Detailed information for compound 1728077

Basic information

Technical information
  • TDR Targets ID: 1728077
  • Name: (2S,3R,4S,5S,6R)-2-[[4-[(4-aminophenyl)methyl ]-5-propan-2-yl-1H-pyrazol-3-yl]oxy]-6-(hydro xymethyl)oxane-3,4,5-triol
  • MW: 393.434 | Formula: C19H27N3O6
  • H donors: 6 H acceptors: 5 LogP: 0.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]1O[C@@H](Oc2n[nH]c(c2Cc2ccc(cc2)N)C(C)C)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C19H27N3O6/c1-9(2)14-12(7-10-3-5-11(20)6-4-10)18(22-21-14)28-19-17(26)16(25)15(24)13(8-23)27-19/h3-6,9,13,15-17,19,23-26H,7-8,20H2,1-2H3,(H,21,22)/t13-,15-,16+,17-,19+/m1/s1
  • InChiKey: AEMRFZNVDRRUMY-YRHQEJDOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,3R,4S,5S,6R)-2-[[4-[(4-aminophenyl)methyl]-5-isopropyl-1H-pyrazol-3-yl]oxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
  • (2S,3R,4S,5S,6R)-2-[[4-(4-aminobenzyl)-5-isopropyl-1H-pyrazol-3-yl]oxy]-6-methylol-tetrahydropyran-3,4,5-triol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 5 (sodium/glucose cotransporter), member 1 Starlite/ChEMBL References
Homo sapiens solute carrier family 5 (sodium/glucose cotransporter), member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus solute carrier family 5 Get druggable targets OG5_127197 All targets in OG5_127197
Echinococcus multilocularis sodium:myo inositol cotransporter Get druggable targets OG5_127197 All targets in OG5_127197
Echinococcus granulosus sodium:glucose cotransporter 2 Get druggable targets OG5_127197 All targets in OG5_127197
Echinococcus granulosus sodium:glucose cotransporter Get druggable targets OG5_127197 All targets in OG5_127197
Echinococcus multilocularis sodium:glucose cotransporter 2 Get druggable targets OG5_127197 All targets in OG5_127197
Schistosoma mansoni inositol transporter Get druggable targets OG5_127197 All targets in OG5_127197
Schistosoma japonicum expressed protein Get druggable targets OG5_127197 All targets in OG5_127197
Schistosoma mansoni inositol transporter Get druggable targets OG5_127197 All targets in OG5_127197
Schistosoma japonicum ko:K03307 solute:Na+ symporter, SSS family, putative Get druggable targets OG5_127197 All targets in OG5_127197
Echinococcus granulosus sodium:myo inositol cotransporter Get druggable targets OG5_127197 All targets in OG5_127197
Echinococcus multilocularis solute carrier family 5 Get druggable targets OG5_127197 All targets in OG5_127197
Schistosoma japonicum Sodium/myo-inositol cotransporter, putative Get druggable targets OG5_127197 All targets in OG5_127197
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0028 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.003 0.0027 0.1244
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0052 0.0076 0.0084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.01 0.011
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0015 0.0129
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0052 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0007 0.0007
Brugia malayi neuropeptide F receptor 0.0063 0.01 0.01
Brugia malayi metabotropic glutamate receptor type 2 0.0019 0.0005 0.0005
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0019 0.0005 0.0005
Trichomonas vaginalis inositol monophosphatase, putative 0.0113 0.0211 0.1937
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.003 0.0027 0.1244
Loa Loa (eye worm) RGC/RGC protein kinase 0.0019 0.0005 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0042 0.0379
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0031 0.226
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0003 0.0002
Brugia malayi follicle stimulating hormone receptor 0.0547 0.117 0.117
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0008 0.0008
Echinococcus granulosus nAChR subunit 0.0028 0.0024 0.0026
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0216 0.0216
Loa Loa (eye worm) RGC/RGC protein kinase 0.0019 0.0005 0.0005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0076 0.0076
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0034 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.003 0.0027 0.0568
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0031 0.2265
Brugia malayi GnHR receptor homolog 0.0063 0.01 0.01
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0077 0.0133 0.0147
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0063 0.01 0.01
Brugia malayi G-protein coupled receptor 0.0063 0.01 0.01
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0077 0.0133 0.0147
Brugia malayi hypothetical protein 0.0063 0.01 0.01
Schistosoma mansoni DNA helicase recq5 0.0018 0.0003 0.0002
Echinococcus granulosus lamin dm0 0.0028 0.0023 0.0025
Echinococcus granulosus glutamate receptor 2 0.0114 0.0214 0.0237
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0177 0.0353 0.0392
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0073 0.0073
Loa Loa (eye worm) serotonin transporter b 0.0455 0.0968 0.0968
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.1088 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.01 0.011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Onchocerca volvulus 0.01 0.0182 0.0197
Schistosoma mansoni nAChR subunit 0.0052 0.0076 0.0084
Echinococcus granulosus receptor type guanylyl cyclase 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Onchocerca volvulus 0.0077 0.0133 0.0142
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0073 0.5498
Echinococcus multilocularis lamin dm0 0.0028 0.0023 0.0025
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0034 0.0037
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.003 0.0027 0.1244
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0077 0.0133 0.0147
Echinococcus granulosus sex peptide receptor 0.0063 0.01 0.011
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.003 0.0027 0.1244
Schistosoma mansoni hypothetical protein 0.01 0.0182 0.0201
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Toxoplasma gondii exonuclease III APE 0.0077 0.0133 0.6288
Echinococcus granulosus tar DNA binding protein 0.0065 0.0105 0.0116
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0455 0.0968 0.0968
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.003 0.0027 0.0027
Echinococcus multilocularis neuropeptide receptor A26 0.0063 0.01 0.011
Schistosoma mansoni amine GPCR 0.0063 0.01 0.011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0455 0.0968 0.0968
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0007 0.0006
Onchocerca volvulus 0.0036 0.0042 0.0041
Onchocerca volvulus 0.0093 0.0167 0.018
Brugia malayi Melatonin receptor type 1A 0.0063 0.01 0.01
Echinococcus granulosus somatostatin receptor 0.0063 0.01 0.011
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.0216 0.8673
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.01 0.011
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0023
Brugia malayi hypothetical protein 0.0024 0.0015 0.0015
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.0216 0.4575
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0077 0.0133 0.0132
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0023
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0052 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Brugia malayi hypothetical protein 0.0063 0.01 0.01
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0116 0.5276
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0007 0.0006
Onchocerca volvulus 0.0063 0.01 0.0106
Loa Loa (eye worm) melatonin receptor type 1A 0.0063 0.01 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0334 0.0701 0.6439
Treponema pallidum sodium- and chloride- dependent transporter 0.0455 0.0968 1
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0063 0.0101 0.0112
Loa Loa (eye worm) hypothetical protein 0.0125 0.0239 0.0238
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0024 0.0015 0.0016
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0007 0.0006
Onchocerca volvulus 0.0063 0.01 0.0106
Brugia malayi beta-lactamase 0.0036 0.0042 0.0042
Onchocerca volvulus 0.0052 0.0076 0.0079
Brugia malayi putative neuropeptide receptor NPR1 0.0063 0.01 0.01
Echinococcus granulosus biogenic amine 5HT receptor 0.0063 0.01 0.011
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0069 0.0076
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0063 0.01 0.011
Brugia malayi hypothetical protein 0.0169 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Echinococcus multilocularis allatostatin A receptor 0.0063 0.01 0.011
