Detailed information for compound 1269640

Basic information

Technical information
  • TDR Targets ID: 1269640
  • Name: [3-(cyanomethyl)-4-oxoquinazolin-2-yl]methyl 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfan yl]acetate
  • MW: 398.436 | Formula: C19H18N4O4S
  • H donors: 0 H acceptors: 4 LogP: 2 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCn1c(COC(=O)CSCc2c(C)noc2C)nc2c(c1=O)cccc2
  • InChi: 1S/C19H18N4O4S/c1-12-15(13(2)27-22-12)10-28-11-18(24)26-9-17-21-16-6-4-3-5-14(16)19(25)23(17)8-7-20/h3-6H,8-11H2,1-2H3
  • InChiKey: WASAVKZVMDGIRK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [3-(cyanomethyl)-4-oxo-quinazolin-2-yl]methyl 2-[(3,5-dimethylisoxazol-4-yl)methylsulfanyl]acetate
  • 2-[(3,5-dimethyl-4-isoxazolyl)methylthio]acetic acid [3-(cyanomethyl)-4-oxo-2-quinazolinyl]methyl ester
  • 2-[(3,5-dimethylisoxazol-4-yl)methylthio]acetic acid [3-(cyanomethyl)-4-keto-quinazolin-2-yl]methyl ester
  • [3-(cyanomethyl)-4-oxo-quinazolin-2-yl]methyl 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]ethanoate
  • ZINC03452530
  • T5347275
  • MLS000048391
  • SMR000064819

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0076 0.0804
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.003 0.0076
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.003 0.0776
Trichomonas vaginalis rotamase, putative 0.0039 0.0085 0.0965
Brugia malayi MH2 domain containing protein 0.0016 0.0015 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0214
Schistosoma mansoni inositol monophosphatase 0.0036 0.0076 0.0271
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.039 0.038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0119 0.0108
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0011 0.0004
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0024 0.0713
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0076 0.0856
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0358
Onchocerca volvulus 0.0029 0.0053 0.0575
Loa Loa (eye worm) hypothetical protein 0.0045 0.0102 0.03
Loa Loa (eye worm) inositol-1 0.0036 0.0076 0.0223
Schistosoma mansoni sugar transporter 0.0052 0.0122 0.0458
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.0102 0.0273
Brugia malayi PAS domain containing protein 0.0048 0.0112 0.0302
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.0833 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0076 0.3323
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0024 0.006
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0274 0.0783 0.2583
Brugia malayi Major Facilitator Superfamily protein 0.0052 0.0122 0.0331
Brugia malayi nuclear hormone receptor family member odr-7 0.0021 0.0031 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0337 0.1341
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.025 0.2959
Onchocerca volvulus Huntingtin homolog 0.0121 0.0327 0.3834
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0023 0.0112
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0085 0.022 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0065 0.0178
Brugia malayi ecdysone receptor 0.0021 0.0031 0.0063
Brugia malayi hypothetical protein 0.0052 0.0122 0.0331
Brugia malayi hypothetical protein 0.0052 0.0122 0.0331
Leishmania major glucose transporter/membrane transporter D2, putative 0.0052 0.0122 0.3465
Trypanosoma brucei glucose transporter 2A 0.0052 0.0122 0.3465
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0039 0.0118
Onchocerca volvulus 0.0052 0.0122 0.1388
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0023 0.0549
Trypanosoma brucei glucose transporter, putative 0.0052 0.0122 0.3465
Brugia malayi Cytochrome P450 family protein 0.0036 0.0075 0.0193
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0024 0.0713
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.003 0.002
Onchocerca volvulus 0.0052 0.0122 0.1388
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0014 0.001 0.0163
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0024 0.01
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0036 0.0075 0.0064
Loa Loa (eye worm) hypothetical protein 0.0054 0.0127 0.0375
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0077 0.0276
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0085 0.248
Toxoplasma gondii sugar transporter ST1 0.0052 0.0122 0.5435
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0024 0.0597
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.001 0.0256
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0052 0.0122 0.1014
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.003 0.0252
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0085 0.0914
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0031 0.0087
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.003 0.002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0076 0.2216
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0063 0.0256
Brugia malayi MH1 domain containing protein 0.0016 0.0015 0.0016
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0077 0.0254
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0077 0.2155
Brugia malayi calpain 5 0.0019 0.0024 0.0043
Mycobacterium leprae putative cytochrome p450 0.0036 0.0075 0.0209
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0358
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0036 0.0075 0.0584
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0039 0.0086
Trypanosoma brucei sugar transporter, putative 0.0052 0.0122 0.3465
Toxoplasma gondii facilitative glucose transporter GT1 0.0052 0.0122 0.5435
Echinococcus multilocularis Ankyrin 0.0014 0.0011 0.0043
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0024 0.006
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0014 0.001 0.0163
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.025 0.0985
Toxoplasma gondii cytochrome p450 superfamily protein 0.0036 0.0075 0.3272
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0268 0.0791
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0009 0.0256
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.003 0.0776
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.003 0.0182
Onchocerca volvulus 0.0045 0.0102 0.1151
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0085 0.248
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0384 0.1112 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0039 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.0667 0.1969
Echinococcus multilocularis nuclear receptor nhr 48 0.0021 0.0031 0.0127
Schistosoma mansoni Replicative DNA helicase 0.0384 0.1112 0.4516
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.025 0.7295
Echinococcus multilocularis smad 0.0016 0.0015 0.0062
Giardia lamblia Hexose transporter 0.0052 0.0122 0.1361
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.0102 0.0273
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0111 0.0366
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0063 0.0157
Echinococcus granulosus abhydrolase domain containing protein 0.0038 0.008 0.0263
Trypanosoma brucei glucose transporter, putative 0.0052 0.0122 0.3465
Trichomonas vaginalis glucose transporter, putative 0.0052 0.0122 0.1406
Schistosoma mansoni jun-related protein 0.0068 0.017 0.0656
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Echinococcus granulosus geminin 0.0504 0.1468 0.4839
Echinococcus granulosus thyroid hormone receptor alpha 0.0021 0.0031 0.0102
Brugia malayi AMP-binding enzyme family protein 0.0021 0.003 0.0061
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.001 0.0042
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0121 0.3444
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0027
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0065 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0071 0.0798
Brugia malayi P38 map kinase family protein 2 0.0126 0.0343 0.0986
