Detailed information for compound 1445857

Basic information

Technical information
  • TDR Targets ID: 1445857
  • Name: CAS-427-51-0
  • MW: 416.938 | Formula: C24H29ClO4
  • H donors: 0 H acceptors: 3 LogP: 3.64 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)O[C@@]1(CC[C@H]2[C@@]1(C)CC[C@H]1[C@H]2C=C(C2=CC(=O)[C@@H]3[C@@H]([C@]12C)C3)Cl)C(=O)C
  • InChi: 1S/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14-,15-,16+,17-,18-,22+,23-,24-/m0/s1
  • InChiKey: UWFYSQMTEOIJJG-KDUXJDSCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NCGC00016443-01
  • Lopac-C-3412
  • NCGC00015230-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0341 0.0324 0.0487
Plasmodium vivax SET domain protein, putative 0.0032 0.0009 0.0345
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0042 0.0042
Onchocerca volvulus 0.0156 0.0136 0.0223
Echinococcus granulosus calcium transporting atpase 0.0162 0.0142 0.0142
Schistosoma mansoni hypothetical protein 0.0717 0.0705 0.1815
Plasmodium falciparum flap endonuclease 1 0.0028 0.0005 0.0233
Trichomonas vaginalis helicase, putative 0.0026 0.0004 0.0088
Schistosoma mansoni inositol monophosphatase 0.0121 0.01 0.0257
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.0035 0.0653
Plasmodium falciparum glutathione reductase 0.0057 0.0035 0.1538
Loa Loa (eye worm) isocitrate dehydrogenase 0.005 0.0028 0.0042
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0138 0.0118 0.2285
Schistosoma mansoni cpg binding protein 0.0114 0.0093 0.024
Mycobacterium tuberculosis Conserved protein 0.0156 0.0136 0.0345
Mycobacterium ulcerans metal cation transporter p-type ATPase, CtpV 0.0031 0.0009 0.0018
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.0028 0.054
Schistosoma mansoni atpase class VI type 11c 0.0025 0.0003 0.0007
Toxoplasma gondii aldehyde dehydrogenase 0.0179 0.0159 0.6931
Trypanosoma cruzi DNA damage repair protein, putative 0.0057 0.0035 0.0668
Trichomonas vaginalis aldehyde oxidase, putative 0.0352 0.0335 0.8361
Echinococcus granulosus acetylcholinesterase 0.0132 0.0112 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.021 0.0191 0.3703
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0054 0.1336
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0828 0.0819 0.0819
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.012 0.035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0722 0.071 0.1069
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0059 0.0037 0.0095
Loa Loa (eye worm) transcription factor SMAD2 0.0361 0.0344 0.0517
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0041 0.0019 0.0718
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0124 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0126 0.0106 0.0159
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.0071 0.0071
Schistosoma mansoni cation-transporting atpase worm 0.0031 0.0009 0.0024
Plasmodium falciparum phospholipid-transporting ATPase, putative 0.0036 0.0014 0.0614
Schistosoma mansoni hypothetical protein 0.0228 0.0209 0.0538
Brugia malayi conserved hypotetical protein 0.006 0.0038 0.0057
Loa Loa (eye worm) matrix metalloproteinase 0.2714 0.2734 0.4116
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0054 0.2007
Echinococcus granulosus GPCR family 2 0.0228 0.0209 0.0209
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0075 0.0054 0.1035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.0313 0.0805
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0133 0.0112 0.2798
Onchocerca volvulus 0.0054 0.0032 0.0053
Trichomonas vaginalis bromodomain-containing protein, putative 0.0092 0.0071 0.1768
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0042 0.002 0.0051
Leishmania major calcium motive p-type ATPase, putative 0.0162 0.0142 0.2752
Brugia malayi Cytochrome P450 family protein 0.0032 0.0009 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0004 0.0088
Brugia malayi calcium ATPase 0.008 0.0059 0.0088
Schistosoma mansoni hypothetical protein 0.033 0.0312 0.0804
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0271 0.6758
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0121 0.01 0.0291
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0157 0.0137 0.3413
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0031 0.0009 0.0172
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Schistosoma mansoni nuclear hormone receptor 0.0126 0.0106 0.0272
Echinococcus granulosus mitogen activated protein kinase 11 0.0138 0.0118 0.0118
Schistosoma mansoni polycystin 1-related 0.0357 0.034 0.0874
Brugia malayi nuclear hormone receptor 0.006 0.0038 0.0057
Schistosoma mansoni apoferritin-2 0.0026 0.0003 0.0008
Trypanosoma brucei calcium-transporting ATPase, putative 0.0103 0.0082 0.1573
Echinococcus granulosus lamin 0.0033 0.001 0.001
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.005 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0032 0.001 0.0015
Trypanosoma brucei calcium-transporting ATPase, putative 0.0036 0.0014 0.025
Loa Loa (eye worm) hypothetical protein 0.0041 0.0019 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.0313 0.0805
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0121 0.01 0.2497
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0126 0.0106 0.0159
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0036 0.0014 0.0351
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.0028 0.054
Treponema pallidum quinoline 2-oxidoreductase 0.0056 0.0034 0.116
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0126 0.0106 0.0272
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0157 0.0137 0.2657
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0162 0.0142 0.0213
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0246 0.0227 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0032 0.0809
Echinococcus granulosus cation transporting ATPase 13A1 0.0031 0.0009 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0 0.0009
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0007 0.0007
Loa Loa (eye worm) nuclear receptor NHR-67 0.006 0.0038 0.0057
Loa Loa (eye worm) hypothetical protein 0.0132 0.0112 0.0168
Loa Loa (eye worm) CHromoDomain protein family member 0.0029 0.0007 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0004 0.0088
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0064 0.0042 0.1823
Schistosoma mansoni hypothetical protein 0.3849 0.3886 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.0106 0.0159
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0162 0.0142 0.2752
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0025 0.0067
Schistosoma mansoni cation-transporting ATPase 0.0031 0.0009 0.0024
Brugia malayi ecdysteroid receptor 0.0126 0.0106 0.0159
Mycobacterium ulcerans hypothetical protein 0.0192 0.0172 0.0508
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.033 0.0312 0.0312
Trypanosoma brucei unspecified product 0.0126 0.0105 0.2022
Trichomonas vaginalis cation-transporting ATPase, putative 0.0036 0.0014 0.0351
Loa Loa (eye worm) hypothetical protein 0.0067 0.0045 0.0068
Onchocerca volvulus Matrilysin homolog 0.2714 0.2734 0.4488
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0013 0.0197
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0269 0.6722
Brugia malayi hypothetical protein 0.0474 0.0458 0.069
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0108 0.0087 0.0252
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0045 0.0067
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0076 0.0076
Schistosoma mansoni ferritin 0.0026 0.0003 0.0008
Toxoplasma gondii ABC1 family protein 0.0156 0.0136 0.592
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0025 0.0487
Loa Loa (eye worm) hypothetical protein 0.0156 0.0136 0.0204
Echinococcus granulosus lamin dm0 0.0033 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0057
Loa Loa (eye worm) hypothetical protein 0.0156 0.0136 0.0204
Brugia malayi Inositol-1 0.0121 0.01 0.0151
Mycobacterium ulcerans monoamine oxidase 0.0041 0.0019 0.0049
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0054 0.1336
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0067 0.0046 0.0127
Trypanosoma cruzi phospholipid-transporting ATPase 1-like protein, putative 0.0036 0.0014 0.0267
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0061 0.1525
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0179 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0103 0.0082 0.0123
Trichomonas vaginalis inositol monophosphatase, putative 0.0121 0.01 0.2497
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0182 0.0162 0.0418
Brugia malayi Importin beta-1 subunit 0.0028 0.0006 0.0009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0126 0.0106 0.0106
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0119 0.0098 0.0285
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0019 0.0042
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0153 0.2965
Trichomonas vaginalis D-aminoacylase, putative 0.0156 0.0136 0.3388
Schistosoma mansoni ferritin 0.0026 0.0003 0.0008
Mycobacterium leprae conserved hypothetical protein 0.0042 0.002 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.021 0.0191 0.3703
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0172 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0295 0.0277 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0126 0.0106 0.0159
Loa Loa (eye worm) beta-lactamase 0.0156 0.0136 0.0204
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0092 0.0071 0.2622
Brugia malayi Smad1 0.0025 0.0002 0.0003
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0153 0.2954
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0269 0.6722
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0156 0.0136 0.0204
Brugia malayi Latrophilin receptor protein 2 0.0228 0.0209 0.0315
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0054 0.1034
Loa Loa (eye worm) hypothetical protein 0.0156 0.0136 0.0204
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0126 0.0106 0.0106
Echinococcus multilocularis chromobox protein 1 0.0137 0.0116 0.0116
Mycobacterium leprae PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB 0.0031 0.0009 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.021 0.0191 0.3703
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0036 0.0014 0.0351
Leishmania major copper-transporting ATPase-like protein, putative 0.0031 0.0009 0.0172
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0157 0.0137 0.2644
Giardia lamblia DNA damage repair protein 0.0057 0.0035 0.0725
Treponema pallidum hypothetical protein 0.0057 0.0035 0.1211
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0075 0.0114
Loa Loa (eye worm) hypothetical protein 0.0051 0.0029 0.0044
Brugia malayi orphan nuclear receptor NR2E1 0.006 0.0038 0.0057
Echinococcus granulosus ferritin 0.0026 0.0003 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0007 0.0018
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.006 0.0038 0.0097
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0041 0.0786
Schistosoma mansoni hypothetical protein 0.0228 0.0209 0.0538
Brugia malayi Pre-SET motif family protein 0.0032 0.0009 0.0014
Echinococcus multilocularis mitogen activated protein kinase 14 0.0138 0.0118 0.0118
