Detailed information for compound 1389276

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 359.38 | Formula: C17H21N5O4
  • H donors: 1 H acceptors: 4 LogP: 5.19 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)n1nc(c([n+]1[O-])NCCC1=CCCCC1)[N+](=O)[O-]
  • InChi: 1S/C17H21N5O4/c1-26-15-9-7-14(8-10-15)20-19-17(22(24)25)16(21(20)23)18-12-11-13-5-3-2-4-6-13/h5,7-10,18H,2-4,6,11-12H2,1H3
  • InChiKey: VJNCCYQQDJEHCF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0061 0.027
Echinococcus multilocularis Regulator of G protein signaling 20 0.0858 0.1573 0.1876
Echinococcus granulosus twitchin 0.0136 0.0201 0.0235
Onchocerca volvulus 0.0062 0.0061 0.0311
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0062 0.0061 0.0061
Echinococcus multilocularis oxysterol binding protein 1 0.0079 0.0092 0.0105
Brugia malayi bone morphogenetic protein type 1 receptor 0.0062 0.0061 0.0061
Schistosoma mansoni protein kinase 0.0083 0.0101 0.0097
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0079 0.0092 0.0105
Echinococcus granulosus defective proboscis extension response 0.0115 0.0161 0.0187
Echinococcus multilocularis tyrosine protein kinase csk 0.0062 0.0061 0.0067
Leishmania major protein kinase, putative 0.01 0.0133 1
Onchocerca volvulus 0.0062 0.0061 0.0311
Loa Loa (eye worm) hypothetical protein 0.0418 0.0738 0.0735
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0054 0.0054
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0052 0.0263
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0208
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0079 0.0092 0.0208
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0079 0.0092 0.4387
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0079 0.0092 0.0484
Onchocerca volvulus 0.0079 0.0092 0.0484
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0062 0.0061 0.0067
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0062 0.0061 0.0067
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0067 0.0063
Echinococcus multilocularis FL cytokine receptor 0.0062 0.0061 0.0067
Brugia malayi hypothetical protein 0.0062 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.012 0.0171 0.0167
Schistosoma mansoni serine/threonine-protein kinase 0.01 0.0133 0.0128
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Onchocerca volvulus 0.0987 0.1819 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.01 0.0133 0.0473
Trichomonas vaginalis conserved hypothetical protein 0.0858 0.1573 1
Echinococcus multilocularis pdz domain containing protein 0.0079 0.0092 0.0105
Echinococcus multilocularis oxysterol binding protein 9 0.0079 0.0092 0.0105
Entamoeba histolytica hypothetical protein 0.0183 0.0291 0.1522
Echinococcus multilocularis rac serine:threonine kinase 0.01 0.0133 0.0153
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0052 0.0049
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0858 0.1573 1
Loa Loa (eye worm) PH domain-containing protein 0.0079 0.0092 0.0089
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Leishmania major folate/biopterin transporter, putative 0.01 0.0133 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0057
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0057
Echinococcus granulosus muscleblind protein 0.018 0.0286 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0858 0.1573 1
Schistosoma mansoni hypothetical protein 0.0418 0.0738 0.0734
Schistosoma mansoni nephrin 0.012 0.0171 0.0166
Echinococcus granulosus expressed protein 0.0858 0.1573 0.1876
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1527 0.1821
Leishmania major protein kinase, putative 0.01 0.0133 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0062 0.0061 0.0067
Trypanosoma brucei protein kinase, putative 0.0083 0.0101 0.5613
Schistosoma mansoni regulator of G protein signaling 0.0858 0.1573 0.157
Schistosoma mansoni hypothetical protein 0.0079 0.0092 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.4054 0.7652 0.7651
Echinococcus granulosus GRB2 associated binding protein 3 0.0079 0.0092 0.0105
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0001
Brugia malayi Tyrosine-protein kinase abl-1 0.0062 0.0061 0.0061
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1527 0.1524
Echinococcus granulosus tyrosine protein kinase 0.0062 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Entamoeba histolytica hypothetical protein 0.0183 0.0291 0.1522
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0062 0.0061 0.0067
Brugia malayi Receptor family ligand binding region containing protein 0.0062 0.0061 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0101 0.0525
Loa Loa (eye worm) PXA domain-containing protein 0.0858 0.1573 0.157
Entamoeba histolytica PH domain containing protein kinase, putative 0.01 0.0133 0.0473
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0083 0.0101 0.5533
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0057
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0067 0.0075
Onchocerca volvulus 0.0058 0.0054 0.027
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0079 0.0092 0.0105
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0057
Entamoeba histolytica protein kinase domain containing protein 0.0083 0.0101 0.0262
Trypanosoma brucei rac serine-threonine kinase, putative 0.01 0.0133 1
Trichomonas vaginalis conserved hypothetical protein 0.0858 0.1573 1
Echinococcus multilocularis axis inhibition protein axin 0.0858 0.1573 0.1876
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1527 0.1821
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0082 0.5
Echinococcus multilocularis regulator of G protein signaling 3 0.0858 0.1573 0.1876
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0057
Schistosoma mansoni goodpasture antigen-binding protein 0.0079 0.0092 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0061 0.027
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0169 0.0713
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0024 0.0024
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0062 0.0061 0.027
Loa Loa (eye worm) TK protein kinase 0.0062 0.0061 0.0057
Echinococcus granulosus cytohesin 1 0.0079 0.0092 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.0291 0.1751
Toxoplasma gondii hypothetical protein 0.0079 0.0092 0.4387
Trichomonas vaginalis protein transport protein sec7, putative 0.0079 0.0092 0.0472
Brugia malayi intermediate filament protein 0.0033 0.0005 0.0005
Loa Loa (eye worm) syntrophin-1 0.0079 0.0092 0.0089
Echinococcus multilocularis raf serine:threonine protein kinase 0.0062 0.0061 0.0067
Onchocerca volvulus 0.0062 0.0061 0.0311
Trypanosoma brucei PH domain containing protein, putative 0.0079 0.0092 0.4387
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Echinococcus granulosus expressed conserved protein 0.0112 0.0155 0.018
Schistosoma mansoni hypothetical protein 0.0079 0.0092 0.0088
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0083 0.0101 0.5613
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0169 0.0196
Onchocerca volvulus 0.0058 0.0052 0.0263
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0062 0.0061 0.0067
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.004 0.0042
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0062 0.0061 0.0057
Echinococcus granulosus serine/threonine protein kinase 0.01 0.0133 0.0153
Loa Loa (eye worm) hypothetical protein 0.0418 0.0738 0.0735
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0062 0.0061 0.0067
Trypanosoma cruzi rac serine-threonine kinase, putative 0.01 0.0133 1
Brugia malayi probable spectrin beta chain 0.0079 0.0092 0.0092
