Detailed information for compound 28930

Basic information

Technical information
  • TDR Targets ID: 28930
  • Name: 1H-indole-2-carboxylic acid
  • MW: 161.157 | Formula: C9H7NO2
  • H donors: 2 H acceptors: 2 LogP: 1.91 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cc2c([nH]1)cccc2
  • InChi: 1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12)
  • InChiKey: HCUARRIEZVDMPT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • indole-2-carboxylic acid
  • chloropyramine
  • 1477-50-5
  • SPECTRUM1502082
  • Oprea1_557882
  • AQ-776/40177767
  • AIDS-019634
  • AIDS019634
  • KBioGR_001304
  • Spectrum4_001042
  • DivK1c_006772
  • SBB003953
  • Spectrum5_001735
  • KBioSS_001965
  • Spectrum_001485
  • 2-Carboxyindole
  • 2-Indolecarboxylic acid
  • NSC16598
  • KBio1_001716
  • KBio2_001965
  • KBio2_004533
  • KBio2_007101
  • SPBio_000081
  • SpecPlus_000676
  • 1H-Indole-2-carboxylic acid (9CI)
  • EINECS 216-030-4
  • NSC 16598
  • Spectrum3_000943
  • KBio3_002006
  • I5109_ALDRICH
  • NCGC00094957-01
  • SDCCGMLS-0065971.P001
  • NCGC00094957-02
  • Spectrum2_000021

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Sus scrofa D-amino-acid oxidase Starlite/ChEMBL References
Homo sapiens D-aspartate oxidase Starlite/ChEMBL References
Homo sapiens steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) Starlite/ChEMBL References
Hepatitis C virus Hepatitis C virus NS3 protease/helicase Starlite/ChEMBL References
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens D-amino-acid oxidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans putative d-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
Plasmodium vivax RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Theileria parva RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni d-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
Entamoeba histolytica DEAD/DEAH box helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Babesia bovis eukaryotic translation initiation factor 4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Leishmania mexicana 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Trypanosoma congolense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Onchocerca volvulus Eukaryotic initiation factor 4A homolog Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Trypanosoma brucei gambiense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Entamoeba histolytica steroid 5-alpha reductase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Leishmania donovani Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei gambiense 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative Get druggable targets OG5_128852 All targets in OG5_128852
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium berghei eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Cryptosporidium hominis eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Brugia malayi eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Leishmania braziliensis eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127583 All targets in OG5_127583
Giardia lamblia Translation initiation factor eIF-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Treponema pallidum ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Mycobacterium ulcerans D-amino acid oxidase Aao Get druggable targets OG5_127583 All targets in OG5_127583
Schistosoma japonicum Eukaryotic initiation factor 4A-II, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium knowlesi eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium yoelii RNA helicase-1 Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Neospora caninum DEAD-box ATP-dependent RNA helicase 34 (EC 3.6.1.-), related Get druggable targets OG5_126984 All targets in OG5_126984
Cryptosporidium parvum eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans D-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
Schistosoma japonicum ATP-dependent RNA helicase eIF4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum ko:K00272 D-aspartate oxidase [EC1.4.3.1], putative Get druggable targets OG5_127583 All targets in OG5_127583
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania braziliensis 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao Get druggable targets OG5_127583 All targets in OG5_127583
Leishmania donovani 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum Eukaryotic initiation factor 4A-III, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium falciparum eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Get druggable targets OG5_128852 All targets in OG5_128852
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_128852 All targets in OG5_128852
Echinococcus granulosus eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative Get druggable targets OG5_128852 All targets in OG5_128852
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128852 All targets in OG5_128852
Leishmania mexicana Get druggable targets OG5_126984 All targets in OG5_126984
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO Get druggable targets OG5_127583 All targets in OG5_127583
Candida albicans putative d-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
Candida albicans D-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
Toxoplasma gondii eukaryotic initiation factor-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase Get druggable targets OG5_128852 All targets in OG5_128852
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans D-amino acid oxidase Aao D-aspartate oxidase 369 aa 373 aa 28.7 %
Onchocerca volvulus Unconventional prefoldin RPB5 interactor 1 homolog D-amino-acid oxidase   347 aa 351 aa 30.8 %
Mycobacterium ulcerans D-amino acid oxidase Aao D-amino-acid oxidase 347 aa 378 aa 24.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Candida albicans similar to putative d-amino acid oxidase D-amino-acid oxidase   347 aa 390 aa 23.3 %
Brugia malayi Synaptic glycoprotein SC2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 254 aa 208 aa 28.9 %
Mycobacterium ulcerans D-amino acid oxidase Aao D-amino-acid oxidase   347 aa 376 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0089 0.0093
Schistosoma mansoni coup transcription factor 0.001 0.0009 0.0009
Schistosoma mansoni nAChR subunit 0.0041 0.0373 0.0389
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.001 0.0009 0.0009
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0164 0.1803 0.1879
Schistosoma mansoni cpg binding protein 0.0032 0.0265 0.0276
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0049 0.046 1
Schistosoma mansoni protein kinase C alpha binding protein 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0236 0.035
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0049 0.046 0.0766
Echinococcus multilocularis PKC activated phosphatase 1 inhibitor 0.0143 0.1553 0.1552
Treponema pallidum ATP-dependent RNA helicase 0.003 0.0236 0.5
Brugia malayi hypothetical protein 0.0041 0.0373 0.0621
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0244 0.0242
Onchocerca volvulus 0.0033 0.0272 0.0451
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0009 0.0007
Schistosoma mansoni neurotransmitter gated ion channel 0.0041 0.0373 0.0389
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 0.2089 1
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0584 0.6696 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0076 0.0077
Brugia malayi Hypothetical 13.5 kDa protein C45G9.7 in chromosome III 0.001 0.0009 0.0012
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0049 0.046 0.0766