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0063 0.01 0.011
Echinococcus multilocularis receptor type guanylyl cyclase 0.0019 0.0005 0.0005
Schistosoma mansoni opsin-like receptor 0.0063 0.01 0.011
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0113 0.0211 0.9787
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0019 0.0005 0.0005
Plasmodium falciparum transporter, putative 0.0077 0.0133 0.9981
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.1088 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0023
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0023 0.0023
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0052 0.0076 0.0084
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0073 0.0073
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0031 0.226
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0007 0.0007
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0093 0.0167 0.0184
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0077 0.0133 0.0132
Echinococcus multilocularis geminin 0.1042 0.2263 0.2513
Loa Loa (eye worm) hypothetical protein 0.0033 0.0036 0.0035
Schistosoma mansoni lipoxygenase 0.0125 0.0237 0.0263
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0101 0.0185 0.7264
Trypanosoma brucei trypanothione reductase 0.005 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0125 0.0237 0.0263
Schistosoma mansoni hypothetical protein 0.003 0.0027 0.003
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0003 0.0155
Echinococcus multilocularis somatostatin receptor 0.0063 0.01 0.011
Echinococcus granulosus sodium and chloride dependent glycine 0.0077 0.0133 0.0147
Schistosoma mansoni lamin 0.0028 0.0023 0.0025
Echinococcus granulosus neuropeptide receptor 0.0063 0.01 0.011
Echinococcus granulosus neuropeptide receptor 0.0063 0.01 0.011
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0015 0.0014
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0015 0.0014
Loa Loa (eye worm) TYRA-2 protein 0.0063 0.01 0.01
Brugia malayi PAS domain containing protein 0.005 0.0074 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.01 0.011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0034 0.0034
Echinococcus granulosus g-protein coupled receptor 0.0063 0.01 0.011
Echinococcus granulosus allatostatin A receptor 0.0063 0.01 0.011
Echinococcus granulosus sodium and chloride dependent glycine 0.0077 0.0133 0.0147
Schistosoma mansoni glutamate receptor NMDA 0.0258 0.0531 0.0589
Onchocerca volvulus 0.0021 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Onchocerca volvulus 0.0028 0.0023 0.002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0076 0.0076
Trypanosoma cruzi cytochrome p450-like protein, putative 0.003 0.0027 0.0027
Brugia malayi larval opioid receptor 0.0063 0.01 0.01
Echinococcus multilocularis glutamate receptor NMDA 0.0081 0.014 0.0155
Schistosoma mansoni inositol transporter 0.0363 0.0763 0.0847
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.0216 0.4575
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0052 0.0076 0.0076
Echinococcus granulosus metabotropic glutamate receptor 5 0.0019 0.0005 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0042 0.0046
Leishmania major lanosterol 14-alpha-demethylase, putative 0.003 0.0027 0.0027
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0023 0.0023
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0069 0.0076
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.003 0.0027 0.0568
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0008 0.0008
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0216 0.0216
Onchocerca volvulus 0.0063 0.01 0.0106
Echinococcus granulosus dna polymerase kappa 0.002 0.0007 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.003 0.0027 0.0568
Echinococcus multilocularis fmrfamide receptor 0.0063 0.01 0.011
Schistosoma mansoni sodium/solute symporter 0.0093 0.0167 0.0184
Schistosoma mansoni hypothetical protein 0.1042 0.2263 0.2513
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0031 0.0275
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0042 0.0041
Schistosoma mansoni hypothetical protein 0.0063 0.0101 0.0112
Echinococcus granulosus tyrosine kinase 0.0019 0.0005 0.0005
Brugia malayi Dopamine receptor 0.0063 0.01 0.01
Schistosoma mansoni tyrosine kinase 0.0019 0.0005 0.0005
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0003
Onchocerca volvulus 0.0024 0.0015 0.0011
Schistosoma mansoni glutamate receptor kainate 0.0158 0.0311 0.0344
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0063 0.01 0.011
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0063 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Echinococcus multilocularis glycine receptor subunit beta 0.0052 0.0076 0.0084
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0077 0.0133 0.0147
Brugia malayi Abnormal catecholamine distribution protein 1 0.0381 0.0804 0.0804
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0052 0.0076 0.0084
Schistosoma mansoni vesicular acetylcholine transporter 0.4095 0.9005 1
Brugia malayi hypothetical protein 0.0063 0.01 0.01
Loa Loa (eye worm) GABA receptor subunit 0.0028 0.0024 0.0023
Toxoplasma gondii hypothetical protein 0.0077 0.0133 0.6276
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0052 0.0076 0.0076
Onchocerca volvulus 0.0037 0.0045 0.0044
Loa Loa (eye worm) CYP4Cod1 0.0039 0.0048 0.0048
Echinococcus multilocularis G-protein coupled receptor, putative 0.0063 0.01 0.011
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.0216 0.4565
Echinococcus multilocularis g protein coupled receptor 0.0063 0.01 0.011
Loa Loa (eye worm) solute carrier family 6 member 4 0.0455 0.0968 0.0968
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0063 0.01 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.1088 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0008 0.0008
Echinococcus granulosus intermediate filament protein 0.0028 0.0023 0.0025
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0076 0.0076
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0024 0.0015 0.0015
Schistosoma mansoni neuropeptide F-like receptor 0.0063 0.01 0.011
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.003 0.0027 0.0568
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0052 0.0076 0.0084
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0063 0.01 0.01
Onchocerca volvulus Neuropeptide F receptor homolog 0.0063 0.01 0.0106
Echinococcus multilocularis sodium and chloride dependent glycine 0.0077 0.0133 0.0147
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0455 0.0968 0.0968
Brugia malayi Cytochrome P450 family protein 0.003 0.0027 0.0027
Brugia malayi intermediate filament protein 0.0028 0.0023 0.0023
Brugia malayi RNA binding protein 0.0065 0.0105 0.0105
Echinococcus granulosus solute carrier family 5 0.0363 0.0763 0.0847
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0021 0.1527
Plasmodium vivax glutathione reductase, putative 0.005 0.0073 0.5498
Loa Loa (eye worm) hypothetical protein 0.007 0.0117 0.0117
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0074 0.0081
Echinococcus multilocularis solute carrier family 5 0.0363 0.0763 0.0847
Schistosoma mansoni single-minded 0.005 0.0074 0.0081
Toxoplasma gondii hypothetical protein 0.0077 0.0133 0.6276
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0049 0.3619
Brugia malayi G-protein coupled receptor 0.0063 0.01 0.01
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0019 0.0004 0.0037
Echinococcus granulosus atrial natriuretic peptide receptor 0.0019 0.0005 0.0005
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0031 0.226
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Onchocerca volvulus Putative nachr subunit 0.0052 0.0076 0.0079
Onchocerca volvulus 0.0036 0.0042 0.0041
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0077 0.0133 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Schistosoma mansoni biogenic amine (5HT) receptor 0.0063 0.01 0.011
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0073 0.1545
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0052 0.0076 0.0084
Echinococcus multilocularis bloom syndrome protein 0.0045 0.006 0.0066
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0077 0.0133 0.0133
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0177 0.0353 0.0392
Loa Loa (eye worm) hypothetical protein 0.0102 0.0188 0.0188
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0052 0.0076 0.0084
Schistosoma mansoni nAChR subunit 0.0052 0.0076 0.0084
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0077 0.0133 0.0133
