Detailed information for compound 1269956

Basic information

Technical information
  • TDR Targets ID: 1269956
  • Name: (E)-3-(4-bromophenyl)-2-(5-piperidin-1-ylsulf onylthiophen-2-yl)prop-2-enoic acid
  • MW: 456.374 | Formula: C18H18BrNO4S2
  • H donors: 1 H acceptors: 4 LogP: 4.24 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)/C(=C\c1ccc(cc1)Br)/c1ccc(s1)S(=O)(=O)N1CCCCC1
  • InChi: 1S/C18H18BrNO4S2/c19-14-6-4-13(5-7-14)12-15(18(21)22)16-8-9-17(25-16)26(23,24)20-10-2-1-3-11-20/h4-9,12H,1-3,10-11H2,(H,21,22)/b15-12-
  • InChiKey: PJDVEXPLLHAFQN-QINSGFPZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-bromophenyl)-2-(5-piperidin-1-ylsulfonylthiophen-2-yl)prop-2-enoic acid
  • (E)-3-(4-bromophenyl)-2-[5-(1-piperidylsulfonyl)-2-thienyl]prop-2-enoic acid
  • 3-(4-bromophenyl)-2-[5-(1-piperidylsulfonyl)-2-thienyl]prop-2-enoic acid
  • (E)-3-(4-bromophenyl)-2-(5-piperidinosulfonyl-2-thienyl)acrylic acid
  • 3-(4-bromophenyl)-2-(5-piperidinosulfonyl-2-thienyl)acrylic acid
  • T0519-5044
  • MLS000339654
  • SMR000242071

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0441 0.2615
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0016
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0042 0.0197
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0121 0.141
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0042 0.0236
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0166 0.0547
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0074 0.0168 0.0554
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0077 0.0384
Loa Loa (eye worm) DR-78 0.0013 0.0003 0.0016
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0107 0.6354
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0038 0.0307
Trypanosoma brucei kinesin, putative 0.0021 0.0024 0.0607
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0016
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0077 0.0819
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0047 0.0096 0.2715
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0042 0.0211
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0042 0.0197
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0017 0.0013
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0232 0.0229
Onchocerca volvulus 0.0047 0.0096 0.1394
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0166 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0056 0.0332
Onchocerca volvulus 0.0047 0.0096 0.1394
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0047 0.0096 0.0316
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0067 0.0063
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0166 0.0825
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0024 0.0607
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0023 0.0029 0.023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0042 0.0197
Schistosoma mansoni glucose transport protein 0.0047 0.0096 0.0463
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0042 0.014
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0053 0.0174
Mycobacterium tuberculosis Conserved protein 0.0037 0.0067 0.0063
Leishmania major glucose transporter/membrane transporter D2, putative 0.0047 0.0096 0.2715
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0023 0.0029 0.023
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0047 0.0096 0.083
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0029 0.0857
Onchocerca volvulus 0.005 0.0102 0.1481
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0056
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0007 0.0024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0029
Giardia lamblia Hexose transporter 0.0047 0.0096 0.111
Echinococcus granulosus jun protein 0.0092 0.0216 0.0713
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0005 0.0015
Leishmania major kinesin, putative 0.0021 0.0024 0.0607
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0198 0.0502 0.7491
Brugia malayi Death domain containing protein 0.0016 0.001 0.0043
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0023 0.0029 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0042 0.0251
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.025 0.0825
Trypanosoma cruzi hexose transporter, putative 0.0047 0.0096 0.2797
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0067 0.057
Schistosoma mansoni sugar transporter 0.0047 0.0096 0.0463
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0041
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0023 0.0029 0.023
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.057
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0166 0.0162
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0003 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0056 0.0264
Echinococcus granulosus lamin 0.003 0.0048 0.0157
Giardia lamblia MRP-like ABC transporter 0.0016 0.001 0.0071
Brugia malayi nuclear receptor NHR-88 0.0028 0.0042 0.0236
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0121 0.3525
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0016
Echinococcus granulosus calpain A 0.0021 0.0024 0.0081
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0072 0.6627
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0042 0.0197
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0118
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.001 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0004 0.0113
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0003 0.0015
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0005 0.0026
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0067 0.0762
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0047 0.0096 0.0092
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0067 0.0063
Onchocerca volvulus 0.0037 0.0067 0.0962
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.0398
Echinococcus granulosus mitogen activated protein kinase 11 0.0139 0.0343 0.113
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0942
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0047 0.0096 0.0316
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0023 0.0029 0.0025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0038 0.0342
Trypanosoma brucei glucose transporter 2A 0.0047 0.0096 0.2715
Onchocerca volvulus 0.0047 0.0096 0.1394
Trypanosoma cruzi hexose transporter, putative 0.0047 0.0096 0.2797
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.002 0.0147
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.025 0.2969
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.032 0.0833 1
Trichomonas vaginalis esterase, putative 0.0037 0.0067 0.0762
Trypanosoma brucei protein kinase, putative 0.0057 0.0121 0.3451
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0016 0.001 0.0173
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Echinococcus granulosus transcription factor btf3 0.0038 0.0071 0.0235
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0105 0.0611
Schistosoma mansoni kinase 0.0054 0.0113 0.0546
Trypanosoma brucei polo-like protein kinase 0.0104 0.025 0.7264
