Detailed information for compound 173433

Basic information

Technical information
  • TDR Targets ID: 173433
  • Name: 1,7-Annulated indolocarbazole deriv. 13Bg
  • MW: 409.437 | Formula: C25H19N3O3
  • H donors: 2 H acceptors: 3 LogP: 3 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1Cc2cccc3c2n(C1)c1c3c2c(=O)[nH]c(=O)c2c2c1ccc1c2n(C)cc1
  • InChi: 1S/C25H19N3O3/c1-27-8-7-13-5-6-16-17(22(13)27)19-20(25(31)26-24(19)30)18-15-4-2-3-14-9-12(11-29)10-28(21(14)15)23(16)18/h2-8,12,29H,9-11H2,1H3,(H,26,30,31)
  • InChiKey: FMZCXIHHKPGEAD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin E2 Starlite/ChEMBL References
Homo sapiens cyclin D1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0018 0.0211
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0145 0.0675
Echinococcus multilocularis cyclins 0.0043 0.0184 0.0184
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Onchocerca volvulus Putative RING finger protein 207 0.0019 0.006 0.0085
Loa Loa (eye worm) cyclin domain-containing protein 0.0043 0.0184 0.0328
Trypanosoma cruzi hypothetical protein, conserved 0.0381 0.197 1
Schistosoma mansoni RNA binding protein 0.0381 0.197 0.3509
Schistosoma mansoni mind bomb 0.0019 0.006 0.0107
Echinococcus granulosus cyclin k 0.001 0.0012 0.0012
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0013 0.0056
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0018 0.0029
Plasmodium falciparum zinc finger protein, putative 0.0019 0.006 0.0085
Schistosoma mansoni hypothetical protein 0.0011 0.0016 0.0029
Plasmodium vivax trophozoite exported protein 1, putative 0.0019 0.006 0.0085
Plasmodium falciparum plasmepsin VII 0.0038 0.016 0.0263
Leishmania major cytochrome p450-like protein 0.004 0.0167 0.0792
Mycobacterium leprae Probable lipase LipE 0.0035 0.0145 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0116 0.0206
Leishmania major hypothetical protein, conserved 0.0019 0.006 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Schistosoma mansoni hypothetical protein 0.0011 0.0016 0.0029
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.1071 0.5615 1
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.006 0.2361
Trypanosoma brucei DNA repair protein, putative 0.0019 0.006 0.0297
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0018 0.0211
Toxoplasma gondii RING zinc finger protein 0.0019 0.006 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0013 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Brugia malayi Pepsin A precursor 0.0038 0.016 0.0285
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0145 0.1128
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0046 0.0082
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0011 0.0017 0.0021
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0011 0.0017 0.003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0087 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Brugia malayi hypothetical protein 0.0019 0.006 0.0107
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0107
Trichomonas vaginalis cyclin A, putative 0.0043 0.0184 0.0307
Brugia malayi Egg laying defective protein 4 0.0012 0.002 0.0035
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0063 0.0257
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0381 0.197 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0145 0.0257
Giardia lamblia Hypothetical protein 0.0019 0.006 0.2361
Echinococcus multilocularis ring finger protein 113a 0.0019 0.006 0.006
Brugia malayi YY1-associated factor 2 0.0381 0.197 0.3509
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0023
Brugia malayi Cytochrome P450 family protein 0.004 0.0167 0.0298
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0013 0.0001
Onchocerca volvulus 0.1071 0.5615 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0018 0.0013
Toxoplasma gondii exonuclease III APE 0.002 0.0063 0.009
Schistosoma mansoni hypothetical protein 0.0019 0.006 0.0107
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.004 0.004
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0019 0.006 0.0085
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0018 0.0084
Schistosoma mansoni hypothetical protein 0.0396 0.2048 0.3648
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0857 0.4482 0.4482
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0043 0.0184 0.0184
Loa Loa (eye worm) fli-1 protein 0.0232 0.1185 0.211
Trichomonas vaginalis cyclins, putative 0.0043 0.0184 0.0307
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0013 0.0001
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0013 0.0001
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0049 0.0215 0.1033
Echinococcus multilocularis expressed conserved protein 0.0012 0.002 0.002
Entamoeba histolytica hypothetical protein 0.0019 0.006 0.2361
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0268 0.1306
Mycobacterium leprae putative cytochrome p450 0.0011 0.0018 0.0409
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0049 0.0215 0.1082
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0011 0.0017 0.0007
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0000018229 0.0000018229
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0215 0.0361
Loa Loa (eye worm) cyclin domain-containing protein 0.001 0.0012 0.0022
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0297
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0011 0.0017 0.0007
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0018 0.0211
Echinococcus multilocularis ring and YY1 binding protein 0.0381 0.197 0.197
Schistosoma mansoni fusion 0.0381 0.197 0.3509
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0019 0.006 0.0085
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0038 0.016 0.0285
Brugia malayi Ets-domain containing protein 0.0011 0.0016 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Onchocerca volvulus 0.0381 0.197 0.3494
Echinococcus granulosus RING finger protein 185 0.0019 0.006 0.006
Onchocerca volvulus 0.0381 0.197 0.3494
Loa Loa (eye worm) aspartyl protease 6 0.0038 0.016 0.0285
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0049 0.0215 0.1033
Chlamydia trachomatis DNA topoisomerase I 0.1071 0.5615 1
Toxoplasma gondii aspartyl protease 0.0038 0.016 0.0263
Echinococcus granulosus cyclin t1 0.001 0.0012 0.0012
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0038 0.016 0.0263
Plasmodium falciparum plasmepsin IX 0.0038 0.016 0.0263
Giardia lamblia Zinc finger domain 0.0019 0.006 0.2361
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0011 0.0017 0.0017
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0043 0.0184 0.0877
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0049 0.0215 0.1033
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0011 0.0017 0.003
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0084 0.0403 0.0718
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Echinococcus multilocularis ring finger protein 170 0.0019 0.006 0.006
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0011 0.0017 0.0007
Entamoeba histolytica cyclin, putative 0.0043 0.0184 0.8493
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0011 0.0017 0.0007
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Mycobacterium tuberculosis Conserved protein 0.0035 0.0145 0.1128
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0297
Schistosoma mansoni topbp1 0.001 0.0013 0.0023
Schistosoma mansoni ap endonuclease 0.002 0.0063 0.0112
Brugia malayi Cyclin C 0.001 0.0012 0.0022
Echinococcus multilocularis cyclin G2 0.001 0.0012 0.0012
Leishmania major hypothetical protein, conserved 0.0019 0.006 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Toxoplasma gondii hypothetical protein 0.0019 0.006 0.0085
Schistosoma mansoni cyclins 0.0043 0.0184 0.0328
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0011 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0107
