Detailed information for compound 18812

Basic information

Technical information
  • TDR Targets ID: 18812
  • Name: (2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoi c acid
  • MW: 160.171 | Formula: C6H12N2O3
  • H donors: 3 H acceptors: 3 LogP: -3.25 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H](C(=O)O)NC(=O)[C@@H](N)C
  • InChi: 1S/C6H12N2O3/c1-3(7)5(9)8-4(2)6(10)11/h3-4H,7H2,1-2H3,(H,8,9)(H,10,11)/t3-,4-/m0/s1
  • InChiKey: DEFJQIDDEAULHB-IMJSIDKUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[(2S)-2-amino-1-oxopropyl]amino]propanoic acid
  • (2S)-2-[[(2S)-2-azanylpropanoyl]amino]propanoic acid
  • (2S)-2-[[(2S)-2-aminopropanoyl]amino]propionic acid
  • (2S)-2-[[(2S)-2-azaniumylpropanoyl]amino]propanoate
  • (2S)-2-[[(2S)-2-ammonio-1-oxopropyl]amino]propanoate
  • (2S)-2-[[(2S)-2-ammoniopropanoyl]amino]propionate
  • alanylalanine
  • (2S)-2-(alanylamino)propionic acid
  • 05250_FLUKA
  • A9502_SIGMA
  • EINECS 217-751-7
  • N-L-Alanyl-L-alanine
  • ZINC01575493

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 15 (oligopeptide transporter), member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) POT family protein Get druggable targets OG5_126717 All targets in OG5_126717
Candida albicans second version of peptide transport protein more similar to S. cerevisiae PTR2 Get druggable targets OG5_126717 All targets in OG5_126717
Brugia malayi POT family protein Get druggable targets OG5_126717 All targets in OG5_126717
Candida albicans second version of peptide transport protein more similar to S. cerevisiae PTR2 Get druggable targets OG5_126717 All targets in OG5_126717
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase kappa 0.0099 0.0284 0.0281
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.0284 0.2537
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0142 0.1248
Brugia malayi ImpB/MucB/SamB family protein 0.0073 0.0196 0.0383
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.0038 0.0075
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0348 0.1119 0.4376
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0263 0.0833 0.0833
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0031 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0338 0.0577
Echinococcus granulosus dnaJ subfamily B 0.0818 0.2693 0.2691
Trichomonas vaginalis phosphofructokinase, putative 0.0348 0.1119 0.1921
Brugia malayi dihydrofolate reductase family protein 0.0046 0.0105 0.0204
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0003 0.0003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0049 0.0115 0.0115
Entamoeba histolytica hypothetical protein 0.0042 0.0092 0.0175
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.006 0.0152 0.015
Loa Loa (eye worm) hypothetical protein 0.0693 0.2273 0.4458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0107 0.0957
Loa Loa (eye worm) hypothetical protein 0.0075 0.0202 0.0397
Brugia malayi PHD-finger family protein 0.0028 0.0046 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0236 0.0742 0.0742
Loa Loa (eye worm) POT family protein 0.0096 0.0274 0.0537
Brugia malayi 6-phosphofructokinase 0.0348 0.1119 0.2192
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0049 0.0115 0.0113
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0017 0.0017
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.01 0.089
Treponema pallidum fructose-bisphosphate aldolase 0.1574 0.5225 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0049 0.0115 0.0225
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0053 0.0735
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0017 0.0031
Brugia malayi Trypsin family protein 0.0022 0.0026 0.005
Trichomonas vaginalis set domain proteins, putative 0.1749 0.5811 1
Echinococcus granulosus dna polymerase eta 0.0073 0.0196 0.0193
Brugia malayi PXA domain containing protein 0.0019 0.0017 0.0031
Schistosoma mansoni hypothetical protein 0.0131 0.0392 0.0392
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0043 0.0096 0.0188
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0182 0.056 0.0558
Schistosoma mansoni rab6-interacting 0.0017 0.0007 0.0007
Echinococcus multilocularis glycoprotein Antigen 5 0.0022 0.0026 0.0024
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0305 0.0974 0.3799
Echinococcus granulosus metabotropic glutamate receptor 5 0.0075 0.0202 0.02
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0028 0.0247
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0057
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.0038 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0049 0.0115 0.0225
Schistosoma mansoni pyruvate kinase 0.0035 0.0068 0.0068
Echinococcus multilocularis expressed protein 0.0378 0.1217 0.1214
Onchocerca volvulus Protein ultraspiracle homolog 0.0049 0.0115 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.0115 0.0225
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0005 0.0044
Schistosoma mansoni cpg binding protein 0.0067 0.0177 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0017 0.0024
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0005 0.0002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0693 0.2273 0.4457
Loa Loa (eye worm) 6-phosphofructokinase 0.0348 0.1119 0.2193
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0053 0.0104
Brugia malayi metabotropic glutamate receptor type 2 0.0044 0.01 0.0195
Entamoeba histolytica hypothetical protein 0.0021 0.0022 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0022 0.0033
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0028 0.0046 0.0089
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0005 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0046 0.041
Toxoplasma gondii endonuclease IV APN 0.008 0.022 0.2726
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0046 0.0107 0.0935
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0046 0.0044
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0068 0.0132
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0123 0.0363 0.0712
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1574 0.5225 0.8991
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0034 0.0066 0.0128
Entamoeba histolytica recQ family helicase, putative 0.0037 0.0074 0.0142
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0103 0.1456
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0255 0.0806 0.0803
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0109 0.0318 0.0315
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0017 0.0017
Schistosoma mansoni retinoic acid receptor RXR 0.0049 0.0115 0.0115
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0081 0.0236
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.0038 0.0038
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0005 0.0002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0029 0.0026
Trypanosoma brucei transcription factor BTF3, putative 0.0111 0.0322 0.2864
Echinococcus granulosus thioredoxin glutathione reductase 0.0134 0.0402 0.0399
Toxoplasma gondii hypothetical protein 0.0051 0.0121 0.1506
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0158 0.048 0.6912
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0038 0.006
Brugia malayi CHD4 protein 0.0017 0.0008 0.0014
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0118 0.0346 0.0346
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0026 0.0026
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0112 0.0109
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0028 0.0028
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0109 0.0318 0.0315
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0233 0.0733 0.0733
Onchocerca volvulus 0.0022 0.0026 0.0044
Schistosoma mansoni ap endonuclease 0.0039 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0541 0.1763 0.1763
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.1003 0.8964
Trypanosoma brucei trypanothione reductase 0.0134 0.04 0.3559
Plasmodium vivax JmjC domain containing protein 0.0016 0.0005 0.004
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0305 0.0974 0.3799
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0017 0.0014
Schistosoma mansoni thyroid hormone receptor 0.018 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0033
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0068 0.0584
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0046 0.0386
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1574 0.5225 0.8991
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0017 0.0014
Leishmania major mitochondrial DNA polymerase beta 0.0314 0.1003 0.8962
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0017 0.0014
Brugia malayi beta-NAC-like protein 0.0111 0.0322 0.0631
Schistosoma mansoni glutamate receptor NMDA 0.0109 0.0318 0.0318
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.0053 0.005
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0091 0.0256 0.0254
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.0038 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0218 0.1927
Brugia malayi Cytochrome P450 family protein 0.003 0.0053 0.0102
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.0449 0.4001
Schistosoma mansoni blooms syndrome DNA helicase 0.0054 0.0133 0.0133
Echinococcus granulosus RUN 0.0017 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0091
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0022 0.0026 0.005
Brugia malayi phosphofructokinase 0.0348 0.1119 0.2192
Echinococcus granulosus nmda type glutamate receptor 0.0182 0.056 0.0558
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0052
Leishmania major hypothetical protein, conserved 0.0028 0.0046 0.0386
Echinococcus granulosus 6 phosphofructokinase 0.0348 0.1119 0.1116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.013 0.013
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0017 0.0014
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1574 0.5225 0.8991
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0022 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.009
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0047 0.0108 0.0108
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0029 0.0026
Trypanosoma cruzi target of rapamycin kinase 3 0.0015 0.0003 0.0024
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0062 0.0122
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0003 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0017 0.0024
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0049 0.0115 0.0115
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0046 0.086
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0346 0.4967
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0081 0.0079
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.022 0.4516
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0046 0.0107 0.0935
Brugia malayi nuclear receptor RXR 0.0023 0.0029 0.0055
Loa Loa (eye worm) dihydrofolate reductase 0.0046 0.0105 0.0206
Brugia malayi Latrophilin receptor protein 2 0.0073 0.0196 0.0382