Echinococcus granulosus tyrosine kinase 0.0062 0.0061 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Echinococcus multilocularis protein kinase 0.0062 0.0061 0.0067
Brugia malayi regulator of G-protein signaling egl-10 0.0858 0.1573 0.1573
Loa Loa (eye worm) hypothetical protein 0.0119 0.0169 0.0165
Echinococcus granulosus activin receptor type 0.0083 0.0101 0.0116
Onchocerca volvulus 0.0062 0.0061 0.0311
Entamoeba histolytica hypothetical protein 0.0079 0.0092 0.0208
Brugia malayi hypothetical protein 0.0032 0.0005 0.0005
Entamoeba histolytica protein kinase, putative 0.01 0.0133 0.0473
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0079 0.0092 0.0089
Onchocerca volvulus 0.0062 0.0061 0.0311
Echinococcus multilocularis tyrosine protein kinase Srms 0.0062 0.0061 0.0067
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0005 0.0005
Brugia malayi SH2 domain containing protein 0.0062 0.0061 0.0061
Schistosoma mansoni ephrin receptor 0.0067 0.0071 0.0066
Entamoeba histolytica hypothetical protein 0.0858 0.1573 1
Onchocerca volvulus 0.0033 0.0005 0.0001
Echinococcus multilocularis expressed conserved protein 0.0112 0.0155 0.018
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0062 0.0061 0.0067
Brugia malayi hypothetical protein 0.0418 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.001
Leishmania major serine/threonine-protein kinase a, putative 0.01 0.0133 1
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Echinococcus granulosus tyrosine protein kinase Srms 0.0062 0.0061 0.0067
Echinococcus multilocularis tyrosine kinase 0.0062 0.0061 0.0067
Onchocerca volvulus 0.0062 0.0061 0.0311
Loa Loa (eye worm) hypothetical protein 0.0051 0.004 0.0036
Echinococcus multilocularis Immunoglobulin 0.0115 0.0161 0.0187
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0092
Onchocerca volvulus 0.0418 0.0738 0.4041
Echinococcus granulosus myotubularin protein 13 0.0079 0.0092 0.0105
Echinococcus granulosus calcium dependent secretion activator 1 0.0079 0.0092 0.0105
Loa Loa (eye worm) hypothetical protein 0.0858 0.1573 0.157
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0115 0.0161 0.0187
Schistosoma mansoni regulator of G protein signaling 0.0858 0.1573 0.157
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.0291 0.1751
Loa Loa (eye worm) AUR protein kinase 0.0083 0.0101 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0061 0.027
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0052 0.0048
Echinococcus multilocularis neuroglian 0.0115 0.0161 0.0187
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0079 0.0092 0.0089
Schistosoma mansoni hypothetical protein 0.0049 0.0036 0.0032
Echinococcus multilocularis c src tyrosine kinase 0.0062 0.0061 0.0067
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0062 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Schistosoma mansoni hypothetical protein 0.0079 0.0092 0.0088
Loa Loa (eye worm) hypothetical protein 0.0418 0.0738 0.0735
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0062 0.0061 0.0067
Plasmodium falciparum PH domain-containing protein, putative 0.0079 0.0092 0.4387
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Schistosoma mansoni oxysterol-binding protein 1 0.0079 0.0092 0.0088
Schistosoma mansoni growth factor receptor-bound protein 0.0079 0.0092 0.0088
Schistosoma mansoni protein kinase 0.0083 0.0101 0.0096
Trichomonas vaginalis protein kinase atn1, putative 0.0062 0.0061 0.027
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0062 0.0061 0.0056
Schistosoma mansoni hypothetical protein 0.0079 0.0092 0.0088
Brugia malayi Dynamin 0.0079 0.0092 0.0092
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Schistosoma mansoni hypothetical protein 0.0569 0.1024 0.102
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0079 0.0092 0.0088
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.01 0.0133 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0062 0.0061 0.0057
Echinococcus granulosus kinase suppressor of Ras 1 0.0062 0.0061 0.0067
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0079 0.0092 0.0105
Loa Loa (eye worm) TK protein kinase 0.0062 0.0061 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0061 0.027
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0082 0.0093
Toxoplasma gondii phosphatidylinositol transfer protein 0.0079 0.0092 0.4387
Schistosoma mansoni protein kinase 0.0062 0.0061 0.0056
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0062 0.0061 0.0067
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0062 0.0061 0.0067
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0062 0.0061 0.0067
Brugia malayi CHE-14 protein 0.0051 0.004 0.004
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.0374 0.0442
Echinococcus granulosus G protein coupled receptor kinase 1 0.3196 0.6021 0.7193
Echinococcus granulosus epidermal growth factor receptor 0.0062 0.0061 0.0067
Echinococcus multilocularis regulator of G protein signaling 7 0.0858 0.1573 0.1876
Toxoplasma gondii hypothetical protein 0.0079 0.0092 0.4387
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0062 0.0061 0.0067
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0025 0.0025
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0169 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0208
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Loa Loa (eye worm) hypothetical protein 0.018 0.0286 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Schistosoma mansoni regulator of G protein signaling 0.0858 0.1573 0.157
Onchocerca volvulus Protein melted homolog 0.0079 0.0092 0.0484
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Echinococcus granulosus Pleckstrin y 0.0079 0.0092 0.0105
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Echinococcus multilocularis receptor type guanylyl cyclase 0.0062 0.0061 0.0067
Entamoeba histolytica hypothetical protein 0.0079 0.0092 0.0208
Brugia malayi A-kinase anchor protein 10, precursor 0.0858 0.1573 0.1573
Brugia malayi plexin A 0.117 0.2168 0.2168
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Echinococcus granulosus geminin 0.0205 0.0332 0.0391
Trypanosoma cruzi Protein kinase B 0.01 0.0133 1
Entamoeba histolytica protein kinase, putative 0.0083 0.0101 0.0262
Entamoeba histolytica cell surface protease gp63, putative 0.0183 0.0291 0.1522
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.01 0.0133 0.0731
Onchocerca volvulus 0.0062 0.0061 0.0311
Entamoeba histolytica protein kinase domain containing protein 0.0083 0.0101 0.0266
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Entamoeba histolytica protein kinase, putative 0.01 0.0133 0.0473
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0079 0.0092 0.0472
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0062 0.0061 0.0061
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0208
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0062 0.0061 0.0067
Brugia malayi hypothetical protein 0.0062 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase csk 0.0062 0.0061 0.0067
Echinococcus granulosus axis inhibition protein axin 0.0858 0.1573 0.1876
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0208
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0062 0.0061 0.0061
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0079 0.0092 0.0088
Brugia malayi Sema domain containing protein 0.0418 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0057
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0062 0.0061 0.0067
Loa Loa (eye worm) RGS-3 protein 0.0858 0.1573 0.157
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Brugia malayi Regulator of G protein signaling domain containing protein 0.0858 0.1573 0.1573
