Detailed information for compound 947746

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 428.308 | Formula: C15H16N4O11
  • H donors: 1 H acceptors: 7 LogP: -0.98 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)O[C@@H]1[C@H](OC(=O)C)[C@H](O[C@H]1n1c(=O)[nH]c(=O)c2c1no[n+]2[O-])COC(=O)C
  • InChi: 1S/C15H16N4O11/c1-5(20)26-4-8-10(27-6(2)21)11(28-7(3)22)14(29-8)18-12-9(19(25)30-17-12)13(23)16-15(18)24/h8,10-11,14H,4H2,1-3H3,(H,16,23,24)/t8-,10-,11-,14-/m1/s1
  • InChiKey: IKTHVIMWXFDOLY-IDTAVKCVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tubulin gamma 1 chain 0.0181 0.062 0.074
Plasmodium vivax multidomain scavenger receptor, putative 0.0172 0.0586 0.0685
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0079 0.0222 0.0214
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0185 0.0227
Echinococcus granulosus sterol regulatory element binding protein 0.0056 0.0134 0.016
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0022 0.0002 0.0002
Onchocerca volvulus Peroxidase homolog 0.0078 0.0218 0.0538
Entamoeba histolytica protein kinase domain containing protein 0.0257 0.0916 0.2228
Echinococcus granulosus tyrosine kinase 0.0046 0.0097 0.0115
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0076 0.0212 0.0047
Schistosoma mansoni tubulin subunit beta 0.0321 0.1168 0.1393
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0076 0.0212 0.0207
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0008 0.0009
Entamoeba histolytica protein kinase, putative 0.0043 0.0082 0.0188
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0076 0.0212 0.0307
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0185 0.022
Leishmania major alpha tubulin 0.0259 0.0926 0.1099
Loa Loa (eye worm) hypothetical protein 0.003 0.0033 0.0039
Leishmania major hypothetical protein, conserved 0.0206 0.0716 0.0848
Loa Loa (eye worm) alpha-tubulin 0.0259 0.0926 0.1143
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0089 0.0263 0.0323
Trichomonas vaginalis tubulin epsilon chain, putative 0.0079 0.0222 0.0214
Brugia malayi Peroxidasin 0.0117 0.0371 0.0459
Giardia lamblia Kinase, CMGC GSK 0.0257 0.0916 0.6291
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0002 0.0003
Schistosoma mansoni tyrosine kinase 0.0746 0.282 0.3364
Schistosoma mansoni alpha tubulin 0.0259 0.0926 0.1105
Onchocerca volvulus Dual oxidase homolog 0.0078 0.0218 0.0538
Leishmania major alpha tubulin 0.0259 0.0926 0.1099
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0076 0.0212 0.0207
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0181 0.062 0.0765
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0257 0.0916 0.1764
Trichomonas vaginalis tubulin alpha chain, putative 0.0102 0.0314 0.0307
Loa Loa (eye worm) animal heme peroxidase 0.0095 0.0285 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.2589 1 1
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0076 0.0212 0.0397
Schistosoma mansoni netrin receptor unc5 0.0036 0.0056 0.0067
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0096 0.0291 0.0341
Entamoeba histolytica cell division protein kinase 2, putative 0.0096 0.0291 0.0698
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0295 0.1063 0.1268
Echinococcus multilocularis tubulin alpha 3 chain 0.0259 0.0926 0.1105
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0027 0.0034
Echinococcus multilocularis Immunoglobulin 0.003 0.0033 0.0039
Echinococcus granulosus roundabout 2 0.0039 0.0069 0.0082
Schistosoma mansoni peroxidasin 0.0078 0.0218 0.026
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0267
Trypanosoma brucei alpha tubulin, putative 0.0102 0.0314 0.0158
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0284 0.0683
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0295 0.1063 0.124
Leishmania major carbamoyl-phosphate synthase, putative 0.0187 0.0644 0.0763
Giardia lamblia Alpha-tubulin 0.0259 0.0926 0.6373
Schistosoma mansoni septate junction protein 0.0022 0.0002 0.0002
Giardia lamblia Delta tubulin 0.0079 0.0222 0.0477
Loa Loa (eye worm) hypothetical protein 0.0056 0.0134 0.0164
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0295 0.1063 0.2049
Schistosoma mansoni patched 1 0.0056 0.0134 0.016
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0033 0.0041
Giardia lamblia Beta tubulin 0.0321 0.1168 0.8394
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0038 0.0082
Plasmodium vivax tubulin alpha chain, putative 0.0259 0.0926 0.1266
Brugia malayi Immunoglobulin domain containing protein 0.0022 0.0002 0.0002
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0039 0.0069 0.0161
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0295 0.1063 0.1329
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0291 0.0283
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0828 0.3141 1
Echinococcus granulosus tyrosine protein kinase otk 0.0039 0.0069 0.0082
Schistosoma mansoni hypothetical protein 0.0175 0.0597 0.0712
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0284 0.0277
Echinococcus multilocularis tubulin alpha 3 chain 0.0259 0.0926 0.1105
Brugia malayi Doublecortin family protein 0.0172 0.0586 0.0725
Loa Loa (eye worm) hypothetical protein 0.0157 0.0527 0.065
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0069 0.0185 0.0188
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0218 0.0267
Echinococcus granulosus epidermal growth factor receptor 0.0522 0.1949 0.2325
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0284 0.0277
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0291 0.0283
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0218 0.0269
Echinococcus granulosus roundabout 2 0.007 0.0187 0.0223
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0076 0.0212 0.0262
Brugia malayi Cell division protein ftsZ 0.0079 0.0222 0.0274
Echinococcus multilocularis neuroglian 0.0039 0.0069 0.0082
Brugia malayi hypothetical protein 0.0022 0.0002 0.0002
Schistosoma mansoni vesicular amine transporter 0.003 0.0033 0.0039
Trichomonas vaginalis tubulin, putative 0.0079 0.0222 0.0214
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0828 0.3141 0.6084
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0083
Loa Loa (eye worm) hypothetical protein 0.003 0.0033 0.0039
Echinococcus granulosus lachesin 0.0039 0.0069 0.0082
Loa Loa (eye worm) SRC-1 0.005 0.011 0.0135
Loa Loa (eye worm) tubulin alpha 2 0.0181 0.062 0.0765
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0116 0.0143
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0291 0.0347
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0295 0.1063 0.2049
Echinococcus multilocularis tubulin alpha 1C chain 0.0259 0.0926 0.1105
Echinococcus granulosus jun protein 0.0095 0.0287 0.0343
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0032
Entamoeba histolytica hypothetical protein 0.0039 0.0068 0.0154
Brugia malayi hypothetical protein 0.0172 0.0586 0.0725
Entamoeba histolytica protein kinase domain containing protein 0.0257 0.0916 0.2228
Schistosoma mansoni hypothetical protein 0.0022 0.0002 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0284 0.0277
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0002 0.0003
Onchocerca volvulus Peroxidase homolog 0.0078 0.0218 0.0538