Schistosoma mansoni hypothetical protein 0.0096 0.1015 0.1058
Echinococcus granulosus PKC activated phosphatase 1 inhibitor 0.0143 0.1553 0.1617
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0412 0.043
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0027 0.0201 0.0656
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0009 0.0012
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0089 0.0934 0.0972
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0089 0.0934 0.1392
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0441 0.046
Onchocerca volvulus 0.001 0.0009 0.0012
Plasmodium vivax SET domain protein, putative 0.003 0.0244 0.1982
Echinococcus multilocularis Na(+):H(+) exchange regulatory cofactor NHE RF2 0.001 0.0009 0.0007
Echinococcus multilocularis lamin dm0 0.0033 0.0272 0.027
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0771 0.8868 0.8868
Schistosoma mansoni nAChR subunit 0.0089 0.0934 0.0973
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0009 0.001
Schistosoma mansoni multiple pdz domain protein 0.001 0.0009 0.0009
Loa Loa (eye worm) acetylcholine receptor protein 0.0041 0.0373 0.0554
Echinococcus granulosus glycine receptor subunit beta 0.0089 0.0934 0.0972
Brugia malayi Sex muscle abnormal protein 5 0.0013 0.0043 0.0069
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Schistosoma mansoni fad oxidoreductase 0.0049 0.046 0.0479
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0089 0.0934 0.0972
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0027 0.0201 0.0056
Schistosoma mansoni syntrophin 0.001 0.0009 0.0009
Brugia malayi steroid hormone receptor 0.001 0.0009 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.1015 0.1696
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0049 0.046 0.0477
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0049 0.046 0.1934
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.001 0.0009 0.001
Schistosoma mansoni protein kinase 0.0771 0.8868 0.9243
Schistosoma mansoni lim domain 0.001 0.0014 0.0014
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0272 0.0403
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0009 0.0007
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0412 0.0428
Echinococcus granulosus glycine receptor subunit alpha 1 0.0089 0.0934 0.0972
Echinococcus granulosus multiple pdz domain protein 0.001 0.0009 0.0007
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0041 0.0373 0.0387
Brugia malayi RasGEF domain containing protein 0.001 0.0009 0.0012
Brugia malayi mbt repeat family protein 0.0047 0.0443 0.0738
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0089 0.0934 0.0932
Echinococcus multilocularis rho guanine nucleotide exchange factor 12 0.001 0.0009 0.0007
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0041 0.0373 0.0621
Mycobacterium ulcerans hypothetical protein 0.0189 0.2089 0.2613
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0209 0.2322 0.232
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0049 0.046 0.0766
Entamoeba histolytica hypothetical protein 0.0072 0.0728 0.348
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0041 0.0373 0.0621
Brugia malayi PDZ domain containing protein 0.001 0.0009 0.0012
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0523 0.5977 0.5977
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0089 0.0934 0.156
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Onchocerca volvulus 0.001 0.0009 0.0012
Echinococcus multilocularis Partitioning defective 3 protein B 0.001 0.0009 0.0007
Echinococcus granulosus MAGUK p55 subfamily 0.001 0.0009 0.0007
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.001 0.0009 0.0009
Loa Loa (eye worm) gopc protein 0.001 0.0009 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0009 0.0011
Echinococcus granulosus glutamate receptor interacting protein 1 0.001 0.0009 0.0007
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0519 0.0539
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Schistosoma mansoni hypothetical protein 0.0011 0.0026 0.0027
Echinococcus multilocularis partitioning defective 3 0.001 0.0009 0.0007
Schistosoma mansoni maguk P55 subfamily member 26 0.001 0.0009 0.0009
Echinococcus multilocularis nAChR subunit 0.0089 0.0934 0.0932
Brugia malayi syntenin 0.001 0.0009 0.0012
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0096 0.014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0728 0.0726
Echinococcus granulosus Partitioning defective 3 protein B 0.001 0.0009 0.0007
Schistosoma mansoni protein kinase 0.0771 0.8868 0.9243
Echinococcus multilocularis tyrosine protein kinase shark 0.0009 0.0002 0.000000014431
Schistosoma mansoni neurotransmitter gated ion channel 0.0041 0.0373 0.0389
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0009 0.0009
Brugia malayi excitatory GABA receptor EXP-1A 0.0089 0.0934 0.156
Plasmodium falciparum polyprenol reductase, putative 0.0027 0.0201 0.0392
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0009 0.0012
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0244 0.0281
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0009 0.0012
Brugia malayi Pre-SET motif family protein 0.0207 0.2301 0.3848
Echinococcus multilocularis GPCR, family 2 0.0096 0.1015 0.1013
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.1015 0.1013
Loa Loa (eye worm) hypothetical protein 0.0038 0.0335 0.0498
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0728 0.0757
Echinococcus granulosus cell polarity protein 0.001 0.0009 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0009 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0009 0.0011
Echinococcus multilocularis pdz domain containing protein 0.001 0.0009 0.0007
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0009 0.0011
Brugia malayi CXXC zinc finger family protein 0.0028 0.0224 0.0371
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0016 0.0076 0.0074
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.003 0.0236 0.0246
Brugia malayi Variant SH3 domain containing protein 0.0013 0.0043 0.0069
Brugia malayi Partitioning defective-6 homolog alpha 0.001 0.0009 0.0012
Echinococcus granulosus cpg binding protein 0.0032 0.0265 0.0274
Loa Loa (eye worm) hypothetical protein 0.0049 0.046 0.0684
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0048 0.0453 0.0473
Brugia malayi Peripheral plasma membrane protein CASK 0.0016 0.0083 0.0136
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0049 0.046 0.1934
Schistosoma mansoni tyrosine kinase 0.0016 0.0076 0.0079
Schistosoma mansoni sh3 and multiple ankyrin repeat domains protein 12 (shank12) 0.001 0.0009 0.0009
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0236 0.0143
Schistosoma mansoni tyrosine kinase 0.0202 0.2246 0.2341
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0041 0.0373 0.0387
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0049 0.046 0.0684
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0519 0.0865
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0009 0.0012
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.06 0.0624
Loa Loa (eye worm) 9ORF binding protein 1 0.001 0.0009 0.001
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.001 0.0009 0.0007
Echinococcus multilocularis nAChR subunit 0.0048 0.0453 0.0452
Schistosoma mansoni regulator of G protein signaling 0.001 0.0009 0.0009
Loa Loa (eye worm) GABA receptor subunit 0.0048 0.0453 0.0675
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0443 0.0462
Schistosoma mansoni cell polarity protein 0.001 0.0009 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0009 0.0012