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0179 0.0159 0.0159
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0157 0.0137 0.3413
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0528 0.0514 1
Toxoplasma gondii isocitrate dehydrogenase 0.005 0.0028 0.1225
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.017 0.4239
Trypanosoma cruzi phospholipid-translocating ATPase, putative 0.0036 0.0014 0.0267
Loa Loa (eye worm) hypothetical protein 0.0074 0.0052 0.0079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0126 0.0106 0.0272
Brugia malayi Na,K-ATPase alpha subunit 0.0436 0.042 0.0632
Trypanosoma brucei DNA polymerase eta, putative 0.024 0.0221 0.4287
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0417 0.0401 0.0401
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0025 0.0487
Echinococcus granulosus neuropeptide s receptor 0.0573 0.0559 0.0559
Loa Loa (eye worm) hypothetical protein 0.0032 0.001 0.0015
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0054 0.2366
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0025 0.0058
Echinococcus multilocularis chromobox protein 1 0.0137 0.0116 0.0116
Echinococcus granulosus dnaJ subfamily B 0.1626 0.1629 0.1629
Trypanosoma brucei phospholipid-translocating ATPase, putative 0.0036 0.0014 0.025
Trichomonas vaginalis CAMK family protein kinase 0.0417 0.0401 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Schistosoma mansoni tsg101-related 0.0062 0.004 0.0102
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0138 0.0118 0.2285
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0157 0.0137 0.2657
Trichomonas vaginalis importin beta-1, putative 0.0023 0 0.0009
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.005 0.0028 0.0072
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0009 0.0406
Loa Loa (eye worm) hypothetical protein 0.0106 0.0085 0.0128
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.0158 0.0259
Brugia malayi MH1 domain containing protein 0.0025 0.0002 0.0003
Toxoplasma gondii isocitrate dehydrogenase 0.005 0.0028 0.1225
Echinococcus granulosus phospholipid transporting ATPase IF 0.0036 0.0014 0.0014
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0157 0.0137 0.0137
Plasmodium falciparum protoporphyrinogen oxidase 0.0041 0.0019 0.0846
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0029 0.0007 0.0007
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0147 0.0126 0.2994
Loa Loa (eye worm) hypothetical protein 0.0264 0.0245 0.0369
Echinococcus multilocularis snurportin 1 0.03 0.0282 0.0282
Echinococcus granulosus survival motor neuron protein 1 0.0474 0.0458 0.0458
Echinococcus multilocularis acetylcholinesterase 0.0132 0.0112 0.0112
Echinococcus multilocularis mitogen activated protein kinase 3 0.0075 0.0054 0.0054
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0231 0.0212 0.051
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0172 0.0152 0.0152
Schistosoma mansoni carbonic anhydrase 0.0248 0.0229 0.059
Schistosoma mansoni hypothetical protein 0.0228 0.0209 0.0538
Brugia malayi latrophilin 2 splice variant baaae 0.0493 0.0478 0.072
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.008 0.0059 0.0088
Loa Loa (eye worm) hypothetical protein 0.0042 0.002 0.003
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0313 0.0295 0.0295
Plasmodium falciparum calcium-transporting ATPase 0.0162 0.0142 0.6178
Schistosoma mansoni transient receptor potential channel 0.0063 0.0042 0.0107
Loa Loa (eye worm) heterochromatin protein 1 0.0137 0.0116 0.0175
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0031 0.0009 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.002 0.0504
Echinococcus granulosus chromobox protein 1 0.0137 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0717 0.0705 0.1815
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0352 0.0335 0.8361
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0019 0.0706
Brugia malayi chromobox protein homolog 3 0.0077 0.0055 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0126 0.0106 0.0159
Trichomonas vaginalis set domain proteins, putative 0.0233 0.0214 0.5344
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0014 0.0021
Echinococcus multilocularis Nuclear hormone receptor HR96 0.006 0.0038 0.0038
Schistosoma mansoni chromobox protein 0.0137 0.0116 0.0299
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0006 0.0006
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Echinococcus multilocularis nuclear receptor nhr 48 0.006 0.0038 0.0038
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.0282 0.0424
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0362 0.0345 0.1026
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0025 0.0487
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0031 0.0009 0.0401
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0000000000020276 0.000000000050622
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0056
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Schistosoma mansoni transmemberane protein 0.0828 0.0819 0.2106
Plasmodium falciparum histone acetyltransferase GCN5 0.0084 0.0063 0.2751
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0172 0.0152 0.0446
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0004 0.0088
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0528 0.0514 0.0773
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0124 0.0364
Brugia malayi E1-E2 ATPase family protein 0.0105 0.0084 0.0127
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0013 0.002
Brugia malayi jmjC domain containing protein 0.006 0.0038 0.0057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.0159 0.0467
Echinococcus granulosus cpg binding protein 0.0121 0.01 0.01
Schistosoma mansoni lamin 0.0033 0.001 0.0027
Brugia malayi SWIRM domain containing protein 0.0041 0.0019 0.0029
Echinococcus granulosus Na:K ATPase alpha subunit 0.0426 0.041 0.041
Schistosoma mansoni smad1 5 8 and 0.0025 0.0002 0.0006
Brugia malayi TAR-binding protein 0.0133 0.0113 0.017
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0231 0.0212 0.0628
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0113 0.029
Brugia malayi MH2 domain containing protein 0.0361 0.0344 0.0517
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0228 0.0209 0.0209
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0054 0.2366
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.0348 0.6762
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.0193 0.4827
Brugia malayi calcium ATPase 0.0082 0.006 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0156 0.0136 0.2637
Echinococcus granulosus phospholipid transporting atpase ih 0.0036 0.0014 0.0014
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0009 0.0009
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0828 0.0819 0.0819
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.033 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0248 0.0229 0.0345
Echinococcus granulosus ecdysone induced protein 78C 0.0126 0.0106 0.0106
Plasmodium falciparum importin beta, putative 0.0028 0.0006 0.0252
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0009 0.0024
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.006 0.0038 0.0038
Trichomonas vaginalis CAMK family protein kinase 0.0417 0.0401 1
Schistosoma mansoni flap endonuclease-1 0.0025 0.0003 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0054 0.1336
Echinococcus multilocularis mitogen activated protein kinase 11 0.0138 0.0118 0.0118
Schistosoma mansoni phospholipid-transporting atpase 0.0036 0.0014 0.0036
Echinococcus multilocularis expressed protein 0.0026 0.0003 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0019 0.0718
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0156 0.0136 0.0204
Echinococcus multilocularis mitogen activated protein kinase 11 0.0138 0.0118 0.0118
Brugia malayi CHE-14 protein 0.0042 0.002 0.003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0019 0.0029
Schistosoma mansoni chromobox protein 0.0137 0.0116 0.0299
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0157 0.0137 0.3249
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0009 0.0009
Onchocerca volvulus 0.3849 0.3886 0.6379
Loa Loa (eye worm) hypothetical protein 0.0156 0.0136 0.0204
Brugia malayi Calcitonin receptor-like protein seb-1 0.0722 0.071 0.1069
Mycobacterium tuberculosis Probable metal cation transporter ATPase P-type CtpE 0.0031 0.0009 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0126 0.0106 0.0159
Schistosoma mansoni hypothetical protein 0.0082 0.0061 0.0157
Loa Loa (eye worm) hypothetical protein 0.0047 0.0025 0.0038
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0828 0.0819 0.0819
Brugia malayi nuclear receptor NHR-88 0.006 0.0038 0.0057
Echinococcus multilocularis microtubule associated protein 2 0.2094 0.2104 0.2104
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0248 0.0229 0.0345
Loa Loa (eye worm) matrixin family protein 0.6563 0.6643 1
Leishmania major DNA polymerase eta, putative 0.024 0.0221 0.4297
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0013 0.0013
Schistosoma mansoni terminal deoxycytidyl transferase 0.0182 0.0162 0.0418
Loa Loa (eye worm) hypothetical protein 0.0042 0.002 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0000000000020276 0.0000000000030524
Echinococcus granulosus nervana 2 0.0828 0.0819 0.0819
Mycobacterium ulcerans DNA polymerase IV 0.021 0.0191 0.0564
Brugia malayi beta-lactamase family protein 0.0156 0.0136 0.0204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0126 0.0106 0.0159
Brugia malayi Membrane calcium atpase protein 3 0.0162 0.0142 0.0213
Echinococcus multilocularis carbonic anhydrase 0.0248 0.0229 0.0229
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0054 0.0138
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.0159 0.0467
Echinococcus granulosus copper transporting ATPase 1 0.0031 0.0009 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0 0.0009
Brugia malayi Heterochromatin protein 1 0.0137 0.0116 0.0175
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0067 0.0045 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0012 0.0304
Loa Loa (eye worm) hypothetical protein 0.0156 0.0136 0.0204
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0029 0.0564
Echinococcus granulosus acetylcholinesterase 0.0132 0.0112 0.0112
Echinococcus granulosus tar DNA binding protein 0.0133 0.0113 0.0113
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0126 0.0106 0.0272
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0025 0.0633
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.033 0.0313 0.0471
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0092 0.0071 0.1768
Entamoeba histolytica hypothetical protein 0.0023 0 0.0009
Schistosoma mansoni tsg101-related 0.0062 0.004 0.0102
Echinococcus multilocularis nervana 2 0.0828 0.0819 0.0819
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0019 0.0048
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0436 0.042 0.1081
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0133 0.0112 0.0112
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0182 0.0162 0.0162
