Detailed information for compound 334066

Basic information

Technical information
  • TDR Targets ID: 334066
  • Name: [(2S,3S)-4-(ethylamino)-3-[4-(4-fluorophenyl) phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4- dioxobutan-2-yl]azanium; 2,2,2-trifluoroaceta te
  • MW: 515.473 | Formula: C24H26F5N3O4
  • H donors: 3 H acceptors: 4 LogP: 1.05 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.CCNC(=O)[C@H]([C@@H](C(=O)N1CC[C@@H](C1)F)N)c1ccc(cc1)c1ccc(cc1)F
  • InChi: 1S/C22H25F2N3O2.C2HF3O2/c1-2-26-21(28)19(20(25)22(29)27-12-11-18(24)13-27)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15;3-2(4,5)1(6)7/h3-10,18-20H,2,11-13,25H2,1H3,(H,26,28);(H,6,7)/t18-,19-,20-;/m0./s1
  • InChiKey: CHTKDMNAVPLLMT-HBSNOMOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(1S,2S)-3-(ethylamino)-2-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidine-1-carbonyl]-3-oxo-propyl]ammonium; 2,2,2-trifluoroacetate
  • [(1S,2S)-3-(ethylamino)-2-[4-(4-fluorophenyl)phenyl]-1-[[(3S)-3-fluoro-1-pyrrolidinyl]-oxomethyl]-3-oxopropyl]ammonium; 2,2,2-trifluoroacetate
  • [(2S,3S)-4-(ethylamino)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-butan-2-yl]azanium; 2,2,2-trifluoroethanoate
  • [(1S,2S)-3-(ethylamino)-2-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidine-1-carbonyl]-3-keto-propyl]ammonium; 2,2,2-trifluoroacetate
  • [(2S,3S)-4-ethylamino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]azanium; 2,2,2-trifluoroacetate
  • [(1S,2S)-3-ethylamino-2-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidine-1-carbonyl]-3-oxo-propyl]ammonium; 2,2,2-trifluoroacetate
  • [(1S,2S)-3-ethylamino-2-[4-(4-fluorophenyl)phenyl]-1-[[(3S)-3-fluoro-1-pyrrolidinyl]-oxomethyl]-3-oxopropyl]ammonium; 2,2,2-trifluoroacetate
  • [(1S,2S)-3-ethylamino-2-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidine-1-carbonyl]-3-keto-propyl]ammonium; 2,2,2-trifluoroacetate
  • [(2S,3S)-4-ethylamino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-butan-2-yl]azanium; 2,2,2-trifluoroethanoate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0026 0.0028 0.0008
Echinococcus multilocularis short transient receptor potential channel 6 0.0061 0.0164 0.0164
Echinococcus granulosus acetylcholinesterase 0.0071 0.02 0.0543
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0023 0.0213
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Brugia malayi nuclear hormone receptor 0.0031 0.0048 0.0092
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Onchocerca volvulus 0.0072 0.0206 0.035
Plasmodium falciparum phd finger protein, putative 0.0028 0.0036 0.0353
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.003 0.0046 0.0088
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0052 0.0128 0.0243
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0025 0.0023 0.0131
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0196 0.0679 0.1284
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0166 0.0566 0.1539
Loa Loa (eye worm) hypothetical protein 0.0108 0.0342 0.0651
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0211 0.0736 0.1364
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0048 0.0092
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0048 0.0092
Schistosoma mansoni phd/f-box containing protein 0.0024 0.0021 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.0285 0.0774
Mycobacterium ulcerans hypothetical protein 0.0072 0.0206 0.0381
Echinococcus granulosus dna polymerase eta 0.002 0.0006 0.0018
Onchocerca volvulus 0.0979 0.3681 0.7001
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.0285 0.0774
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0052 0.0128 0.0243
Schistosoma mansoni lamin 0.0026 0.0028 0.0053
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.0698 0.133
Plasmodium falciparum heat shock protein 90, putative 0.0178 0.0612 1
Echinococcus multilocularis neuropeptide Y receptor 0.0093 0.0285 0.0285
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0025 0.014
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0023 0.0213
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.003 0.0046 0.0126
Schistosoma mansoni coup transcription factor 0.0031 0.0048 0.0092
Loa Loa (eye worm) hypothetical protein 0.0166 0.0566 0.1079
Leishmania major zinc binding dehydrogenase-like protein 0.0196 0.0679 0.5198
Echinococcus granulosus Niemann Pick C1 protein 0.0298 0.1072 0.2912
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0092
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0046 0.0088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.039 0.1422 0.271
Echinococcus multilocularis polycomb protein SCMH1 0.0045 0.0104 0.0104
Brugia malayi putative neuropeptide receptor NPR1 0.0093 0.0285 0.0543
Trypanosoma brucei C-8 sterol isomerase, putative 0.0358 0.1301 1
Brugia malayi jmjC domain containing protein 0.0024 0.0021 0.004
Onchocerca volvulus 0.0228 0.0803 0.1492
Echinococcus multilocularis lamin dm0 0.0026 0.0028 0.0028
Brugia malayi neuropeptide F receptor 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.009 0.0272 0.0519
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0092
Brugia malayi Alcohol dehydrogenase class III 0.1388 0.5248 1
Echinococcus granulosus G protein coupled receptor 139 0.0093 0.0285 0.0774
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Plasmodium falciparum endoplasmin, putative 0.0051 0.0124 0.1822
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Echinococcus granulosus JmjC domain containing protein 4 0.0024 0.0021 0.0057
Echinococcus multilocularis conserved hypothetical protein 0.072 0.2687 0.2687
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0025 0.0023 0.0213
Loa Loa (eye worm) hypothetical protein 0.0457 0.1682 0.3206
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0048 0.0091
Loa Loa (eye worm) hypothetical protein 0.0166 0.0566 0.1079
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0048 0.0092
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0166 0.0566 0.1079
Mycobacterium tuberculosis Conserved hypothetical protein 0.0152 0.051 0.0961
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0022 0.0015 0.0016
Toxoplasma gondii hypothetical protein 0.0166 0.0566 0.1054
Giardia lamblia PHD finger protein 15 0.0028 0.0036 0.1408
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Onchocerca volvulus 0.0093 0.0285 0.05
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0093 0.0285 0.0543
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0048 0.0092
Echinococcus multilocularis sodium and chloride dependent glycine 0.0166 0.0566 0.0566
Plasmodium falciparum peptidase, putative 0.0033 0.0057 0.0699
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0036 0.0353
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0046 0.0088
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0196 0.0679 0.0679
Echinococcus granulosus peregrin 0.0037 0.0071 0.0192
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0206 0.0561
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Brugia malayi prolyl oligopeptidase family protein 0.0208 0.0726 0.1384
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0025 0.0047
Onchocerca volvulus Alhambra homolog 0.0028 0.0036 0.0024
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0208 0.0726 0.556
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0196 0.0679 0.1284
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0042 0.0089 0.0126
Echinococcus multilocularis G-protein coupled receptor, putative 0.0093 0.0285 0.0285
Echinococcus granulosus 7TM GPCR rhodopsin 0.0093 0.0285 0.0774
Toxoplasma gondii heat shock protein 90, putative 0.0075 0.0215 0.0383
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0057 0.0694
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0196 0.0679 0.1284
Brugia malayi hypothetical protein 0.0093 0.0285 0.0543
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0033 0.0057 0.0629
Onchocerca volvulus 0.0046 0.0106 0.0157
Echinococcus granulosus g protein coupled receptor 0.0093 0.0285 0.0774
Plasmodium vivax SET domain protein, putative 0.0031 0.0048 0.0548
Echinococcus granulosus neuropeptides capa receptor 0.0093 0.0285 0.0774
Echinococcus granulosus histone acetyltransferase MYST2 0.0052 0.0128 0.0347
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.003 0.0046 0.0126
Trypanosoma brucei heat shock protein, putative 0.0075 0.0215 0.1614
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0285 0.0543
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0033 0.0057 0.0096
Schistosoma mansoni amine GPCR 0.0093 0.0285 0.0543
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.003 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0057 0.0387
Trypanosoma brucei heat shock protein, putative 0.0075 0.0215 0.1614
Brugia malayi hypothetical protein 0.0024 0.0021 0.0041
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0166 0.0566 0.1079
Treponema pallidum sodium- and chloride- dependent transporter 0.0979 0.3681 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0057 0.0699
Echinococcus multilocularis nAChR subunit 0.003 0.0046 0.0046
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0066 0.0181 0.0317
Onchocerca volvulus 0.0093 0.0285 0.05
Mycobacterium ulcerans alcohol dehydrogenase AdhA 0.0071 0.0202 0.0374
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0358 0.1301 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0093 0.0285 0.0543
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0055 0.0093
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0092
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0196 0.0679 0.1284
Schistosoma mansoni myosin xvIII 0.0093 0.0285 0.0543
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0046 0.0126
Loa Loa (eye worm) hypothetical protein 0.0196 0.0679 0.1294
Onchocerca volvulus 0.0093 0.0285 0.05
Trichomonas vaginalis set domain proteins, putative 0.0228 0.0803 1
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0196 0.0679 0.5198
Loa Loa (eye worm) hypothetical protein 0.0166 0.0566 0.1079
Loa Loa (eye worm) hypothetical protein 0.0086 0.0258 0.0491