Onchocerca volvulus 0.0063 0.01 0.0106
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.01 0.011
Onchocerca volvulus 0.0125 0.0239 0.026
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.003 0.0027 0.1244
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0063 0.01 0.01
Brugia malayi cytochrome P450 0.003 0.0027 0.0027
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0011 0.0011
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0052 0.0076 0.0076
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0048 0.0048
Echinococcus granulosus zinc finger protein 0.0019 0.0004 0.0004
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0063 0.0101 0.0112
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0077 0.0133 0.0147
Mycobacterium ulcerans beta-lactamase 0.0036 0.0042 0.1914
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0031 0.0309
Echinococcus multilocularis neuropeptide FF receptor 2 0.0063 0.01 0.011
Onchocerca volvulus 0.0052 0.0076 0.0079
Brugia malayi Dopamine receptor protein 2 0.0063 0.01 0.01
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0052 0.0076 0.0084
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0031 0.0275
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.003 0.0027 0.1244
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0003 0.0155
Brugia malayi exodeoxyribonuclease III family protein 0.0077 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Schistosoma mansoni nAChR subunit 0.0052 0.0076 0.0084
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0052 0.0076 0.0076
Onchocerca volvulus 0.0125 0.0239 0.026
Brugia malayi GH02984p 0.0093 0.0167 0.0167
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0003 0.0002
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0063 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0077 0.0133 0.0133
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0125 0.0239 0.0264
Loa Loa (eye worm) hypothetical protein 0.004 0.005 0.005
Brugia malayi Serotonin receptor 0.0063 0.01 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0352 0.074 0.6805
Schistosoma mansoni rab6-interacting 0.0021 0.0008 0.0008
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0077 0.0133 0.0147
Schistosoma mansoni polycystin 1-related 0.0021 0.0008 0.0008
Leishmania major DNA polymerase eta, putative 0.002 0.0007 0.0006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0076 0.0076
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0021 0.096
Schistosoma mansoni neuropeptide receptor 0.0063 0.01 0.011
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0077 0.0133 0.0133
Onchocerca volvulus Glucosylceramidase homolog 0.0334 0.0701 0.0773
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0125 0.0239 0.0264
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0015 0.0015
Echinococcus multilocularis GPCR, family 2 0.0032 0.0034 0.0037
Brugia malayi hypothetical protein 0.0063 0.01 0.01
Echinococcus multilocularis glutamate receptor 2 0.0158 0.0311 0.0344
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0125 0.0237 0.0263
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0052 0.0076 0.0076
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0031 0.2265
Trichomonas vaginalis ap endonuclease, putative 0.0077 0.0133 0.1218
Onchocerca volvulus 0.0455 0.0968 0.107
Plasmodium falciparum thioredoxin reductase 0.005 0.0073 0.5498
Echinococcus granulosus cytochrome P450 2K1 0.003 0.0027 0.003
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0042 0.0046
Mycobacterium leprae Probable lipase LipE 0.0036 0.0042 0.0664
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0116 0.0128
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.0244 0.5177
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0007 0.0284
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0037
Echinococcus multilocularis glutamate receptor 2 0.0114 0.0214 0.0237
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0019 0.0004 0.0271
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0077 0.0133 0.0147
Plasmodium vivax SET domain protein, putative 0.0032 0.0032 0.2396
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0077 0.0133 0.0147
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Schistosoma mansoni opsin-like receptor 0.0063 0.01 0.011
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0077 0.0133 0.6276
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0063 0.01 0.011
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0042 0.0379
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Loa Loa (eye worm) G-protein coupled receptor 0.0063 0.01 0.01
Schistosoma mansoni neuropeptide F-like receptor 0.0063 0.01 0.011
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0008 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0105 0.0116
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0052 0.0076 0.0076
Schistosoma mansoni metabotropic glutamate receptor 0.0019 0.0005 0.0005
Brugia malayi Glutamate receptor 1 precursor 0.0158 0.0311 0.0311
Echinococcus multilocularis neuropeptide Y receptor 0.0063 0.01 0.011
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0327 0.0684 0.0759
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0024 0.0015 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0007 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0007 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.01 0.011
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.0244 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0031 0.0275
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Echinococcus granulosus dro:myosuppressin receptor 0.0063 0.01 0.011
Chlamydia trachomatis glutamine binding protein 0.0019 0.0004 0.0271
Schistosoma mansoni lamin 0.0028 0.0023 0.0025
Echinococcus granulosus glycine receptor subunit alpha 1 0.0052 0.0076 0.0084
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0063 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0023
Loa Loa (eye worm) inositol-1 0.0113 0.0211 0.0211
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0003 0.0002
Schistosoma mansoni biogenic amine receptor 0.0063 0.01 0.011
Schistosoma mansoni biogenic amine receptor 0.0063 0.01 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0007 0.0006
Echinococcus granulosus glycine receptor subunit alpha 1 0.0052 0.0076 0.0084
Leishmania major cytochrome p450-like protein 0.003 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0931 0.2018 0.2017
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0077 0.0133 0.0133
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0216 0.1978
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0063 0.01 0.011
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0116 0.0116
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.003 0.0027 0.1244
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0055 0.006
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0177 0.0353 0.0392
Echinococcus multilocularis 0.003 0.0027 0.003
Schistosoma mansoni glutamate receptor kainate 0.0158 0.0311 0.0344
Echinococcus multilocularis sodium and chloride dependent glycine 0.0077 0.0133 0.0147
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0024 0.0015 0.0015
Brugia malayi neuropeptide F receptor 0.0063 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0105 0.0116
Schistosoma mansoni hypothetical protein 0.0063 0.01 0.011
Echinococcus multilocularis serotonin receptor 0.0063 0.01 0.011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0113 0.0211 0.0211
Brugia malayi Dopamine receptor protein 1 0.0063 0.01 0.01
Brugia malayi phosphofructokinase 0.0115 0.0216 0.0216
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0042 0.1914
Brugia malayi Receptor family ligand binding region containing protein 0.0019 0.0005 0.0005
Schistosoma mansoni DNA helicase recq1 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0488 0.104 0.104
Leishmania major hypothetical protein, conserved 0.0036 0.0042 0.0041
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0007 0.0006
Schistosoma mansoni protein kinase 0.0019 0.0005 0.0005
Schistosoma mansoni acetylcholine receptor-related 0.0024 0.0015 0.0016
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0039 0.0048 0.2195
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.1088 1
Trichomonas vaginalis ap endonuclease, putative 0.0077 0.0133 0.1218
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0039 0.0043
Brugia malayi glutathione reductase 0.005 0.0073 0.0073
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0042 0.0874