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0089 0.0934 0.156
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0009 0.0012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0009 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.2109 0.2198
Schistosoma mansoni nck2/grb4 0.0013 0.0043 0.0045
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.001 0.0009 0.0007
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0089 0.0934 0.0972
Brugia malayi PDZ-domain protein scribble 0.001 0.0009 0.0012
Leishmania major hypothetical protein, conserved 0.0049 0.046 0.1934
Brugia malayi nuclear hormone receptor 0.001 0.0009 0.0012
Schistosoma mansoni nAChR subunit 0.0089 0.0934 0.0973
Leishmania major hypothetical protein, conserved 0.0026 0.0191 0.0603
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0412 0.0867
Onchocerca volvulus 0.001 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0009 0.0012
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0016 0.0076 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0009 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0009 0.0009
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.001 0.0009 0.0007
Echinococcus granulosus lamin 0.0033 0.0272 0.0281
Schistosoma mansoni dishevelled 0.001 0.0009 0.0009
Schistosoma mansoni nuclear hormone receptor 0.001 0.0009 0.0009
Onchocerca volvulus 0.0047 0.0443 0.0738
Echinococcus granulosus MAGUK p55 subfamily 0.001 0.0009 0.0007
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0089 0.0934 0.156
Trichomonas vaginalis set domain proteins, putative 0.0235 0.2633 1
Schistosoma mansoni hypothetical protein 0.002 0.013 0.0136
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0089 0.0934 0.0973
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Schistosoma mansoni hypothetical protein 0.0096 0.1015 0.1058
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1238 0.1847
Schistosoma mansoni pdz domain containing protein 0.001 0.0009 0.0009
Echinococcus granulosus multiple pdz domain protein 0.001 0.0009 0.0007
Entamoeba histolytica hypothetical protein 0.0027 0.0201 0.0956
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.001 0.0014 0.0012
Leishmania major eukaryotic initiation factor 4a, putative 0.003 0.0236 0.0828
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0011
Schistosoma mansoni tyrosine kinase 0.0016 0.0076 0.0079
Brugia malayi PX domain containing protein 0.001 0.0009 0.0012
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0443 0.046
Brugia malayi hypothetical protein 0.001 0.0009 0.0012
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.001 0.0009 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0009 0.0012
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0089 0.0934 0.0972
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0027 0.0201 0.0392
Brugia malayi PDZ domain 0.001 0.0009 0.0012
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0016 0.0076 0.0074
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0041 0.0373 0.0371
Echinococcus multilocularis amyloid beta A4 protein 0.001 0.0009 0.0007
Onchocerca volvulus 0.0048 0.0453 0.0756
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0009 0.0007
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0027 0.0201 0.021
Brugia malayi Neurabin protein 1 0.001 0.0009 0.0012
Echinococcus multilocularis 0.001 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1238 0.1847
Schistosoma mansoni Patj homolog 0.001 0.0009 0.0009
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.2061 0.2147
Schistosoma mansoni nAChR subunit 0.0089 0.0934 0.0973
Brugia malayi Syntrophin-1 0.001 0.0009 0.0012
Echinococcus granulosus tyrosine protein kinase shark 0.0009 0.0002 0.000000015041
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0519 0.0541
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0089 0.0934 0.156
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0412 0.0687
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0536 0.6129 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0089 0.0934 0.156
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0048 0.0453 0.0473
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0244 0.0254
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0011
Entamoeba histolytica hypothetical protein 0.0072 0.0728 0.348
Echinococcus granulosus eukaryotic initiation factor 4A III 0.003 0.0236 0.0244
Brugia malayi PDZ domain containing protein 0.001 0.0009 0.0012
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0011 0.002 0.0018
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0412 0.0867
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Schistosoma mansoni multiple pdz domain protein 0.001 0.0009 0.0009
Schistosoma mansoni tight junction protein 0.001 0.0009 0.0009
Schistosoma mansoni adapter molecule crk 0.0013 0.0043 0.0045
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.001 0.0014 0.0012
Schistosoma mansoni hypothetical protein 0.0208 0.2318 0.2416
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0412 0.1966
Schistosoma mansoni cell polarity protein 0.001 0.0009 0.0009
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0089 0.0934 0.156
Echinococcus granulosus glycine receptor subunit alpha 1 0.0089 0.0934 0.0972
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.003 0.0236 0.0239
Echinococcus granulosus zinc finger protein 0.0021 0.0137 0.0141
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0027 0.0201 0.0392
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.2109 0.2198
Schistosoma mansoni multiple pdz domain protein 0.001 0.0009 0.0009
Brugia malayi nuclear receptor NHR-88 0.001 0.0009 0.0012
Echinococcus granulosus syndecan binding protein syntenin 0.001 0.0009 0.0007
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0075 0.0077
Brugia malayi Protein-tyrosine phosphatase 1 0.001 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0009 0.0012
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.001 0.0009 0.0007
Onchocerca volvulus 0.001 0.0009 0.0012
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0009 0.0012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0009 0.0007
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0028 0.0044
Brugia malayi Cation transporter family protein 0.0089 0.0934 0.156
Loa Loa (eye worm) hypothetical protein 0.0584 0.6696 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0009 0.0012
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0089 0.0934 0.156
Schistosoma mansoni ATP-dependent RNA Helicase 0.001 0.0009 0.0009
Echinococcus multilocularis geminin 0.0345 0.3903 0.3902
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0009 0.0009
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0048 0.0453 0.0756
Brugia malayi Cation transporter family protein 0.0089 0.0934 0.156
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Loa Loa (eye worm) ACC-1 protein 0.0089 0.0934 0.1392
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.011
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.001 0.0009 0.0007
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0189 0.2089 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0089 0.0934 0.156
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Schistosoma mansoni acetylcholine receptor subunit beta 0.0041 0.0373 0.0389
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.5228 0.5449
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0412 0.17
Schistosoma mansoni hypothetical protein 0.0015 0.0069 0.0072
