Detailed information for compound 1030217

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 270.782 | Formula: C11H15ClN4S
  • H donors: 1 H acceptors: 2 LogP: 3.13 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1nnc(s1)CCc1ccccc1)N.Cl
  • InChi: 1S/C11H14N4S.ClH/c1-15(12)11-14-13-10(16-11)8-7-9-5-3-2-4-6-9;/h2-6H,7-8,12H2,1H3;1H
  • InChiKey: BOZHOMSFVFQQPV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0095 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0036 0.0174 0.0213
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0027 0.0076 0.0333
Echinococcus multilocularis para nitrobenzyl esterase 0.0095 0.0856 0.0856
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0739 0.8173 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0157 0.1559 0.84
Trichomonas vaginalis spcc417.12 protein, putative 0.0095 0.0856 0.3032
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0192 0.1022
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0531 0.0531
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.049 0.049
Onchocerca volvulus 0.017 0.1703 0.2399
Echinococcus multilocularis carboxylesterase 5A 0.0565 0.6198 0.6198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0299 0.3167 0.3874
Onchocerca volvulus 0.0095 0.0856 0.1133
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0299 0.3167 0.3167
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0029 0.0098 0.523
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0539 0.5904 0.5904
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0668 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0215 0.0215
Brugia malayi nuclear hormone receptor family member nhr-6 0.0137 0.1327 0.1623
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0215 0.0762
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0004 0.0013
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0157 0.1559 0.84
Entamoeba histolytica hypothetical protein 0.0115 0.108 0.5286
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0029 0.0098 0.0546
Brugia malayi exodeoxyribonuclease III family protein 0.0079 0.0668 0.0817
Echinococcus multilocularis dnaJ subfamily B 0.0891 0.9911 0.9911
Loa Loa (eye worm) RNA binding protein 0.0067 0.0531 0.065
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0065 0.0514 0.0514
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0145 0.1415 0.1415
Brugia malayi steroid hormone receptor 0.0299 0.3167 0.3874
Schistosoma mansoni polycystin 1-related 0.0043 0.0258 0.0258
Brugia malayi Niemann-Pick C1 protein precursor 0.02 0.2043 0.25
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0029 0.0098 0.012
Plasmodium vivax geranylgeranyltransferase, putative 0.0021 0.0011 0.0118
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0021 0.0011 0.0118
Brugia malayi polk-prov protein 0.0033 0.0143 0.0175
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0145 0.1415 0.7613
Loa Loa (eye worm) hypothetical protein 0.0162 0.161 0.1969
Leishmania major mitochondrial DNA topoisomerase II 0.0051 0.0355 0.1903
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0299 0.3167 0.3874
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0021 0.0011 0.0011
Giardia lamblia Leucyl-tRNA synthetase 0.0022 0.0025 0.0184
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0059 0.0439 0.2358
Loa Loa (eye worm) abnormal epIthelia family member 0.0052 0.0358 0.0438
Toxoplasma gondii hypothetical protein 0.0029 0.0098 0.0546
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0145 0.1415 0.7629
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0021 0.0011 0.0013
Echinococcus granulosus Nuclear hormone receptor HR96 0.0137 0.1327 0.1327
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0299 0.3167 0.3167
Brugia malayi Cytochrome P450 family protein 0.0027 0.0076 0.0093
Echinococcus multilocularis Niemann Pick C1 protein 0.0345 0.3696 0.3696
Brugia malayi MH2 domain containing protein 0.0117 0.1102 0.1349
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0027 0.0076 0.0333
Schistosoma mansoni hypothetical protein 0.0115 0.108 0.108
Loa Loa (eye worm) hypothetical protein 0.0299 0.3167 0.3874
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0183 0.1854 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0157 0.1559 0.84
Entamoeba histolytica Ran family GTPase 0.0021 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.012
Echinococcus granulosus importin subunit beta 1 0.0028 0.0087 0.0087
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.1922 0.1922
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0215 0.1147
Loa Loa (eye worm) hypothetical protein 0.0033 0.0143 0.0175
Schistosoma mansoni cytochrome P450 0.0027 0.0076 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0263 0.1407
Loa Loa (eye worm) hypothetical protein 0.0299 0.3167 0.3874
Loa Loa (eye worm) hypothetical protein 0.0137 0.1327 0.1623
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0299 0.3167 0.3874
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0263 0.0263
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0021 0.0011 0.0118
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0021 0.0011 0.0011
Echinococcus granulosus snurportin 1 0.0297 0.3154 0.3154
Trichomonas vaginalis conserved hypothetical protein 0.0145 0.1423 0.504
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0145 0.1423 0.174
Brugia malayi RNA binding protein 0.0067 0.0531 0.065
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0192 0.0235
Giardia lamblia Rab geranylgeranyltransferase 0.0021 0.0011 0.0066
Loa Loa (eye worm) hypothetical protein 0.0149 0.146 0.1786
Plasmodium vivax DNA gyrase subunit B, putative 0.0022 0.0015 0.0176
Brugia malayi nuclear hormone receptor 0.0137 0.1327 0.1623
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0498 0.0498
Echinococcus multilocularis 0.0027 0.0076 0.0076
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0263 0.0933
Plasmodium vivax multidomain scavenger receptor, putative 0.0043 0.0258 0.3841
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0003 0.0003
Brugia malayi hypothetical protein 0.0115 0.108 0.1321
Plasmodium falciparum geranylgeranyltransferase, putative 0.0021 0.0011 0.0118
Brugia malayi laminin-like protein K08C7.3 precursor 0.0052 0.0358 0.0438
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0299 0.3167 0.3167
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0668 1
Schistosoma mansoni gliotactin 0.0095 0.0856 0.0856
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.02 0.2043 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0137 0.1327 0.1623
Echinococcus granulosus sodium and chloride dependent glycine 0.0029 0.0098 0.0098
Echinococcus multilocularis sterol regulatory element binding protein 0.0145 0.1423 0.1423
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0299 0.3167 0.3167
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0157 0.1559 0.84
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0051 0.0355 0.1903
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0004 0.0013
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0029 0.0098 0.012
Echinococcus multilocularis protein patched 0.0145 0.1423 0.1423