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0045 0.0115
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0157 0.0137 0.2644
Loa Loa (eye worm) hypothetical protein 0.0076 0.0054 0.0082
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0041 0.0019 0.0019
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.0269 0.6527
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0828 0.0819 0.0819
Plasmodium falciparum thioredoxin reductase 0.0057 0.0035 0.1538
Echinococcus granulosus histone acetyltransferase KAT2B 0.0092 0.0071 0.0071
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0126 0.0106 0.0106
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0092 0.0071 0.3091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0126 0.0106 0.0106
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0046 0.0024 0.0609
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0022 0.0000000000020276 0.000000000088471
Echinococcus granulosus thyroid hormone receptor alpha 0.006 0.0038 0.0038
Echinococcus multilocularis acetylcholinesterase 0.0132 0.0112 0.0112
Brugia malayi ImpB/MucB/SamB family protein 0.024 0.0221 0.0332
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.011 0.0319
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0075 0.0054 0.1035
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.423 0.4273 0.4273
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0048 0.0026 0.0656
Loa Loa (eye worm) hypothetical protein 0.0178 0.0158 0.0237
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA 0.0031 0.0009 0.0016
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.011 0.0277
Brugia malayi isocitrate dehydrogenase 0.005 0.0028 0.0042
Brugia malayi hypothetical protein 0.0049 0.0027 0.0041
Schistosoma mansoni hypothetical protein 0.0022 0.0000000000020276 0.0000000000052178
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0067 0.0046 0.0127
Echinococcus multilocularis musashi 0.0033 0.001 0.001
Leishmania major phospholipid-transporting ATPase 1-like protein 0.0036 0.0014 0.0267
Trichomonas vaginalis cation-transporting ATPase, putative 0.0031 0.0009 0.0229
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.017 0.4239
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Echinococcus granulosus beta LACTamase domain containing family member 0.0156 0.0136 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0004 0.0088
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0006 0.0088
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0528 0.0514 0.1322
Schistosoma mansoni hypothetical protein 0.004 0.0018 0.0047
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.002 0.002
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.005 0.0028 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0269 0.6722
Giardia lamblia Phospholipid-transporting ATPase IIB, putative 0.0036 0.0014 0.0216
Leishmania major P-type H -ATPase, putative 0.009 0.0069 0.1336
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0341 0.0324 0.0833
Leishmania major proton motive ATPase, putative 0.0031 0.0009 0.0172
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0005 0.0097
Loa Loa (eye worm) Smad1 0.0025 0.0002 0.0003
Schistosoma mansoni cpg binding protein 0.0121 0.01 0.0257
Trichomonas vaginalis chromobox protein, putative 0.0137 0.0116 0.2902
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0126 0.0106 0.0159
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0031 0.0009 0.0229
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0035 0.0053
Schistosoma mansoni steroid hormone receptor ad4bp 0.0126 0.0106 0.0272
Echinococcus granulosus expressed protein 0.0026 0.0003 0.0003
Trypanosoma brucei protein kinase, putative 0.0075 0.0054 0.102
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0828 0.0819 0.0819
Loa Loa (eye worm) hypothetical protein 0.0031 0.0009 0.0014
Echinococcus granulosus nuclear receptor nhr 48 0.006 0.0038 0.0038
Schistosoma mansoni nuclear receptor nhr-48 0.006 0.0038 0.0097
Leishmania major hypothetical protein, conserved 0.0156 0.0136 0.2637
Brugia malayi nuclear receptor NHR-67 0.006 0.0038 0.0057
Echinococcus multilocularis geminin 0.0717 0.0705 0.0705
Plasmodium vivax phospholipid-transporting ATPase, putative 0.0036 0.0014 0.0521
Trypanosoma brucei P-type H+-ATPase, putative 0.009 0.0069 0.1321
Mycobacterium ulcerans metal cation transporter ATPase p-type CtpE 0.0031 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.2714 0.2734 0.4116
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0004 0.0088
Schistosoma mansoni phospholipid-transporting atpase 0.0036 0.0014 0.0036
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0054 0.2366
Schistosoma mansoni carbonic anhydrase-related 0.0248 0.0229 0.059
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0059 0.0037 0.0037
Mycobacterium leprae PROBABLE HYDROLASE 0.3306 0.3335 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0022 0.0000000000020276 0.0000000000020276
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0114 0.0093 0.407
Trypanosoma brucei DNA polymerase kappa, putative 0.0133 0.0112 0.2161
Mycobacterium tuberculosis Probable lipase LipD 0.0156 0.0136 0.0345
Schistosoma mansoni smad1 5 8 and 0.0025 0.0002 0.0006
Trypanosoma brucei chrX additional, unordered contigs 0.0057 0.0035 0.0653
Echinococcus granulosus Smad4 0.0025 0.0002 0.0002
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0162 0.0142 0.0364
Echinococcus multilocularis cation transporting atpase worm 0.0031 0.0009 0.0009
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0005 0.0133
Trypanosoma brucei calcium-translocating P-type ATPase 0.0162 0.0142 0.2739
Schistosoma mansoni ferritin light chain 0.0026 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0722 0.071 0.1069
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.0186 0.0279
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0029 0.0564
Brugia malayi Matrixin family protein 0.2714 0.2734 0.4116
Brugia malayi bZIP transcription factor family protein 0.0101 0.008 0.0121
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0005 0.0233
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0126 0.0106 0.0272
Echinococcus multilocularis nervana 2 0.0828 0.0819 0.0819
Echinococcus multilocularis survival motor neuron protein 1 0.0474 0.0458 0.0458
Echinococcus multilocularis nervana 2 0.0828 0.0819 0.0819
Schistosoma mansoni serine/threonine protein kinase 0.0417 0.0401 0.1031
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0162 0.0142 0.0364
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0121 0.01 0.1942
Loa Loa (eye worm) transbilayer Amphipath transporters family member 0.0036 0.0014 0.0021
Schistosoma mansoni hypothetical protein 0.1626 0.1629 0.4191
Loa Loa (eye worm) E1-E2 ATPase 0.009 0.0069 0.0104
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0133 0.0112 0.2798
Schistosoma mansoni nuclear hormone receptor 0.006 0.0038 0.0097
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0104 0.0083 0.024
Trichomonas vaginalis penicillin-binding protein, putative 0.0156 0.0136 0.3388
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0019 0.0039
Brugia malayi Steroid receptor seven-up type 2 0.0126 0.0106 0.0159
Onchocerca volvulus Matrix metalloproteinase homolog 0.602 0.6091 1
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0036 0.0014 0.0351
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0041 0.0041
Loa Loa (eye worm) matrixin family protein 0.602 0.6091 0.917
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0124 0.0315
Echinococcus multilocularis expressed conserved protein 0.0091 0.007 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0035 0.0668
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0157 0.0137 0.3413
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0041 0.0041
Mycobacterium leprae conserved hypothetical protein 0.0156 0.0136 0.0398
Schistosoma mansoni aldehyde dehydrogenase 0.0179 0.0159 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0004 0.0088
Brugia malayi nuclear receptor RXR 0.006 0.0038 0.0057
Brugia malayi hypothetical protein 0.006 0.0038 0.0057
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0828 0.0819 0.0819
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0341 0.0324 0.0487
Mycobacterium ulcerans oxidoreductase 0.0041 0.0019 0.0049
Onchocerca volvulus 0.0828 0.0819 0.1344
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.033 0.0313 0.0313
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.0112 0.0287
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0031 0.0009 0.0401
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0019 0.0364
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0059 0.0037 0.0055
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0019 0.0019
Onchocerca volvulus 0.006 0.0038 0.0062
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0119 0.0098 0.0247
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3578 0.3611 0.9388
Schistosoma mansoni importin beta-1 0.0028 0.0006 0.0015
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0007 0.0007
Brugia malayi hypothetical protein 0.0067 0.0045 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0025 0.0067
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.011 0.0277
Loa Loa (eye worm) phospholipid-transporting ATPase ID 0.0036 0.0014 0.0021
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0025 0.0633
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0031 0.0009 0.0024
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0048 0.0026 0.1154
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0095 0.0074 0.1843
Echinococcus multilocularis neuropeptide receptor A26 0.0573 0.0559 0.0559
Echinococcus multilocularis beta LACTamase domain containing family member 0.0156 0.0136 0.0136
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0126 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.002
Trypanosoma cruzi DNA polymerase eta, putative 0.0114 0.0093 0.181
Echinococcus granulosus dna polymerase eta 0.024 0.0221 0.0221
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.008 0.0059 0.1135
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0156 0.0136 0.0345
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0005 0.0008
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.006 0.0038 0.0057
Echinococcus granulosus FTZ F1 alpha 0.0126 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.008 0.0059 0.0088
Trypanosoma cruzi polo-like protein kinase, putative 0.0417 0.0401 0.7798
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.0159 0.0467
Trypanosoma cruzi DNA repair protein, putative 0.0071 0.005 0.096
Loa Loa (eye worm) hypothetical protein 0.0077 0.0055 0.0083
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0092 0.0071 0.1761
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.002
Echinococcus multilocularis Smad4 0.0025 0.0002 0.0002
Echinococcus granulosus importin subunit beta 1 0.0028 0.0006 0.0006
Schistosoma mansoni apoferritin-2 0.0026 0.0003 0.0008
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0041 0.0019 0.005
Echinococcus multilocularis dna polymerase eta 0.024 0.0221 0.0221
Echinococcus multilocularis cpg binding protein 0.0121 0.01 0.01