Loa Loa (eye worm) TK protein kinase 0.0062 0.0061 0.0057
Entamoeba histolytica protein kinase, putative 0.01 0.0133 0.0473
Schistosoma mansoni vav2 0.0079 0.0092 0.0088
Brugia malayi mbt repeat family protein 0.0058 0.0052 0.0052
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0079 0.0092 0.4387
Schistosoma mansoni survival motor neuron protein 0.0058 0.0054 0.0049
Brugia malayi hypothetical protein 0.0858 0.1573 0.1573
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Echinococcus multilocularis tyrosine protein kinase Blk 0.0062 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.018 0.0286 0.0282
Echinococcus multilocularis tyrosine protein kinase csk 0.0062 0.0061 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Schistosoma mansoni tyrosine protein kinase 0.0062 0.0061 0.0056
Loa Loa (eye worm) hypothetical protein 0.0858 0.1573 0.157
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Loa Loa (eye worm) MBCTL1 0.0066 0.0067 0.0064
Echinococcus multilocularis expressed protein 0.0858 0.1573 0.1876
Brugia malayi hypothetical protein 0.0079 0.0092 0.0092
Leishmania major protein kinase, putative 0.0083 0.0101 0.5533
Echinococcus multilocularis dynamin 1 0.0079 0.0092 0.0105
Schistosoma mansoni centaurin alpha 0.0079 0.0092 0.0088
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Brugia malayi PXA domain containing protein 0.0858 0.1573 0.1573
Onchocerca volvulus 0.0079 0.0092 0.0484
Entamoeba histolytica PH domain containing protein 0.0079 0.0092 0.0208
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0079 0.0092 0.4387
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0062 0.0061 0.0057
Brugia malayi SRC-1 0.0062 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Entamoeba histolytica protein kinase, putative 0.01 0.0133 0.0473
Trypanosoma cruzi hypothetical protein 0.0079 0.0092 0.4387
Brugia malayi Protein kinase domain containing protein 0.01 0.0133 0.0133
Schistosoma mansoni serine/threonine protein kinase 0.4054 0.7652 0.7651
Schistosoma mansoni syntrophin 0.0079 0.0092 0.0088
Brugia malayi integrin-linked kinase 0.0062 0.0061 0.0061
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0062 0.0061 0.0067
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0067 0.0075
Echinococcus multilocularis muscleblind protein 0.018 0.0286 0.0336
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0079 0.0092 0.0105
Echinococcus multilocularis transcription factor collier 0.0183 0.0291 0.0343
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0486 0.0575
Echinococcus multilocularis transfer RNA-Thr 0.0062 0.0061 0.0067
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0079 0.0092 0.0472
Leishmania major protein kinase, putative 0.0083 0.0101 0.5613
Entamoeba histolytica protein kinase, putative 0.01 0.0133 0.0473
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0079 0.0092 0.0472
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Echinococcus granulosus tyrosine protein kinase HCK 0.0062 0.0061 0.0067
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0858 0.1573 0.157
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0172 0.0168
Loa Loa (eye worm) serine/threonine protein kinase 0.0062 0.0061 0.0057
Entamoeba histolytica ARF GTPase activating protein, putative 0.0079 0.0092 0.0208
Echinococcus multilocularis GRB2 associated binding protein 3 0.0079 0.0092 0.0105
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0057
Brugia malayi serine/threonine protein kinase 6 0.0083 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Brugia malayi Bromodomain containing protein 0.0046 0.0031 0.0031
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0079 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.012 0.0171 0.0167
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0092
Brugia malayi mbt repeat family protein 0.0058 0.0052 0.0052
Entamoeba histolytica PH domain containing protein kinase, putative 0.01 0.0133 0.0473
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0061 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.0291 0.1751
Brugia malayi hypothetical protein 0.0062 0.0061 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0061 0.0056
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0067 0.0071 0.0079
Loa Loa (eye worm) oxysterol binding protein 0.0079 0.0092 0.0089
Brugia malayi Regulator of G protein signaling domain containing protein 0.0858 0.1573 0.1573
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0061 0.027
Echinococcus multilocularis protein kinase 0.0062 0.0061 0.0067
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.01 0.0133 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0062 0.0061 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.5289 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0057
Trypanosoma cruzi NIMA-related kinase, putative 0.01 0.0133 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0062 0.0061 0.0057
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0079 0.0092 0.4387
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0082 0.0078
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Schistosoma mansoni protein kinase 0.0062 0.0061 0.0056
Loa Loa (eye worm) TK protein kinase 0.0062 0.0061 0.0057
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Schistosoma mansoni zinc finger protein 0.0079 0.0092 0.0088
Entamoeba histolytica protein kinase, putative 0.01 0.0133 0.0473
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Echinococcus granulosus ephrin type A receptor 4 A 0.0062 0.0061 0.0067
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0183 0.0291 0.1751
Brugia malayi Immunoglobulin I-set domain containing protein 0.0177 0.0279 0.0279
Schistosoma mansoni hypothetical protein 0.0418 0.0738 0.0734
Trypanosoma cruzi rac serine-threonine kinase, putative 0.01 0.0133 1
Echinococcus multilocularis integrin linked protein kinase 0.0062 0.0061 0.0067
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Echinococcus multilocularis tyrosine kinase 0.0062 0.0061 0.0067
Entamoeba histolytica hypothetical protein 0.0183 0.0291 0.1522
Brugia malayi Probable exocyst complex component Sec5 0.0183 0.0291 0.0291
Schistosoma mansoni ephrin receptor 0.0062 0.0061 0.0056
Trypanosoma cruzi NIMA-related kinase, putative 0.01 0.0133 1
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0079 0.0092 0.0105
Echinococcus multilocularis G protein coupled receptor kinase 1 0.3196 0.6021 0.7193
Schistosoma mansoni axis inhibition protein axin 0.0858 0.1573 0.157
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Echinococcus multilocularis tyrosine protein kinase shark 0.0062 0.0061 0.0067
Echinococcus multilocularis semaphorin 5B 0.0418 0.0738 0.0877
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0057
Onchocerca volvulus outspread protein homolog 0.0079 0.0092 0.0484
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Schistosoma mansoni dynamin 0.0079 0.0092 0.0088
Echinococcus multilocularis kinase suppressor of Ras 1 0.0062 0.0061 0.0067
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Echinococcus granulosus activated cdc42 kinase 1 0.0062 0.0061 0.0067
Echinococcus multilocularis Pleckstrin y 0.0079 0.0092 0.0105
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0079 0.0092 0.0092
Toxoplasma gondii aurora kinase 0.0083 0.0101 0.5533
Loa Loa (eye worm) hypothetical protein 0.0858 0.1573 0.157
Trypanosoma cruzi hypothetical protein 0.0079 0.0092 0.4387
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Echinococcus granulosus Protein patched homolog 1 0.0051 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0858 0.1573 0.157
Echinococcus multilocularis regulator of G protein signaling 3 0.0858 0.1573 0.1876