Brugia malayi hypothetical protein 0.001 0.0009 0.0012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0009 0.0009
Echinococcus multilocularis musashi 0.0033 0.0272 0.027
Echinococcus granulosus partitioning defective 3 0.001 0.0009 0.0007
Schistosoma mansoni growth factor receptor-bound protein 0.0013 0.0043 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Echinococcus multilocularis syndecan binding protein (syntenin) 0.001 0.0009 0.0007
Schistosoma mansoni sap-97 0.001 0.0009 0.0009
Echinococcus granulosus beta 1 syntrophin 0.001 0.0009 0.0007
Echinococcus multilocularis glutamate receptor interacting protein 1 0.001 0.0009 0.0007
Brugia malayi Guanylate kinase family protein 0.0016 0.0083 0.0136
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0009 0.0007
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0049 0.046 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0412 0.0428
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0089 0.0934 0.0932
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0412 0.041
Schistosoma mansoni discs large 0.001 0.0009 0.0009
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0191 0.0603
Brugia malayi PDZ domain containing protein 0.001 0.0009 0.0012
Leishmania major hypothetical protein, conserved 0.0049 0.046 0.1934
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0027 0.0201 0.0656
Echinococcus granulosus pdz domain containing protein 0.001 0.0009 0.0007
Schistosoma mansoni nAChR subunit 0.0089 0.0934 0.0973
Echinococcus granulosus pdz domain containing protein 0.001 0.0009 0.0007
Loa Loa (eye worm) RasGEF domain-containing protein 0.001 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0009 0.0007
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0189 0.2089 0.3493
Schistosoma mansoni nAChR subunit 0.0041 0.0373 0.0389
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 0.2089 0.7764
Brugia malayi eukaryotic initiation factor 4A 0.003 0.0236 0.0392
Loa Loa (eye worm) ACC-1 protein 0.0089 0.0934 0.1392
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0049 0.046 0.1934
Schistosoma mansoni maguk P55 subfamily member 35 0.001 0.0009 0.0009
Echinococcus multilocularis disks large 3 0.001 0.0009 0.0007
Onchocerca volvulus 0.0089 0.0934 0.156
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0171 0.017
Brugia malayi hypothetical protein 0.0072 0.0728 0.1215
Schistosoma mansoni bromodomain containing protein 0.0064 0.0641 0.0669
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0608 0.0634
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Schistosoma mansoni lamin 0.0033 0.0272 0.0283
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0016 0.0076 0.0079
Echinococcus granulosus ligand of numb protein x 2 0.001 0.0009 0.0007
Schistosoma mansoni pdz and lim domain protein 0.001 0.0014 0.0014
Loa Loa (eye worm) syntrophin-1 0.001 0.0009 0.001
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0519 0.0517
Echinococcus multilocularis c src tyrosine kinase 0.0016 0.0076 0.0074
Echinococcus granulosus tyrosine protein kinase Src64B 0.0016 0.0076 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0009 0.0012
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0048 0.0453 0.0756
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.001 0.0009 0.0007
Brugia malayi RE18450p 0.0049 0.046 0.0766
Echinococcus multilocularis cpg binding protein 0.0032 0.0265 0.0263
Onchocerca volvulus 0.0041 0.0373 0.0621
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0076 0.0077
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.001 0.0014 0.0012
Echinococcus multilocularis MAGUK p55 subfamily 0.001 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.5228 0.5227
Echinococcus granulosus nAChR subunit 0.0089 0.0934 0.0972
Schistosoma mansoni cell polarity protein 0.001 0.0009 0.0009
Schistosoma mansoni nAChR subunit 0.0089 0.0934 0.0973
Entamoeba histolytica hypothetical protein 0.0072 0.0728 0.348
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0523 0.5977 0.623
Schistosoma mansoni cell polarity protein 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Echinococcus granulosus geminin 0.0345 0.3903 0.4067
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0224 0.0331
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.2061 0.206
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 0.2089 0.7764
Echinococcus granulosus growth factor receptor bound protein 2 0.0013 0.0043 0.0043
Onchocerca volvulus 0.001 0.0009 0.0012
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0049 0.046 0.0379
Loa Loa (eye worm) hypothetical protein 0.0164 0.1803 0.269
Brugia malayi mbt repeat family protein 0.0047 0.0443 0.0738
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.1015 0.1056
Schistosoma mansoni neurotransmitter gated ion channel 0.0048 0.0453 0.0473
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0412 0.817
Brugia malayi intermediate filament protein 0.0033 0.0272 0.0451
Loa Loa (eye worm) PDZ domain-containing protein 0.001 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0453 0.0675
Loa Loa (eye worm) hypothetical protein 0.0033 0.0272 0.0403
Loa Loa (eye worm) LGC-31 protein 0.0089 0.0934 0.1392
Loa Loa (eye worm) hypothetical protein 0.004 0.0362 0.0539
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0089 0.0934 0.1392
Echinococcus multilocularis myeloid:lymphoid or mixed lineage leukemia 0.001 0.0009 0.0007
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0089 0.0934 0.0972
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0099
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.001 0.0009 0.0007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2301 0.3435
Echinococcus granulosus glycine receptor subunit beta 0.0089 0.0934 0.0972
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.001 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0027 0.0201 0.021
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0009 0.0011
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0049 0.046 0.2193
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0412 0.041
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0049 0.046 0.2193
Brugia malayi Abnormal embryonic partitioning of cytoplasm protein 3 0.001 0.0009 0.0012
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.1015 0.1513
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0171 0.0177
Brugia malayi Shank2E 0.001 0.0009 0.0012
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0009 0.0009
Onchocerca volvulus Putative nachr subunit 0.0523 0.5977 1
Schistosoma mansoni nAChR subunit 0.0089 0.0934 0.0973
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Brugia malayi ecdysteroid receptor 0.001 0.0009 0.0012
Brugia malayi hypothetical protein 0.001 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0011
Brugia malayi microtubule-associated serine/threonine protein kinase 2 (MAST2) 0.001 0.0009 0.0012
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Loa Loa (eye worm) PX domain-containing protein 0.001 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Echinococcus multilocularis microtubule associated serine:threonine protein 0.0011 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Schistosoma mansoni tyrosine kinase 0.0016 0.0076 0.0079
Brugia malayi Variant SH3 domain containing protein 0.0013 0.0043 0.0069
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0041 0.0373 0.0371
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Brugia malayi Guanylate kinase family protein 0.001 0.0009 0.0012
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 0.2089 0.7764
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Schistosoma mansoni hypothetical protein 0.0287 0.3238 0.3375