Plasmodium vivax basic transcription factor 3b, putative 0.0033 0.0057 0.0708
Loa Loa (eye worm) hypothetical protein 0.0117 0.0377 0.0718
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0979 0.3681 0.7014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0285 0.0285
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0196 0.0679 0.1284
Brugia malayi steroid hormone receptor 0.0031 0.0048 0.0092
Echinococcus granulosus short transient receptor potential channel 6 0.0061 0.0164 0.0445
Schistosoma mansoni opsin-like receptor 0.0093 0.0285 0.0543
Loa Loa (eye worm) mbt repeat family protein 0.0045 0.0104 0.0197
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0093 0.0285 0.0774
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.0285 0.0774
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.003 0.0046 0.0126
Schistosoma mansoni nAChR subunit 0.003 0.0046 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0048 0.0091
Entamoeba histolytica hypothetical protein 0.0022 0.0015 0.0116
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0196 0.0679 0.1284
Echinococcus multilocularis jumonji domain containing 1A 0.0024 0.0021 0.0021
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0163 0.031
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0046 0.0088
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0196 0.0679 0.1284
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.1388 0.5248 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0379 0.0696
Echinococcus granulosus tar DNA binding protein 0.006 0.0161 0.0437
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0055 0.0376
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0033 0.0057 0.0387
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0093 0.0285 0.0543
Onchocerca volvulus 0.0093 0.0285 0.05
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.003 0.0046 0.0088
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0046 0.0088
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0033 0.0057 0.008
Onchocerca volvulus 0.0093 0.0285 0.05
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.028 0.1001 0.1907
Schistosoma mansoni quinone oxidoreductase 0.0071 0.0202 0.0386
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0006 0.0018
Loa Loa (eye worm) LGC-31 protein 0.003 0.0046 0.0088
Brugia malayi Serine carboxypeptidase S28 family protein 0.0025 0.0023 0.0045
Brugia malayi follicle stimulating hormone receptor 0.0315 0.1136 0.2165
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0023 0.0235
Loa Loa (eye worm) beta-lactamase 0.0072 0.0206 0.0393
Echinococcus multilocularis heat shock protein 0.0075 0.0215 0.0215
Brugia malayi hypothetical protein 0.0627 0.2332 0.4444
Loa Loa (eye worm) nuclear hormone receptor 0.01 0.0314 0.0598
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0022 0.0015 0.0016
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0206 0.0206
Loa Loa (eye worm) acetylcholinesterase 1 0.0071 0.02 0.0381
Trypanosoma brucei DNA polymerase beta thumb, putative 0.004 0.0084 0.0603
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0096 0.0262
Toxoplasma gondii NAC domain-containing protein 0.0033 0.0057 0.0081
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0208 0.0726 0.556
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0023 0.0213
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0028 0.0053
Toxoplasma gondii heat shock protein 75, putative 0.0042 0.0089 0.0142
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0092
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0196 0.0679 0.127
Echinococcus granulosus tachykinin peptides receptor 99D 0.0093 0.0285 0.0774
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Schistosoma mansoni neuropeptide receptor 0.0093 0.0285 0.0543
Schistosoma mansoni hypothetical protein 0.0093 0.0285 0.0543
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0048 0.0092
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0048 0.0092
Echinococcus multilocularis lysine specific demethylase 5A 0.009 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0358 0.1301 0.2479
Schistosoma mansoni lamin 0.0026 0.0028 0.0053
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0033 0.0057 0.0629
Echinococcus multilocularis dna polymerase eta 0.002 0.0006 0.0006
Echinococcus multilocularis g protein coupled receptor 0.0093 0.0285 0.0285
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0196 0.0679 0.5198
Schistosoma mansoni biogenic amine (5HT) receptor 0.0485 0.1789 0.3409
Brugia malayi CXXC zinc finger family protein 0.0061 0.0163 0.031
Toxoplasma gondii hypothetical protein 0.0046 0.0107 0.0177
Onchocerca volvulus 0.003 0.0046 0.0044
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0093 0.0285 0.0543
Schistosoma mansoni cpg binding protein 0.0061 0.0163 0.031
Echinococcus multilocularis musashi 0.0026 0.0028 0.0028
Plasmodium vivax JmjC domain containing protein 0.0024 0.0021 0.0105
Mycobacterium ulcerans quinone reductase Qor 0.0196 0.0679 0.1284
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0055 0.0376
Echinococcus granulosus biogenic amine 5HT receptor 0.0485 0.1789 0.486
Echinococcus granulosus Niemann Pick C1 protein 0.0209 0.0729 0.198
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0091
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.0432 0.0823
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.003 0.0046 0.0126
Echinococcus multilocularis fmrfamide receptor 0.0093 0.0285 0.0285
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0096 0.0096
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0196 0.0679 0.8447
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0048 0.0048
Toxoplasma gondii prolyl endopeptidase 0.0033 0.0057 0.008
Loa Loa (eye worm) melatonin receptor type 1A 0.0093 0.0285 0.0543
Echinococcus multilocularis sterol regulatory element binding protein 0.009 0.0272 0.0272
Schistosoma mansoni DNA polymerase eta 0.002 0.0006 0.0012
Brugia malayi G protein-coupled receptor 0.0093 0.0285 0.0543
Trypanosoma cruzi Heat shock protein 83, putative 0.0075 0.0215 0.1614
Brugia malayi Carboxylesterase family protein 0.0071 0.02 0.0381
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0196 0.0679 0.5198
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0046 0.0046
Echinococcus multilocularis transcription factor btf3 0.0033 0.0057 0.0057
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0048 0.0092
Loa Loa (eye worm) ICD-1 protein 0.0033 0.0057 0.0109
Echinococcus multilocularis g-protein coupled receptor 0.0093 0.0285 0.0285
Mycobacterium leprae Probable lipase LipE 0.0072 0.0206 0.0366
Onchocerca volvulus 0.01 0.0312 0.0552
Echinococcus granulosus short transient receptor potential channel 6 0.0061 0.0164 0.0445
Brugia malayi ORL1-like opioid receptor 0.0093 0.0285 0.0543
Onchocerca volvulus 0.0166 0.0566 0.1039
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.007 0.0487
Schistosoma mansoni tar DNA-binding protein 0.006 0.0161 0.0306
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0196 0.0679 0.1284
Echinococcus multilocularis heat shock protein 90 0.0062 0.0167 0.0167
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0024 0.0021 0.0012
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0033 0.0057 0.0387
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0025 0.025
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.028 0.1001 0.1871
Mycobacterium ulcerans polyketide synthase 0.0196 0.0679 0.1284
Schistosoma mansoni sodium/chloride dependent transporter 0.0166 0.0566 0.1079
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0057 0.0387
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0048 0.0092
Loa Loa (eye worm) hypothetical protein 0.0117 0.0377 0.0718
Trypanosoma brucei Heat shock protein 83, putative 0.0075 0.0215 0.1614
Brugia malayi hypothetical protein 0.0093 0.0285 0.0543
Brugia malayi PHD-finger family protein 0.0028 0.0036 0.0068
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0093 0.0285 0.0543
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.003 0.0046 0.0088
Echinococcus multilocularis dna polymerase kappa 0.002 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0086 0.026 0.0496
Onchocerca volvulus 0.0093 0.0285 0.05
Echinococcus multilocularis neuropeptides capa receptor 0.0093 0.0285 0.0285
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0055 0.0376
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0028 0.0053
Schistosoma mansoni cpg binding protein 0.0064 0.0176 0.0335
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0048 0.0048
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0046 0.0088
Mycobacterium ulcerans oxidoreductase 0.0071 0.0202 0.0374
Onchocerca volvulus 0.003 0.0046 0.0044
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0206 0.1544
Echinococcus granulosus neuropeptide FF receptor 2 0.0093 0.0285 0.0774
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0166 0.0566 0.1079
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0456 0.1678 0.1678
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0096 0.0184
Schistosoma mansoni intermediate filament proteins 0.0026 0.0028 0.0053
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0206 0.251
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0057 0.0694
Brugia malayi ecdysteroid receptor 0.0031 0.0048 0.0092
Onchocerca volvulus 0.0124 0.0406 0.0733
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0147 0.0493 0.0493
Echinococcus granulosus heat shock protein 0.0075 0.0215 0.0585
Leishmania major oxidoreductase, putative 0.0196 0.0679 0.5198
Schistosoma mansoni tar DNA-binding protein 0.006 0.0161 0.0306
Mycobacterium leprae Probable oxidireductase 0.0196 0.0679 0.127
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0024 0.0021 0.0113
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0046 0.0088
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Brugia malayi hypothetical protein 0.0117 0.0377 0.0718
Brugia malayi jmjC domain containing protein 0.0024 0.0021 0.004
Onchocerca volvulus Prolyl endopeptidase homolog 0.0033 0.0057 0.0063
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0033 0.0057 0.0108