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0076 0.0594
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0111 0.0414
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0102 0.0273
Trichomonas vaginalis myo-inositol transporter, putative 0.0052 0.0122 0.1406
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0071 0.0746
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.0664 0.1958
Loa Loa (eye worm) hypothetical protein 0.1148 0.3387 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0358
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0358
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0024 0.0597
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0005 0.0014
Echinococcus multilocularis solute carrier family 22 0.0052 0.0122 0.0496
Loa Loa (eye worm) acetyltransferase 0.0288 0.0826 0.2437
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.025 0.2959
Trypanosoma cruzi sugar transporter, putative 0.0052 0.0122 0.3545
Brugia malayi bZIP transcription factor family protein 0.0083 0.0216 0.0611
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0052 0.0122 0.0496
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0288 0.0826 0.3371
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0126 0.0371
Trichomonas vaginalis glucose transporter, putative 0.0052 0.0122 0.1406
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.003 0.1217
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.0102 0.0416
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0067 0.0168 0.0554
Schistosoma mansoni hypothetical protein 0.0052 0.0122 0.0458
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.025 0.7262
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0056 0.019
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0036 0.0075 0.0064
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0004 0.0123
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0182 0.1553
Brugia malayi TAR-binding protein 0.0124 0.0337 0.0969
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0036 0.0075 0.2184
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0024 0.0597
Giardia lamblia ABC transporter, putative 0.0014 0.001 0.0004
Onchocerca volvulus Huntingtin homolog 0.0121 0.0327 0.3834
Echinococcus multilocularis transcription factor btf3 0.0035 0.0071 0.0291
Echinococcus granulosus tar DNA binding protein 0.0124 0.0337 0.1111
Echinococcus granulosus hypothetical protein 0.0692 0.2029 0.6692
Treponema pallidum replicative DNA helicase (dnaB) 0.0384 0.1112 1
Plasmodium vivax calpain, putative 0.0019 0.0024 0.0082
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.0102 0.1155
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0023 0.0012
Brugia malayi Uncoordinated protein 44 0.0014 0.001 0.0001
Onchocerca volvulus 0.0021 0.003 0.0302
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.039 0.1155
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0056 0.019
Loa Loa (eye worm) hypothetical protein 0.0054 0.0127 0.0375
Schistosoma mansoni glucose transport protein 0.0052 0.0122 0.0458
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.0031 0.0309
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0182 0.5238
Schistosoma mansoni sugar transporter 0.0052 0.0122 0.0458
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0031 0.0127
Echinococcus multilocularis mitogen activated protein kinase 11 0.0126 0.0343 0.1399
Brugia malayi acetyltransferase, GNAT family protein 0.0288 0.0826 0.2416
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.025 0.292
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0015 0.0044
Schistosoma mansoni hydrolase 0.0038 0.008 0.0287
Schistosoma mansoni hypothetical protein 0.0068 0.017 0.0656
Onchocerca volvulus 0.0052 0.0122 0.1388
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0024 0.0597
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.0102 0.0416
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0182 0.1553
Toxoplasma gondii exonuclease III APE 0.0019 0.0023 0.0861
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0088 0.0999
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.0833 1
Leishmania major cytochrome p450-like protein 0.0036 0.0075 0.2086
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0071 0.2746
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.003 0.002
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Leishmania major myo-inositol/proton symporter (MIT) 0.0052 0.0122 0.3465
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0077 0.0276
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0113
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.245 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.001 0.003
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.003 0.089
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Brugia malayi hypothetical protein 0.0021 0.0031 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.0102 0.0336
Schistosoma mansoni smad1 5 8 and 0.0016 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0064 0.0158 0.0467
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0358
Echinococcus granulosus netrin receptor unc 5 0.0014 0.001 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0122 0.1406
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Mycobacterium leprae Conserved hypothetical protein 0.0036 0.0075 0.0209
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0012 0.0004 0.0123
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.0102 0.0336
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0091
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0023 0.0163
Echinococcus granulosus histone acetyltransferase KAT2B 0.0085 0.022 0.0726
Onchocerca volvulus 0.0031 0.006 0.0652
Echinococcus granulosus Smad4 0.0016 0.0015 0.005
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.003 0.002
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0052 0.0122 0.1059
Giardia lamblia Histone acetyltransferase GCN5 0.0078 0.0199 0.2302
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0005 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0122 0.1406
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0052 0.0122 0.0458
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.003 0.0182
Trypanosoma cruzi hexose transporter, putative 0.0052 0.0122 0.3545
Trypanosoma brucei multidrug resistance protein E 0.0014 0.001 0.0163
Brugia malayi Cytochrome P450 family protein 0.0036 0.0075 0.0193
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0294 0.0844 0.247
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0102 0.0378
Plasmodium vivax hexose transporter 0.0052 0.0122 0.5004
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0014 0.001 0.0016
Trypanosoma brucei polo-like protein kinase 0.0095 0.025 0.7262
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0052 0.0122 0.0111
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.003 0.089
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0024 0.0713
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0036 0.0075 0.0064
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0036 0.0075 0.0584
Echinococcus granulosus calpain 5 0.0019 0.0024 0.0081
Onchocerca volvulus 0.0052 0.0122 0.1388
Trichomonas vaginalis set domain proteins, putative 0.0235 0.0669 0.8019
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0021 0.0031 0.0091
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.0102 0.0378
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0126 0.0343 1
Onchocerca volvulus 0.0021 0.003 0.0302
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0066 0.1927
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0121 0.0493
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0067 0.0168 0.0686
Trypanosoma brucei protein kinase, putative 0.0051 0.0121 0.3444
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0031 0.0087