Schistosoma mansoni hypothetical protein 0.1042 0.2263 0.2513
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0052 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Mycobacterium ulcerans lipase LipD 0.0036 0.0042 0.1914
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0082 0.0144 0.0159
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Schistosoma mansoni metabotropic glutamate receptor 0.0019 0.0005 0.0005
Loa Loa (eye worm) neuropeptide F receptor 0.0063 0.01 0.01
Onchocerca volvulus 0.0253 0.052 0.0573
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Plasmodium falciparum amino acid transporter, putative 0.0077 0.0133 0.9981
Schistosoma mansoni neurotransmitter gated ion channel 0.0028 0.0024 0.0026
Schistosoma mansoni nAChR subunit 0.0024 0.0015 0.0016
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0028 0.0024 0.0026
Echinococcus granulosus peptide allatostatin:somatostatin 0.0063 0.01 0.011
Schistosoma mansoni glutamate receptor AMPA 0.0158 0.0311 0.0344
Brugia malayi Doublecortin family protein 0.0021 0.0008 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.01 0.011
Schistosoma mansoni amine GPCR 0.0063 0.01 0.011
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.0244 0.5177
Schistosoma mansoni hypothetical protein 0.007 0.0117 0.0129
Mycobacterium tuberculosis Conserved protein 0.0036 0.0042 0.0874
Onchocerca volvulus 0.0077 0.0133 0.0142
Loa Loa (eye worm) hypothetical protein 0.0042 0.0054 0.0054
Echinococcus granulosus neuropeptides capa receptor 0.0063 0.01 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0007 0.0006
Brugia malayi ORL1-like opioid receptor 0.0063 0.01 0.01
Echinococcus granulosus glutamate receptor subunit protein glur 0.0063 0.0101 0.0112
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0216 0.0215
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Brugia malayi Guanylyl cyclase protein 23 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0034 0.0037
Schistosoma mansoni cytochrome P450 0.003 0.0027 0.003
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Echinococcus multilocularis fmrfamide receptor 0.0063 0.01 0.011
Brugia malayi Cation transporter family protein 0.0052 0.0076 0.0076
Brugia malayi hypothetical protein 0.0077 0.0133 0.0133
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0015 0.0465
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.01 0.011
Onchocerca volvulus 0.0063 0.01 0.0106
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0077 0.0133 1
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0077 0.0133 0.0147
Echinococcus granulosus glutamate NMDA receptor subunit 0.0327 0.0684 0.0759
Echinococcus granulosus glutamate receptor NMDA 0.0081 0.014 0.0155
Leishmania major DNA polymerase kappa, putative 0.002 0.0007 0.0006
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0048 0.0047
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.003 0.0027 0.0568
Schistosoma mansoni microtubule-associated protein tau 0.143 0.3121 0.3465
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0007 0.0007
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0077 0.0133 0.0133
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0077 0.0133 0.608
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0455 0.0968 0.0968
Plasmodium vivax amine transporter, putative 0.0077 0.0133 0.9981
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0052 0.0076 0.0084
Echinococcus multilocularis dro:myosuppressin receptor 0.0063 0.01 0.011
Leishmania major hypothetical protein, conserved 0.0027 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0023
Schistosoma mansoni DNA polymerase eta 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Echinococcus granulosus inositol monophosphatase 1 0.0113 0.0211 0.0234
Schistosoma mansoni histamine h1 receptor 0.0063 0.01 0.011
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0008 0.0008
Brugia malayi hypothetical protein 0.0021 0.0008 0.0008
Trypanosoma cruzi extracellular receptor, putative 0.0019 0.0005 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0334 0.0701 0.6439
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.01 0.011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.003 0.0027 0.1244
Echinococcus multilocularis g-protein coupled receptor 0.0063 0.01 0.011
Schistosoma mansoni neurotransmitter gated ion channel 0.0024 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Plasmodium falciparum glutathione reductase 0.005 0.0073 0.5498
Brugia malayi Metabotropic glutamate receptor precursor. 0.0019 0.0005 0.0005
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0004 0.0166
Brugia malayi hypothetical protein 0.0024 0.0015 0.0015
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0047 0.0047
Brugia malayi Cytochrome P450 family protein 0.0039 0.0048 0.0048
Schistosoma mansoni glutamate receptor AMPA 0.0158 0.0311 0.0344
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.051 0.1088 0.1088
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Schistosoma mansoni ap endonuclease 0.0077 0.0133 0.0147
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0116 0.0115
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0063 0.01 0.011
Echinococcus granulosus g protein coupled receptor 0.0063 0.01 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.01 0.011
Onchocerca volvulus 0.0063 0.01 0.0106
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.4095 0.9005 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.01 0.011
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0003 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0021 0.002
Brugia malayi Bromodomain containing protein 0.0073 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0077 0.0133 0.0133
Schistosoma mansoni neuropeptide f receptor 76f 0.0063 0.01 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.01 0.011
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0077 0.0133 0.2811
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Echinococcus multilocularis neuropeptide Y receptor 0.0063 0.01 0.011
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0116 0.0115
Schistosoma mansoni opsin-like receptor 0.0063 0.01 0.011
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0077 0.0133 0.0147
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0077 0.0133 0.0133
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0007 0.0284
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0042 0.1914
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.003 0.0027 0.0568
Brugia malayi hypothetical protein 0.0019 0.0005 0.0005
Brugia malayi hypothetical protein 0.0063 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0051 0.0056
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0007 0.0091
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0028 0.0024 0.0026
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0077 0.0133 0.0147
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0077 0.0133 0.0147
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0063 0.0101 0.0112
Brugia malayi vesicular acetylcholine transporter unc-17 0.4095 0.9005 0.9005
Loa Loa (eye worm) glutamate receptor 0.0019 0.0005 0.0005
Trichomonas vaginalis esterase, putative 0.0036 0.0042 0.0379
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.01 0.011
Brugia malayi Pre-SET motif family protein 0.0222 0.0452 0.0452
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.006 0.0551
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0216 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0023
Trichomonas vaginalis set domain proteins, putative 0.0253 0.052 0.4778
Onchocerca volvulus 0.0063 0.01 0.0106
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.003 0.0027 0.0568
Schistosoma mansoni neuropeptide receptor 0.0063 0.01 0.011
Schistosoma mansoni amine GPCR 0.0063 0.01 0.011
Echinococcus granulosus lamin 0.0028 0.0023 0.0025
Onchocerca volvulus 0.0021 0.0008 0.0004
Schistosoma mansoni nAChR subunit 0.0052 0.0076 0.0084
Echinococcus granulosus neuropeptide Y receptor 0.0063 0.01 0.011
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0037
Onchocerca volvulus 0.0077 0.0133 0.0142
Echinococcus granulosus glycine receptor subunit beta 0.0052 0.0076 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0042 0.0041
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0381 0.0804 0.0804
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0027 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.01 0.011