Echinococcus granulosus synaptic vesicle 2 protein 0.0048 0.0096 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.0398
Plasmodium vivax SET domain protein, putative 0.0033 0.0056 0.5068
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0042 0.0236
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0011 0.0037
Echinococcus granulosus multidrug resistance associated protein 7 0.0016 0.001 0.0032
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0023 0.0029 0.023
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0077 0.037
Brugia malayi Cytochrome P450 family protein 0.0023 0.0029 0.0158
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0077 0.037
Leishmania major cytochrome p450-like protein 0.0023 0.0029 0.0752
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0109 0.1266
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0107 0.0352
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0042 0.014
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0023 0.0029 0.023
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0005 0.015
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.057
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0067 0.0383
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.0036
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0056 0.322
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0833 1
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0074 0.0366
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0139 0.0343 1
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.001 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0056 0.0264
Mycobacterium ulcerans hypothetical protein 0.0026 0.0038 0.0307
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0023 0.0029 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0023 0.0029 0.0025
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0005 0.0015
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0107 0.1242
Echinococcus multilocularis synaptic vesicle 2 protein 0.0048 0.0096 0.048
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0251
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.025 0.7295
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0042 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0015
Onchocerca volvulus 0.0039 0.0074 0.107
Onchocerca volvulus Netrin receptor homolog 0.0016 0.001 0.0109
Brugia malayi cytochrome P450 0.0023 0.0029 0.0158
Schistosoma mansoni microtubule-associated protein tau 0.0756 0.201 1
Brugia malayi Sugar transporter family protein 0.0047 0.0096 0.0555
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0042 0.0593
Loa Loa (eye worm) sugar transporter 0.0047 0.0096 0.057
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0121 0.3525
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0095 0.1102
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0038 0.0098
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0038 0.1003
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0024 0.0107
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0042 0.0236
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.001 0.0059
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Mycobacterium leprae Conserved hypothetical protein 0.0023 0.0029 0.0073
Onchocerca volvulus Huntingtin homolog 0.0148 0.0368 0.5473
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0156 0.039 0.3489
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0107 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0206 0.0202
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0224
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0024 0.0081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0004 0.0113
Echinococcus granulosus calpain 5 0.0021 0.0024 0.0081
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.0232 0.0229
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0016 0.001 0.0285
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Trypanosoma cruzi DNA repair protein, putative 0.0036 0.0066 0.1927
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0006 0.0031
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0038 0.0307
Brugia malayi hypothetical protein 0.0072 0.0163 0.0955
Leishmania major basic transcription factor 3a, putative 0.0038 0.0071 0.1986
Schistosoma mansoni lamin 0.003 0.0048 0.0222
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0166 0.1463
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0023 0.0029 0.0025
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0036 0.0066 0.1834
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0023 0.0029 0.0025
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0029 0.0173
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0042 0.0211
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0024 0.0713
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0121 0.141
Loa Loa (eye worm) hypothetical protein 0.0148 0.0368 0.219
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.001 0.006
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0067 0.0762
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0056 0.0264
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0251
Brugia malayi beta-lactamase family protein 0.0037 0.0067 0.0383
Schistosoma mansoni hypothetical protein 0.0016 0.0011 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0042 0.0211
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0071 0.0746
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.025 0.2969
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0251
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0005 0.0015
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0038 0.0342
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0074 0.0242
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.025 0.2919
Schistosoma mansoni glucose transport protein 0.0047 0.0096 0.0463
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Echinococcus granulosus multidrug resistance associated protein 1 0.0016 0.001 0.0032
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.057
Trichomonas vaginalis glucose transporter, putative 0.0047 0.0096 0.111
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Trypanosoma brucei THT1 - hexose transporter, putative 0.0047 0.0096 0.2715
Brugia malayi Pre-SET motif family protein 0.0228 0.0584 0.3468
Loa Loa (eye worm) acetyltransferase 0.0175 0.0441 0.2627
Loa Loa (eye worm) hypothetical protein 0.0148 0.0368 0.219
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0054
Onchocerca volvulus 0.0026 0.0038 0.0524
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0118
Trypanosoma brucei glucose transporter, putative 0.0047 0.0096 0.2715
Echinococcus granulosus Solute carrier family 22 5 0.1134 0.3032 1
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Brugia malayi follicle stimulating hormone receptor 0.0259 0.0667 0.3968
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0038 0.0034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0056 0.0279
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0118
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0062 0.0351