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.001 0.0004
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3091 0.9175 0.9175
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0036 0.0075 0.0064
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0052 0.0122 0.0496
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.003 0.0089
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0063 0.0207
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0121 0.0398
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0015 0.0062
Plasmodium falciparum epoxide hydrolase 1 0.0038 0.008 0.3231
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0182 0.1553
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Trichomonas vaginalis rotamase, putative 0.004 0.0088 0.0999
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0182 0.1553
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.001 0.0002
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.003 0.0182
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Schistosoma mansoni rotamase 0.004 0.0088 0.032
Loa Loa (eye worm) hypoxia-induced factor 1 0.015 0.0413 0.122
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0091
Brugia malayi N-terminal motif family protein 0.0179 0.0502 0.1458
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0081 0.0208 0.0813
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0054
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0182 0.1553
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0077 0.0254
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.0102 0.1155
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0036 0.0075 0.0064
Loa Loa (eye worm) calpain family protein 1 0.0045 0.0102 0.0299
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.003 0.0061
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0013
Echinococcus granulosus inhibitor of apoptosis protein 0.0081 0.0208 0.0686
Schistosoma mansoni transcription factor btf3 0.0035 0.0071 0.0252
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.0549
Echinococcus multilocularis geminin 0.0504 0.1468 0.599
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0005 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.003 0.0182
Brugia malayi Pre-SET motif family protein 0.003 0.0056 0.0137
Loa Loa (eye worm) hydrolase 0.0038 0.008 0.0234
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0023 0.0093
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.003 0.0776
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0033 0.0096
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0077 0.2251
Echinococcus multilocularis calpain 5 0.0019 0.0024 0.01
Echinococcus granulosus Solute carrier family 22 5 0.1029 0.3032 1
Loa Loa (eye worm) TAR-binding protein 0.0124 0.0337 0.0994
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.0102 0.03
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0024 0.0713
Onchocerca volvulus 0.0052 0.0122 0.1388
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0085 0.3743
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0102 0.0273
Echinococcus multilocularis musashi 0.0027 0.0048 0.0194
Echinococcus granulosus Ankyrin 0.0014 0.0011 0.0035
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0121 0.1398
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.003 0.0182
Leishmania major hypothetical protein, conserved 0.0052 0.0122 0.3465
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0071 0.2077
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0031 0.0102
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0036 0.0075 0.0064
Trichomonas vaginalis sugar transport protein, putative 0.0052 0.0122 0.1406
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0045 0.0102 0.0336
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0021 0.0031 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0337 0.1341
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0182 0.5238
Brugia malayi hypothetical protein 0.0024 0.0039 0.0086
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0036 0.0075 0.0584
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0052 0.0122 0.0401
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0036 0.0075 0.0064
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0268 0.0765
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0077 0.0315
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0053 0.0174
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.025 0.7295
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0005 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Echinococcus multilocularis lamin dm0 0.0027 0.0048 0.0194
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0036 0.0075 0.0584
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.003 0.0182
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.001 0.0001
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0085 0.022 1
Brugia malayi orphan nuclear receptor NR2E1 0.0021 0.0031 0.0063
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0014
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0005 0.015
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0071 0.1978
Mycobacterium ulcerans sugar transporter 0.0052 0.0122 0.1008
Echinococcus granulosus smad 0.0016 0.0015 0.005
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0182 0.0171
Brugia malayi Cytochrome P450 family protein 0.0036 0.0075 0.0193
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.003 0.0182
Echinococcus multilocularis calpain A 0.0067 0.0168 0.0686
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0006 0.0025
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0067 0.0168 0.0649
Trypanosoma brucei glucose transporter, putative 0.0052 0.0122 0.3465
Brugia malayi Smad1 0.0016 0.0015 0.0016
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0031 0.0063
Schistosoma mansoni glucose transporter 0.0052 0.0122 0.0458
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.025 0.2959
Leishmania major protein kinase, putative 0.0018 0.002 0.0475
Trypanosoma brucei THT1 - hexose transporter, putative 0.0052 0.0122 0.3465
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0337 0.1341
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0186 0.0612
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0063 0.0207
Loa Loa (eye worm) hypothetical protein 0.0045 0.0102 0.03
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0182 0.1553
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.0337 0.0994
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0274 0.0783 0.3198
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0021 0.0031 0.0087
Schistosoma mansoni nuclear receptor nhr-48 0.0021 0.0031 0.0087
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.025 0.2919
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Onchocerca volvulus 0.0052 0.0122 0.1388
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0149 0.1257
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0126 0.0343 1
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0024 0.0081
Schistosoma mansoni sugar transporter 0.0052 0.0122 0.0458
Echinococcus granulosus nuclear receptor nhr 48 0.0021 0.0031 0.0102
Onchocerca volvulus Deterin homolog 0.0294 0.0844 1
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0337 0.1341
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0358
Brugia malayi Sugar transporter family protein 0.0052 0.0122 0.0331
Schistosoma mansoni hypothetical protein 0.0504 0.1468 0.5974
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0091
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.003 0.089
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0126 0.0343 0.1011
Loa Loa (eye worm) hypothetical protein 0.0072 0.0182 0.0535
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0127 0.0117
Echinococcus multilocularis multidrug resistance associated protein 7 0.0014 0.001 0.004