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0157 0.1559 0.84
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0263 0.1407
Brugia malayi nuclear receptor NHR-88 0.0137 0.1327 0.1623
Loa Loa (eye worm) hypothetical protein 0.0095 0.0856 0.1047
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0021 0.0011 0.0045
Echinococcus multilocularis GPCR, family 2 0.0064 0.0498 0.0498
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0263 0.1407
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0027 0.0094
Leishmania major cytochrome p450-like protein 0.0027 0.0076 0.0394
Echinococcus granulosus ubiquitin specific protease 41 0.0126 0.1199 0.1199
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0668 0.2367
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0005 0.0007
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0147 0.144 0.144
Trypanosoma brucei lanosterol synthase 0.0155 0.1531 0.8259
Schistosoma mansoni ran 0.0021 0.0003 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0005 0.0005
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0099 0.0121
Echinococcus granulosus para nitrobenzyl esterase 0.0095 0.0856 0.0856
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0563 0.2757
Loa Loa (eye worm) hypothetical protein 0.0043 0.0258 0.0316
Loa Loa (eye worm) hypothetical protein 0.061 0.6715 0.8215
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0357 0.0357
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0215 0.1147
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0357 0.1264
Plasmodium vivax methionine--tRNA ligase, putative 0.0022 0.0025 0.0331
Loa Loa (eye worm) hypothetical protein 0.0095 0.0856 0.1047
Schistosoma mansoni thyroid hormone receptor 0.0445 0.4837 0.4837
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0183 0.1854 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0357 0.1264
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0498 0.061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0299 0.3167 0.3874
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0531 0.0531
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0029 0.0098 0.0098
Echinococcus multilocularis neuroligin 0.0095 0.0856 0.0856
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0357 0.1264
Brugia malayi Nuclear hormone receptor-like 1 0.0162 0.161 0.1969
Loa Loa (eye worm) hypothetical protein 0.0202 0.2073 0.2536
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0263 0.1407
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0021 0.0011 0.0038
Schistosoma mansoni nuclear receptor 0.0137 0.1327 0.1327
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0011 0.0042
Echinococcus multilocularis lamin dm0 0.0085 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0158 0.1572 0.1923
Echinococcus granulosus sterol regulatory element binding protein 0.0145 0.1423 0.1423
Echinococcus granulosus carboxylesterase 5A 0.0565 0.6198 0.6198
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.108 0.108
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0059 0.0438 0.1553
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0011 0.0045
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.012
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0157 0.1559 0.84
Schistosoma mansoni sodium/chloride dependent transporter 0.017 0.1703 0.1703
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0147 0.144 0.144
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0137 0.1327 0.1327
Echinococcus multilocularis RUN 0.0043 0.0258 0.0258
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0021 0.0011 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0013
Echinococcus granulosus slit 2 protein 0.0052 0.0358 0.0358
Loa Loa (eye worm) nuclear receptor NHR-67 0.0137 0.1327 0.1623
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0059 0.0438 0.2304
Loa Loa (eye worm) hypothetical protein 0.0158 0.1572 0.1923
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0027 0.0076 0.0333
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0029 0.0098 0.0098
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0005 0.0005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.004 0.004
Toxoplasma gondii DNA topoisomerase 2, putative 0.0065 0.0514 0.2941
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0803 0.0982
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0168 0.0625
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0299 0.3167 0.3167
Brugia malayi ecdysteroid receptor 0.0617 0.6788 0.8306
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0299 0.3167 0.3167
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0029 0.0098 0.0098
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0299 0.3167 0.3874
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0299 0.3167 0.3167
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.012
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0563 0.0689
Schistosoma mansoni importin beta-1 0.0028 0.0087 0.0087
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0357 0.1912
Entamoeba histolytica hypothetical protein 0.0115 0.108 0.5286
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.1253 0.6735
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0095 0.0856 0.0856
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0299 0.3167 0.3167
Brugia malayi Nuclear hormone receptor-like 1 0.0162 0.161 0.1969
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0145 0.1415 0.7629
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0027 0.0076 0.0333
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0079 0.0668 0.0668
Echinococcus multilocularis lamin 0.0085 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0095 0.0856 0.1047
Brugia malayi intermediate filament protein 0.0085 0.0738 0.0903
Echinococcus granulosus lamin dm0 0.0085 0.0738 0.0738
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.2455 0.3003
Schistosoma mansoni retinoic acid receptor RXR 0.0299 0.3167 0.3167
Onchocerca volvulus 0.0299 0.3167 0.4587
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0215 0.1147
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0299 0.3167 0.3874
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0079 0.0668 0.3554
Echinococcus multilocularis serotonin transporter 0.017 0.1703 0.1703
Mycobacterium ulcerans carboxylesterase, LipT 0.0095 0.0856 0.4574
Brugia malayi hypothetical protein 0.0043 0.0258 0.0316
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0262 0.2756 0.2756
Schistosoma mansoni cell polarity protein 0.0052 0.0358 0.0358
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0357 0.0357
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.108 0.108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1922 0.1922
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0299 0.3167 0.3167
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0029 0.0098 0.0098
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0052 0.0358 0.0358
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0299 0.3167 0.3167
Loa Loa (eye worm) hypothetical protein 0.0162 0.161 0.1969
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0299 0.3167 0.3874
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0027 0.0076 0.0333