Loa Loa (eye worm) RING finger protein 20 0.0019 0.006 0.0107
Plasmodium vivax plasmepsin IV, putative 0.0038 0.016 0.0263
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0018 0.0013
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Plasmodium vivax plasmepsin V, putative 0.0038 0.016 0.0263
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Echinococcus granulosus cyclin B3 1 0.0043 0.0184 0.0184
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0038 0.016 0.0263
Leishmania major cytochrome p450-like protein 0.0011 0.0018 0.0029
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.016 0.0285
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.002 0.0035
Echinococcus multilocularis cyclins 0.0043 0.0184 0.0184
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0063 0.0113
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0046 0.006
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0018 0.0211
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0018 0.0211
Echinococcus multilocularis cyclin b3 0.0043 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0381 0.197 0.3509
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0013 0.0023
Brugia malayi hypothetical protein 0.0019 0.006 0.0107
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0063 0.0112
Toxoplasma gondii aspartyl protease ASP1 0.0038 0.016 0.0263
Onchocerca volvulus 0.0035 0.0145 0.0236
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0268 0.0478
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0145 0.5159
Echinococcus multilocularis cyclin y 0.001 0.0012 0.0012
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0019 0.006 0.0085
Plasmodium falciparum RING zinc finger protein, putative 0.0019 0.006 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.0381 0.197 1
Schistosoma mansoni cytochrome P450 0.0011 0.0018 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0017 0.0007
Echinococcus granulosus cyclin G2 0.001 0.0012 0.0012
Brugia malayi hypothetical protein 0.0019 0.006 0.0107
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0019 0.006 0.0085
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0013 0.0001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0145 0.0257
Trichomonas vaginalis set domain proteins, putative 0.0233 0.1189 0.2101
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0017 0.003
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0011 0.0017 0.0007
Brugia malayi Cyclin, N-terminal domain containing protein 0.001 0.0012 0.0022
Brugia malayi Cytochrome P450 family protein 0.0011 0.0018 0.0032
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0018 0.0409
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0116 0.0206
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Echinococcus multilocularis cyclin G2 0.001 0.0012 0.0012
Onchocerca volvulus 0.0381 0.197 0.3494
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0577 0.1027
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0145 0.0236
Leishmania major hypothetical protein, conserved 0.0011 0.0017 0.0021
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0013 0.0015
Echinococcus granulosus cyclins 0.0043 0.0184 0.0184
Echinococcus granulosus Zinc finger RanBP2 type 0.0381 0.197 0.197
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0000018229 0.0000018229
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0145 0.0236
Brugia malayi Cyclin, N-terminal domain containing protein 0.0043 0.0184 0.0328
Plasmodium vivax DNA repair protein RAD5, putative 0.0019 0.006 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0019 0.006 0.006
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.3536 0.6297
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0084 0.0403 0.0403
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0017 0.0021
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0381 0.197 0.3509
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0213 0.0213
Onchocerca volvulus 0.0035 0.0145 0.0236
Leishmania major hypothetical protein, conserved 0.0019 0.006 0.0244
Plasmodium falciparum plasmepsin III 0.0038 0.016 0.0263
Brugia malayi DKFZp564C0469 protein 0.001 0.0013 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0018 0.0013
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0000018229 0.0000032464
Leishmania major hypothetical protein, conserved 0.0019 0.006 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0063 0.1958
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0046 0.0082
Echinococcus multilocularis cyclin B3 1 0.0043 0.0184 0.0184
Schistosoma mansoni hypothetical protein 0.0164 0.0824 0.1467
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0018 0.0013
Mycobacterium ulcerans hypothetical protein 0.0035 0.0145 0.5159
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0145 0.0236
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0017 0.0007
Trypanosoma cruzi hypothetical protein 0.0019 0.006 0.0244
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0107
Trichomonas vaginalis hypothetical protein 0.0019 0.006 0.0085
Schistosoma mansoni elf1 0.0011 0.0016 0.0029
Mycobacterium tuberculosis Conserved protein 0.0035 0.0145 0.1128
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0381 0.197 0.197
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Loa Loa (eye worm) hypothetical protein 0.0038 0.016 0.0285
Loa Loa (eye worm) hypothetical protein 0.0073 0.0344 0.0613
Loa Loa (eye worm) cyclin C 0.001 0.0012 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.006 0.0244
Brugia malayi beta-lactamase family protein 0.0035 0.0145 0.0257
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.002 0.002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0268 1
Echinococcus granulosus neuropeptide s receptor 0.0447 0.2321 0.2321
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0084 0.0403 0.0718
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0013 0.0001
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.0019 0.006 0.0085
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0145 0.0145
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0145 0.0257
Treponema pallidum catabolite gene activator 0.0011 0.0017 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0038 0.016 0.016
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0017 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0145 0.0257
Giardia lamblia Kinase, NEK 0.002 0.0063 0.2507
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0107
Echinococcus multilocularis cyclins 0.0043 0.0184 0.0184
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1071 0.5615 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0116 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Trichomonas vaginalis cyclin D, putative 0.0043 0.0184 0.0307
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0046 0.0082
Leishmania major cytochrome p450-like protein 0.0011 0.0018 0.0029
Schistosoma mansoni hypothetical protein 0.0164 0.0824 0.1467
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0116 0.0116
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0019 0.006 0.0085
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0016 0.0016
Schistosoma mansoni zinc finger protein 0.0381 0.197 0.3509
Loa Loa (eye worm) hypothetical protein 0.0035 0.0145 0.0257
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0019 0.006 0.006
Loa Loa (eye worm) beta-lactamase 0.0035 0.0145 0.0257
Schistosoma mansoni 60S ribosomal protein L21 0.0013 0.0028 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.006 0.0244
Echinococcus granulosus voltage gated potassium channel 0.0024 0.0087 0.0087
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Echinococcus multilocularis cyclin t1 0.001 0.0012 0.0012
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0362 0.0362
Trypanosoma brucei predicted zinc finger protein 0.0019 0.006 0.0297
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0049 0.0215 0.0382