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0121 0.1353
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.0102 0.0378
Echinococcus multilocularis tar DNA binding protein 0.0124 0.0337 0.1375
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.003 0.002
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0036 0.0075 0.0584
Plasmodium falciparum histone acetyltransferase GCN5 0.0078 0.0199 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0113
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0052 0.0122 0.1008
Brugia malayi AMP-binding enzyme family protein 0.0021 0.003 0.0061
Echinococcus multilocularis solute carrier family 22 0.0052 0.0122 0.0496
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0149 0.1257
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.0102 0.0273
Echinococcus multilocularis thyroid hormone receptor alpha 0.0045 0.0102 0.0416
Brugia malayi intermediate filament protein 0.0027 0.0048 0.0112
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.0102 0.1155
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0036 0.0075 0.0064
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0076 0.2119
Onchocerca volvulus 0.0021 0.0031 0.0309
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.003 0.002
Brugia malayi MH2 domain containing protein 0.0234 0.0664 0.1936
Brugia malayi AMP-binding enzyme family protein 0.0021 0.003 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.003 0.0182
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Echinococcus granulosus synaptic vesicle 2 protein 0.0052 0.0122 0.0403
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.0833 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0036 0.0075 0.0064
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0015 0.0022
Echinococcus multilocularis abhydrolase domain containing protein 0.0038 0.008 0.0326
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0076 0.025
Onchocerca volvulus 0.0072 0.0182 0.2103
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0036 0.0075 0.0584
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.0102 0.0273
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0121 0.0455
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0091
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0214
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0076 0.0856
Trypanosoma brucei glucose transporter, putative 0.0052 0.0122 0.3465
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0039 0.0118
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.003 0.0776
Echinococcus multilocularis mitogen activated protein kinase 14 0.0126 0.0343 0.1399
Trypanosoma brucei kinesin, putative 0.0019 0.0024 0.0597
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.0833 1
Chlamydia trachomatis replicative DNA helicase 0.0384 0.1112 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0165
Echinococcus multilocularis expressed protein 0.004 0.0088 0.0359
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0127 0.5307
Brugia malayi nuclear hormone receptor family member nhr-6 0.0021 0.0031 0.0063
Schistosoma mansoni retinoic acid receptor RXR 0.0045 0.0102 0.0378
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0077 0.0315
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0024 0.0597
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.003 0.0124
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0113
Entamoeba histolytica hypothetical protein 0.0035 0.0071 0.0746
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0076 0.2119
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0024 0.0713
Schistosoma mansoni smad 0.0016 0.0015 0.0022
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.003 0.0435
Loa Loa (eye worm) hypothetical protein 0.0045 0.0102 0.03
Brugia malayi hydrolase, alpha/beta fold family protein 0.0038 0.008 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0122 0.1406
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0358
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0022 0.0011
Trypanosoma cruzi hexose transporter 0.0052 0.0122 0.3545
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0036 0.0075 0.0584
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0036 0.0075 0.0064
Schistosoma mansoni hypothetical protein 0.0032 0.0063 0.0217
Loa Loa (eye worm) hypothetical protein 0.0294 0.0844 0.2491
Mycobacterium ulcerans hypothetical protein 0.0072 0.0182 0.1553
Echinococcus multilocularis mitogen activated protein kinase 14 0.0126 0.0343 0.1399
Brugia malayi ecdysteroid receptor 0.0045 0.0102 0.0273
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0294 0.0844 0.2783
Giardia lamblia Kinase, PLK 0.0095 0.025 0.2922
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.001 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0122 0.1406
Chlamydia trachomatis recombinase RecA 0.0107 0.0287 0.2549
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0052 0.0122 0.0496
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0358
Brugia malayi hypothetical protein 0.0162 0.0451 0.1306
Schistosoma mansoni coup transcription factor 0.0045 0.0102 0.0378
Brugia malayi nuclear receptor NHR-67 0.0021 0.0031 0.0063
Schistosoma mansoni single-minded 0.0048 0.0112 0.0418
Loa Loa (eye worm) cytochrome P450 0.0036 0.0075 0.022
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0036 0.0075 0.0584
Loa Loa (eye worm) hypothetical protein 0.0179 0.0502 0.1481
Onchocerca volvulus 0.0052 0.0122 0.1388
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.025 0.2959
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0358
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0023 0.0075
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0091
Schistosoma mansoni kinase 0.0049 0.0113 0.0421
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0063 0.0184
Loa Loa (eye worm) hypothetical protein 0.0045 0.0102 0.0299
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.0833 1
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0066 0.1927
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.0102 0.0336
Brugia malayi nuclear receptor RXR 0.0024 0.0039 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.0102 0.0273
Entamoeba histolytica protein kinase, putative 0.002 0.0028 0.0223
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Mycobacterium leprae Conserved hypothetical protein 0.1132 0.3341 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0102 0.0416
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.001 0.0163
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.003 0.002
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.245 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0036 0.0075 0.0064
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0085 0.022 0.2596
Schistosoma mansoni intermediate filament proteins 0.0027 0.0048 0.0155
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0014 0.001 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.0102 0.0273
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0021 0.0031 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0102 0.0416
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0102 0.0378
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0121 0.3525
Onchocerca volvulus 0.0052 0.0122 0.1388
Echinococcus multilocularis calpain family protein 1, d 0.0045 0.0102 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0122 0.1406
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0023 0.0666
Loa Loa (eye worm) twinkle helicase 0.011 0.0295 0.0869
Loa Loa (eye worm) hypothetical protein 0.0054 0.0127 0.0375
Schistosoma mansoni lamin 0.0027 0.0048 0.0155
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.039 0.345
Schistosoma mansoni hypothetical protein 0.0504 0.1468 0.5974
Brugia malayi tailless protein 0.0021 0.0031 0.0063
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0111 0.0414