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0027 0.0201 0.0956
Brugia malayi Tyrosine-protein kinase abl-1 0.0123 0.1325 0.2215
Brugia malayi Tyrosine-protein kinase abl-1 0.0092 0.0963 0.1609
Echinococcus multilocularis cell polarity protein leucine rich repeat 0.001 0.0009 0.0007
Echinococcus multilocularis tyrosine protein kinase Abl 0.0092 0.0963 0.0962
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.2109 0.2107
Onchocerca volvulus 0.0048 0.0453 0.0756
Schistosoma mansoni protein phosphatase 1 inhibitor potentiated by protein kinase C 0.0143 0.1553 0.1619
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0009 0.0009
Chlamydia trachomatis D-amino acid dehydrogenase 0.0049 0.046 1
Giardia lamblia Translation initiation factor eIF-4A, putative 0.003 0.0236 0.1351
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Schistosoma mansoni intermediate filament proteins 0.0033 0.0272 0.0283
Brugia malayi hypothetical protein 0.0041 0.0373 0.0621
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.06 0.0598
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0189 0.2089 1
Onchocerca volvulus 0.003 0.0244 0.0405
Schistosoma mansoni tyrosine kinase 0.0009 0.0002 0.0002
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0016 0.0076 0.0077
Loa Loa (eye worm) hypothetical protein 0.0048 0.0453 0.0675
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0412 0.17
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.001 0.0009 0.0007
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.003 0.0236 0.0246
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0523 0.5977 0.623
Echinococcus multilocularis NCK adaptor protein 0.0013 0.0043 0.0041
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0016 0.0076 0.0077
Echinococcus granulosus C2 calcium dependent membrane targeting 0.001 0.0009 0.0007
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0041 0.0373 0.0371
Onchocerca volvulus 0.0164 0.1803 0.3014
Echinococcus granulosus intermediate filament protein 0.0033 0.0272 0.0281
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0049 0.046 0.1934
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0013 0.0043 0.0045
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Loa Loa (eye worm) hypothetical protein 0.0189 0.2089 0.3118
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0089 0.0934 0.1392
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0041 0.0373 0.0621
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.001 0.0009 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0412 0.0867
Brugia malayi Synaptic glycoprotein SC2 0.0027 0.0201 0.0334
Brugia malayi MH2 domain containing protein 0.0116 0.1238 0.2069
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0089 0.0934 0.156
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0049 0.046 0.0479
Brugia malayi hypothetical protein 0.001 0.0009 0.0012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.2109 0.3526
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0523 0.5977 0.8926
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0049 0.046 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0443 0.0441
Echinococcus multilocularis zinc finger protein 0.0021 0.0137 0.0135
Echinococcus granulosus pdz domain containing protein 0.001 0.0009 0.0007
Schistosoma mansoni hypothetical protein 0.0096 0.1015 0.1058
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0089 0.0934 0.0932
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Brugia malayi Latrophilin receptor protein 2 0.0096 0.1015 0.1696
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.2109 0.2198
Brugia malayi hypothetical protein 0.0041 0.0373 0.0621
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0009 0.0007
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0728 0.0759
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0009 0.0011
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0027 0.0201 0.0208
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0189 0.2089 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0441 0.0656
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0412 0.17
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0041 0.0373 0.0554
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0049 0.046 0.1416
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0523 0.5977 0.623
Loa Loa (eye worm) hypothetical protein 0.0044 0.0403 0.06
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Onchocerca volvulus 0.0164 0.1803 0.3014
Echinococcus multilocularis glycine receptor subunit beta 0.0089 0.0934 0.0932
Loa Loa (eye worm) hypothetical protein 0.0048 0.0453 0.0675
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0049 0.046 0.1934
Loa Loa (eye worm) hypothetical protein 0.0123 0.1323 0.1973
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Schistosoma mansoni lamin 0.0033 0.0272 0.0283
Schistosoma mansoni leucine-rich repeat protein 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0453 0.0675
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0441 0.046
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0009 0.0012
Echinococcus granulosus GPCR family 2 0.0096 0.1015 0.1056
Echinococcus granulosus FTZ F1 alpha 0.001 0.0009 0.0007
Schistosoma mansoni hypothetical protein 0.0345 0.3903 0.4069
Brugia malayi cell junction protein LIN-7 0.001 0.0009 0.0012
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.003 0.0236 0.0234
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0049 0.046 0.0766
Echinococcus granulosus multiple pdz domain protein 0.001 0.0009 0.0007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0009 0.0007
Schistosoma mansoni discs lost-related 0.001 0.0009 0.0009
Echinococcus granulosus tyrosine protein kinase Src42A 0.0016 0.0076 0.0077
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0443 0.0441
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Onchocerca volvulus 0.0164 0.1803 0.3014
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.1015 0.1056
Entamoeba histolytica hypothetical protein 0.0048 0.0453 0.2164
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0191 0.0603
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0041 0.0373 0.0621
Schistosoma mansoni MAGUK homolog 0.0011 0.002 0.002
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0049 0.046 0.1934
Echinococcus multilocularis eukaryotic initiation factor 4A 0.003 0.0236 0.0234
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.003 0.0236 0.0828
Leishmania major eukaryotic initiation factor 4a, putative 0.003 0.0236 0.0828
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0009 0.0012
Brugia malayi cDNA sequence BC016226 0.0049 0.046 0.0766
Loa Loa (eye worm) X11 protein 0.001 0.0009 0.001
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0443 0.0462
Brugia malayi Synapse defective protein 1 0.001 0.0009 0.0012
Brugia malayi gopc protein 0.001 0.0009 0.0012
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0049 0.046 0.0477
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0305 0.3441 0.5755
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Schistosoma mansoni tyrosine kinase 0.0009 0.0002 0.0002
Schistosoma mansoni growth factor receptor-bound protein 0.0013 0.0043 0.0045
Onchocerca volvulus 0.001 0.0009 0.0012
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.9594 0.9594
Brugia malayi 9ORF binding protein 1 0.001 0.0009 0.0012
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0089 0.0934 0.0932
Loa Loa (eye worm) hypothetical protein 0.0164 0.1803 0.269