Echinococcus granulosus thyroid hormone receptor alpha 0.0137 0.1327 0.1327
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0357 0.2036
Plasmodium falciparum DNA topoisomerase 2 0.0065 0.0514 0.7685
Mycobacterium ulcerans oxidoreductase 0.013 0.1253 0.6735
Brugia malayi RNA, U transporter 1 0.0079 0.0671 0.0821
Brugia malayi Pre-SET motif family protein 0.0236 0.2455 0.3003
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0183 0.1854 1
Schistosoma mansoni hypothetical protein 0.0064 0.0498 0.0498
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0126 0.1199 0.1199
Brugia malayi EGF-like domain containing protein 0.0052 0.0358 0.0438
Schistosoma mansoni lamin 0.0085 0.0738 0.0738
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0059 0.0438 0.2353
Onchocerca volvulus 0.0043 0.0258 0.024
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0174 0.0174
Toxoplasma gondii histone lysine methyltransferase SET1 0.0173 0.1741 1
Schistosoma mansoni rab6-interacting 0.0043 0.0258 0.0258
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0103 0.0126
Brugia malayi Carboxylesterase family protein 0.0095 0.0856 0.1047
Leishmania major leucyl-tRNA synthetase, putative 0.0022 0.0025 0.0119
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0263 0.1407
Loa Loa (eye worm) hypothetical protein 0.0052 0.0358 0.0438
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.012
Schistosoma mansoni loxhd1 0.0043 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0095 0.0856 0.1047
Echinococcus granulosus cpg binding protein 0.0096 0.0862 0.0862
Schistosoma mansoni BC026374 protein (S09 family) 0.0095 0.0856 0.0856
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0157 0.1559 0.84
Brugia malayi MAP kinase sur-1 0.0052 0.0357 0.0437
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0059 0.0438 0.2304
Schistosoma mansoni hypothetical protein 0.0138 0.1344 0.1344
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0263 0.1407
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0137 0.1327 0.1327
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0563 0.3028
Schistosoma mansoni hypothetical protein 0.0064 0.0498 0.0498
Brugia malayi laminin alpha chain 0.0052 0.0358 0.0438
Plasmodium vivax methionine--tRNA ligase, putative 0.0059 0.0438 0.6546
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0174 0.0174
Plasmodium falciparum methionine--tRNA ligase 0.0059 0.0438 0.6546
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0011 0.0042
Echinococcus multilocularis muscleblind protein 1 0.0158 0.1572 0.1572
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0095 0.0856 0.1047
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0013
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0021 0.0011 0.0038
Echinococcus granulosus pikachurin 0.0052 0.0358 0.0358
Brugia malayi nuclear hormone receptor 0.0299 0.3167 0.3874
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0126 0.1199 0.1199
Schistosoma mansoni hypothetical protein 0.0147 0.144 0.144
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0027 0.0076 0.0333
Loa Loa (eye worm) hypothetical protein 0.0064 0.0498 0.061
Schistosoma mansoni inositol monophosphatase 0.0039 0.0215 0.0215
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0563 0.0689
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0738 0.0903
Onchocerca volvulus 0.0036 0.0174 0.0114
Schistosoma mansoni sodium/chloride dependent transporter 0.0029 0.0103 0.0103
Onchocerca volvulus 0.0137 0.1327 0.1837
Loa Loa (eye worm) hypothetical protein 0.0299 0.3167 0.3874
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0023 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0013
Onchocerca volvulus 0.0095 0.0856 0.1133
Echinococcus granulosus expressed protein 0.0394 0.4258 0.4258
Onchocerca volvulus 0.0043 0.0258 0.024
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0021 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0137 0.1327 0.1623
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0059 0.0438 0.6484
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.004 0.004
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0137 0.1327 0.1623
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0258 0.3841
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0157 0.1559 0.84
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0068 0.0541 0.1918
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0145 0.1415 0.7629
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0531 0.0531
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0137 0.1327 0.1837
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0299 0.3167 0.3874
Leishmania major DNA polymerase kappa, putative 0.0022 0.0023 0.0108
Schistosoma mansoni ap endonuclease 0.0079 0.0668 0.0668
Schistosoma mansoni neuroligin 3 (S09 family) 0.0095 0.0856 0.0856
Trypanosoma brucei protein kinase, putative 0.0052 0.0357 0.1912
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0563 0.3028
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0021 0.0011 0.0011
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0086 0.0745 0.3971
Loa Loa (eye worm) hypothetical protein 0.0162 0.161 0.1969
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0299 0.3167 0.3874
Echinococcus granulosus tar DNA binding protein 0.0067 0.0531 0.0531
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0563 0.0563
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0498 0.0498
Brugia malayi Steroid receptor seven-up type 2 0.0299 0.3167 0.3874
Plasmodium falciparum methionine--tRNA ligase, putative 0.0022 0.0025 0.0331
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0027 0.0076 0.0333
Brugia malayi Doublecortin family protein 0.0043 0.0258 0.0316
Loa Loa (eye worm) TOPoisomerase family member 0.0065 0.0514 0.0629
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0357 0.1912
Leishmania major geranylgeranyltransferase, putative 0.0021 0.0011 0.0042
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0215 0.1147
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0137 0.1327 0.1837
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0357 0.0357
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0004 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0004 0.0013
Schistosoma mansoni leucyl-tRNA synthetase 0.0022 0.0025 0.0025
Plasmodium falciparum amino acid transporter, putative 0.0029 0.0098 0.1427
Schistosoma mansoni patched 1 0.0145 0.1423 0.1423
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0027 0.0076 0.0333
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1199 0.4246
Trichomonas vaginalis set domain proteins, putative 0.0268 0.2823 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0103 0.0103
Brugia malayi hypothetical protein 0.0137 0.1327 0.1623
Loa Loa (eye worm) cytochrome P450 0.0027 0.0076 0.0093
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0021 0.0011 0.0011
Brugia malayi nuclear receptor NHR-67 0.0137 0.1327 0.1623
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0029 0.0098 0.012
Brugia malayi Carboxylesterase family protein 0.0095 0.0856 0.1047
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0023 0.0108