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase CtpV 0.0031 0.0009 0.0016
Plasmodium vivax glutathione reductase, putative 0.0057 0.0035 0.1305
Treponema pallidum hypothetical protein 0.0047 0.0025 0.0825
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0029 0.0007 0.0007
Trypanosoma cruzi DNA damage repair protein, putative 0.0057 0.0035 0.0668
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0126 0.0106 0.0159
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.033 0.0313 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0189 0.0169 0.3282
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0019 0.0846
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0271 0.6758
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0002 0.0003
Mycobacterium ulcerans cation transporter p-type ATPase a CtpA 0.0031 0.0009 0.0018
Echinococcus multilocularis lamin 0.0033 0.001 0.001
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0341 0.0324 0.0324
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0528 0.0514 1
Echinococcus granulosus snurportin 1 0.03 0.0282 0.0282
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0075 0.0054 0.2334
Schistosoma mansoni intermediate filament proteins 0.0033 0.001 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0417 0.0401 1
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0000000000020276 0.000000000075057
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0179 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.004 0.0018 0.0047
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.008 0.0059 0.1135
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0828 0.0819 0.2106
Leishmania major carbonic anhydrase-like protein 0.0528 0.0514 1
Onchocerca volvulus 0.0033 0.001 0.0017
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0014 0.0014
Trypanosoma brucei carbonic anhydrase-like protein 0.0528 0.0514 1
Brugia malayi ImpB/MucB/SamB family protein 0.0182 0.0162 0.0244
Brugia malayi hypothetical protein 0.006 0.0038 0.0057
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3809 0.3846 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.0348 0.6767
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0025 0.0067
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0172 0.0152 0.0152
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0025 0.0067
Echinococcus granulosus carbonic anhydrase 0.0248 0.0229 0.0229
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0828 0.0819 0.2106
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0133 0.0112 0.2798
Schistosoma mansoni type V p-type atpase isoform 0.0031 0.0009 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0271 0.6758
Echinococcus granulosus neuropeptide receptor A26 0.0573 0.0559 0.0559
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0313 0.0295 0.076
Schistosoma mansoni ferritin light chain 0.0026 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0057
Toxoplasma gondii hypothetical protein 0.0116 0.0095 0.4166
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.3306 0.3335 0.502
Onchocerca volvulus 0.0828 0.0819 0.1344
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0075 0.0054 0.1035
Giardia lamblia Kinase, CMGC MAPK 0.0075 0.0054 0.1191
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0228 0.0209 0.0209
Schistosoma mansoni carbonic anhydrase-related 0.0248 0.0229 0.059
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0828 0.0819 0.2106
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0036 0.0014 0.0351
Brugia malayi hypothetical protein 0.0619 0.0606 0.0912
Trypanosoma cruzi polo-like protein kinase, putative 0.0417 0.0401 0.7798
Leishmania major DNA damage repair protein, putative 0.0057 0.0035 0.0668
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0005 0.0005
Chlamydia trachomatis recombinase RecA 0.0231 0.0212 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0057
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0037 0.0918
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0162 0.0142 0.0142
Onchocerca volvulus 0.2714 0.2734 0.4488
Echinococcus granulosus inositol monophosphatase 1 0.0121 0.01 0.01
Trypanosoma cruzi DNA repair protein, putative 0.0071 0.005 0.096
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0031 0.0009 0.0172
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0041 0.0019 0.005
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0036 0.0014 0.0351
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0009 0.0014
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0075 0.0054 0.1035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0048 0.0026 0.0656
Trypanosoma brucei DNA polymerase kappa, putative 0.021 0.0191 0.3703
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.011 0.0277
Trypanosoma cruzi DNA polymerase kappa, putative 0.021 0.0191 0.3714
Treponema pallidum recombinase A 0.0231 0.0212 0.7861
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0133 0.0112 0.2798
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0014 0.0352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0269 0.6722
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0036 0.0014 0.0351
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0138 0.0118 0.2285
Mycobacterium ulcerans hypothetical protein 0.0047 0.0025 0.0067
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0377 0.036 0.0542
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0077 0.0199
Brugia malayi steroid hormone receptor 0.0126 0.0106 0.0159
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0014 0.0014
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0019 0.0041
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0013 0.0488
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0025 0.0038
Trypanosoma cruzi DNA polymerase eta, putative 0.024 0.0221 0.4297
Schistosoma mansoni DNA polymerase IV / kappa 0.0057 0.0035 0.0089
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0179 0.0159 0.3088
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0417 0.0401 0.7798
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0126 0.0106 0.0106
Echinococcus multilocularis protein patched 0.0042 0.002 0.002
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0113 0.029
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0162 0.0142 0.0142
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0126 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0031 0.0009 0.0014
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.008 0.0059 0.0088
Mycobacterium tuberculosis Probable lipase LipE 0.0156 0.0136 0.0345
Echinococcus multilocularis ferritin 0.0026 0.0003 0.0003
Mycobacterium ulcerans putative regulatory protein 0.0042 0.002 0.0051
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.9869 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0075 0.0054 0.0054
Trichomonas vaginalis cation-transporting ATPase, putative 0.0036 0.0014 0.0351
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0133 0.0112 0.2176
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0108 0.0087 0.0219
Mycobacterium leprae Probable lipase LipE 0.0156 0.0136 0.0398
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0722 0.071 0.1069
Loa Loa (eye worm) hypothetical protein 0.0157 0.0137 0.0206
Trichomonas vaginalis hypothetical protein 0.0036 0.0014 0.0344
Loa Loa (eye worm) hypothetical protein 0.0126 0.0106 0.0159
Loa Loa (eye worm) hypothetical protein 0.0126 0.0106 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0035 0.0668
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.0016
Echinococcus multilocularis Nuclear hormone receptor HR96 0.006 0.0038 0.0038
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0121 0.01 0.0236
Trypanosoma brucei phospholipid-translocating P-type ATPase (flippase), putative 0.0036 0.0014 0.025
Trichomonas vaginalis penicillin-binding protein, putative 0.0156 0.0136 0.3388
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0126 0.0106 0.0159
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0055
Onchocerca volvulus Bile acid receptor homolog 0.0126 0.0106 0.0173
Echinococcus multilocularis phospholipid transporting ATPase IA 0.0036 0.0014 0.0014
Echinococcus multilocularis smad 0.0025 0.0002 0.0002
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.006 0.0038 0.0062
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0528 0.0514 0.1322
Loa Loa (eye worm) carbonic anhydrase 3 0.0528 0.0514 0.0773
Loa Loa (eye worm) hypothetical protein 0.0041 0.0019 0.0029
Echinococcus granulosus dna polymerase kappa 0.021 0.0191 0.0191
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0157 0.0137 0.3413
Brugia malayi hypothetical protein 0.0076 0.0054 0.0082
Schistosoma mansoni eyes absent homolog 0.0106 0.0085 0.0219
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0157 0.0137 0.3413
Trypanosoma brucei DNA polymerase kappa, putative 0.0133 0.0112 0.2161
Brugia malayi Carboxylesterase family protein 0.0132 0.0112 0.0168
Echinococcus multilocularis cation transporting ATPase 13A1 0.0031 0.0009 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.018 0.4498
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0025 0.0038
Schistosoma mansoni zinc finger protein 0.006 0.0038 0.0097
Echinococcus granulosus Nuclear hormone receptor HR96 0.006 0.0038 0.0038
Onchocerca volvulus 0.0033 0.001 0.0017
Brugia malayi MH2 domain containing protein 0.0025 0.0002 0.0003
Brugia malayi Carboxylesterase family protein 0.0132 0.0112 0.0168
Mycobacterium ulcerans metal cation-transporting p-type ATPase CtpC 0.0031 0.0009 0.0018
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0035 0.0679
Mycobacterium tuberculosis Probable reductase 0.013 0.011 0.0277
Entamoeba histolytica acetyltransferase, GNAT family 0.0084 0.0063 0.1574
Giardia lamblia Histone acetyltransferase GCN5 0.0084 0.0063 0.1427
Brugia malayi photoreceptor-specific nuclear receptor 0.0126 0.0106 0.0159
Echinococcus granulosus Protein patched homolog 1 0.0042 0.002 0.002
Brugia malayi N-terminal motif family protein 0.0178 0.0158 0.0237
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0126 0.0106 0.0106
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.0068 0.0068
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0041 0.0019 0.0049
Brugia malayi nuclear hormone receptor family member nhr-6 0.006 0.0038 0.0057
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0005 0.0133
Trichomonas vaginalis cation-transporting ATPase, putative 0.0036 0.0014 0.0351
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.005 0.0028 0.054
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0048 0.0026 0.0656
Trichomonas vaginalis CAMK family protein kinase 0.0417 0.0401 1
Brugia malayi Isocitrate dehydrogenase 0.005 0.0028 0.0042
Toxoplasma gondii hypothetical protein 0.0059 0.0037 0.1614
Brugia malayi hypothetical protein 0.0025 0.0003 0.0004
Schistosoma mansoni smad1 5 8 and 0.0025 0.0002 0.0006
Echinococcus multilocularis GPCR, family 2 0.0228 0.0209 0.0209
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0118 0.0118
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0133 0.0112 0.2798
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0077 0.0055 0.1382