Loa Loa (eye worm) hypothetical protein 0.0321 0.1027 0.2013
Brugia malayi RNase H family protein 0.0023 0.0029 0.0055
Echinococcus granulosus pyruvate kinase 0.0035 0.0068 0.0065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0012 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.013 0.013
Onchocerca volvulus 0.0118 0.0346 0.0594
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0062 0.012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0009 0.0009
Schistosoma mansoni sodium/chloride dependent transporter 0.0693 0.2273 0.2273
Brugia malayi mbt repeat family protein 0.0048 0.0112 0.0218
Schistosoma mansoni intermediate filament proteins 0.0058 0.0147 0.0147
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0026 0.0026
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0017 0.0031
Plasmodium vivax SET domain protein, putative 0.0222 0.0694 1
Toxoplasma gondii NADPH-glutathione reductase 0.0046 0.0107 0.1329
Loa Loa (eye worm) hypothetical protein 0.0073 0.0196 0.0384
Echinococcus granulosus thyroid hormone receptor alpha 0.0023 0.0029 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.002 0.002 0.002
Brugia malayi nuclear hormone receptor 0.0049 0.0115 0.0225
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0118 0.0346 0.0346
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0115 0.0338 0.3022
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0132 0.0394 0.0753
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.002 0.004
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0017 0.0017
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0151 0.0148
Mycobacterium ulcerans aldehyde dehydrogenase 0.0255 0.0806 0.3127
Echinococcus multilocularis nuclear receptor nhr 48 0.0023 0.0029 0.0026
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.016 0.0313
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0049 0.0115 0.0115
Entamoeba histolytica hypothetical protein 0.0019 0.0017 0.0032
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0029 0.0029
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0029 0.0048
Toxoplasma gondii hypothetical protein 0.0118 0.0346 0.4293
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0322 0.055
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0075
Loa Loa (eye worm) DR-78 0.0023 0.0029 0.0057
Schistosoma mansoni microtubule-associated protein tau 0.3 1 1
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0005 0.0005
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0081 0.0079
Loa Loa (eye worm) glutamate receptor 1 0.0081 0.0223 0.0438
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0107 0.0957
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0079 0.0218 0.1927
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0035 0.0069 0.0134
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0017 0.0017
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0168 0.0166
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0094 0.0267 0.3314
Loa Loa (eye worm) hypothetical protein 0.0049 0.0115 0.0226
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0023 0.0029 0.0026
Echinococcus multilocularis Polycystic kidney disease protein 0.0017 0.0007 0.0005
Echinococcus granulosus glutamate receptor subunit protein glur 0.006 0.0152 0.015
Loa Loa (eye worm) glutathione reductase 0.0134 0.04 0.0784
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0122 0.036 0.0689
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0602 0.1969 0.3769
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.0609 0.0606
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0284 0.2519
Echinococcus granulosus ribonuclease H1 0.0023 0.0029 0.0026
Echinococcus granulosus tyrosine kinase 0.0028 0.0046 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1574 0.5225 0.8991
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0046 0.0107 0.2148
Brugia malayi RNase H family protein 0.0023 0.0029 0.0055
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0339 0.1088 0.4254
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0429 0.0427
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0602 0.1969 0.3386
Schistosoma mansoni serine/threonine protein kinase 0.002 0.002 0.002
Loa Loa (eye worm) phosphofructokinase 0.0348 0.1119 0.2193
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0118 0.0346 0.0343
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0035 0.0069 0.0134
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0123 0.0363 0.0361
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0348 0.1119 0.2141
Giardia lamblia Pyruvate kinase 0.0035 0.0068 0.0125
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0118 0.0346 0.0346
Echinococcus granulosus nmda type glutamate receptor 0.0028 0.0046 0.0044
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0046 0.0044
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0094 0.0267 0.5512
Brugia malayi nuclear receptor RXR 0.0026 0.0038 0.0073
Mycobacterium ulcerans aldehyde dehydrogenase 0.0255 0.0806 0.3127
Echinococcus multilocularis flap endonuclease 1 0.003 0.0053 0.005
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0017 0.0031
Leishmania major DNA damage repair protein, putative 0.0023 0.0028 0.0223
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0052
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0029 0.0259
Onchocerca volvulus 0.0233 0.0733 0.126
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0091
Brugia malayi nuclear hormone receptor family member nhr-6 0.0023 0.0029 0.0055
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0092 0.0089
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0109 0.0318 0.0315
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0049 0.0115 0.0226
Loa Loa (eye worm) glutamate receptor 0.0065 0.0171 0.0335
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0038 0.006
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.006 0.0114
Loa Loa (eye worm) hypothetical protein 0.0118 0.0346 0.0678
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0147 0.0289
Entamoeba histolytica deoxycytidyl transferase, putative 0.0073 0.0196 0.0375
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0037 0.0074 0.064
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0015 0.0003 0.0005
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0029 0.0055
Echinococcus multilocularis transcription factor Dp 1 0.0076 0.0208 0.0205
Brugia malayi nuclear hormone receptor 0.0023 0.0029 0.0055
Giardia lamblia Ribonuclease H 0.0023 0.0029 0.005
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0068 0.0112
Brugia malayi hypothetical protein 0.0022 0.0026 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1574 0.5225 0.8991
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0118 0.0346 0.4293
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0057 0.0144 0.0141
Loa Loa (eye worm) hypothetical protein 0.0027 0.0042 0.0083
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0022 0.0042
Loa Loa (eye worm) hypothetical protein 0.0118 0.0346 0.0678
Echinococcus multilocularis microtubule associated protein 2 0.3 1 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0112 0.0191
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0008 0.0005
Brugia malayi CXXC zinc finger family protein 0.0062 0.016 0.0312
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0049 0.0115 0.0113
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.009
Echinococcus multilocularis FTZ F1 alpha 0.0049 0.0115 0.0113
Onchocerca volvulus 0.0022 0.0026 0.0044
Schistosoma mansoni glutamate receptor AMPA 0.0081 0.0223 0.0223
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0017 0.0017
Entamoeba histolytica phosphofructokinase, putative 0.0348 0.1119 0.2141
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0049 0.0115 0.0113
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0038 0.0038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0049 0.0115 0.0113
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0091
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0017 0.0014
Mycobacterium tuberculosis Probable dehydrogenase 0.0305 0.0974 0.3799
Mycobacterium tuberculosis Probable reductase 0.0305 0.0974 0.3799
Echinococcus multilocularis tyrosine kinase 0.0028 0.0046 0.0044
Brugia malayi polk-prov protein 0.0049 0.0115 0.0225
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0074 0.02 0.0708
Echinococcus multilocularis ecdysone induced protein 78C 0.0049 0.0115 0.0113
Schistosoma mansoni glutamate receptor kainate 0.0081 0.0223 0.0223
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0091 0.0256 0.0256
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0027 0.0024
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0115 0.0338 0.3022
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0068 0.0607
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0046 0.0107 0.0957
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.013 0.0127
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0005 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0132 0.1179
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0038 0.0073
Trypanosoma brucei unspecified product 0.005 0.012 0.1052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0057
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0081 0.0704
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0081 0.0726
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0046 0.0089
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0115 0.0338 0.0663
Schistosoma mansoni nuclear receptor nhr-48 0.0023 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.001
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0134 0.0261
Onchocerca volvulus 0.0058 0.0147 0.0252
Schistosoma mansoni tyrosine kinase 0.0028 0.0046 0.0046
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0011 0.0135
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0158 0.048 0.4281
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0081 0.015
Plasmodium vivax glutathione reductase, putative 0.0134 0.04 0.5748
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0008 0.0008
Brugia malayi Glutamate receptor 2 precursor 0.0081 0.0223 0.0436
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0112 0.0219
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0012 0.0107
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.0284 0.2537
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0107 0.0957
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0033
Giardia lamblia Pyruvate kinase 0.0018 0.0011 0.0017
Brugia malayi conserved hypotetical protein 0.0023 0.0029 0.0055
Echinococcus multilocularis lamin 0.0058 0.0147 0.0144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.0115 0.0225
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.019 0.0588 0.0586
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0048 0.0092
Echinococcus multilocularis dna polymerase eta 0.0073 0.0196 0.0193
Leishmania major DNA polymerase kappa, putative 0.0023 0.0028 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.0115 0.0225