Schistosoma mansoni serine/threonine RGC 0.0062 0.0061 0.0056
Loa Loa (eye worm) sema domain-containing protein 0.0418 0.0738 0.0735
Echinococcus granulosus axis inhibition protein axin 0.0858 0.1573 0.1876
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Loa Loa (eye worm) protein kinase domain-containing protein 0.0062 0.0061 0.0057
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0062 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0057
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0062 0.0061 0.0057
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Schistosoma mansoni protein kinase 0.0062 0.0061 0.0056
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0062 0.0061 0.0056
Echinococcus multilocularis epidermal growth factor receptor 0.0062 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.0049 0.0036 0.0033
Brugia malayi Plekhf2 protein 0.0079 0.0092 0.0092
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0079 0.0092 0.0208
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Echinococcus granulosus tyrosine protein kinase Lyn 0.0083 0.0101 0.0116
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0062 0.0061 0.0057
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0062 0.0061 0.0056
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Loa Loa (eye worm) cytohesin 3 0.0079 0.0092 0.0089
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0079 0.0092 0.0208
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.004 0.0036
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Brugia malayi Muscleblind-like protein 0.018 0.0286 0.0286
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Echinococcus multilocularis calcium dependent secretion activator 1 0.0079 0.0092 0.0105
Loa Loa (eye worm) hypothetical protein 0.0066 0.0067 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0061 0.027
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Trypanosoma cruzi hypothetical protein 0.0079 0.0092 0.4387
Entamoeba histolytica PH domain containing protein kinase, putative 0.01 0.0133 0.0473
Brugia malayi DNA-binding protein LAG-1 0.0183 0.0291 0.0291
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0208
Brugia malayi Sema domain containing protein 0.0418 0.0738 0.0738
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0486 0.0575
Schistosoma mansoni regulator of G protein signaling 0.0858 0.1573 0.157
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0088 0.0084
Leishmania major hypothetical protein, conserved 0.0079 0.0092 0.4387
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0092
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Echinococcus multilocularis heat shock protein 70 0.0062 0.0061 0.0067
Schistosoma mansoni zinc finger protein 0.0079 0.0092 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Brugia malayi MAX-1A 0.0079 0.0092 0.0092
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0079 0.0092 0.0088
Echinococcus multilocularis Immunoglobulin 0.0115 0.0161 0.0187
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Echinococcus multilocularis tyrosine protein kinase pr2 0.0062 0.0061 0.0067
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0079 0.0092 0.0105
Loa Loa (eye worm) hypothetical protein 0.0183 0.0291 0.0288
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0062 0.0061 0.0067
Echinococcus multilocularis Rho GTPase activating protein 24 0.0079 0.0092 0.0105
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0177 0.0279 0.0276
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0062 0.0061 0.0067
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0183 0.0291 0.1751
Echinococcus granulosus transcription factor collier 0.0183 0.0291 0.0343
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0079 0.0092 0.0208
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Echinococcus multilocularis exocyst complex component 2 0.0183 0.0291 0.0343
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0205 0.0332 0.0328
Echinococcus multilocularis oxysterol binding protein 3 0.0079 0.0092 0.0105
Trichomonas vaginalis centaurin alpha, putative 0.0079 0.0092 0.0472
Echinococcus granulosus regulator of G protein signaling 7 0.0858 0.1573 0.1876
Schistosoma mansoni semaphorin 5-related 0.0418 0.0738 0.0734
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0083 0.0101 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Echinococcus granulosus tyrosine protein kinase Fyn 0.0062 0.0061 0.0067
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0115 0.0161 0.0187
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0062 0.0061 0.0067
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0082 0.0078
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0082 0.5
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0266 0.0312
Echinococcus multilocularis tyrosine protein kinase HCK 0.0062 0.0061 0.0067
Schistosoma mansoni protein kinase 0.0062 0.0061 0.0056
Trichomonas vaginalis centaurin gamma, putative 0.0079 0.0092 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.0291 0.1751
Loa Loa (eye worm) hypothetical protein 0.0115 0.0161 0.0157
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0005 0.0001
Toxoplasma gondii protein kinase domain-containing protein 0.01 0.0133 1
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0057
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0079 0.0092 0.0208
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0052 0.0057
Brugia malayi C-terminal src kinase protein 1 0.0062 0.0061 0.0061
Schistosoma mansoni protein kinase 0.0083 0.0101 0.0097
Echinococcus multilocularis protein dispatched 1 0.0058 0.0054 0.0059
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0052 0.0048
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0062 0.0061 0.027
Schistosoma mansoni rho gtpase activating protein 0.0079 0.0092 0.0088
Echinococcus multilocularis hypothetical protein 0.0418 0.0738 0.0877
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.4431 0.8369 0.8369
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0062 0.0061 0.0067
Echinococcus granulosus dynamin 1 0.0079 0.0092 0.0105
Echinococcus granulosus protein tyrosine kinase 0.0062 0.0061 0.0067
Trichomonas vaginalis AGC family protein kinase 0.0062 0.0061 0.027
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.008 0.009
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0079 0.0092 0.0105
Loa Loa (eye worm) hypothetical protein 0.0115 0.0161 0.0157
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0082 0.2967
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Onchocerca volvulus 0.0062 0.0061 0.0311
Echinococcus multilocularis plexin a4 0.117 0.2168 0.2586
Echinococcus multilocularis Oxysterol binding protein 11 0.0079 0.0092 0.0105
Loa Loa (eye worm) hypothetical protein 0.012 0.0171 0.0167
Schistosoma mansoni serine/threonine-protein kinase 0.01 0.0133 0.0128
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0057
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Trypanosoma cruzi hypothetical protein 0.0079 0.0092 0.4387
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Echinococcus granulosus c src tyrosine kinase 0.0062 0.0061 0.0067
Echinococcus multilocularis cytohesin 1 0.0079 0.0092 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Plasmodium falciparum oxysterol-binding protein, putative 0.0079 0.0092 0.4387
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0088 0.01
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0088 0.0084
Entamoeba histolytica protein kinase , putative 0.0083 0.0101 0.0262
Loa Loa (eye worm) hypothetical protein 0.0062 0.0062 0.0058