Schistosoma mansoni hypothetical protein 0.0039 0.0068 0.0082
Echinococcus granulosus Immunoglobulin 0.003 0.0033 0.0039
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0005
Onchocerca volvulus Chorion peroxidase homolog 0.0078 0.0218 0.0538
Giardia lamblia Kinase, CMGC CDK 0.0096 0.0291 0.1057
Schistosoma mansoni septate junction protein 0.0022 0.0002 0.0002
Brugia malayi Tubulin alpha-2 chain 0.0259 0.0926 0.1145
Echinococcus granulosus cyclin dependent kinase 1 0.0096 0.0291 0.0347
Loa Loa (eye worm) hypothetical protein 0.007 0.0187 0.0229
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0828 0.3141 0.3747
Trypanosoma brucei zeta tubulin 0.0079 0.0222 0.0045
Loa Loa (eye worm) beta-tubulin 0.0321 0.1168 0.1442
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Leishmania major alpha tubulin 0.0259 0.0926 0.1099
Echinococcus granulosus insulin receptor 0.0723 0.2731 0.3258
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0039 0.0069 0.0082
Trypanosoma brucei cdc2-related kinase 1 0.0096 0.0291 0.013
Echinococcus granulosus low density lipoprotein receptor ldl 0.0022 0.0002 0.0002
Brugia malayi Tubulin alpha chain 0.0259 0.0926 0.1145
Trichomonas vaginalis tubulin gamma chain, putative 0.0321 0.1168 0.1161
Echinococcus granulosus tubulin alpha chain 0.0259 0.0926 0.1105
Schistosoma mansoni hypothetical protein 0.0078 0.022 0.0263
Schistosoma mansoni septate junction protein 0.0039 0.0069 0.0082
Loa Loa (eye worm) TK/EGFR protein kinase 0.0746 0.282 0.3486
Loa Loa (eye worm) TK protein kinase 0.0043 0.0082 0.01
Echinococcus multilocularis peroxisome assembly protein 26 0.0259 0.0926 0.1105
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0828 0.3141 0.3137
Onchocerca volvulus Putative sulfate transporter 0.0434 0.1605 0.4046
Mycobacterium ulcerans carbonic anhydrase 0.1073 0.4094 0.4091
Plasmodium falciparum tubulin epsilon chain, putative 0.0181 0.062 0.0986
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0105 0.0097
Echinococcus granulosus netrin receptor unc 5 0.0036 0.0056 0.0067
Schistosoma mansoni pyruvate carboxylase 0.0828 0.3141 0.3747
Leishmania major alpha tubulin 0.0259 0.0926 0.1099
Mycobacterium ulcerans hypothetical protein 0.0024 0.0008 0.0002
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0181 0.062 0.0613
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0068 0.0082
Entamoeba histolytica hypothetical protein 0.0039 0.0068 0.0154
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Echinococcus multilocularis tubulin delta chain 0.0079 0.0222 0.0264
Echinococcus multilocularis tubulin alpha 1C chain 0.0259 0.0926 0.1105
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0267
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0083
Echinococcus granulosus Polycystic kidney disease protein 0.0172 0.0586 0.0699
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0187 0.0644 0.0769
Schistosoma mansoni tyrosine kinase 0.0723 0.2731 0.3258
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0126 0.0405 0.0772
Echinococcus granulosus epidermal growth factor receptor 0.0746 0.282 0.3364
Trypanosoma cruzi beta tubulin, putative 0.0321 0.1168 0.2252
Echinococcus multilocularis tyrosine protein kinase Srms 0.0046 0.0097 0.0115
Echinococcus granulosus tyrosine protein kinase Src42A 0.0032 0.004 0.0048
Echinococcus multilocularis Niemann Pick C1 protein 0.0056 0.0134 0.016
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0181 0.062 0.071
Plasmodium falciparum protein kinase 5 0.0096 0.0291 0.0438
Echinococcus multilocularis roundabout 2 0.007 0.0187 0.0223
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0187 0.0644 0.1236
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0185 0.022
Trichomonas vaginalis CMGC family protein kinase 0.0257 0.0916 0.0909
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0828 0.3141 0.3941
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0076 0.0212 0.0253
Schistosoma mansoni Neurotrimin precursor (hNT) 0.003 0.0033 0.0039
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0083
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0076 0.0212 0.0506
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0172 0.0586 0.0723
Onchocerca volvulus 0.0172 0.0586 0.1469
Trichomonas vaginalis tubulin epsilon chain, putative 0.0321 0.1168 0.1161
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.1168 0.1393
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0136 0.0446 0.0441
Loa Loa (eye worm) TK/INSR protein kinase 0.0723 0.2731 0.3376
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0134 0.0126
Onchocerca volvulus 0.0156 0.0523 0.1309
Brugia malayi MH2 domain containing protein 0.0123 0.0395 0.0489
Leishmania major alpha tubulin 0.0259 0.0926 0.1099
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Brugia malayi Immunoglobulin domain containing protein 0.0022 0.0002 0.0002
Echinococcus granulosus tubulin alpha 1C chain 0.0259 0.0926 0.1105
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0105 0.0097
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0076 0.0212 0.0397
Echinococcus granulosus RUN 0.0172 0.0586 0.0699
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.011 0.0134
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Echinococcus multilocularis tubulin epsilon chain 0.0181 0.062 0.074
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0295 0.1063 0.1058
Loa Loa (eye worm) hypothetical protein 0.0076 0.0212 0.026
Brugia malayi Fibronectin type III domain containing protein 0.003 0.0033 0.0041
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0295 0.1063 0.1058
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0022 0.0002 0.0002
Brugia malayi protein-tyrosine kinase 0.0046 0.0097 0.0119
Schistosoma mansoni hypothetical protein 0.0175 0.0597 0.0712
Trypanosoma brucei zeta tubulin, putative 0.0079 0.0222 0.0045
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0126 0.0405 0.0772
Echinococcus granulosus peroxidasin 0.0117 0.0371 0.0443
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0295 0.1063 0.1268
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0056 0.0134 0.0164
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0022 0.0002 0.0002
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0039 0.0069 0.0082
Loa Loa (eye worm) tubulin alpha chain 0.0259 0.0926 0.1143
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0008 0.0002
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.0076 0.0212 0.0103
Giardia lamblia Alpha-tubulin 0.0259 0.0926 0.6373
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0002 0.0003
Onchocerca volvulus 0.0434 0.1605 0.4046
Brugia malayi basement membrane proteoglycan precursor 0.0022 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0136 0.0446 0.055
Echinococcus multilocularis tubulin alpha chain 0.0259 0.0926 0.1105
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0076 0.0212 0.0262
Toxoplasma gondii alpha tubulin TUBA1 0.0259 0.0926 0.1076
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0076 0.0212 0.0221
Trypanosoma cruzi tubulin delta chain 0.0079 0.0222 0.0415
Echinococcus granulosus alpha tubulin 0.0259 0.0926 0.1105
Schistosoma mansoni kinase 0.005 0.011 0.0131