Plasmodium falciparum heat shock protein 90, putative 0.0038 0.0075 0.1013
Trypanosoma cruzi oxidoreductase, putative 0.0124 0.0406 0.309
Loa Loa (eye worm) hypothetical protein 0.004 0.0082 0.0156
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Loa Loa (eye worm) hypothetical protein 0.0979 0.3681 0.7014
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Onchocerca volvulus 0.0031 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Loa Loa (eye worm) fli-1 protein 0.0209 0.0732 0.1395
Onchocerca volvulus 0.0072 0.0206 0.035
Onchocerca volvulus 0.003 0.0046 0.0044
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.1388 0.5248 1
Echinococcus multilocularis prolyl endopeptidase 0.0033 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Echinococcus granulosus SAM and MBT domain containing protein 0.0045 0.0104 0.0281
Brugia malayi hypothetical protein 0.0076 0.0222 0.0422
Echinococcus multilocularis orexin receptor type 2 0.0093 0.0285 0.0285
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.028 0.1001 0.2719
Loa Loa (eye worm) solute carrier family 6 member 4 0.0979 0.3681 0.7014
Mycobacterium ulcerans oxidoreductase 0.0124 0.0406 0.0763
Echinococcus granulosus synaptic vesicle membrane protein VAT 1 0.0071 0.0202 0.055
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0093 0.0285 0.0285
Echinococcus multilocularis acetylcholinesterase 0.0071 0.02 0.02
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0456 0.1678 0.456
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0006 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.1698 0.3228
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0206 0.0381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0058 0.0152 0.029
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Echinococcus multilocularis synaptic vesicle membrane protein VAT 1 0.0071 0.0202 0.0202
Echinococcus granulosus dna polymerase kappa 0.002 0.0006 0.0018
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0034 0.0058 0.0158
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0025 0.0227
Schistosoma mansoni neuropeptide F-like receptor 0.0093 0.0285 0.0543
Brugia malayi Muscleblind-like protein 0.0484 0.1785 0.3401
Loa Loa (eye worm) MH2 domain-containing protein 0.0253 0.0899 0.1712
Echinococcus multilocularis somatostatin receptor 0.0093 0.0285 0.0285
Trypanosoma brucei heat shock protein 90, putative 0.0075 0.0215 0.1614
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0048 0.0092
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0124 0.0406 0.309
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0166 0.0566 0.1079
Toxoplasma gondii Hsp90 domain-containing protein 0.0178 0.0612 0.1141
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0036 0.0068
Plasmodium vivax heat shock protein, putative 0.0178 0.0612 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0048 0.0092
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0166 0.0566 0.1054
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0055 0.015
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0147 0.0493 0.1338
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.1388 0.5248 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Schistosoma mansoni heat shock protein 0.0042 0.0089 0.017
Trypanosoma brucei Trans-2-enoyl-ACP reductase 1, putative 0.0071 0.0202 0.1513
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0025 0.0023 0.0045
Onchocerca volvulus 0.0093 0.0285 0.05
Echinococcus multilocularis acetylcholinesterase 0.0071 0.02 0.02
Brugia malayi beta-NAC-like protein 0.0033 0.0057 0.0109
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0034 0.0058 0.0058
Brugia malayi hypothetical protein 0.0093 0.0285 0.0543
Schistosoma mansoni transient receptor potential channel 0.0061 0.0164 0.0312
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 0.1192 0.4498 0.8569
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0093 0.0285 0.0774
Mycobacterium tuberculosis Possible dehydrogenase 0.0196 0.0679 0.1284
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0206 0.0381
Brugia malayi G protein-coupled receptor F59B2.13 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Schistosoma mansoni alpha-1 adrenergic receptor 0.0093 0.0285 0.0543
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0024 0.0021 0.0012
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0222 0.0222
Echinococcus multilocularis Niemann Pick C1 protein 0.0298 0.1072 0.1072
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0285 0.0285
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0079 0.0233 0.0444
Onchocerca volvulus 0.0045 0.0104 0.0153
Giardia lamblia Thymus-specific serine protease precursor 0.0025 0.0023 0.0814
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0023 0.0235
Brugia malayi MH2 domain containing protein 0.0253 0.0899 0.1712
Schistosoma mansoni hypothetical protein 0.0086 0.026 0.0496
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0117 0.0376 0.0376
Schistosoma mansoni alcohol dehydrogenase 0.1388 0.5248 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0023 0.0213
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0285 0.0543
Echinococcus granulosus transcription factor btf3 0.0033 0.0057 0.0155
Echinococcus granulosus acetylcholinesterase 0.0071 0.02 0.0543
Echinococcus multilocularis g protein coupled receptor 0.0093 0.0285 0.0285
Brugia malayi isocitrate dehydrogenase 0.0033 0.0055 0.0105
Brugia malayi jmjC domain containing protein 0.0093 0.0286 0.0545
Echinococcus granulosus neuropeptide s receptor 0.0531 0.1964 0.5335
Schistosoma mansoni transient receptor potential channel 0.0061 0.0164 0.0312
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0057 0.0108
Brugia malayi Dopamine receptor 0.0093 0.0285 0.0543
Schistosoma mansoni neuropeptide F-like receptor 0.0093 0.0285 0.0543
Echinococcus granulosus neuropeptide Y receptor 0.0093 0.0285 0.0774
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.003 0.0046 0.0088
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Echinococcus multilocularis L aminoadipate semialdehyde 0.0079 0.0233 0.0233
Brugia malayi RE15519p 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0048 0.0092
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0208 0.0726 0.1384
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0048 0.0092
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.01 0.0312 0.0594
Trichomonas vaginalis heat shock protein, putative 0.0066 0.0181 0.219
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Onchocerca volvulus Putative alcohol dehydrogenase 0.1388 0.5248 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0048 0.0092
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0057 0.0694
Schistosoma mansoni jumonji/arid domain-containing protein 0.0093 0.0286 0.0545
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0166 0.0566 0.1079
Loa Loa (eye worm) MBCTL1 0.0052 0.0128 0.0243
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0956 0.3594 0.3594
Echinococcus granulosus phd:f box containing protein 0.0024 0.0021 0.0057
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0206 0.0393
Loa Loa (eye worm) G-protein coupled receptor 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0066 0.0181 0.0333
Toxoplasma gondii hypothetical protein 0.0166 0.0566 0.1054
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0036 0.004
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0093 0.0285 0.0774
Echinococcus granulosus TRP transient receptor potential channel 0.0034 0.0061 0.0166
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0979 0.3681 0.7014
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0166 0.0566 0.1054
Loa Loa (eye worm) hypothetical protein 0.0072 0.0206 0.0393
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0069 0.0194 0.0369
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0197
Schistosoma mansoni phosphatidylserine receptor 0.0024 0.0021 0.004
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Plasmodium vivax hypothetical protein, conserved 0.0166 0.0566 0.9238
Echinococcus granulosus dnaJ subfamily B 0.039 0.1422 0.3864
Loa Loa (eye worm) RNA binding protein 0.006 0.0161 0.0306
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0166 0.0566 0.0566
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0048 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0206 0.1544
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0136 0.0451 0.3435
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0166 0.0566 0.1079
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0206 0.251
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0048 0.0132
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0055 0.0055
Brugia malayi Dopamine receptor protein 2 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0166 0.0566 0.1079
Schistosoma mansoni adenoreceptor 0.0093 0.0285 0.0543
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0456 0.1678 0.3198
Onchocerca volvulus Putative nachr subunit 0.003 0.0046 0.0044
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Brugia malayi hypothetical protein 0.0093 0.0285 0.0543
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0048 0.0092
Brugia malayi Endoplasmin precursor 0.0075 0.0215 0.041
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.1388 0.5248 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0288 0.1032 0.792
Loa Loa (eye worm) hypothetical protein 0.0072 0.0206 0.0393
Onchocerca volvulus 0.0072 0.0206 0.035
Loa Loa (eye worm) hypothetical protein 0.0457 0.1682 0.3206
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0048 0.0092
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0006 0.0012
Loa Loa (eye worm) oxidoreductase 0.0071 0.0202 0.0386
Trypanosoma brucei heat shock protein, putative 0.0075 0.0215 0.1614
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0046 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0272 0.3339
Trypanosoma brucei heat shock protein, putative 0.0075 0.0215 0.1614
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Leishmania major C-8 sterol isomerase-like protein 0.0358 0.1301 1
