Detailed information for compound 1763478

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 372.443 | Formula: C21H16N4OS
  • H donors: 1 H acceptors: 3 LogP: 4.52 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1Cc1cc2c(s1)nc(nc2N)c1cccc(c1)C#N
  • InChi: 1S/C21H16N4OS/c1-26-18-8-3-2-6-14(18)10-16-11-17-19(23)24-20(25-21(17)27-16)15-7-4-5-13(9-15)12-22/h2-9,11H,10H2,1H3,(H2,23,24,25)
  • InChiKey: HCPSIVGZIXIKOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0124 0.0087
Entamoeba histolytica hypothetical protein, conserved 0.0036 0.0121 0.4537
Onchocerca volvulus Histone deacetylase 10 homolog 0.0034 0.0113 0.6211
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0071 0.0276
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0036 0.0121 0.4537
Onchocerca volvulus 0.0026 0.008 0.4143
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0071 0.0276
Schistosoma mansoni histone deacetylase 4 5 0.0079 0.0303 0.1172
Brugia malayi hypothetical protein 0.0024 0.0071 0.0276
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0091 0.2433
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Brugia malayi MH2 domain containing protein 0.0008 0.0003 0.0013
Schistosoma mansoni neuropeptide receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0254
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.1659 0.4999
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0132
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0036 0.0121 0.3512
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0036 0.0121 0.0084
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0544 0.2102
Toxoplasma gondii oxidoreductase, putative 0.0036 0.0121 0.2926
Echinococcus granulosus Glutaredoxin protein 5 0.0011 0.0015 0.006
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0036 0.0121 0.9496
Mycobacterium ulcerans ketoacyl reductase 0.0036 0.0121 0.008
Trypanosoma brucei short-chain dehydrogenase, putative 0.0036 0.0121 0.3277
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0071 0.0276
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0124 0.4648
Toxoplasma gondii carbonyl reductase 1, putative 0.0036 0.0121 0.2926
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0037 0.0126 0.0488
Trichomonas vaginalis AGC family protein kinase 0.0019 0.005 0.1882
Schistosoma mansoni histone deacetylase 1 2 3 0.0034 0.0113 0.0437
Echinococcus granulosus neuropeptide receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Leishmania major dehydrogenase-like protein 0.0036 0.0121 0.3277
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0468
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0036 0.0121 0.0084
Echinococcus multilocularis somatostatin receptor 0.0024 0.0071 0.0215
Schistosoma mansoni lamin 0.0026 0.008 0.0308
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0071 0.0215
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0013 0.0051
Echinococcus multilocularis histone deacetylase 3 0.0071 0.0267 0.0804
Echinococcus granulosus neuropeptide receptor 0.0024 0.0071 0.0276
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0071 0.0276
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0056 0.0218
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Leishmania major short chain dehydrogenase/reductase, putative 0.0036 0.0121 0.3277
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0036 0.0121 0.4537
Brugia malayi dehydrogenases, short chain protein 2 0.0036 0.0121 0.0468
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0013 0.0051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0365 0.1099
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0013 0.0039
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0036 0.0121 0.3512
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0071 0.0215
Schistosoma mansoni carbonyl reductase 0.0036 0.0121 0.0468
Loa Loa (eye worm) oxidoreductase 0.0036 0.0121 0.0468
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.016
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0121 0.0468
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.03
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0468
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0121 0.0468
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0071 0.0276
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0071 0.0215
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0499 0.1927
Brugia malayi larval opioid receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0121 0.3512
Brugia malayi hypothetical protein 0.0024 0.0071 0.0276
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0036 0.0121 0.3512
Loa Loa (eye worm) hypothetical protein 0.0029 0.0091 0.0351
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0071 0.0276
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0003 0.0013
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0071 0.0276
Echinococcus granulosus allatostatin A receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0071 0.0276
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0003 0.0013
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0036 0.0121 0.9496
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0071 0.0276
Brugia malayi G protein-coupled receptor 0.0024 0.0071 0.0276
Echinococcus multilocularis neuropeptide s receptor 0.0024 0.0071 0.0215
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0124 0.0373
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0011 0.0015 0.006
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0124 0.0479
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0051
Schistosoma mansoni biogenic amine receptor 0.0024 0.0071 0.0276
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Echinococcus multilocularis carbonyl reductase 1 0.0036 0.0121 0.0365
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Brugia malayi neuropeptide F receptor 0.0024 0.0071 0.0276
Echinococcus granulosus retinol dehydrogenase 11 0.0036 0.0121 0.0468
Brugia malayi neuropeptide F receptor 0.0024 0.0071 0.0276
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0036 0.0121 0.0468
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0036 0.0121 0.4537
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0071 0.0276
Echinococcus multilocularis nervana 2 0.0011 0.0015 0.0047
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0071 0.0215
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0036 0.0121 0.3277
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0041 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0121 0.008
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0071 0.0276
Echinococcus multilocularis histone deacetylase 1 0.0071 0.0267 0.0804
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0036 0.0121 0.3512
Onchocerca volvulus 0.0036 0.0121 0.671
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Schistosoma mansoni amine GPCR 0.0024 0.0071 0.0276
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0071 0.0215
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0013 0.0051
Brugia malayi TAR-binding protein 0.0126 0.0499 0.1927
Echinococcus granulosus histone deacetylase 3 0.0071 0.0267 0.1031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0365 0.1409
Onchocerca volvulus 0.0026 0.008 0.4143
Echinococcus multilocularis serotonin receptor 0.0024 0.0071 0.0215
Schistosoma mansoni carbonyl reductase 0.0036 0.0121 0.0468
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0091 0.2433
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0071 0.0276
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.3512
Loa Loa (eye worm) Smad1 0.0008 0.0003 0.0013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) intermediate filament protein 0.0026 0.008 0.0308
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0121 0.0468