Brugia malayi RNA binding protein 0.0133 0.0113 0.017
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0045 0.0115
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0035 0.1305
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.3306 0.3335 0.8669
Schistosoma mansoni DNA polymerase eta 0.024 0.0221 0.0568
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0133 0.0112 0.0112
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0156 0.0136 0.0349
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0024 0.0001 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0048 0.0026 0.0656
Plasmodium vivax importin-beta 2, putative 0.0028 0.0006 0.0214
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0048 0.0026 0.0656
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0019 0.0029
Onchocerca volvulus 0.0047 0.0025 0.0042
Brugia malayi MAP kinase sur-1 0.0075 0.0054 0.0081
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0119 0.0098 0.0285
Schistosoma mansoni cation-transporting atpase worm 0.0031 0.0009 0.0024
Brugia malayi Matrixin family protein 0.6563 0.6643 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0126 0.0106 0.0173
Schistosoma mansoni ferritin 0.0026 0.0003 0.0008
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.0113 0.017
Trypanosoma cruzi phospholipid-transporting ATPase 1-like protein, putative 0.0036 0.0014 0.0267
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.0035 0.0653
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0228 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0126 0.0106 0.0159
Loa Loa (eye worm) hypothetical protein 0.0067 0.0045 0.0068
Echinococcus granulosus carbonic anhydrase 0.0248 0.0229 0.0229
Leishmania major DNA polymerase eta, putative 0.0114 0.0093 0.181
Trypanosoma brucei DNA polymerase kappa, putative 0.021 0.0191 0.3703
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0032 0.0809
Trypanosoma brucei DNA polymerase IV, putative 0.021 0.0191 0.3703
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0036 0.0014 0.0351
Loa Loa (eye worm) calcium ATPase 0.0092 0.0071 0.0106
Brugia malayi Flap endonuclease-1 0.0028 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0057
Echinococcus granulosus phospholipid transporting ATPase VA 0.0025 0.0003 0.0003
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0138 0.0118 0.2272
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0828 0.0819 0.0819
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0004 0.0088
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0002 0.0002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.033 0.0313 0.0471
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0029 0.0564
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.0028 0.0524
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0038 0.0038
Giardia lamblia Phospholipid-transporting ATPase IIB, putative 0.0036 0.0014 0.0216
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0042 0.002 0.0044
Trypanosoma cruzi DNA polymerase kappa, putative 0.021 0.0191 0.3714
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.005 0.0028 0.1039
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0077 0.0055 0.0091
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.002 0.003
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0121 0.01 0.2497
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.006 0.0038 0.0097
Echinococcus multilocularis neuropeptide s receptor 0.0573 0.0559 0.0559
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0002 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.0067 0.0045 0.0068
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0828 0.0819 0.2106
Brugia malayi nuclear receptor RXR 0.0067 0.0045 0.0068
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0025 0.0067
Loa Loa (eye worm) hypothetical protein 0.0126 0.0106 0.0159
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.0071 0.0071
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.011 0.0277
Entamoeba histolytica deoxycytidyl transferase, putative 0.0182 0.0162 0.4051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0225 0.0206 0.898
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0166 0.0146 0.0428
Schistosoma mansoni amine oxidase 0.0041 0.0019 0.005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0182 0.0162 0.0414
Schistosoma mansoni nuclear receptor 0.006 0.0038 0.0097
Echinococcus multilocularis Chromobox protein 3 0.0022 0.0000000022589 0.0000000022589
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0426 0.041 0.041
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.005 0.0028 0.1225
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0248 0.0229 0.0345
Echinococcus multilocularis ecdysone induced protein 78C 0.0126 0.0106 0.0106
Brugia malayi CHD4 protein 0.0029 0.0007 0.001
Toxoplasma gondii hypothetical protein 0.0248 0.0229 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0013 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0126 0.0106 0.0159
Brugia malayi tailless protein 0.006 0.0038 0.0057
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0228 0.0209 0.0209
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0037 0.0918
Entamoeba histolytica phospholipid-transporting ATPase IA, putative 0.0036 0.0014 0.0351
Plasmodium vivax hypothetical protein, conserved 0.0042 0.002 0.0748
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0036 0.0014 0.0351
Brugia malayi Matrixin family protein 0.2714 0.2734 0.4116
Trypanosoma brucei unspecified product 0.0126 0.0105 0.2022
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0057
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.012 0.035
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0014
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0074 0.0052 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.021 0.0191 0.3703
Toxoplasma gondii thioredoxin reductase 0.0057 0.0035 0.1538
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0063 0.1212
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0011 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0019 0.0718
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0075 0.0054 0.0081
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.0074 0.0074
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0189 0.0169 0.3293
Mycobacterium ulcerans esterase/lipase LipP 0.0156 0.0136 0.0398
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0011 0.0021
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Brugia malayi beta-lactamase 0.0156 0.0136 0.0204
Mycobacterium tuberculosis Conserved protein 0.0156 0.0136 0.0345
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.002 0.0489
Leishmania major P-type H -ATPase, putative 0.009 0.0069 0.1336
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.0348 0.6767
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0172 0.0152 0.3793
Echinococcus multilocularis thyroid hormone receptor alpha 0.0126 0.0106 0.0106
Schistosoma mansoni transcription factor LCR-F1 0.033 0.0312 0.0804
Onchocerca volvulus 0.0156 0.0136 0.0223
Echinococcus granulosus intermediate filament protein 0.0033 0.001 0.001
Brugia malayi hypothetical protein 0.0067 0.0045 0.0068
Brugia malayi Thioredoxin reductase 0.0057 0.0035 0.0053
Schistosoma mansoni transient receptor potential channel 0.0095 0.0074 0.0191
Onchocerca volvulus 0.006 0.0038 0.0062
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0019 0.0019
Schistosoma mansoni nuclear hormone receptor 0.006 0.0038 0.0097
Trichomonas vaginalis CAMK family protein kinase 0.0417 0.0401 1
Schistosoma mansoni jun-related protein 0.0082 0.0061 0.0157
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0172 0.0152 0.3793
Trypanosoma brucei P-type H+-ATPase, putative 0.009 0.0069 0.1321
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0059 0.0037 0.0918
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0474 0.0458 0.069
Trichomonas vaginalis cation-transporting ATPase, putative 0.0157 0.0137 0.3413
Schistosoma mansoni inositol monophosphatase 0.0121 0.01 0.0257
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0157 0.0137 0.3413
Trichomonas vaginalis cation-transporting ATPase, putative 0.0157 0.0137 0.3413
Echinococcus multilocularis lamin dm0 0.0033 0.001 0.001
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0162 0.0142 0.0364
Mycobacterium ulcerans hypothetical protein 0.0057 0.0035 0.0097
Loa Loa (eye worm) hypothetical protein 0.0041 0.0019 0.0029
Echinococcus multilocularis Chromo domain 0.0022 0.0000000000020276 0.0000000000020276
Loa Loa (eye worm) glutathione reductase 0.0057 0.0035 0.0053
Schistosoma mansoni hypothetical protein 0.0248 0.0229 0.059
Mycobacterium ulcerans hypothetical protein 0.0057 0.0035 0.0095
Mycobacterium ulcerans recombinase A 0.0231 0.0212 0.0628
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0269 0.6722
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0019 0.034
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0012 0.0012
Schistosoma mansoni coup transcription factor 0.0126 0.0106 0.0272
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0172 0.0152 0.6629
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0126 0.0106 0.0272
Trypanosoma cruzi hypothetical protein, conserved 0.0156 0.0136 0.2637
Entamoeba histolytica serine/threonine protein kinase, putative 0.0417 0.0401 1
Schistosoma mansoni microtubule-associated protein tau 0.2094 0.2104 0.5414
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0059 0.0037 0.0037
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0007 0.0007
Trichomonas vaginalis chromobox protein, putative 0.0137 0.0116 0.2902
Trichomonas vaginalis cation-transporting ATPase, putative 0.009 0.0069 0.1721
Entamoeba histolytica hypothetical protein 0.033 0.0312 0.78
Entamoeba histolytica hypothetical protein 0.033 0.0312 0.78
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.008 0.0059 0.2558
Entamoeba histolytica hypothetical protein 0.033 0.0312 0.78
Brugia malayi glutathione reductase 0.0057 0.0035 0.0053
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.0269 0.6722
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0009
Echinococcus granulosus mitogen activated protein kinase 14 0.0138 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0228 0.0209 0.0538
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0162 0.0142 0.2739
Onchocerca volvulus 0.0156 0.0136 0.0223
Mycobacterium tuberculosis Conserved protein 0.0156 0.0136 0.0345
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.005 0.0028 0.0065
Trichomonas vaginalis D-aminoacylase, putative 0.0156 0.0136 0.3388
Schistosoma mansoni RAR-like nuclear receptor 0.0126 0.0106 0.0272
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0025 0.0003 0.0122
Toxoplasma gondii histone lysine-specific demethylase 0.0041 0.0019 0.0846
Onchocerca volvulus Glucosylceramidase homolog 0.019 0.017 0.0279
Schistosoma mansoni hypothetical protein 0.004 0.0018 0.0047
Schistosoma mansoni Smad4 0.0025 0.0002 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0055 0.1377
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0057
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0019 0.0364