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0011 0.0017 0.0017
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.0019 0.006 0.0085
Echinococcus granulosus geminin 0.0164 0.0824 0.0824
Leishmania major hypothetical protein, conserved 0.0035 0.0145 0.0675
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0024 0.0087 0.0087
Echinococcus multilocularis cyclin A3 4 0.001 0.0012 0.0012
Toxoplasma gondii helicase, putative 0.0019 0.006 0.0085
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.004 0.0193
Echinococcus granulosus ring and YY1 binding protein 0.0381 0.197 0.197
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0297
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.004 0.004
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.016 0.0263
Leishmania major hypothetical protein, conserved 0.0019 0.006 0.0244
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0019 0.006 0.0244
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.016 0.0285
Loa Loa (eye worm) cyclin domain-containing protein 0.001 0.0012 0.0022
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0048 0.0212 0.0212
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0017 0.0017
Mycobacterium tuberculosis Conserved protein 0.0035 0.0145 0.1128
Schistosoma mansoni ets 0.0011 0.0016 0.0029
Echinococcus multilocularis 0.0019 0.006 0.006
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0381 0.197 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0084 0.0403 0.0403
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.016 0.0285
Brugia malayi hypothetical protein 0.001 0.0012 0.0022
Leishmania major hypothetical protein, conserved 0.0019 0.006 0.0244
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0079 0.0374 0.0645
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Leishmania major protein kinase, putative 0.0012 0.002 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0013 0.0001
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0381 0.197 0.3509
Echinococcus multilocularis cyclin y 0.001 0.0012 0.0012
Brugia malayi isocitrate dehydrogenase 0.0016 0.004 0.0071
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1071 0.5615 1
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.006 0.2361
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0011 0.0017 0.0007
Onchocerca volvulus 0.0019 0.006 0.0085
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0016 0.0016
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0019 0.006 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.006 0.0244
Schistosoma mansoni hypothetical protein 0.1071 0.5615 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0213 0.0379
Schistosoma mansoni peter pan-related 0.0019 0.006 0.0107
Trichomonas vaginalis cyclin B, putative 0.0043 0.0184 0.0307
Brugia malayi beta-lactamase family protein 0.0035 0.0145 0.0257
Trichomonas vaginalis esterase, putative 0.0035 0.0145 0.0236
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0018 0.0013
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Echinococcus granulosus cyclin y 0.001 0.0012 0.0012
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Echinococcus multilocularis neuropeptide s receptor 0.0447 0.2321 0.2321
Leishmania major hypothetical protein, conserved 0.0381 0.197 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0011 0.0017 0.003
Giardia lamblia Hypothetical protein 0.0019 0.006 0.2361
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0049 0.0215 0.0215
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Echinococcus granulosus zinc finger protein Ran binding 0.0381 0.197 0.197
Echinococcus multilocularis smad 0.0008 0.0000018229 0.0000018229
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0016 0.0029
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0017 0.0046 0.0046
Trichomonas vaginalis cyclins, putative 0.0043 0.0184 0.0307
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0116 0.0116
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.002 0.002
Echinococcus multilocularis 0.0011 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.1071 0.5615 1
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0016 0.0029
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0024 0.0087 0.0155
Plasmodium vivax zinc finger protein, putative 0.0019 0.006 0.0085
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.004 0.0193
Leishmania major hypothetical protein, unknown function 0.0019 0.006 0.0244
Giardia lamblia Zinc finger domain 0.0019 0.006 0.2361
Loa Loa (eye worm) cyclin domain-containing protein 0.001 0.0012 0.0022
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.2048 0.2048
Loa Loa (eye worm) cyclin domain-containing protein 0.001 0.0012 0.0022
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0018 0.0211
Schistosoma mansoni rnf5 0.0019 0.006 0.0107
Onchocerca volvulus Huntingtin homolog 0.0129 0.0641 0.1123
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0019 0.006 0.0085
Echinococcus granulosus cGMP dependent protein kinase 0.0012 0.002 0.002
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0297
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0079 0.0374 0.0645
Brugia malayi Ets-domain containing protein 0.0076 0.0362 0.0644
Trypanosoma brucei Flagellar Member 6 0.0011 0.0017 0.0076
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0011 0.0017 0.003
Treponema pallidum cyclic nucleotide binding protein 0.0011 0.0017 0.0774
Loa Loa (eye worm) hypothetical protein 0.0278 0.1428 0.2543
Loa Loa (eye worm) hypothetical protein 0.0129 0.0641 0.1142
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0011 0.0017 0.0021
Echinococcus granulosus ring finger protein 170 0.0019 0.006 0.006
Schistosoma mansoni voltage-gated potassium channel 0.0092 0.0444 0.0791
Echinococcus granulosus cyclins 0.0043 0.0184 0.0184
Echinococcus multilocularis tumor protein p63 0.1901 1 1
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0167 0.0792
Leishmania major cyclin 0.0043 0.0184 0.0877
Schistosoma mansoni peter pan-related 0.0019 0.006 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.016 0.0285
Schistosoma mansoni voltage-gated potassium channel 0.0092 0.0444 0.0791
Loa Loa (eye worm) hypothetical protein 0.0035 0.0145 0.0257
Mycobacterium ulcerans lipase LipD 0.0035 0.0145 0.5159
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0046 0.0046
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Toxoplasma gondii ABC1 family protein 0.0035 0.0145 0.0236
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0362 0.0362
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.004 0.0139
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0046 0.0046
Echinococcus multilocularis nibrin 0.001 0.0013 0.0013
Loa Loa (eye worm) brahma associated protein 0.1071 0.5615 1
Leishmania major hypothetical protein, conserved 0.0019 0.006 0.0244
Leishmania major protein kinase A catalytic subunit 0.0049 0.0215 0.1033
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0023
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0046 0.0082
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.004 0.0049
Trypanosoma brucei mitotic cyclin 6 0.0043 0.0184 0.0927
Trichomonas vaginalis cyclin D, putative 0.0043 0.0184 0.0307
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0019 0.006 0.0085
Toxoplasma gondii hypothetical protein 0.0033 0.013 0.0209
Plasmodium falciparum cyclin 0.0043 0.0184 0.0307
Brugia malayi Cytochrome P450 family protein 0.0011 0.0018 0.0032
Loa Loa (eye worm) histone methyltransferase 0.001 0.0009 0.0016
Onchocerca volvulus 0.0038 0.016 0.0263
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0016 0.0029
Onchocerca volvulus 0.0028 0.0105 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0018 0.0211
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0017 0.0294
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0145 0.0726
Schistosoma mansoni ring finger protein 151 0.0019 0.006 0.0107