Echinococcus granulosus neuropeptide receptor A26 0.0531 0.1964 0.5335
Schistosoma mansoni endoplasmin 0.0075 0.0215 0.041
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.004 0.0084 0.0603
Loa Loa (eye worm) hypothetical protein 0.0071 0.02 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0048 0.0092
Trypanosoma cruzi heat shock protein 85, putative 0.0075 0.0215 0.1614
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0045 0.0104 0.0197
Brugia malayi Hsp90 protein 0.0042 0.0089 0.017
Onchocerca volvulus 0.0166 0.0566 0.1039
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0048 0.0048
Brugia malayi neuropeptide F receptor 0.0093 0.0285 0.0543
Schistosoma mansoni nAChR subunit 0.003 0.0046 0.0088
Trypanosoma brucei heat shock protein, putative 0.0075 0.0215 0.1614
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0285 0.0285
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0046 0.0126
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0021 0.004
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0022 0.0015 0.0016
Toxoplasma gondii type I fatty acid synthase 0.0071 0.0202 0.0358
Echinococcus granulosus Dipeptidyl peptidase 9 0.0208 0.0726 0.1973
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0006 0.0012
Plasmodium falciparum heat shock protein 90 0.0075 0.0215 0.3358
Leishmania major zinc-binding dehydrogenase-like protein 0.0124 0.0406 0.309
Trypanosoma brucei heat shock protein 84, putative 0.0042 0.0089 0.0639
Echinococcus granulosus glycine receptor subunit beta 0.003 0.0046 0.0126
Echinococcus multilocularis GA binding protein alpha chain 0.0069 0.0194 0.0194
Schistosoma mansoni patched 1 0.009 0.0272 0.0519
Loa Loa (eye worm) prolyl oligopeptidase 0.0033 0.0057 0.0108
Onchocerca volvulus 0.0093 0.0285 0.05
Schistosoma mansoni nAChR subunit 0.003 0.0046 0.0088
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0046 0.0126
Loa Loa (eye worm) hypothetical protein 0.011 0.035 0.0666
Giardia lamblia Serine peptidase, putative 0.0025 0.0023 0.0814
Echinococcus granulosus Protein patched homolog 1 0.009 0.0272 0.074
Mycobacterium leprae Probable polyketide synthase Pks1 0.0196 0.0679 0.127
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Brugia malayi Melatonin receptor type 1A 0.0093 0.0285 0.0543
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0025 0.014
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.0285 0.0774
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0124 0.0406 0.0763
Loa Loa (eye worm) hypothetical protein 0.0058 0.0152 0.029
Echinococcus granulosus intermediate filament protein 0.0026 0.0028 0.0076
Echinococcus granulosus alpha 1A adrenergic receptor 0.0093 0.0285 0.0774
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0093 0.0285 0.0543
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0358 0.1301 0.2479
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0093 0.0285 0.0774
Loa Loa (eye worm) hypothetical protein 0.0092 0.0284 0.0541
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0021 0.0111
Plasmodium vivax endoplasmin, putative 0.0075 0.0215 0.3358
Schistosoma mansoni SET domain protein 0.0034 0.0058 0.0111
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0206 0.0381
Brugia malayi beta-lactamase 0.0072 0.0206 0.0393
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0209 0.0729 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0118 0.0865
Giardia lamblia Heat shock protein HSP 90-alpha 0.0062 0.0167 0.7687
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0044 0.0083
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0206 0.251
Brugia malayi jmjC domain containing protein 0.0024 0.0021 0.004
Echinococcus granulosus endoplasmin 0.0066 0.0181 0.0491
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.003 0.0046 0.0046
Schistosoma mansoni biogenic amine receptor 0.0093 0.0285 0.0543
Plasmodium falciparum JmjC domain-containing protein, putative 0.0024 0.0021 0.0105
Echinococcus multilocularis protein dispatched 1 0.0102 0.0321 0.0321
Plasmodium falciparum basic transcription factor 3b, putative 0.0033 0.0057 0.0708
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Mycobacterium tuberculosis Probable peptidase 0.0033 0.0057 0.0096
Brugia malayi CHE-14 protein 0.009 0.0272 0.0519
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0057 0.0694
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0046 0.0088
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0025 0.0023 0.0045
Echinococcus multilocularis neuropeptide receptor 0.0093 0.0285 0.0285
Brugia malayi Ets-domain containing protein 0.0069 0.0194 0.0369
Echinococcus multilocularis g protein coupled receptor 0.0093 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0627 0.2332 0.4444
Trypanosoma cruzi heat shock protein 85, putative 0.0062 0.0167 0.124
Brugia malayi mbt repeat family protein 0.0045 0.0104 0.0197
Schistosoma mansoni growth hormone secretagogue receptor 0.0093 0.0285 0.0543
Toxoplasma gondii type I fatty acid synthase, putative 0.0196 0.0679 0.127
Schistosoma mansoni hypothetical protein 0.0276 0.0988 0.1882
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0166 0.0566 0.1079
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0057 0.0108
Plasmodium falciparum amino acid transporter, putative 0.0166 0.0566 0.9238
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0015 0.0065
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0196 0.0679 0.1284
Echinococcus multilocularis muscleblind protein 0.0484 0.1785 0.1785
Loa Loa (eye worm) carboxylesterase 0.0071 0.02 0.0381
Schistosoma mansoni nAChR subunit 0.003 0.0046 0.0088
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0036 0.004
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0048 0.0048
Plasmodium vivax heat shock protein 86, putative 0.0075 0.0215 0.3358
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0023 0.0235
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0024 0.0021 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0048 0.0092
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0206 0.0381
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.003 0.0046 0.0126
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Echinococcus multilocularis neuropeptide receptor A26 0.0531 0.1964 0.1964
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0288 0.1032 0.792
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0202 0.1513
Brugia malayi sulfakinin receptor protein 0.0093 0.0285 0.0543
Echinococcus multilocularis geminin 0.0161 0.0548 0.0548
Loa Loa (eye worm) heat shock protein 75 0.0042 0.0089 0.017
Schistosoma mansoni tar DNA-binding protein 0.006 0.0161 0.0306
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0285 0.0285
Trichomonas vaginalis heat shock protein, putative 0.0062 0.0167 0.2015
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0093 0.0285 0.0285
Echinococcus granulosus biogenic amine 5HT receptor 0.0457 0.1682 0.457
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0021 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.0285 0.0774
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0166 0.0566 0.1054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.004
Brugia malayi hypothetical protein 0.0093 0.0285 0.0543
Echinococcus granulosus expressed conserved protein 0.0196 0.068 0.1848
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0046 0.0106 0.0201
Mycobacterium ulcerans short-chain dehydrogenase 0.0196 0.0679 0.1284
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.02 0.0381
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0046 0.0088
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0025 0.0023 0.0213
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0102 0.032 0.061
Brugia malayi RNA binding protein 0.006 0.0161 0.0306
Onchocerca volvulus 0.0026 0.0028 0.0008
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0036 0.0036
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0082 0.0156
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Plasmodium falciparum flap endonuclease 1 0.0025 0.0025 0.0162
Mycobacterium tuberculosis Possible dehydrogenase 0.0196 0.0679 0.1284
Echinococcus multilocularis serotonin receptor 0.0457 0.1682 0.1682
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0093 0.0285 0.0543
Mycobacterium tuberculosis Conserved protein 0.0072 0.0206 0.0381
Trypanosoma brucei prolyl endopeptidase 0.0033 0.0057 0.0387
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0093 0.0285 0.0543
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0021 0.0116
Schistosoma mansoni sodium-dependent amino acid transporter 0.0166 0.0566 0.1079
Echinococcus multilocularis expressed conserved protein 0.0196 0.068 0.068
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Trypanosoma cruzi heat shock protein 85, putative 0.0075 0.0215 0.1614
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0048 0.0091
Leishmania major hypothetical protein, conserved 0.0071 0.0202 0.1513
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0052 0.0128 0.0128
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0196 0.0679 1
Mycobacterium ulcerans oxidoreductase FadB5 0.0196 0.0679 0.1284
Leishmania major hypothetical protein, conserved 0.0024 0.0021 0.0116
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0023 0.0213
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0057 0.0694
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0206 0.0393
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0166 0.0566 0.0566
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0042 0.0089 0.0089
Onchocerca volvulus 0.0079 0.0233 0.0401
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0196 0.0679 0.1284
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0033 0.0057 0.008
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0166 0.0566 0.1079
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0034 0.0094
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.004 0.0082 0.0156
Brugia malayi hypothetical protein 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0166 0.0566 0.1079
Echinococcus granulosus tm gpcr rhodopsin 0.0956 0.3594 0.9764