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0067 0.0149 0.0872
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0024 0.0607
Treponema pallidum replicative DNA helicase (dnaB) 0.0423 0.1112 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0059
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0047 0.0096 0.083
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0071 0.0422
Echinococcus multilocularis mitogen activated protein kinase 14 0.0139 0.0343 0.1705
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.025 0.2969
Plasmodium vivax sugar transporter, putative 0.0047 0.0096 0.8934
Loa Loa (eye worm) cytochrome P450 0.0023 0.0029 0.0173
Brugia malayi beta-lactamase 0.0037 0.0067 0.0383
Schistosoma mansoni hydrolase 0.0041 0.008 0.0382
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.0398
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0016 0.001 0.0007
Brugia malayi beta-lactamase family protein 0.0037 0.0067 0.0383
Plasmodium falciparum thioredoxin reductase 0.0039 0.0072 0.7417
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0067 0.6138
Brugia malayi major facilitator superfamily protein 0.0047 0.0096 0.0555
Brugia malayi Thioredoxin reductase 0.0039 0.0072 0.0413
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0042 0.0593
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0035
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.001 0.0051
Brugia malayi beta-NAC-like protein 0.0038 0.0071 0.0407
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0166 0.1463
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0047 0.0096 0.0477
Trypanosoma cruzi hexose transporter, putative 0.0047 0.0096 0.2797
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0042 0.0197
Brugia malayi small heat shock protein 0.0632 0.1678 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0024 0.0607
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0042 0.0236
Echinococcus granulosus GPCR family 2 0.0016 0.0011 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0096 0.111
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0047 0.0096 0.0477
Loa Loa (eye worm) sugar transporter 0.0047 0.0096 0.057
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0096 0.111
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0023 0.0029 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0071 0.0812
Schistosoma mansoni lamin 0.003 0.0048 0.0222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0042 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0015
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0067 0.0186
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0067 0.0149 0.4281
Trypanosoma brucei glucose transporter, putative 0.0047 0.0096 0.2715
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0029 0.0752
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0016 0.001 0.0285
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0024 0.0713
Echinococcus granulosus Sugar transporter ERD6 protein 0.0047 0.0096 0.0316
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0016
Mycobacterium leprae putative cytochrome p450 0.0023 0.0029 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0833 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0042 0.0236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0042 0.0251
Loa Loa (eye worm) intermediate filament protein 0.003 0.0048 0.0281
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0224
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0047 0.0096 0.0463
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0092 0.0216 0.1076
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Toxoplasma gondii ABC1 family protein 0.0037 0.0067 0.39
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0009 0.0256
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0038 0.0034
Brugia malayi hypothetical protein 0.0015 0.0007 0.0025
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0942
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0109 0.1266
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0121 0.3451
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.002 0.0147
Brugia malayi Major Facilitator Superfamily protein 0.0047 0.0096 0.0555
Echinococcus granulosus solute carrier family 22 0.0047 0.0096 0.0316
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0029 0.023
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0077 0.0254
Trypanosoma brucei sugar transporter, putative 0.0047 0.0096 0.2715
Brugia malayi ABC transporter transmembrane region family protein 0.0016 0.001 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0096 0.111
Schistosoma mansoni hypothetical protein 0.0205 0.0521 0.258
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0011 0.0065
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0095 0.9933
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0042 0.0251
Trypanosoma cruzi kinesin, putative 0.0021 0.0024 0.0713
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0038 0.0307
Leishmania major cytochrome p450-like protein 0.0023 0.0029 0.0752
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0024 0.0607
Treponema pallidum recombinase A 0.0118 0.0287 0.2557
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0005 0.0015
Echinococcus granulosus solute carrier family 22 0.0047 0.0096 0.0316
Echinococcus multilocularis multidrug resistance associated protein 7 0.0016 0.001 0.0049
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0121 0.3451
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0034 0.006 0.1651
Brugia malayi calpain 7 0.0021 0.0024 0.0128
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0007 0.0025
Onchocerca volvulus 0.0047 0.0096 0.1394
Schistosoma mansoni hypothetical protein 0.0047 0.0096 0.0463
Treponema pallidum fructose-bisphosphate aldolase 0.032 0.0833 0.7484
Echinococcus granulosus netrin receptor unc 5 0.0016 0.001 0.0034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0017 0.0013
Echinococcus granulosus mitogen activated protein kinase 14 0.0139 0.0343 0.113
Mycobacterium ulcerans beta-lactamase 0.0037 0.0067 0.057
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0013
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0005 0.0011
Onchocerca volvulus 0.0072 0.0163 0.24
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0042 0.0251
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0067 0.1957
Leishmania major hypothetical protein, conserved 0.0037 0.0067 0.1865
Loa Loa (eye worm) hypothetical protein 0.0179 0.0451 0.2686
Leishmania major glucose transporter, lmgt1 0.0047 0.0096 0.2715
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0251
Brugia malayi calpain family protein 1 0.0071 0.0158 0.0928
Echinococcus multilocularis multidrug resistance associated protein 1 0.0016 0.001 0.0049
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0067 0.0149 0.0727
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0156 0.039 0.1155
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.0398
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0005 0.0037