Echinococcus multilocularis protein C ets 2 0.0011 0.0016 0.0016
Schistosoma mansoni brg-1 associated factor 0.1071 0.5615 1
Echinococcus multilocularis SWI:SNF matrix associated 0.1071 0.5615 0.5615
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0049 0.0215 0.1033
Plasmodium vivax aspartyl protease, putative 0.0038 0.016 0.0263
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0167 0.6057
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0268 0.0456
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0116 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.006 0.0244
Leishmania major hypothetical protein, conserved 0.0381 0.197 1
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0049 0.0215 0.0361
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0008 0.0015
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0577 0.1027
Echinococcus multilocularis voltage gated potassium channel 0.0024 0.0087 0.0087
Echinococcus granulosus cell growth regulator with ring finger domain 0.0019 0.006 0.006
Brugia malayi cyclin fold protein 1 variant b 0.001 0.0012 0.0022
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0063 0.0407
Echinococcus granulosus protein C ets 2 0.0011 0.0016 0.0016
Entamoeba histolytica PH domain containing protein kinase, putative 0.0049 0.0215 1
Schistosoma mansoni ets-related 0.0011 0.0016 0.0029
Chlamydia trachomatis SWIB complex protein 0.1071 0.5615 1
Echinococcus multilocularis cyclin 0.001 0.0012 0.0012
Echinococcus multilocularis SWI:SNF matrix associated 0.1071 0.5615 0.5615
Leishmania major hypothetical protein, unknown function 0.0011 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0107
Onchocerca volvulus 0.0011 0.0017 0.0007
Onchocerca volvulus 0.0011 0.0017 0.0007
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0019 0.006 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0215 0.0382
Echinococcus granulosus cyclin y 0.001 0.0012 0.0012
Trichomonas vaginalis cyclin B3, putative 0.0043 0.0184 0.0307
Echinococcus multilocularis zinc finger protein Ran binding 0.0381 0.197 0.197
Trypanosoma cruzi hypothetical protein, conserved 0.0381 0.197 1
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.0019 0.006 0.0085
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0013 0.0001
Mycobacterium ulcerans transmembrane transport protein 0.0011 0.0017 0.0151
Schistosoma mansoni hypothetical protein 0.1071 0.5615 1
Schistosoma mansoni cyclin G 0.001 0.0012 0.0022
Toxoplasma gondii hypothetical protein 0.0019 0.006 0.0085
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.004 0.004
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.001 0.0012 0.0022
Giardia lamblia Cyclin A 0.0043 0.0184 0.8493
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0018 0.0013
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0362 0.0644
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.3536 0.3536
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0049 0.0215 0.0215
Echinococcus multilocularis cyclin B 0.0043 0.0184 0.0184
Echinococcus granulosus cyclin B 0.0043 0.0184 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0213 0.0213
Brugia malayi hypothetical protein 0.0146 0.073 0.13
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0145 0.1128
Plasmodium falciparum E3 ubiquitin-protein ligase RNF5, putative 0.0019 0.006 0.0085
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0013 0.0001
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0297
Schistosoma mansoni smad1 5 8 and 0.0008 0.0000018229 0.0000032464
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0000018229 0.0000018229
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.016 0.0285
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.002 0.002
Trichomonas vaginalis cyclin B, putative 0.0043 0.0184 0.0307
Giardia lamblia Hypothetical protein 0.0019 0.006 0.2361
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0107 0.0107
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.004 0.0204
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0016 0.0029
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0048 0.0212 0.0212
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.004 0.004
Schistosoma mansoni hypothetical protein 0.001 0.0012 0.0022
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0017 0.0046 0.0046
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Loa Loa (eye worm) hypothetical protein 0.0028 0.0107 0.0191
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0009 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.002 0.0035
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Onchocerca volvulus Huntingtin homolog 0.0129 0.0641 0.1123
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0381 0.197 0.3509
Trichomonas vaginalis ankyrin, putative 0.0019 0.006 0.0085
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0011 0.0017 0.0007
Plasmodium falciparum cGMP-dependent protein kinase 0.0012 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0029
Onchocerca volvulus 0.0035 0.0145 0.0236
Loa Loa (eye worm) hypothetical protein 0.0049 0.0215 0.0382
Plasmodium falciparum plasmepsin X 0.0038 0.016 0.0263
Mycobacterium ulcerans hypothetical protein 0.0011 0.0017 0.0151
Onchocerca volvulus 0.0043 0.0184 0.0307
Leishmania major protein kinase A catalytic subunit isoform 1 0.0049 0.0215 0.1033
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0087 0.0155
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0145 0.1128
Mycobacterium ulcerans hypothetical protein 0.0011 0.0017 0.0151
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Trypanosoma brucei hypothetical protein, conserved 0.0381 0.197 1
Schistosoma mansoni topbp1 0.001 0.0013 0.0023
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0063 0.0112
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0018 0.0029
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0381 0.197 0.3509
Schistosoma mansoni cpg binding protein 0.0029 0.0113 0.0201
Echinococcus multilocularis cyclins 0.0043 0.0184 0.0184
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0018 0.0029
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.004 0.0049
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0268 0.0268
Echinococcus multilocularis RING finger protein 185 0.0019 0.006 0.006
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0011 0.0017 0.0017
Entamoeba histolytica cyclin family protein 0.0043 0.0184 0.8493
Trichomonas vaginalis cyclin B, putative 0.0043 0.0184 0.0307
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0063 0.009
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0018 0.0013
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0018 0.0013
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0381 0.197 1
Brugia malayi brahma associated protein 60 kDa 0.1071 0.5615 1
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1071 0.5615 0.5615
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0011 0.0017 0.0017
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0019 0.006 0.0107
Loa Loa (eye worm) hypothetical protein 0.0129 0.0641 0.1142
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0011 0.0017 0.0017
Echinococcus granulosus microtubule associated protein 2 0.0677 0.3536 0.3536
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.006 0.0244
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0046 0.006
Toxoplasma gondii ran binding protein 0.0381 0.197 0.3494
Brugia malayi Cyclin, N-terminal domain containing protein 0.0043 0.0184 0.0328
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0024 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0011 0.0017 0.003
Trypanosoma brucei cAMP response protein 1, putative 0.0011 0.0017 0.0076
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0016 0.0029
Plasmodium falciparum plasmepsin VIII, putative 0.0038 0.016 0.0263
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0028 0.005