Brugia malayi 6-phosphofructokinase 0.0115 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0077 0.0133 0.0147
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.0472 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0023 0.0025
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0093 0.0167 0.0184
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.004
Schistosoma mansoni glutamate receptor kainate 0.0158 0.0311 0.0344
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0334 0.0701 0.6439
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0052 0.0076 0.0084
Loa Loa (eye worm) RNA binding protein 0.0065 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Brugia malayi Cation transporter family protein 0.0125 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0101 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0063 0.01 0.011
Brugia malayi PHD-finger family protein 0.0024 0.0016 0.0016
Schistosoma mansoni inositol monophosphatase 0.0113 0.0211 0.0234
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0052 0.0076 0.0076
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0042 0.3109
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0003 0.0097
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.003 0.0027 0.0568
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0047 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0032 0.0035
Schistosoma mansoni amine GPCR 0.0063 0.01 0.011
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0027 0.0027
Echinococcus granulosus orexin receptor type 2 0.0063 0.01 0.011
Onchocerca volvulus 0.0063 0.01 0.0106
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0177 0.0353 0.0392
Schistosoma mansoni sodium-dependent amino acid transporter 0.0077 0.0133 0.0147
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0069 0.0114 0.0114
Schistosoma mansoni myosin xvIII 0.0063 0.01 0.011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.01 0.011
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0052 0.0076 0.0084
Onchocerca volvulus 0.0028 0.0023 0.002
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0028 0.0024 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.01 0.011
Mycobacterium ulcerans hypothetical protein 0.0036 0.0042 0.1914
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.1088 1
Echinococcus granulosus dna polymerase eta 0.002 0.0007 0.0007
Echinococcus granulosus G protein coupled receptor 139 0.0063 0.01 0.011
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0031 0.0275
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0034 0.0037
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0052 0.0076 0.0076
Echinococcus granulosus neuropeptide FF receptor 2 0.0063 0.01 0.011
Echinococcus granulosus vesicular acetylcholine transporter 0.4095 0.9005 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0133 0.0133
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0031 0.122
Trichomonas vaginalis glucosylceramidase, putative 0.0334 0.0701 0.6439
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.003 0.0027 0.0568
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0077 0.0133 0.6276
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0042 0.0874
Brugia malayi hypothetical protein 0.0063 0.01 0.01
Schistosoma mansoni vesicular amine transporter 0.0381 0.0804 0.0892
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.01 0.011
Leishmania major cytochrome p450-like protein 0.003 0.0027 0.0027
Schistosoma mansoni biogenic amine (5HT) receptor 0.0063 0.01 0.011
Schistosoma mansoni neurotransmitter gated ion channel 0.0024 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Brugia malayi Cytochrome P450 family protein 0.003 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus alpha 1A adrenergic receptor 0.0063 0.01 0.011
Toxoplasma gondii cytochrome p450 superfamily protein 0.003 0.0027 0.1271
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0216 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0019 0.0005 0.0005
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0113 0.0211 0.0211
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0113 0.0211 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.003 0.0027 0.0568
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0216 0.0215
Brugia malayi excitatory GABA receptor EXP-1A 0.0052 0.0076 0.0076
Onchocerca volvulus 0.0063 0.01 0.0106
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.003 0.0027 0.0568
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0007 0.0056
Echinococcus granulosus sodium:glucose cotransporter 0.0363 0.0763 0.0847
Loa Loa (eye worm) beta-lactamase 0.0036 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0028 0.0024 0.0024
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0113 0.0211 0.0211
Onchocerca volvulus 0.0063 0.01 0.0106
Brugia malayi beta-lactamase family protein 0.0036 0.0042 0.0042
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.0452 0.0452
Brugia malayi hypothetical protein 0.0063 0.01 0.01
Brugia malayi hypothetical protein 0.0024 0.0015 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0042 0.0046
Brugia malayi AKH receptor 0.0063 0.01 0.01
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0007 0.0007
Brugia malayi G protein-coupled receptor F59B2.13 0.0063 0.01 0.01
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0063 0.01 0.011
Echinococcus granulosus tachykinin peptides receptor 99D 0.0063 0.01 0.011
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0063 0.01 0.011
Schistosoma mansoni loxhd1 0.0021 0.0008 0.0008
Schistosoma mansoni ap endonuclease 0.0077 0.0133 0.0147
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0052 0.0076 0.0084
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0024 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0093 0.0167 0.0166
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0007 0.0007
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.003 0.0027 0.1244
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0031 0.226
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0003 0.0003
Onchocerca volvulus 0.0028 0.0024 0.0021
Loa Loa (eye worm) ACC-1 protein 0.0052 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Echinococcus multilocularis vesicular acetylcholine transporter 0.4095 0.9005 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.01 0.011
Brugia malayi hypothetical protein 0.0063 0.01 0.01
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.003 0.0027 0.0568
Loa Loa (eye worm) glutamate receptor 1 0.0158 0.0311 0.031
Echinococcus multilocularis zinc finger protein 0.0019 0.0004 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0352 0.074 0.6805
Schistosoma mansoni amine GPCR 0.0063 0.01 0.011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.003 0.0027 0.1244
Loa Loa (eye worm) hypothetical protein 0.0048 0.0069 0.0069
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0134 0.0148
Echinococcus granulosus transcription factor Dp 1 0.004 0.0051 0.0056
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0021
Brugia malayi hypothetical protein 0.0063 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0011 0.0011
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0063 0.01 0.011
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0031 0.1421
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.0216 0.8694
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0134 0.0148
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Echinococcus multilocularis neuropeptides capa receptor 0.0063 0.01 0.011
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0077 0.0133 0.0147
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0039 0.0043
Schistosoma mansoni adenoreceptor 0.0063 0.01 0.011
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0105 0.0116
Echinococcus granulosus metabotropic glutamate receptor 2 0.0019 0.0005 0.0005
Schistosoma mansoni inositol monophosphatase 0.0113 0.0211 0.0234
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0031 0.1421
Schistosoma mansoni nAChR subunit 0.0052 0.0076 0.0084
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.0216 0.2223
Echinococcus multilocularis neuropeptide s receptor 0.0063 0.01 0.011
Loa Loa (eye worm) hypothetical protein 0.0077 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.003 0.0027 0.1244
Loa Loa (eye worm) hypothetical protein 0.0125 0.0239 0.0238
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.003 0.0027 0.0568
Echinococcus granulosus neuropeptide s receptor 0.0063 0.01 0.011
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0052 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0007 0.0006