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0186 0.0758
Brugia malayi nuclear hormone receptor 0.0045 0.0102 0.0273
Schistosoma mansoni zinc finger protein 0.0021 0.0031 0.0087
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0036 0.0075 0.0584
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.0102 0.0378
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.003 0.0182
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0075 0.0584
Schistosoma mansoni nuclear receptor 0.0021 0.0031 0.0087
Loa Loa (eye worm) sugar transporter 0.0052 0.0122 0.0358
Brugia malayi small heat shock protein 0.1148 0.3387 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0127 0.1063
Giardia lamblia Fructose-bisphosphate aldolase 0.029 0.0833 1
Loa Loa (eye worm) hypothetical protein 0.0162 0.0451 0.133
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0005 0.0026
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.003 0.0089
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0052 0.0122 0.0401
Mycobacterium ulcerans integral membrane transport protein 0.0052 0.0122 0.1008
Treponema pallidum fructose-bisphosphate aldolase 0.029 0.0833 0.744
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.0664 0.1958
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.001 0.0002
Echinococcus multilocularis solute carrier family 22 0.0052 0.0122 0.0496
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Trypanosoma cruzi hexose transporter, putative 0.0052 0.0122 0.3545
Trypanosoma brucei THT1 - hexose transporter, putative 0.0052 0.0122 0.3465
Onchocerca volvulus 0.0021 0.003 0.0302
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Schistosoma mansoni hypothetical protein 0.0036 0.0075 0.0267
Echinococcus multilocularis calpain 0.0019 0.0024 0.01
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0121 0.5402
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.0337 0.0969
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0111 0.0299
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.001 0.0163
Brugia malayi hypothetical protein 0.0121 0.0327 0.0938
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0077 0.2155
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0102 0.0378
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0091
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0036 0.0075 0.0064
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.0102 0.0416
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0102 0.0273
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0036 0.0075 0.0064
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0006 0.0021
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0048 0.0112
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0182 0.0509
Brugia malayi hypoxia-induced factor 1 0.015 0.0413 0.1195
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.003 0.0306
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0102 0.0336
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0076 0.2216
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0031 0.006 0.1643
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0056 0.019
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0005 0.015
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.001 0.0004
Echinococcus granulosus jun protein 0.0083 0.0216 0.0713
Onchocerca volvulus 0.0027 0.0048 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0102 0.0273
Leishmania major hypothetical protein, conserved 0.0038 0.008 0.2231
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.003 0.089
Toxoplasma gondii sugar transporter ST3 0.0052 0.0122 0.5435
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0102 0.0273
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0024 0.0713
Schistosoma mansoni inhibitor of apoptosis protein 0.0081 0.0208 0.0813
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0036 0.0075 0.0584
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0039 0.0113
Loa Loa (eye worm) hypothetical protein 0.0101 0.0268 0.0791
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.025 0.2959
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0075 0.022
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0048 0.0139
Echinococcus multilocularis hypothetical protein 0.0019 0.0024 0.01
Brugia malayi nuclear hormone receptor 0.0021 0.0031 0.0063
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Brugia malayi Pre-SET motif family protein 0.0207 0.0584 0.17
Onchocerca volvulus 0.003 0.0056 0.0607
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.0502 0.5925
Loa Loa (eye worm) hypothetical protein 0.0064 0.0158 0.0467
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0077 0.0823
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0182 0.5238
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0122 0.1406
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0036 0.0075 0.0584
Echinococcus granulosus single minded 2 0.0036 0.0074 0.0245
Onchocerca volvulus 0.0027 0.0048 0.0506
Echinococcus granulosus microtubule associated protein 2 0.0833 0.245 0.8079
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.003
Schistosoma mansoni hypothetical protein 0.0032 0.0063 0.0217
Brugia malayi major facilitator superfamily protein 0.0052 0.0122 0.0331
Loa Loa (eye worm) major facilitator superfamily transporter 0.0052 0.0122 0.0358
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0029
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0077 0.087
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0077 0.087
Loa Loa (eye worm) hypothetical protein 0.0121 0.0327 0.0964
Toxoplasma gondii sugar transporter ST2 0.0052 0.0122 0.5435
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0077 0.0819
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0023 0.0159
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0121 0.0398
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.0031 0.0309
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0014 0.001 0.0163
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0064 0.0158 0.0609
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0149 0.057
Schistosoma mansoni cytochrome P450 0.0036 0.0075 0.0267
Echinococcus granulosus GPCR family 2 0.0032 0.0063 0.0207
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0056 0.0229
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.001 0.0034
Brugia malayi calpain 7 0.0019 0.0024 0.0043
Loa Loa (eye worm) oxidoreductase 0.0021 0.003 0.0089
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Loa Loa (eye worm) hypothetical protein 0.0045 0.0102 0.03
Echinococcus multilocularis mitogen activated protein kinase 11 0.0126 0.0343 0.1399
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0119 0.0108
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.003 0.0306
Loa Loa (eye worm) hypothetical protein 0.0045 0.0102 0.03
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.0102 0.0378
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0384 0.1112 0.3318
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Onchocerca volvulus 0.0052 0.0122 0.1388
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0028
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0036 0.0075 0.0064
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0028
Echinococcus granulosus calpain 0.0019 0.0024 0.0081
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0052 0.0122 0.0496
Echinococcus multilocularis GPCR, family 2 0.0032 0.0063 0.0256
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0067 0.0168 0.0649
Onchocerca volvulus 0.0066 0.0163 0.1881
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0121 0.1398
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0071 0.0798
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0056 0.0229
Brugia malayi Major Facilitator Superfamily protein 0.0052 0.0122 0.0331