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0023 0.0029 0.023
Loa Loa (eye worm) hypothetical protein 0.004 0.0077 0.0458
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0023 0.0029 0.023
Brugia malayi P38 map kinase family protein 2 0.0139 0.0343 0.2029
Leishmania major glucose transporter, lmgt2 0.0047 0.0096 0.2715
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0016
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0029 0.0173
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0003 0.0015
Trypanosoma brucei glucose transporter, putative 0.0047 0.0096 0.2715
Echinococcus multilocularis calpain 5 0.0021 0.0024 0.0122
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0042 0.0197
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.0149 0.131
Schistosoma mansoni multidrug resistance protein 0.0016 0.001 0.0034
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.001 0.0045
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0067 0.0398
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0023 0.0029 0.0025
Chlamydia trachomatis recombinase RecA 0.0118 0.0287 0.2557
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0023 0.0029 0.0025
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Onchocerca volvulus 0.0037 0.0067 0.0962
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0023 0.0029 0.023
Giardia lamblia ABC transporter, putative 0.0016 0.001 0.0071
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0074 0.0168 0.0823
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0077 0.2163
Loa Loa (eye worm) hypoxia-induced factor 1 0.0165 0.0413 0.2463
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.0603 0.0599
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0074 0.0168 0.0836
Schistosoma mansoni hypothetical protein 0.0016 0.0011 0.0041
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.0232 0.0682
Brugia malayi ecdysteroid receptor 0.0028 0.0042 0.0236
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.0584 0.3479
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0206 0.0202
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0024 0.0713
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0077 0.0884
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0077 0.2251
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.025 0.7264
Leishmania major hypothetical protein, conserved 0.0047 0.0096 0.2715
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0067 0.1865
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0007 0.0021
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.057
Plasmodium falciparum hexose transporter 0.0047 0.0096 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.057
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0005 0.0029
Trypanosoma brucei glucose transporter, putative 0.0047 0.0096 0.2715
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0042 0.0236
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.057
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0067 0.0762
Brugia malayi hypoxia-induced factor 1 0.0165 0.0413 0.2451
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0056 0.0279
Leishmania major protein kinase, putative 0.0019 0.002 0.0484
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0011 0.0056
Leishmania major protein kinase, putative 0.0015 0.0009 0.0144
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0041
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0023 0.0029 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0042 0.0236
Brugia malayi hypothetical protein 0.0047 0.0096 0.0555
Trypanosoma brucei glucose transporter, putative 0.0047 0.0096 0.2715
Leishmania major trypanothione reductase 0.0039 0.0072 0.2013
Mycobacterium ulcerans integral membrane transport protein 0.0047 0.0096 0.083
Loa Loa (eye worm) hypothetical protein 0.0048 0.0096 0.0573
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0121 0.141
Onchocerca volvulus 0.0047 0.0096 0.1394
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0071 0.0812
Brugia malayi Protein kinase domain containing protein 0.0017 0.0014 0.0065
Mycobacterium leprae Probable lipase LipE 0.0037 0.0067 0.0186
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0107 0.1242
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0071 0.0812
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0042 0.014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0067 0.0319
Onchocerca volvulus 0.0047 0.0096 0.1394
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0077 0.0884
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0067 0.0221
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0072 0.0428
Onchocerca volvulus 0.026 0.0669 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0003 0.0015
Plasmodium vivax calpain, putative 0.0021 0.0024 0.1997
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0067 0.0762
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.002 0.1767
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0121 0.0398
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0121 0.0601
Entamoeba histolytica calpain large subunit domain III containing protein 0.0021 0.0024 0.0178
Loa Loa (eye worm) hypothetical protein 0.005 0.0102 0.0604
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0042 0.014
Brugia malayi hypothetical protein 0.0047 0.0096 0.0555
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0042 0.0197
Brugia malayi major facilitator superfamily protein 0.0047 0.0096 0.0555
Brugia malayi PAS domain containing protein 0.0053 0.0112 0.0649
Onchocerca volvulus 0.0028 0.0042 0.0593
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0186 0.0924
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0096 0.111
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0074 0.0635
Trypanosoma cruzi hexose transporter, putative 0.0047 0.0096 0.2797
Trypanosoma brucei trypanothione reductase 0.0039 0.0072 0.2013
Trichomonas vaginalis glucose transporter, putative 0.0047 0.0096 0.111
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0047 0.0096 0.0316
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0042 0.0197
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0023 0.0029 0.023
Brugia malayi Uncoordinated protein 44 0.0016 0.001 0.0043
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0077 0.0254
Onchocerca volvulus 0.0016 0.0011 0.0123
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0029 0.0857
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0077 0.0384
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0077 0.0884
Loa Loa (eye worm) major facilitator superfamily transporter 0.0047 0.0096 0.057
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0024 0.0713
Brugia malayi Cytochrome P450 family protein 0.0023 0.0029 0.0158
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0029 0.0173
Trypanosoma brucei THT1 - hexose transporter, putative 0.0047 0.0096 0.2715
Onchocerca volvulus 0.0014 0.0005 0.0032
Trypanosoma brucei antigen, putative 0.0021 0.0024 0.0607
Schistosoma mansoni calpain-7 (C02 family) 0.0024 0.0033 0.0151
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0003 0.0015