Brugia malayi hypothetical protein 0.0019 0.0017 0.0031
Echinococcus granulosus zinc finger protein 0.0024 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0052
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0017 0.0017
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0112 0.0109
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0158 0.048 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0134 0.0131
Schistosoma mansoni DNA helicase recq1 0.0028 0.0046 0.0046
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0005 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1574 0.5225 0.8991
Echinococcus granulosus glutamate receptor 2 0.0049 0.0117 0.0114
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0099 0.0284 0.0281
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0053 0.0472
Trichomonas vaginalis phosphofructokinase, putative 0.0094 0.0267 0.0455
Trichomonas vaginalis DNA polymerase eta, putative 0.0099 0.0284 0.0484
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0118 0.0346 0.0677
Echinococcus multilocularis lipoxygenase domain containing protein 0.0017 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0049 0.0115 0.0225
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0005 0.0002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0043 0.0041
Brugia malayi mbt repeat family protein 0.0048 0.0112 0.0218
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0003 0.0024
Onchocerca volvulus 0.0028 0.0046 0.0078
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0094 0.0267 0.5512
Trichomonas vaginalis phosphofructokinase, putative 0.0348 0.1119 0.1921
Brugia malayi nuclear hormone receptor family member odr-7 0.0023 0.0029 0.0055
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0011 0.0133
Schistosoma mansoni thyroid hormone receptor 0.018 0.0555 0.0555
Schistosoma mansoni DNA polymerase eta 0.0073 0.0196 0.0196
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0053 0.0658
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0038 0.006
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.019 0.0588 0.0586
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0134 0.0134
Loa Loa (eye worm) ICD-1 protein 0.0111 0.0322 0.0632
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0348 0.1119 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0069 0.0134
Onchocerca volvulus 0.0118 0.0346 0.0594
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0081 0.0223 0.022
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0005 0.0002
Leishmania major DNA polymerase eta, putative 0.0023 0.0028 0.0223
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0046 0.0107 0.0935
Loa Loa (eye worm) hypothetical protein 0.0073 0.0196 0.0384
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0118 0.0346 0.0343
Loa Loa (eye worm) CYP4Cod1 0.003 0.0053 0.0104
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.01 0.0868
Loa Loa (eye worm) doublecortin family protein 0.0017 0.0007 0.0014
Onchocerca volvulus 0.0022 0.0026 0.0044
Brugia malayi Receptor family ligand binding region containing protein 0.0035 0.0069 0.0133
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0769 0.2528 1
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0028 0.0046 0.0044
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0073 0.0196 0.0193
Entamoeba histolytica phosphofructokinase, putative 0.0348 0.1119 0.2141
Schistosoma mansoni hypothetical protein 0.0073 0.0196 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0049 0.0115 0.0225
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0026 0.0026
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.019 0.0588 0.0588
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0033 0.0064
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0103 0.01
Mycobacterium ulcerans hypothetical protein 0.0023 0.0028 0.0021
Loa Loa (eye worm) hypothetical protein 0.0118 0.0346 0.0678
Schistosoma mansoni pyruvate kinase 0.0035 0.0068 0.0068
Echinococcus multilocularis NMDA receptor 0.006 0.0152 0.015
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0158 0.048 0.4295
Brugia malayi PXA domain containing protein 0.0019 0.0017 0.0031
Echinococcus granulosus Polycystic kidney disease protein 0.0017 0.0007 0.0005
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0118 0.0346 0.0343
Plasmodium vivax multidomain scavenger receptor, putative 0.0017 0.0007 0.0074
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0074 0.02 0.4518
Plasmodium falciparum pyruvate kinase 0.0035 0.0068 0.1324
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0118 0.0346 0.0346
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.0392 0.0389
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0109 0.0318 0.0315
Echinococcus multilocularis cpg binding protein 0.0067 0.0177 0.0174
Entamoeba histolytica hypothetical protein 0.0074 0.02 0.0382
Schistosoma mansoni coup transcription factor 0.0049 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.001
Brugia malayi Receptor family ligand binding region containing protein 0.0028 0.0046 0.0089
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.0053 0.005
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0028 0.0223
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0046 0.0871
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0046 0.0107 0.0107
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0094 0.0267 0.0511
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0075
Schistosoma mansoni glutamate receptor AMPA 0.0081 0.0223 0.0223
Mycobacterium ulcerans thymidylate synthase 0.0112 0.0327 0.1218
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.1003 0.8964
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0028 0.0247
Brugia malayi hypothetical protein 0.0018 0.0013 0.0023
Echinococcus granulosus sodium and chloride dependent glycine 0.0118 0.0346 0.0343
Mycobacterium tuberculosis Conserved hypothetical protein 0.0073 0.0196 0.0693
Echinococcus multilocularis glutamate receptor 2 0.0109 0.0318 0.0315
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0023
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0339 0.1088 0.4254
Loa Loa (eye worm) hypothetical protein 0.0693 0.2273 0.4458
Onchocerca volvulus 0.0022 0.0026 0.0044
Schistosoma mansoni hypothetical protein 0.023 0.0724 0.0724
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0068 0.0132
Brugia malayi Metabotropic glutamate receptor precursor. 0.0065 0.0171 0.0333
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0028 0.0342
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0068 0.0116
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0022 0.0041
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0118 0.0346 0.4293
Echinococcus granulosus histone lysine methyltransferase setb 0.0236 0.0742 0.074
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0028 0.0342
Brugia malayi steroid hormone receptor 0.0049 0.0115 0.0225
Echinococcus granulosus L aminoadipate semialdehyde 0.0263 0.0833 0.0831
Toxoplasma gondii histone lysine methyltransferase SET1 0.0131 0.0392 0.486
Loa Loa (eye worm) glutaminase 0.0277 0.0878 0.1722
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0074 0.02 0.2479
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0046 0.0107 0.0935
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0056 0.0109
Plasmodium falciparum thioredoxin reductase 0.0046 0.0107 0.2148
Leishmania major DNA polymerase kappa, putative 0.0079 0.0218 0.1927
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.0028 0.0367
Brugia malayi thymidylate synthase 0.0112 0.0327 0.064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.013 0.0127
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0115 0.0113
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0449 0.4001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0029 0.0026
Loa Loa (eye worm) PHD-finger family protein 0.0017 0.001 0.0019
Entamoeba histolytica hypothetical protein 0.0019 0.0017 0.0032
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0693 0.2273 0.2273
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0017 0.0017
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0054 0.0106
Toxoplasma gondii FATC domain-containing protein 0.0021 0.0022 0.027
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0068 0.0182
Leishmania major cytochrome p450-like protein 0.003 0.0053 0.0449
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0112 0.0112
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0046 0.0107 0.4574
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0081 0.3062
Echinococcus granulosus glutamate receptor 2 0.0109 0.0318 0.0315
Mycobacterium leprae conserved hypothetical protein 0.0074 0.02 0.0708
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0049 0.0115 0.0113
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0046 0.086
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0017 0.0033
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0052
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.02 0.1766
Brugia malayi M-phase phosphoprotein, mpp8 0.0102 0.0295 0.0577
Plasmodium vivax basic transcription factor 3b, putative 0.0111 0.0322 0.4627
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0049 0.0115 0.0115
Toxoplasma gondii target of rapamycin (TOR), putative 0.0015 0.0003 0.0034
Echinococcus multilocularis Mastin 0.0022 0.0026 0.0024
Onchocerca volvulus 0.0048 0.0112 0.0191
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0074 0.02 1
Echinococcus multilocularis dihydrofolate reductase 0.0046 0.0105 0.0102
Onchocerca volvulus 0.0118 0.0346 0.0594
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0284 0.2519
Brugia malayi photoreceptor-specific nuclear receptor 0.0049 0.0115 0.0225
Brugia malayi glutathione reductase 0.0134 0.04 0.0783
Loa Loa (eye worm) nuclear receptor NHR-67 0.0023 0.0029 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0284 0.2519
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0305 0.0974 0.3799
Schistosoma mansoni hypothetical protein 0.0541 0.1763 0.1763
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0081 0.0704
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0107 0.0957
Echinococcus granulosus serine protein kinase ATM 0.0021 0.0022 0.0019
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.0053 0.0122
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0073 0.0196 0.0196
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0028 0.0046 0.0078
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.019 0.0588 0.2259
Schistosoma mansoni phosphoglucomutase 0.0023 0.0029 0.0029
Echinococcus granulosus lipoxygenase domain containing protein 0.0017 0.0007 0.0005
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0151 0.0148
Schistosoma mansoni cpg binding protein 0.0062 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0033
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0112 0.0112
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0109 0.0318 0.0315
Brugia malayi Trypsin-like protease protein 5 0.0022 0.0026 0.005