Leishmania major heat shock protein, putative 0.0042 0.0089 0.0639
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0033 0.0057 0.0387
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0023 0.0213
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0055 0.0077
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.003 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0048 0.0092
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0028 0.0053
Brugia malayi beta-lactamase family protein 0.0072 0.0206 0.0393
Leishmania major quinone oxidoreductase-like protein,alcohol dehydrogenase, zinc-containing-like protein 0.0071 0.0202 0.1513
Onchocerca volvulus 0.0093 0.0285 0.05
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0048 0.0132
Schistosoma mansoni hypothetical protein 0.0086 0.026 0.0496
Schistosoma mansoni transient receptor potential channel 4 0.0092 0.0284 0.0541
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0285 0.0285
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.003 0.0046 0.0088
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.003 0.0046 0.0046
Schistosoma mansoni amine GPCR 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0124 0.0406 0.0775
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0141 0.0469 0.0867
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0206 0.0381
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Leishmania major basic transcription factor 3a, putative 0.0033 0.0057 0.0391
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0023 0.0213
Brugia malayi Cation transporter family protein 0.01 0.0312 0.0594
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0093 0.0285 0.0543
Mycobacterium tuberculosis Conserved protein 0.0072 0.0206 0.0381
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0036 0.0068
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.003 0.0046 0.0126
Brugia malayi TAR-binding protein 0.006 0.0161 0.0306
Echinococcus multilocularis neuropeptides capa receptor 0.0093 0.0285 0.0285
Loa Loa (eye worm) ACC-1 protein 0.003 0.0046 0.0088
Echinococcus multilocularis muscleblind protein 1 0.0484 0.1785 0.1785
Schistosoma mansoni neuropeptide receptor 0.0093 0.0285 0.0543
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0046 0.0088
Echinococcus granulosus muscleblind protein 0.0484 0.1785 0.4848
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Schistosoma mansoni sex comb on midleg homolog 0.0045 0.0104 0.0197
Echinococcus granulosus neuropeptides capa receptor 0.0093 0.0285 0.0774
Loa Loa (eye worm) hypothetical protein 0.0072 0.0206 0.0393
Onchocerca volvulus 0.0093 0.0285 0.05
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0033 0.0057 0.0387
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0208 0.0726 0.556
Echinococcus granulosus GA binding protein alpha chain 0.0069 0.0194 0.0526
Brugia malayi jmjC domain containing protein 0.0147 0.0493 0.0939
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0285 0.0543
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0124 0.0406 0.0775
Echinococcus multilocularis carboxylesterase 5A 0.0071 0.02 0.02
Echinococcus granulosus jumonji domain containing 1A 0.0024 0.0021 0.0057
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0208 0.0726 0.556
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0196 0.0679 0.1294
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0048 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0048 0.0092
Loa Loa (eye worm) transcription factor SMAD2 0.0253 0.0899 0.1712
Echinococcus granulosus survival motor neuron protein 1 0.0225 0.0792 0.2153
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0055 0.0055
Leishmania major mitochondrial DNA polymerase beta 0.0288 0.1032 0.792
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0196 0.0679 0.9316
Brugia malayi prolyl oligopeptidase family protein 0.028 0.1001 0.1907
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0057 0.0694
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0285 0.0543
Brugia malayi nuclear receptor NHR-88 0.0031 0.0048 0.0092
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0093 0.0285 0.05
Trichomonas vaginalis heat shock protein, putative 0.0075 0.0215 0.2622
Schistosoma mansoni hypothetical protein 0.0076 0.0222 0.0422
Brugia malayi Serotonin receptor 0.0093 0.0285 0.0543
Onchocerca volvulus 0.01 0.0312 0.0552
Brugia malayi hypothetical protein 0.0093 0.0285 0.0543
Echinococcus granulosus dro:myosuppressin receptor 0.0093 0.0285 0.0774
Loa Loa (eye worm) neuropeptide F receptor 0.0093 0.0285 0.0543
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0071 0.0202 0.0386
Echinococcus granulosus lysine specific demethylase 6a 0.0024 0.0021 0.0057
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0025 0.0019
Echinococcus granulosus g-protein coupled receptor 0.0093 0.0285 0.0774
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0055 0.0105
Plasmodium vivax amine transporter, putative 0.0166 0.0566 0.9238
Plasmodium vivax heat shock protein 90, putative 0.0042 0.0089 0.1245
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0033 0.0057 0.0096
Loa Loa (eye worm) hypothetical protein 0.01 0.0314 0.0599
Echinococcus multilocularis short transient receptor potential channel 6 0.0061 0.0164 0.0164
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0166 0.0566 0.1079
Mycobacterium ulcerans heat shock protein 90 0.0066 0.0181 0.0333
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0048 0.0091
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0092
Trypanosoma cruzi oxidoreductase, putative 0.0196 0.0679 0.5198
Echinococcus granulosus peptide allatostatin:somatostatin 0.0093 0.0285 0.0774
Trichomonas vaginalis endoplasmin, putative 0.0051 0.0124 0.1471
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0208 0.0726 0.0726
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0057 0.0629
Trypanosoma brucei heat shock protein, putative 0.0075 0.0215 0.1614
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0196 0.0679 0.1284
Loa Loa (eye worm) hypothetical protein 0.0033 0.0057 0.0108
Brugia malayi N-terminal motif family protein 0.0211 0.0736 0.1403
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.0285 0.0774
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0068
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0208 0.0726 0.556
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0006 0.0006
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0059 0.0155 0.0296
Loa Loa (eye worm) hypothetical protein 0.0072 0.0206 0.0393
Echinococcus multilocularis glycine receptor subunit beta 0.003 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Schistosoma mansoni nAChR subunit 0.003 0.0046 0.0088
Onchocerca volvulus 0.0093 0.0285 0.05
Trypanosoma brucei transcription factor BTF3, putative 0.0033 0.0057 0.0391
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0025 0.014
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0093 0.0285 0.0543
Leishmania major oxidoreductase-like protein 0.0196 0.0679 0.5198
Echinococcus granulosus transient receptor potential ion channel A 0.0089 0.0272 0.0739
Entamoeba histolytica hypothetical protein 0.0033 0.0057 0.0701
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0206 0.251
Schistosoma mansoni biogenic amine receptor 0.0093 0.0285 0.0543
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.003 0.0046 0.0088
Loa Loa (eye worm) serotonin transporter b 0.0979 0.3681 0.7014
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0055 0.0376
Schistosoma mansoni neuropeptide f receptor 76f 0.0093 0.0285 0.0543
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0048 0.0132
Loa Loa (eye worm) hypothetical protein 0.0166 0.0566 0.1079
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.003 0.0046 0.0046
Onchocerca volvulus 0.0031 0.0048 0.0046
Echinococcus granulosus orexin receptor type 2 0.0093 0.0285 0.0774
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0196 0.0679 0.9316
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Loa Loa (eye worm) hypothetical protein 0.0183 0.063 0.1201
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0024 0.0021 0.0113
Onchocerca volvulus 0.0627 0.2332 0.4419
Trypanosoma cruzi heat shock protein 85, putative 0.0075 0.0215 0.1614
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0166 0.0566 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0166 0.0566 0.1539
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0048 0.0132
Schistosoma mansoni nAChR subunit 0.003 0.0046 0.0088
Trypanosoma cruzi oxidoreductase, putative 0.0071 0.0202 0.1513
Leishmania major hypothetical protein, conserved 0.0072 0.0206 0.1544
Onchocerca volvulus Huntingtin homolog 0.0117 0.0377 0.0676
Loa Loa (eye worm) alcohol dehydrogenase class III 0.1388 0.5248 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0166 0.0566 0.1079
Brugia malayi Transient-receptor-potential like protein 0.0034 0.0061 0.0117
Schistosoma mansoni opsin-like receptor 0.0093 0.0285 0.0543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0048 0.0092
Trypanosoma cruzi heat shock protein, putative 0.0042 0.0089 0.0639
Echinococcus multilocularis neuropeptide Y receptor 0.0093 0.0285 0.0285
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0196 0.0679 0.1284
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0021 0.0013
Brugia malayi hypothetical protein 0.0093 0.0285 0.0543
Echinococcus multilocularis sodium and chloride dependent glycine 0.0166 0.0566 0.0566
Entamoeba histolytica transcription factor BTF3, putative 0.0033 0.0057 0.0701
Echinococcus granulosus neuropeptide receptor 0.0093 0.0285 0.0774
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0048 0.0129
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0196 0.0679 0.9316
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.005
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0034 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0045 0.0104 0.0153
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0196 0.0679 0.1846
Trypanosoma cruzi transcription factor btf3, putative 0.0033 0.0057 0.0391
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0196 0.0679 0.1284