Echinococcus granulosus serine threonine protein kinase nrc 0.0013 0.0022 0.0086
Leishmania major hypothetical protein, conserved 0.0036 0.0121 0.3277
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0071 0.0276
Echinococcus granulosus fmrfamide receptor 0.0024 0.0071 0.0276
Echinococcus multilocularis carbonyl reductase 1 0.0036 0.0121 0.0365
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0066 0.1234
Entamoeba histolytica protein kinase 2, putative 0.0013 0.0022 0.0838
Loa Loa (eye worm) histone deacetylase 1 0.0071 0.0267 0.1031
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0036 0.0121 0.0084
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Loa Loa (eye worm) hypothetical protein 0.0071 0.0267 0.1031
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0013 0.0051
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0036 0.0121 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0479
Loa Loa (eye worm) acetyltransferase 0.0143 0.057 0.2203
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0034 0.0103
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0066 0.0028
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0124 0.3616
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0623 0.2589 1
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0036 0.0121 0.2926
Schistosoma mansoni zinc finger protein 0.0024 0.0071 0.0274
Schistosoma mansoni neuropeptide receptor 0.0024 0.0071 0.0276
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0036 0.0121 0.4038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0071 0.0215
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0013 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0071 0.0276
Echinococcus granulosus FTZ F1 alpha 0.001 0.0013 0.0051
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0036 0.0121 0.3512
Leishmania major short chain dehydrogenase/reductase, putative 0.0036 0.0121 0.3277
Echinococcus granulosus steroid dehydrogenase 0.0036 0.0121 0.0468
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0071 0.0276
Entamoeba histolytica protein kinase, putative 0.0019 0.005 0.1882
Echinococcus multilocularis Glutaredoxin protein 5 0.0011 0.0015 0.0047
Echinococcus granulosus histone deacetylase 6 0.0084 0.0324 0.1253
Echinococcus granulosus retinol dehydrogenase 11 0.0036 0.0121 0.0468
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0036 0.0121 0.4537
Leishmania major quinonoid dihydropteridine reductase 0.0036 0.0121 0.3277
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0071 0.0276
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0034 0.0132
Brugia malayi hypothetical protein 0.0036 0.0121 0.0468
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Brugia malayi follicle stimulating hormone receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0132
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.042
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0479
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Mycobacterium ulcerans hypothetical protein 0.0037 0.0124 0.0083
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0124 0.4648
Schistosoma mansoni opsin-like receptor 0.0024 0.0071 0.0276
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0036 0.0121 0.4537
Plasmodium vivax histone deacetylase 2, putative 0.0079 0.0303 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0124 0.0087
Schistosoma mansoni amine GPCR 0.0024 0.0071 0.0276
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0071 0.0276
Brugia malayi Retinol dehydrogenase 12 0.0036 0.0121 0.0468
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0219 0.6709
Onchocerca volvulus 0.0024 0.0071 0.3627
Trypanosoma brucei oxidoreductase-like protein 0.0036 0.0121 0.3277
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0623 0.2589 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0153 0.5744
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0071 0.0215
Onchocerca volvulus 0.0036 0.0121 0.671
Mycobacterium ulcerans short-chain dehydrogenase 0.0036 0.0121 0.008
Brugia malayi Dopamine receptor 0.0024 0.0071 0.0276
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0132
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0071 0.0276
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0013 0.0051
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0051
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0036 0.0121 0.0468
Brugia malayi hypothetical protein 0.0024 0.0071 0.0276
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0036 0.0121 0.3512
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0071 0.0276
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0036 0.0121 0.0084
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0039 0.0119
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0071 0.0276
Trichomonas vaginalis histone deacetylase, putative 0.0071 0.0267 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0071 0.0215
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0463 0.1787
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0124 0.0374
Echinococcus multilocularis smad 0.0008 0.0003 0.001
Onchocerca volvulus 0.0036 0.0121 0.671
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0036 0.0121 0.0084
Brugia malayi CXXC zinc finger family protein 0.0028 0.0088 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0013 0.0051
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0071 0.0215
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0173 0.0669
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0121 0.008
Onchocerca volvulus 0.0024 0.0071 0.3627
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0036 0.0121 0.0365
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Onchocerca volvulus 0.0024 0.0071 0.3627
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0029 0.0111
Schistosoma mansoni histamine h1 receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0045 0.016 0.0619
Schistosoma mansoni thyroid hormone receptor 0.001 0.0013 0.0051
Onchocerca volvulus 0.0024 0.0071 0.3627
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.057 0.2203
Echinococcus granulosus g protein coupled receptor 0.0024 0.0071 0.0276
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0071 0.0276
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0121 0.0468
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0066 0.0024
Trichomonas vaginalis AGC family protein kinase 0.0019 0.005 0.1882
Leishmania major hypothetical protein, conserved 0.0037 0.0124 0.3385
Schistosoma mansoni adenoreceptor 0.0024 0.0071 0.0276
Echinococcus multilocularis retinol dehydrogenase 11 0.0036 0.0121 0.0365
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0071 0.0276
Loa Loa (eye worm) dehydrogenase 0.0036 0.0121 0.0468
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0124 0.4648
Schistosoma mansoni cpg binding protein 0.0028 0.0088 0.0341
Leishmania major quinonoid dihydropteridine reductase 0.0036 0.0121 0.3277
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0036 0.0121 0.671
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0797 0.3318 1
Brugia malayi GnHR receptor homolog 0.0024 0.0071 0.0276
Schistosoma mansoni bromodomain containing protein 0.0009 0.0008 0.0033
Entamoeba histolytica PH domain containing protein kinase, putative 0.0014 0.0027 0.1009
Brugia malayi hypothetical protein 0.0037 0.0124 0.0479
Echinococcus granulosus smad 0.0008 0.0003 0.0013
Brugia malayi hypothetical protein 0.0024 0.0071 0.0276
Schistosoma mansoni smad1 5 8 and 0.0008 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0051
Echinococcus multilocularis histone deacetylase 6 0.0084 0.0324 0.0977
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0051
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0499 0.1927
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0036 0.0121 0.3512