Giardia lamblia Gamma tubulin 0.0181 0.062 0.3814
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0136 0.0446 0.0319
Schistosoma mansoni carbonic anhydrase 0.0029 0.0027 0.0032
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0032 0.0039 0.0047
Schistosoma mansoni lipoxygenase 0.0312 0.1131 0.1349
Echinococcus granulosus expressed protein 0.0361 0.132 0.1575
Onchocerca volvulus 0.1006 0.3835 0.9687
Echinococcus multilocularis tyrosine protein kinase Blk 0.0046 0.0097 0.0115
Trypanosoma cruzi zeta tubulin, putative 0.0079 0.0222 0.0415
Entamoeba histolytica hypothetical protein 0.0039 0.0068 0.0154
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0257 0.0916 0.1093
Loa Loa (eye worm) tubulin alpha 2 0.0181 0.062 0.0765
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0622 0.2338 0.2789
Trypanosoma cruzi zeta tubulin, putative 0.0079 0.0222 0.0415
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0723 0.2731 0.3258
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0064 0.0164 0.0157
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.011 0.0132
Echinococcus granulosus geminin 0.0175 0.0597 0.0712
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0056 0.007
Echinococcus multilocularis Polycystic kidney disease protein 0.0172 0.0586 0.0699
Trypanosoma brucei carbonic anhydrase-like protein 0.0126 0.0405 0.0269
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0076 0.0212 0.0397
Schistosoma mansoni carbonic anhydrase 0.1073 0.4094 0.4884
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.011 0.0132
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0076 0.0212 0.0397
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0284 0.0277
Plasmodium vivax tubulin beta chain, putative 0.0321 0.1168 0.1678
Loa Loa (eye worm) TK/ROR protein kinase 0.0032 0.0039 0.0047
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.011 0.0132
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0295 0.1063 0.1058
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0069 0.0185 0.0262
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.2174 0.8383 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0069 0.0086
Loa Loa (eye worm) hypothetical protein 0.003 0.0033 0.0039
Trypanosoma brucei polo-like protein kinase 0.0095 0.0284 0.0122
Loa Loa (eye worm) hypothetical protein 0.003 0.0033 0.0039
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0076 0.0212 0.0247
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0068 0.0082
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0267
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0076 0.0212 0.026
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0076 0.0212 0.0307
Echinococcus granulosus tar DNA binding protein 0.0069 0.0185 0.022
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.2174 0.8383 1
Echinococcus multilocularis lachesin 0.0039 0.0069 0.0082
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0291 0.0283
Echinococcus multilocularis tubulin alpha chain 0.0259 0.0926 0.1105
Toxoplasma gondii alpha-tubulin I, putative 0.0259 0.0926 0.1076
Echinococcus granulosus tubulin subunit TubB 0.0259 0.0926 0.1105
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0267
Echinococcus granulosus tubulin beta 1 chain 0.0321 0.1168 0.1393
Schistosoma mansoni titin 0.0039 0.0069 0.0082
Echinococcus granulosus tubulin alpha chain 0.0259 0.0926 0.1105
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0027 0.0032
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.032 0.1163 0.1439
Echinococcus granulosus tubulin alpha 3 chain 0.0259 0.0926 0.1105
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0185 0.022
Trypanosoma cruzi tubulin delta chain 0.0079 0.0222 0.0415
Echinococcus multilocularis tyrosine protein kinase otk 0.0039 0.0069 0.0082
Onchocerca volvulus Peroxidasin homolog 0.0095 0.0285 0.0708
Schistosoma mansoni hypothetical protein 0.0035 0.0053 0.0063
Leishmania major epsilon tubulin, putative 0.0181 0.062 0.0734
Echinococcus granulosus tyrosine protein kinase Blk 0.0046 0.0097 0.0115
Schistosoma mansoni hypothetical protein 0.0022 0.0002 0.0002
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0828 0.3141 0.3747
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0076 0.0212 0.0253
Chlamydia trachomatis biotin carboxylase 0.0752 0.2844 1
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0136 0.0446 0.0532
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0136 0.0446 0.0526
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.1168 0.1393
Mycobacterium leprae cell division protein FtsZ 0.0079 0.0222 0.0529
Loa Loa (eye worm) hypothetical protein 0.0259 0.0926 0.1143
Schistosoma mansoni tubulin subunit delta 0.0079 0.0222 0.0264
Schistosoma mansoni tubulin subunit gamma 0.0181 0.062 0.074
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.011 0.0132
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0076 0.0212 0.026
Onchocerca volvulus 0.0078 0.0218 0.0538
Plasmodium vivax glycogen synthase kinase 3, putative 0.0257 0.0916 0.1249
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0295 0.1063 0.1058
Brugia malayi hypothetical protein 0.0072 0.0196 0.0242
Echinococcus granulosus tyrosine protein kinase Src64B 0.005 0.011 0.0132
Schistosoma mansoni polycystin 1-related 0.0172 0.0586 0.0699
Echinococcus multilocularis geminin 0.0175 0.0597 0.0712
Echinococcus multilocularis carbonic anhydrase II 0.0126 0.0405 0.0484
Mycobacterium ulcerans hypothetical protein 0.0076 0.0212 0.0207
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0501 0.1867 0.234
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0222 0.0214
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0076 0.0212 0.0247
Trypanosoma cruzi cdc2-related kinase 3 0.0096 0.0291 0.055
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.2174 0.8383 1
Echinococcus multilocularis jun protein 0.0095 0.0287 0.0343
Echinococcus multilocularis Tubulin alpha 1 chain 0.0259 0.0926 0.1105
Echinococcus granulosus carbonic anhydrase 0.0029 0.0027 0.0032
Loa Loa (eye worm) RNA binding protein 0.0069 0.0185 0.0227
Brugia malayi SRC-1 0.005 0.011 0.0137
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0218 0.0269
Echinococcus granulosus lipoxygenase domain containing protein 0.0172 0.0586 0.0699
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0267
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0039 0.0069 0.0082
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0022 0.0002 0.0002
Plasmodium vivax protein kinase Crk2 0.0096 0.0291 0.0181
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Schistosoma mansoni basigin related 0.0022 0.0002 0.0002
Brugia malayi Tubulin gamma chain 0.0181 0.062 0.0767
Giardia lamblia Kinase, PLK 0.0095 0.0284 0.1004
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0083
Trichomonas vaginalis tubulin beta chain, putative 0.0259 0.0926 0.0919
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1573 0.6043 1
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Loa Loa (eye worm) hypothetical protein 0.0117 0.0371 0.0457
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0076 0.0212 0.0221
Giardia lamblia Beta tubulin 0.0321 0.1168 0.8394
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0295 0.1063 0.2586