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0157 0.1559 0.84
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.1922 0.1922
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0021 0.0011 0.0011
Trichomonas vaginalis helicase, putative 0.0021 0.0004 0.0013
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0059 0.0438 0.2444
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.2073 0.2536
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0357 0.296
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0739 0.8173 0.8173
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0263 0.1407
Loa Loa (eye worm) hypothetical protein 0.017 0.1703 0.2084
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0051 0.0355 0.1903
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.2641 0.3232
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0137 0.1327 0.1623
Brugia malayi hypothetical protein 0.0149 0.146 0.1786
Echinococcus granulosus methionine tRNA synthetase 0.0059 0.0438 0.0438
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1102 0.1349
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0095 0.0856 0.0856
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0299 0.3167 0.3167
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0357 0.1912
Echinococcus multilocularis snurportin 1 0.0297 0.3154 0.3154
Echinococcus granulosus Nuclear hormone receptor HR96 0.0137 0.1327 0.1327
Brugia malayi hypothetical protein 0.0162 0.161 0.1969
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0739 0.8173 0.8173
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0079 0.0668 0.0817
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0229 0.0229
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0079 0.0668 0.327
Brugia malayi Pre-SET motif family protein 0.0036 0.0174 0.0213
Loa Loa (eye worm) carboxylesterase 0.0565 0.6198 0.7584
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0098 0.1427
Brugia malayi CXXC zinc finger family protein 0.0091 0.0803 0.0982
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0029 0.0098 0.0098
Schistosoma mansoni acetylcholinesterase 0.0095 0.0856 0.0856
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0003 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0263 0.1407
Echinococcus multilocularis thyroid hormone receptor alpha 0.0445 0.4837 0.4837
Loa Loa (eye worm) hypothetical protein 0.0052 0.0358 0.0438
Echinococcus multilocularis microtubule associated protein 2 0.0805 0.8925 0.8925
Entamoeba histolytica hypothetical protein 0.0115 0.108 0.5286
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.3154 0.3858
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0357 0.0357
Mycobacterium tuberculosis Carboxylesterase LipT 0.0095 0.0856 0.4574
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0027 0.0076 0.0394
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0021 0.0011 0.0038
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0027 0.0094
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0215 0.0215
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0095 0.0856 0.4574
Brugia malayi methionyl-tRNA synthetase 0.0059 0.0438 0.0536
Loa Loa (eye worm) hypothetical protein 0.0137 0.1327 0.1623
Plasmodium vivax amine transporter, putative 0.0029 0.0098 0.1427
Echinococcus multilocularis Polycystic kidney disease protein 0.0043 0.0258 0.0258
Giardia lamblia Methionyl-tRNA synthetase 0.0059 0.0438 0.3642
Schistosoma mansoni hypothetical protein 0.0083 0.071 0.071
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0498 0.061
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0157 0.1559 0.84
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0029 0.0098 0.0098
Giardia lamblia DINP protein human, muc B family 0.0022 0.0023 0.0168
Loa Loa (eye worm) hypothetical protein 0.0095 0.0856 0.1047
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0563 0.0563
Entamoeba histolytica hypothetical protein 0.0023 0.0027 0.013
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0011 0.0038
Echinococcus multilocularis cpg binding protein 0.0096 0.0862 0.0862
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0168 0.0837
Loa Loa (eye worm) inositol-1 0.0039 0.0215 0.0263
Brugia malayi Muscleblind-like protein 0.0158 0.1572 0.1923
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0079 0.0668 0.0668
Trypanosoma cruzi protein farnesyltransferase, putative 0.0021 0.0011 0.0042
Loa Loa (eye worm) carboxylesterase 0.0095 0.0856 0.1047
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.049 0.049
Schistosoma mansoni hypothetical protein 0.0891 0.9911 0.9911
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0022 0.0015 0.0067
Schistosoma mansoni hypothetical protein 0.0113 0.1053 0.1053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0299 0.3167 0.3874
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0103 0.0103
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0668 0.2367
Brugia malayi nuclear hormone receptor family member odr-7 0.0137 0.1327 0.1623
Loa Loa (eye worm) hypothetical protein 0.0299 0.3167 0.3874
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0183 0.1854 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0027 0.0076 0.0419
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0029 0.0098 0.0098
Echinococcus granulosus lamin 0.0085 0.0738 0.0738
Schistosoma mansoni hypothetical protein 0.0899 1 1
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0068 0.0541 0.4504
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0162 0.161 0.161
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0299 0.3167 0.3167
Treponema pallidum methionyl-tRNA synthetase 0.0022 0.0025 0.0061
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0029 0.0098 0.0098
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0299 0.3167 0.4587
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0059 0.0438 0.0536
Schistosoma mansoni microtubule-associated protein tau 0.0805 0.8925 0.8925
Loa Loa (eye worm) hypothetical protein 0.0162 0.161 0.1969
Echinococcus multilocularis leucyl tRNA synthetase 0.0022 0.0025 0.0025
Echinococcus granulosus BC026374 protein S09 family 0.0095 0.0856 0.0856
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.2073 0.2536
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0126 0.1199 0.1199
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0084 0.072 0.0881
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0005 0.0007
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0531 0.065
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0027 0.0094
Brugia malayi nuclear receptor NHR-88 0.0299 0.3167 0.3874
Brugia malayi Importin beta-1 subunit 0.0028 0.0087 0.0106
Schistosoma mansoni hypothetical protein 0.0083 0.071 0.071
Loa Loa (eye worm) solute carrier family 6 member 4 0.017 0.1703 0.2084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0004 0.0013
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0738 0.0903
Onchocerca volvulus 0.0149 0.146 0.2036
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0029 0.0098 0.012
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0263 0.1407
Echinococcus multilocularis slit 2 protein 0.0052 0.0358 0.0358