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0079 0.0092 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0208
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0062 0.0061 0.0067
Echinococcus granulosus Oxysterol binding protein 11 0.0079 0.0092 0.0105
Trichomonas vaginalis centaurin/arf, putative 0.0079 0.0092 0.0472
Loa Loa (eye worm) TK/EGFR protein kinase 0.0062 0.0061 0.0057
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0079 0.0092 0.4387
Echinococcus granulosus retinal guanylyl cyclase 2 0.0062 0.0061 0.0067
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0079 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0418 0.0738 0.0735
Onchocerca volvulus 0.0079 0.0092 0.0484
Echinococcus multilocularis axis inhibition protein axin 0.0858 0.1573 0.1876
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0079 0.0092 0.0105
Echinococcus granulosus insulin receptor 0.0062 0.0061 0.0067
Echinococcus granulosus tyrosine protein kinase Fyn 0.0062 0.0061 0.0067
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0183 0.0291 0.1751
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.01 0.0133 1
Echinococcus granulosus tyrosine kinase 0.0062 0.0061 0.0067
Loa Loa (eye worm) plexin A 0.117 0.2168 0.2165
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0062 0.0061 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0088 0.0084
Loa Loa (eye worm) AUR protein kinase 0.0083 0.0101 0.0097
Entamoeba histolytica hypothetical protein 0.0858 0.1573 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0062 0.0061 0.0057
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0208
Brugia malayi Furin-like cysteine rich region family protein 0.0062 0.0061 0.0061
Echinococcus multilocularis ephrin type A receptor 4 A 0.0062 0.0061 0.0067
Echinococcus granulosus semaphorin 5B 0.0418 0.0738 0.0877
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.01 0.0133 1
Loa Loa (eye worm) hypothetical protein 0.0183 0.0291 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0858 0.1573 1
Echinococcus granulosus protein kinase 0.0062 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Echinococcus granulosus epidermal growth factor receptor 0.0062 0.0061 0.0067
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0067 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Brugia malayi Syntrophin-1 0.0079 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Entamoeba histolytica hypothetical protein 0.01 0.0133 0.0473
Echinococcus granulosus beta-adrenergic receptor kinase 0.4054 0.7652 0.9142
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Loa Loa (eye worm) hypothetical protein 0.0418 0.0738 0.0735
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0083 0.0101 0.0115
Loa Loa (eye worm) RGC/RGC protein kinase 0.0062 0.0061 0.0057
Brugia malayi Pleckstrin Homology Domain 0.0079 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0183 0.0291 0.0287
Echinococcus granulosus plexin a4 0.117 0.2168 0.2586
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0062 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.0033 0.0005 0.0001
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Echinococcus granulosus Rho GTPase activating protein 24 0.0079 0.0092 0.0105
Loa Loa (eye worm) sema domain-containing protein 0.0418 0.0738 0.0735
Trichomonas vaginalis hypothetical protein 0.0079 0.0092 0.0472
Brugia malayi hypothetical protein 0.0418 0.0738 0.0738
Echinococcus multilocularis beta adrenergic receptor kinase 0.4054 0.7652 0.9142
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.01 0.0133 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0858 0.1573 0.1876
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0061 0.027
Schistosoma mansoni hypothetical protein 0.0062 0.0061 0.0056
Entamoeba histolytica hypothetical protein 0.0079 0.0092 0.0208
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Schistosoma mansoni myotubularin-related protein 0.0079 0.0092 0.0088
Echinococcus multilocularis regulator of G protein signaling 7 0.0858 0.1573 0.1876
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.004 0.0134
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.01 0.0133 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0062 0.0061 0.0056
Echinococcus granulosus tyrosine protein kinase Fyn 0.0062 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.0115 0.0161 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.0291 0.1751
Trichomonas vaginalis centaurin/arf, putative 0.0079 0.0092 0.0472
Loa Loa (eye worm) SRC-1 0.0062 0.0061 0.0057
Echinococcus granulosus beta 1 syntrophin 0.0079 0.0092 0.0105
Echinococcus multilocularis Ras associated and pleckstrin y 0.0079 0.0092 0.0105
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0062 0.0061 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0092 0.4387
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0082 0.5
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Trichomonas vaginalis centaurin beta, putative 0.0079 0.0092 0.0472
Brugia malayi Bromodomain containing protein 0.0091 0.0115 0.0115
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0052 0.0057
Onchocerca volvulus 0.0079 0.0092 0.0484
Echinococcus granulosus exocyst complex component 2 0.0183 0.0291 0.0343
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0062 0.0061 0.0067
Echinococcus granulosus tyrosine protein kinase csk 0.0062 0.0061 0.0067
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0266 0.0312
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Loa Loa (eye worm) TK protein kinase 0.0062 0.0061 0.0057
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Entamoeba histolytica hypothetical protein 0.0079 0.0092 0.0208
Brugia malayi Uncoordinated protein 104 0.0079 0.0092 0.0092
Trichomonas vaginalis protein tyrosine kinase, putative 0.0062 0.0061 0.027
Brugia malayi hypothetical protein 0.012 0.0171 0.0171
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0062 0.0061 0.0067
Schistosoma mansoni protein kinase 0.0062 0.0061 0.0056
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0082 0.5
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0079 0.0092 0.0208
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0052 0.0057
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0032 0.0027
Schistosoma mansoni z-protein (S1r protein) 0.0858 0.1573 0.157
Loa Loa (eye worm) hypothetical protein 0.0286 0.0486 0.0482
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0079 0.0092 0.0089
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Loa Loa (eye worm) TK/ACK protein kinase 0.0062 0.0061 0.0057
Loa Loa (eye worm) TK/Met protein kinase 0.0062 0.0061 0.0057
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Entamoeba histolytica hypothetical protein 0.0858 0.1573 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0088 0.0084
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0858 0.1573 0.157
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0079 0.0092 0.4387
Echinococcus multilocularis regulator of G protein signaling 0.0858 0.1573 0.1876
Entamoeba histolytica hypothetical protein 0.01 0.0133 0.0473
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0092
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0079 0.0092 0.0105
Schistosoma mansoni hypothetical protein 0.0205 0.0332 0.0328
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0083 0.0101 0.5613
Onchocerca volvulus 0.0079 0.0092 0.0484
Echinococcus multilocularis tyrosine protein kinase Abl 0.0062 0.0061 0.0067
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0858 0.1573 0.157
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0079 0.0092 0.0105
Echinococcus granulosus tyrosine kinase 0.0062 0.0061 0.0067
