.0373 0.0693
Loa Loa (eye worm) AGC/NDR protein kinase 0.0129 0.1284 0.1272
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0122 0.119 0.9052
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0071 0.0533 0.101
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0067 0.0482 0.047
Plasmodium falciparum protein serine/threonine kinase-1 0.0129 0.1281 0.9746
Brugia malayi Immunoglobulin I-set domain containing protein 0.0108 0.1018 0.1006
Echinococcus multilocularis serine:threonine protein kinase N2 0.0129 0.1284 0.2505
Trypanosoma cruzi cdc2-related kinase 3 0.0099 0.0895 0.3446
Onchocerca volvulus Netrin receptor homolog 0.0034 0.0056 0.0123
Loa Loa (eye worm) hypothetical protein 0.0102 0.0933 0.0921
Trichomonas vaginalis CMGC family protein kinase 0.0069 0.0507 0.1823
Echinococcus granulosus serine:threonine kinase SAD 1 0.0074 0.057 0.1084
Echinococcus granulosus calcium dependent protein kinase 0.0058 0.0368 0.0682
Echinococcus granulosus serine/threonine protein kinase 0.0136 0.1382 0.2701
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.176 0.3624
Trichomonas vaginalis CK1 family protein kinase 0.009 0.0783 0.2841
Schistosoma mansoni tyrosine kinase 0.0033 0.0049 0.0101
Leishmania major serine/threonine-protein kinase, putative 0.0041 0.0142 0.0553
Brugia malayi Protein kinase domain containing protein 0.0163 0.1724 0.1713
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0169 0.1801 0.3535
Schistosoma mansoni tyrosine kinase 0.0118 0.115 0.2367
Giardia lamblia Kinase, CMGC CDK 0.0099 0.0895 0.3101
Echinococcus multilocularis Diacylglycerol kinase theta 0.0036 0.008 0.0109
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0129 0.1284 0.1272
Onchocerca volvulus Serine\/threonine kinase homolog 0.0137 0.1396 0.3988
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0107 0.1004 0.3873
Echinococcus granulosus dual specificity 0.0102 0.0933 0.1807
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0067 0.0482 0.047
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0843 0.3065
Loa Loa (eye worm) casein kinase 0.0154 0.1611 0.16
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0041 0.0142 0.0501
Echinococcus multilocularis casein kinase I alpha 0.009 0.0783 0.1508
Loa Loa (eye worm) hypothetical protein 0.0045 0.0204 0.0191
Loa Loa (eye worm) hypothetical protein 0.0119 0.1152 0.1141
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0096 0.0853 0.1648
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0507 0.1045
Trypanosoma brucei cdc2-related kinase 1 0.0099 0.0895 0.3256
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0895 0.1843
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0131 0.1314 1
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0183 0.1988 0.1978
Schistosoma mansoni protein kinase 0.0173 0.1851 0.381
Trypanosoma brucei protein kinase, putative 0.0069 0.0507 0.1823
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0068 0.0503 0.0951
Loa Loa (eye worm) hypothetical protein 0.0043 0.0179 0.0166
Schistosoma mansoni serine/threonine kinase 0.0078 0.0622 0.1281
Giardia lamblia Kinase, CMGC CK2 0.0083 0.0689 0.225
Schistosoma mansoni serine/threonine protein kinase 0.0275 0.3178 0.6542
Giardia lamblia Kinase, CMGC SRPK 0.0068 0.05 0.1475
Loa Loa (eye worm) hypothetical protein 0.0198 0.2183 0.2172
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0368 0.4381 0.8669
Giardia lamblia Kinase, PLK 0.0228 0.2571 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0099 0.0895 0.1732
Trypanosoma brucei protein kinase, putative 0.004 0.0131 0.043
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0187 0.2039 0.4008
Brugia malayi Protein kinase domain containing protein 0.0129 0.1284 0.1272
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0129 0.1281 0.4954
Echinococcus multilocularis mitogen activated protein kinase 14 0.0133 0.1341 0.2619
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0311 0.3638 0.363
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0116 0.1118 0.4187
Entamoeba histolytica protein kinase, putative 0.0058 0.0365 0.0921
Plasmodium falciparum NIMA related kinase 1 0.0114 0.1087 0.8256
Loa Loa (eye worm) RasGEF domain-containing protein 0.0036 0.008 0.0067
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.005 0.027 0.0487
Schistosoma mansoni protein kinase 0.0173 0.1851 0.381
Trypanosoma brucei casein kinase I, isoform 2 0.009 0.0783 0.2841
Plasmodium vivax glycogen synthase kinase 3, putative 0.0107 0.1004 0.762
Echinococcus granulosus mitogen activated protein kinase 0.0069 0.0507 0.096
Onchocerca volvulus 0.0107 0.1004 0.2859
Plasmodium falciparum calcium-dependent protein kinase 2 0.0083 0.0697 0.5251
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0071 0.0533 0.101
Echinococcus granulosus raf serine:threonine protein kinase 0.005 0.0265 0.0477
Echinococcus multilocularis protein kinase c iota type 0.0235 0.2663 0.5251
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0083 0.0689 0.0676
Echinococcus multilocularis expressed conserved protein 0.0112 0.107 0.2079
Brugia malayi casein kinase I 0.009 0.0783 0.0771
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0102 0.0933 0.0921
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0067
Brugia malayi Variant SH3 domain containing protein 0.0042 0.0164 0.0151
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0112 0.107 0.2079
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.1118 0.4081
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0058 0.0365 0.0676
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0112 0.107 0.4003
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0895 0.1843
Brugia malayi Protein kinase domain containing protein 0.0076 0.0596 0.0584
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Echinococcus multilocularis PAK box P21 Rho binding 0.0052 0.0293 0.0532
Toxoplasma gondii NEK kinase 0.0041 0.0142 0.0485
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0078 0.0622 0.061
Echinococcus granulosus casein kinase i 0.009 0.0783 0.1508
Echinococcus multilocularis calcium activated potassium channel 0.0078 0.0622 0.1188
Echinococcus granulosus serine threonine protein kinase nrc 0.0131 0.1314 0.2564
Brugia malayi Homeodomain interacting protein kinase protein 1 0.017 0.1822 0.1812
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0137 0.1396 0.2729
Echinococcus granulosus aurora kinase A 0.0122 0.119 0.2319
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0186 0.0382
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0099 0.0895 0.0883
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0068 0.05 0.1947
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.0373 0.0693
Brugia malayi Kinase associated domain 1 family protein 0.0052 0.0293 0.0281
Entamoeba histolytica PH domain containing protein kinase, putative 0.0099 0.09 0.2326
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0046 0.0209 0.0197
Echinococcus granulosus STE20 serine:threonine protein kinase 0.042 0.5049 1
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0044 0.0186 0.0634
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0107 0.1004 0.3907
Schistosoma mansoni serine/threonine protein kinase 0.0201 0.2214 0.4559
Trypanosoma brucei SNF1-related protein kinases, putative 0.0074 0.057 0.2054
Echinococcus granulosus neuroglian 0.0051 0.0271 0.0489
Echinococcus multilocularis neuroglian 0.0051 0.0271 0.0489
Schistosoma mansoni tyrosine kinase 0.0033 0.0039 0.0081
Loa Loa (eye worm) hypothetical protein 0.0247 0.2819 0.2809
Schistosoma mansoni protein kinase 0.0311 0.3638 0.749
Echinococcus granulosus c-Jun N-terminal kinases 0.0223 0.2504 0.4934
Brugia malayi serine/threonine-protein kinase 6 0.0122 0.119 0.1179
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0083 0.0689 0.5189