Echinococcus granulosus dnaJ subfamily B 0.0891 0.9911 0.9911
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0563 0.0563
Schistosoma mansoni methionine-tRNA synthetase 0.0022 0.0025 0.0025
Brugia malayi ecdysone receptor 0.0137 0.1327 0.1623
Loa Loa (eye worm) hypothetical protein 0.0299 0.3167 0.3874
Echinococcus granulosus Niemann Pick C1 protein 0.02 0.2043 0.2043
Brugia malayi photoreceptor-specific nuclear receptor 0.0299 0.3167 0.3874
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0021 0.0011 0.0118
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.1344 0.1645
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0068 0.0541 0.1918
Giardia lamblia DNA topoisomerase II 0.0063 0.0481 0.4001
Loa Loa (eye worm) steroid hormone receptor 0.0299 0.3167 0.3874
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0021 0.0011 0.0013
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0087 0.0087
Echinococcus granulosus intermediate filament protein 0.0085 0.0738 0.0738
Plasmodium vivax SET domain protein, putative 0.0036 0.0174 0.2573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0299 0.3167 0.3874
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0137 0.1327 0.1327
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0021 0.0011 0.0011
Schistosoma mansoni memapsin-2 (A01 family) 0.0469 0.5105 0.5105
Loa Loa (eye worm) hypothetical protein 0.0085 0.0738 0.0903
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0126 0.1199 0.1199
Schistosoma mansoni ran 0.0021 0.0003 0.0003
Onchocerca volvulus 0.0085 0.0738 0.0957
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0157 0.1559 0.84
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0126 0.1199 0.5866
Echinococcus granulosus acetylcholinesterase 0.0565 0.6198 0.6198
Loa Loa (eye worm) nuclear hormone receptor 0.0137 0.1327 0.1623
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0027 0.0076 0.0333
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0059 0.0439 0.2358
Toxoplasma gondii exonuclease III APE 0.0079 0.0668 0.3828
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0025 0.0331
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0183 0.1854 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0299 0.3167 0.3167
Loa Loa (eye worm) carboxylesterase 0.0095 0.0856 0.1047
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0126 0.1199 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0357 0.1912
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1922 0.1922
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.1922 0.2351
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0263 0.1407
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0068 0.0541 0.1918
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0079 0.0668 0.5564
Schistosoma mansoni cpg binding protein 0.0091 0.0803 0.0803
Echinococcus granulosus transcription factor Dp 1 0.004 0.0229 0.0229
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0299 0.3167 0.3874
Schistosoma mansoni lipoxygenase 0.012 0.1138 0.1138
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0021 0.0011 0.0013
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.049 0.2588
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0022 0.0025 0.0025
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0021 0.0011 0.0052
Loa Loa (eye worm) hypothetical protein 0.017 0.1703 0.2084
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0126 0.1199 0.1466
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0299 0.3167 0.3874
Giardia lamblia Prenyltransferase 0.0021 0.0011 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0299 0.3167 0.3874
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0029 0.0098 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0052 0.0358 0.0438
Schistosoma mansoni hypothetical protein 0.0043 0.0258 0.0258
Brugia malayi Nuclear hormone receptor E75 0.0137 0.1327 0.1623
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0157 0.1559 0.84
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0157 0.1559 0.84
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0357 0.0437
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0087 0.0452
Onchocerca volvulus Bile acid receptor homolog 0.0617 0.6788 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0738 0.0903
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0021 0.0011 0.0011
Treponema pallidum leucyl-tRNA synthetase 0.0022 0.0025 0.0061
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0022 0.0025 0.0025
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0157 0.1559 0.84
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0215 0.1053
Echinococcus multilocularis geminin 0.0899 1 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0029 0.0098 0.0098
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0263 0.0933
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0079 0.0668 0.3595
Echinococcus multilocularis pikachurin 0.0052 0.0358 0.0358
Plasmodium falciparum transporter, putative 0.0029 0.0098 0.1427
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.012
Echinococcus granulosus expressed conserved protein 0.0188 0.1905 0.1905
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0137 0.0137
Schistosoma mansoni ap endonuclease 0.0079 0.0668 0.0668
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0137 0.1327 0.1327
Brugia malayi TAR-binding protein 0.0067 0.0531 0.065
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0357 0.1912
Onchocerca volvulus 0.0095 0.0856 0.1133
Trypanosoma cruzi DNA topoisomerase II, putative 0.0059 0.0439 0.2358
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0145 0.1415 0.7629
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.004 0.0219 0.0268
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0299 0.3167 0.3167
Schistosoma mansoni hypothetical protein 0.0297 0.3154 0.3154
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0215 0.307
Loa Loa (eye worm) hypothetical protein 0.0145 0.1415 0.1731
Echinococcus multilocularis ubiquitin specific protease 41 0.0126 0.1199 0.1199
Brugia malayi Nuclear hormone receptor-like 1 0.0299 0.3167 0.3874
Echinococcus granulosus neuroligin 0.0095 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0041 0.0237 0.029
Onchocerca volvulus 0.0268 0.2823 0.4073
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0299 0.3167 0.3874
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0079 0.0668 0.3595
Brugia malayi hypothetical protein 0.0029 0.0098 0.012
Loa Loa (eye worm) hypothetical protein 0.0617 0.6788 0.8306
Brugia malayi methionyl-tRNA synthetase 0.0022 0.0025 0.003
Loa Loa (eye worm) hypothetical protein 0.0145 0.1423 0.174
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0143 0.0759
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0137 0.1327 0.1327
Schistosoma mansoni cpg binding protein 0.0096 0.0862 0.0862
Loa Loa (eye worm) hypothetical protein 0.004 0.0219 0.0268
Schistosoma mansoni laminin gamma-3 chain 0.0052 0.0358 0.0358
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0258 0.0258
Treponema pallidum sodium- and chloride- dependent transporter 0.017 0.1703 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0137 0.1327 0.1327