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0046 0.0097 0.0115
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0267
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0022 0.0002 0.0002
Schistosoma mansoni tubulin subunit alpha 0.0079 0.0222 0.0264
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0002 0.0003
Echinococcus multilocularis tubulin gamma 1 chain 0.0181 0.062 0.074
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0828 0.3141 0.3606
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0284 0.0537
Schistosoma mansoni neuroglian 0.0039 0.0069 0.0082
Brugia malayi Animal haem peroxidase family protein 0.0095 0.0285 0.0353
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0284 0.0537
Loa Loa (eye worm) doublecortin family protein 0.0172 0.0586 0.0723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.011 0.0131
Echinococcus granulosus tubulin alpha 0.0181 0.062 0.074
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0222 0.0214
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0027 0.0032
Loa Loa (eye worm) tubulin beta-1 chain 0.0321 0.1168 0.1442
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1573 0.6043 1
Entamoeba histolytica carbonic anhydrase, putative 0.1073 0.4094 1
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0076 0.0212 0.0253
Schistosoma mansoni jun-related protein 0.0078 0.022 0.0263
Loa Loa (eye worm) hypothetical protein 0.007 0.0187 0.0229
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0257 0.0916 0.1064
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.011 0.0136
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0032
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.2174 0.8383 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0095 0.0287 0.0343
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0828 0.3141 0.7668
Trypanosoma brucei beta tubulin 0.0181 0.062 0.0531
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.1168 0.1393
Echinococcus granulosus neuroglian 0.0039 0.0069 0.0082
Brugia malayi bZIP transcription factor family protein 0.0095 0.0287 0.0355
Echinococcus multilocularis 0.0223 0.0784 0.0935
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.1168 0.1393
Entamoeba histolytica hypothetical protein 0.0039 0.0068 0.0154
Loa Loa (eye worm) hypothetical protein 0.0076 0.0212 0.026
Schistosoma mansoni tubulin subunit alpha 0.0259 0.0926 0.1105
Brugia malayi Blistered cuticle protein 3 0.0078 0.0218 0.0269
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.2066 0.7962 1
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0136 0.0446 0.0532
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0008 0.0002
Echinococcus multilocularis lipoxygenase domain containing protein 0.0172 0.0586 0.0699
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0032 0.004 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0185 0.022
Echinococcus granulosus tubulin alpha 1C chain 0.0259 0.0926 0.1105
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.003 0.0033 0.0039
Echinococcus granulosus tubulin epsilon chain 0.0181 0.062 0.074
Brugia malayi Immunoglobulin domain containing protein 0.0022 0.0002 0.0002
Giardia lamblia Kinase, CMGC CDK 0.0096 0.0291 0.1057
Brugia malayi hypothetical protein 0.0172 0.0586 0.0725
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.011 0.0131
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0076 0.0212 0.0397
Echinococcus granulosus Biotin lipoyl attachment 0.0076 0.0212 0.0253
Echinococcus multilocularis tubulin subunit beta 0.0321 0.1168 0.1393
Trypanosoma brucei epsilon tubulin 0.0181 0.062 0.0531
Plasmodium vivax delta tubulin, putative 0.0079 0.0222 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0284 0.0277
Brugia malayi hypothetical protein 0.0078 0.0218 0.0269
Schistosoma mansoni tubulin subunit beta 0.0321 0.1168 0.1393
Echinococcus granulosus Tubulin alpha 1 chain 0.0259 0.0926 0.1105
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0284 0.0352
Echinococcus multilocularis sterol regulatory element binding protein 0.0056 0.0134 0.016
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.055 0.2056 0.2577
Echinococcus multilocularis Tubulin alpha 1 chain 0.0259 0.0926 0.1105
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0069 0.0086
Echinococcus multilocularis tubulin beta 1 chain 0.0321 0.1168 0.1393
Plasmodium vivax tubulin gamma chain, putative 0.0181 0.062 0.0744
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0056 0.0134 0.016
Trichomonas vaginalis tubulin epsilon chain, putative 0.0259 0.0926 0.0919
Loa Loa (eye worm) tubulin gamma chain 0.0181 0.062 0.0765
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0828 0.3141 0.3743
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0257 0.0916 0.1093
Onchocerca volvulus Tyrosine kinase homolog 0.1038 0.3958 1
Brugia malayi Prion-like- 0.0039 0.0069 0.0086
Schistosoma mansoni tyrosine kinase 0.0508 0.1893 0.2258
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0052 0.0119 0.0142
Trichomonas vaginalis tubulin gamma chain, putative 0.0079 0.0222 0.0214
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0284 0.0277
Onchocerca volvulus Peroxidasin homolog 0.0095 0.0285 0.0708
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0039 0.0069 0.0082
Echinococcus granulosus tubulin alpha chain 0.0259 0.0926 0.1105
Entamoeba histolytica cell division protein kinase 2, putative 0.0096 0.0291 0.0698
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0005 0.0007
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0022 0.0002 0.0002
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1073 0.4094 1
Echinococcus granulosus tubulin alpha chain 0.0259 0.0926 0.1105
Echinococcus multilocularis tyrosine protein kinase Src42A 0.005 0.011 0.0132
Schistosoma mansoni cell adhesion molecule 0.0039 0.0069 0.0082
Echinococcus granulosus defective proboscis extension response 0.003 0.0033 0.0039
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0295 0.1063 0.2905
Echinococcus multilocularis insulin receptor 0.0723 0.2731 0.3258
Loa Loa (eye worm) hypothetical protein 0.0181 0.062 0.0765
Trichomonas vaginalis tubulin beta chain, putative 0.0259 0.0926 0.0919
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0284 0.0706
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0022 0.0002 0.0002
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0029 0.0027 0.0032
Trypanosoma cruzi epsilon tubulin, putative 0.0181 0.062 0.119
Brugia malayi Tubulin beta chain 0.0079 0.0222 0.0274
Onchocerca volvulus 0.0072 0.0196 0.0482
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0284 0.0277
Echinococcus granulosus Tubulin alpha 1 chain 0.0259 0.0926 0.1105
Echinococcus granulosus twitchin 0.0051 0.0115 0.0137
Echinococcus granulosus tubulin subunit beta 0.0321 0.1168 0.1393
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0069 0.0082
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0116 0.0143
Brugia malayi intracellular kinase 0.0257 0.0916 0.1133
Schistosoma mansoni cell adhesion molecule 0.0052 0.0119 0.0142
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0005
Entamoeba histolytica tubulin alpha-1 chain 0.0259 0.0926 0.2252