Brugia malayi beta-lactamase 0.0037 0.0124 0.0479
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0121 0.008
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0036 0.0121 0.0468
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Echinococcus multilocularis carbonyl reductase 1 0.0036 0.0121 0.0365
Mycobacterium ulcerans dehydrogenase 0.0036 0.0121 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0468
Onchocerca volvulus 0.0028 0.0088 0.4679
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0234 0.0707
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0071 0.0215
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0013 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0081
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0051
Mycobacterium ulcerans beta-lactamase 0.0037 0.0124 0.0083
Echinococcus multilocularis steroid dehydrogenase 0.0036 0.0121 0.0365
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0071 0.0276
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0042 0.0162
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.016
Schistosoma mansoni hypothetical protein 0.0024 0.0071 0.0276
Echinococcus granulosus sex peptide receptor 0.0024 0.0071 0.0276
Schistosoma mansoni Smad4 0.0008 0.0003 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0071 0.0215
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.3512
Brugia malayi PHD-finger family protein 0.0029 0.0093 0.0358
Brugia malayi dehydrogenases, short chain protein 9 0.0036 0.0121 0.0468
Onchocerca volvulus 0.0024 0.0071 0.3627
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Schistosoma mansoni myosin xvIII 0.0024 0.0071 0.0276
Echinococcus multilocularis Smad4 0.0008 0.0003 0.001
Brugia malayi Serine/threonine-protein kinase SULU 0.0623 0.2589 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0071 0.0276
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0121 0.0468
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Brugia malayi histone deacetylase 11 0.0034 0.0113 0.0437
Toxoplasma gondii oxidoreductase, putative 0.0036 0.0121 0.2926
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0254
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0036 0.0121 0.4537
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0071 0.0276
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0013 0.0051
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0132
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Trypanosoma cruzi histone deacetylase, putative 0.0079 0.0303 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0068 0.0206
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0174 0.0672
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0036 0.0121 0.0084
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0124 0.0087
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0051
Echinococcus granulosus carbonyl reductase 1 0.0036 0.0121 0.0468
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0033
Entamoeba histolytica short chain dehydrogenase family protein 0.0036 0.0121 0.4537
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0121 0.0468
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0006 0.0025
Mycobacterium tuberculosis Probable dehydrogenase 0.0036 0.0121 0.0084
Schistosoma mansoni coup transcription factor 0.001 0.0013 0.0051
Onchocerca volvulus 0.0024 0.0071 0.3627
Schistosoma mansoni hypothetical protein 0.002 0.0054 0.0208
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0036 0.0121 0.0084
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0153 0.4174
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0036 0.0121 0.4537
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0018 0.0046 0.0176
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0071 0.0276
Trypanosoma cruzi ISWI complex protein 0.0015 0.0032 0.035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0173 0.0669
Mycobacterium tuberculosis Probable oxidoreductase 0.0036 0.0121 0.0084
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0013 0.0022 0.0086
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.016
Schistosoma mansoni opsin-like receptor 0.0024 0.0071 0.0276
Trichomonas vaginalis AGC family protein kinase 0.0019 0.005 0.1882
Echinococcus granulosus tar DNA binding protein 0.0126 0.0499 0.1927
Giardia lamblia Reductase, putative 0.0036 0.0121 0.4038
Schistosoma mansoni smad1 5 8 and 0.0008 0.0003 0.0013
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0071 0.0215
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.016
Brugia malayi histone deacetylase 3 (HD3) 0.0071 0.0267 0.1031
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0071 0.0276
Echinococcus granulosus GPCR family 2 0.0015 0.0034 0.0132
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Mycobacterium leprae Probable oxidoreductase 0.0036 0.0121 0.9496
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Entamoeba histolytica hypothetical protein 0.0037 0.0124 0.4643
Brugia malayi Histone deacetylase family protein 0.0079 0.0303 0.1172
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0124 0.0083
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0066 0.0028
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0036 0.0121 0.2926
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0071 0.0276
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0036 0.0121 0.9496
Echinococcus granulosus g protein coupled receptor 0.0024 0.0071 0.0276
Brugia malayi Histone deacetylase 1 0.0071 0.0267 0.1031
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0071 0.0276
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0071 0.3627
Echinococcus granulosus g protein coupled receptor 0.0024 0.0071 0.0276
Echinococcus multilocularis cpg binding protein 0.0032 0.0103 0.031
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0308
Schistosoma mansoni serine/threonine protein kinase 0.0623 0.2589 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0468
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.057 0.2203
Mycobacterium ulcerans short-chain type oxidoreductase 0.0036 0.0121 0.008
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0036 0.0121 0.3512
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0463 0.1787
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0124 0.0479
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0221 0.0855
Brugia malayi Protein kinase domain containing protein 0.0019 0.005 0.0194
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0071 0.0276
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0036 0.0121 0.0084
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0036 0.0121 0.0365
Trichomonas vaginalis histone deacetylase, putative 0.0071 0.0267 1
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0036 0.0121 0.008
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0036 0.0121 0.3512
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0071 0.0215
Onchocerca volvulus 0.0036 0.0121 0.671
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0254
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Echinococcus granulosus tumor protein p63 0.0332 0.1365 0.5272
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0153 0.4174
Entamoeba histolytica short chain dehydrogenase family protein 0.0036 0.0121 0.4537
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Echinococcus granulosus neuropeptide s receptor 0.0024 0.0071 0.0276
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0036 0.0121 0.3277
Brugia malayi Smad1 0.0008 0.0003 0.0013
Onchocerca volvulus 0.0024 0.0071 0.3627
Loa Loa (eye worm) histone deacetylase 7A 0.0079 0.0303 0.1172
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0036 0.0121 0.4537
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0121 0.008
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0066 0.0024