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.0373 0.0693
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0147 0.1526 0.1515
Loa Loa (eye worm) SRC-1 0.0058 0.0373 0.0361
Loa Loa (eye worm) hypothetical protein 0.0096 0.0853 0.0841
Echinococcus granulosus dual specificity 0.0116 0.1118 0.2176
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0223 0.2504 0.2494
Echinococcus granulosus protein kinase 0.0128 0.1275 0.2488
Schistosoma mansoni kinase 0.0244 0.2775 0.5713
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0094 0.0831 0.1605
Trypanosoma cruzi casein kinase, putative 0.009 0.0783 0.3007
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0094 0.0831 0.1605
Schistosoma mansoni tyrosine kinase 0.0192 0.2102 0.4328
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0168 0.1794 0.3521
Trypanosoma brucei aurora B kinase 0.0122 0.119 0.4347
Trypanosoma brucei NIMA-related protein kinase 0.0041 0.0142 0.0473
Trypanosoma cruzi cdc2-related kinase 1 0.0099 0.0895 0.3446
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0094 0.0831 0.3196
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0095 0.0843 0.0831
Echinococcus multilocularis myosin iiia 0.007 0.0518 0.098
Loa Loa (eye worm) hypothetical protein 0.0073 0.0567 0.0554
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0198 0.2181 0.429
Onchocerca volvulus 0.0065 0.0455 0.1273
Echinococcus multilocularis tyrosine protein kinase Abl 0.0033 0.0049 0.0048
Plasmodium falciparum cGMP-dependent protein kinase 0.0112 0.107 0.8125
Brugia malayi Protein kinase domain containing protein 0.0166 0.1768 0.1757
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0083 0.0697 0.1336
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0069 0.0507 0.1974
Schistosoma mansoni protein kinase 0.0083 0.0689 0.1418
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0096 0.0853 0.1648
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0094 0.0831 0.6289
Giardia lamblia Kinase, STE STE20 0.0071 0.0533 0.1608
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0041 0.0152 0.0313
Plasmodium vivax unspecified product 0.0083 0.0689 0.5189
Onchocerca volvulus 0.0122 0.1197 0.3414
Leishmania major protein kinase, putative 0.0083 0.0697 0.271
Echinococcus granulosus serine:threonine protein kinase N2 0.0111 0.1051 0.2042
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0122 0.119 0.309
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0114 0.1087 0.8256
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0083 0.0697 0.5251
Echinococcus granulosus Glutaredoxin protein 5 0.0106 0.0985 0.191
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0689 0.2492
Brugia malayi diacylglycerol kinase 0.0036 0.008 0.0067
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0083 0.0697 0.0684
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.1118 0.4081
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0365 0.0751
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0129 0.1284 0.2505
Entamoeba histolytica protein kinase, putative 0.0084 0.0711 0.1829
Echinococcus multilocularis serine:threonine protein kinase N2 0.0111 0.1051 0.2042
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0217 0.2422 0.2412
Loa Loa (eye worm) hypothetical protein 0.0061 0.0411 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Trypanosoma cruzi cdc2-related kinase 1 0.0099 0.0895 0.3446
Trichomonas vaginalis STE family protein kinase 0.0114 0.1087 0.3965
Echinococcus multilocularis Immunoglobulin 0.0041 0.0152 0.0252
Brugia malayi hypothetical protein 0.0096 0.0853 0.0841
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0099 0.0895 0.0883
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0058 0.0365 0.0676
Loa Loa (eye worm) AGC/PKA protein kinase 0.0094 0.0831 0.0819
Loa Loa (eye worm) AUR protein kinase 0.0122 0.119 0.1179
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0099 0.0895 0.3483
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0121 0.1182 0.2302
Onchocerca volvulus 0.009 0.0783 0.222
Schistosoma mansoni serine/threonine protein kinase 0.0334 0.3941 0.8115
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0689 0.2492
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0031 0.0014 0.0056
Brugia malayi Cam kinase protein 1 0.0083 0.0697 0.0684
Onchocerca volvulus 0.0055 0.0325 0.09
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0137 0.1396 0.2729
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0074 0.057 0.2054
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0147 0.152 0.2974
Brugia malayi casein kinase 1, delta 0.009 0.0783 0.0771
Echinococcus granulosus casein kinase ii subunit alpha 0.0083 0.0689 0.132
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0036 0.008 0.0067
Loa Loa (eye worm) TK/INSR protein kinase 0.0166 0.1768 0.1757
Echinococcus multilocularis casein kinase I delta 0.009 0.0783 0.1508
Loa Loa (eye worm) hypothetical protein 0.0096 0.0853 0.0841
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.0373 0.0693
Entamoeba histolytica protein kinase domain containing protein 0.0116 0.1118 0.2901
Loa Loa (eye worm) hypothetical protein 0.0037 0.0094 0.0081
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0083 0.0697 0.1336
Trichomonas vaginalis AGC family protein kinase 0.0129 0.1284 0.4692
Echinococcus multilocularis casein kinase I alpha 0.009 0.0783 0.1508
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0179 0.0166
Trichomonas vaginalis CMGC family protein kinase 0.0069 0.0507 0.1823
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0114 0.1087 0.4068
Trichomonas vaginalis STE family protein kinase 0.0071 0.0533 0.1916
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0041 0.0142 0.0501
Giardia lamblia Kinase, AGC PKA 0.0131 0.1314 0.4824
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.007 0.0518 0.1322
Brugia malayi Protein kinase domain containing protein 0.0162 0.1714 0.1703
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0482 0.173
Leishmania major protein kinase, putative 0.007 0.0518 0.2014
Trichomonas vaginalis AGC family protein kinase 0.024 0.272 1
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0107 0.1004 0.3755
Schistosoma mansoni ste20-related kinase 0.0173 0.185 0.3809
Brugia malayi Protein kinase domain containing protein 0.005 0.0266 0.0253
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0074 0.057 0.4278
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0083 0.0697 0.2587
Trypanosoma brucei Serine/threonine-protein kinase NEK11, putative 0.0041 0.0142 0.0473
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0074 0.057 0.2218
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0116 0.1118 0.4081
Trichomonas vaginalis AGC family protein kinase 0.0122 0.119 0.4347
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0196 0.2148 0.2138
Echinococcus multilocularis tyrosine protein kinase Blk 0.0046 0.021 0.0368
Brugia malayi Protein kinase domain containing protein 0.0381 0.4543 0.4535
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0131 0.1314 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0179 0.194 0.1929
Echinococcus multilocularis 0.0054 0.0321 0.0589
Echinococcus multilocularis tyrosine protein kinase HCK 0.0039 0.0126 0.0201
Echinococcus multilocularis insulin receptor 0.0166 0.1768 0.3468
Entamoeba histolytica casein kinase, putative 0.0083 0.0689 0.1771
Entamoeba histolytica hypothetical protein 0.0036 0.008 0.0172
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0116 0.1118 0.4319
Loa Loa (eye worm) AUR protein kinase 0.0122 0.119 0.1179
Plasmodium falciparum calcium-dependent protein kinase 4 0.0083 0.0697 0.5251
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0068 0.05 0.1902
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.004 0.0131 0.043