Brugia malayi Carboxylesterase family protein 0.0095 0.0856 0.1047
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0029 0.0098 0.0098
Leishmania major cytochrome p450-like protein 0.0027 0.0076 0.0394
Entamoeba histolytica hypothetical protein 0.0115 0.108 0.5286
Echinococcus multilocularis sodium and chloride dependent glycine 0.0029 0.0098 0.0098
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0162 0.161 0.161
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0174 0.0174
Echinococcus multilocularis musashi 0.0085 0.0738 0.0738
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0065 0.0514 0.0629
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0087 0.0452
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0174 0.0174
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.017 0.1703 0.1703
Schistosoma mansoni nuclear receptor 0.0137 0.1327 0.1327
Echinococcus granulosus dna polymerase kappa 0.0043 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0044 0.0269 0.0329
Echinococcus multilocularis acetylcholinesterase 0.0565 0.6198 0.6198
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0095 0.0856 0.0856
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0288 0.0353
Brugia malayi Inositol-1 0.0039 0.0215 0.0263
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0299 0.3167 0.3167
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0029 0.0098 0.0098
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.1922 0.2351
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0029 0.0098 0.0098
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0258 0.0258
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.0192 0.0965
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.1922 0.1922
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0022 0.0025 0.0122
Loa Loa (eye worm) hypothetical protein 0.0043 0.0258 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0013
Schistosoma mansoni hypothetical protein 0.0083 0.071 0.071
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0263 0.1407
Toxoplasma gondii methionyl-tRNA synthetase 0.0059 0.0438 0.2506
Loa Loa (eye worm) hypothetical protein 0.0029 0.0099 0.0121
Brugia malayi Carboxylesterase family protein 0.0565 0.6198 0.7584
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0029 0.0098 0.0098
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0739 0.8173 0.8173
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.049 0.049
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0299 0.3167 0.3874
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0126 0.1199 0.6461
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.049 0.2588
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0108
Loa Loa (eye worm) hypothetical protein 0.0137 0.1327 0.1623
Loa Loa (eye worm) hypothetical protein 0.0137 0.1327 0.1623
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0047 0.0309 0.0316
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0021 0.0011 0.0013
Plasmodium falciparum importin beta, putative 0.0028 0.0087 0.1258
Echinococcus multilocularis methionine tRNA synthetase 0.0059 0.0438 0.0438
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0021 0.0011 0.0013
Treponema pallidum exodeoxyribonuclease (exoA) 0.0079 0.0668 0.3871
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0021 0.0011 0.0038
Schistosoma mansoni cpg binding protein 0.0096 0.0862 0.0862
Toxoplasma gondii tRNA ligases class I (M) protein 0.0022 0.0025 0.0127
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0011 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.003
Trypanosoma brucei unspecified product 0.0036 0.0184 0.0979
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0004 0.0013
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0087 0.0481
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0357 0.1912
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0126 0.1199 0.6461
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0004 0.0013
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0263 0.1353
Brugia malayi Nuclear hormone receptor E75 0.0137 0.1327 0.1623
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0027 0.0076 0.0333
Schistosoma mansoni hypothetical protein 0.0083 0.071 0.071
Schistosoma mansoni RAR-like nuclear receptor 0.0299 0.3167 0.3167
Onchocerca volvulus 0.0036 0.0183 0.0128
Leishmania major lanosterol synthase, putative 0.0134 0.129 0.6956
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0137 0.1327 0.1327
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0194 0.1975 0.1975
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0137 0.1327 0.1623
Brugia malayi Cytochrome P450 family protein 0.0048 0.032 0.0391
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0498 0.0498
Echinococcus granulosus nuclear receptor nhr 48 0.0137 0.1327 0.1327
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0126 0.1199 0.1199
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0299 0.3167 0.3874
Echinococcus granulosus FTZ F1 alpha 0.0299 0.3167 0.3167
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0565 0.6198 0.6198
Brugia malayi hypothetical protein 0.0162 0.161 0.1969
Brugia malayi protein ZK524.3 0.0022 0.0025 0.003
Echinococcus multilocularis expressed conserved protein 0.0188 0.1905 0.1905
Echinococcus granulosus GPCR family 2 0.0064 0.0498 0.0498
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0263 0.1407
Schistosoma mansoni hypothetical protein 0.0064 0.0498 0.0498
Echinococcus granulosus neurogenic locus notch protein 0.0052 0.0358 0.0358
Brugia malayi Sodium:neurotransmitter symporter family protein 0.017 0.1703 0.2084
Trichomonas vaginalis DNA topoisomerase II, putative 0.0065 0.0514 0.1821
Echinococcus multilocularis sodium and chloride dependent glycine 0.0029 0.0098 0.0098
Echinococcus granulosus arachidonate 5 lipoxygenase 0.012 0.1138 0.1138
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0021 0.0011 0.0052
Brugia malayi CHE-14 protein 0.0145 0.1423 0.174
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0029 0.0098 0.0546
Loa Loa (eye worm) doublecortin family protein 0.0043 0.0258 0.0316
Loa Loa (eye worm) hypothetical protein 0.0565 0.6198 0.7584
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0022 0.0025 0.0056
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0157 0.1559 0.84
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0288 0.0353
Echinococcus multilocularis acetylcholinesterase 0.0565 0.6198 0.6198
Echinococcus granulosus Polycystic kidney disease protein 0.0043 0.0258 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0013
Schistosoma mansoni nuclear hormone receptor 0.0137 0.1327 0.1327
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.004 0.004
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0258 0.0258
Schistosoma mansoni sodium-dependent amino acid transporter 0.0029 0.0098 0.0098
Schistosoma mansoni coup transcription factor 0.0299 0.3167 0.3167
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0192 0.1022
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0021 0.0011 0.0045
Leishmania major farnesyltransferase beta subunit 0.0021 0.0011 0.0042
Schistosoma mansoni rab6-interacting 0.0043 0.0258 0.0258