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0858 0.1573 0.1876
Onchocerca volvulus 0.0062 0.0061 0.0311
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0062 0.0061 0.0067
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0062 0.0061 0.0056
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Schistosoma mansoni protein kinase 0.0083 0.0101 0.0097
Echinococcus multilocularis pleckstrin y domain containing family A 0.0079 0.0092 0.0105
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Trichomonas vaginalis protein transport protein sec7, putative 0.0079 0.0092 0.0472
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0101 0.0096
Schistosoma mansoni hypothetical protein 0.0049 0.0036 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Schistosoma mansoni protein tyrosine kinase 0.0062 0.0061 0.0056
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0062 0.0061 0.0061
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0062 0.0061 0.0057
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0025 0.0025
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Toxoplasma gondii AtPH1 family protein 0.0079 0.0092 0.4387
Loa Loa (eye worm) uncoordinated protein 104 0.0079 0.0092 0.0089
Giardia lamblia Aurora kinase 0.0083 0.0101 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0062 0.0061 0.0067
Echinococcus granulosus raf serine:threonine protein kinase 0.0062 0.0061 0.0067
Brugia malayi Dynamin 0.0079 0.0092 0.0092
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.4431 0.8369 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0062 0.0061 0.0061
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0024 0.0024
Echinococcus granulosus tyrosine protein kinase Blk 0.0062 0.0061 0.0067
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0092
Echinococcus granulosus oxysterol binding protein 9 0.0079 0.0092 0.0105
Loa Loa (eye worm) hypothetical protein 0.0183 0.0291 0.0288
Brugia malayi Cadps2 protein 0.0079 0.0092 0.0092
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Brugia malayi PXA domain containing protein 0.0858 0.1573 0.1573
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0052 0.0048
Echinococcus granulosus regulator of G protein signaling 3 0.0858 0.1573 0.1876
Schistosoma mansoni hypothetical protein 0.0049 0.0036 0.0032
Schistosoma mansoni hypothetical protein 0.0058 0.0054 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0088 0.0084
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0183 0.0291 0.0288
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0062 0.0061 0.0067
Brugia malayi Guanylyl cyclase protein 23 0.0062 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0062 0.0061 0.0067
Echinococcus granulosus neuroglian 0.0115 0.0161 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Onchocerca volvulus 0.0062 0.0061 0.0311
Loa Loa (eye worm) hypothetical protein 0.0085 0.0105 0.0102
Trypanosoma cruzi hypothetical protein 0.0079 0.0092 0.4387
Echinococcus multilocularis insulin receptor 0.0062 0.0061 0.0067
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0062 0.0061 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Entamoeba histolytica tyrosin kinase, putative 0.0245 0.0409 0.2303
Echinococcus granulosus retinal guanylyl cyclase 2 0.0062 0.0061 0.0067
Echinococcus multilocularis Pleckstrin y 0.0079 0.0092 0.0105
Echinococcus granulosus pleckstrin y domain containing family A 0.0079 0.0092 0.0105
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0079 0.0092 0.0105
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0079 0.0092 0.0472
Echinococcus granulosus tyrosine protein kinase csk 0.0062 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.0569 0.1024 0.1021
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0083 0.0101 0.0262
Plasmodium falciparum serine/threonine protein kinase, putative 0.0083 0.0101 0.5533
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0062 0.0061 0.027
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0115 0.0161 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0858 0.1573 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.012 0.0171 0.0171
Echinococcus granulosus pdz domain containing protein 0.0079 0.0092 0.0105
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0083 0.0101 0.0262
Echinococcus granulosus tyrosine protein kinase ABL1 0.0062 0.0061 0.0067
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Brugia malayi Raf kinase 0.0062 0.0061 0.0061
Schistosoma mansoni plexin 0.0569 0.1024 0.102
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.01 0.0133 1
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0061 0.0056
Loa Loa (eye worm) TK protein kinase 0.0062 0.0061 0.0057
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0115 0.0161 0.0156
Entamoeba histolytica protein kinase domain containing protein 0.0245 0.0409 0.2303
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Schistosoma mansoni axis inhibition protein axin 0.0858 0.1573 0.157
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Entamoeba histolytica PH domain containing protein 0.0079 0.0092 0.0208
Schistosoma mansoni plexin 0.0987 0.1819 0.1816
Echinococcus granulosus oxysterol binding protein 3 0.0079 0.0092 0.0105
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.4431 0.8369 0.8369
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0079 0.0092 0.0484
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0079 0.0092 0.0105
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Schistosoma mansoni patched 1 0.0051 0.004 0.0035
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0079 0.0092 0.4387
Brugia malayi Variant SH3 domain containing protein 0.0079 0.0092 0.0092
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.004 0.0042
Brugia malayi Oxysterol binding protein 0.0079 0.0092 0.0092
Onchocerca volvulus 0.0062 0.0061 0.0311
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Loa Loa (eye worm) hypothetical protein 0.0115 0.0161 0.0157
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.0374 0.0442
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.01 0.0133 1
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0858 0.1573 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0083 0.0101 0.5613
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0057
Echinococcus granulosus DCC interacting protein 13 beta 0.0079 0.0092 0.0105
Onchocerca volvulus 0.0062 0.0061 0.0311
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Schistosoma mansoni hypothetical protein 0.0049 0.0036 0.0032
Plasmodium vivax PH domain containing protein 0.0079 0.0092 0.4387
Brugia malayi regulator of G-protein signaling rgs-7 0.0858 0.1573 0.1573
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Loa Loa (eye worm) TK protein kinase 0.0062 0.0061 0.0057
Echinococcus multilocularis tyrosine protein kinase csk 0.0062 0.0061 0.0067
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.01 0.0133 1
Brugia malayi IPT/TIG domain containing protein 0.0183 0.0291 0.0291
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0062 0.0061 0.0057
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Loa Loa (eye worm) TK/INSR protein kinase 0.0062 0.0061 0.0057
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0079 0.0092 0.0088
Schistosoma mansoni hypothetical protein 0.0183 0.0291 0.0287
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.01 0.0133 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0062 0.0061 0.0057
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0062 0.0061 0.0311
Entamoeba histolytica protein kinase, putative 0.01 0.0133 0.0473
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Schistosoma mansoni oxysterol-binding protein 1 0.0079 0.0092 0.0088