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Echinococcus granulosus casein kinase I delta 0.009 0.0783 0.1508
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0103 0.0945 0.3675
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0065 0.0455 0.1722
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.037 0.4407 0.8722
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0069 0.0507 0.187
Entamoeba histolytica protein kinase 2, putative 0.0131 0.1314 0.3413
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0156 0.1636 0.3207
Loa Loa (eye worm) hypothetical protein 0.0163 0.1728 0.1717
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.152 0.3129
Echinococcus multilocularis dual specificity 0.0116 0.1118 0.2176
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.0622 0.2246
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0116 0.1118 0.4351
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.1284 0.2643
Trichomonas vaginalis STE family protein kinase 0.0052 0.0293 0.1029
Leishmania major protein kinase, putative 0.0031 0.0014 0.0056
Entamoeba histolytica protein kinase domain containing protein 0.0083 0.0689 0.1771
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0094 0.0831 0.6289
Entamoeba histolytica protein kinase domain containing protein 0.0107 0.1004 0.2601
Giardia lamblia Kinase, CMGC CLK 0.0129 0.1281 0.4688
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0129 0.1284 0.2505
Echinococcus granulosus protein kinase c iota type 0.0235 0.2663 0.5251
Trichomonas vaginalis STE family protein kinase 0.007 0.0518 0.186
Brugia malayi Ras association domain family 1 isoform A 0.0036 0.008 0.0067
Trypanosoma brucei Serine/threonine-protein kinase NEK16, putative 0.0041 0.0142 0.0473
Echinococcus multilocularis serine:threonine protein kinase N2 0.024 0.2718 0.5359
Echinococcus granulosus cyclin dependent kinase 0.0099 0.0895 0.1732
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0069 0.0507 0.1929
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0107 0.1004 0.1949
Echinococcus granulosus nervana 2 0.0106 0.0985 0.191
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0129 0.1281 0.4954
Giardia lamblia Kinase, CMGC MAPK 0.0069 0.0507 0.1504
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0622 0.1281
Echinococcus multilocularis cyclin dependent kinase 0.0099 0.0895 0.1732
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0116 0.1118 0.1107
Loa Loa (eye worm) TK/EPH protein kinase 0.0084 0.0704 0.0692
Schistosoma mansoni serine/threonine protein kinase 0.0299 0.3481 0.7167
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Echinococcus granulosus homeodomain interacting protein kinase 3 0.017 0.1822 0.3577
Entamoeba histolytica protein kinase, putative 0.0102 0.0933 0.2414
Giardia lamblia Kinase, CK1 Casein kinase 0.009 0.0783 0.2639
Echinococcus granulosus expressed protein 0.0068 0.05 0.0946
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.107 0.2203
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0381 0.4543 0.4535
Loa Loa (eye worm) AUR protein kinase 0.0122 0.119 0.1179
Schistosoma mansoni tyrosine kinase 0.0118 0.115 0.2367
Entamoeba histolytica serine/threonine protein kinase, putative 0.0074 0.057 0.146
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0083 0.0697 0.1336
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0228 0.2571 0.2561
Plasmodium falciparum glycogen synthase kinase 3 0.0107 0.1004 0.762
Loa Loa (eye worm) hypothetical protein 0.0083 0.0697 0.0684
Echinococcus multilocularis roundabout 2 0.0062 0.0416 0.0777
Loa Loa (eye worm) hypothetical protein 0.0158 0.166 0.1649
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0129 0.1281 0.468
Echinococcus granulosus titin 0.0037 0.0091 0.0132
Echinococcus granulosus casein kinase I alpha 0.009 0.0783 0.1508
Entamoeba histolytica hypothetical protein 0.0325 0.3821 1
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.119 0.2451
Echinococcus granulosus cyclin dependent kinase 1 0.0099 0.0895 0.1732
Echinococcus granulosus unc 13 munc13 0.0037 0.0094 0.0136
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0044 0.0186 0.0173
Schistosoma mansoni tyrosine kinase 0.0166 0.1768 0.3639
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0037 0.0094 0.0136
Brugia malayi Fibronectin type III domain containing protein 0.0043 0.0179 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0067
Trichomonas vaginalis AGC family protein kinase 0.0129 0.1284 0.4692
Brugia malayi RhoGAP domain containing protein 0.0042 0.0164 0.0151
Entamoeba histolytica protein kinase, putative 0.0107 0.1004 0.2601
Schistosoma mansoni serine/threonine protein kinase 0.0199 0.2199 0.4527
Onchocerca volvulus 0.0158 0.166 0.4748
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0107 0.1004 0.1949
Brugia malayi serine/threonine kinase 12 0.0122 0.119 0.1179
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0094 0.0831 0.3196
Plasmodium falciparum protein kinase 5 0.0099 0.0895 0.678
Echinococcus multilocularis mitogen activated protein kinase 11 0.0133 0.1341 0.2619
Echinococcus granulosus Protein kinase C brain isozyme 0.0199 0.2199 0.4326
Echinococcus multilocularis twitchin 0.0035 0.0065 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.0142 0.0473
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0122 0.119 0.309
Entamoeba histolytica protein kinase domain containing protein 0.0122 0.119 0.309
Echinococcus multilocularis serine:threonine protein kinase 38 0.0129 0.1284 0.2505
Echinococcus multilocularis mitogen activated protein kinase 0.0069 0.0507 0.096
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0071 0.0533 0.101
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0067
Loa Loa (eye worm) hypothetical protein 0.0095 0.0843 0.0831
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.2181 0.449
Echinococcus granulosus serine:threonine protein kinase 0.0095 0.0843 0.1629
Brugia malayi Protein kinase domain containing protein 0.0169 0.1802 0.1791
Echinococcus granulosus casein kinase I delta 0.009 0.0783 0.1508
Leishmania major protein kinase A catalytic subunit 0.0094 0.0831 0.3234
Schistosoma mansoni protein kinase 0.0128 0.1275 0.2625
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0285 0.3301 0.3293
Plasmodium vivax serine/threonine protein kinase, putative 0.0068 0.05 0.3741
Loa Loa (eye worm) hypothetical protein 0.0048 0.0242 0.0229
Echinococcus multilocularis myotubularin protein 13 0.0041 0.0148 0.0245
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0096 0.0853 0.3282
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0058 0.0373 0.0693
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0689 0.2492
Echinococcus granulosus protein kinase c eta type 0.0036 0.008 0.0109
Giardia lamblia Kinase, CMGC DYRK 0.0116 0.1118 0.402
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.1281 0.2637
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Giardia lamblia Kinase, CMGC CDK 0.0099 0.0895 0.3101
Toxoplasma gondii NEK kinase 0.0041 0.0142 0.0485
Schistosoma mansoni protein kinase 0.0162 0.1714 0.3529
Plasmodium falciparum NIMA related kinase 4 0.0041 0.0142 0.0985
Trichomonas vaginalis STE family protein kinase 0.0071 0.0533 0.1916
Plasmodium vivax casein kinase 1, putative 0.009 0.0783 0.5917
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Plasmodium vivax serine/threonine kinase-1, putative 0.0129 0.1281 0.9746
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0094 0.0831 0.302
Brugia malayi serine/threonine protein kinase 6 0.0122 0.119 0.1179
Plasmodium falciparum calcium-dependent protein kinase 5 0.0083 0.0697 0.5251
Echinococcus granulosus dual specificity 0.0116 0.1118 0.2176
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.042 0.5049 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.004 0.0131 0.0456