Trypanosoma brucei epsilon tubulin 0.0181 0.062 0.0531
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0079 0.0222 0.0233
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0136 0.0446 0.0852
Loa Loa (eye worm) tubulin alpha chain 0.0259 0.0926 0.1143
Schistosoma mansoni roundabout 0.0039 0.0069 0.0082
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0076 0.0212 0.0253
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.0076 0.0212 0.0103
Echinococcus multilocularis roundabout 2 0.0039 0.0069 0.0082
Brugia malayi beta-tubulin, identical 0.0321 0.1168 0.1444
Echinococcus multilocularis tyrosine protein kinase HCK 0.0043 0.0082 0.0098
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0069 0.0185 0.0179
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0076 0.0212 0.0034
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0295 0.1063 0.1268
Brugia malayi TAR-binding protein 0.0069 0.0185 0.0229
Leishmania major carbonic anhydrase family protein, putative 0.1073 0.4094 0.4881
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0064 0.0164 0.0157
Echinococcus granulosus protein kinase shaggy 0.0257 0.0916 0.1093
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0076 0.0212 0.026
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0828 0.3141 0.3606
Echinococcus multilocularis epidermal growth factor receptor 0.0522 0.1949 0.2325
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0136 0.0446 0.0852
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0069 0.0185 0.0179
Schistosoma mansoni nephrin related 0.0022 0.0002 0.0002
Brugia malayi Carboxyl transferase domain containing protein 0.2098 0.8086 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.005 0.011 0.0132
Mycobacterium leprae Probable transmembrane transport protein 0.0501 0.1867 0.4552
Echinococcus multilocularis basement membrane specific heparan sulfate 0.003 0.0033 0.0039
Schistosoma mansoni tyrosine kinase 0.005 0.011 0.0132
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0076 0.0212 0.0047
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0723 0.2731 0.3258
Schistosoma mansoni nephrin 0.0039 0.0069 0.0082
Loa Loa (eye worm) hypothetical protein 0.0306 0.1107 0.1367
Echinococcus granulosus beta tubulin 0.0321 0.1168 0.1393
Echinococcus multilocularis Immunoglobulin 0.0022 0.0002 0.0002
Toxoplasma gondii beta-tubulin, putative 0.0321 0.1168 0.1365
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0063
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.1168 0.1393
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0083
Loa Loa (eye worm) blistered cuticle protein 3 0.0078 0.0218 0.0267
Trypanosoma brucei alpha tubulin 0.0259 0.0926 0.0904
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.2098 0.8086 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0069 0.0086
Onchocerca volvulus 0.0257 0.0916 0.2304
Leishmania major gamma-tubulin 0.0181 0.062 0.0734
Leishmania major alpha tubulin 0.0259 0.0926 0.1099
Echinococcus multilocularis cyclin dependent kinase 0.0096 0.0291 0.0347
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0126 0.0405 0.0484
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0295 0.1063 0.1262
Echinococcus granulosus basement membrane specific heparan sulfate 0.0022 0.0002 0.0002
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0029 0.0027 0.0034
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0097 0.0115
Loa Loa (eye worm) tubulin beta chain 0.0321 0.1168 0.1442
Echinococcus multilocularis expressed protein 0.0361 0.132 0.1575
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0039 0.0069 0.0083
Trichomonas vaginalis tubulin gamma chain, putative 0.0181 0.062 0.0613
Schistosoma mansoni tyrosine kinase 0.0508 0.1893 0.2258
Leishmania major alpha tubulin 0.0259 0.0926 0.1099
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.005 0.011 0.0132
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0064 0.0164 0.0157
Toxoplasma gondii pyruvate carboxylase 0.0828 0.3141 0.3726
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.0716 0.1375
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0096 0.0291 0.0358
Echinococcus granulosus cyclin dependent kinase 5 0.0096 0.0291 0.0347
Schistosoma mansoni hypothetical protein 0.0022 0.0002 0.0002
Schistosoma mansoni cell adhesion molecule 0.0022 0.0002 0.0002
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0187 0.0644 0.064
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0267
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0136 0.0446 0.0552
Schistosoma mansoni hypothetical protein 0.0029 0.0027 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.011 0.0131
Echinococcus granulosus Immunoglobulin subtype 0.0022 0.0002 0.0002
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0218 0.0267
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0096 0.0291 0.0358
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0371 0.1359 0.3312
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0136 0.0446 0.0532
Plasmodium falciparum tubulin beta chain 0.0321 0.1168 0.1896
Mycobacterium ulcerans hypothetical protein 0.0119 0.0377 0.0372
Echinococcus multilocularis RUN 0.0172 0.0586 0.0699
Brugia malayi hypothetical protein 0.0156 0.0523 0.0647
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0076 0.0212 0.0253
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0076 0.0212 0.0034
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0126 0.0405 0.0501
Schistosoma mansoni tyrosine kinase 0.0522 0.1949 0.2325
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0069 0.0185 0.0344
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0076 0.0212 0.0397
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0083
Echinococcus multilocularis protein patched 0.0056 0.0134 0.016
Brugia malayi Tubulin alpha chain 0.0079 0.0222 0.0274
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Mycobacterium ulcerans pyruvate carboxylase 0.0828 0.3141 0.3137
Loa Loa (eye worm) hypothetical protein 0.0076 0.0212 0.026
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.005 0.011 0.0132
Loa Loa (eye worm) tubulin alpha-3 chain 0.0157 0.0527 0.065
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0043 0.0084 0.0102
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0008 0.0003
Trypanosoma brucei acetyl-CoA carboxylase 0.2174 0.8383 1
Leishmania major acetyl-CoA carboxylase, putative 0.2174 0.8383 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0032
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0295 0.1063 0.2586
Schistosoma mansoni hypothetical protein 0.0022 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.0723 0.2731 0.3377
Leishmania major alpha tubulin 0.0259 0.0926 0.1099
Giardia lamblia Beta tubulin 0.0321 0.1168 0.8394
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.011 0.0131
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0027 0.0032
Trypanosoma brucei alpha tubulin 0.0259 0.0926 0.0904
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0095 0.0287 0.0343
Schistosoma mansoni cell adhesion molecule 0.0039 0.0069 0.0082
Trichomonas vaginalis tubulin beta chain, putative 0.0259 0.0926 0.0919
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0828 0.3141 0.3941