Brugia malayi sulfakinin receptor protein 0.0063 0.01 0.01
Echinococcus multilocularis serotonin receptor 0.0063 0.01 0.011
Brugia malayi RE15519p 0.0063 0.01 0.01
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.0216 1
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.01 0.011
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0001 0.0001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0077 0.0133 0.1369
Echinococcus granulosus g protein coupled receptor 0.0063 0.01 0.011
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0101 0.0185 0.3916
Brugia malayi Serotonin receptor 0.0063 0.01 0.01
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0063 0.01 0.011
Onchocerca volvulus 0.0024 0.0015 0.0011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0077 0.0133 0.0133
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0042 0.0874
Echinococcus multilocularis lamin 0.0028 0.0023 0.0025
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0004 0.0076
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0116 0.0115
Schistosoma mansoni hypothetical protein 0.0063 0.01 0.011
Schistosoma mansoni alpha-1 adrenergic receptor 0.0063 0.01 0.011
Echinococcus multilocularis nAChR subunit 0.0028 0.0024 0.0026
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.0216 0.0239
Trichomonas vaginalis glucosylceramidase, putative 0.0334 0.0701 0.6439
Loa Loa (eye worm) glutamate receptor 2 0.0158 0.0311 0.031
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0052 0.0076 0.0084
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0077 0.0133 0.0132
Echinococcus multilocularis RUN 0.0021 0.0008 0.0008
Schistosoma mansoni acetylcholine receptor subunit beta 0.0024 0.0015 0.0016
Leishmania major trypanothione reductase 0.005 0.0073 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0007 0.0006
Schistosoma mansoni neuropeptide receptor 0.0063 0.01 0.011
Loa Loa (eye worm) LGC-31 protein 0.0052 0.0076 0.0076
Onchocerca volvulus 0.0063 0.01 0.0106
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0063 0.01 0.011
Loa Loa (eye worm) hypoxia-induced factor 1 0.0156 0.0307 0.0307
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.0216 0.4575
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0042 0.0379
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0021 0.002
Brugia malayi Inositol-1 0.0113 0.0211 0.0211
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0042 0.0874
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0547 0.117 0.117
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0177 0.0353 0.0392
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0076 0.0076
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0042 0.0874
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0042 0.0874
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0116 0.0128
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0063 0.01 0.01
Brugia malayi Cytochrome P450 family protein 0.0039 0.0048 0.0048
Echinococcus granulosus biogenic amine 5HT receptor 0.0063 0.01 0.011
Onchocerca volvulus 0.0036 0.0042 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.01 0.011
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0177 0.0353 0.0392
Loa Loa (eye worm) RecQ helicase 0.0045 0.006 0.006
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0052 0.0076 0.0084
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0031 0.0275
Onchocerca volvulus 0.0063 0.01 0.0106
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0116 0.0115
Leishmania major cytochrome p450-like protein 0.0039 0.0048 0.0047
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.003 0.0027 0.0568
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0037
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0077 0.0133 0.0147
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.1088 1
Echinococcus granulosus nAChR subunit 0.0052 0.0076 0.0084
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0105 0.0116
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0003 0.0097
Echinococcus multilocularis neuropeptide receptor 0.0063 0.01 0.011
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0077 0.0133 0.0147
Echinococcus multilocularis dna polymerase kappa 0.002 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0334 0.0701 0.6439
Mycobacterium tuberculosis Conserved protein 0.0036 0.0042 0.0874
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0023
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0105 0.0105
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0216 0.1978
Loa Loa (eye worm) neuropeptide F receptor 0.0063 0.01 0.01
Echinococcus multilocularis serotonin transporter 0.0455 0.0968 0.1074
Schistosoma mansoni zinc finger protein 0.0019 0.0004 0.0004
Brugia malayi hypoxia-induced factor 1 0.0156 0.0307 0.0307
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0045 0.0049
Loa Loa (eye worm) hypothetical protein 0.2323 0.5093 0.5092
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0063 0.01 0.011
Schistosoma mansoni ATP-binding cassette transporter 0.0158 0.0311 0.0344
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0031 0.0275
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.003 0.0027 0.1244
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0063 0.01 0.011
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0105 0.0116
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0105 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0105 0.0116
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0052 0.0076 0.0084
Schistosoma mansoni sodium/chloride dependent transporter 0.0077 0.0133 0.0147
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0031 0.0275
Echinococcus granulosus GPCR family 2 0.0032 0.0034 0.0037
Schistosoma mansoni bromodomain containing protein 0.0062 0.0098 0.0109
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0052 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Toxoplasma gondii ABC1 family protein 0.0036 0.0042 0.1955
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0052 0.0076 0.0084
Loa Loa (eye worm) hypothetical protein 0.0077 0.0133 0.0133
Onchocerca volvulus 0.0063 0.01 0.0106
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0063 0.01 0.011
Loa Loa (eye worm) cytochrome P450 0.003 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Schistosoma mansoni survival motor neuron protein 0.01 0.0182 0.0201
Leishmania major protein kinase, putative 0.0018 0.0002 0.0002
Echinococcus granulosus serotonin receptor 0.0063 0.01 0.011
Echinococcus multilocularis NMDA receptor 0.0063 0.0101 0.0112
Onchocerca volvulus 0.0032 0.0032 0.0031
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.003 0.0027 0.1244
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0034 0.0034
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0042 0.0874
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0063 0.01 0.011
Loa Loa (eye worm) acetylcholine receptor protein 0.0024 0.0015 0.0015
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0042 0.0046
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0063 0.01 0.011
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0063 0.01 0.011
Loa Loa (eye worm) hypothetical protein 0.0077 0.0133 0.0133
Brugia malayi hypothetical protein 0.0021 0.0008 0.0008
Echinococcus multilocularis dna polymerase eta 0.002 0.0007 0.0007
Onchocerca volvulus 0.0125 0.0239 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.01 0.011
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0019 0.0004 0.0037
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0216 0.0216
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0063 0.01 0.011
Echinococcus granulosus geminin 0.1042 0.2263 0.2513
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0063 0.0101 0.0112
Onchocerca volvulus 0.0024 0.0015 0.0011
Brugia malayi Tachykinin-like peptides receptor 99D 0.0063 0.01 0.01
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.006 0.006
Entamoeba histolytica hypothetical protein 0.0028 0.0024 0.089
Echinococcus granulosus glutamate receptor 2 0.0177 0.0353 0.0392
Loa Loa (eye worm) hypothetical protein 0.0037 0.0045 0.0045
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0076 0.0076
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0007 0.0006
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0024 0.0015 0.0015
Schistosoma mansoni nAChR subunit 0.0052 0.0076 0.0084
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0041 0.0373
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0007 0.0056