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0052 0.0128 0.0347
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0196 0.0679 0.127
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0285 0.0285
Echinococcus granulosus glycine receptor subunit beta 0.003 0.0046 0.0126
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0021 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0057 0.0635
Schistosoma mansoni amine GPCR 0.0093 0.0285 0.0543
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0042 0.0089 0.0242
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.003 0.0046 0.0046
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0206 0.0381
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Schistosoma mansoni histamine h1 receptor 0.0093 0.0285 0.0543
Echinococcus multilocularis acylamino acid releasing enzyme 0.0033 0.0057 0.0057
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0021 0.0116
Brugia malayi Niemann-Pick C1 protein precursor 0.0209 0.0729 0.1389
Loa Loa (eye worm) prolyl oligopeptidase 0.028 0.1001 0.1907
Brugia malayi RNA recognition motif domain containing protein 0.006 0.0161 0.0306
Brugia malayi putative neuropeptide receptor 0.0093 0.0285 0.0543
Mycobacterium ulcerans hypothetical protein 0.0152 0.051 0.0961
Brugia malayi Pre-SET motif family protein 0.0031 0.0048 0.0091
Leishmania major hypothetical protein, conserved 0.0024 0.0021 0.0113
Schistosoma mansoni jumonji/arid domain-containing protein 0.0093 0.0286 0.0545
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.1388 0.5248 1
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.1388 0.5248 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0196 0.0679 0.8447
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0166 0.0566 0.1539
Schistosoma mansoni biogenic amine (5HT) receptor 0.0457 0.1682 0.3206
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0196 0.0679 0.1294
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0071 0.0202 0.0374
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0166 0.0566 0.1539
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0034 0.0093
Schistosoma mansoni hypothetical protein 0.0086 0.026 0.0496
Echinococcus granulosus sex peptide receptor 0.0093 0.0285 0.0774
Trypanosoma brucei heat shock protein 90, putative 0.0075 0.0215 0.1614
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0206 0.1544
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0152 0.029
Echinococcus granulosus L aminoadipate semialdehyde 0.0079 0.0233 0.0633
Loa Loa (eye worm) hypothetical protein 0.0025 0.0023 0.0045
Entamoeba histolytica heat shock protein 90, putative 0.0075 0.0215 0.2892
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0046 0.0088
Plasmodium falciparum transporter, putative 0.0166 0.0566 0.9238
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.003 0.0046 0.0088
Loa Loa (eye worm) hypothetical protein 0.0033 0.0057 0.0108
Loa Loa (eye worm) hypothetical protein 0.0079 0.0233 0.0444
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0196 0.0679 0.5198
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0152 0.029
Giardia lamblia Grp94/Hsp90 0.0066 0.0181 0.8352
Brugia malayi jmjC domain containing protein 0.0024 0.0021 0.004
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0136 0.0451 0.3435
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0048 0.0048
Schistosoma mansoni jumonji domain containing protein 0.0128 0.0421 0.0802
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0023 0.0213
Echinococcus granulosus flap endonuclease 1 0.0025 0.0025 0.0067
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0206 0.0381
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0034 0.0034
Echinococcus granulosus heat shock protein 90 0.0062 0.0167 0.0454
Loa Loa (eye worm) hypothetical protein 0.01 0.0312 0.0594
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0196 0.0679 0.1284
Echinococcus granulosus neuropeptide Y receptor 0.0093 0.0285 0.0774
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0062 0.0167 0.0454
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0048 0.0092
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0025 0.0023 0.0131
Schistosoma mansoni flap endonuclease-1 0.0022 0.0015 0.0029
Loa Loa (eye worm) ACC-1 protein 0.003 0.0046 0.0088
Onchocerca volvulus Fatty acid synthase homolog 0.0124 0.0406 0.0733
Toxoplasma gondii heat shock protein HSP90 0.0075 0.0215 0.0383
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0166 0.0566 0.0566
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.003 0.0046 0.0088
Loa Loa (eye worm) hypothetical protein 0.0211 0.0736 0.1403
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.004 0.0084 0.0603
Echinococcus multilocularis heat shock protein 90 0.0075 0.0215 0.0215
Leishmania major d-xylulose reductase, putative 0.0196 0.0679 0.5198
Echinococcus granulosus g protein coupled receptor 0.0093 0.0285 0.0774
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0196 0.0679 0.5198
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0093 0.0285 0.0543
Brugia malayi Fli-1 protein 0.0209 0.0732 0.1395
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0093 0.0285 0.0774
Brugia malayi hypothetical protein 0.0225 0.0792 0.151
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0055 0.0675
Brugia malayi Cation transporter family protein 0.003 0.0046 0.0088
Loa Loa (eye worm) hypothetical protein 0.0225 0.0792 0.151
Leishmania major oligopeptidase b 0.0033 0.0057 0.0387
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0222 0.0422
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.003 0.0046 0.0088
Brugia malayi Carboxylesterase family protein 0.0071 0.02 0.0381
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0166 0.0566 0.1079
Echinococcus multilocularis neuropeptide receptor 0.0093 0.0285 0.0285
Echinococcus granulosus neuropeptide receptor 0.0093 0.0285 0.0774
Leishmania major hypothetical protein, conserved 0.0071 0.0202 0.1513
Leishmania major nuclear receptor binding factor-like protein 0.0124 0.0406 0.309
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0285 0.0285
Echinococcus multilocularis fmrfamide receptor 0.0093 0.0285 0.0285
Trichomonas vaginalis heat shock protein, putative 0.0066 0.0181 0.219
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0096 0.0184
Echinococcus granulosus tm gpcr rhodopsin 0.0093 0.0285 0.0774
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0093 0.0285 0.0285
Brugia malayi Serine protease Z688.6 precursor 0.0025 0.0023 0.0045
Echinococcus multilocularis transient receptor potential ion channel A 0.0089 0.0272 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0048 0.0092
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0485 0.1789 0.1789
Echinococcus granulosus allatostatin A receptor 0.0093 0.0285 0.0774
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.01 0.0312 0.0594
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.003 0.0046 0.0126
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0057 0.0108
Echinococcus multilocularis protein patched 0.009 0.0272 0.0272
Trypanosoma brucei oxidoreductase, putative 0.0196 0.0679 0.5198
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0206 0.0393
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0033 0.0057 0.0387
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0179 0.0615 0.0615
Echinococcus granulosus somatostatin receptor 0.0093 0.0285 0.0774
Echinococcus multilocularis dnaJ subfamily B 0.039 0.1422 0.1422
Echinococcus granulosus serotonin transporter 0.0979 0.3681 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0093 0.0285 0.0285
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0025 0.0023 0.0017
Echinococcus multilocularis phd:f box containing protein 0.0024 0.0021 0.0021
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0057 0.0108
Loa Loa (eye worm) hypothetical protein 0.0072 0.0206 0.0393
Loa Loa (eye worm) hypothetical protein 0.0209 0.0729 0.1389
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.006 0.0161 0.0306
Toxoplasma gondii ABC1 family protein 0.0072 0.0206 0.0366
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0042 0.0089 0.1145
Onchocerca volvulus 0.0093 0.0285 0.05
Echinococcus multilocularis neuropeptide s receptor 0.0531 0.1964 0.1964
Loa Loa (eye worm) jmjC domain-containing protein 0.0093 0.0286 0.0545
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0093 0.0285 0.0543
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0206 0.0393
Echinococcus granulosus prolyl endopeptidase 0.0033 0.0057 0.0154
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0048 0.0092
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.003 0.0046 0.0088
Echinococcus multilocularis histone acetyltransferase MYST2 0.0052 0.0128 0.0128
Mycobacterium ulcerans quinone oxidoreductase 0.0196 0.0679 0.1284
Giardia lamblia Heat shock protein HSP 90-alpha 0.0075 0.0215 1
Echinococcus granulosus cpg binding protein 0.0064 0.0176 0.0478
Schistosoma mansoni sex comb on midleg homolog 0.0045 0.0104 0.0197
Trypanosoma cruzi heat shock protein 90, putative 0.0062 0.0167 0.124
Schistosoma mansoni zinc binding dehydrogenase 0.0196 0.0679 0.1294
Echinococcus granulosus lamin 0.0026 0.0028 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0285 0.0543
Echinococcus multilocularis allatostatin A receptor 0.0093 0.0285 0.0285
Mycobacterium tuberculosis Conserved protein 0.0072 0.0206 0.0381
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0048 0.0048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0048 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0057 0.0635
Schistosoma mansoni neuropeptide receptor 0.0093 0.0285 0.0543
Loa Loa (eye worm) heat shock protein 90 0.0075 0.0215 0.041
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0093 0.0285 0.0285
Schistosoma mansoni myelin transcription factor 1 myt1 0.0052 0.0128 0.0243
Echinococcus granulosus carboxylesterase 5A 0.0071 0.02 0.0543
Echinococcus granulosus hypothetical protein 0.0812 0.3042 0.8265
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Schistosoma mansoni amine GPCR 0.0093 0.0285 0.0543