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0126 0.0106 0.0159
Giardia lamblia Copper-transporting P-type ATPase 0.0031 0.0009 0.0095
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0019 0.0476
Trichomonas vaginalis ferritin, putative 0.0026 0.0003 0.0079
Schistosoma mansoni lamin 0.0033 0.001 0.0027
Loa Loa (eye worm) hypothetical protein 0.0828 0.0819 0.1232
Echinococcus granulosus expressed conserved protein 0.0091 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0041 0.0019 0.0029
Trypanosoma brucei hypothetical protein, conserved 0.0156 0.0136 0.2624
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0022 0.0000000000020276 0.000000000088471
Leishmania major DNA polymerase kappa, putative 0.0189 0.0169 0.3293
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0133 0.0112 0.2176
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0006 0.0252
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.017 0.4239
Brugia malayi Nuclear hormone receptor E75 0.006 0.0038 0.0057
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0233 0.0214 0.0633
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0417 0.0401 0.0603
Mycobacterium leprae Conserved hypothetical protein 0.1358 0.1356 0.4061
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0036 0.0014 0.0351
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0103 0.0082 0.0123
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0076 0.1896
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0005 0.008
Echinococcus multilocularis inositol monophosphatase 1 0.0121 0.01 0.01
Trypanosoma cruzi DNA polymerase kappa, putative 0.021 0.0191 0.3714
Loa Loa (eye worm) hypothetical protein 0.0828 0.0819 0.1232
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0156 0.0136 0.0345
Brugia malayi Matrixin family protein 0.2714 0.2734 0.4116
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0157 0.0137 0.2657
Plasmodium vivax hypothetical protein, conserved 0.0156 0.0136 0.5023
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0271 0.6758
Brugia malayi SET domain containing protein 0.0026 0.0004 0.0005
Leishmania major hypothetical protein, conserved 0.0024 0.0001 0.0017
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0288 0.027 1
Plasmodium falciparum copper-transporting ATPase 0.0031 0.0009 0.0401
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0126 0.0106 0.0106
Echinococcus multilocularis isocitrate dehydrogenase 0.005 0.0028 0.0028
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0038 0.0038
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0076 0.0076
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0157 0.0137 0.3413
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0095 0.2384
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0019 0.0019
Brugia malayi hypothetical protein 0.0041 0.0019 0.0029
Brugia malayi CXXC zinc finger family protein 0.0114 0.0093 0.014
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0075 0.0054 0.1035
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0101 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0126 0.0106 0.0159
Trypanosoma brucei phospholipid-transporting ATPase 1-like protein, putative 0.0036 0.0014 0.025
Brugia malayi Matrixin family protein 0.2714 0.2734 0.4116
Mycobacterium tuberculosis Probable hydrolase 0.0156 0.0136 0.0345
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.0269 1
Leishmania major phospholipid-translocating P-type ATPase (flippase), putative 0.0036 0.0014 0.0267
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0000000000020276 0.000000000050622
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0228 0.0209 0.0315
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0035 0.0035
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0041 0.0019 0.0049
Loa Loa (eye worm) hypothetical protein 0.0085 0.0063 0.0095
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0054 0.1049
Brugia malayi beta-lactamase family protein 0.0156 0.0136 0.0204
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0133 0.0112 0.0288
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0041 0.0019 0.0718
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0133 0.0112 0.2163
Plasmodium falciparum DNA repair protein REV1, putative 0.0057 0.0035 0.1513
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0057
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0025 0.0003 0.0003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.011 0.0277
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0067 0.0045 0.0068
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0189 0.0169 0.0432
Echinococcus multilocularis 0.0041 0.0019 0.0019
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0029 0.0548
Toxoplasma gondii hypothetical protein 0.0042 0.002 0.0881
Schistosoma mansoni transient receptor potential channel 0.0063 0.0041 0.0107
Echinococcus multilocularis carboxylesterase 5A 0.0132 0.0112 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0095 0.2384
Trypanosoma brucei DNA polymerase kappa, putative 0.021 0.0191 0.3703
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0121 0.01 0.2497
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0269 0.6722
Brugia malayi Nuclear hormone receptor E75 0.006 0.0038 0.0057
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0074 0.0052 0.0052
Schistosoma mansoni ap endonuclease 0.0041 0.0019 0.0049
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0057
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0058
Trypanosoma brucei DNA polymerase IV, putative 0.0203 0.0184 0.3564
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0126 0.0106 0.0159
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0133 0.0112 0.2798
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.002 0.002
Leishmania major calcium-transporting ATPase, putative 0.0162 0.0142 0.2752
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.001 0.0016
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.009 0.0069 0.1339
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0095 0.2384
Loa Loa (eye worm) steroid hormone receptor 0.0126 0.0106 0.0159
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0248 0.0229 0.0345
Mycobacterium ulcerans putative regulatory protein 0.0042 0.002 0.0051
Loa Loa (eye worm) hypothetical protein 0.0436 0.042 0.0632
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0133 0.0112 0.2798
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0121 0.01 0.1942
Loa Loa (eye worm) DR-78 0.006 0.0038 0.0057
Echinococcus granulosus carbonic anhydrase 0.0248 0.0229 0.0229
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0126 0.0106 0.0159
Brugia malayi nuclear receptor NHR-88 0.0126 0.0106 0.0159
Schistosoma mansoni type V p-type atpase isoform 0.0036 0.0014 0.0036
Leishmania major trypanothione reductase 0.0057 0.0035 0.0679
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0031 0.0009 0.0229
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0057 0.0035 0.1513
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0269 0.6722
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0156 0.0136 0.0345
Loa Loa (eye worm) acetylcholinesterase 1 0.0132 0.0112 0.0168
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0377 0.036 0.0542
Trypanosoma brucei cation-transporting ATPase, putative 0.0031 0.0009 0.0155
Plasmodium vivax P-type ATPase4, putative 0.0172 0.0152 0.5623
Brugia malayi P38 map kinase family protein 2 0.0138 0.0118 0.0177
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.002
Echinococcus multilocularis cation transporting ATPase 13A3 0.0031 0.0009 0.0009
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0248 0.0229 0.0345
Echinococcus multilocularis phospholipid transporting ATPase IF 0.0036 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0493 0.0478 0.072
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0092 0.0071 0.0106
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0038 0.0038
Brugia malayi jmjC domain containing protein 0.0067 0.0045 0.0067
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0172 0.0152 0.6629
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0013 0.0575
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0007 0.0007
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0019 0.0476
Onchocerca volvulus 0.008 0.0058 0.0095
Loa Loa (eye worm) hypothetical protein 0.0331 0.0313 0.0471
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Brugia malayi hypothetical protein 0.008 0.0058 0.0088
Trichomonas vaginalis DNA polymerase eta, putative 0.021 0.0191 0.4767
Onchocerca volvulus 0.0126 0.0106 0.0173
Echinococcus granulosus cation transporting atpase worm 0.0031 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0041 0.0019 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.021 0.0191 0.3703
Trypanosoma brucei isocitrate dehydrogenase, putative 0.005 0.0028 0.0524
Echinococcus multilocularis dnaJ subfamily B 0.1626 0.1629 0.1629
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0057
Echinococcus granulosus carbonic anhydrase II 0.0528 0.0514 0.0514
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0126 0.0106 0.0159
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0133 0.0112 0.2163
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0025 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0126 0.0106 0.0159
Schistosoma mansoni hypothetical protein 0.0493 0.0478 0.1231
Loa Loa (eye worm) hypothetical protein 0.0099 0.0077 0.0117
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0098 0.0077 0.0192
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0031 0.0009 0.0229
Mycobacterium ulcerans lipase LipD 0.0156 0.0136 0.0398
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.0113 0.017
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.0348 0.6767
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0025 0.0058
Loa Loa (eye worm) hypothetical protein 0.0095 0.0074 0.0112
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0006 0.0088
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0031 0.0009 0.0009
Trypanosoma cruzi P-type H+-ATPase, putative 0.009 0.0069 0.1336
Toxoplasma gondii hypothetical protein 0.0042 0.002 0.0881
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0057
Brugia malayi E1-E2 ATPase family protein 0.0031 0.0009 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.0361 0.0344 0.0517
Onchocerca volvulus Protein ultraspiracle homolog 0.0126 0.0106 0.0173
Chlamydia trachomatis protoporphyrinogen oxidase 0.0041 0.0019 0.0502
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0098 0.0077 0.0221
Echinococcus multilocularis nervana 2 0.0828 0.0819 0.0819
Brugia malayi serine/threonine-protein kinase plk-2 0.0417 0.0401 0.0603
Echinococcus granulosus histone acetyltransferase KAT2B 0.0305 0.0287 0.0287
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.018 0.4498
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0126 0.0106 0.0106
Echinococcus granulosus carboxylesterase 5A 0.0132 0.0112 0.0112
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0528 0.0514 0.0773
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0156 0.0136 0.0349