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.032 0.0391
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0021 0.0011 0.0118
Toxoplasma gondii hypothetical protein 0.0029 0.0098 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0263 0.1407
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0021 0.0011 0.0011
Echinococcus multilocularis FTZ F1 alpha 0.0299 0.3167 0.3167
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0299 0.3167 0.3874
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0157 0.1559 0.84
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0059 0.0438 0.2353
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0011 0.0038
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0065 0.0514 0.0629
Echinococcus multilocularis neurogenic locus notch protein 0.0052 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0029 0.0099 0.0121
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0095 0.0856 0.3032
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0157 0.1559 0.84
Schistosoma mansoni nuclear hormone receptor 0.0299 0.3167 0.3167
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0157 0.1559 0.84
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0192 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0299 0.3167 0.3874
Echinococcus multilocularis nuclear receptor nhr 48 0.0137 0.1327 0.1327
Schistosoma mansoni steroid hormone receptor ad4bp 0.0299 0.3167 0.3167
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0739 0.8173 1
Schistosoma mansoni thyroid hormone receptor 0.0445 0.4837 0.4837
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0157 0.1559 0.84
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0215 0.0762
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0157 0.1559 0.84
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.003
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0162 0.161 0.1969
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.0106
Chlamydia trachomatis methionine--tRNA ligase 0.0022 0.0025 0.0648
Loa Loa (eye worm) hypothetical protein 0.0299 0.3167 0.3874
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0005 0.0005
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0003 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0184 0.0979
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0005 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.049 0.2588
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0137 0.1327 0.1327
Loa Loa (eye worm) DR-78 0.0137 0.1327 0.1623
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0299 0.3167 0.3167
Schistosoma mansoni sodium/chloride dependent transporter 0.0029 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0095 0.0856 0.1047
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0498 0.0498
Leishmania major DNA topoisomerase ii 0.0059 0.0439 0.2358
Echinococcus granulosus sodium and chloride dependent glycine 0.0029 0.0098 0.0098
Brugia malayi Cytochrome P450 family protein 0.0037 0.0192 0.0235
Trypanosoma cruzi DNA topoisomerase II, putative 0.0059 0.0439 0.2358
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0183 0.1854 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0899 1 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.004 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0011 0.0042
Echinococcus granulosus serotonin transporter 0.017 0.1703 0.1703
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0157 0.1559 0.84
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0563 0.3028
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0029 0.0098 0.0098
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0531 0.065
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0145 0.1415 0.1731
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0299 0.3167 0.3167
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0162 0.161 0.161
Schistosoma mansoni hypothetical protein 0.0064 0.0498 0.0498
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0027 0.0076 0.0333
Trypanosoma cruzi protein farnesyltransferase, putative 0.0021 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0137 0.1327 0.1623
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0079 0.0668 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0126 0.1199 0.4246
Onchocerca volvulus 0.0095 0.0856 0.1133
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0215 0.1222
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0079 0.0668 0.3595
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0157 0.1559 0.84
Plasmodium vivax DNA topoisomerase II, putative 0.0065 0.0514 0.7685
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.049 0.2634
Brugia malayi Cytochrome P450 family protein 0.0037 0.0192 0.0235
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0357 0.1912
Brugia malayi nuclear receptor RXR 0.0162 0.161 0.1969
Brugia malayi hypothetical protein 0.0043 0.0258 0.0316
Mycobacterium leprae putative cytochrome p450 0.0157 0.1559 1
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0531 0.065
Loa Loa (eye worm) hypothetical protein 0.02 0.2043 0.25
Brugia malayi follicle stimulating hormone receptor 0.0252 0.2641 0.3232
Loa Loa (eye worm) hypothetical protein 0.0565 0.6198 0.7584
Loa Loa (eye worm) hypothetical protein 0.0162 0.161 0.1969
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0145 0.1415 0.1415
Brugia malayi Probable DNA topoisomerase II 0.0065 0.0514 0.0629
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0079 0.0668 0.3554
Brugia malayi cytochrome P450 0.0027 0.0076 0.0093
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0357 0.1264
Loa Loa (eye worm) hypothetical protein 0.0299 0.3167 0.3874
Loa Loa (eye worm) hypothetical protein 0.0137 0.1327 0.1623
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0174 0.0174
Schistosoma mansoni hypothetical protein 0.0027 0.0076 0.0076
Brugia malayi orphan nuclear receptor NR2E1 0.0137 0.1327 0.1623
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.012 0.1138 0.1138
Schistosoma mansoni nuclear hormone receptor 0.0137 0.1327 0.1327
Schistosoma mansoni slit 0.0052 0.0358 0.0358
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0036 0.0183 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0143 0.0759
Schistosoma mansoni lipoxygenase 0.0043 0.0258 0.0258
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.004 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0299 0.3167 0.3874
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0174 0.0985
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0047 0.0309 0.0316
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0022 0.0025 0.0158
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0263 0.1407
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0215 0.1091
Echinococcus granulosus cytochrome P450 2K1 0.0027 0.0076 0.0076
Leishmania major cytochrome p450-like protein 0.0037 0.0192 0.1022
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0095 0.0856 0.0856
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0052 0.0358 0.0438
Schistosoma mansoni zinc finger protein 0.0137 0.1327 0.1327
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0215 0.0215