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0093 0.0285 0.0543
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0048 0.0132
Schistosoma mansoni hypothetical protein 0.0161 0.0548 0.1044
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Loa Loa (eye worm) endoplasmin 0.0075 0.0215 0.041
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.1388 0.5248 1
Brugia malayi Serine protease Z688.6 precursor 0.0025 0.0023 0.0045
Echinococcus multilocularis cpg binding protein 0.0064 0.0176 0.0176
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.003 0.0046 0.0046
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0196 0.0679 0.1284
Onchocerca volvulus 0.0093 0.0285 0.05
Schistosoma mansoni cpg binding protein 0.0064 0.0176 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0048 0.0092
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0096 0.0184
Trypanosoma cruzi oligopeptidase b 0.0033 0.0057 0.0387
Toxoplasma gondii quinone oxidoreductase, putative 0.0196 0.0679 0.127
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Echinococcus granulosus heat shock protein 90 0.0075 0.0215 0.0585
Onchocerca volvulus 0.0093 0.0285 0.05
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0093 0.0285 0.0543
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0196 0.0679 0.5198
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Loa Loa (eye worm) TYRA-2 protein 0.0093 0.0285 0.0543
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0046 0.0088
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0094
Onchocerca volvulus 0.0196 0.0679 0.1255
Echinococcus multilocularis Niemann Pick C1 protein 0.0209 0.0729 0.0729
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0196 0.0679 0.8447
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0048 0.0092
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0093 0.0285 0.0285
Entamoeba histolytica hypothetical protein 0.0076 0.0222 0.2978
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.003 0.0046 0.0088
Onchocerca volvulus Neuropeptide F receptor homolog 0.0093 0.0285 0.05
Brugia malayi hypothetical protein 0.0108 0.0342 0.0651
Loa Loa (eye worm) hypothetical protein 0.0196 0.0679 0.1294
Brugia malayi heat shock protein 90 0.0075 0.0215 0.041
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0025 0.0025
Mycobacterium ulcerans beta-lactamase 0.0072 0.0206 0.0381
Echinococcus granulosus 7tm_1 domain containing protein 0.0093 0.0285 0.0774
Schistosoma mansoni neuropeptide receptor 0.0093 0.0285 0.0543
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.001 0.0026
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0055 0.0055
Mycobacterium tuberculosis Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.1192 0.4498 0.8569
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.0979 0.3681 0.7014
Echinococcus granulosus sterol regulatory element binding protein 0.009 0.0272 0.074
Schistosoma mansoni heat shock protein 0.0075 0.0215 0.041
Trypanosoma cruzi quinone oxidoreductase, putative 0.0071 0.0202 0.1513
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0096 0.0184
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0057 0.2399
Schistosoma mansoni microtubule-associated protein tau 0.0657 0.2448 0.4664
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0196 0.0679 0.127
Echinococcus multilocularis neuropeptide FF receptor 2 0.0093 0.0285 0.0285
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0057 0.0108
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Loa Loa (eye worm) G-protein coupled receptor 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0053
Loa Loa (eye worm) neuropeptide F receptor 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.004
Mycobacterium ulcerans lipase LipD 0.0072 0.0206 0.0381
Schistosoma mansoni hypothetical protein 0.0093 0.0285 0.0543
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0093 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0034 0.0061 0.0117
Brugia malayi Dopamine receptor protein 1 0.0093 0.0285 0.0543
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0206 0.0381
Brugia malayi Cytochrome P450 family protein 0.0047 0.011 0.021
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0021 0.004
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0212 0.0741 0.1412
Echinococcus multilocularis dro:myosuppressin receptor 0.0093 0.0285 0.0285
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0025 0.0023 0.0131
Onchocerca volvulus 0.0093 0.0285 0.05
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0066 0.0181 0.1348
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Echinococcus multilocularis survival motor neuron protein 1 0.0225 0.0792 0.0792
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Brugia malayi hypothetical protein 0.0166 0.0566 0.1079
Onchocerca volvulus 0.0093 0.0285 0.05
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.004 0.0084 0.0603
Schistosoma mansoni opsin-like receptor 0.0093 0.0285 0.0543
Trypanosoma brucei heat shock protein, putative 0.0075 0.0215 0.1614
Brugia malayi hypothetical protein 0.0093 0.0285 0.0543
Loa Loa (eye worm) acyl carrier protein 0.0124 0.0406 0.0775
Loa Loa (eye worm) hypothetical protein 0.0979 0.3681 0.7014
Schistosoma mansoni tar DNA-binding protein 0.006 0.0161 0.0306
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0315 0.1136 0.2165
Loa Loa (eye worm) histone methyltransferase 0.0021 0.001 0.0018
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0093 0.0285 0.0285
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0075 0.0864
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0048 0.0048
Brugia malayi excitatory GABA receptor EXP-1A 0.003 0.0046 0.0088
Loa Loa (eye worm) hypothetical protein 0.0025 0.0023 0.0045
Echinococcus multilocularis lysine specific demethylase 6a 0.0024 0.0021 0.0021
Brugia malayi beta-lactamase family protein 0.0072 0.0206 0.0393
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0196 0.0679 0.5198
Brugia malayi AKH receptor 0.0093 0.0285 0.0543
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.003 0.0058
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0048 0.0092
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0206 0.251
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.028 0.1001 0.1001
Schistosoma mansoni gabp alpha 0.0069 0.0194 0.0369
Onchocerca volvulus Huntingtin homolog 0.0117 0.0377 0.0676
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0206 0.3208
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0078 0.0078
Schistosoma mansoni protein phosphatase 2C 0.0024 0.0021 0.004
Echinococcus granulosus sodium and chloride dependent glycine 0.0166 0.0566 0.1539
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0093 0.0285 0.0285
Loa Loa (eye worm) TAR-binding protein 0.006 0.0161 0.0306
Echinococcus multilocularis JmjC domain containing protein 4 0.0024 0.0021 0.0021
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0196 0.0679 0.1284
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0025 0.0023 0.0023
Brugia malayi hypothetical protein 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0166 0.0566 0.1079
Schistosoma mansoni transcription factor btf3 0.0033 0.0057 0.0109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0096 0.0096
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0093 0.0285 0.0285
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0023 0.0213
Loa Loa (eye worm) hypothetical protein 0.0025 0.0023 0.0045
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0046 0.0106 0.0201
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0048 0.0048
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Loa Loa (eye worm) hypothetical protein 0.0063 0.0169 0.0322
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0023 0.0213
Echinococcus multilocularis tar DNA binding protein 0.006 0.0161 0.0161
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0222 0.0602
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0079 0.0233 0.0444
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0196 0.0679 0.1284
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0088
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0036 0.0098
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0196 0.0679 0.1284
Loa Loa (eye worm) norepinephrine transporter 0.0979 0.3681 0.7014
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0206 0.0381
Brugia malayi Steroid receptor seven-up type 2 0.0117 0.0376 0.0717
Schistosoma mansoni hypothetical protein 0.0093 0.0285 0.0543
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0055 0.0376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0048 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0057 0.0635
Brugia malayi Flap endonuclease-1 0.0025 0.0025 0.0047
Trypanosoma brucei heat shock protein, putative 0.0075 0.0215 0.1614
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0166 0.0566 0.1079
Loa Loa (eye worm) hypothetical protein 0.01 0.0312 0.0594
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.0285 0.0285
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0048 0.0132
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0093 0.0285 0.0543
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0021 0.0116
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0206 0.0366
Leishmania major quinone oxidoreductase, putative 0.0196 0.0679 0.5198
Trypanosoma brucei oligopeptidase b 0.0033 0.0057 0.0387
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0048 0.0092
Echinococcus granulosus transient receptor potential gamma protein 0.0092 0.0284 0.0771
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0117 0.0376 0.1023
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0055 0.0105
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.003 0.0046 0.0088
Echinococcus multilocularis SAM and MBT domain containing protein 0.0045 0.0104 0.0104
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0048 0.0062
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0025 0.0023 0.0213
Echinococcus granulosus tm gpcr rhodopsin 0.0093 0.0285 0.0774