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0071 0.0215
Schistosoma mansoni histone deacetylase hda2 0.0084 0.0324 0.1253
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0036 0.0121 0.0084
Toxoplasma gondii histone deacetylase HDAC3 0.0071 0.0267 0.858
Schistosoma mansoni hypothetical protein 0.0361 0.1487 0.5743
Mycobacterium tuberculosis Possible oxidoreductase 0.0036 0.0121 0.0084
Entamoeba histolytica histone deacetylase, putative 0.0071 0.0267 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0013 0.0051
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0071 0.0276
Mycobacterium ulcerans short-chain dehydrogenase 0.0036 0.0121 0.008
Schistosoma mansoni hypothetical protein 0.0015 0.0032 0.0124
Leishmania major histone deacetylase, putative 0.0079 0.0303 1
Brugia malayi G-protein coupled receptor 0.0024 0.0071 0.0276
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.2926
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0023 0.0088
Echinococcus multilocularis tumor protein p63 0.0332 0.1365 0.4114
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Trypanosoma brucei short-chain dehydrogenase, putative 0.0036 0.0121 0.3277
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0124 0.0087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0071 0.0276
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0091 0.2433
Loa Loa (eye worm) histone deacetylase 0.0079 0.0303 0.1172
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0066 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Trichomonas vaginalis histone deacetylase, putative 0.0071 0.0267 1
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0036 0.0121 0.0084
Echinococcus granulosus dnaJ subfamily B 0.0402 0.1659 0.6407
Leishmania major hypothetical protein, conserved 0.0036 0.0121 0.3277
Loa Loa (eye worm) hypothetical protein 0.0034 0.0113 0.0437
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0036 0.0121 0.0468
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0066 0.2461
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0254
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Onchocerca volvulus Sepiapterin reductase homolog 0.0036 0.0121 0.671
Toxoplasma gondii histone deacetylase HDAC4 0.0034 0.0113 0.2614
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Trypanosoma brucei histone deacetylase 3 0.0079 0.0303 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0124 0.3616
Echinococcus granulosus histone deacetylase 0.0079 0.0303 0.1172
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Leishmania major histone deacetylase, putative 0.0079 0.0303 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0071 0.0276
Brugia malayi G-protein coupled receptor 0.0024 0.0071 0.0276
Onchocerca volvulus 0.0036 0.0121 0.671
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0071 0.0215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0042 0.0162
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0041 0.0679
Onchocerca volvulus 0.0036 0.0121 0.671
Toxoplasma gondii histone deacetylase HDAC5 0.0034 0.0113 0.2614
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0365 0.1409
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0003 0.0013
Schistosoma mansoni bromodomain containing protein 0.0066 0.0249 0.0962
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0013 0.0039
Mycobacterium ulcerans ketoacyl reductase 0.0036 0.0121 0.008
Brugia malayi hypothetical protein 0.0024 0.0071 0.0276
Echinococcus granulosus neuropeptide receptor A26 0.0024 0.0071 0.0276
Brugia malayi steroid hormone receptor 0.001 0.0013 0.0051
Entamoeba histolytica hypothetical protein 0.0037 0.0124 0.4643
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0071 0.0215
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0121 0.0468
Echinococcus granulosus somatostatin receptor 0.0024 0.0071 0.0276
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0013 0.0051
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0023 0.0069
Echinococcus granulosus serotonin receptor 0.0024 0.0071 0.0276
Echinococcus multilocularis histone deacetylase 6 0.0079 0.0303 0.0915
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0365 0.1409
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0091 0.2159
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0013 0.0051
Loa Loa (eye worm) hypothetical protein 0.0049 0.0174 0.0672
Echinococcus multilocularis musashi 0.0026 0.008 0.024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Loa Loa (eye worm) oxidoreductase 0.0036 0.0121 0.0468
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Leishmania major short chain dehydrogenase-like protein 0.0036 0.0121 0.3277
Echinococcus multilocularis histone deacetylase 0.0079 0.0303 0.0915
Giardia lamblia Hypothetical protein 0.0036 0.0121 0.4038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.016
Echinococcus granulosus cpg binding protein 0.0032 0.0103 0.0398
Echinococcus granulosus histone deacetylase 8 0.0034 0.0113 0.0437
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0036 0.0121 0.008
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0034 0.0132
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0121 0.008
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0124 0.3385
Mycobacterium tuberculosis Conserved protein 0.0037 0.0124 0.0087
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0071 0.0215
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0034 0.0132
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0071 0.0215
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0036 0.0121 0.3512
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0124 0.0479
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0071 0.0215
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0071 0.0276
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0153 0.4657
Echinococcus multilocularis lamin 0.0026 0.008 0.024
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0013 0.0039
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0121 0.008
Schistosoma mansoni amine GPCR 0.0024 0.0071 0.0276
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0071 0.0276
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0071 0.0276
Echinococcus multilocularis neuropeptide receptor A26 0.0024 0.0071 0.0215
Loa Loa (eye worm) oxidoreductase 0.0036 0.0121 0.0468
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0013 0.0022 0.0067
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0066 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Echinococcus granulosus WW domain containing oxidoreductase 0.0036 0.0121 0.0468
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0071 0.0276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0365 0.1409
Loa Loa (eye worm) hypothetical protein 0.0069 0.0258 0.0997
Brugia malayi histone deacetylase 1 (HD1) 0.0071 0.0267 0.1031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0121 0.008
Loa Loa (eye worm) hypothetical protein 0.0046 0.0165 0.0637
Leishmania major hypothetical protein, conserved 0.0036 0.0121 0.3277
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Echinococcus multilocularis zinc finger protein 0.0024 0.0071 0.0214
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0071 0.0215
Onchocerca volvulus 0.0024 0.0071 0.3627
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Mycobacterium ulcerans oxidoreductase 0.0036 0.0121 0.008
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0153 0.0592
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0129 0.4839
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Schistosoma mansoni hypothetical protein 0.0037 0.0124 0.0479
Schistosoma mansoni cpg binding protein 0.0032 0.0103 0.0398
Schistosoma mansoni thyroid hormone receptor 0.001 0.0013 0.0051