Echinococcus multilocularis survival motor neuron protein 1 0.0488 0.104 0.1155
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0007 0.0006
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0028 0.1292
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0077 0.0133 0.6276
Loa Loa (eye worm) hypothetical protein 0.0169 0.0336 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Schistosoma mansoni nAChR subunit 0.0052 0.0076 0.0084
Onchocerca volvulus 0.0063 0.01 0.0106
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0063 0.01 0.011
Schistosoma mansoni glutamate receptor NMDA 0.0327 0.0684 0.0759
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0008 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0042 0.0041
Brugia malayi hypothetical protein 0.0063 0.01 0.01
Echinococcus multilocularis G protein coupled receptor 139 0.0063 0.01 0.011
Echinococcus granulosus hypothetical protein 0.0063 0.01 0.011
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0007 0.013
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0216 0.0239
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.01 0.011
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0003 0.0002
Echinococcus granulosus glycine receptor subunit beta 0.0052 0.0076 0.0084
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0113 0.0211 0.9791
Onchocerca volvulus 0.0028 0.0024 0.0021
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0021 0.1527
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0007 0.0006
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0031 0.1421
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0063 0.01 0.011
Echinococcus granulosus glycine receptor subunit alpha 1 0.0052 0.0076 0.0084
Schistosoma mansoni hypothetical protein 0.0063 0.01 0.011
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0177 0.0353 0.0392
Echinococcus multilocularis nAChR subunit 0.0052 0.0076 0.0084
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0042 0.0042
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.01 0.011
Brugia malayi hypothetical protein 0.0488 0.104 0.104
Brugia malayi Glutamate receptor 2 precursor 0.0158 0.0311 0.0311
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0047 0.0047
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0019 0.0005 0.0005
Giardia lamblia DINP protein human, muc B family 0.002 0.0007 0.0462
Trichomonas vaginalis glucosylceramidase, putative 0.0334 0.0701 0.6439
Toxoplasma gondii thioredoxin reductase 0.005 0.0073 0.3457
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.4095 0.9005 0.9005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.01 0.011
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.0216 0.4575
Echinococcus multilocularis musashi 0.0028 0.0023 0.0025
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0063 0.01 0.011
Onchocerca volvulus 0.0063 0.01 0.0106
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.003 0.0027 0.1244
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0015 0.0015
Brugia malayi 6-phosphofructokinase 0.0115 0.0216 0.0216
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.003 0.0027 0.0568
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0077 0.0133 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.01 0.011
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Echinococcus granulosus g protein coupled receptor 0.0063 0.01 0.011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0008
Onchocerca volvulus 0.0063 0.01 0.0106
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.01 0.011
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0063 0.0101 0.0112
Schistosoma mansoni hypothetical protein 0.0021 0.0008 0.0008
Trypanosoma brucei cytochrome P450, putative 0.0039 0.0048 0.0047
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0052 0.0076 0.0084
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.003 0.0027 0.0568
Schistosoma mansoni sodium/chloride dependent transporter 0.0077 0.0133 0.0147
Echinococcus multilocularis nmda type glutamate receptor 0.01 0.0183 0.0202
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0093 0.0167 0.0166
Onchocerca volvulus 0.0052 0.0076 0.0079
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0024 0.0015 0.0016
Mycobacterium tuberculosis Conserved protein 0.0036 0.0042 0.0874
Brugia malayi Receptor family ligand binding region containing protein 0.0019 0.0005 0.0005
Echinococcus granulosus bloom syndrome protein 0.0045 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0931 0.2018 0.2017
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.0216 0.0239
Echinococcus multilocularis nmda type glutamate receptor 0.0163 0.0322 0.0356
Echinococcus multilocularis high affinity choline transporter 1 0.0093 0.0167 0.0184
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0045 0.0045
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0093 0.0167 0.7878
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Schistosoma mansoni biogenic amine receptor 0.0063 0.01 0.011
Echinococcus multilocularis neuropeptides capa receptor 0.0063 0.01 0.011
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0363 0.0763 0.0847
Echinococcus multilocularis inositol monophosphatase 1 0.0113 0.0211 0.0234
Loa Loa (eye worm) glutathione reductase 0.005 0.0073 0.0073
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0363 0.0763 0.0847
Schistosoma mansoni high-affinity choline transporter 0.0093 0.0167 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0007 0.0006
Echinococcus multilocularis tyrosine kinase 0.0019 0.0005 0.0005
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0052 0.0076 0.0084
Brugia malayi G protein-coupled receptor 0.0063 0.01 0.01
Echinococcus multilocularis synaptic vesicular amine transporter 0.0381 0.0804 0.0892
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0063 0.01 0.011
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0116 0.0128
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0024 0.0015 0.0015
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.003 0.0027 0.0568
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Echinococcus granulosus 7TM GPCR rhodopsin 0.0063 0.01 0.011
Brugia malayi TAR-binding protein 0.0065 0.0105 0.0105
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0007 0.0006
Echinococcus granulosus synaptic vesicular amine transporter 0.0381 0.0804 0.0892
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0007 0.0006
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0091 0.01
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.004 0.0043
Echinococcus granulosus RUN 0.0021 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0007 0.0007
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0021 0.1527
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Echinococcus multilocularis g protein coupled receptor 0.0063 0.01 0.011
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0045 0.2042
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0032 0.1507
Loa Loa (eye worm) norepinephrine transporter 0.0455 0.0968 0.0968
Echinococcus granulosus 7tm_1 domain containing protein 0.0063 0.01 0.011
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0042 0.0664
Mycobacterium tuberculosis Probable reductase 0.0115 0.0216 0.4575
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0034 0.0037
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0113 0.0211 0.1937
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0063 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0177 0.0353 0.0392
Loa Loa (eye worm) hypothetical protein 0.0027 0.0022 0.0022
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0052 0.0076 0.0084
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0019 0.0005 0.0005
Echinococcus multilocularis orexin receptor type 2 0.0063 0.01 0.011
Brugia malayi Pre-SET motif family protein 0.0032 0.0032 0.0032
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0063 0.01 0.011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0188 0.0188
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0003 0.0003
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0008 0.056
Schistosoma mansoni neuropeptide receptor 0.0063 0.01 0.011
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0216 0.1978
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.003 0.0027 0.1244
Echinococcus granulosus nmda type glutamate receptor 0.01 0.0183 0.0202
Brugia malayi hypothetical protein 0.0024 0.0015 0.0015
Schistosoma mansoni rab6-interacting 0.0021 0.0008 0.0008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0032 0.0035