Schistosoma mansoni hypothetical protein 0.0014 0.001 0.0002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0031 0.0127
Onchocerca volvulus 0.0021 0.0031 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0071 0.0798
Loa Loa (eye worm) hypothetical protein 0.0069 0.0173 0.051
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0107 0.0287 0.2555
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.0102 0.03
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0149 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.0102 0.0273
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0077 0.0254
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0091
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0182 0.0529
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.0102 0.0416
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0294 0.0844 0.3445
Trypanosoma cruzi glucose transporter, putative 0.0052 0.0122 0.3545
Brugia malayi hypothetical protein 0.0066 0.0163 0.0453
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.0102 0.03
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0052 0.0122 0.0496
Loa Loa (eye worm) hypothetical protein 0.0054 0.0127 0.0375
Trypanosoma cruzi hexose transporter, putative 0.0052 0.0122 0.3545
Plasmodium falciparum hexose transporter 0.0052 0.0122 0.5601
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0036 0.0075 0.0584
Schistosoma mansoni hypothetical protein 0.0032 0.0063 0.0217
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.003 0.0085
Loa Loa (eye worm) hypothetical protein 0.0121 0.0327 0.0964
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Schistosoma mansoni hypothetical protein 0.0081 0.0208 0.0813
Brugia malayi nuclear receptor NHR-88 0.0045 0.0102 0.0273
Echinococcus granulosus mitogen activated protein kinase 11 0.0126 0.0343 0.113
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0121 0.3444
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0076 0.031
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.003 0.002
Brugia malayi nuclear receptor NHR-88 0.0021 0.0031 0.0063
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0024 0.0597
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0024 0.0597
Loa Loa (eye worm) hypothetical protein 0.0045 0.0102 0.03
Loa Loa (eye worm) calpain 0.0019 0.0024 0.0071
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.0102 0.0378
Loa Loa (eye worm) major facilitator superfamily transporter 0.0052 0.0122 0.0358
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.0102 0.03
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0015 0.005
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0033 0.0096
Loa Loa (eye worm) nuclear receptor NHR-67 0.0021 0.0031 0.0091
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0077 0.0315
Schistosoma mansoni hypothetical protein 0.0069 0.0173 0.0669
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0023 0.0168
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0085 0.2386
Brugia malayi Death domain containing protein 0.0014 0.001 0.0001
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.0102 0.03
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0009 0.0256
Loa Loa (eye worm) hypothetical protein 0.0081 0.0208 0.0613
Trypanosoma brucei glucose transporter, putative 0.0052 0.0122 0.3465
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.0666
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.0102 0.0336
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0052 0.0122 0.0401
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0091
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0184
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.003 0.0182
Echinococcus granulosus histone acetyltransferase KAT2B 0.028 0.0802 0.2644
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.003 0.002
Loa Loa (eye worm) RNA binding protein 0.0124 0.0337 0.0994
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0071 0.3103
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0077 0.02
Onchocerca volvulus 0.0052 0.0122 0.1388
Loa Loa (eye worm) nuclear hormone receptor 0.0021 0.0031 0.0091
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.003 0.1217
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.025 0.0711
Loa Loa (eye worm) calpain 5 0.0019 0.0024 0.0071
Echinococcus granulosus calpain A 0.0019 0.0024 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Leishmania major cytochrome p450-like protein 0.0036 0.0075 0.2086
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0358
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0075 0.022
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0149 0.4275
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0102 0.0273
Onchocerca volvulus 0.0052 0.0122 0.1388
Schistosoma mansoni inositol monophosphatase 0.0036 0.0076 0.0271
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0088 0.0231
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0074 0.0579
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0149 0.0139
Schistosoma mansoni sugar transporter 0.0052 0.0122 0.0458
Echinococcus granulosus solute carrier family 22 0.0052 0.0122 0.0401
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0071 0.2453
Loa Loa (eye worm) hypothetical protein 0.0081 0.0209 0.0617
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.0102 0.03
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0039 0.0086
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0268 0.0765
Echinococcus multilocularis jun protein 0.0083 0.0216 0.0883
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0358
Echinococcus granulosus expressed protein 0.004 0.0088 0.029
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.003 0.0182
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0074 0.0191
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0076 0.0856
Leishmania major cytochrome p450-like protein 0.0036 0.0075 0.2086
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.003 0.0182
Trypanosoma brucei antigen, putative 0.0019 0.0024 0.0597
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0121 0.3525
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0015 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.0216 0.0883
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0227
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.025 0.0825
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0023 0.0039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0119 0.0108
Loa Loa (eye worm) calpain family protein 1 0.0064 0.0158 0.0467
Brugia malayi follicle stimulating hormone receptor 0.0235 0.0667 0.1947
Brugia malayi MH1 domain containing protein 0.0016 0.0015 0.0016
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0075 0.2184
Trypanosoma brucei glucose transporter, putative 0.0052 0.0122 0.3465
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0182 0.1553
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0091
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.003 0.0061
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0056 0.0185
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.0833 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0015 0.0044
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0005 0.0017
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0036 0.0075 0.0584
Loa Loa (eye worm) hypothetical protein 0.0072 0.0182 0.0535
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0036 0.0075 0.2086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.0102 0.03
Leishmania major glucose transporter, lmgt1 0.0052 0.0122 0.3465
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0075 0.2086
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0182 0.0509
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0121 0.3525
Leishmania major ABC-thiol transporter 0.0014 0.001 0.0163
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0085 0.022 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0056 0.2402