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0066 0.0024
Brugia malayi beta-lactamase family protein 0.0037 0.0124 0.0479
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0013 0.0051
Trypanosoma cruzi short chain dehydrogenase, putative 0.0036 0.0121 0.3512
Onchocerca volvulus 0.0037 0.0124 0.6893
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0468
Echinococcus granulosus carbonyl reductase 1 0.0036 0.0121 0.0468
Echinococcus multilocularis steroid dehydrogenase 0.0036 0.0121 0.0365
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.3512
Brugia malayi Dehydrogenases, short chain protein 30 0.0036 0.0121 0.0468
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0036 0.0121 0.3512
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0121 0.008
Echinococcus granulosus carbonyl reductase 1 0.0036 0.0121 0.0468
Schistosoma mansoni smad 0.0008 0.0003 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0013 0.0051
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0071 0.0215
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0066 0.0024
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0014 0.0053
Loa Loa (eye worm) AGC/AKT protein kinase 0.0019 0.005 0.0194
Echinococcus granulosus serine/threonine protein kinase 0.0014 0.0027 0.0104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0071 0.0276
Brugia malayi AKH receptor 0.0024 0.0071 0.0276
Echinococcus multilocularis histone deacetylase 8 0.0034 0.0113 0.0341
Trichomonas vaginalis AGC family protein kinase 0.0019 0.005 0.1882
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0071 0.0215
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0124 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0042 0.0162
Brugia malayi MH1 domain containing protein 0.0008 0.0003 0.0013
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Onchocerca volvulus 0.0036 0.0121 0.671
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0036 0.0121 0.671
Echinococcus granulosus hypothetical protein 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0132
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0121 0.008
Schistosoma mansoni hypothetical protein 0.0033 0.0109 0.042
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Schistosoma mansoni serine/threonine-protein kinase 0.0014 0.0027 0.0104
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0254
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Trichomonas vaginalis AGC family protein kinase 0.0019 0.005 0.1882
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0071 0.0276
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0036 0.0121 0.3277
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0124 0.4648
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0091 0.2433
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.0955 0.0921
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0013 0.0051
Schistosoma mansoni hypothetical protein 0.0024 0.0071 0.0276
Brugia malayi hypothetical protein 0.0024 0.0071 0.0276
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0124 0.0087
Brugia malayi intermediate filament protein 0.0026 0.008 0.0308
Brugia malayi Dopamine receptor protein 2 0.0024 0.0071 0.0276
Echinococcus granulosus intermediate filament protein 0.0026 0.008 0.0308
Echinococcus granulosus carbonyl reductase 1 0.0036 0.0121 0.0468
Giardia lamblia Histone deacetylase 0.0071 0.0267 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0121 0.0468
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Entamoeba histolytica protein kinase, putative 0.0019 0.005 0.1882
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0468
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0071 0.0276
Mycobacterium ulcerans ketoacyl reductase 0.0036 0.0121 0.008
Echinococcus multilocularis retinol dehydrogenase 13 0.0036 0.0121 0.0365
Echinococcus multilocularis transient receptor potential cation channel 0.0036 0.0121 0.0365
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0071 0.0276
Brugia malayi hypothetical protein 0.0019 0.0048 0.0185
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0036 0.0121 0.9496
Brugia malayi ORL1-like opioid receptor 0.0024 0.0071 0.0276
Brugia malayi putative neuropeptide receptor 0.0024 0.0071 0.0276
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Mycobacterium tuberculosis Possible oxidoreductase 0.0036 0.0121 0.0084
Echinococcus multilocularis oxidoreductase 0.0036 0.0121 0.0365
Echinococcus granulosus zinc finger protein 0.0024 0.0071 0.0274
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0013 0.0051
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0124 0.0479
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Brugia malayi hypothetical protein 0.0024 0.0071 0.0276
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0071 0.0276
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0071 0.0215
Mycobacterium ulcerans lipase LipD 0.0037 0.0124 0.0083
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0071 0.0215
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0036 0.0121 0.0365
Plasmodium vivax steroid dehydrogenase, putative 0.0036 0.0121 0.3512
Schistosoma mansoni histone deacetylase 0.0071 0.0267 0.1031
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0365 0.1409
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0109 0.042
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0036 0.0121 0.0365
Onchocerca volvulus 0.0049 0.0174 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0071 0.0276
Brugia malayi beta-lactamase family protein 0.0037 0.0124 0.0479
Onchocerca volvulus 0.0024 0.0071 0.3627
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0468
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0071 0.0276
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0071 0.0215
Onchocerca volvulus 0.0024 0.0071 0.3627
Brugia malayi hypothetical protein 0.0623 0.2589 1
Onchocerca volvulus 0.0024 0.0071 0.3627
Trichomonas vaginalis histone deacetylase, putative 0.0071 0.0267 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.2926
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0071 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0013 0.0051
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0013 0.0039
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0051
Mycobacterium ulcerans short-chain dehydrogenase 0.0036 0.0121 0.008
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0071 0.0276
Schistosoma mansoni amine GPCR 0.0024 0.0071 0.0276
Echinococcus multilocularis sex peptide receptor 0.0024 0.0071 0.0215
Entamoeba histolytica protein kinase, putative 0.0018 0.0046 0.171
Trypanosoma brucei short-chain dehydrogenase, putative 0.0036 0.0121 0.3277
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0071 0.0276
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0124 0.0087
Mycobacterium tuberculosis Conserved protein 0.0037 0.0124 0.0087
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0116 0.0351
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0499 0.1503
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0071 0.0215
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0036 0.0121 0.008
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0041 0.0004
Leishmania major hypothetical protein, conserved 0.0036 0.0121 0.3277
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0036 0.0121 0.0468
Echinococcus multilocularis carbonyl reductase 1 0.0036 0.0121 0.0365
Echinococcus granulosus nervana 2 0.0011 0.0015 0.006
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0234 0.0906
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0124 0.0479
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0091 0.175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0013 0.0051
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0066 0.2461