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0133 0.1335 0.2606
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0689 0.2492
Schistosoma mansoni protein kinase C 0.0037 0.0094 0.0193
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0802 1 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0173 0.1851 0.3633
Entamoeba histolytica protein kinase, putative 0.0068 0.05 0.1277
Echinococcus multilocularis dual specificity protein kinase clk2 0.0129 0.1281 0.2499
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.1118 0.4081
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0041 0.0152 0.0252
Plasmodium vivax serine/threonine-protein kinase NEK4, putative 0.0041 0.0142 0.0985
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0129 0.1281 0.1269
Entamoeba histolytica protein kinase domain containing protein 0.017 0.1822 0.475
Plasmodium falciparum serine/threonine protein kinase KIN 0.0074 0.057 0.4278
Brugia malayi Protein kinase domain containing protein 0.0095 0.0843 0.0831
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0106 0.0985 0.191
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0094 0.0831 0.3196
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.2039 0.4198
Plasmodium falciparum calcium-dependent protein kinase 1 0.0083 0.0697 0.5251
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0033 0.0049 0.0101
Loa Loa (eye worm) hypothetical protein 0.0048 0.0242 0.0229
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.007 0.0518 0.1322
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0332 0.3909 0.3901
Schistosoma mansoni protein kinase 0.0071 0.0533 0.1097
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.017 0.1822 0.3577
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0689 0.2492
Schistosoma mansoni unc-13 (munc13) 0.0037 0.0094 0.0193
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0133 0.1341 0.4904
Echinococcus multilocularis titin 0.0037 0.0091 0.0132
Schistosoma mansoni vav2 0.0048 0.0232 0.0478
Schistosoma mansoni cell adhesion molecule 0.0052 0.0297 0.0611
Echinococcus multilocularis serine:threonine protein kinase 0.0095 0.0843 0.1629
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0116 0.1118 0.1107
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0299 0.3481 0.3472
Trypanosoma cruzi p21-activated kinase 3, putative 0.0044 0.0186 0.0671
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0091 0.0188
Giardia lamblia Kinase, NEK 0.0114 0.1087 0.3891
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0094 0.0831 0.1605
Toxoplasma gondii AGC kinase 0.0234 0.2652 1
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0122 0.119 0.2319
Trypanosoma cruzi casein kinase, delta isoform, putative 0.009 0.0783 0.3007
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.107 0.2203
Echinococcus granulosus mitogen activated protein kinase 14 0.0133 0.1341 0.2619
Brugia malayi Protein kinase domain containing protein 0.0129 0.1281 0.1269
Echinococcus multilocularis casein kinase i 0.009 0.0783 0.1508
Loa Loa (eye worm) hypothetical protein 0.006 0.0389 0.0376
Entamoeba histolytica diacylglycerol kinase, putative 0.0036 0.008 0.0172
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0128 0.1275 0.1264
Echinococcus granulosus RNA directed DNA polymerase 0.0034 0.0056 0.0061
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.0257
Loa Loa (eye worm) hypothetical protein 0.0055 0.0325 0.0313
Echinococcus multilocularis nervana 2 0.0106 0.0985 0.191
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0187 0.2039 0.2029
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0689 0.2492
Echinococcus multilocularis activin receptor type 0.004 0.0131 0.021
Brugia malayi Temporarily assigned gene name protein 59 0.0096 0.0853 0.0841
Brugia malayi Protein kinase domain containing protein 0.0068 0.05 0.0488
Brugia malayi Protein kinase domain containing protein 0.0078 0.0622 0.061
Onchocerca volvulus 0.025 0.2849 0.8177
Echinococcus multilocularis serine:threonine protein kinase 3 0.0217 0.2422 0.477
Trypanosoma brucei polo-like protein kinase 0.0228 0.2571 0.9448
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0071 0.0533 0.101
Entamoeba histolytica protein kinase, putative 0.024 0.272 0.7108
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0201 0.2214 0.2204
Echinococcus multilocularis hypothetical protein 0.0052 0.0293 0.0534
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0069 0.0507 0.1974
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0042 0.0164 0.0275
Brugia malayi Protein kinase domain containing protein 0.0129 0.1284 0.1272
Echinococcus multilocularis rho associated protein kinase 0.0275 0.3178 0.6274
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0147 0.152 0.2974
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0083 0.0697 0.5251
Entamoeba histolytica protein kinase, putative 0.0129 0.1284 0.3335
Echinococcus granulosus Diacylglycerol kinase theta 0.0036 0.008 0.0109
Brugia malayi P38 map kinase family protein 2 0.0133 0.1341 0.133
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0133 0.1341 0.133
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.057 0.1174
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0223 0.2504 0.4934
Echinococcus granulosus insulin receptor 0.0166 0.1768 0.3468
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.004 0.0131 0.0456
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0831 0.302
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0099 0.0899 0.1738
Schistosoma mansoni serine/threonine protein kinase 0.0199 0.2199 0.4527
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0083 0.0697 0.1336
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0033 0.0049 0.0048
Loa Loa (eye worm) TK protein kinase 0.0039 0.0126 0.0113
Brugia malayi protein-tyrosine kinase 0.0046 0.021 0.0197
Onchocerca volvulus 0.0096 0.0853 0.2423
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0299 0.3481 0.3472
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0334 0.3941 0.7795
Brugia malayi Protein kinase domain containing protein 0.0102 0.0933 0.0921
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.057 0.1174
Echinococcus granulosus epidermal growth factor receptor 0.0133 0.1335 0.2606
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0032 0.003 0.004
Schistosoma mansoni protein kinase C mu 0.0183 0.1988 0.4094
Brugia malayi hypothetical protein 0.0187 0.2039 0.2029
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.007 0.0518 0.186
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0034 0.0056 0.0061
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0129 0.1281 0.468
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.007 0.0518 0.1969
Loa Loa (eye worm) TK protein kinase 0.0108 0.1018 0.1006
Leishmania major protein kinase, putative 0.0129 0.1281 0.4982
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0482 0.0993
Toxoplasma gondii AGC kinase 0.0094 0.0831 0.3098
Loa Loa (eye worm) hypothetical protein 0.0119 0.1152 0.1141
Echinococcus multilocularis casein kinase I alpha 0.009 0.0783 0.1508
Schistosoma mansoni protein kinase C mu 0.0036 0.008 0.0164
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.1004 0.366
Echinococcus granulosus N chimaerin 0.0042 0.0164 0.0275
Giardia lamblia Kinase, AGC PKA 0.0094 0.0831 0.2838
Echinococcus granulosus roundabout 2 0.0062 0.0416 0.0777
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0036 0.008 0.0067
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.1118 0.4081
Schistosoma mansoni serine/threonine protein kinase 0.0405 0.4857 1
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.057 0.1174
Echinococcus granulosus cGMP dependent protein kinase 0.0112 0.107 0.2079