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0074 0.0369
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.025 0.2969
Loa Loa (eye worm) calpain family protein 1 0.005 0.0102 0.0604
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.025 0.2969
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0004 0.0113
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0009 0.0256
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0072 0.2104
Echinococcus multilocularis calpain A 0.0074 0.0168 0.0836
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0023 0.0029 0.0025
Giardia lamblia Multidrug resistance-associated protein 1 0.0016 0.001 0.0071
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0023 0.0029 0.023
Echinococcus multilocularis transcription factor btf3 0.0038 0.0071 0.0354
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.057
Echinococcus granulosus calpain 0.0021 0.0024 0.0081
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0038 0.0307
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0121 0.0718
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0042 0.014
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0251
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0126 0.075
Schistosoma mansoni transcription factor btf3 0.0038 0.0071 0.034
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.001 0.0043
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0016 0.001 0.0363
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0302 0.0783 0.3896
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0023 0.0029 0.0025
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0077 0.0384
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.002 0.0016
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3406 0.9175 0.9175
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0251
Loa Loa (eye worm) twinkle helicase 0.0121 0.0295 0.1754
Mycobacterium tuberculosis Conserved protein 0.0037 0.0067 0.0063
Leishmania major ABC-thiol transporter 0.0016 0.001 0.0173
Echinococcus granulosus single minded 2 0.0039 0.0074 0.0245
Leishmania major cytochrome p450-like protein 0.0023 0.0029 0.0752
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0107 0.6354
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0016
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0441 0.2181
Trypanosoma brucei glucose transporter, putative 0.0047 0.0096 0.2715
Giardia lamblia Multidrug resistance-associated protein 1 0.0015 0.0009 0.0067
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0042 0.0211
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0038 0.0307
Onchocerca volvulus 0.0047 0.0096 0.1394
Trypanosoma brucei glucose transporter 1E 0.0047 0.0096 0.2715
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0004 0.0113
Schistosoma mansoni multidrug resistance protein 0.0016 0.001 0.0034
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0206 0.0602
Schistosoma mansoni coup transcription factor 0.0028 0.0042 0.0197
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0833 1
Onchocerca volvulus 0.0037 0.0067 0.0962
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0067 0.0149 0.0145
Echinococcus granulosus abhydrolase domain containing protein 0.0041 0.008 0.0263
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0024 0.0122
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Toxoplasma gondii facilitative glucose transporter GT1 0.0047 0.0096 0.5677
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0011 0.0038
Brugia malayi Sugar transporter family protein 0.0047 0.0096 0.0555
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.0398
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0011 0.0049
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0166 0.0812
Toxoplasma gondii cytochrome p450 superfamily protein 0.0023 0.0029 0.1572
Schistosoma mansoni sugar transporter 0.0047 0.0096 0.0463
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0042 0.0236
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0024 0.0107
Onchocerca volvulus 0.0047 0.0096 0.1394
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0095 0.1039
Trypanosoma cruzi DNA repair protein, putative 0.0036 0.0066 0.1927
Echinococcus multilocularis calpain family protein 1, d 0.005 0.0102 0.0506
Echinococcus granulosus microtubule associated protein 2 0.0756 0.201 0.663
Echinococcus multilocularis Ankyrin 0.0016 0.0011 0.0053
Schistosoma mansoni multidrug resistance protein 0.0016 0.001 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0024 0.0713
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0042 0.0236
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0023 0.0029 0.023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0833 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0023 0.0029 0.023
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0065
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0056 0.0264
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0121 0.3525
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0026
Onchocerca volvulus 0.0047 0.0096 0.1394
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0096 0.111
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0003 0.0016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0067 0.0319
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0206 0.0202
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0003 0.0016
Schistosoma mansoni single-minded 0.0053 0.0112 0.0542
Echinococcus multilocularis lamin 0.003 0.0048 0.0236
Schistosoma mansoni hypothetical protein 0.0205 0.0521 0.258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0061
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0139 0.0343 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.0149 0.0491
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0016 0.001 0.0173
Echinococcus multilocularis mitogen activated protein kinase 11 0.0139 0.0343 0.1705
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0023 0.0029 0.0025
Echinococcus multilocularis solute carrier family 22 0.0047 0.0096 0.0477
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0016 0.001 0.0173
Onchocerca volvulus 0.0047 0.0096 0.1394
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0067 0.0334
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0026
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0023 0.0029 0.023
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.025 0.2969
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.025 0.1244
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0833 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0632 0.1678 1
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0118 0.0287 0.2557
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0015
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0042 0.0197
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0121 0.0398
Echinococcus granulosus calpain A 0.0074 0.0168 0.0554
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0023 0.0029 0.0025
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0042 0.0251