Leishmania major P-type ATPase, putative 0.0162 0.0142 0.2752
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0103 0.0082 0.0123
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.005 0.0028 0.0706
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0126 0.0106 0.0106
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0031 0.0009 0.0155
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0057
Schistosoma mansoni hypothetical protein 0.0097 0.0075 0.0194
Echinococcus multilocularis jun protein 0.0101 0.008 0.008
Schistosoma mansoni patched 1 0.0042 0.002 0.005
Plasmodium falciparum carbonic anhydrase 0.0248 0.0229 1
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0031 0.0009 0.0014
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.0269 0.6722
Echinococcus granulosus geminin 0.0717 0.0705 0.0705
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0041 0.0019 0.0846
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0138 0.0118 0.0177
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0012 0.0012
Schistosoma mansoni carbonic anhydrase-related 0.0248 0.0229 0.059
Entamoeba histolytica hypothetical protein 0.0022 0.0000000000020276 0.000000000050622
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0157 0.0137 0.2657
Entamoeba histolytica hypothetical protein 0.033 0.0312 0.78
Brugia malayi MH1 domain containing protein 0.0025 0.0002 0.0003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0000000000020276 0.000000000050622
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0031 0.0009 0.0009
Echinococcus granulosus phospholipid transporting ATPase IA 0.0036 0.0014 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0113 0.029
Plasmodium vivax calcium-transporting ATPase, putative 0.0172 0.0152 0.5623
Loa Loa (eye worm) hypothetical protein 0.0126 0.0106 0.0159
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0243 0.0224 0.0577
Brugia malayi ecdysone receptor 0.006 0.0038 0.0057
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0005 0.0198
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0067 0.0045 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0009 0.0024
Leishmania major hypothetical protein, conserved 0.0076 0.0054 0.1049
Mycobacterium ulcerans cation transporter p-type ATPase D CtpD 0.0031 0.0009 0.0018
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0092 0.0071 0.3091
Mycobacterium ulcerans beta-lactamase 0.0156 0.0136 0.0398
Mycobacterium ulcerans dehydrogenase 0.0041 0.0019 0.0049
Trichomonas vaginalis CAMK family protein kinase 0.0213 0.0193 0.4827
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0019 0.037
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.2224 0.2236 0.5753
Brugia malayi RNA, U transporter 1 0.008 0.0058 0.0088
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0075 0.0054 0.102
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0157 0.0137 0.2644
Brugia malayi hypothetical protein 0.033 0.0312 0.047
Echinococcus multilocularis FTZ F1 alpha 0.0126 0.0106 0.0106
Schistosoma mansoni cpg binding protein 0.0121 0.01 0.0257
Echinococcus multilocularis tar DNA binding protein 0.0133 0.0113 0.0113
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0133 0.0112 0.2798
Trypanosoma brucei trypanothione reductase 0.0057 0.0035 0.0664
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0121 0.01 0.1942
Trypanosoma brucei unspecified product 0.0203 0.0184 0.3564
Echinococcus granulosus cation transporting ATPase 13A3 0.0031 0.0009 0.0009
Brugia malayi Pre-SET motif family protein 0.0205 0.0186 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0112 0.2798
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Loa Loa (eye worm) carboxylesterase 0.0132 0.0112 0.0168
Onchocerca volvulus 0.0097 0.0075 0.0124
Schistosoma mansoni hypothetical protein 0.0034 0.0012 0.003
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.0068 0.0068
Brugia malayi hypothetical protein 0.0074 0.0052 0.0079
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0019 0.0019
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0182 0.0162 0.0244
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0057
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0126 0.0106 0.0272
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0000000000020276 0.000000000050622
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0009 0.0024
Echinococcus granulosus mitogen activated protein kinase 0.0075 0.0054 0.0054
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.001 0.0016
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0002 0.0006
Brugia malayi amine oxidase, flavin-containing family protein 0.0041 0.0019 0.0029
Trypanosoma brucei DNA damage repair protein, putative 0.0057 0.0035 0.0653
Loa Loa (eye worm) hypothetical protein 0.0126 0.0106 0.0159
Brugia malayi MH2 domain containing protein 0.0025 0.0002 0.0003
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.012 0.0304
Onchocerca volvulus 0.0421 0.0405 0.0664
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0000000000020276 0.000000000050622
Schistosoma mansoni hypothetical protein 0.03 0.0282 0.0725
Loa Loa (eye worm) hypothetical protein 0.2714 0.2734 0.4116
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0157 0.0137 0.0137
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0162 0.0142 0.0364
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.017 0.4239
Schistosoma mansoni amine oxidase 0.0041 0.0019 0.005
Toxoplasma gondii P-type ATPase4, putative 0.0172 0.0152 0.6629
Loa Loa (eye worm) hypothetical protein 0.0156 0.0136 0.0204
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0054 0.1049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0126 0.0106 0.0159
Onchocerca volvulus 0.0114 0.0093 0.0153
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0156 0.0136 0.0398
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.006 0.0038 0.0062
Schistosoma mansoni jumonji domain containing protein 0.006 0.0038 0.0098
Brugia malayi phospholipid-translocating P-type ATPase, flippase family protein 0.0036 0.0014 0.0021
Schistosoma mansoni retinoic acid receptor RXR 0.0246 0.0227 0.0583
Plasmodium falciparum GAF domain-related protein, putative 0.0042 0.002 0.0881
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0133 0.0112 0.2176
Echinococcus multilocularis protein dispatched 1 0.0048 0.0026 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0025 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0011 0.0021
Loa Loa (eye worm) intermediate filament protein 0.0033 0.001 0.0016
Onchocerca volvulus Serine\/threonine kinase homolog 0.0417 0.0401 0.0658
Brugia malayi intermediate filament protein 0.0033 0.001 0.0016
Loa Loa (eye worm) RNA binding protein 0.0133 0.0113 0.017
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0133 0.0112 0.2798
Brugia malayi acetyltransferase, GNAT family protein 0.0313 0.0295 0.0445
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0162 0.0142 0.3535
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0103 0.0082 0.1587
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0048 0.0026 0.0656
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.033 0.0312 0.0312
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0019 0.0364
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0019 0.0348
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0042 0.002 0.0044
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0124 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0126 0.0106 0.0159
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0002 0.0002
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0352 0.0335 0.8361
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Echinococcus granulosus flap endonuclease 1 0.0028 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0063 0.1212
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0056
Schistosoma mansoni survival motor neuron protein 0.0097 0.0075 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0055 0.1377
Entamoeba histolytica phospholipid-transporting ATPase Neo1, putative 0.0036 0.0014 0.0351
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.006 0.0038 0.0038
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.0045 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0133 0.0112 0.2161
Echinococcus granulosus chromobox protein 1 0.0137 0.0116 0.0116
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0112 0.2798
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0002 0.0003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0014 0.0352
Onchocerca volvulus Matrilysin homolog 0.602 0.6091 1
Schistosoma mansoni kinase 0.0218 0.0199 0.0511
Loa Loa (eye worm) nuclear receptor nhr-7B 0.006 0.0038 0.0057
Leishmania major calcium-translocating P-type ATPase 0.0157 0.0137 0.2657
Echinococcus granulosus Chromobox protein 3 0.0022 0.0000000022589 0.0000000022589
Mycobacterium tuberculosis Probable esterase LipL 0.0156 0.0136 0.0345
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0426 0.041 0.1054
Trypanosoma brucei DNA polymerase IV, putative 0.021 0.0191 0.3703
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0121 0.01 0.1928
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0019 0.0832
Schistosoma mansoni smad 0.0025 0.0002 0.0006
Loa Loa (eye worm) acetyltransferase 0.0313 0.0295 0.0445
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0548 0.0533 0.138
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.009 0.0069 0.1725
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0019 0.037
Loa Loa (eye worm) hypothetical protein 0.0047 0.0025 0.0038
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.0074 0.0191
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0048 0.0026 0.0656
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0417 0.0401 0.0401
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0179 0.0159 0.0405
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0121 0.01 0.4365
Loa Loa (eye worm) hypothetical protein 0.0132 0.0112 0.0168
Toxoplasma gondii GAF domain-containing protein 0.0042 0.002 0.0881
Loa Loa (eye worm) hypothetical protein 0.024 0.0221 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0004 0.0088
Treponema pallidum cation-transporting ATPase, P-type 0.0031 0.0009 0.0225
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0025 0.0067
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.0061 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0271 0.6758
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0025 0.0633
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0101 0.008 0.008
Mycobacterium ulcerans hypothetical protein 0.0156 0.0136 0.0398
Brugia malayi Protein kinase domain containing protein 0.0031 0.0009 0.0014
Leishmania major DNA polymerase kappa, putative 0.0057 0.0035 0.0668
Giardia lamblia Kinase, PLK 0.0417 0.0401 0.9775
Loa Loa (eye worm) hypothetical protein 0.0228 0.0209 0.0315
Giardia lamblia DINP protein human, muc B family 0.0189 0.0169 0.4057
Echinococcus multilocularis calcium transporting atpase 0.0162 0.0142 0.0142
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0013 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0269 0.6722
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.002