Brugia malayi Ets-domain containing protein 0.0076 0.0362 0.0644
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0018 0.0211
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.016 0.0285
Echinococcus granulosus cpg binding protein 0.0029 0.0113 0.0113
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0019 0.006 0.006
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0011 0.0017 0.0021
Trichomonas vaginalis ankyrin, putative 0.0019 0.006 0.0085
Brugia malayi brahma associated protein 60 kDa 0.1071 0.5615 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0019 0.006 0.0297
Schistosoma mansoni ap endonuclease 0.002 0.0063 0.0112
Brugia malayi topoisomerase 0.001 0.0013 0.0023
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Loa Loa (eye worm) CYL-1 protein 0.001 0.0012 0.0022
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.004 0.0049
Leishmania major hypothetical protein, conserved 0.0019 0.006 0.0244
Echinococcus multilocularis G1:S specific cyclin D1 0.001 0.0012 0.0012
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0063 0.2487
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0381 0.197 1
Brugia malayi hypothetical protein 0.0019 0.006 0.0107
Echinococcus multilocularis Cyclin L1 0.001 0.0012 0.0012
Giardia lamblia Hypothetical protein 0.0019 0.006 0.2361
Onchocerca volvulus 0.003 0.0116 0.0184
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0145 0.1128
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0018 0.0013
Onchocerca volvulus 0.0019 0.006 0.0085
Toxoplasma gondii hypothetical protein 0.0019 0.006 0.0085
Loa Loa (eye worm) hypothetical protein 0.0043 0.0184 0.0328
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0145 0.0145
Echinococcus multilocularis ets variant gene 4 0.0011 0.0016 0.0016
Onchocerca volvulus 0.0233 0.1189 0.2101
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0063 0.2487
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0049 0.0215 0.0215
Brugia malayi hypothetical protein 0.0019 0.006 0.0107
Trichomonas vaginalis cyclin B, putative 0.0043 0.0184 0.0307
Echinococcus granulosus replication factor c subunit 1 0.001 0.0013 0.0013
Treponema pallidum cyclic nucleotide binding protein 0.0011 0.0017 0.0774
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0018 0.0211
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0018 0.0029
Brugia malayi Zinc finger, C2H2 type family protein 0.0019 0.006 0.0107
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Plasmodium falciparum E3 ubiquitin-protein ligase, putative 0.0019 0.006 0.0085
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.016 0.0285
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Leishmania major protein kinase, putative 0.0012 0.002 0.0036
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.002 0.002
Brugia malayi Fli-1 protein 0.0232 0.1185 0.211
Echinococcus multilocularis cpg binding protein 0.0029 0.0113 0.0113
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0011 0.0017 0.003
Leishmania major hypothetical protein, conserved 0.0011 0.0017 0.0021
Schistosoma mansoni smad 0.0008 0.0000018229 0.0000032464
Trichomonas vaginalis cyclins, putative 0.0043 0.0184 0.0307
Leishmania major hypothetical protein, conserved 0.0019 0.006 0.0244
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0107
Leishmania major hypothetical protein, conserved 0.0019 0.006 0.0244
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0213 0.0213
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0297
Echinococcus multilocularis cyclins 0.0043 0.0184 0.0184
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0018 0.0013
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0018 0.0018
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0019 0.006 0.0085
Onchocerca volvulus Protein neuralized homolog 0.0019 0.006 0.0085
Echinococcus granulosus cyclins 0.0043 0.0184 0.0184
Schistosoma mansoni cpg binding protein 0.0028 0.0105 0.0186
Echinococcus granulosus cyclins 0.001 0.0012 0.0012
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.006 0.2361
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0018 0.0013
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0046 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0275 0.049
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0116 0.0184
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0019 0.006 0.006
Schistosoma mansoni cyclin B3 0.0043 0.0184 0.0328
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0038 0.016 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0184 0.0307
Echinococcus granulosus neuropeptide receptor A26 0.0447 0.2321 0.2321
Plasmodium falciparum plasmepsin VI 0.0038 0.016 0.0263
Echinococcus multilocularis cyclin k 0.001 0.0012 0.0012
Brugia malayi Cyclin, N-terminal domain containing protein 0.001 0.0012 0.0022
Brugia malayi SWIB/MDM2 domain containing protein 0.1071 0.5615 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0145 0.0236
Brugia malayi Cyclin, N-terminal domain containing protein 0.001 0.0012 0.0022
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0011 0.0017 0.0017
Schistosoma mansoni g1/s-specific cyclin C 0.001 0.0012 0.0022
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0213 0.0379
Loa Loa (eye worm) hypothetical protein 0.0146 0.073 0.13
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0381 0.197 0.197
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0018 0.0211
Echinococcus granulosus cyclins 0.0043 0.0184 0.0184
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0018 0.0211
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0116 0.0206
Brugia malayi Cytochrome P450 family protein 0.004 0.0167 0.0298
Treponema pallidum catabolite gene activator (Crp) 0.0011 0.0017 0.0774
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0268 0.0478
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0011 0.0017 0.003
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0016 0.0016
Echinococcus multilocularis cyclins 0.0043 0.0184 0.0184
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0116 0.0206
Leishmania major protein kinase A regulatory subunit, putative 0.0011 0.0017 0.0021
Toxoplasma gondii AGC kinase 0.0049 0.0215 0.0361
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0013 0.0023
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0145 0.0236
Loa Loa (eye worm) hypothetical protein 0.0038 0.016 0.0285
Loa Loa (eye worm) cytochrome P450 0.0011 0.0018 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0107
Echinococcus granulosus ring finger protein 113a 0.0019 0.006 0.006
Onchocerca volvulus 0.0019 0.006 0.0085
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.003
Brugia malayi hypothetical protein 0.0019 0.006 0.0107
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0019 0.006 0.0107
Giardia lamblia Ser/Thr protein kinase 0.0019 0.006 0.2361
Trichomonas vaginalis ion channel nompc, putative 0.0019 0.006 0.0085
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0013 0.0001
Leishmania major protein kinase A catalytic subunit isoform 2 0.0049 0.0215 0.1033
Brugia malayi beta-lactamase 0.0035 0.0145 0.0257
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0167 0.0792
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.004 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0268 1
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1071 0.5615 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.004 0.004
Schistosoma mansoni zinc finger protein 0.0019 0.006 0.0107
Toxoplasma gondii AGC kinase 0.0049 0.0215 0.0361
Giardia lamblia Kinase, NEK 0.002 0.0063 0.2507
Plasmodium vivax hypothetical protein, conserved 0.1071 0.5615 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.004 0.0071
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0381 0.197 0.197
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0017 0.0046 0.0046
Plasmodium falciparum plasmepsin IV 0.0038 0.016 0.0263