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0137 0.1327 0.1623
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0079 0.0668 0.3595
Schistosoma mansoni DNA topoisomerase II 0.0065 0.0514 0.0514
Echinococcus granulosus acetylcholinesterase 0.0565 0.6198 0.6198
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0021 0.0011 0.0038
Echinococcus multilocularis expressed protein 0.0394 0.4258 0.4258
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0004 0.0013
Onchocerca volvulus Protein ultraspiracle homolog 0.0299 0.3167 0.4587
Brugia malayi tailless protein 0.0137 0.1327 0.1623
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0029 0.0098 0.012
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0162 0.161 0.161
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0157 0.1559 0.84
Trypanosoma cruzi lanosterol synthase, putative 0.0155 0.1531 0.8259
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0029 0.0098 0.012
Echinococcus granulosus Niemann Pick C1 protein 0.0345 0.3696 0.3696
Trypanosoma cruzi lanosterol synthase, putative 0.0155 0.1531 0.8259
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0299 0.3167 0.3167
Echinococcus multilocularis BC026374 protein (S09 family) 0.0095 0.0856 0.0856
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0258 0.0258
Plasmodium falciparum DNA gyrase subunit B 0.0022 0.0015 0.0176
Schistosoma mansoni nuclear receptor nhr-48 0.0137 0.1327 0.1327
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0005 0.0005
Onchocerca volvulus 0.0095 0.0856 0.1133
Echinococcus granulosus RUN 0.0043 0.0258 0.0258
Schistosoma mansoni intermediate filament proteins 0.0085 0.0738 0.0738
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0013
Leishmania major methionyl-tRNA synthetase, putative 0.0059 0.0438 0.2353
Brugia malayi nuclear receptor RXR 0.0137 0.1327 0.1623
Loa Loa (eye worm) hypothetical protein 0.0137 0.1327 0.1623
Loa Loa (eye worm) hypothetical protein 0.017 0.1703 0.2084
Brugia malayi Carboxylesterase family protein 0.0095 0.0856 0.1047
Echinococcus multilocularis muscleblind protein 0.0158 0.1572 0.1572
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0299 0.3167 0.3167
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0498 0.061
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0237 0.0237
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0126 0.1199 0.1199
Onchocerca volvulus 0.0137 0.1327 0.1837
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0095 0.0856 0.4574
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0003 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.2073 0.2536
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0157 0.1559 0.84
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0157 0.1559 0.84
Chlamydia trachomatis leucine--tRNA ligase 0.0022 0.0025 0.0648
Loa Loa (eye worm) norepinephrine transporter 0.017 0.1703 0.2084
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0065 0.0514 0.0514
Loa Loa (eye worm) hypothetical protein 0.0138 0.1344 0.1645
Loa Loa (eye worm) serotonin transporter b 0.017 0.1703 0.2084
Brugia malayi small heat shock protein 0.061 0.6715 0.8215
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0192 0.0235
Onchocerca volvulus 0.0085 0.0738 0.0957
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0126 0.1199 0.6461
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0263 0.1353
Echinococcus granulosus muscleblind protein 0.0158 0.1572 0.1572
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.049 0.049
Echinococcus multilocularis protein dispatched 1 0.0157 0.156 0.156
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0174 0.0174
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.108 0.108
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0215 0.0762
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.1922 0.1922
Entamoeba histolytica DNA topoisomerase II, putative 0.0065 0.0514 0.2516
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0263 0.1407
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0299 0.3167 0.3167
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0157 0.1559 0.84
Loa Loa (eye worm) hypothetical protein 0.0137 0.1327 0.1623
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0044 0.0269 0.0329
Onchocerca volvulus 0.0091 0.0803 0.1054
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0029 0.0098 0.0098
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0563 0.3028
Echinococcus granulosus Protein patched homolog 1 0.0145 0.1423 0.1423
Echinococcus multilocularis Niemann Pick C1 protein 0.02 0.2043 0.2043
Leishmania major importin beta-1 subunit, putative 0.0023 0.0027 0.0128
Brugia malayi hypothetical protein 0.0137 0.1327 0.1623
Echinococcus granulosus ecdysone induced protein 78C 0.0299 0.3167 0.3167
Schistosoma mansoni methionine-tRNA synthetase 0.0059 0.0438 0.0438
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0027 0.0128
Loa Loa (eye worm) acetylcholinesterase 1 0.0565 0.6198 0.7584
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0021 0.0011 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1922 0.1922
Brugia malayi Carboxylesterase family protein 0.0565 0.6198 0.7584
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0145 0.1415 0.1415
Trichomonas vaginalis ran, putative 0.0021 0.0003 0.001
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0027 0.0076 0.0333
Chlamydia trachomatis DNA gyrase subunit B 0.0036 0.0174 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.1327 0.1623
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0357 0.0357
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0126 0.1199 0.6461
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.049 0.2588
Loa Loa (eye worm) hypothetical protein 0.0126 0.1199 0.1466
Echinococcus granulosus microtubule associated protein 2 0.0805 0.8925 0.8925
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0047 0.0309 0.0316
Schistosoma mansoni lamin 0.0085 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0105 0.0965 0.118
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0192 0.1022
Trypanosoma brucei DNA topoisomerase ii 0.0051 0.0355 0.1903
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.049 0.2805
Brugia malayi hypothetical protein 0.0095 0.0856 0.1047
Brugia malayi conserved hypotetical protein 0.0137 0.1327 0.1623
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0126 0.1199 0.4246
Plasmodium vivax importin-beta 2, putative 0.0028 0.0087 0.1258
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0021 0.0011 0.0038
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1102 0.1349

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 49 mg kg-1 Anticonvulsant activity tested by maximal metrazole seizure (MMS) test in mouse after 1 hr of administration ChEMBL. 3783589
ED50 (functional) = 51 mg kg-1 Anticonvulsant activity tested by maximal electroshock test (MES) in mouse after 1 hr of administration ChEMBL. 3783589
TD50 (ADMET) = 317 mg kg-1 Neurotoxicity of the compound was tested by performing a rotorod test in mouse after 1 hr of administration ChEMBL. 3783589

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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