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.003 0.002
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0033 0.0066 0.1826
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0111 0.0326
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.003 0.0182
Brugia malayi Sugar transporter family protein 0.0052 0.0122 0.0331
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0107 0.0287 0.0846
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0149 0.0608
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0024 0.0713
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0091
Treponema pallidum recombinase A 0.0107 0.0287 0.2427
Trypanosoma cruzi kinesin, putative 0.0019 0.0024 0.0713
Loa Loa (eye worm) hypothetical protein 0.0026 0.0046 0.0135
Echinococcus granulosus cytochrome P450 2K1 0.0036 0.0075 0.0247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0111 0.0414
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0024 0.0713
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0119 0.0108
Echinococcus multilocularis synaptic vesicle 2 protein 0.0052 0.0122 0.0498
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0052 0.0122 0.3465
Schistosoma mansoni nuclear receptor 0.0021 0.0031 0.0087
Schistosoma mansoni hypothetical protein 0.0032 0.0063 0.0217
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0036 0.0075 0.0584
Onchocerca volvulus 0.0052 0.0122 0.1388
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0091
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.003 0.0076
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0121 0.0356
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0036 0.0075 0.0584
Echinococcus multilocularis Smad4 0.0016 0.0015 0.0062
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0071 0.0209
Leishmania major glucose transporter, lmgt3 0.0052 0.0122 0.3465
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0036 0.0075 0.0064
Schistosoma mansoni glucose transport protein 0.0052 0.0122 0.0458
Brugia malayi MH2 domain containing protein 0.0016 0.0015 0.0016
Brugia malayi hypothetical protein 0.0052 0.0122 0.0331
Brugia malayi Protein kinase domain containing protein 0.0016 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0054 0.0127 0.0375
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0111 0.0452
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0076 0.0648
Brugia malayi Inositol-1 0.0036 0.0076 0.0196
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0036 0.0075 0.0064
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0173 0.0484
Brugia malayi Major Facilitator Superfamily protein 0.0052 0.0122 0.0331
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.025 0.2959
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0121 0.3525
Giardia lamblia Sugar-proton symporter 0.0052 0.0122 0.1361
Brugia malayi calpain family protein 1 0.0064 0.0158 0.044
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.0102 0.0378
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0048 0.0139
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.003 0.0182
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0182 0.0509
Brugia malayi hypothetical protein 0.0024 0.0039 0.0086
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0182 0.2087
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0111 0.0366
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.0833 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0112 0.0418
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0036 0.0075 0.0064
Loa Loa (eye worm) hypothetical protein 0.0045 0.0102 0.03
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0052 0.0122 0.5601
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.0102 0.0416
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0121 0.3444
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0021 0.0031 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.1253
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0182 0.0171
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0149 0.0491
Onchocerca volvulus 0.0052 0.0122 0.1388
Brugia malayi steroid hormone receptor 0.0045 0.0102 0.0273
Brugia malayi calpain family protein 1 0.0064 0.0158 0.044
Loa Loa (eye worm) Smad1 0.0016 0.0015 0.0044
Echinococcus granulosus solute carrier family 22 0.0052 0.0122 0.0401
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0111 0.0452
Leishmania major protein kinase, putative 0.0014 0.0009 0.0134
Trypanosoma brucei glucose transporter, putative 0.0052 0.0122 0.3465
Schistosoma mansoni smad1 5 8 and 0.0016 0.0015 0.0022
Schistosoma mansoni Smad4 0.0016 0.0015 0.0022
Trypanosoma cruzi hexose transporter, putative 0.0052 0.0122 0.3545
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0056 0.019
Leishmania major p-glycoprotein e 0.0014 0.001 0.0163
Loa Loa (eye worm) DR-78 0.0021 0.0031 0.0091
Onchocerca volvulus 0.0036 0.0074 0.0824
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.003 0.002
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0102 0.0378
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0089
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.003 0.0101
Loa Loa (eye worm) sugar transporter 0.0052 0.0122 0.0358
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.0102 0.0378
Loa Loa (eye worm) cytochrome P450 family protein 0.0211 0.0596 0.1759
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0024 0.0597
Echinococcus multilocularis solute carrier family 22 0.0052 0.0122 0.0496
Echinococcus multilocularis 0.0036 0.0075 0.0306
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0014 0.001 0.0285
Trypanosoma brucei glucose transporter 1E 0.0052 0.0122 0.3465
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0337 0.1341
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.0102 0.0273
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0031 0.0102
Schistosoma mansoni glucose transport protein 0.0052 0.0122 0.0458
Echinococcus granulosus lamin 0.0027 0.0048 0.0157
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0121 0.0493
Mycobacterium ulcerans recombinase A 0.0107 0.0287 0.2512
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.0833 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0036 0.0075 0.0064
Toxoplasma gondii transporter, major facilitator family protein 0.0052 0.0122 0.5435
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.025 0.2959
Leishmania major pentamidine resistance protein 1 0.0014 0.001 0.0163
Trichomonas vaginalis bromodomain-containing protein, putative 0.0085 0.022 0.2596
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0031 0.0127
Echinococcus granulosus solute carrier family 22 0.0052 0.0122 0.0401
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.0102 0.0273
Giardia lamblia MRP-like ABC transporter 0.0014 0.001 0.0004
Brugia malayi conserved hypotetical protein 0.0021 0.0031 0.0063
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0071 0.2077
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.025 0.0737
Brugia malayi MAP kinase sur-1 0.0051 0.0121 0.0329
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.0833 1
Brugia malayi Cytochrome P450 family protein 0.0211 0.0596 0.1736
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0063 0.0157
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0126 0.0343 1
Plasmodium vivax SET domain protein, putative 0.003 0.0056 0.1686
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0021 0.0031 0.0102
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0102 0.0273
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0075 0.2184
Entamoeba histolytica acetyltransferase, GNAT family 0.0078 0.0199 0.2299
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0091
Echinococcus multilocularis multidrug resistance associated protein 1 0.0014 0.001 0.004
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0014 0.001 0.0028