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0255 0.0806 0.7196
Brugia malayi Bromodomain containing protein 0.0036 0.0072 0.0139
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0118 0.0346 0.0343
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0222 0.0694 0.0692
Schistosoma mansoni bromodomain containing protein 0.006 0.0154 0.0154
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.019 0.0588 0.5247
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0118 0.0346 0.0678
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0118 0.0346 0.0346
Brugia malayi latrophilin 2 splice variant baaae 0.0157 0.0479 0.0937
Schistosoma mansoni sodium/chloride dependent transporter 0.0119 0.0349 0.0349
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0049 0.0115 0.0115
Echinococcus multilocularis neuropeptide s receptor 0.0394 0.127 0.1268
Loa Loa (eye worm) RGC/RGC protein kinase 0.0028 0.0046 0.0091
Brugia malayi Calcitonin receptor-like protein seb-1 0.023 0.0723 0.1416
Schistosoma mansoni pyruvate kinase 0.0018 0.0011 0.0011
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0015 0.0003 0.0025
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.022 0.3143
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.002 0.0038
Toxoplasma gondii exonuclease III APE 0.0039 0.0081 0.1009
Echinococcus granulosus pyruvate kinase 0.0018 0.0011 0.0009
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0109 0.0318 0.0315
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0046 0.0107 0.0957
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0011 0.0141
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0028 0.0247
Trichomonas vaginalis phosphofructokinase, putative 0.0094 0.0267 0.0455
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Echinococcus granulosus flap endonuclease 1 0.003 0.0053 0.005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0073 0.0196 0.0193
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.013 0.0253
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.0392 0.0389
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0151 0.0148
Schistosoma mansoni hypothetical protein 0.0073 0.0196 0.0196
Mycobacterium ulcerans glutaminase 0.0277 0.0878 0.3416
Trypanosoma cruzi trypanothione reductase, putative 0.0134 0.04 0.3575
Echinococcus multilocularis pyruvate kinase 0.0035 0.0068 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0028 0.0247
Leishmania major phosphatidylinositol kinase related protein, putative 0.0015 0.0003 0.0001
Echinococcus multilocularis ribonuclease H1 0.0023 0.0029 0.0026
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0022 0.0019
Echinococcus granulosus glutamate NMDA receptor subunit 0.0081 0.0223 0.022
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.019 0.0588 0.2259
Trichomonas vaginalis phosphofructokinase, putative 0.0348 0.1119 0.1921
Loa Loa (eye worm) RecQ helicase 0.0068 0.0181 0.0355
Schistosoma mansoni glutaminase 0.0277 0.0878 0.0878
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0081 0.0156
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0122 0.036 0.1347
Schistosoma mansoni sodium-dependent amino acid transporter 0.0118 0.0346 0.0346
Trypanosoma brucei DNA polymerase IV, putative 0.0099 0.0284 0.2519
Echinococcus granulosus sodium and chloride dependent glycine 0.0118 0.0346 0.0343
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0005 0.0062
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0057
Toxoplasma gondii phosphofructokinase PFKII 0.0094 0.0267 0.3314
Echinococcus granulosus cpg binding protein 0.0067 0.0177 0.0174
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0023 0.0029 0.0057
Plasmodium falciparum glutathione reductase 0.0134 0.04 0.8306
Brugia malayi Cytochrome P450 family protein 0.003 0.0053 0.0102
Echinococcus multilocularis musashi 0.0058 0.0147 0.0144
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0028 0.0046 0.0091
Leishmania major trypanothione reductase 0.0134 0.04 0.3559
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0026 0.0026
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0118 0.0346 0.0346
Loa Loa (eye worm) RGC/RGC protein kinase 0.0028 0.0046 0.0091
Trichomonas vaginalis DNA helicase recq1, putative 0.0068 0.0181 0.0307
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0021 0.0022 0.0022
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0037 0.0074 0.064
Echinococcus granulosus ecdysone induced protein 78C 0.0049 0.0115 0.0113
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0052
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0023 0.0029 0.0029
Echinococcus granulosus glutamate receptor ionotropic kainate 0.006 0.0152 0.015
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.0115 0.0225
Entamoeba histolytica Flap nuclease, putative 0.003 0.0053 0.0101
Schistosoma mansoni 6-phosphofructokinase 0.0348 0.1119 0.1119
Loa Loa (eye worm) acetyltransferase 0.0149 0.045 0.0882
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0103 0.0173
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0132 0.0394 0.077
Leishmania major ATP-dependent phosphofructokinase 0.0348 0.1119 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0094 0.0267 0.0506
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0068 0.0843
Echinococcus multilocularis transmembrane protease serine 3 0.0022 0.0026 0.0024
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0043 0.0041
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0103 0.1277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0049 0.0115 0.0226
Loa Loa (eye worm) hypothetical protein 0.0263 0.0833 0.1634
Schistosoma mansoni jumonji domain containing protein 0.006 0.0151 0.0151
Entamoeba histolytica hypothetical protein 0.0111 0.0322 0.0617
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.006 0.0739
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0068 0.0584
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0053 0.013 0.1166
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0046 0.0631
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.013 0.022
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0118 0.0346 0.4293
Echinococcus multilocularis pyruvate kinase 0.0018 0.0011 0.0009
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0109 0.0318 0.0315
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.013 0.0127
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1574 0.5225 1
Brugia malayi orphan nuclear receptor NR2E1 0.0023 0.0029 0.0055
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0046 0.0107 0.0104
Loa Loa (eye worm) hypothetical protein 0.0049 0.0115 0.0226
Giardia lamblia DNA damage repair protein 0.0023 0.0028 0.0048
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.006 0.0152 0.015
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0112 0.0327 0.1218
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0053 0.0451
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0017 0.0014
Brugia malayi SET domain containing protein 0.0021 0.0022 0.0042
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0005 0.0005
Leishmania major ribonuclease H1, putative 0.0023 0.0029 0.0235
Brugia malayi RNase H family protein 0.0023 0.0029 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0052
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0091 0.0256 0.0254
Trichomonas vaginalis DNA helicase recq, putative 0.0068 0.0181 0.0307
Schistosoma mansoni lipoxygenase 0.0069 0.0184 0.0184
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.022 0.0788
Brugia malayi Bloom's syndrome protein homolog 0.0068 0.0181 0.0353
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0068 0.0133
Echinococcus multilocularis serine protein kinase ATM 0.0021 0.0022 0.0019
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0022 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0057
Loa Loa (eye worm) hypothetical protein 0.0049 0.0115 0.0226
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0081 0.1143
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0074 0.02 0.2479
Echinococcus multilocularis pyruvate kinase 0.0018 0.0011 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1574 0.5225 0.8991
Entamoeba histolytica phosphofructokinase, putative 0.0348 0.1119 0.2141
Brugia malayi Doublecortin family protein 0.0017 0.0007 0.0013
Toxoplasma gondii NAC domain-containing protein 0.0111 0.0322 0.4001
Schistosoma mansoni serine/threonine protein kinase 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0057
Toxoplasma gondii hypothetical protein 0.0118 0.0346 0.4293
Echinococcus multilocularis neuropeptide receptor A26 0.0394 0.127 0.1268
Echinococcus granulosus mitogen activated protein kinase 3 0.0115 0.0338 0.0335
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0053 0.0104
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0028 0.0223
Schistosoma mansoni 6-phosphofructokinase 0.0348 0.1119 0.1119
Loa Loa (eye worm) norepinephrine transporter 0.0693 0.2273 0.4458
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.238 0.7924 0.7923
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0123 0.0363 0.0711
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0017 0.0024
Trichomonas vaginalis rotamase, putative 0.0032 0.006 0.0098
Echinococcus multilocularis RUN 0.0017 0.0007 0.0005
Echinococcus granulosus bloom syndrome protein 0.0068 0.0181 0.0178
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0134 0.0131
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.0028 0.0476
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0074 0.02 0.0382
Mycobacterium ulcerans endonuclease IV 0.008 0.022 0.0788
Loa Loa (eye worm) hypothetical protein 0.0049 0.0115 0.0226
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0068 0.0133
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0109 0.0318 0.0315
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0284 0.2519
Plasmodium falciparum transporter, putative 0.0118 0.0346 0.7171
Loa Loa (eye worm) hypothetical protein 0.0049 0.0115 0.0226
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0026 0.0026
Brugia malayi hypothetical protein 0.0026 0.0038 0.0073
Entamoeba histolytica transcription factor BTF3, putative 0.0111 0.0322 0.0617
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0133
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.003
Echinococcus granulosus pyruvate kinase 0.0018 0.0011 0.0009
Echinococcus granulosus atrial natriuretic peptide receptor 0.0028 0.0046 0.0044
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0115 0.0115
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0099 0.0284 0.0281
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.006 0.0152 0.015
Trypanosoma brucei unspecified product 0.0093 0.0262 0.2323
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0026 0.0026
Echinococcus multilocularis thymidylate synthase 0.0112 0.0327 0.0325
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0255 0.0806 0.0803
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0073 0.0196 0.0193
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0134 0.04 0.1507