Entamoeba histolytica PH domain containing protein 0.0079 0.0092 0.0208
Brugia malayi Variant SH3 domain containing protein 0.0079 0.0092 0.0092
Echinococcus granulosus regulator of G protein signaling 7 0.0858 0.1573 0.1876
Loa Loa (eye worm) TK/FAK protein kinase 0.0062 0.0061 0.0057
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0062 0.0061 0.0067
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Entamoeba histolytica PH domain containing protein kinase, putative 0.01 0.0133 0.0473
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0092
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0062 0.0061 0.0311
Loa Loa (eye worm) hypothetical protein 0.0058 0.0052 0.0049
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0079 0.0092 0.4387
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0101 0.0525
Brugia malayi SH2 domain containing protein 0.0062 0.0061 0.0061
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.4431 0.8369 0.8369
Echinococcus granulosus tyrosine protein kinase Src64B 0.0062 0.0061 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.0291 0.1751
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0083 0.0101 0.0115
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Entamoeba histolytica hypothetical protein 0.0183 0.0291 0.1522
Echinococcus multilocularis G protein coupled receptor kinase 6 0.4431 0.8369 1
Trypanosoma brucei protein kinase, putative 0.01 0.0133 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0062 0.0061 0.027
Loa Loa (eye worm) hypothetical protein 0.0239 0.0397 0.0393
Brugia malayi serine/threonine-protein kinase 6 0.0083 0.0101 0.0101
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0183 0.0291 0.1751
Brugia malayi Oxysterol-binding protein 0.0079 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0858 0.1573 0.157
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Brugia malayi Fibronectin type III domain containing protein 0.012 0.0171 0.0171
Echinococcus multilocularis activin receptor type 0.0083 0.0101 0.0116
Echinococcus granulosus Immunoglobulin 0.0115 0.0161 0.0187
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0169 0.0196
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Echinococcus granulosus integrin linked protein kinase 0.0062 0.0061 0.0067
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0079 0.0092 0.0105
Echinococcus granulosus tyrosine protein kinase Src42A 0.0062 0.0061 0.0067
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0082 0.2967
Echinococcus multilocularis aurora kinase A 0.0083 0.0101 0.0115
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0083 0.0101 0.0116
Loa Loa (eye worm) TK protein kinase 0.0062 0.0061 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Schistosoma mansoni protein kinase 0.0062 0.0061 0.0056
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Trypanosoma cruzi hypothetical protein 0.0079 0.0092 0.4387
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0062 0.0061 0.0067
Onchocerca volvulus 0.0079 0.0092 0.0484
Echinococcus granulosus activated cdc42 kinase 1 0.0062 0.0061 0.0067
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0024 0.0021
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Loa Loa (eye worm) TK/ABL protein kinase 0.0062 0.0061 0.0057
Trypanosoma brucei aurora B kinase 0.0083 0.0101 0.5533
Loa Loa (eye worm) hypothetical protein 0.0987 0.1819 0.1816
Echinococcus multilocularis roundabout 2 0.012 0.0171 0.0199
Echinococcus granulosus receptor type guanylyl cyclase 0.0062 0.0061 0.0067
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Echinococcus multilocularis tyrosine protein kinase csk 0.0062 0.0061 0.0067
Schistosoma mansoni hypothetical protein 0.035 0.0609 0.0604
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.01 0.0133 1
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0079 0.0092 0.0105
Brugia malayi Protein kinase domain containing protein 0.0333 0.0577 0.0577
Echinococcus multilocularis natriuretic peptide receptor 1 0.0062 0.0061 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Schistosoma mansoni bromodomain containing protein 0.0076 0.0088 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0061 0.0056
Brugia malayi Plexin repeat family protein 0.0987 0.1819 0.1819
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Echinococcus multilocularis tyrosine protein kinase 0.0062 0.0061 0.0067
Schistosoma mansoni fibrocystin l 0.0183 0.0291 0.0287
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Echinococcus multilocularis protein tyrosine kinase 0.0062 0.0061 0.0067
Trichomonas vaginalis STE family protein kinase 0.0062 0.0061 0.027
Trypanosoma cruzi PH domain containing protein, putative 0.0079 0.0092 0.4387
Trichomonas vaginalis kinesin light chain, putative 0.0079 0.0092 0.0472
Trichomonas vaginalis TK family protein kinase 0.0062 0.0061 0.027
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0052 0.0041 0.0037
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.5289 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0083 0.0101 0.5613
Loa Loa (eye worm) rho-GTPase-activating 0.0079 0.0092 0.0089
Entamoeba histolytica PH domain containing protein kinase, putative 0.01 0.0133 0.0473
Echinococcus multilocularis beta 1 syntrophin 0.0079 0.0092 0.0105
Echinococcus granulosus roundabout 2 0.012 0.0171 0.0199
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0079 0.0092 0.0105
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0062 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.0291 0.1751
Loa Loa (eye worm) TK/CSK protein kinase 0.0062 0.0061 0.0057
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Leishmania major hypothetical protein, conserved 0.0079 0.0092 0.4387
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.01 0.0133 1
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Brugia malayi TAR-binding protein 0.0076 0.0088 0.0088
Brugia malayi Cytohesin 3 0.0079 0.0092 0.0092
Onchocerca volvulus 0.0062 0.0061 0.0311
Onchocerca volvulus 0.0062 0.0061 0.0311
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Loa Loa (eye worm) TK/ROR protein kinase 0.0062 0.0061 0.0057
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0067 0.0071 0.0079
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0208
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0079 0.0092 0.0472
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Echinococcus multilocularis geminin 0.0205 0.0332 0.0391
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0062 0.0061 0.0067
Echinococcus multilocularis actin binding protein anillin 0.0079 0.0092 0.0105
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.01 0.0133 1
Loa Loa (eye worm) Plekhf2 protein 0.0079 0.0092 0.0089
Onchocerca volvulus 0.0038 0.0015 0.0055
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0858 0.1573 0.157
Loa Loa (eye worm) hypothetical protein 0.0115 0.0161 0.0157
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Loa Loa (eye worm) hypothetical protein 0.0418 0.0738 0.0735
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.0061 0.0061
Echinococcus granulosus fibroblast growth factor receptor 4 0.0062 0.0061 0.0067
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0062 0.0061 0.0067
Echinococcus granulosus regulator of G protein signaling 3 0.0858 0.1573 0.1876
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0052 0.0057
Trypanosoma cruzi aurora B kinase, putative 0.0083 0.0101 0.5533
Schistosoma mansoni dynamin 0.0079 0.0092 0.0088
Onchocerca volvulus Tyrosine kinase homolog 0.0062 0.0061 0.0311
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0472