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0067 0.0482 0.091
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.2402 0.4945
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0979 0.3566
Echinococcus multilocularis dual specificity 0.0116 0.1118 0.2176
Echinococcus granulosus casein kinase I gamma 0.0179 0.194 0.3811
Giardia lamblia Kinase, CAMK CAMKL 0.0074 0.057 0.1762
Onchocerca volvulus 0.0267 0.3071 0.8818
Entamoeba histolytica PH domain containing protein kinase, putative 0.0136 0.1382 0.3593
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0074 0.057 0.1084
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0102 0.0933 0.3595
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0228 0.2571 0.5066
Echinococcus multilocularis dual specificity 0.0102 0.0933 0.1807
Schistosoma mansoni tyrosine kinase 0.0058 0.0373 0.0769
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0199 0.2199 0.4326
Trichomonas vaginalis AGC family protein kinase 0.0122 0.119 0.4347
Giardia lamblia Kinase, CMGC GSK 0.0107 0.1004 0.355
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0096 0.0853 0.1757
Giardia lamblia Aurora kinase 0.0122 0.119 0.4316
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0137 0.1396 0.1385
Plasmodium falciparum casein kinase 1 0.009 0.0783 0.5917
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0186 0.0382
Trichomonas vaginalis AGC family protein kinase 0.0122 0.119 0.4347
Brugia malayi protein unc-22 0.0037 0.0091 0.0078
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0622 0.1281
Brugia malayi Pleckstrin Homology Domain 0.0041 0.0148 0.0135
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.0142 0.0473
Trichomonas vaginalis CK1 family protein kinase 0.009 0.0783 0.2841
Brugia malayi Protein kinase domain containing protein 0.0137 0.1396 0.1385
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0046 0.021 0.0368
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0094 0.0831 0.0819
Echinococcus granulosus epidermal growth factor receptor 0.0192 0.2102 0.4134
Echinococcus granulosus tyrosine protein kinase Src64B 0.0058 0.0373 0.0693
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0122 0.119 0.309
Brugia malayi phosphoinositide-dependent protein kinase I 0.0067 0.0482 0.047
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0096 0.0853 0.3282
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0147 0.152 0.2974
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Entamoeba histolytica protein kinase, putative 0.0067 0.0482 0.123
Schistosoma mansoni rac gtpase activating protein 0.0036 0.008 0.0164
Echinococcus multilocularis protein kinase c eta type 0.0036 0.008 0.0109
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0067 0.0482 0.091
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0156 0.1636 0.1625
Entamoeba histolytica cell division protein kinase 2, putative 0.0099 0.0895 0.2314
Echinococcus granulosus serine:threonine protein kinase 0.0095 0.0843 0.1629
Entamoeba histolytica PH domain containing protein kinase, putative 0.0099 0.09 0.2326
Echinococcus multilocularis netrin receptor unc 5 0.0034 0.0055 0.0059
Leishmania major casein kinase, putative 0.009 0.0783 0.3046
Brugia malayi intracellular kinase 0.0107 0.1004 0.0993
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.2571 0.9448
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0198 0.2183 0.4294
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0482 0.173
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0265 0.0545
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0066 0.0477 0.3563
Brugia malayi RhoGAP domain containing protein 0.0036 0.008 0.0067
Echinococcus granulosus netrin receptor unc 5 0.0034 0.0055 0.0059
Giardia lamblia Kinase, NEK 0.0114 0.1087 0.3891
Schistosoma mansoni protein kinase 0.0368 0.4381 0.902
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0083 0.0697 0.1336
Trichomonas vaginalis AGC family protein kinase 0.024 0.272 1
Echinococcus granulosus protein kinase shaggy 0.0107 0.1004 0.1949
Echinococcus granulosus hypothetical protein 0.0103 0.0952 0.1845
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0069 0.0507 0.1823
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0311 0.3638 0.7191
Echinococcus granulosus NDR protein kinase 0.0129 0.1284 0.2505
Echinococcus granulosus cGMP dependent protein kinase 1 0.0112 0.107 0.2079
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0071 0.0533 0.101
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0169 0.1802 0.1791
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0099 0.0899 0.1738
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0042 0.0164 0.0275
Brugia malayi Egg laying defective protein 4 0.0112 0.107 0.1058
Leishmania major protein kinase, putative 0.0122 0.119 0.4631
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0106 0.0985 0.191
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0979 0.3566
Trichomonas vaginalis CMGC family protein kinase 0.0069 0.0507 0.1823
Brugia malayi putative serine/threonine kinase SADA gamma 0.0074 0.057 0.0558
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0091 0.0078
Plasmodium falciparum casein kinase 2, alpha subunit 0.0083 0.0689 0.5189
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0107 0.1004 0.0993
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0169 0.1801 0.3535
Entamoeba histolytica protein kinase, putative 0.0058 0.0365 0.0921
Echinococcus multilocularis unc 13 (munc13) 0.0037 0.0094 0.0136
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0783 0.1612
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0068 0.05 0.0488
Echinococcus granulosus tyrosine protein kinase HCK 0.0039 0.0126 0.0201
Trypanosoma cruzi Protein kinase B 0.0136 0.1382 0.5351
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0933 0.1922
Brugia malayi serine/threonine-protein kinase plk-2 0.0228 0.2571 0.2561
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0042 0.0164 0.0337
Schistosoma mansoni tyrosine kinase 0.0133 0.1335 0.2748
Loa Loa (eye worm) TK/EGFR protein kinase 0.0192 0.2102 0.2092
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0058 0.0365 0.0676
Leishmania major protein kinase, putative 0.0041 0.0142 0.0553
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0334 0.3941 0.7795
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0311 0.3638 0.7191
Echinococcus granulosus fibroblast growth factor receptor 4 0.0099 0.0899 0.1738
Entamoeba histolytica protein kinase, putative 0.0071 0.0533 0.1362
Trichomonas vaginalis AGC family protein kinase 0.0134 0.1352 0.4945
Brugia malayi diacylglycerol kinase 0.0036 0.008 0.0067
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0044 0.0186 0.0671
Brugia malayi MAP kinase sur-1 0.0069 0.0507 0.0495
Loa Loa (eye worm) hypothetical protein 0.0119 0.1152 0.1141
Schistosoma mansoni protein kinase 0.0071 0.0533 0.1097
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0044 0.0186 0.0173
Loa Loa (eye worm) hypothetical protein 0.0394 0.4721 0.4714
Trypanosoma cruzi casein kinase, putative 0.009 0.0783 0.3007
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0083 0.0697 0.2522
Leishmania major protein kinase, putative 0.0129 0.1281 0.4982
Brugia malayi Protein kinase domain containing protein 0.0179 0.194 0.1929
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0102 0.0933 0.3631
Brugia malayi Immunoglobulin I-set domain containing protein 0.0332 0.3909 0.3901
Onchocerca volvulus 0.0119 0.1152 0.3285
Plasmodium vivax protein kinase Crk2 0.0099 0.0895 0.678
Echinococcus multilocularis 0.0128 0.1275 0.2488
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.057 0.1174
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.028 0.3247 0.3238
Loa Loa (eye worm) hypothetical protein 0.0154 0.1615 0.1604