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0002 0.0001
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.1168 0.1393
Trichomonas vaginalis tubulin beta chain, putative 0.0259 0.0926 0.0919
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0284 0.0339
Echinococcus multilocularis tubulin alpha chain 0.0259 0.0926 0.1105
Treponema pallidum cell division protein FtsZ 0.0079 0.0222 0.0065
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0027 0.0034
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.005 0.011 0.0132
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0295 0.1063 0.1262
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0022 0.0002 0.0002
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0096 0.0291 0.0341
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0076 0.0212 0.0034
Brugia malayi hypothetical protein 0.0039 0.0068 0.0085
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0069 0.0086
Echinococcus multilocularis Immunoglobulin 0.003 0.0033 0.0039
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0185 0.0229
Schistosoma mansoni alpha tubulin 0.0259 0.0926 0.1105
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0076 0.0212 0.0247
Toxoplasma gondii carbamoylphosphate synthetase 0.0187 0.0644 0.0739
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0069 0.0086
Trypanosoma brucei beta tubulin 0.0321 0.1168 0.1199
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0295 0.1063 0.1058
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0069 0.0082
Echinococcus multilocularis hemicentin 1 0.0039 0.0069 0.0082
Echinococcus granulosus tubulin delta chain 0.0079 0.0222 0.0264
Schistosoma mansoni tyrosine kinase 0.0054 0.0125 0.015
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0257 0.0916 0.1093
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0187 0.0644 0.0769
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0069 0.0086
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0195 0.0233
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0187 0.0644 0.0785
Loa Loa (eye worm) alpha-tubulin 0.0259 0.0926 0.1143
Loa Loa (eye worm) tubulin alpha-2 chain 0.0259 0.0926 0.1143
Echinococcus granulosus tubulin beta 4A class IVa 0.0321 0.1168 0.1393
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0185 0.022
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0008 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0005 0.0007
Echinococcus granulosus carbonic anhydrase II 0.0126 0.0405 0.0484
Echinococcus multilocularis beta tubulin 0.0321 0.1168 0.1393
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0069 0.0086
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0284 0.0339
Trypanosoma cruzi cdc2-related kinase 1 0.0096 0.0291 0.055
Schistosoma mansoni tubulin subunit epsilon 0.0181 0.062 0.074
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0076 0.0212 0.0307
Schistosoma mansoni nephrin 0.0047 0.01 0.012
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0187 0.0644 0.1476
Trypanosoma brucei beta tubulin 0.0321 0.1168 0.1199
Trichomonas vaginalis tubulin beta chain, putative 0.0321 0.1168 0.1161
Trichomonas vaginalis tubulin, putative 0.0102 0.0314 0.0307
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0267
Echinococcus granulosus tubulin alpha 3 chain 0.0259 0.0926 0.1105
Trichomonas vaginalis tubulin beta chain, putative 0.0102 0.0314 0.0307
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.011 0.0131
Trypanosoma cruzi alpha tubulin, putative 0.0259 0.0926 0.1783
Brugia malayi basement membrane proteoglycan 0.0022 0.0002 0.0002
Entamoeba histolytica protein kinase, putative 0.0257 0.0916 0.2228
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0079 0.0222 0.0233
Loa Loa (eye worm) tubulin beta chain 0.0079 0.0222 0.0272
Echinococcus granulosus roundabout 2 0.0039 0.0069 0.0082
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0076 0.0212 0.0221
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0027 0.0034
Trypanosoma brucei epsilon tubulin 0.0181 0.062 0.0531
Loa Loa (eye worm) BEN-1 protein 0.0321 0.1168 0.1442
Schistosoma mansoni tubulin subunit beta 0.0321 0.1168 0.1393
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0395 0.0487
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Schistosoma mansoni basigin related 0.0022 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0083
Schistosoma mansoni hypothetical protein 0.0022 0.0002 0.0002
Echinococcus granulosus beta tubulin 0.0321 0.1168 0.1393
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0022 0.0002 0.0002
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0076 0.0212 0.0262
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.1168 0.1393
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0295 0.1063 0.1329
Echinococcus granulosus neuroglian 0.0047 0.01 0.012
Plasmodium falciparum alpha tubulin 2 0.0259 0.0926 0.1494
Loa Loa (eye worm) hypothetical protein 0.0052 0.0119 0.0145
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0002 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0069 0.0086
Leishmania major alpha tubulin 0.0259 0.0926 0.1099
Trichomonas vaginalis tubulin, putative 0.0102 0.0314 0.0307
Trypanosoma brucei unspecified product 0.0544 0.2036 0.2258
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1073 0.4094 0.5063
Echinococcus granulosus tyrosine protein kinase HCK 0.0043 0.0082 0.0098
Mycobacterium ulcerans cell division protein FtsZ 0.0079 0.0222 0.0216
Echinococcus multilocularis protein dispatched 1 0.0056 0.0134 0.016
Onchocerca volvulus 0.0102 0.0314 0.0782
Schistosoma mansoni lipoxygenase 0.0622 0.2338 0.2789
Plasmodium vivax tubulin alpha chain, putative 0.0259 0.0926 0.1266
Trypanosoma cruzi cdc2-related kinase 1 0.0096 0.0291 0.055
Plasmodium falciparum LCCL domain-containing protein 0.0172 0.0586 0.0929
Schistosoma mansoni tubulin subunit beta 0.0079 0.0222 0.0264
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0076 0.0212 0.0034
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0076 0.0212 0.0103
Trypanosoma brucei tubulin delta chain 0.0079 0.0222 0.0045
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0218 0.0267
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0828 0.3141 0.3747
Echinococcus multilocularis Immunoglobulin subtype 0.0022 0.0002 0.0002
Trichomonas vaginalis tubulin alpha chain, putative 0.0102 0.0314 0.0307
Trypanosoma brucei hypothetical protein, conserved 0.0206 0.0716 0.0648
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0022 0.0002 0.0002
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.1168 0.1393
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0076 0.0212 0.0253
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Mycobacterium ulcerans hypothetical protein 0.0024 0.0008 0.0002
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0218 0.0269
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0284 0.0339
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0257 0.0916 0.1131
Echinococcus multilocularis Immunoglobulin 0.0022 0.0002 0.0002
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0828 0.3141 0.3137
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0005
Echinococcus multilocularis hypothetical protein 0.0259 0.0926 0.1105