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0769 0.2528 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0046 0.0107 0.0935
Trypanosoma brucei DNA polymerase eta, putative 0.0073 0.0196 0.1731
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0091
Loa Loa (eye worm) hypothetical protein 0.0102 0.0295 0.0578
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0115 0.101
Leishmania major pyruvate kinase 0.0035 0.0068 0.0584
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0074 0.02 0.2855
Schistosoma mansoni phosphoglucomutase 0.0023 0.0029 0.0029
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0033
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0222 0.0694 0.8615
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0168 0.033
Brugia malayi hypothetical protein 0.0023 0.0029 0.0055
Brugia malayi hypothetical protein 0.0118 0.0346 0.0677
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0046 0.0089
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0022 0.0019
Trichomonas vaginalis ribonuclease H1, putative 0.0023 0.0029 0.0045
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.006 0.0153 0.3115
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0022 0.0037
Onchocerca volvulus 0.0102 0.0295 0.0507
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.006 0.0532
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0015 0.0003 0.0005
Echinococcus granulosus pyruvate kinase 0.0018 0.0011 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0049 0.0115 0.0226
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0118 0.0346 0.0677
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0053 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0016 0.0022
Echinococcus multilocularis GPCR, family 2 0.0073 0.0196 0.0193
Onchocerca volvulus 0.0017 0.0007 0.0011
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0123 0.0363 0.0361
Schistosoma mansoni hypothetical protein 0.0157 0.0479 0.0479
Trichomonas vaginalis phosphofructokinase, putative 0.0094 0.0267 0.0455
Echinococcus granulosus serotonin transporter 0.0693 0.2273 0.2271
Loa Loa (eye worm) hypothetical protein 0.0118 0.0346 0.0678
Brugia malayi Trypsin family protein 0.0022 0.0026 0.005
Trichomonas vaginalis phosphofructokinase, putative 0.0094 0.0267 0.0455
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0081 0.0135
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0068 0.095
Leishmania major pyruvate kinase 0.0035 0.0068 0.0584
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0005 0.0005
Loa Loa (eye worm) trypsin family protein 0.0022 0.0026 0.0052
Leishmania major DNA polymerase eta, putative 0.0073 0.0196 0.1731
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0046 0.0107 0.0339
Loa Loa (eye worm) hypothetical protein 0.0027 0.0042 0.0083
Echinococcus multilocularis lipoxygenase domain containing protein 0.0017 0.0007 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0338 0.0577
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0115 0.0113
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0338 0.0577
Echinococcus granulosus metabotropic glutamate receptor 2 0.0059 0.0148 0.0146
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0177 0.0545 0.1069
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0049 0.0115 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0049 0.0115 0.0226
Loa Loa (eye worm) hypothetical protein 0.0055 0.0134 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0017 0.0024
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0084 0.1667
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0068 0.0182
Loa Loa (eye worm) MBCTL1 0.0054 0.0134 0.0263
Echinococcus multilocularis glutamate receptor subunit protein glur 0.006 0.0152 0.015
Echinococcus granulosus lamin dm0 0.0058 0.0147 0.0144
Trichomonas vaginalis glutathione reductase, putative 0.0046 0.0107 0.018
Brugia malayi Pre-SET motif family protein 0.0222 0.0694 0.136
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0023 0.0029 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0322 0.055
Onchocerca volvulus 0.0049 0.0115 0.0197
Schistosoma mansoni zinc finger protein 0.0023 0.0029 0.0029
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0046 0.0107 0.1343
Loa Loa (eye worm) hypothetical protein 0.0054 0.0134 0.0263
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0029 0.0026
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0255 0.0806 0.3127
Echinococcus multilocularis sodium and chloride dependent glycine 0.0118 0.0346 0.0343
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0115 0.0113
Entamoeba histolytica hypothetical protein 0.0042 0.0092 0.0175
Brugia malayi Trypsin family protein 0.0022 0.0026 0.005
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0314 0.1003 0.8962
Schistosoma mansoni mixed-lineage leukemia protein mll 0.014 0.042 0.042
Schistosoma mansoni phosphoglucomutase 0.0023 0.0029 0.0029
Loa Loa (eye worm) thioredoxin reductase 0.0134 0.04 0.0784
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0081 0.0158
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0057
Plasmodium vivax amine transporter, putative 0.0118 0.0346 0.4967
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0005 0.002
Echinococcus granulosus nuclear receptor nhr 48 0.0023 0.0029 0.0026
Plasmodium vivax 6-phosphofructokinase, putative 0.0094 0.0267 0.3828
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0132 0.0394 0.0391
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0017 0.0014
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0081 0.0156
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0017 0.0024
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0007
Trypanosoma cruzi DNA polymerase eta, putative 0.0073 0.0196 0.1752
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0046 0.0105 0.033
Trypanosoma cruzi transcription factor btf3, putative 0.0111 0.0322 0.2882
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0038 0.0073
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0236 0.0742 0.074
Loa Loa (eye worm) hypothetical protein 0.0118 0.0346 0.0678
Echinococcus multilocularis 6 phosphofructokinase 0.0348 0.1119 0.1116
Echinococcus granulosus pyruvate kinase 0.0035 0.0068 0.0065
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0099 0.0284 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0284 0.2519
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0115 0.0338 0.3005
Echinococcus multilocularis dnaJ subfamily B 0.0818 0.2693 0.2691
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0053 0.0087
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0091
Mycobacterium ulcerans 6-phosphofructokinase 0.0348 0.1119 0.4376
Echinococcus granulosus intermediate filament protein 0.0058 0.0147 0.0144
Brugia malayi hypothetical protein 0.0023 0.0029 0.0055
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0158 0.048 0.5963
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0147 0.0289
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0449 0.4016
Loa Loa (eye worm) hypothetical protein 0.0057 0.0144 0.0281
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0107 0.0957
Toxoplasma gondii 6-phosphofructokinase 0.0094 0.0267 0.3314
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.0115 0.0225
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0073 0.0196 0.0193
Onchocerca volvulus 0.0023 0.0029 0.0048
Onchocerca volvulus Ribonuclease H1 homolog 0.0023 0.0029 0.0049
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0029 0.0026
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0046 0.0043
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0081 0.1605
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.0117
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0046 0.0569
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0057 0.0144 0.0141
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0046 0.0107 0.0104
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0037 0.0076 0.0148
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.002 0.0018
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.019 0.0588 0.2259
Brugia malayi intermediate filament protein 0.0058 0.0147 0.0287
Schistosoma mansoni terminal deoxycytidyl transferase 0.0073 0.0196 0.0196
Trichomonas vaginalis phosphofructokinase, putative 0.0094 0.0267 0.0455
Echinococcus multilocularis bloom syndrome protein 0.0068 0.0181 0.0178
Echinococcus multilocularis lamin dm0 0.0058 0.0147 0.0144
Loa Loa (eye worm) hypothetical protein 0.0118 0.0346 0.0678
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0046 0.0392
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0017 0.0017
Onchocerca volvulus 0.1749 0.5811 1
Plasmodium falciparum amino acid transporter, putative 0.0118 0.0346 0.7171
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.006 0.0532
Treponema pallidum ribonuclease H (rnhA) 0.0023 0.0029 0.0055
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1574 0.5225 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0092 0.0089
Echinococcus multilocularis transcription factor btf3 0.0111 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0219
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0003 0.0004
Brugia malayi Flap endonuclease-1 0.003 0.0053 0.0103
Echinococcus granulosus receptor type guanylyl cyclase 0.0028 0.0046 0.0044
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.001
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0122 0.036 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0031 0.0028
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0008
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0084 0.0161
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0029 0.0048
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0038 0.006
Echinococcus granulosus mitogen activated protein kinase 0.0115 0.0338 0.0335
Brugia malayi nuclear receptor NHR-67 0.0023 0.0029 0.0055
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0091
Echinococcus granulosus expressed protein 0.0033 0.0062 0.0059
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0118 0.0346 0.0678
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0008
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0769 0.2528 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0094 0.0267 0.6824
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0081 0.0726
Trypanosoma brucei DNA polymerase IV, putative 0.0093 0.0262 0.2323
Echinococcus multilocularis nmda type glutamate receptor 0.0182 0.056 0.0558
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0023 0.0029 0.0029
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0034 0.0066 0.0128
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.0115 0.0225
Schistosoma mansoni nuclear receptor 0.0023 0.0029 0.0029
Echinococcus multilocularis thioredoxin glutathione reductase 0.0134 0.0402 0.0399
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0005 0.0005
Mycobacterium tuberculosis Probable oxidoreductase 0.0339 0.1088 0.4254
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0046 0.041