Mycobacterium ulcerans regulatory protein 0.0011 0.0017 0.0151
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0018 0.0211
Plasmodium vivax SET domain protein, putative 0.003 0.0116 0.0184
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0046 0.0082
Onchocerca volvulus 0.0146 0.073 0.1281
Leishmania major hypothetical protein, conserved 0.0019 0.006 0.0244
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0013 0.0001
Loa Loa (eye worm) RiNg Finger protein family member 0.0019 0.006 0.0107
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0023
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0016 0.0016
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0063 0.009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.004 0.004
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0011 0.0017 0.003
Schistosoma mansoni cellular tumor antigen P53 0.0278 0.1428 0.2543
Brugia malayi aspartic protease BmAsp-1, identical 0.0038 0.016 0.0285
Toxoplasma gondii aspartyl protease ASP3 0.0038 0.016 0.0263
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.001 0.0012 0.0055
Toxoplasma gondii hypothetical protein 0.0019 0.006 0.0085
Trypanosoma cruzi protein kinase A regulatory subunit 0.0011 0.0017 0.0021
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0381 0.197 1
Giardia lamblia E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B 0.0019 0.006 0.2361
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0063 0.009
Giardia lamblia Hypothetical protein 0.0043 0.0184 0.8493
Brugia malayi MH2 domain containing protein 0.0117 0.0577 0.1027
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0016 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0268 1
Brugia malayi Eukaryotic aspartyl protease family protein 0.0038 0.016 0.0285
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.004 0.0049
Echinococcus multilocularis geminin 0.0164 0.0824 0.0824
Trypanosoma cruzi cAMP response protein 1 0.0011 0.0017 0.0021
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Brugia malayi Cyclic-nucleotide gated cation channel 0.0017 0.0046 0.0082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0145 0.0257
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.004 0.0139
Schistosoma mansoni hypothetical protein 0.0381 0.197 0.3509
Trypanosoma cruzi WLM domain containing protein, putative 0.0381 0.197 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.016 0.0285
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0381 0.197 0.3494
Brugia malayi Zinc finger protein 183 homolog 0.0019 0.006 0.0107
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0019 0.006 0.0085
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0046 0.0082
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0268 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Giardia lamblia Hypothetical protein 0.0019 0.006 0.2361
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0107
Trypanosoma cruzi cyclin, putative 0.0043 0.0184 0.0877
Brugia malayi RING finger protein 20 0.0019 0.006 0.0107
Onchocerca volvulus 0.001 0.0013 0.0001
Leishmania major regulatory subunit of protein kinase a-like protein 0.0011 0.0017 0.0021
Onchocerca volvulus 0.0381 0.197 0.3494
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0381 0.197 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0297
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0018 0.0211
Schistosoma mansoni TRABID protein (C64 family) 0.0381 0.197 0.3509
Plasmodium falciparum plasmepsin I 0.0038 0.016 0.0263
Trypanosoma cruzi hypothetical protein 0.0019 0.006 0.0244
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.003
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0011 0.0017 0.0007
Giardia lamblia G2/mitotic-specific cyclin B 0.0043 0.0184 0.8493
Trichomonas vaginalis ankyrin, putative 0.0019 0.006 0.0085
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0018 0.0211
Leishmania major hypothetical protein, conserved 0.0381 0.197 1
Onchocerca volvulus 0.0038 0.016 0.0263
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0268 0.2218
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Entamoeba histolytica hypothetical protein 0.0019 0.006 0.2361
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0011 0.0017 0.003
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Schistosoma mansoni gabp alpha 0.0076 0.0362 0.0645
Schistosoma mansoni cyclin G2 0.001 0.0012 0.0022
Trypanosoma cruzi Flagellar Member 6 0.0011 0.0017 0.0021
Trypanosoma brucei cytochrome P450, putative 0.004 0.0167 0.0842
Giardia lamblia Replication factor C, subunit 1 0.001 0.0013 0.0015
Schistosoma mansoni smad1 5 8 and 0.0008 0.0000018229 0.0000032464
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0013 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0029
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0016 0.0016
Echinococcus multilocularis SWI:SNF matrix associated 0.1071 0.5615 0.5615
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0018 0.0013
Trypanosoma brucei cAMP binding protein, putative 0.0011 0.0017 0.0076
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.016 0.0263
Brugia malayi Pre-SET motif family protein 0.003 0.0116 0.0206
Onchocerca volvulus 0.0019 0.006 0.0085
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0107
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0011 0.0017 0.0076
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0063 0.0063
Schistosoma mansoni cyclin k 0.001 0.0012 0.0022
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0019 0.006 0.006
Trypanosoma brucei protein kinase A regulatory subunit 0.0011 0.0017 0.0076
Loa Loa (eye worm) hypothetical protein 0.0035 0.0145 0.0257
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1071 0.5615 0.5615
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0145 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Brugia malayi hypothetical protein 0.0038 0.016 0.0285
Echinococcus granulosus Cyclin L1 0.001 0.0012 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0215 0.0382
Plasmodium falciparum plasmepsin V 0.0038 0.016 0.0263
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0018 0.0013
Mycobacterium ulcerans transcriptional regulatory protein 0.0011 0.0017 0.0151
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0022
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0011 0.0017 0.003
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0297
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0105 0.0186
Trypanosoma brucei cyclin 3 0.001 0.0012 0.0055
Plasmodium vivax aspartyl protease, putative 0.0038 0.016 0.0263
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0016 0.0016
Echinococcus granulosus oligomeric golgi complex subunit 3 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0038 0.016 0.0285
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0145 0.1128
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Entamoeba histolytica cyclin, putative 0.0043 0.0184 0.8493
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0011 0.0017 0.0017
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0011 0.0017 0.0007
Loa Loa (eye worm) cyclin domain-containing protein 0.001 0.0012 0.0022
Brugia malayi hypothetical protein 0.0038 0.016 0.0285
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0016 0.0016
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.001 0.0012 0.0012
Schistosoma mansoni memapsin-2 (A01 family) 0.0953 0.4994 0.8893
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0018 0.0211
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0046 0.0046
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Onchocerca volvulus 0.0019 0.006 0.0085
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0145 0.5159
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0011 0.0017 0.003
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Brugia malayi RING zinc finger protein 0.0019 0.006 0.0107