Brugia malayi cell division control protein 2 homolog 0.0096 0.0291 0.036
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0005 0.0007
Echinococcus granulosus carbonic anhydrase 0.0029 0.0027 0.0032
Trypanosoma brucei cdc2-related kinase 3 0.0096 0.0291 0.013
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.011 0.0132
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.005 0.011 0.0132
Toxoplasma gondii beta-1 tubulin, putative 0.0321 0.1168 0.1365
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0068 0.0082
Plasmodium falciparum glycogen synthase kinase 3 0.0257 0.0916 0.1478
Echinococcus multilocularis tubulin subunit TubB 0.0259 0.0926 0.1105
Echinococcus granulosus tyrosine protein kinase Lyn 0.0054 0.0125 0.0149
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0185 0.022
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Schistosoma mansoni cell adhesion molecule 0.0039 0.0069 0.0082
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0022 0.0002 0.0002
Trypanosoma brucei alpha tubulin 0.0259 0.0926 0.0904
Entamoeba histolytica tubulin alpha chain, putative 0.0259 0.0926 0.2252
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0257 0.0916 0.1087
Loa Loa (eye worm) tubulin beta-2A chain 0.0321 0.1168 0.1442
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0267
Echinococcus granulosus Protein patched homolog 1 0.0056 0.0134 0.016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.011 0.0131
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0076 0.0212 0.0103
Leishmania major delta tubulin, putative 0.0079 0.0222 0.0258
Onchocerca volvulus 0.0078 0.0218 0.0538
Leishmania major carbonic anhydrase-like protein 0.0126 0.0405 0.0478
Schistosoma mansoni septate junction protein 0.0039 0.0069 0.0082
Loa Loa (eye worm) TK protein kinase 0.0046 0.0097 0.0117
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0002 0.0002
Echinococcus granulosus Tubulin alpha 1 chain 0.0259 0.0926 0.1105
Echinococcus multilocularis cyclin dependent kinase 1 0.0096 0.0291 0.0347
Mycobacterium tuberculosis Conserved protein 0.0024 0.0008 0.0003
Trypanosoma cruzi tubulin gamma chain 0.0181 0.062 0.119
Echinococcus multilocularis tubulin alpha chain 0.0259 0.0926 0.1105
Echinococcus granulosus cyclin dependent kinase 0.0096 0.0291 0.0347
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0828 0.3141 0.6084
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0027 0.0032
Schistosoma mansoni tyrosine kinase 0.005 0.011 0.0132
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0022 0.0002 0.0002
Echinococcus multilocularis netrin receptor unc 5 0.0036 0.0056 0.0067
Echinococcus multilocularis hemicentin 1 0.0039 0.0069 0.0082
Brugia malayi alpha-tubulin 0.0259 0.0926 0.1145
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0079 0.0222 0.0032
Trypanosoma brucei beta tubulin 0.0321 0.1168 0.1199
Echinococcus multilocularis epidermal growth factor receptor 0.0746 0.282 0.3364
Echinococcus multilocularis lipoxygenase domain containing protein 0.0172 0.0586 0.0699
Schistosoma mansoni tyrosine kinase 0.0508 0.1893 0.2258
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0622 0.2338 0.2789
Trypanosoma brucei tubulin gamma chain 0.0181 0.062 0.0531
Brugia malayi Furin-like cysteine rich region family protein 0.0746 0.282 0.3487
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0029 0.0027 0.0034
Plasmodium vivax tubulin epsilon chain, putative 0.0181 0.062 0.0744
Echinococcus granulosus tyrosine protein kinase Src42A 0.005 0.011 0.0132
Trichomonas vaginalis tubulin beta chain, putative 0.0259 0.0926 0.0919
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0257 0.0916 0.1131
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.011 0.0131
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0291 0.0347
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0828 0.3141 0.3137
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0002 0.0001
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0096 0.0291 0.0316
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0284 0.0333
Brugia malayi Tubulin beta-1 chain 0.0321 0.1168 0.1444
Loa Loa (eye worm) TK protein kinase 0.0032 0.0039 0.0047
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0267
Schistosoma mansoni alpha tubulin 0.0259 0.0926 0.1105
Trichomonas vaginalis CMGC family protein kinase 0.0257 0.0916 0.0909
Loa Loa (eye worm) hypothetical protein 0.0093 0.0276 0.034
Brugia malayi CHE-14 protein 0.0056 0.0134 0.0166
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0157 0.0527 0.052
Echinococcus multilocularis protein kinase shaggy 0.0257 0.0916 0.1093
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0069 0.0082
Entamoeba histolytica tubulin family protein 0.0321 0.1168 0.2842
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.1168 0.1393
Brugia malayi Protein kinase domain containing protein 0.0096 0.0291 0.036
Trichomonas vaginalis conserved hypothetical protein 0.2589 1 1
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0076 0.0212 0.0506
Loa Loa (eye worm) tubulin beta-4 chain 0.0321 0.1168 0.1442
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0039 0.0049
Trichomonas vaginalis tubulin alpha chain, putative 0.0321 0.1168 0.1161
Treponema pallidum ATP-binding protein (ylxH-1) 0.0446 0.1653 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0033 0.0039
Schistosoma mansoni tyrosine kinase 0.0522 0.1949 0.2325
Schistosoma mansoni peroxidasin 0.01 0.0304 0.0363
Echinococcus multilocularis tyrosine protein kinase Src64B 0.005 0.011 0.0132
Onchocerca volvulus 0.0078 0.0218 0.0538
Echinococcus granulosus Immunoglobulin 0.0022 0.0002 0.0002
Loa Loa (eye worm) BEN-1 protein 0.0321 0.1168 0.1442
Trichomonas vaginalis tubulin, putative 0.0321 0.1168 0.1161
Plasmodium falciparum tubulin gamma chain 0.0181 0.062 0.0986
Echinococcus granulosus contactin 0.0039 0.0069 0.0082
Echinococcus multilocularis Biotin lipoyl attachment 0.0076 0.0212 0.0253
Brugia malayi Tubulin alpha-2 chain 0.0259 0.0926 0.1145
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0185 0.0227
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0076 0.0212 0.0253
Entamoeba histolytica tubulin gamma chain 0.0181 0.062 0.1504
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0187 0.0644 0.1236
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0096 0.0291 0.0347
Plasmodium falciparum carbamoyl phosphate synthetase 0.0187 0.0644 0.1026
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0102 0.0314 0.0307
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0267
Schistosoma mansoni loxhd1 0.0172 0.0586 0.0699
Plasmodium falciparum tubulin delta chain, putative 0.0079 0.0222 0.0323
Brugia malayi tubulin alpha chain - mouse 0.0259 0.0926 0.1145
Trypanosoma cruzi cdc2-related kinase 3 0.0096 0.0291 0.055
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0295 0.1063 0.1071
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0371 0.1359 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0181 0.062 0.0613
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0828 0.3141 0.3747
Schistosoma mansoni tyrosine kinase 0.0723 0.2731 0.3258
Echinococcus multilocularis tubulin alpha chain 0.0259 0.0926 0.1105