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0011
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0164 0.1803 0.1879
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0049 0.046 0.1934
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0272 0.0403
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0171 0.0179
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0016 0.0076 0.0074
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0049 0.046 0.1934
Loa Loa (eye worm) hypothetical protein 0.0054 0.0519 0.0772
Onchocerca volvulus 0.0027 0.0201 0.0334
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0523 0.5977 0.5977
Echinococcus granulosus disks large 3 0.001 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0041 0.0373 0.0621
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0009 0.0007
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0075 0.0073
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0236 0.0143
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0027 0.0201 0.0956
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0009 0.0012
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0009 0.0007
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0523 0.5977 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0089 0.0087
Onchocerca volvulus 0.0089 0.0934 0.156
Onchocerca volvulus 0.0143 0.1553 0.2596
Brugia malayi hypothetical protein 0.0041 0.0373 0.0621
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0049 0.046 0.0458
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0008 0.0006
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0049 0.046 0.0458
Echinococcus granulosus Na:H exchange regulatory cofactor NHE RF2 0.001 0.0009 0.0007
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0189 0.2089 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.2109 0.3147
Schistosoma mansoni MAGUK homolog 0.001 0.0009 0.0009
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.003 0.0236 0.1123
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Brugia malayi gamma-syntrophin-like protein SYN2 0.001 0.0009 0.0012
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.003 0.0236 0.0828
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0236 0.0143
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.003 0.0236 0.0392
Echinococcus granulosus disks large 1 0.001 0.0009 0.0007
Echinococcus multilocularis disks large 1 0.001 0.0009 0.0007
Loa Loa (eye worm) PHD-finger family protein 0.002 0.013 0.0192
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0027 0.0201 0.0056
Echinococcus multilocularis glycine receptor subunit beta 0.0089 0.0934 0.0932
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Onchocerca volvulus 0.001 0.0009 0.0012
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.001 0.0009 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0305 0.3441 0.5137
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0041 0.0373 0.0621
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0009 0.0012
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0009 0.0007
Echinococcus granulosus Microtubule-associated serine/threonine-protein kinase 0.0011 0.002 0.0018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0089 0.0934 0.156
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0519 0.0539
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.2109 0.2196
Loa Loa (eye worm) hypothetical protein 0.0048 0.0453 0.0675
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0412 0.0428
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0143 0.1553 0.2317
Loa Loa (eye worm) hypothetical protein 0.0048 0.0453 0.0675
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.5228 0.5227
Echinococcus multilocularis glutamate receptor interacting protein 1 0.001 0.0009 0.0007
Echinococcus multilocularis MAGUK p55 subfamily 0.001 0.0009 0.0007
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0519 0.0517
Schistosoma mansoni fad oxidoreductase 0.0049 0.046 0.0479
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.056 0.1946
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0089 0.0934 0.0932
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0412 0.043
Schistosoma mansoni thyroid hormone receptor 0.001 0.0009 0.0009
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0096 0.0141
Schistosoma mansoni zinc finger protein 0.0021 0.0137 0.0143
Echinococcus granulosus protein lin 7 B 0.001 0.0009 0.0007
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0443 0.046
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 0.2089 1
Echinococcus multilocularis ligand of numb protein x 2 0.001 0.0009 0.0007
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0089 0.0934 0.0973
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0307 0.0305
Loa Loa (eye worm) AGC/MAST/MAST protein kinase 0.0011 0.002 0.0026
Toxoplasma gondii hypothetical protein 0.0049 0.046 0.1416
Echinococcus multilocularis tight junction protein ZO 3 0.001 0.0009 0.0007
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0009 0.0007
Echinococcus granulosus partitioning defective 3 0.001 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0049 0.046 0.0684
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Brugia malayi hypothetical protein 0.0026 0.0191 0.0316
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0049 0.046 0.1934
Brugia malayi PHD-finger family protein 0.0026 0.0199 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0305 0.3441 0.5137
Brugia malayi Calcitonin receptor-like protein seb-1 0.0305 0.3441 0.5755
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0089 0.0093
Loa Loa (eye worm) guanylate kinase 0.0016 0.0083 0.0121
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0089 0.0934 0.1392
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.003 0.0236 0.0828
Brugia malayi SRC-1 0.0016 0.0076 0.0124
Echinococcus granulosus eukaryotic initiation factor 4A 0.003 0.0236 0.0244
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0009 0.0007
Schistosoma mansoni d-amino acid oxidase 0.0584 0.6696 0.698
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0523 0.5977 0.5977
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0089 0.0934 0.0973
Echinococcus granulosus synaptic glycoprotein sc2 0.0027 0.0201 0.0208
Loa Loa (eye worm) hypothetical protein 0.0208 0.2318 0.346
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0089 0.0934 0.0973
Loa Loa (eye worm) hypothetical protein 0.007 0.0708 0.1055
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0089 0.0934 0.156
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0089 0.0934 0.156
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0016 0.0076 0.0074
Onchocerca volvulus 0.001 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0061
Brugia malayi PDZ domain containing protein 0.001 0.0009 0.0012
Echinococcus granulosus NCK adaptor protein 0.0013 0.0043 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.2109 0.2196
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0307 0.0318
Entamoeba histolytica hypothetical protein 0.0072 0.0728 0.348
Brugia malayi latrophilin 2 splice variant baaae 0.0208 0.2318 0.3876
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0089 0.0934 0.156
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0049 0.046 0.1934
Onchocerca volvulus 0.001 0.0009 0.0012
Plasmodium falciparum eukaryotic initiation factor 4A 0.003 0.0236 0.169
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0412 0.17
Echinococcus multilocularis multiple pdz domain protein 0.001 0.0009 0.0007