Brugia malayi serine/threonine-protein kinase PAK 7 0.0196 0.2148 0.2138
Echinococcus granulosus serine:threonine protein kinase N2 0.024 0.2718 0.5359
Brugia malayi Protein kinase domain containing protein 0.0099 0.0895 0.0883
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0147 0.152 0.2974
Schistosoma mansoni tyrosine kinase 0.0118 0.115 0.2367
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0044 0.0186 0.0173
Giardia lamblia Kinase, CAMK CAMKL 0.0074 0.057 0.1762
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0094 0.0831 0.3196
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0121 0.1183 0.2305
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0228 0.2571 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0058 0.0373 0.0693
Echinococcus multilocularis cyclin dependent kinase 1 0.0099 0.0895 0.1732
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0129 0.1281 0.4954
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0058 0.0373 0.0693
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0228 0.2571 0.5066
Brugia malayi ephrin receptor 1 precursor 0.004 0.0136 0.0123
Loa Loa (eye worm) hypothetical protein 0.0076 0.0605 0.0592
Onchocerca volvulus 0.0037 0.0094 0.0233
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.009 0.0783 0.0771
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0285 0.3301 0.3293
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0129 0.1284 0.2505
Brugia malayi Protein kinase c protein 2 0.0096 0.0861 0.0849
Loa Loa (eye worm) hypothetical protein 0.006 0.0389 0.0376
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0121 0.1183 0.2305
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0166 0.176 0.1749
Echinococcus granulosus tyrosine protein kinase Fyn 0.0058 0.0373 0.0693
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0895 0.3256
Echinococcus multilocularis serine threonine protein kinase 0.0164 0.1736 0.3406
Trypanosoma cruzi casein kinase, putative 0.009 0.0783 0.3007
Echinococcus granulosus activin receptor type 0.004 0.0131 0.021
Echinococcus multilocularis ephrin type A receptor 4 A 0.0069 0.051 0.0965
Brugia malayi Serine/threonine-protein kinase SULU 0.0187 0.2039 0.2029
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0299 0.3481 0.6878
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0136 0.1382 0.5351
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0096 0.0853 0.3101
Echinococcus multilocularis 0.0103 0.0952 0.1845
Loa Loa (eye worm) CAMK protein kinase 0.0037 0.0091 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Schistosoma mansoni serine/threonine kinase 0.0129 0.1284 0.2643
Trypanosoma cruzi Serine/threonine-protein kinase NEK16, putative 0.0041 0.0142 0.0501
Trichomonas vaginalis STE family protein kinase 0.0041 0.0142 0.0473
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0299 0.3481 0.6878
Leishmania major protein kinase, putative 0.004 0.0131 0.0509
Giardia lamblia Kinase, CMGC GSK 0.0107 0.1004 0.355
Echinococcus granulosus tyrosine kinase 0.0046 0.021 0.0368
Schistosoma mansoni unc-13 (munc13) 0.0037 0.0094 0.0193
Brugia malayi hypothetical protein 0.0048 0.0242 0.0229
Schistosoma mansoni tyrosine kinase 0.0166 0.1768 0.3639
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0033 0.0049 0.0048
Schistosoma mansoni tyrosine kinase 0.0033 0.0049 0.0101
Schistosoma mansoni tyrosine kinase 0.0041 0.0149 0.0307
Echinococcus multilocularis rac serine:threonine kinase 0.0136 0.1382 0.2701
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0183 0.1988 0.1978
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0058 0.0373 0.0693
Loa Loa (eye worm) hypothetical protein 0.0043 0.0179 0.0166
Echinococcus multilocularis nervana 2 0.0106 0.0985 0.191
Toxoplasma gondii NEK kinase 0.0041 0.0142 0.0485
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0069 0.0507 0.1929
Echinococcus multilocularis epidermal growth factor receptor 0.0192 0.2102 0.4134
Echinococcus granulosus mitogen activated protein kinase 11 0.0133 0.1341 0.2619
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Loa Loa (eye worm) TK protein kinase 0.0046 0.021 0.0197
Trichomonas vaginalis AGC family protein kinase 0.024 0.272 1
Schistosoma mansoni serine/threonine protein kinase 0.0137 0.1396 0.2875
Entamoeba histolytica protein kinase, putative 0.0068 0.05 0.1277
Plasmodium falciparum calcium-dependent protein kinase 3 0.0083 0.0697 0.5251
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.007 0.0518 0.1969
Brugia malayi Temporarily assigned gene name protein 59 0.011 0.1044 0.1032
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0097 0.0876 0.0864
Schistosoma mansoni hypothetical protein 0.0036 0.008 0.0164
Schistosoma mansoni vam6/vps39 related 0.0096 0.0853 0.1757
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0622 0.1281
Giardia lamblia Kinase, NEK 0.0114 0.1087 0.3891
Echinococcus multilocularis protein kinase shaggy 0.0107 0.1004 0.1949
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0129 0.1281 0.4954
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0831 0.1712
Entamoeba histolytica protein kinase, putative 0.0057 0.0361 0.0911
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0299 0.3481 0.3472
Loa Loa (eye worm) hypothetical protein 0.007 0.0518 0.0506
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0234 0.2652 0.2642
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0068 0.05 0.1797
Leishmania major protein kinase, putative,serine/threonine-protein kinase Nek1, putative 0.0041 0.0142 0.0553
Brugia malayi Tyrosine-protein kinase abl-1 0.0033 0.0049 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.2571 0.9448
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0099 0.0899 0.1738
Echinococcus granulosus twitchin 0.0076 0.0599 0.1143
Echinococcus granulosus tyrosine protein kinase Blk 0.0046 0.021 0.0368
Loa Loa (eye worm) hypothetical protein 0.0103 0.0952 0.094
Echinococcus granulosus cyclin dependent kinase 5 0.0099 0.0895 0.1732
Entamoeba histolytica protein kinase domain containing protein 0.004 0.0131 0.0306
Echinococcus multilocularis aurora kinase A 0.0122 0.119 0.2319
Trypanosoma brucei rac serine-threonine kinase, putative 0.024 0.272 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0058 0.0373 0.0693
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.0142 0.0473
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0083 0.0697 0.0684
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0129 0.1284 0.2505
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0831 0.1712
Brugia malayi Protein kinase domain containing protein 0.0311 0.3638 0.363
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0131 0.1314 0.2564
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0068 0.05 0.1843
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0162 0.1714 0.1703
Loa Loa (eye worm) hypothetical protein 0.0076 0.0605 0.0592
Toxoplasma gondii AGC kinase 0.0094 0.0831 0.3098
Entamoeba histolytica casein kinase 1, putative 0.009 0.0783 0.202
Echinococcus multilocularis expressed protein 0.0068 0.05 0.0946
Echinococcus multilocularis casein kinase ii subunit alpha 0.0083 0.0689 0.132
Echinococcus multilocularis RNA directed DNA polymerase 0.0034 0.0056 0.0061
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0058 0.0373 0.0693
Brugia malayi Protein kinase domain containing protein 0.024 0.272 0.271
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.1802 0.371
Entamoeba histolytica protein kinase, putative 0.0122 0.119 0.309
Loa Loa (eye worm) hypothetical protein 0.0041 0.0152 0.0139
Trypanosoma cruzi aurora B kinase, putative 0.0122 0.119 0.4601
Echinococcus granulosus serine:threonine protein kinase 3 0.0217 0.2422 0.477
Echinococcus multilocularis casein kinase I gamma 0.0179 0.194 0.3811