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.0061 0.0057
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0062 0.0061 0.0056
Brugia malayi hypothetical protein 0.0286 0.0486 0.0486
Echinococcus multilocularis epidermal growth factor receptor 0.0062 0.0061 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Onchocerca volvulus Putative zinc finger protein 0.0079 0.0092 0.0484
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0001
Plasmodium falciparum calcium-dependent protein kinase 7 0.01 0.0133 1
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0062 0.0061 0.0067
Schistosoma mansoni hypothetical protein 0.0079 0.0092 0.0088
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Echinococcus granulosus natriuretic peptide receptor 1 0.0062 0.0061 0.0067
Schistosoma mansoni protein kinase 0.0062 0.0061 0.0056
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0062 0.0061 0.0067
Onchocerca volvulus 0.0033 0.0005 0.0001
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0082 0.0093
Schistosoma mansoni regulator of G protein signaling 0.0858 0.1573 0.157
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0079 0.0092 0.4387
Echinococcus granulosus oxysterol binding protein 1 0.0079 0.0092 0.0105
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Onchocerca volvulus 0.0079 0.0092 0.0484
Trypanosoma cruzi hypothetical protein 0.0079 0.0092 0.4387
Loa Loa (eye worm) RGC/RGC protein kinase 0.0062 0.0061 0.0057
Echinococcus granulosus Pleckstrin y 0.0079 0.0092 0.0105
Trypanosoma cruzi PH domain containing protein, putative 0.0079 0.0092 0.4387
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0062 0.0061 0.0067
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0101 0.0525
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1805 0.2152
Trypanosoma cruzi serine/threonine protein kinase, putative 0.01 0.0133 1
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Loa Loa (eye worm) TK protein kinase 0.0062 0.0061 0.0057
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.4054 0.7652 0.7651
Echinococcus granulosus tyrosine protein kinase shark 0.0062 0.0061 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Echinococcus multilocularis protein patched 0.0051 0.004 0.0042
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0088 0.0085
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0092
Echinococcus multilocularis Pleckstrin y 0.0079 0.0092 0.0105
Loa Loa (eye worm) hypothetical protein 0.0858 0.1573 0.157
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Brugia malayi RNA binding protein 0.0076 0.0088 0.0088
Toxoplasma gondii Oxysterol-binding protein 0.0079 0.0092 0.4387
Schistosoma mansoni protein kinase 0.0062 0.0061 0.0056
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0092
Echinococcus multilocularis myotubularin protein 13 0.0079 0.0092 0.0105
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0183 0.0291 0.1751
Loa Loa (eye worm) TK protein kinase 0.0062 0.0061 0.0057
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0079 0.0092 0.0089
Schistosoma mansoni vesicular amine transporter 0.0117 0.0166 0.0162
Echinococcus granulosus tyrosine protein kinase pr2 0.0062 0.0061 0.0067
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0101 0.0525
Schistosoma mansoni cell adhesion molecule 0.012 0.0171 0.0166
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.01 0.0133 1
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0208
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0083 0.0101 0.0262
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0089
Trichomonas vaginalis AGC family protein kinase 0.01 0.0133 0.0731
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0092
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0062 0.0061 0.0067
Loa Loa (eye worm) TK/ALK protein kinase 0.0333 0.0577 0.0573
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0061 0.0056
Entamoeba histolytica hypothetical protein 0.0079 0.0092 0.0208
Loa Loa (eye worm) TK/RYK protein kinase 0.0062 0.0061 0.0057
Brugia malayi serine/threonine kinase 12 0.0083 0.0101 0.0101
Loa Loa (eye worm) AGC/AKT protein kinase 0.01 0.0133 0.0129
Brugia malayi protein-tyrosine kinase 0.0062 0.0061 0.0061
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0079 0.0092 0.0105
Trypanosoma cruzi PH domain containing protein, putative 0.0079 0.0092 0.4387
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0088 0.0088
Echinococcus granulosus Regulator of G protein signaling 20 0.0858 0.1573 0.1876
Brugia malayi hypothetical protein 0.0858 0.1573 0.1573
Echinococcus granulosus semaphorin 1A 0.0418 0.0738 0.0877
Echinococcus multilocularis protein KINase family member (kin 25) 0.0062 0.0061 0.0067
Brugia malayi Protein kinase domain containing protein 0.0062 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0005 0.0001
Echinococcus granulosus Pleckstrin y 0.0079 0.0092 0.0105
Echinococcus multilocularis activated cdc42 kinase 1 0.0062 0.0061 0.0067
Echinococcus multilocularis muscleblind protein 1 0.018 0.0286 0.0336
Loa Loa (eye worm) hypothetical protein 0.0115 0.0161 0.0157
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Brugia malayi ephrin receptor 1 precursor 0.0062 0.0061 0.0061
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0067 0.0075
Entamoeba histolytica protein kinase, putative 0.0083 0.0101 0.0262
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0032 0.0027
Echinococcus granulosus retinal guanylyl cyclase 2 0.0062 0.0061 0.0067
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Schistosoma mansoni tyrosine kinase 0.0062 0.0061 0.0056
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0062 0.0061 0.0056
Loa Loa (eye worm) hypothetical protein 0.0046 0.0031 0.0027
Echinococcus multilocularis DCC interacting protein 13 beta 0.0079 0.0092 0.0105
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0088 0.0085
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.01 0.0133 0.0731
Loa Loa (eye worm) AUR protein kinase 0.0083 0.0101 0.0097
Entamoeba histolytica p21-activated kinase 0.01 0.0133 0.0473
Trichomonas vaginalis TKL family protein kinase 0.0062 0.0061 0.027
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0062 0.0061 0.0067
Echinococcus granulosus tar DNA binding protein 0.0076 0.0088 0.01
Schistosoma mansoni goodpasture antigen-binding protein 0.0079 0.0092 0.0088
Trypanosoma cruzi PH domain containing protein, putative 0.0079 0.0092 0.4387
Plasmodium falciparum protein kinase, putative 0.0083 0.0101 0.5613
Brugia malayi TBC domain containing protein 0.0079 0.0092 0.0092
Loa Loa (eye worm) RNA binding protein 0.0076 0.0088 0.0085
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.008 0.009
Echinococcus granulosus aurora kinase A 0.0083 0.0101 0.0115
Trichomonas vaginalis alpha chimerin, putative 0.0079 0.0092 0.0472
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0001
Entamoeba histolytica hypothetical protein, conserved 0.0079 0.0092 0.0208
Brugia malayi Tyrosine-protein kinase PR2 0.0062 0.0061 0.0061
Onchocerca volvulus 0.0062 0.0061 0.0311

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 41.262 uM PUBCHEM_BIOASSAY: Discovery of Small Molecule Probes for H1N1 Influenza NS1A. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504399] ChEMBL. No reference
Potency (functional) 0.4467 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.0995 uM PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 7.9433 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 10.3183 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23
Giardia lamblia

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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