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0049 0.046 0.1934
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0443 0.0462
Onchocerca volvulus Putative fad oxidoreductase 0.0049 0.046 0.0766
Schistosoma mansoni PDZ domain protein 0.001 0.0009 0.0009
Onchocerca volvulus 0.0028 0.0224 0.0371
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0191 0.0603
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0584 0.6696 1
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.001 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0048 0.0453 0.0675
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0441 0.0439
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.9594 1
Echinococcus granulosus nAChR subunit 0.0048 0.0453 0.0471
Onchocerca volvulus 0.0089 0.0934 0.156
Brugia malayi Bromodomain containing protein 0.0076 0.0777 0.1297
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0076 0.0074
Schistosoma mansoni cpg binding protein 0.0028 0.0224 0.0233
Echinococcus granulosus tyrosine protein kinase Lyn 0.0017 0.0087 0.0089
Echinococcus granulosus pdz domain containing protein 0.001 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0049 0.046 0.0684
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0026 0.0025
Echinococcus granulosus rho guanine nucleotide exchange factor 12 0.001 0.0009 0.0007
Schistosoma mansoni afadin (af-6 protein) 0.001 0.0009 0.0009
Echinococcus granulosus tight junction protein ZO 3 0.001 0.0009 0.0007
Echinococcus multilocularis growth factor receptor bound protein 2 0.0013 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Loa Loa (eye worm) hypothetical protein 0.0032 0.0265 0.0392
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0009 0.0009
Echinococcus multilocularis beta 1 syntrophin 0.001 0.0009 0.0007
Echinococcus multilocularis multiple pdz domain protein 0.001 0.0009 0.0007
Echinococcus multilocularis protein lin 7 B 0.001 0.0009 0.0007
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.001 0.0009 0.0007
Loa Loa (eye worm) PAR-6 protein 0.001 0.0009 0.001
Onchocerca volvulus Arc homolog 0.001 0.0009 0.0012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0009 0.0007
Schistosoma mansoni acetylcholine receptor-related 0.0041 0.0373 0.0389
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0016 0.0076 0.0074
Schistosoma mansoni multiple pdz domain protein 0.001 0.0009 0.0009
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0076 0.0074
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0009 0.0007
Brugia malayi interleukin-16 0.001 0.0009 0.0012
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0027 0.0201 0.02
Plasmodium vivax RNA helicase-1, putative 0.003 0.0236 0.169
Echinococcus granulosus lamin dm0 0.0033 0.0272 0.0281
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0009 0.0007
Brugia malayi rho guanine nucleotide exchange factor 12 0.001 0.0009 0.0012
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0076 0.0074
Echinococcus granulosus myeloid:lymphoid or mixed lineage leukemia 0.001 0.0009 0.0007
Schistosoma mansoni lin-7-like proteins 0.001 0.0009 0.0009
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.001 0.0009 0.0012
Onchocerca volvulus 0.0235 0.2633 0.4403
Echinococcus multilocularis synaptic glycoprotein sc2 0.0027 0.0201 0.02
Schistosoma mansoni tyrosine kinase 0.0016 0.0076 0.0079
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0412 0.041
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0089 0.0934 0.0932
Echinococcus granulosus c src tyrosine kinase 0.0016 0.0076 0.0077
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0443 0.0659
Loa Loa (eye worm) hypothetical protein 0.0047 0.0443 0.0659
Schistosoma mansoni cpg binding protein 0.0032 0.0265 0.0276
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0016 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Loa Loa (eye worm) MBCTL1 0.0054 0.0519 0.0772
Brugia malayi DIX domain containing protein 0.001 0.0009 0.0012
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0089 0.0091
Echinococcus granulosus neurabin 1 0.001 0.0009 0.0007
Echinococcus multilocularis neurabin 1 0.001 0.0009 0.0007
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0016 0.0076 0.0077
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.001 0.0014 0.0012
Schistosoma mansoni NAD dehydrogenase 0.0049 0.046 0.0479
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.001 0.0009 0.0007
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Brugia malayi C2 domain containing protein 0.001 0.0009 0.0012
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0048 0.0453 0.0756
Schistosoma mansoni multiple pdz domain protein 0.001 0.0009 0.0009
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.001 0.0009 0.0007
Echinococcus granulosus neuropeptide s receptor 0.0458 0.5228 0.5449
Echinococcus multilocularis MAGUK p55 subfamily 0.001 0.0009 0.0007
Echinococcus multilocularis pdz domain containing protein 0.001 0.0009 0.0007
Echinococcus granulosus amyloid beta A4 protein 0.001 0.0009 0.0007
Echinococcus multilocularis pdz domain containing protein 0.001 0.0009 0.0007
Schistosoma mansoni dishevelled 0.001 0.0009 0.0009
Schistosoma mansoni syntenin 0.001 0.0009 0.0009
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0089 0.0934 0.1392
Brugia malayi hypothetical protein 0.0041 0.0373 0.0621
Loa Loa (eye worm) SRC-1 0.0016 0.0076 0.0111
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Onchocerca volvulus 0.0033 0.0272 0.0451
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Echinococcus multilocularis protein piccolo 0.001 0.0009 0.0007
Brugia malayi hypothetical protein 0.0017 0.0085 0.0139
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0009 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0096 0.0157
Loa Loa (eye worm) hypothetical protein 0.0523 0.5977 0.8926
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0244 0.0254
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0089 0.0934 0.156
Loa Loa (eye worm) hypothetical protein 0.0045 0.0412 0.0613
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.1015 0.1013
Brugia malayi hypothetical protein 0.0143 0.1553 0.2596
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0224 0.0232
Onchocerca volvulus 0.001 0.0009 0.0012
Echinococcus granulosus tyrosine protein kinase ABL1 0.0209 0.2322 0.2419
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.001 0.0009 0.001
Loa Loa (eye worm) guanylate kinase 0.001 0.0009 0.001
Echinococcus granulosus MAGUK p55 subfamily 0.001 0.0009 0.0007
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0089 0.0934 0.156
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0009 0.0007
Brugia malayi Ferm domain 0.001 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0049 0.046 0.0479
Echinococcus multilocularis lamin 0.0033 0.0272 0.027
Loa Loa (eye worm) cell junction protein LIN-7 0.001 0.0009 0.001
Echinococcus multilocularis multiple pdz domain protein 0.001 0.0009 0.0007
Echinococcus multilocularis partitioning defective protein 6 0.001 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0099
Echinococcus granulosus PRKCA binding protein 0.001 0.0009 0.0007
Onchocerca volvulus 0.0041 0.0373 0.0621
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0272 0.0451
Brugia malayi Cation transporter family protein 0.0164 0.1803 0.3014
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0011
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0011 0.002 0.0018
Echinococcus multilocularis partitioning defective 3 0.001 0.0009 0.0007
Schistosoma mansoni hypothetical protein 0.0345 0.3903 0.4069