Loa Loa (eye worm) hypothetical protein 0.0094 0.0831 0.0819
Trichomonas vaginalis CK1 family protein kinase 0.009 0.0783 0.2841
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0368 0.4381 0.8669
Trichomonas vaginalis AGC family protein kinase 0.0129 0.1284 0.4692
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0107 0.1004 0.2068
Entamoeba histolytica casein kinase, putative 0.009 0.0783 0.202
Echinococcus granulosus casein kinase I alpha 0.009 0.0783 0.1508
Echinococcus multilocularis N chimaerin 0.0042 0.0164 0.0275
Entamoeba histolytica protein kinase, putative 0.024 0.272 0.7108
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0042 0.0164 0.0151
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0133 0.1341 0.5218
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0334 0.3941 0.3933
Echinococcus granulosus Rac GTPase activating protein 1 0.0036 0.008 0.0109
Toxoplasma gondii diacylglycerol kinase, putative 0.0036 0.008 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.152 0.3129
Entamoeba histolytica cell division protein kinase 2, putative 0.0099 0.0895 0.2314
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0058 0.0373 0.0693
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0131 0.1314 0.2564
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.05 0.103
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0173 0.1851 0.3633
Schistosoma mansoni protein kinase 0.0122 0.119 0.2451
Loa Loa (eye worm) thyroid receptor interactor 0.0074 0.0575 0.0562
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0068 0.0503 0.0951
Toxoplasma gondii histone kinase SNF1, putative 0.0074 0.057 0.2108
Echinococcus multilocularis casein kinase I delta 0.009 0.0783 0.1508
Schistosoma mansoni protein kinase 0.009 0.0783 0.1612
Echinococcus multilocularis protein kinase c epsilon type 0.0166 0.176 0.3453
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.2571 0.5293
Schistosoma mansoni tyrosine kinase 0.0058 0.0373 0.0769
Trypanosoma cruzi polo-like protein kinase, putative 0.0228 0.2571 1
Schistosoma mansoni tyrosine kinase 0.0133 0.1335 0.2748
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0083 0.0697 0.2587
Echinococcus granulosus tyrosine protein kinase Lyn 0.0084 0.0702 0.1347
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.1118 0.4081
Schistosoma mansoni serine/threonine protein kinase 0.0223 0.2504 0.5156
Schistosoma mansoni diacylglycerol kinase theta 0.0036 0.008 0.0164
Brugia malayi Fes/CIP4 homology domain containing protein 0.0074 0.0575 0.0562
Giardia lamblia Kinase, AGC AKT 0.0097 0.0876 0.3022
Schistosoma mansoni titin 0.0037 0.0091 0.0188
Onchocerca volvulus 0.004 0.0132 0.0341
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0099 0.0895 0.3341
Brugia malayi cell division control protein 2 homolog 0.0099 0.0895 0.0883
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0201 0.2214 0.4357
Brugia malayi Hr1 repeat family protein 0.024 0.2718 0.2708
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.1118 0.2303
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0689 0.2492
Entamoeba histolytica protein kinase, putative 0.0032 0.003 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0312 0.0643
Leishmania major protein kinase A catalytic subunit isoform 1 0.0094 0.0831 0.3234
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0066 0.0477 0.1756
Trichomonas vaginalis AGC family protein kinase 0.024 0.272 1
Echinococcus multilocularis epidermal growth factor receptor 0.0133 0.1335 0.2606
Onchocerca volvulus Serine\/threonine kinase homolog 0.0228 0.2571 0.7375
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0074 0.057 0.2218
Schistosoma mansoni protein kinase 0.0368 0.4381 0.902
Schistosoma mansoni protein kinase 0.0224 0.2511 0.517
Echinococcus multilocularis calcium dependent protein kinase 0.0058 0.0368 0.0682
Toxoplasma gondii aurora kinase 0.0122 0.119 0.446
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.1281 0.2637
Brugia malayi Protein kinase domain 0.0071 0.0533 0.052
Brugia malayi protein kinase C3,putative 0.0132 0.1325 0.1314
Entamoeba histolytica protein kinase, putative 0.0234 0.2652 0.6928
Echinococcus multilocularis dual specificity 0.0116 0.1118 0.2176
Loa Loa (eye worm) hypothetical protein 0.0074 0.057 0.0558
Plasmodium vivax tyrosine kinase-like protein, putative 0.0066 0.0477 0.3563
Toxoplasma gondii CMGC kinase, CK2 family 0.0083 0.0689 0.2557
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0204 0.0701
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.2571 0.9448
Echinococcus granulosus nervana 2 0.0106 0.0985 0.191
Trichomonas vaginalis STE family protein kinase 0.0071 0.0533 0.1916
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0069 0.0507 0.0495
Schistosoma mansoni tyrosine kinase 0.0099 0.0899 0.185
Echinococcus granulosus mitogen activated protein kinase 3 0.0069 0.0507 0.096
Schistosoma mansoni vesicular amine transporter 0.0041 0.0152 0.0313
Leishmania major protein kinase A catalytic subunit isoform 2 0.0094 0.0831 0.3234
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.194 0.3994
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0094 0.0831 0.1605
Echinococcus granulosus tyrosine protein kinase Fyn 0.0058 0.0373 0.0693
Echinococcus granulosus protein kinase c epsilon type 0.0166 0.176 0.3453
Brugia malayi hypothetical protein 0.0043 0.0179 0.0166
Loa Loa (eye worm) hypothetical protein 0.0041 0.0148 0.0135
Entamoeba histolytica protein kinase, putative 0.0039 0.0126 0.0295
Echinococcus multilocularis mitogen activated protein kinase 14 0.0133 0.1341 0.2619
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0041 0.0152 0.0313
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0094 0.0831 0.1605
Brugia malayi map kinase activated protein kinase protein 2 0.0334 0.3941 0.3933
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.006 0.0398 0.0386
Trichomonas vaginalis AGC family protein kinase 0.024 0.272 1
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0187 0.2039 0.4008
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.1004 0.366
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0094 0.0831 0.302
Echinococcus multilocularis cyclin dependent kinase 5 0.0099 0.0895 0.1732
Schistosoma mansoni protein kinase 0.0368 0.4381 0.902
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0102 0.0933 0.3397
Onchocerca volvulus Tyrosine kinase homolog 0.029 0.3375 0.9694
Echinococcus granulosus c src tyrosine kinase 0.0033 0.0049 0.0048
Entamoeba histolytica protein kinase, putative 0.0122 0.119 0.309
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0133 0.1341 0.5191
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0094 0.0831 0.1605
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0201 0.2214 0.4357
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.2571 0.9448
Echinococcus multilocularis cyclin dependent kinase 1 0.0099 0.0895 0.1732
Loa Loa (eye worm) AGC/PKN protein kinase 0.024 0.2718 0.2708
Brugia malayi Stress-activated protein kinase jnk-1 0.0223 0.2504 0.2494
Loa Loa (eye worm) AGC/AKT protein kinase 0.024 0.272 0.271
Onchocerca volvulus 0.0163 0.1728 0.4945
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0129 0.1281 0.4802
Echinococcus multilocularis Immunoglobulin 0.0041 0.0152 0.0252
Schistosoma mansoni hypothetical protein 0.0096 0.0853 0.1757
Echinococcus multilocularis tyrosine protein kinase Srms 0.0046 0.021 0.0368
Schistosoma mansoni hypothetical protein 0.0052 0.0293 0.0604
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.1636 0.3369
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Loa Loa (eye worm) hypothetical protein 0.0043 0.0179 0.0166
Entamoeba histolytica p21-activated kinase 0.0076 0.0601 0.1542
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0042 0.0164 0.0337