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0018 0.0211
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.001 0.0012 0.0012
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0063 1
Echinococcus multilocularis cyclins 0.0043 0.0184 0.0184
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0019 0.006 0.006
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0381 0.197 0.3494
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.006 0.2361
Loa Loa (eye worm) hypothetical protein 0.0065 0.0303 0.054
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0017 0.0046 0.0046
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0019 0.006 0.006
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0016 0.0016
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0019 0.006 0.0085
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0038 0.016 0.0285
Echinococcus granulosus cyclin b3 0.0043 0.0184 0.0184
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0019 0.006 0.006
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0011 0.0017 0.003
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1071 0.5615 1
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0167 0.0298
Onchocerca volvulus RING finger protein 141 homolog 0.0019 0.006 0.0085
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0297
Schistosoma mansoni hypothetical protein 0.0011 0.0018 0.0032
Trichomonas vaginalis cyclins, putative 0.0043 0.0184 0.0307
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0019 0.006 0.0085
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0018 0.0013
Entamoeba histolytica hypothetical protein 0.001 0.0013 0.0014
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0019 0.006 0.006
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.006 0.2361
Schistosoma mansoni hypothetical protein 0.001 0.0012 0.0022
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.001 0.0012 0.0022
Echinococcus granulosus cyclins 0.0043 0.0184 0.0184
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0049 0.0215 0.0215
Trypanosoma cruzi WLM domain containing protein, putative 0.0381 0.197 1
Leishmania major DNA repair protein-like protein 0.0019 0.006 0.0244
Brugia malayi Cyclin, N-terminal domain containing protein 0.001 0.0012 0.0022
Trypanosoma brucei ring finger containing protein 0.0019 0.006 0.0297
Entamoeba histolytica PH domain containing protein kinase, putative 0.0049 0.0215 1
Trypanosoma brucei hypothetical protein, conserved 0.0381 0.197 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0011 0.0017 0.0007
Giardia lamblia Kinase, AGC PKA 0.0049 0.0215 1
Echinococcus granulosus dnaJ subfamily B 0.0396 0.2048 0.2048
Onchocerca volvulus 0.0278 0.1428 0.2526
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0145 0.0257
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0145 0.0675
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0063 0.0257
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0063 0.0257
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0019 0.006 0.0244
Giardia lamblia Hypothetical protein 0.0019 0.006 0.2361
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Brugia malayi hypothetical protein 0.001 0.0013 0.0023
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0019 0.006 0.0297
Trichomonas vaginalis cyclins, putative 0.0043 0.0184 0.0307
Loa Loa (eye worm) cyclin domain-containing protein 0.001 0.0012 0.0022
Giardia lamblia Hypothetical protein 0.0019 0.006 0.2361
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0013 0.0001
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0018 0.0211
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.006 0.2361
Loa Loa (eye worm) hypothetical protein 0.0381 0.197 0.3509
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0063 0.009
Echinococcus granulosus G1:S specific cyclin D1 0.001 0.0012 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0167 0.0298
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0016 0.0016
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0018 0.0211
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0011 0.0017 0.0017
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0049 0.0215 0.1082
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0063 0.031
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0046 0.0046
Schistosoma mansoni cpg binding protein 0.0029 0.0113 0.0201
Trichomonas vaginalis cyclin B, putative 0.0043 0.0184 0.0307
Entamoeba histolytica SPRY domain protein 0.0019 0.006 0.2361
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0018 0.0013
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0049 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0043 0.0184 0.0328
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0049 0.0215 0.0361
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0049 0.0215 0.1082
Loa Loa (eye worm) AGC/PKG protein kinase 0.0012 0.002 0.0035
Echinococcus granulosus smad 0.0008 0.0000018229 0.0000018229
Loa Loa (eye worm) hypothetical protein 0.0381 0.197 0.3509
Plasmodium falciparum plasmepsin II 0.0038 0.016 0.0263
Echinococcus granulosus patatin phospholipase domain containing protein 0.0011 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Brugia malayi Cyclin, N-terminal domain containing protein 0.001 0.0012 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0018 0.0013
Echinococcus multilocularis Smad4 0.0008 0.0000018229 0.0000018229
Leishmania major hypothetical protein, conserved 0.0381 0.197 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0145 0.5159
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0049 0.0215 0.0215
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.104 0.1853
Brugia malayi B-box zinc finger family protein 0.0019 0.006 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0046 0.0082
Brugia malayi aspartic protease BmAsp-2, identical 0.0038 0.016 0.0285
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0009 0.0009
Echinococcus granulosus cyclin G2 0.001 0.0012 0.0012
Schistosoma mansoni Smad4 0.0008 0.0000018229 0.0000032464
Schistosoma mansoni Cyclin fold protein 0.001 0.0012 0.0022
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.004 0.0139
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0213 0.0379
Mycobacterium ulcerans hypothetical protein 0.0011 0.0017 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0013 0.0001
Loa Loa (eye worm) hypothetical protein 0.0381 0.197 0.3509
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0018 0.0211
Leishmania major cyclic nucleotide-binding protein-like protein 0.0011 0.0017 0.0021
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1071 0.5615 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0063 0.0063
Brugia malayi CXXC zinc finger family protein 0.0028 0.0105 0.0186
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0019 0.006 0.0085
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.016 0.0285
Schistosoma mansoni DNA ligase IV 0.001 0.0013 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0215 0.0382
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0011 0.0017 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0107
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0145 0.1128
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0013 0.0001
Trypanosoma brucei mitotic cyclin 0.001 0.0012 0.0055
Leishmania major hypothetical protein, conserved 0.0019 0.006 0.0244
Brugia malayi Neuralized family protein 0.0019 0.006 0.0107
Loa Loa (eye worm) hypothetical protein 0.0381 0.197 0.3509
Leishmania major hypothetical protein, conserved 0.0011 0.0017 0.0021
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0011 0.0017 0.0076
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0019 0.006 0.006
Schistosoma mansoni cyclin d 0.001 0.0012 0.0022
Brugia malayi hypothetical protein 0.001 0.0013 0.0023
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0017 0.003