Echinococcus granulosus neuropeptide receptor A26 0.0394 0.127 0.1268
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0043 0.0085
Loa Loa (eye worm) glutamate receptor 0.0016 0.0006 0.0011
Schistosoma mansoni hypothetical protein 0.0052 0.0127 0.0127
Brugia malayi nuclear receptor NHR-88 0.0049 0.0115 0.0225
Schistosoma mansoni dihydrofolate reductase 0.0046 0.0105 0.0105
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.023 0.0723 0.1416
Echinococcus multilocularis mitogen activated protein kinase 0.0115 0.0338 0.0335
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0068 0.0182
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0026 0.0026
Schistosoma mansoni sodium/chloride dependent transporter 0.0118 0.0346 0.0346
Loa Loa (eye worm) thymidylate synthase 0.0112 0.0327 0.0642
Plasmodium falciparum LCCL domain-containing protein 0.0017 0.0007 0.005
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0091 0.0256 0.0256
Toxoplasma gondii aldehyde dehydrogenase 0.0255 0.0806 1
Echinococcus multilocularis serotonin transporter 0.0693 0.2273 0.2271
Echinococcus granulosus transmembrane protease serine 3 0.0022 0.0026 0.0024
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0073 0.0196 0.0384
Giardia lamblia Fructose-bisphosphate aldolase 0.1574 0.5225 1
Brugia malayi hypothetical protein 0.0028 0.0046 0.0089
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0026 0.0026
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0026 0.0024
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0305 0.0974 0.3799
Brugia malayi glutaminase DH11.1 0.0277 0.0878 0.1721
Schistosoma mansoni steroid hormone receptor ad4bp 0.0049 0.0115 0.0115
Schistosoma mansoni tyrosine kinase 0.0028 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Entamoeba histolytica hypothetical protein 0.0019 0.0017 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0062 0.0102
Schistosoma mansoni transcription factor btf3 0.0111 0.0322 0.0322
Mycobacterium ulcerans hypothetical protein 0.0165 0.0505 0.1928
Plasmodium falciparum glutathione reductase 0.0046 0.0107 0.2148
Brugia malayi tailless protein 0.0023 0.0029 0.0055
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.045 0.0447
Brugia malayi Bromodomain containing protein 0.007 0.0187 0.0365
Brugia malayi Thioredoxin reductase 0.0134 0.04 0.0783
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0142 0.1248
Schistosoma mansoni hypothetical protein 0.0017 0.001 0.001
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0017 0.0017
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0005 0.0062
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0003 0.0005
Echinococcus multilocularis L aminoadipate semialdehyde 0.0263 0.0833 0.0831
Trypanosoma brucei unspecified product 0.005 0.012 0.1052
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0021 0.0022 0.017
Plasmodium vivax 6-phosphofructokinase, putative 0.0094 0.0267 0.3828
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0284 0.2519
Echinococcus multilocularis enteropeptidase 0.0022 0.0026 0.0024
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0112 0.0327 0.0327
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0118 0.0346 0.0343
Schistosoma mansoni aldehyde dehydrogenase 0.0255 0.0806 0.0806
Brugia malayi Pre-SET motif family protein 0.1537 0.51 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0017 0.0017
Echinococcus granulosus neuropeptide s receptor 0.0394 0.127 0.1268
Entamoeba histolytica hypothetical protein 0.0042 0.0092 0.0175
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1574 0.5225 0.8991
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0046 0.0107 0.0935
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0107 0.0957
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0053 0.0451
Toxoplasma gondii thioredoxin reductase 0.0134 0.04 0.4963
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0118 0.0346 0.0677
Mycobacterium ulcerans DNA polymerase IV 0.0099 0.0284 0.1044
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0112 0.0327 0.1218
Brugia malayi Dihydrofolate reductase 0.0046 0.0105 0.0204
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0074 0.02 0.4097
Echinococcus granulosus lipoxygenase domain containing protein 0.0017 0.0007 0.0005
Brugia malayi MAP kinase sur-1 0.0115 0.0338 0.0662
Schistosoma mansoni polycystin 1-related 0.0017 0.0007 0.0007
Echinococcus granulosus expressed protein 0.0378 0.1217 0.1214
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0094 0.0267 0.0511
Leishmania major phosphopantetheinyl transferase-like protein 0.0074 0.02 0.1766
Loa Loa (eye worm) 6-phosphofructokinase 0.0348 0.1119 0.2193
Chlamydia trachomatis dihydrofolate reductase 0.0046 0.0105 0.1269
Trichomonas vaginalis phosphofructokinase, putative 0.0094 0.0267 0.0455
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0017 0.0014
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0029 0.0259
Brugia malayi Glutamate receptor 1 precursor 0.0081 0.0223 0.0436
Brugia malayi Cytochrome P450 family protein 0.0031 0.0054 0.0105
Echinococcus multilocularis pyruvate kinase 0.0027 0.0043 0.0041
Onchocerca volvulus 0.0058 0.0147 0.0252
Schistosoma mansoni rotamase 0.0033 0.0062 0.0062
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0008 0.0005
Onchocerca volvulus 0.0023 0.0029 0.0048
Trypanosoma brucei RNA helicase, putative 0.023 0.0724 0.6459
Mycobacterium ulcerans aldehyde dehydrogenase 0.0255 0.0806 0.3127
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0068 0.0133
Brugia malayi hypothetical protein 0.0102 0.0295 0.0577
Echinococcus granulosus geminin 0.0541 0.1763 0.1761
Loa Loa (eye worm) hypothetical protein 0.0693 0.2273 0.4458
Brugia malayi jmjC domain containing protein 0.006 0.0151 0.0295
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0122 0.036 0.1347
Schistosoma mansoni hypothetical protein 0.006 0.0152 0.0152
Echinococcus granulosus enteropeptidase 0.0022 0.0026 0.0024
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0053 0.0474
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0049 0.0115 0.0225
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0091
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0094 0.0267 0.6824
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0091
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0017 0.0017
Brugia malayi hypothetical protein 0.0042 0.0092 0.0178
Giardia lamblia Kinase, CMGC MAPK 0.0115 0.0338 0.0642
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0284 0.2519
Mycobacterium ulcerans DNA polymerase IV 0.0099 0.0284 0.1044
Trypanosoma brucei ingi protein (ORF1) 0.0028 0.0046 0.0392
Mycobacterium tuberculosis Hypothetical protein 0.0053 0.013 0.0432
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0107 0.0957
Loa Loa (eye worm) hypothetical protein 0.0058 0.0147 0.0289
Trypanosoma brucei cytochrome P450, putative 0.003 0.0053 0.0449
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0118 0.0346 0.0677
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0369 0.0724
Schistosoma mansoni RAR-like nuclear receptor 0.0049 0.0115 0.0115
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0031 0.0028
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0118 0.0346 0.0678
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.0284 0.2537
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0322 0.055
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0026 0.0026
Echinococcus multilocularis expressed protein 0.0033 0.0062 0.0059
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0029 0.0026
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.006 0.0509
Onchocerca volvulus 0.0693 0.2273 0.3912
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0103 0.1277
Loa Loa (eye worm) hypothetical protein 0.0049 0.0115 0.0226
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.013 0.0254
Echinococcus granulosus transcription factor btf3 0.0111 0.0322 0.032
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.002 0.004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0057
Echinococcus multilocularis receptor type guanylyl cyclase 0.0028 0.0046 0.0044
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0118 0.0346 0.9526
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.002 0.0018
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0049 0.0115 0.0113
Brugia malayi nuclear receptor NHR-88 0.0023 0.0029 0.0055
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1537 0.51 1
Schistosoma mansoni aldehyde dehydrogenase 0.0255 0.0806 0.0806
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0028 0.0223
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0123 0.0363 0.0363
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0049 0.0115 0.0226
Brugia malayi hypothetical protein 0.0028 0.0046 0.0088
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0016 0.0022
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0049 0.0115 0.0226
Leishmania major extracellular receptor, putative 0.0028 0.0046 0.039
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0123 0.0363 0.0361
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.001
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0017 0.0014
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0014 0.0027
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0046 0.0084
Echinococcus granulosus GPCR family 2 0.0073 0.0196 0.0193
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0084 0.0156
Echinococcus multilocularis pyruvate kinase 0.0018 0.0011 0.0009
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0068 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0338 0.0338
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0038 0.006
Loa Loa (eye worm) hypothetical protein 0.008 0.022 0.0431
Schistosoma mansoni metabotropic glutamate receptor 0.0044 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0057
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.0609 0.0606
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0284 0.2519
Brugia malayi ImpB/MucB/SamB family protein 0.0073 0.0196 0.0383
Leishmania major basic transcription factor 3a, putative 0.0111 0.0322 0.2864
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0046 0.0105 0.033
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0026 0.0026
Echinococcus multilocularis pyruvate kinase 0.0035 0.0068 0.0065
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0074 0.02 0.0708
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0017 0.0014
Echinococcus granulosus lamin 0.0058 0.0147 0.0144
Trypanosoma brucei protein kinase, putative 0.0115 0.0338 0.3005
Chlamydia trachomatis glutamine binding protein 0.0122 0.036 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0046 0.0107 0.0935
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0103 0.0173
Echinococcus multilocularis sodium and chloride dependent glycine 0.0118 0.0346 0.0343
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0033 0.0063
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0017 0.0031