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0284 0.035
Trypanosoma brucei alpha tubulin 0.0259 0.0926 0.0904
Trichomonas vaginalis tubulin beta chain, putative 0.0259 0.0926 0.0919
Onchocerca volvulus 0.0172 0.0586 0.1469
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0267
Echinococcus granulosus peroxisome assembly protein 26 0.0259 0.0926 0.1105
Entamoeba histolytica tubulin family protein 0.0321 0.1168 0.2842
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Brugia malayi Tubulin beta chain 0.0102 0.0314 0.0389
Toxoplasma gondii beta tubulin 0.0321 0.1168 0.1365
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0096 0.0291 0.0358
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0032 0.0039 0.0047
Schistosoma mansoni tubulin subunit beta 0.0321 0.1168 0.1393
Leishmania major zeta tubulin, putative 0.0079 0.0222 0.0258
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0008 0.0003
Schistosoma mansoni tubulin subunit beta 0.0321 0.1168 0.1393
Loa Loa (eye worm) carbonic anhydrase 3 0.0126 0.0405 0.0499
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0195 0.0233
Brugia malayi RNA binding protein 0.0069 0.0185 0.0229
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0259 0.0926 0.0919
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0295 0.1063 0.1058
Schistosoma mansoni hypothetical protein 0.0022 0.0002 0.0002
Echinococcus multilocularis neuroglian 0.0047 0.01 0.012
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0126 0.0405 0.0499
Echinococcus granulosus tubulin alpha chain 0.0259 0.0926 0.1105
Schistosoma mansoni netrin receptor unc5 0.0022 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.0716 0.1375
Echinococcus granulosus carbonic anhydrase 0.0029 0.0027 0.0032
Trichomonas vaginalis tubulin epsilon chain, putative 0.0259 0.0926 0.0919
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0069 0.0086
Schistosoma mansoni basigin related 0.0022 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0051 0.0116 0.0141
Echinococcus multilocularis Tubulin alpha 1 chain 0.0259 0.0926 0.1105
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0076 0.0212 0.0221
Echinococcus granulosus hemicentin 1 0.0039 0.0069 0.0082
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0126 0.0405 0.0501
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0053 0.0065
Mycobacterium ulcerans integral membrane transporter 0.0069 0.0185 0.0179
Trichomonas vaginalis tubulin gamma chain, putative 0.0181 0.062 0.0613
Schistosoma mansoni rab6-interacting 0.0172 0.0586 0.0699
Echinococcus multilocularis cyclin dependent kinase 5 0.0096 0.0291 0.0347
Echinococcus multilocularis cyclin dependent kinase 1 0.0096 0.0291 0.0347
Brugia malayi Heparan sulfate 0.0022 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0267
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0069 0.0185 0.0344
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0002 0.0003
Schistosoma mansoni tubulin subunit alpha 0.0259 0.0926 0.1105
Trypanosoma cruzi epsilon tubulin, putative 0.0181 0.062 0.119
Brugia malayi Immunoglobulin I-set domain containing protein 0.1073 0.4094 0.5064
Leishmania major beta tubulin 0.0321 0.1168 0.1387
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0076 0.0212 0.0253
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0022 0.0002 0.0002
Schistosoma mansoni aspartate carbamoyltransferase 0.0187 0.0644 0.0769
Brugia malayi hypothetical protein 0.003 0.0033 0.0041
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.1168 0.1393
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0395 0.0487
Echinococcus multilocularis peroxidasin 0.0117 0.0371 0.0443
Schistosoma mansoni tubulin subunit beta 0.0321 0.1168 0.1393
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0039 0.0069 0.0083
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0187 0.0644 0.0561
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.011 0.0132
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0295 0.1063 0.2586
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0076 0.0212 0.0221
Plasmodium falciparum alpha tubulin 1 0.0259 0.0926 0.1494
Leishmania major carboxylase, putative 0.0828 0.3141 0.3743
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0076 0.0212 0.0397
Leishmania major alpha tubulin 0.0259 0.0926 0.1099
Loa Loa (eye worm) hypothetical protein 0.0172 0.0586 0.0723
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0522 0.1949 0.2325
Schistosoma mansoni tubulin subunit alpha 0.0259 0.0926 0.1105
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0022 0.0002 0.0002
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0295 0.1063 0.2049
Schistosoma mansoni rab6-interacting 0.0172 0.0586 0.0699
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.005 0.011 0.0132
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0295 0.1063 0.3302
Echinococcus granulosus lipoxygenase domain containing protein 0.0172 0.0586 0.0699
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0116 0.0141
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0039 0.0069 0.0082
Loa Loa (eye worm) tubulin alpha 2 0.0078 0.0221 0.0272
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.1024 0.3905 0.4902
Schistosoma mansoni cell adhesion molecule 0.0022 0.0002 0.0002
Echinococcus multilocularis roundabout 2 0.0039 0.0069 0.0082
Schistosoma mansoni hypothetical protein 0.0172 0.0586 0.0699
Leishmania major alpha tubulin 0.0259 0.0926 0.1099
Trichomonas vaginalis tubulin alpha chain, putative 0.0102 0.0314 0.0307
Trichomonas vaginalis tubulin epsilon chain, putative 0.0321 0.1168 0.1161
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0039 0.0069 0.0083
Echinococcus multilocularis tubulin alpha 0.0181 0.062 0.074
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0321 0.1168 0.1393
Loa Loa (eye worm) hypothetical protein 0.003 0.0033 0.0039
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0126 0.0405 0.0484
Echinococcus granulosus Niemann Pick C1 protein 0.0056 0.0134 0.016
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0218 0.0269
Echinococcus multilocularis beta tubulin 0.0321 0.1168 0.1393
Giardia lamblia Kinase, CMGC GSK 0.0257 0.0916 0.6291
Trypanosoma brucei beta tubulin 0.0321 0.1168 0.1199
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0076 0.0212 0.0247
Brugia malayi tubulin alpha-2 chain 0.0259 0.0926 0.1145
Schistosoma mansoni acetyl-CoA carboxylase 0.2174 0.8383 1
Echinococcus granulosus Immunoglobulin 0.0022 0.0002 0.0002
Leishmania major alpha tubulin 0.0259 0.0926 0.1099
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0002 0.0002
Trypanosoma brucei protein kinase, putative 0.0257 0.0916 0.0892
Loa Loa (eye worm) hypothetical protein 0.0156 0.0523 0.0645
Trypanosoma cruzi acetyl-CoA carboxylase 0.1346 0.5157 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0079 0.0222 0.0272
Giardia lamblia Epsilon tubulin 0.0079 0.0222 0.0477
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0027 0.0032

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 1459 umol/L Cytotoxicity against human WISH cells ChEMBL. 25515560

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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