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0049 0.0215 0.0361
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Echinococcus granulosus nibrin 0.001 0.0013 0.0013
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0012 0.002 0.0013
Trypanosoma cruzi cyclin, putative 0.0043 0.0184 0.0877
Brugia malayi hypothetical protein 0.001 0.0012 0.0022
Leishmania major hypothetical protein, conserved 0.0019 0.006 0.0244
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0018 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0087 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0013 0.0001
Leishmania major hypothetical protein 0.0019 0.006 0.0244
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.016 0.0285
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0043 0.0184 0.0184
Echinococcus granulosus cyclin A3 4 0.001 0.0012 0.0012
Plasmodium falciparum trophozoite exported protein 1 0.0019 0.006 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.006 0.0244
Schistosoma mansoni hypothetical protein 0.0019 0.006 0.0107
Brugia malayi N-terminal motif family protein 0.0011 0.0017 0.003
Echinococcus granulosus Smad4 0.0008 0.0000018229 0.0000018229
Trypanosoma cruzi cyclin 6, putative 0.0043 0.0184 0.0877
Trypanosoma brucei cyclin 9 0.001 0.0012 0.0055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0213 0.0213
Brugia malayi Isocitrate dehydrogenase 0.0016 0.004 0.0071
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0023
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1071 0.5615 1
Brugia malayi cytochrome P450 0.0011 0.0018 0.0032
Trypanosoma cruzi cAMP binding protein, putative 0.0011 0.0017 0.0021
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0016 0.0029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0082
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0000018229 0.0000018229
Trypanosoma cruzi CYC2-like cyclin, putative 0.0043 0.0184 0.0877
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0038 0.016 0.0263
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0013 0.0023
Mycobacterium ulcerans hypothetical protein 0.0011 0.0017 0.0151
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0011 0.0017 0.003
Schistosoma mansoni smad1 5 8 and 0.0008 0.0000018229 0.0000032464
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0213 0.0379
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0145 0.1128
Brugia malayi Pre-SET motif family protein 0.0205 0.104 0.1853
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0145 1
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.002 0.0035
Schistosoma mansoni cyclin B 0.0043 0.0184 0.0328
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0018 0.001
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0063 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0213 0.0379
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0046 0.0082
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0018 0.0013
Echinococcus multilocularis neuropeptide receptor A26 0.0447 0.2321 0.2321
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.016 0.0285
Brugia malayi Cyclin, N-terminal domain containing protein 0.0043 0.0184 0.0328
Schistosoma mansoni cyclin l 0.001 0.0012 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0145 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.006 0.0244
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.006 0.2361
Brugia malayi hypothetical protein 0.0129 0.0641 0.1142
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Schistosoma mansoni hypothetical protein 0.0019 0.006 0.0107
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.001 0.0012 0.0012
Giardia lamblia Kinase 0.002 0.0063 0.2507
Plasmodium vivax aspartyl protease, putative 0.0038 0.016 0.0263
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Leishmania major hypothetical protein, conserved 0.0381 0.197 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.001 0.0012 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0085
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0011 0.0017 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0023
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0018 0.0032
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0242 0.0409
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0297
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0046 0.0046
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0011 0.0017 0.0007
Brugia malayi transcription factor E74 isoform 0.0011 0.0016 0.0029
Entamoeba histolytica cyclin family protein 0.0043 0.0184 0.8493
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0017 0.0046 0.0046
Loa Loa (eye worm) CYP4Cod1 0.004 0.0167 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0013 0.0001
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1151 1
Onchocerca volvulus 0.0019 0.006 0.0085
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0381 0.197 0.3494
Trypanosoma cruzi cAMP response protein 1, putative 0.0011 0.0017 0.0021
Plasmodium vivax RING zinc finger protein, putative 0.0019 0.006 0.0085
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0018 0.0013
Entamoeba histolytica zinc finger domain containing protein 0.0019 0.006 0.2361
Schistosoma mansoni ets-related 0.0232 0.1185 0.211
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0297
Echinococcus granulosus SWI:SNF matrix associated 0.1071 0.5615 0.5615
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0018 0.0211
Loa Loa (eye worm) AGC/PKA protein kinase 0.0049 0.0215 0.0382
Brugia malayi Cyclin, N-terminal domain containing protein 0.001 0.0012 0.0022
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0011 0.0017 0.0007
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0381 0.197 1
Giardia lamblia Protein 21.1 0.0019 0.006 0.2361
Loa Loa (eye worm) AGC/PKA protein kinase 0.0049 0.0215 0.0382
Echinococcus granulosus cyclin 0.001 0.0012 0.0012
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0049 0.0215 0.0215
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0019 0.006 0.0244
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0011 0.0017 0.0206
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0022
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0013 0.0001
Giardia lamblia Ribonuclease 0.0019 0.006 0.2361

Activities

Activity type Activity value Assay description Source Reference
Fold increase (functional) = 1.13 G1 cell cycle arrest (fold increase over control) in HCT-116 cells at IC50 ChEMBL. 15149644
Fold increase (functional) = 2.25 G1 cell cycle arrest (fold increase over control) in HCT-116 cells at 3*IC50 ChEMBL. 15149644
IC50 (binding) 0 uM Inhibition of protein kinase A mediated histone phosphorylation (not tested) ChEMBL. 15149644
IC50 (binding) = 0.084 uM Inhibition of Cyclin D1-cyclin-dependent kinase 4. ChEMBL. 15149644
IC50 (binding) = 0.084 uM Inhibition of Cyclin D1-cyclin-dependent kinase 4. ChEMBL. 15149644
IC50 (functional) = 0.21 uM Antiproliferative activity against NCIH-460 (human lung) cell line. ChEMBL. 15149644
IC50 (functional) = 0.21 uM Antiproliferative activity against NCIH-460 (human lung) cell line. ChEMBL. 15149644
IC50 (binding) = 0.65 uM Inhibition of Cyclin E-cyclin-dependent kinase 2 mediated RbING-phosphorylation ChEMBL. 15149644
IC50 (binding) = 0.65 uM Inhibition of Cyclin E-cyclin-dependent kinase 2 mediated RbING-phosphorylation ChEMBL. 15149644
IC50 (functional) = 0.68 uM Antiproliferative activity against HCT-116 (human colon carcinoma) cell line. ChEMBL. 15149644
IC50 (functional) = 0.68 uM Antiproliferative activity against HCT-116 (human colon carcinoma) cell line. ChEMBL. 15149644
S 0 mg ml-1 Solubility measured in 10% solution in EtOH.; NT= not tested ChEMBL. 15149644

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15149644

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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