Plasmodium falciparum flap endonuclease 1 0.003 0.0053 0.1011
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0049 0.0115 0.0113
Echinococcus multilocularis geminin 0.0541 0.1763 0.1761
Loa Loa (eye worm) latrophilin receptor protein 2 0.0073 0.0196 0.0384
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0028 0.0223
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.0505 0.1928
Echinococcus multilocularis zinc finger protein 0.0024 0.0031 0.0028
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0015 0.0003 0.0003
Schistosoma mansoni protein kinase 0.0028 0.0046 0.0046
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0115 0.0338 0.3022
Trichomonas vaginalis DNA helicase recq, putative 0.0037 0.0074 0.0123
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0028 0.0247
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0046 0.0575
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0057
Brugia malayi hypothetical protein 0.0019 0.0017 0.0031
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0112 0.0109
Brugia malayi Guanylyl cyclase protein 23 0.0028 0.0046 0.0089
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0339 0.1088 0.4254
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0057
Trypanosoma brucei ribonuclease H1 0.0023 0.0029 0.0235
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0075 0.0202 0.02
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0038 0.006
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.0394 0.3518
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0073 0.0196 0.0193
Loa Loa (eye worm) hypothetical protein 0.0157 0.0479 0.0939
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.022 0.0429
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0118 0.0346 0.0343
Schistosoma mansoni hypothetical protein 0.0073 0.0196 0.0196
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.0284 0.2537
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0037 0.0074 0.0663
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0059 0.0148 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.0115 0.0225
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0026 0.0026
Onchocerca volvulus 0.0022 0.0026 0.0044
Onchocerca volvulus 0.0112 0.0327 0.0562
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0022 0.0026 0.0024
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.022 0.0788
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.01 0.089
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0053 0.0096
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0118 0.0346 0.0346
Echinococcus granulosus thymidylate synthase 0.0112 0.0327 0.0325
Trypanosoma cruzi transcription factor btf3, putative 0.0111 0.0322 0.2882
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0168 0.0168
Schistosoma mansoni SET domain protein 0.0015 0.0001 0.0001
Brugia malayi Trypsin family protein 0.0022 0.0026 0.005
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0049 0.0115 0.0225
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0008
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0046 0.0044
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0348 0.1119 0.4376
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0017 0.0033
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0022 0.0026 0.0024
Giardia lamblia NADH oxidase lateral transfer candidate 0.0046 0.0107 0.02
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0015 0.0003 0.0024
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0017 0.0031
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0046 0.0107 0.4574
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0348 0.1119 1
Echinococcus multilocularis glutamate receptor 2 0.0081 0.0223 0.022
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0112 0.0109
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0115 0.0338 0.3022
Loa Loa (eye worm) hypothetical protein 0.023 0.0723 0.1417
Loa Loa (eye worm) solute carrier family 6 member 4 0.0693 0.2273 0.4458
Trypanosoma cruzi extracellular receptor, putative 0.0028 0.0046 0.0414
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0026 0.0026
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0046 0.0091
Trypanosoma brucei DNA polymerase IV, putative 0.0099 0.0284 0.2519
Schistosoma mansoni ap endonuclease 0.0039 0.0081 0.0081
Loa Loa (eye worm) pigment dispersing factor receptor c 0.023 0.0723 0.1417
Schistosoma mansoni hypothetical protein 0.0073 0.0196 0.0196
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0158 0.048 0.4281
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0017 0.0033
Loa Loa (eye worm) hypothetical protein 0.0049 0.0115 0.0226
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0038 0.006
Trichomonas vaginalis mercuric reductase, putative 0.0046 0.0107 0.018
Trichomonas vaginalis rotamase, putative 0.0033 0.0062 0.0102
Onchocerca volvulus Bile acid receptor homolog 0.0049 0.0115 0.0197
Schistosoma mansoni glutamate receptor kainate 0.0081 0.0223 0.0223
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0017 0.0014
Brugia malayi POT family protein 0.0096 0.0274 0.0536
Schistosoma mansoni glutamate receptor kainate 0.0081 0.0223 0.0223
Schistosoma mansoni glutamate receptor NMDA 0.0081 0.0223 0.0223
Echinococcus multilocularis nmda type glutamate receptor 0.0028 0.0046 0.0044
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.01 0.089
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0263 0.0833 0.1633
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0027 0.0024
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0123 0.0363 0.0361
Schistosoma mansoni zinc finger protein 0.0024 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0075
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0118 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0052
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0031 0.0031
Treponema pallidum sodium- and chloride- dependent transporter 0.0693 0.2273 0.4351
Onchocerca volvulus 0.0028 0.0046 0.0078
Entamoeba histolytica hypothetical protein 0.0042 0.0092 0.0175
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.045 0.045
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0081 0.0159
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.045 0.088
Schistosoma mansoni cpg binding protein 0.0067 0.0177 0.0177
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0015 0.0003 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0017 0.0024
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0026 0.0026
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0132 0.0394 0.0391
Loa Loa (eye worm) hypothetical protein 0.0236 0.0742 0.1455
Chlamydia trachomatis endonuclease IV 0.008 0.022 0.52
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0284 0.2519
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0049 0.0115 0.0115
Brugia malayi Steroid receptor seven-up type 2 0.0049 0.0115 0.0225
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0046 0.0107 0.2148
Brugia malayi hypothetical protein 0.0053 0.013 0.0254
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0053 0.0472
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0115 0.0338 0.3005
Mycobacterium ulcerans hypothetical protein 0.0022 0.0026 0.0016
Plasmodium falciparum basic transcription factor 3b, putative 0.0111 0.0322 0.6676
Loa Loa (eye worm) nuclear hormone receptor 0.0023 0.0029 0.0057
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0031 0.0028
Schistosoma mansoni lamin 0.0058 0.0147 0.0147
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0017 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0115 0.101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0033
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0023 0.0029 0.0026
Schistosoma mansoni lipoxygenase 0.0099 0.0284 0.0284
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0132 0.0394 0.0772
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0112 0.0112
Trypanosoma brucei unspecified product 0.0028 0.0046 0.0392
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0338 0.0577
Trypanosoma brucei ingi protein (ORF1) 0.0028 0.0046 0.0392
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0068 0.0116
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0026 0.0026
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0029 0.0049 0.0613
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0057
Schistosoma mansoni lamin 0.0058 0.0147 0.0147
Onchocerca volvulus 0.0263 0.0833 0.1433
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0092 0.0092
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0046 0.0105 0.033
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0369 0.0724
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0115 0.0113
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0044
Brugia malayi hypothetical protein 0.0026 0.0038 0.0073
Loa Loa (eye worm) glutamate receptor 2 0.0081 0.0223 0.0438
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0132 0.0394 0.0394
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0222 0.0694 0.0694
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0134 0.0131
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0038 0.006
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0028 0.0046 0.0392
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0049 0.0115 0.0113
Brugia malayi ecdysteroid receptor 0.0049 0.0115 0.0225
Echinococcus granulosus FTZ F1 alpha 0.0049 0.0115 0.0113
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0122 0.036 0.0689
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0132 0.0394 0.3503
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0008
Plasmodium vivax thioredoxin reductase, putative 0.0134 0.04 0.5748
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0046 0.0575
Brugia malayi ecdysone receptor 0.0023 0.0029 0.0055
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0049 0.0115 0.0113
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0094 0.0267 0.0455
Echinococcus granulosus Solute carrier family 22 5 0.1191 0.3942 0.394
Giardia lamblia DINP protein human, muc B family 0.0079 0.0218 0.0412
Schistosoma mansoni hypothetical protein 0.0022 0.0026 0.0026
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0068 0.0112
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0046 0.0107 0.0935
Schistosoma mansoni ATP-binding cassette transporter 0.0081 0.0223 0.0223
Treponema pallidum NADH oxidase 0.0046 0.0107 0.0205
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0026 0.0026
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0046 0.0107 0.0339
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0118 0.0346 0.0343
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0022 0.0194
Onchocerca volvulus 0.0022 0.0026 0.0044
Loa Loa (eye worm) steroid hormone receptor 0.0049 0.0115 0.0226
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0046 0.0107 0.1329
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.0394 0.3518
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0073 0.0196 0.0382
Schistosoma mansoni hypothetical protein 0.0818 0.2693 0.2693