Echinococcus multilocularis geminin 0.0205 0.0521 0.2591
Echinococcus granulosus solute carrier family 22 0.0047 0.0096 0.0316
Plasmodium vivax hexose transporter 0.0047 0.0096 0.8934
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.057
Trypanosoma brucei multidrug resistance protein E 0.0016 0.001 0.0173
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0366
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0105 0.0626
Onchocerca volvulus 0.0047 0.0096 0.1394
Echinococcus granulosus geminin 0.0205 0.0521 0.1718
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0092 0.0216 0.0713
Plasmodium falciparum epoxide hydrolase 1 0.0041 0.008 0.8248
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0166 0.1463
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0047 0.0096 0.0477
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0047 0.0096 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0016
Onchocerca volvulus 0.0047 0.0096 0.1394
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0441 0.2193
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0023 0.0029 0.0752
Brugia malayi Major Facilitator Superfamily protein 0.0047 0.0096 0.0555
Mycobacterium leprae Conserved hypothetical protein 0.1248 0.3341 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0038 0.0307
Echinococcus multilocularis mitogen activated protein kinase 11 0.0139 0.0343 0.1705
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0067 0.0063
Brugia malayi glutathione reductase 0.0039 0.0072 0.0413
Loa Loa (eye worm) glutathione reductase 0.0039 0.0072 0.0428
Schistosoma mansoni hypothetical protein 0.0023 0.0029 0.0131
Schistosoma mansoni cytochrome P450 0.0023 0.0029 0.0131
Brugia malayi multidrug resistance related protein 1 0.0016 0.001 0.004
Leishmania major p-glycoprotein e 0.0016 0.001 0.0173
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0112 0.0542
Schistosoma mansoni glucose transport protein 0.0047 0.0096 0.0463
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Chlamydia trachomatis replicative DNA helicase 0.0423 0.1112 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0072 0.0068
Brugia malayi Cytochrome P450 family protein 0.0023 0.0029 0.0158
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0047 0.0096 0.0477
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0273
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0067 0.0063
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0016 0.001 0.0056
Giardia lamblia Fructose-bisphosphate aldolase 0.032 0.0833 1
Brugia malayi bZIP transcription factor family protein 0.0092 0.0216 0.1274
Brugia malayi hypothetical protein 0.0179 0.0451 0.2674
Onchocerca volvulus 0.0047 0.0096 0.1394
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0118
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0423 0.1112 0.3318
Echinococcus granulosus intermediate filament protein 0.003 0.0048 0.0157
Mycobacterium ulcerans hypothetical protein 0.0037 0.0067 0.057
Loa Loa (eye worm) calpain 5 0.0021 0.0024 0.0144
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0042 0.0211
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.0232 0.0229
Brugia malayi nuclear receptor RXR 0.0015 0.0007 0.0025
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0004 0.0113
Schistosoma mansoni hypothetical protein 0.0075 0.017 0.0831
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.057
Toxoplasma gondii sugar transporter ST1 0.0047 0.0096 0.5677
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0038 0.1003
Echinococcus multilocularis solute carrier family 22 0.0047 0.0096 0.0477
Trypanosoma cruzi glucose transporter, putative 0.0047 0.0096 0.2797
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0024 0.0607
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0029 0.0857
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0016
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0042 0.0593
Brugia malayi nuclear hormone receptor 0.0028 0.0042 0.0236
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0042 0.0211
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0003 0.001
Brugia malayi intermediate filament protein 0.003 0.0048 0.0266
Echinococcus multilocularis hypothetical protein 0.0021 0.0024 0.0122
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0024 0.0607
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0042 0.0211
Echinococcus multilocularis lamin dm0 0.003 0.0048 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0042 0.0236
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0005 0.0026
Schistosoma mansoni sugar transporter 0.0047 0.0096 0.0463
Schistosoma mansoni netrin receptor unc5 0.0016 0.001 0.0036
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0005 0.0015
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0042 0.0236
Trypanosoma brucei glucose transporter, putative 0.0047 0.0096 0.2715
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0042 0.014
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0003 0.0015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0011 0.0049
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0077 0.2163
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0003 0.001
Brugia malayi hydrolase, alpha/beta fold family protein 0.0041 0.008 0.0458
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Trypanosoma brucei THT1 - hexose transporter, putative 0.0047 0.0096 0.2715
Loa Loa (eye worm) calpain 0.0021 0.0024 0.0144
Leishmania major hypothetical protein, conserved 0.0041 0.008 0.2239
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0023 0.0029 0.023
Trichomonas vaginalis sugar transport protein, putative 0.0047 0.0096 0.111
Echinococcus multilocularis GPCR, family 2 0.0016 0.0011 0.0056
Mycobacterium ulcerans sugar transporter 0.0047 0.0096 0.083
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0019
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0074 0.0168 0.0823
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.001 0.0034
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.025 0.7295
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0206 0.0202
Giardia lamblia Kinase, PLK 0.0104 0.025 0.2969
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0074 0.0426
Trichomonas vaginalis set domain proteins, putative 0.0259 0.0669 0.8022
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0251
Loa Loa (eye worm) hypothetical protein 0.0198 0.0502 0.2992
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0004 0.0113
Trypanosoma cruzi hexose transporter 0.0047 0.0096 0.2797
Mycobacterium tuberculosis Conserved protein 0.0037 0.0067 0.0063
Echinococcus multilocularis solute carrier family 22 0.0047 0.0096 0.0477
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0038 0.0208
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0067 0.0063
Trichomonas vaginalis myo-inositol transporter, putative 0.0047 0.0096 0.111
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0023 0.0029 0.0025
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0077 0.0254
Schistosoma mansoni calpain-7 (C02 family) 0.0024 0.0033 0.0151