Leishmania major quinonoid dihydropteridine reductase 0.0036 0.0121 0.3277
Echinococcus granulosus hypothetical protein 0.0036 0.0121 0.0468
Loa Loa (eye worm) beta-lactamase 0.0037 0.0124 0.0479
Echinococcus granulosus hypothetical protein 0.0036 0.0121 0.0468
Echinococcus granulosus Smad4 0.0008 0.0003 0.0013
Onchocerca volvulus 0.0036 0.0121 0.671
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0036 0.0121 0.0468
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0041 0.0679
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0036 0.0121 0.3512
Echinococcus multilocularis GPCR, family 2 0.0015 0.0034 0.0103
Leishmania major hypothetical protein, conserved 0.0029 0.0091 0.2159
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0036 0.0121 0.008
Entamoeba histolytica hypothetical protein 0.0037 0.0124 0.4643
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0034 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0071 0.0276
Mycobacterium ulcerans carveol-like dehydrogenase 0.0036 0.0121 0.008
Echinococcus granulosus lamin dm0 0.0026 0.008 0.0308
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0499 0.1927
Schistosoma mansoni biogenic amine receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0468
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0088 0.0341
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Echinococcus multilocularis histone deacetylase 7 0.0079 0.0303 0.0915
Brugia malayi Melatonin receptor type 1A 0.0024 0.0071 0.0276
Mycobacterium tuberculosis Probable oxidoreductase 0.0036 0.0121 0.0084
Schistosoma mansoni histone deacetylase 4 5 0.0079 0.0303 0.1172
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0071 0.0276
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0124 0.0479
Brugia malayi hypothetical protein 0.0024 0.0071 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0013 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0071 0.0276
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0036 0.0121 0.0468
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0623 0.2589 0.7803
Trypanosoma brucei short-chain dehydrogenase, putative 0.0036 0.0121 0.3277
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0121 0.0468
Leishmania major pteridine reductase 1 0.0036 0.0121 0.3277
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0071 0.0276
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0071 0.0215
Brugia malayi p70 ribosomal S6 kinase beta 0.0018 0.0046 0.0176
Schistosoma mansoni carbonyl reductase 0.0036 0.0121 0.0468
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0071 0.0267 1
Onchocerca volvulus 0.0024 0.0071 0.3627
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0013 0.0051
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0499 0.1927
Echinococcus granulosus geminin 0.0361 0.1487 0.5743
Loa Loa (eye worm) oxidoreductase 0.0036 0.0121 0.0468
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0036 0.0121 0.0084
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0153 0.5744
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0048 0.0173 0.0669
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.3512
Schistosoma mansoni nuclear hormone receptor 0.001 0.0013 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0071 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0013 0.0051
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0036 0.0121 0.3277
Schistosoma mansoni histone deacetylase 0.0071 0.0267 0.1031
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0124 0.0479
Trypanosoma brucei histone deacetylase, putative 0.0079 0.0303 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0071 0.0276
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0071 0.0267 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0365 0.1409
Plasmodium vivax histone deacetylase, putative 0.0079 0.0303 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0006 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0254
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0036 0.0121 0.3512
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0036 0.0121 0.0468
Echinococcus granulosus histone deacetylase 6 0.0079 0.0303 0.1172
Brugia malayi hypothetical protein 0.0036 0.0121 0.0468
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0121 0.0468
Brugia malayi hypothetical protein 0.0029 0.0091 0.0351
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.3512
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0071 0.0276
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0036 0.0121 0.3512
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0013 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0071 0.0215
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0036 0.0121 0.4537
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.008 0.0308
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0034 0.0132
Schistosoma mansoni hypothetical protein 0.0013 0.0024 0.0093
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0036 0.0121 0.3277
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0024 0.0093
Echinococcus multilocularis serotonin receptor 0.0024 0.0071 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0499 0.1927
Onchocerca volvulus 0.0036 0.0121 0.671
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0071 0.0276
Echinococcus granulosus orexin receptor type 2 0.0024 0.0071 0.0276
Schistosoma mansoni amine GPCR 0.0024 0.0071 0.0276
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0124 0.0087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0129 0.4367
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.3512
Leishmania major short chain dehydrogenase, putative 0.0036 0.0121 0.3277
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0036 0.0121 0.4537
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0039 0.0152
Trypanosoma brucei rac serine-threonine kinase, putative 0.0019 0.005 0.0664
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0071 0.0276
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0071 0.0276
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0071 0.0276
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0121 0.0468
Loa Loa (eye worm) hypothetical protein 0.0017 0.0042 0.0162
Mycobacterium tuberculosis Probable oxidoreductase 0.0036 0.0121 0.0084
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0014 0.0027 0.0163
Mycobacterium ulcerans short chain dehydrogenase 0.2387 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Schistosoma mansoni hypothetical protein 0.0024 0.0071 0.0276
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0036 0.0121 0.4537
Brugia malayi sulfakinin receptor protein 0.0024 0.0071 0.0276
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0071 0.0215
Trypanosoma cruzi Protein kinase B 0.0014 0.0027 0.0163
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0091 0.2433
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Schistosoma mansoni zinc finger protein 0.0015 0.0032 0.0124
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0036 0.0121 0.0084
Loa Loa (eye worm) oxidoreductase 0.0036 0.0121 0.0468
Trypanosoma cruzi histone deacetylase 1, putative 0.0071 0.0267 0.8697
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0066 0.2461
Echinococcus granulosus oxidoreductase 0.0036 0.0121 0.0468
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0036 0.0121 0.4537
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0071 0.0276
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0071 0.0276
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0068 0.0265
Brugia malayi Dehydrogenases, short chain protein 2 0.0036 0.0121 0.0468
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0036 0.0121 0.4537
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0036 0.0121 0.4537