Echinococcus granulosus single minded 2 0.0041 0.0052 0.0057
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0041 0.0373
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Brugia malayi putative neuropeptide receptor 0.0063 0.01 0.01
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0055 0.006
Echinococcus multilocularis neuropeptide receptor 0.0063 0.01 0.011
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.003 0.0027 0.0568
Echinococcus granulosus nmda type glutamate receptor 0.0163 0.0322 0.0356
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0011 0.0011
Brugia malayi hypothetical protein 0.0024 0.0015 0.0015
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0455 0.0968 0.1074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.01 0.011
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0029 0.2113
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0091 0.01
Echinococcus granulosus neuropeptide Y receptor 0.0063 0.01 0.011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.003 0.0027 0.1244
Echinococcus multilocularis glutamate receptor 2 0.0177 0.0353 0.0392
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.003 0.0027 0.1244
Echinococcus granulosus sodium:glucose cotransporter 2 0.0363 0.0763 0.0847
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.051 0.1088 0.1088
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.003 0.0027 0.1244
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0063 0.01 0.011
Echinococcus multilocularis microtubule associated protein 2 0.143 0.3121 0.3465
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0077 0.0133 0.6288
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0048 0.0047
Loa Loa (eye worm) G-protein coupled receptor 0.0063 0.01 0.01
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0113 0.0211 0.0211
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.0216 0.4575
Echinococcus multilocularis g protein coupled receptor 0.0063 0.01 0.011
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0216 1
Echinococcus granulosus neuropeptides capa receptor 0.0063 0.01 0.011
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0042 0.0379
Brugia malayi Bromodomain containing protein 0.0037 0.0045 0.0045
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0216 0.1978
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0052 0.0076 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0069 0.0076
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0024 0.0015 0.0016
Echinococcus granulosus sodium:myo inositol cotransporter 0.0363 0.0763 0.0847
Schistosoma mansoni sodium/chloride dependent transporter 0.0455 0.0968 0.1074
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0216 0.0239
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0052 0.0076 0.0084
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0048 0.0048
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0073 0.0081
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0024 0.0015 0.0015
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0007 0.013
Brugia malayi Cation transporter family protein 0.0052 0.0076 0.0076
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0113 0.0211 0.1937
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0019 0.0005 0.0005
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0052 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Echinococcus multilocularis glycine receptor subunit beta 0.0052 0.0076 0.0084
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0008 0.056
Brugia malayi beta-lactamase family protein 0.0036 0.0042 0.0042
Echinococcus granulosus neuropeptide receptor A26 0.0063 0.01 0.011
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0073 0.0081
Schistosoma mansoni nAChR subunit 0.0024 0.0015 0.0016
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.0244 0.5177
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0077 0.0133 0.0133
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0028 0.0024 0.0024
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1137 0.2473 0.2746
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.003 0.0027 0.0568
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0019 0.0005 0.0005
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0015 0.0014
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0037
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0052 0.0076 0.0084
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0031 0.226
Loa Loa (eye worm) hypothetical protein 0.0063 0.01 0.01
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.01 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0007 0.0006
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0007 0.0006
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0113 0.0211 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0047 0.0051
Schistosoma mansoni inositol transporter 0.0363 0.0763 0.0847
Brugia malayi hypothetical protein 0.0027 0.0021 0.0021
Schistosoma mansoni growth hormone secretagogue receptor 0.0063 0.01 0.011
Echinococcus granulosus serotonin transporter 0.0455 0.0968 0.1074
Echinococcus granulosus tm gpcr rhodopsin 0.1137 0.2473 0.2746
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0063 0.0101 0.0112
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0063 0.01 0.011
Schistosoma mansoni hypothetical protein 0.0063 0.01 0.011
Schistosoma mansoni lipoxygenase 0.0087 0.0154 0.0171
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0007 0.0007
Leishmania major extracellular receptor, putative 0.0019 0.0005 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.01 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.01 0.011
Echinococcus granulosus survival motor neuron protein 1 0.0488 0.104 0.1155
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.003 0.0027 0.1244
Echinococcus granulosus fmrfamide receptor 0.0063 0.01 0.011
Echinococcus granulosus microtubule associated protein 2 0.143 0.3121 0.3465
Schistosoma mansoni tyrosine kinase 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0023
Loa Loa (eye worm) ACC-1 protein 0.0052 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0015
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0188 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0069 0.0076
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0133 0.9981
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.0216 0.0215
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0023 0.0023
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0063 0.01 0.01
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.006 0.0551
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0063 0.01 0.011
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0007 0.0006
Echinococcus multilocularis sex peptide receptor 0.0063 0.01 0.011
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0052 0.0076 0.0084
Brugia malayi Thioredoxin reductase 0.005 0.0073 0.0073
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0116 0.0116
Echinococcus granulosus high affinity choline transporter 1 0.0093 0.0167 0.0184
Onchocerca volvulus 0.0063 0.01 0.0106
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0077 0.0133 0.6157
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0008 0.0008
Brugia malayi Sodium:solute symporter family protein 0.0093 0.0167 0.0167
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0077 0.0133 0.0132
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0027 0.0027
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0052 0.0076 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.01 0.011
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.003 0.0027 0.0568
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0052 0.0076 0.0076
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.003 0.0027 0.1244
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0042 0.0379
Trypanosoma brucei unspecified product 0.002 0.0007 0.0006
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0077 0.0133 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0032 0.0035
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0077 0.0133 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 422 nM Inhibition of human SGLT1 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake ChEMBL. 23273606
IC50 (binding) = 1590 nM Inhibition of human SGLT2 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake ChEMBL. 23273606

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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