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0016
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0139 0.0343 0.2042
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0077 0.2251
Schistosoma mansoni multidrug resistance protein 0.0016 0.001 0.0034
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0042 0.0197
Echinococcus multilocularis musashi 0.003 0.0048 0.0236
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0016
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0016 0.001 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0004 0.0113
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0042 0.0197
Trypanosoma cruzi kinesin, putative 0.0021 0.0024 0.0713
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0166 0.4782
Giardia lamblia Multidrug resistance-associated protein 1 0.0016 0.001 0.0071
Echinococcus multilocularis conserved hypothetical protein 0.0756 0.201 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0042 0.0251
Mycobacterium ulcerans lipase LipD 0.0037 0.0067 0.057
Echinococcus granulosus hypothetical protein 0.0763 0.2029 0.6692
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0005 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0067 0.0063
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0259 0.0667 0.3977
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0071 0.2077
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0029 0.0857
Schistosoma mansoni hypothetical protein 0.0035 0.0062 0.0293
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0024 0.0713
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0003 0.0015
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0007 0.0036
Plasmodium falciparum glutathione reductase 0.0039 0.0072 0.7417
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0023 0.0029 0.0025
Brugia malayi hypothetical protein 0.0148 0.0368 0.2178
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Trypanosoma cruzi sugar transporter, putative 0.0047 0.0096 0.2797
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0206 0.0202
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0038 0.0307
Trypanosoma brucei p-glycoprotein 0.0016 0.001 0.0173
Entamoeba histolytica hypothetical protein 0.0038 0.0071 0.0746
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0038 0.0098
Echinococcus multilocularis abhydrolase domain containing protein 0.0041 0.008 0.0397
Onchocerca volvulus 0.0034 0.006 0.0853
Leishmania major myo-inositol/proton symporter (MIT) 0.0047 0.0096 0.2715
Onchocerca volvulus Huntingtin homolog 0.0148 0.0368 0.5473
Brugia malayi Major Facilitator Superfamily protein 0.0047 0.0096 0.0555
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.025 0.1231
Echinococcus multilocularis mitogen activated protein kinase 14 0.0139 0.0343 0.1705
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0067 0.057
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.032 0.0833 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0209 0.1247
Onchocerca volvulus 0.0047 0.0096 0.1394
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0042 0.0197
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0023 0.0029 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0833 1
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0121 0.141
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0224
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0047 0.0096 0.0477
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0071 0.4154
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0048 0.0266
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0042 0.014
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0005 0.0015
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0016 0.001 0.0173
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0023 0.0029 0.023
Trypanosoma cruzi multidrug resistance protein E, putative 0.0016 0.001 0.0285
Brugia malayi calpain 5 0.0021 0.0024 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Schistosoma mansoni intermediate filament proteins 0.003 0.0048 0.0222
Leishmania major pentamidine resistance protein 1 0.0016 0.001 0.0173
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0056 0.0185
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0251
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0016
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0423 0.1112 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0023 0.0029 0.0025
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0024 0.0713
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0139 0.0343 1
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0007 0.0025
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0003 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0833 1
Giardia lamblia Sugar-proton symporter 0.0047 0.0096 0.111
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0038 0.1003
Onchocerca volvulus Putative transporter 0.0047 0.0096 0.1394
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0005 0.0015
Brugia malayi steroid hormone receptor 0.0028 0.0042 0.0236
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0023 0.0029 0.0752
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.0149 0.131
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0038 0.0208
Onchocerca volvulus 0.0033 0.0056 0.0797
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0077 0.0884
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0009 0.0256
Onchocerca volvulus 0.0047 0.0096 0.1394
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0042 0.0236
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0302 0.0783 0.2583
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0428 0.141
Echinococcus granulosus Ankyrin 0.0016 0.0011 0.0035
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0016 0.001 0.0173
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0118
Toxoplasma gondii sugar transporter ST2 0.0047 0.0096 0.5677
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0023 0.0029 0.023
Echinococcus granulosus death domain containing protein 0.0016 0.001 0.0034
Entamoeba histolytica protein kinase, putative 0.0022 0.0028 0.0223
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.0398
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0071 0.6538
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0042 0.0236
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.057
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0048 0.0096 0.0836
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0067 0.0063
Brugia malayi hypothetical protein 0.0015 0.0007 0.0025
Schistosoma mansoni sugar transporter 0.0047 0.0096 0.0463
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0024 0.0713
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0038 0.0342
Loa Loa (eye worm) calpain family protein 1 0.0071 0.0158 0.0942
Schistosoma mansoni hypothetical protein 0.0016 0.0011 0.0041
Loa Loa (eye worm) beta-lactamase 0.0037 0.0067 0.0398
Toxoplasma gondii thioredoxin reductase 0.0039 0.0072 0.4211
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.025 0.1475
Toxoplasma gondii sugar transporter ST3 0.0047 0.0096 0.5677