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0479
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0005 0.0171
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0013 0.0051
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0036 0.0121 0.4537
Brugia malayi Bromodomain containing protein 0.0078 0.0297 0.1147
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Schistosoma mansoni hypothetical protein 0.0361 0.1487 0.5743
Loa Loa (eye worm) hypothetical protein 0.005 0.0181 0.0699
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0071 0.0215
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0025
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0071 0.0276
Brugia malayi nuclear hormone receptor 0.001 0.0013 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0013 0.0051
Echinococcus multilocularis rac serine:threonine kinase 0.0014 0.0027 0.0081
Schistosoma mansoni smad1 5 8 and 0.0008 0.0003 0.0013
Plasmodium vivax histone deacetylase, putative 0.0034 0.0113 0.3226
Onchocerca volvulus 0.0037 0.0124 0.6893
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0013 0.0051
Onchocerca volvulus 0.0024 0.0071 0.3627
Mycobacterium tuberculosis Probable oxidoreductase 0.0036 0.0121 0.0084
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0036 0.0121 0.2926
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0365 0.1409
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0129 0.3798
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0036 0.0121 0.3512
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0468
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0468
Plasmodium falciparum histone deacetylase, putative 0.0079 0.0303 1
Loa Loa (eye worm) histone deacetylase 3 0.0071 0.0267 0.1031
Entamoeba histolytica hypothetical protein, conserved 0.0036 0.0121 0.4537
Onchocerca volvulus 0.0037 0.0124 0.6893
Trypanosoma brucei histone deacetylase 2 0.0034 0.0113 0.298
Echinococcus multilocularis nervana 2 0.0011 0.0015 0.0047
Schistosoma mansoni retinal dehydrogenase 0.0036 0.0121 0.0468
Trichomonas vaginalis histone deacetylase, putative 0.0071 0.0267 1
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0036 0.0121 0.4537
Leishmania major quinonoid dihydropteridine reductase 0.0036 0.0121 0.3277
Trypanosoma cruzi histone deacetylase, putative 0.0034 0.0113 0.3226
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0013 0.0051
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0071 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0499 0.1927
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Echinococcus granulosus histone deacetylase 6 0.0079 0.0303 0.1172
Onchocerca volvulus 0.0023 0.0066 0.3268
Toxoplasma gondii histone deacetylase HDAC2 0.0071 0.0267 0.858
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0071 0.0276
Onchocerca volvulus 0.0024 0.0071 0.3627
Loa Loa (eye worm) oxidoreductase 0.0036 0.0121 0.0468
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0121 0.008
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0071 0.0215
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0071 0.0276
Onchocerca volvulus 0.0024 0.0071 0.3627
Plasmodium falciparum histone deacetylase 2 0.0079 0.0303 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Brugia malayi Serotonin receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0088
Mycobacterium ulcerans short-chain dehydrogenase 0.0036 0.0121 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0071 0.0276
Echinococcus multilocularis retinol dehydrogenase 11 0.0036 0.0121 0.0365
Leishmania major hypothetical protein, conserved 0.0036 0.0121 0.3277
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0071 0.3627
Entamoeba histolytica PH domain containing protein kinase, putative 0.0014 0.0027 0.1009
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0124 0.3616
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0013 0.0051
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0071 0.0215
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0066 0.1234
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0071 0.0276
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0499 0.1927
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0051
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0121 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0013 0.0051
Loa Loa (eye worm) dehydrogenase 0.0036 0.0121 0.0468
Leishmania major 3-keto-dihydrosphingosine reductase 0.0036 0.0121 0.3277
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0042 0.0126
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0071 0.0215
Leishmania major oxidoreductase-like protein 0.0036 0.0121 0.3277
Brugia malayi MH2 domain containing protein 0.0117 0.0463 0.1787
Schistosoma mansoni lamin 0.0026 0.008 0.0308
Trypanosoma cruzi short chain dehydrogenase, putative 0.0036 0.0121 0.3512
Mycobacterium ulcerans dehydrogenase/reductase 0.0036 0.0121 0.008
Toxoplasma gondii ABC1 family protein 0.0037 0.0124 0.304
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0071 0.0215
Loa Loa (eye worm) histone deacetylase 11 0.0034 0.0113 0.0437
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Mycobacterium tuberculosis Probable oxidoreductase 0.0036 0.0121 0.0084
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0066 0.1234
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.2926
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0013 0.0051
Leishmania major quinonoid dihydropteridine reductase 0.0036 0.0121 0.3277
Brugia malayi Bromodomain containing protein 0.0041 0.014 0.0542
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.2926
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0036 0.0121 0.0084
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0173 0.0669
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0071 0.0215
Echinococcus multilocularis geminin 0.0361 0.1487 0.4481
Brugia malayi RNA binding protein 0.0126 0.0499 0.1927
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0011 0.0015 0.0047
Onchocerca volvulus 0.0036 0.0121 0.671
Schistosoma mansoni hypothetical protein 0.0402 0.1659 0.6407
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Loa Loa (eye worm) oxidoreductase 0.0036 0.0121 0.0468
Loa Loa (eye worm) RNA binding protein 0.0126 0.0499 0.1927
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0013 0.0051
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0036 0.0121 0.0084
Leishmania major histone deacetylase, putative 0.0071 0.0267 0.865
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0365 0.1099
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0124 0.4648
Brugia malayi Histone deacetylase family protein 0.0079 0.0303 0.1172
Echinococcus granulosus histone deacetylase 1 0.0071 0.0267 0.1031
Mycobacterium leprae Probable lipase LipE 0.0037 0.0124 1
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0054 0.0208
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0034 0.0132
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0036 0.0121 0.0084
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0039 0.0152
Onchocerca volvulus 0.0036 0.0121 0.671
Toxoplasma gondii histone deacetylase HDAC1 0.0079 0.0303 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Leishmania major short chain dehydrogenase, putative 0.0036 0.0121 0.3277
Echinococcus granulosus histone deacetylase 7 0.0079 0.0303 0.1172
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.2926
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Brugia malayi Serotonin receptor 0.0024 0.0071 0.0276
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0071 0.0276
Onchocerca volvulus 0.0036 0.0121 0.671
Loa Loa (eye worm) hypothetical protein 0.0043 0.015 0.0581
Trypanosoma cruzi histone deacetylase, putative 0.0034 0.0113 0.3226
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Leishmania major histone deacetylase, putative 0.0071 0.0267 0.865