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.013 0.013
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0056 0.0111
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0026 0.0026
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0081 0.0236
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0075
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0168 0.0168
Onchocerca volvulus 0.0062 0.016 0.0274
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0027 0.0027
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0046 0.0043
Schistosoma mansoni flap endonuclease-1 0.0027 0.0043 0.0043
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0068 0.0607
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0079 0.0218 0.078
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0142 0.1248
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0074 0.02 0.0708
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0005 0.0044
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0046 0.0107 0.0339
Toxoplasma gondii ribonuclease HI protein 0.0023 0.0029 0.036
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0212 0.0662 0.066
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0046 0.0107 0.151
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0046 0.0107 0.1516
Brugia malayi 6-phosphofructokinase 0.0348 0.1119 0.2192
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0046 0.0107 0.1516
Echinococcus granulosus Mastin 0.0022 0.0026 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0236 0.0742 0.0742
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0057
Schistosoma mansoni hypothetical protein 0.0042 0.0092 0.0092
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0003 0.0024
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.019 0.0588 0.1152
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0117 0.0114
Entamoeba histolytica hypothetical protein 0.0028 0.0046 0.0089
Schistosoma mansoni loxhd1 0.0017 0.0007 0.0007
Echinococcus granulosus transcription factor Dp 1 0.0076 0.0208 0.0205
Schistosoma mansoni hypothetical protein 0.0298 0.0951 0.0951
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0029 0.0055
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0046 0.0107 0.0209
Echinococcus granulosus dna polymerase kappa 0.0099 0.0284 0.0281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0049 0.0115 0.0226
Plasmodium falciparum thioredoxin reductase 0.0134 0.04 0.8306
Echinococcus multilocularis mitogen activated protein kinase 3 0.0115 0.0338 0.0335
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0134 0.0131
Trichomonas vaginalis phosphofructokinase, putative 0.0348 0.1119 0.1921
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0023 0.0029 0.0026
Echinococcus granulosus dihydrofolate reductase 0.0046 0.0105 0.0102
Schistosoma mansoni DNA helicase recq5 0.0028 0.0046 0.0046
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0046 0.0105 0.1301
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0057
Loa Loa (eye worm) hypothetical protein 0.0049 0.0115 0.0226
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Schistosoma mansoni rab6-interacting 0.0017 0.0007 0.0007
Brugia malayi MH2 domain containing protein 0.0125 0.0369 0.0722
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.0394 0.3503
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0046 0.0107 0.0339
Brugia malayi hypothetical protein 0.0123 0.0364 0.0713
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0017 0.0014
Loa Loa (eye worm) glutaminase 2 0.0277 0.0878 0.1722
Loa Loa (eye worm) RGC/RGC protein kinase 0.0028 0.0046 0.0091
Onchocerca volvulus 0.0102 0.0295 0.0507
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0073 0.0196 0.0193
Echinococcus granulosus phd:f box containing protein 0.0016 0.0005 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0017 0.0024
Schistosoma mansoni hypothetical protein 0.0022 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0154
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0147 0.0287
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0005 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.018 0.0555 0.0553
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.006 0.0152 0.015
Loa Loa (eye worm) hypothetical protein 0.0102 0.0295 0.0578
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.006 0.0509
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0017 0.0014
Echinococcus granulosus glycoprotein Antigen 5 0.0022 0.0026 0.0024
Onchocerca volvulus 0.0017 0.0007 0.0011
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0028 0.0223
Loa Loa (eye worm) serotonin transporter b 0.0693 0.2273 0.4458
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0115 0.0338 0.3005
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0115 0.0338 0.4196
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0081 0.0135
Loa Loa (eye worm) hypothetical protein 0.0049 0.0115 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0049 0.0115 0.0225
Schistosoma mansoni nuclear receptor 0.0023 0.0029 0.0029
Schistosoma mansoni metabotropic glutamate receptor 0.0059 0.0148 0.0148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.013 0.0127
Brugia malayi jmjC domain containing protein 0.0065 0.0168 0.0329
Trichomonas vaginalis glutaminase, putative 0.0277 0.0878 0.1507
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0305 0.0974 0.3799
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0046 0.0044

Activities

Activity type Activity value Assay description Source Reference
Drug uptake (ADMET) = 32 % Drug accumulation in Saccharomyces cerevisiae AD12345678 reenergized with glucose at pH 6.0 assessed as intracellular accumulation after 60 mins by fluorescamine staining ChEMBL. 18794383
Drug uptake (ADMET) = 32 % Drug accumulation in Saccharomyces cerevisiae ADCDR1 expressing Candida albicans CDR1 efflux pump reenergized with glucose at pH 6.0 assessed as intracellular accumulation after 60 mins by fluorescamine staining ChEMBL. 18794383
Drug uptake (ADMET) = 32 % Drug accumulation in Saccharomyces cerevisiae ADCDR2 expressing Candida albicans CDR2 efflux pump reenergized with glucose at pH 6.0 after 60 mins by fluorescamine staining ChEMBL. 18794383
Drug uptake (ADMET) = 2.55 nmol/min Drug uptake in Saccharomyces cerevisiae AD12345678 at 200 uM pretreated for 10 mins measured after 60 mins by fluorescamine staining in presence of fluconazole ChEMBL. 18794383
Drug uptake (ADMET) = 2.58 nmol/min Drug uptake in Saccharomyces cerevisiae AD12345678 at 200 uM pretreated for 10 mins measured after 60 mins by fluorescamine staining ChEMBL. 18794383
Drug uptake (ADMET) = 2.59 nmol/min Drug uptake in Saccharomyces cerevisiae ADMDR1 expressing Candida albicans MDR1 efflux pump at 200 uM pretreated for 10 mins measured after 60 mins by fluorescamine staining ChEMBL. 18794383
Drug uptake (ADMET) = 2.61 nmol/min Drug uptake in Saccharomyces cerevisiae ADMDR1 at 200 uM pretreated for 10 mins measured after 60 mins by fluorescamine staining in presence of fluconazole ChEMBL. 18794383
Drug uptake (ADMET) = 3.94 nmol/min Drug uptake in Saccharomyces cerevisiae ADCDR2 at 200 uM pretreated for 10 mins measured after 60 mins by fluorescamine staining in presence of fluconazole ChEMBL. 18794383
Drug uptake (ADMET) = 4.08 nmol/min Drug uptake in Saccharomyces cerevisiae ADCDR2 expressing Candida albicans CDR2 efflux pump at 200 uM pretreated for 10 mins measured after 60 mins by fluorescamine staining ChEMBL. 18794383
Drug uptake (ADMET) = 4.2 nmol/min Drug uptake in Saccharomyces cerevisiae ADCDR1 at 200 uM pretreated for 10 mins measured after 60 mins by fluorescamine staining in presence of fluconazole ChEMBL. 18794383
Drug uptake (ADMET) = 4.46 nmol/min Drug uptake in Saccharomyces cerevisiae ADCDR1 expressing Candida albicans CDR1 efflux pump at 200 uM pretreated for 10 mins measured after 60 mins by fluorescamine staining ChEMBL. 18794383
EC50 (functional) = 0.08 mM Activation of human PEPT1 expressed in MDCK cells ChEMBL. 16759105
EC50 (functional) = 0.08 mM Activation of human PEPT1 expressed in MDCK cells ChEMBL. 16759105
IC50 (binding) = 3.21 Biological activity of the compound was measured against Angiotensin I converting enzyme ChEMBL. 7629809
IC50 (binding) = 6.6 M Inhibition of DAla-DAla Ligase at 10e -3 M of the compound ChEMBL. 2502630
IC50 (functional) = 0.25 mM Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells ChEMBL. 16759105
IC50 (functional) = 0.25 mM Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells ChEMBL. 16759105
IC50 (functional) = 63 uM TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 25000 uM) in PEPT1-expressing CHO cells ChEMBL. 8956326
Inhibition (functional) > 80 % TP_TRANSPORTER: inhibition of VACV uptake (VAVC: 20 uM, Ala-Ala: 10000 uM) in PEPT1-expressing CHO cells ChEMBL. 10087037
KA (binding) = 50 uM Tested in vitro for activation of Human cloned isozyme carbonic anhydrase I (hCA I) ChEMBL. 11934582
KA (binding) = 50 uM Tested in vitro for activation of Human cloned isozyme carbonic anhydrase I (hCA I) ChEMBL. 11934582
KA (binding) = 62 uM Tested in vitro for activation of carbonic anhydrase IV (bCA IV), purified from bovine lung microsomes ChEMBL. 11934582
KA (binding) = 62 uM Tested in vitro for activation of carbonic anhydrase IV (bCA IV), purified from bovine lung microsomes ChEMBL. 11934582
KA (binding) = 110 uM Tested in vitro for activation of Human cloned isozyme carbonic anhydrase II (hCA II) ChEMBL. 11934582
KA (binding) = 110 uM Tested in vitro for activation of Human cloned isozyme carbonic anhydrase II (hCA II) ChEMBL. 11934582
Ki (ADMET) = 2.22 Binding affinity to human PepT2 in SKTP cells ChEMBL. 21741846
Ki (ADMET) = 0.006 mM Binding affinity to human PepT2 in SKTP cells ChEMBL. 21741846
Ki (binding) = 0.14 mM Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells ChEMBL. 15974593
Ki (binding) = 2.1 mM Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells ChEMBL. 15974593
Ki (binding) = 0.14 nM Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells ChEMBL. 15974593
Ki (binding) = 2.1 nM Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells ChEMBL. 15974593
Ki (functional) = 6 uM TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing HeLa cells ChEMBL. 7495840
Ki (functional) = 78 uM TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT1-expressing HeLa cells ChEMBL. 7495840
Log 1/IC50 (binding) = 3.21 Biological activity of the compound was measured against Angiotensin I converting enzyme ChEMBL. 7629809
max activation (functional) = 125 % Activation of human PEPT1 expressed in MDCK cells relative to Gly-Sar ChEMBL. 16759105
max activation (functional) = 125 % Activation of human PEPT1 expressed in MDCK cells relative to Gly-Sar ChEMBL. 16759105
Ratio (functional) = 1700 Ratio of %GSmax to EC50 for human PEPT1 activation ChEMBL. 16759105

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

9 literature references were collected for this gene.

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