Echinococcus multilocularis PRKCA binding protein 0.001 0.0009 0.0007
Onchocerca volvulus 0.0041 0.0373 0.0621
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0013 0.0043 0.0061
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0009 0.0012
Schistosoma mansoni amyloid beta A4 protein related 0.001 0.0009 0.0009
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0009 0.0007
Brugia malayi Pre-SET motif family protein 0.003 0.0244 0.0405
Brugia malayi Bromodomain containing protein 0.0038 0.0334 0.0556
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0554
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0009 0.0007
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0076 0.0077
Loa Loa (eye worm) hypothetical protein 0.0089 0.0934 0.1392
Echinococcus granulosus Rho GTPase activating protein 21 0.001 0.0009 0.0007
Schistosoma mansoni leucine-rich repeat protein 0.001 0.0009 0.0009
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0049 0.046 0.1934
Onchocerca volvulus 0.001 0.0009 0.0012
Schistosoma mansoni hypothetical protein 0.0072 0.0728 0.0759
Schistosoma mansoni zinc finger protein 0.0015 0.0069 0.0072
Brugia malayi Patj homolog 0.001 0.0009 0.0012
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.001 0.0009 0.0007
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0049 0.046 0.1934
Brugia malayi PDZ domain 0.001 0.0009 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.2109 0.2107
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0441 0.0458
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.001
Onchocerca volvulus 0.0017 0.0094 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0201 0.0298
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0079 0.0813 0.1211
Echinococcus multilocularis PDZ domain containing protein GIPC3 0.001 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0011
Schistosoma mansoni pdz domain containing protein 0.001 0.0009 0.0009
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0771 0.8868 0.9243
Schistosoma mansoni hypothetical protein 0.0096 0.1015 0.1058
Brugia malayi hypothetical protein 0.001 0.0009 0.0012
Onchocerca volvulus Big bang homolog 0.001 0.0009 0.0012
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0041 0.0373 0.0554
Schistosoma mansoni thyroid hormone receptor 0.001 0.0009 0.0009
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0013 0.0043 0.0061
Echinococcus granulosus glycine receptor subunit alpha 1 0.0089 0.0934 0.0972
Loa Loa (eye worm) histone methyltransferase 0.001 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0096 0.1015 0.1513
Loa Loa (eye worm) hypothetical protein 0.0048 0.0453 0.0675
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0009 0.0007
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0048 0.0453 0.0756
Plasmodium vivax polyprenol reductase, putative 0.0027 0.0201 0.0392
Loa Loa (eye worm) PDZ-domain-containing protein scribble 0.001 0.0009 0.001
Brugia malayi protein kinase C-binding protein PICK1 0.001 0.0009 0.0012
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0089 0.0934 0.0932
Loa Loa (eye worm) hypothetical protein 0.0026 0.0191 0.0282
Echinococcus multilocularis Rho GTPase activating protein 21 0.001 0.0009 0.0007
Echinococcus multilocularis pdz domain containing protein 0.001 0.0009 0.0007
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0443 0.0738
Loa Loa (eye worm) hypothetical protein 0.0027 0.0201 0.0298
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0009 0.0007
Brugia malayi hypothetical protein 0.001 0.0009 0.0012
Schistosoma mansoni nAChR subunit 0.0089 0.0934 0.0973
Echinococcus granulosus microtubule associated protein 2 0.0833 0.9594 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0209 0.2322 0.3465
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.001 0.0009 0.0007

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 97 % Inhibition of HDAC in human Hela cells nuclear extracts assessed as residual activity at 500 uM by fluorimetric assay ChEMBL. 19520580
IC50 (binding) = 745 nM Inhibition of human DAO ChEMBL. 18455394
IC50 (binding) > 5000 nM Inhibition of human DDO ChEMBL. 18455394
IC50 (binding) = 106 uM Activity against rat cortical and hippocampal membrane strychnine-insensitive N-methyl-D-aspartate glutamate receptor 1 using [3H]-gly ChEMBL. 2146391
IC50 (binding) = 106 uM Ability to compete with [3H]-glycine for strychnine-insensitive binding sites on rat cortical and hippocampal membrane ChEMBL. 1534125
IC50 (binding) = 106 uM Activity against rat cortical and hippocampal membrane strychnine-insensitive N-methyl-D-aspartate glutamate receptor 1 using [3H]-gly ChEMBL. 2146391
IC50 (binding) = 106 uM Ability to compete with [3H]-glycine for strychnine-insensitive binding sites on rat cortical and hippocampal membrane ChEMBL. 1534125
IC50 (binding) = 4200 uM Activity against rat cortical and hippocampal membrane N-methyl-D-aspartate glutamate receptor 1/2A/2B/2C/2D using [3H]-CPP ChEMBL. 2146391
IC50 (binding) = 4200 uM Ability to compete with [3H]-CCP for rat cortical and hippocampal membrane glutamate binding site. ChEMBL. 1534125
IC50 (binding) = 4200 uM Activity against rat cortical and hippocampal membrane N-methyl-D-aspartate glutamate receptor 1/2A/2B/2C/2D using [3H]-CPP ChEMBL. 2146391
Inhibition (ADMET) = 117.7618005 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 121.3654746 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Kd (binding) ~ 12 uM Dissociation constant for HCV NS3 protease substrate binding site ChEMBL. 15115392
Kd (binding) ~ 12 uM Dissociation constant for HCV NS3 protease substrate binding site ChEMBL. 15115392
Ki (binding) nM Apparent inhibition constant of the compound against recombinant human Steroid 5-alpha-reductase type I expressed in CHO cells ChEMBL. 7837223
Ki (binding) = 230 nM Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells ChEMBL. 7837223
Ki (binding) = 3.4 uM Competitive inhibition of pig kidney DAAO in presence of D-alanine ChEMBL. 23631755
Ki (binding) > 100 uM Inhibition of strychnine-insensitive [3H]-glycine binding to the N-methyl-D-aspartate glutamate receptor of synaptic plasma membranes(SPM) prepared from rat forebrain ChEMBL. 1849994
Ki (binding) > 100 uM Inhibition of strychnine-insensitive [3H]-glycine binding to the N-methyl-D-aspartate glutamate receptor of synaptic plasma membranes(SPM) prepared from rat forebrain ChEMBL. 1849994
Ki (binding) > 1000 uM Displacement of FITC-AHx-KALETLRRVGDGVQRNHETAF-NH2 from human MCl1 (172 to 327) expressed in Escherichia coli BL21 (DE3) after 1 hr by fluorescence polarization anisotropy assay ChEMBL. 23244564
Ki (binding) > 1000 uM Displacement of FITC-Bak-BH3 peptide from Mcl-1 (unknown origin) incubated for 1.5 hrs by FPA competition assay ChEMBL. 25844895
Ki app (binding) 0 nM Apparent inhibition constant of the compound against recombinant human Steroid 5-alpha-reductase type I expressed in CHO cells ChEMBL. 7837223
Ki app (binding) = 230 nM Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells ChEMBL. 7837223
Potency (functional) 0.7308 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 1.122 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Ratio (binding) = 40 Selectivity ratio for CPP and gly NMDA binding ChEMBL. 2146391
Ratio (binding) = 40 Ratio of the inhibitory activity against [3H]-CCP for rat cortical and hippocampal membrane glutamate binding site to [3H]-glycine for rat cortical and hippocampal membrane binding site. ChEMBL. 1534125

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

10 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.