Schistosoma mansoni biogenic amine receptor 0.0024 0.0071 0.0276
Echinococcus multilocularis lamin dm0 0.0026 0.008 0.024
Echinococcus granulosus lamin 0.0026 0.008 0.0308
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0036 0.0121 0.0468
Schistosoma mansoni serine/threonine-protein kinase 0.0014 0.0027 0.0104
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0013 0.0039
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0121 0.008
Trichomonas vaginalis histone deacetylase, putative 0.0071 0.0267 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0013 0.0051
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0013 0.0051
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0036 0.0121 0.0084
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0024 0.0073
Loa Loa (eye worm) oxidoreductase 0.0036 0.0121 0.0468
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0124 0.0083
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0036 0.0121 0.0468
Schistosoma mansoni neuropeptide receptor 0.0024 0.0071 0.0276
Schistosoma mansoni neuropeptide receptor 0.0024 0.0071 0.0276
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.008 0.0308
Entamoeba histolytica hypothetical protein 0.0037 0.0124 0.4643
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0013 0.0051
Plasmodium falciparum histone deacetylase 1 0.0071 0.0267 0.8697
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0071 0.0215
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0013 0.0039
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Onchocerca volvulus 0.0043 0.0149 0.8459
Schistosoma mansoni cpg binding protein 0.0032 0.0103 0.0398
Schistosoma mansoni intermediate filament proteins 0.0026 0.008 0.0308
Trypanosoma cruzi histone deacetylase, putative 0.0079 0.0303 1
Leishmania major quinonoid dihydropteridine reductase 0.0036 0.0121 0.3277
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.057 0.1719
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0116 0.0449
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0036 0.0121 0.3277
Trichomonas vaginalis esterase, putative 0.0037 0.0124 0.4648
Schistosoma mansoni hypothetical protein 0.0024 0.0071 0.0276
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0013 0.0051
Brugia malayi Dopamine receptor protein 1 0.0024 0.0071 0.0276
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Echinococcus granulosus nervana 2 0.0011 0.0015 0.006
Trypanosoma cruzi ISWI complex protein 0.0015 0.0032 0.035
Brugia malayi ecdysteroid receptor 0.001 0.0013 0.0051
Brugia malayi MH1 domain containing protein 0.0008 0.0003 0.0013
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0013 0.0039
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0479
Brugia malayi oxidoreductase 0.0036 0.0121 0.0468
Trichomonas vaginalis steroid dehydrogenase, putative 0.0036 0.0121 0.4537
Plasmodium falciparum steroid dehydrogenase, putative 0.0036 0.0121 0.3512
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0036 0.0121 0.0365
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0013 0.0051
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0036 0.0121 0.0468
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0013 0.0051
Brugia malayi MH2 domain containing protein 0.0008 0.0003 0.0013
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0013 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0013 0.0051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0036 0.0121 0.3512
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0036 0.0121 0.0084
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0003 0.001
Plasmodium vivax histone deacetylase 1, putative 0.0071 0.0267 0.8697
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0013 0.0051
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0036 0.0121 0.3512
Trypanosoma brucei histone deacetylase 4 0.0079 0.0303 1
Brugia malayi hypothetical protein 0.0024 0.0071 0.0276
Schistosoma mansoni opsin-like receptor 0.0024 0.0071 0.0276
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0013 0.0051
Schistosoma mansoni histone deacetylase hda2 0.0034 0.0113 0.0437
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0081
Leishmania major quinonoid dihydropteridine reductase 0.0036 0.0121 0.3277
Mycobacterium ulcerans oxidoreductase 0.0036 0.0121 0.008
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0013 0.0051
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0121 0.0468
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0479
Mycobacterium ulcerans hypothetical protein 0.0023 0.0066 0.0024
Brugia malayi nuclear receptor NHR-88 0.001 0.0013 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0499 0.1927
Onchocerca volvulus 0.0024 0.0071 0.3627
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0036 0.0121 0.0084
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0276
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0036 0.0121 0.0468
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0013 0.0051
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0071 0.0267 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0036 0.0121 0.3277
Trypanosoma brucei histone deacetylase 1 0.0071 0.0267 0.865
Trypanosoma cruzi histone deacetylase, putative 0.0079 0.0303 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0036 0.0121 0.0084
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0036 0.0121 0.9496
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0039 0.0152
Loa Loa (eye worm) oxidoreductase 0.0036 0.0121 0.0468
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0013 0.0039
Brugia malayi hypothetical protein 0.0024 0.0071 0.0276
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0029 0.0111
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0036 0.0121 0.671
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0003 0.001
Echinococcus multilocularis conserved hypothetical protein 0.0036 0.0121 0.0365
Entamoeba histolytica hypothetical protein 0.0036 0.0121 0.4537
Mycobacterium tuberculosis Conserved protein 0.0037 0.0124 0.0087
Loa Loa (eye worm) hypothetical protein 0.0036 0.0121 0.0468
Trichomonas vaginalis AGC family protein kinase 0.0019 0.005 0.1882
Onchocerca volvulus 0.0024 0.0071 0.3627
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0071 0.0215
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0479
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0003 0.0013
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0071 0.0276
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0068 0.0265
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0066 0.0024
Giardia lamblia Short-chain dehydrogenase, putative 0.0036 0.0121 0.4038
Trichomonas vaginalis AGC family protein kinase 0.0019 0.005 0.1882
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0071 0.0215
Brugia malayi RE15519p 0.0024 0.0071 0.0276
Echinococcus multilocularis histone deacetylase 6 0.0079 0.0303 0.0915
Trypanosoma cruzi histone deacetylase 1, putative 0.0071 0.0267 0.8697

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 6.2 nM Antagonist activity at human adenosine A2a receptor expressed in CHOK1 cells assessed as inhibition of NECA/forskolin-induced cAMP accumulation incubated for 15 mins prior to NECA/forskolin challenge measured after 5.5 to 6 hrs by beta-galactosidase reporter gene assay ChEMBL. 23522563
Ki (functional) = 129 nM Antagonist activity at human adenosine A1 receptor expressed in CHOK1 cells assessed as inhibition of R-PIA/forskolin-induced cAMP accumulation incubated for 15 mins prior to R-PIA/forskolin challenge measured after 5.5 to 6 hrs by beta-galactosidase reporter gene assay ChEMBL. 23522563

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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