Brugia malayi MAP kinase sur-1 0.0057 0.0121 0.0704
Schistosoma mansoni glucose transporter 0.0047 0.0096 0.0463
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0096 0.111
Brugia malayi Cytochrome P450 family protein 0.0125 0.0305 0.1805
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0016 0.001 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0096 0.111
Schistosoma mansoni Replicative DNA helicase 0.0423 0.1112 0.5523
Echinococcus multilocularis solute carrier family 22 0.0047 0.0096 0.0477
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0833 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.025 0.3708
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0016
Loa Loa (eye worm) cytochrome P450 family protein 0.0125 0.0305 0.1818
Loa Loa (eye worm) major facilitator superfamily transporter 0.0047 0.0096 0.057
Schistosoma mansoni jun-related protein 0.0075 0.017 0.0831
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.057
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0096 0.111
Loa Loa (eye worm) hypothetical protein 0.005 0.0102 0.0604
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.025 0.2969
Brugia malayi N-terminal motif family protein 0.0198 0.0502 0.2981
Echinococcus multilocularis calpain 0.0021 0.0024 0.0122
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0024 0.0607
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.0149 0.0741
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.025 0.1489
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0023 0.0029 0.0025
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0071 0.1986
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0121 0.7216
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0047 0.0096 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0011 0.0037
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0186 0.0612
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.057
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0121 0.0587
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0024 0.0607
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0105 0.0611
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0042 0.0211
Loa Loa (eye worm) hypothetical protein 0.0051 0.0105 0.0626
Brugia malayi Sugar transporter family protein 0.0047 0.0096 0.0555
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0047 0.0096 0.0316
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0023 0.0029 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0096 0.111
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0023 0.0029 0.0025
Mycobacterium tuberculosis Probable reductase 0.0088 0.0206 0.0202
Onchocerca volvulus 0.0047 0.0096 0.1394
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0017 0.0013
Leishmania major glucose transporter, lmgt3 0.0047 0.0096 0.2715
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0024 0.0713
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0023 0.0029 0.0857
Schistosoma mansoni hypothetical protein 0.0016 0.0011 0.0041
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0166 0.0812
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0042 0.0236
Trypanosoma brucei glucose transporter, putative 0.0047 0.0096 0.2715
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0038 0.0208
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0042 0.014
Echinococcus multilocularis jun protein 0.0092 0.0216 0.1076
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0121 0.3525
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.002 0.1579
Mycobacterium ulcerans recombinase A 0.0118 0.0287 0.2557
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0024 0.0607
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0042 0.014
Toxoplasma gondii transporter, major facilitator family protein 0.0047 0.0096 0.5677
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0071 0.7318
Trichomonas vaginalis glucose transporter, putative 0.0047 0.0096 0.111
Schistosoma mansoni calpain (C02 family) 0.0021 0.0024 0.0107
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0077 0.0443
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0023 0.0029 0.023
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0281
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0067 0.0762
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0023 0.0029 0.0025
Echinococcus multilocularis microtubule associated protein 2 0.0756 0.201 1
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0071 0.2077
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0118 0.0287 0.0846
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0005 0.0017
Echinococcus granulosus solute carrier family 22 0.0047 0.0096 0.0316
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0024 0.0713
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0042 0.0236
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0004 0.0113
Echinococcus multilocularis 0.0023 0.0029 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0017 0.0013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0048 0.0281
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0005 0.015
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.001 0.006
Brugia malayi calpain family protein 1 0.0071 0.0158 0.0928
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0023 0.0029 0.023
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0004 0.0005
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0423 0.1112 1
Brugia malayi Pre-SET motif family protein 0.0033 0.0056 0.0317
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0056
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0121 0.0601
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0042 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0067 0.1957
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0042 0.0211
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0003 0.001
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0009 0.0256
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0156 0.039 0.0387
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0071 0.0158 0.0774
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0139 0.0343 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.057
Onchocerca volvulus 0.003 0.0048 0.0669
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0121 0.3451
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0007 0.0021
Echinococcus granulosus lamin dm0 0.003 0.0048 0.0157
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0004 0.0113
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0121 0.141
Onchocerca volvulus 0.003 0.0048 0.0669
Loa Loa (eye worm) hydrolase 0.0041 0.008 0.0474
Brugia malayi hypothetical protein 0.0047 0.0096 0.0555
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0011 0.0056
Echinococcus granulosus cytochrome P450 2K1 0.0023 0.0029 0.0097
Plasmodium vivax glutathione reductase, putative 0.0039 0.0072 0.6627

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 11.9061 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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