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0052 0.0122 0.0401
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0139
Echinococcus granulosus mitogen activated protein kinase 14 0.0126 0.0343 0.113
Leishmania major basic transcription factor 3a, putative 0.0035 0.0071 0.1978
Onchocerca volvulus 0.0052 0.0122 0.1388
Echinococcus granulosus Sugar transporter ERD6 protein 0.0052 0.0122 0.0401
Schistosoma mansoni calpain (C02 family) 0.0019 0.0024 0.006
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0052 0.0122 0.0111
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0036 0.0075 0.0584
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0024 0.0597
Echinococcus granulosus transcription factor btf3 0.0035 0.0071 0.0235
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0102 0.0336
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0023 0.0066
Trypanosoma cruzi multidrug resistance protein E, putative 0.0014 0.001 0.0285
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0121 0.1398
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.001 0.0029
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0358
Loa Loa (eye worm) hypothetical protein 0.0072 0.0182 0.0535
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0031 0.0063
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0584 0.1723
Schistosoma mansoni netrin receptor unc5 0.0014 0.001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0122 0.1406
Loa Loa (eye worm) hypothetical protein 0.0045 0.0102 0.03
Onchocerca volvulus 0.0236 0.0669 0.7917
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0015 0.0062
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0077 0.2251
Echinococcus multilocularis inhibitor of apoptosis protein 0.0081 0.0208 0.0849
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0081 0.0208 0.0587
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0036 0.0075 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.0102 0.03
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0126 0.0343 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.0102 0.0336
Trypanosoma cruzi kinesin, putative 0.0019 0.0024 0.0713
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0024 0.0713
Trypanosoma brucei p-glycoprotein 0.0014 0.001 0.0163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.0833 1
Brugia malayi nuclear receptor RXR 0.0021 0.0031 0.0063
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.003 0.0182
Schistosoma mansoni lamin 0.0027 0.0048 0.0155
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0091
Leishmania major glucose transporter, lmgt2 0.0052 0.0122 0.3465
Trichomonas vaginalis glucose transporter, putative 0.0052 0.0122 0.1406
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0182 0.2087
Echinococcus granulosus FTZ F1 alpha 0.0045 0.0102 0.0336
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0021 0.0031 0.0127
Plasmodium vivax sugar transporter, putative 0.0052 0.0122 0.5004
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0031 0.0102
Brugia malayi RNA binding protein 0.0124 0.0337 0.0969
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0075 0.022
Echinococcus granulosus lamin dm0 0.0027 0.0048 0.0157
Echinococcus granulosus multidrug resistance associated protein 7 0.0014 0.001 0.0032
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0075 0.2184
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0036 0.0075 0.2086
Echinococcus granulosus intermediate filament protein 0.0027 0.0048 0.0157
Brugia malayi AMP-binding enzyme family protein 0.0021 0.003 0.0061
Onchocerca volvulus 0.0052 0.0122 0.1388
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0288 0.0826 0.3344
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0017
Brugia malayi hypothetical protein 0.0021 0.0031 0.0063
Brugia malayi beta-NAC-like protein 0.0035 0.0071 0.0182
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0122 0.1406
Echinococcus granulosus calpain A 0.0067 0.0168 0.0554
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0182 0.0529
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.003 0.0182
Onchocerca volvulus Putative transporter 0.0052 0.0122 0.1388
Echinococcus granulosus solute carrier family 22 0.0052 0.0122 0.0401
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0127 0.594
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.0102 0.0416
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.003 0.0182
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0036 0.0075 0.0584
Onchocerca volvulus 0.0081 0.0208 0.2419
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.003 0.0389
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0074 0.0303
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0089
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0085 0.2386
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0127 0.1106
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0036 0.0075 0.0584
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.025 0.1021
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0009 0.0256
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0384 0.1112 1
Echinococcus granulosus death domain containing protein 0.0014 0.001 0.0034
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0009 0.0256
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0036 0.0075 0.0064
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0024 0.0178
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0122 0.1406
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0063 0.0256
Schistosoma mansoni smad1 5 8 and 0.0016 0.0015 0.0022
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0182 0.2087
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0036 0.0075 0.0584
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.036
Toxoplasma gondii propionate-CoA ligase 0.0021 0.003 0.1217
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0039 0.0158
Onchocerca volvulus 0.0045 0.0102 0.1155
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0024 0.0713
Onchocerca volvulus Netrin receptor homolog 0.0014 0.001 0.0061
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0075 0.2184
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0014 0.001 0.0285
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0088 0.0258
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0109 0.1253
Brugia malayi cytochrome P450 0.0036 0.0075 0.0193
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.003 0.0076
Echinococcus granulosus multidrug resistance associated protein 1 0.0014 0.001 0.0032
Brugia malayi Sugar transporter family protein 0.0052 0.0122 0.0331
Brugia malayi major facilitator superfamily protein 0.0052 0.0122 0.0331
Trypanosoma brucei glucose transporter, putative 0.0052 0.0122 0.3465
Echinococcus multilocularis lamin 0.0027 0.0048 0.0194
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0358
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.003 0.0776
Loa Loa (eye worm) hypothetical protein 0.0045 0.0102 0.0299
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.0216 0.0713
Trypanosoma brucei THT1 - hexose transporter, putative 0.0052 0.0122 0.3465
Onchocerca volvulus 0.0052 0.0122 0.1388
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0036 0.0075 0.0584
Echinococcus multilocularis conserved hypothetical protein 0.0686 0.201 0.8207
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0113
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0121 0.1398
Leishmania major kinesin, putative 0.0019 0.0024 0.0597
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0077 0.087

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0891 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 0.1853 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.3459 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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