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Echinococcus granulosus lysine specific demethylase 5A 0.0093 0.0286 0.0778
Trypanosoma brucei prolyl oligopeptidase, putative 0.0033 0.0057 0.0387
Schistosoma mansoni jumonji domain containing protein 0.0024 0.0021 0.004
Loa Loa (eye worm) hypothetical protein 0.0484 0.1785 0.3401
Schistosoma mansoni sodium/chloride dependent transporter 0.0166 0.0566 0.1079
Trypanosoma cruzi heat shock protein 90, putative 0.0075 0.0215 0.1614
Onchocerca volvulus 0.0166 0.0566 0.1039
Echinococcus multilocularis glycine receptor subunit beta 0.003 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.1388 0.5248 1
Entamoeba histolytica hypothetical protein 0.0076 0.0222 0.2978
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0196 0.0679 0.1284
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0093 0.0285 0.0543
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0136 0.0451 0.3435
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0025 0.0023 0.0064
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0048 0.0048
Toxoplasma gondii hypothetical protein 0.0033 0.0057 0.008
Schistosoma mansoni endoplasmin 0.0075 0.0215 0.041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0285 0.0543
Onchocerca volvulus 0.0093 0.0285 0.05
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0093 0.0285 0.0543
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0023 0.0213
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.0076 0.0222 0.2978
Brugia malayi G-protein coupled receptor 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0196 0.0679 0.1294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0048 0.0092
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0179 0.0615 0.1672
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0093 0.0285 0.0285
Mycobacterium ulcerans oxidoreductase 0.0196 0.0679 0.1284
Schistosoma mansoni survival motor neuron protein 0.0046 0.0106 0.0201
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.003 0.0046 0.0126
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0166 0.0566 0.1539
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0006 0.0012
Trypanosoma cruzi prolyl endopeptidase 0.0033 0.0057 0.0387
Mycobacterium ulcerans quinone oxidoreductase 0.0196 0.0679 0.1284
Brugia malayi Serotonin receptor 0.0573 0.2123 0.4046
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0093 0.0285 0.0543
Leishmania major phosphopantetheinyl transferase-like protein 0.0022 0.0015 0.0065
Schistosoma mansoni tar DNA-binding protein 0.006 0.0161 0.0306
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0092
Mycobacterium ulcerans dehydrogenase 0.0196 0.0679 0.1284
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0166 0.0566 0.1079
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0093 0.0285 0.0543
Schistosoma mansoni nAChR subunit 0.003 0.0046 0.0088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0096 0.0262
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0048 0.0092
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0023 0.0213
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0048 0.0092
Onchocerca volvulus 0.0061 0.0163 0.0266
Brugia malayi mbt repeat family protein 0.0045 0.0104 0.0197
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0078 0.0211
Echinococcus granulosus acylamino acid releasing enzyme 0.0033 0.0057 0.0154
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0024 0.0021 0.0113
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0055 0.0675
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.011 0.021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0152 0.029
Trichomonas vaginalis esterase, putative 0.0072 0.0206 0.251
Echinococcus granulosus microtubule associated protein 2 0.0657 0.2448 0.665
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0093 0.0285 0.0285
Echinococcus multilocularis serotonin receptor 0.0457 0.1682 0.1682
Echinococcus multilocularis endoplasmin 0.0066 0.0181 0.0181
Schistosoma mansoni ets-related 0.0209 0.0732 0.1395
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0066 0.0181 0.2499
Schistosoma mansoni transient receptor potential channel 0.0092 0.0284 0.0541
Echinococcus multilocularis transient receptor potential gamma protein 0.0092 0.0284 0.0284
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0033 0.0057 0.0387
Echinococcus granulosus geminin 0.0161 0.0548 0.1488
Echinococcus granulosus g protein coupled receptor 0.0093 0.0285 0.0774
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0057 0.2399
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0048 0.0132
Trypanosoma cruzi oxidoreductase, putative 0.0196 0.0679 0.5198
Loa Loa (eye worm) hypothetical protein 0.0071 0.02 0.0381
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0025 0.0865
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0124 0.1471
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0023 0.0213
Brugia malayi Tachykinin-like peptides receptor 99D 0.0093 0.0285 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0023 0.0213
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.0285 0.0774
Schistosoma mansoni heat shock protein 0.0075 0.0215 0.041
Onchocerca volvulus 0.01 0.0312 0.0552
Entamoeba histolytica heat shock protein 90, putative 0.0075 0.0215 0.2892
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0166 0.0566 0.1079
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0048 0.0048
Schistosoma mansoni sodium/chloride dependent transporter 0.0979 0.3681 0.7014
Echinococcus multilocularis microtubule associated protein 2 0.0657 0.2448 0.2448
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0149 0.0284
Brugia malayi GnHR receptor homolog 0.0093 0.0285 0.0543
Treponema pallidum heat shock protein 90 0.0066 0.0181 0.0453
Trypanosoma brucei oxidoreductase, putative 0.0196 0.0679 0.5198
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0124 0.0406 0.0775
Trypanosoma cruzi oligopeptidase b 0.0033 0.0057 0.0387
Schistosoma mansoni amine GPCR 0.0093 0.0285 0.0543
Brugia malayi G-protein coupled receptor 0.0093 0.0285 0.0543
Loa Loa (eye worm) hypothetical protein 0.0484 0.1785 0.3401
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.003 0.0046 0.0088
Brugia malayi Cation transporter family protein 0.003 0.0046 0.0088
Trypanosoma cruzi quinone oxidoreductase, putative 0.0071 0.0202 0.1513
Brugia malayi Bromodomain containing protein 0.0028 0.0036 0.0068
Schistosoma mansoni biogenic amine receptor 0.0093 0.0285 0.0543
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.009 0.0272 0.0519
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0025 0.0162
Loa Loa (eye worm) hypothetical protein 0.0072 0.0206 0.0393
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0196 0.0679 0.1284
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0048 0.0048
Leishmania major heat shock protein 83-1 0.0075 0.0215 0.1614
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0055 0.0077
Brugia malayi intermediate filament protein 0.0026 0.0028 0.0053
Echinococcus multilocularis G protein coupled receptor 139 0.0093 0.0285 0.0285
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0093 0.0285 0.0774
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.003 0.0046 0.0088
Echinococcus multilocularis serotonin transporter 0.0979 0.3681 0.3681
Entamoeba histolytica hypothetical protein 0.0076 0.0222 0.2978
Echinococcus granulosus polycomb protein SCMH1 0.0045 0.0104 0.0281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0285 0.0543
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0093 0.0285 0.0543
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0196 0.0679 0.1284
Brugia malayi Pre-SET motif family protein 0.0201 0.0698 0.133
Schistosoma mansoni hypothetical protein 0.0093 0.0285 0.0543
Schistosoma mansoni hypothetical protein 0.0161 0.0548 0.1044
Echinococcus granulosus fmrfamide receptor 0.0093 0.0285 0.0774
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0196 0.0679 0.127
Trypanosoma cruzi transcription factor btf3, putative 0.0033 0.0057 0.0391
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0006 0.0012
Echinococcus multilocularis sex peptide receptor 0.0093 0.0285 0.0285
Mycobacterium tuberculosis Probable oxidoreductase 0.0196 0.0679 0.1284
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0092
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0055 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0048 0.0092
Brugia malayi larval opioid receptor 0.0093 0.0285 0.0543
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.0285 0.0543
Echinococcus multilocularis lamin 0.0026 0.0028 0.0028
Echinococcus granulosus nAChR subunit 0.003 0.0046 0.0126
Echinococcus granulosus lamin dm0 0.0026 0.0028 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0096 0.0184
Echinococcus granulosus serotonin receptor 0.0093 0.0285 0.0774
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0057 0.0108
Brugia malayi Ets-domain containing protein 0.0069 0.0194 0.0369
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0021 0.0111
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0048 0.0092
Echinococcus multilocularis peregrin 0.0037 0.0071 0.0071
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0288 0.1032 0.792

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.11 uM Inhibitory concentration against dipeptidyl-peptidase IV ChEMBL. 15908206
IC50 (binding) = 0.11 uM Inhibitory concentration against dipeptidyl-peptidase IV ChEMBL. 15908206
IC50 (binding) = 90 uM Inhibitory concentration against dipeptidyl-peptidase II (QPP) ChEMBL. 15908206
IC50 (binding) = 90 uM Inhibitory concentration against dipeptidyl-peptidase II (QPP) ChEMBL. 15908206
IC50 (binding) > 100 uM Inhibitory concentration against dipeptidyl-peptidase 8 ChEMBL. 15908206
IC50 (binding) > 100 uM Inhibitory concentration against dipeptidyl-peptidase 9 ChEMBL. 15908206
IC50 (binding) > 100 uM Inhibitory concentration against dipeptidyl-peptidase 8 ChEMBL. 15908206
IC50 (binding) > 100 uM Inhibitory concentration against dipeptidyl-peptidase 9 ChEMBL. 15908206

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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