Trypanosoma cruzi casein kinase II, putative 0.0083 0.0689 0.2638
Trypanosoma brucei protein kinase, putative 0.0107 0.1004 0.366
Loa Loa (eye worm) hypothetical protein 0.0052 0.0293 0.0281
Echinococcus granulosus Immunoglobulin 0.0041 0.0152 0.0252
Entamoeba histolytica protein kinase, putative 0.0083 0.0697 0.1793
Trypanosoma cruzi polo-like protein kinase, putative 0.0228 0.2571 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0228 0.2571 0.6716
Brugia malayi Casein kinase II, alpha chain 0.0083 0.0689 0.0676
Trypanosoma cruzi cdc2-related kinase 3 0.0099 0.0895 0.3446
Echinococcus multilocularis raf serine:threonine protein kinase 0.005 0.0265 0.0477
Schistosoma mansoni protein kinase 0.004 0.0131 0.0269
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0094 0.0831 0.302
Schistosoma mansoni nephrin 0.0053 0.0297 0.0612
Plasmodium falciparum serine/threonine protein kinase, putative 0.0122 0.119 0.9052
Brugia malayi protein kinase C II. 0.0166 0.176 0.1749
Entamoeba histolytica protein kinase domain containing protein 0.0107 0.1004 0.2601
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0058 0.0373 0.0693
Schistosoma mansoni rap gtpase-activating protein 0.0096 0.0853 0.1757
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.017 0.1822 0.1812
Brugia malayi C1-like domain containing protein 0.0183 0.1988 0.1978
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0482 0.173
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0697 0.2522
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0102 0.0933 0.3595
Entamoeba histolytica protein kinase , putative 0.0122 0.119 0.309
Loa Loa (eye worm) hypothetical protein 0.0041 0.0152 0.0139
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0096 0.0853 0.1757
Entamoeba histolytica protein kinase, putative 0.0102 0.0933 0.2414
Leishmania major casein kinase II, putative 0.0083 0.0689 0.2679
Schistosoma mansoni serine/threonine protein kinase 0.017 0.1822 0.3752
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0037 0.0091 0.0078
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0137 0.1393 0.1381
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0107 0.1004 0.0993
Echinococcus granulosus myotubularin protein 13 0.0041 0.0148 0.0245
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.2571 0.9448
Trypanosoma cruzi casein kinase, putative 0.009 0.0783 0.3007
Toxoplasma gondii casein kinase I 0.009 0.0783 0.2915
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0895 0.3256
Trichomonas vaginalis AGC family protein kinase 0.024 0.272 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0136 0.1382 0.3593
Onchocerca volvulus 0.0037 0.0091 0.0226
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0121 0.1182 0.2302
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.057 0.2054
Trypanosoma cruzi casein kinase, putative 0.009 0.0783 0.3007
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.1284 0.2643
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0099 0.0895 0.3483
Loa Loa (eye worm) hypothetical protein 0.0122 0.1197 0.1185
Brugia malayi Protein kinase domain containing protein 0.0299 0.3481 0.3472
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.0142 0.0473
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0156 0.1636 0.3207
Echinococcus multilocularis Rac GTPase activating protein 1 0.0036 0.008 0.0109
Trichomonas vaginalis AGC family protein kinase 0.0122 0.119 0.4347
Brugia malayi Furin-like cysteine rich region family protein 0.0192 0.2102 0.2092
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.021 0.0368
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0697 0.1434
Entamoeba histolytica hypothetical protein 0.0102 0.0933 0.2414
Echinococcus multilocularis mitogen activated protein kinase 11 0.0133 0.1341 0.2619
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0112 0.107 0.2079
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0058 0.0373 0.0693
Brugia malayi Immunoglobulin I-set domain containing protein 0.0034 0.0055 0.0042
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.1281 0.468
Brugia malayi STE20-like kinase MST 0.0217 0.2422 0.2412
Loa Loa (eye worm) AGC/PKG protein kinase 0.0112 0.107 0.1058
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.2571 0.9448
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0131 0.1314 0.5083
Giardia lamblia Kinase, STE STE20 0.007 0.0518 0.1546
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0012 0.0025
Brugia malayi RhoGEF domain containing protein 0.0036 0.008 0.0067
Schistosoma mansoni ephrin receptor 0.0069 0.051 0.1051
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0126 0.1249 0.1238
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0133 0.1341 0.5191
Loa Loa (eye worm) raf kinase 0.0036 0.008 0.0067
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0071 0.0533 0.101
Leishmania major folate/biopterin transporter, putative 0.0031 0.0014 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.2571 0.9448
Brugia malayi probable protein kinase 0.0224 0.2511 0.2501
Brugia malayi Protein kinase domain containing protein 0.0067 0.0482 0.047
Schistosoma mansoni serine/threonine-protein kinase 0.0136 0.1382 0.2846
Schistosoma mansoni netrin receptor unc5 0.0034 0.0055 0.0113
Onchocerca volvulus 0.0275 0.3178 0.9125
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.009 0.0783 0.0771
Echinococcus multilocularis c src tyrosine kinase 0.0033 0.0049 0.0048
Trichomonas vaginalis AGC family protein kinase 0.024 0.272 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0083 0.0697 0.1336
Trypanosoma brucei cdc2-related kinase 3 0.0099 0.0895 0.3256
Trypanosoma brucei Casein kinase II 0.0083 0.0689 0.2492
Echinococcus multilocularis serine:threonine protein kinase 0.0095 0.0843 0.1629
Leishmania major serine/threonine-protein kinase a, putative 0.0031 0.0014 0.0056
Echinococcus granulosus dual specificity 0.0116 0.1118 0.2176
Schistosoma mansoni diacylglycerol kinase theta 0.0036 0.008 0.0164
Echinococcus multilocularis mitogen activated protein kinase 3 0.0069 0.0507 0.096
Echinococcus granulosus protein kinase C gamma type 0.0164 0.1736 0.3406
Loa Loa (eye worm) hypothetical protein 0.0034 0.0056 0.0043
Entamoeba histolytica protein kinase, putative 0.0052 0.0293 0.0732
Echinococcus granulosus cGMP dependent protein kinase 1 0.0112 0.107 0.2079
Brugia malayi p70 ribosomal S6 kinase beta 0.0234 0.2652 0.2642
Loa Loa (eye worm) hypothetical protein 0.0096 0.0853 0.0841
Plasmodium falciparum protein kinase, putative 0.004 0.0131 0.0896
Trichomonas vaginalis STE family protein kinase 0.0071 0.0533 0.1916
Schistosoma mansoni serine/threonine protein kinase 0.024 0.2718 0.5596
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0083 0.0697 0.5251
Loa Loa (eye worm) AGC/PKA protein kinase 0.0094 0.0831 0.0819
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0067
Schistosoma mansoni protein kinase 0.0052 0.0293 0.0603
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0142 0.0293
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0156 0.1636 0.1625
Trypanosoma cruzi NIMA-related kinase, putative 0.0041 0.0142 0.0501
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0831 0.1712
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0122 0.119 0.2319
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.009 0.0783 0.0771
Echinococcus multilocularis Glutaredoxin protein 5 0.0106 0.0985 0.191
Schistosoma mansoni serine/threonine-protein kinase 0.0136 0.1382 0.2846
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0069 0.0507 0.1929
Echinococcus granulosus rho-associated protein kinase 1 0.0275 0.3178 0.6274
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0198 0.2181 0.429

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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