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0000000000020276 0.000000000050622
Schistosoma mansoni ap endonuclease 0.0041 0.0019 0.0049
Trypanosoma cruzi P-type H+-ATPase, putative 0.008 0.0059 0.1135
Brugia malayi nuclear hormone receptor family member odr-7 0.006 0.0038 0.0057
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.2714 0.2734 0.7035
Plasmodium vivax copper-transporting ATPase, putative 0.0031 0.0009 0.034
Onchocerca volvulus 0.0619 0.0606 0.0995
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0038 0.0038
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0162 0.0142 0.2752
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0589 0.0576 0.1718
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0075 0.0054 0.1035
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0166 0.0146 0.0428
Trypanosoma cruzi DNA polymerase kappa, putative 0.021 0.0191 0.3714
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0426 0.041 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0997 0.0989 0.2566
Mycobacterium tuberculosis Probable cation transporter P-type ATPase D CtpD 0.0031 0.0009 0.0016
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0157 0.0137 0.3413
Trichomonas vaginalis CAMK family protein kinase 0.0417 0.0401 1
Brugia malayi Nuclear hormone receptor-like 1 0.0126 0.0106 0.0159
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0076 0.0114
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.017 0.4239
Onchocerca volvulus 0.0233 0.0214 0.0352
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0172 0.044
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0019 0.0597
Echinococcus multilocularis mitogen activated protein kinase 0.0075 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0057
Schistosoma mansoni thyroid hormone receptor 0.0126 0.0106 0.0272
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0118 0.0118
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0019 0.0476
Echinococcus multilocularis carbonic anhydrase II 0.0528 0.0514 0.0514
Echinococcus granulosus Nuclear hormone receptor HR96 0.006 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.004 0.0018 0.0047
Toxoplasma gondii exonuclease III APE 0.0041 0.0019 0.0832
Brugia malayi Hemopexin family protein 0.3849 0.3886 0.585
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0528 0.0514 0.0773
Onchocerca volvulus 0.0022 0.0000000022589 0.0000000037084
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0182 0.0162 0.0162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.0313 0.0805
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0048 0.0026 0.0656
Loa Loa (eye worm) hypothetical protein 0.0097 0.0076 0.0114
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.002
Schistosoma mansoni copper ABC transporter ATPase 0.0031 0.0009 0.0024
Brugia malayi Nuclear hormone receptor-like 1 0.0067 0.0045 0.0068
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0022 0.0000000000020276 0.0000000000052178
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0289 0.0271 0.0408
Loa Loa (eye worm) TAR-binding protein 0.0133 0.0113 0.017
Trypanosoma cruzi cation-transporting ATPase, putative 0.0031 0.0009 0.0172
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0031 0.0009 0.0229
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0036 0.0014 0.0351
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0006 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.033 0.0313 0.0313
Echinococcus multilocularis mitogen activated protein kinase 14 0.0138 0.0118 0.0118
Loa Loa (eye worm) inositol-1 0.0121 0.01 0.0151
Schistosoma mansoni aldehyde dehydrogenase 0.0179 0.0159 0.0409
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0005 0.0097
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.4061 0.4101 1
Loa Loa (eye worm) hypothetical protein 0.0248 0.0229 0.0345
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0067 0.0045 0.0116
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0025 0.0067
Toxoplasma gondii P-type ATPase PMA1 0.009 0.0069 0.3008
Echinococcus granulosus Chromo domain 0.0022 0.0000000000020276 0.0000000000020276
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.0031 0.0009 0.0095
Mycobacterium tuberculosis Possible oxidoreductase 0.0041 0.0019 0.0042
Brugia malayi polk-prov protein 0.0085 0.0063 0.0095
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0035 0.0035
Plasmodium vivax DNA repair protein REV1, putative 0.0057 0.0035 0.1284
Loa Loa (eye worm) nuclear hormone receptor 0.006 0.0038 0.0057
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0248 0.0229 0.0345
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0029 0.0007 0.0017
Schistosoma mansoni ATPase 0.0157 0.0137 0.0352
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0341 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0047 0.0025 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0004 0.0088
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0157 0.0137 0.5965
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0061 0.1525
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0071 0.005 0.0944
Brugia malayi Associated with TFs and helicases family protein 0.0022 0.0000000000020276 0.0000000000030524
Mycobacterium ulcerans DNA polymerase IV 0.021 0.0191 0.0564
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0038 0.0038
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0067 0.0045 0.087
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.0028 0.0028
Echinococcus multilocularis phospholipid transporting atpase ih phospholipid transporting atpase if 0.0036 0.0014 0.0014
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0031 0.0009 0.0229
Loa Loa (eye worm) latrophilin receptor protein 2 0.0228 0.0209 0.0315
Loa Loa (eye worm) hypothetical protein 0.2714 0.2734 0.4116
Echinococcus granulosus nervana 2 0.0828 0.0819 0.0819
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0035 0.0083
Schistosoma mansoni nuclear receptor 0.006 0.0038 0.0097
Echinococcus multilocularis copper transporting ATPase 1 0.0031 0.0009 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0126 0.0106 0.0159
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0025 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0126 0.0106 0.0159
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0589 0.0576 0.1718
Mycobacterium ulcerans cation-transporter p-type ATPase B CtpB 0.0031 0.0009 0.0018
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0289 0.0271 0.0408
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0067 0.0046 0.011
Plasmodium vivax cation transporting ATPase, putative 0.0031 0.0009 0.034
Trypanosoma brucei DNA damage repair protein, putative 0.0057 0.0035 0.0653
Loa Loa (eye worm) hypothetical protein 0.0067 0.0045 0.0068
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0133 0.0112 0.2798
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.0074 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0011 0.0021
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0157 0.0137 0.2657
Trichomonas vaginalis cation-transporting ATPase, putative 0.0157 0.0137 0.3413
Schistosoma mansoni tsg101-related 0.005 0.0028 0.0073
Echinococcus granulosus microtubule associated protein 2 0.2094 0.2104 0.2104
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0153 0.2965
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0828 0.0819 0.0819
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0248 0.0229 0.0345
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0113 0.029
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0113 0.029
Trichomonas vaginalis CAMK family protein kinase 0.0417 0.0401 1
Leishmania major UDP-galactopyranose mutase 0.0041 0.0019 0.037
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0054 0.1336
Trypanosoma brucei polo-like protein kinase 0.0417 0.0401 0.7794
Echinococcus multilocularis dna polymerase kappa 0.021 0.0191 0.0191
Trypanosoma cruzi P-type H+-ATPase, putative 0.009 0.0069 0.1336
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0014 0.0021
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0162 0.0142 0.0364
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0172 0.0152 0.0152
Schistosoma mansoni thyroid hormone receptor 0.0126 0.0106 0.0272
Onchocerca volvulus 0.006 0.0038 0.0063
Loa Loa (eye worm) hypothetical protein 0.0041 0.0019 0.0029
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0067 0.0045 0.0045
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0002 0.0002
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0059 0.0037 0.0055
Schistosoma mansoni ATPase 0.0157 0.0137 0.0352
Echinococcus multilocularis carbonic anhydrase 0.0248 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0067 0.0045 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0054 0.0032 0.0082
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0248 0.0229 0.0345
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0126 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0106 0.0085 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0126 0.0106 0.0159
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0057
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0133 0.0112 0.2798
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0166 0.0146 0.0371
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0162 0.0142 0.0142
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.017 0.4239
Onchocerca volvulus 0.0041 0.0019 0.0032
Leishmania major aminophospholipid translocase, putative 0.0036 0.0014 0.0267
Brugia malayi nuclear hormone receptor 0.0126 0.0106 0.0159
Schistosoma mansoni ferritin 0.0026 0.0003 0.0008
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0436 0.042 0.0632
Echinococcus granulosus nervana 2 0.0828 0.0819 0.0819
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.3306 0.3335 0.502
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.009 0.0069 0.1725
Trypanosoma brucei DNA polymerase kappa, putative 0.021 0.0191 0.3703
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0036 0.0014 0.0351
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0421 0.0405 0.1205
Mycobacterium ulcerans hydrolase 0.3306 0.3335 1
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0022 0.0000000000020276 0.0000000000020276
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0162 0.0142 0.6178
Echinococcus multilocularis carbonic anhydrase 0.0248 0.0229 0.0229
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0271 0.6758
Trichomonas vaginalis D-aminoacylase, putative 0.0156 0.0136 0.3388
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.017 0.4239
Echinococcus granulosus jun protein 0.0101 0.008 0.008
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0022 0.0000000000020276 0.0000000000030524
Loa Loa (eye worm) CXXC zinc finger family protein 0.0114 0.0093 0.014
Brugia malayi hypothetical protein 0.0106 0.0085 0.0128
Loa Loa (eye worm) hypothetical protein 0.0067 0.0045 0.0068
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0162 0.0142 0.0142
Echinococcus granulosus nervana 2 0.0828 0.0819 0.0819
Loa Loa (eye worm) hypothetical protein 0.0619 0.0606 0.0912
Trichomonas vaginalis esterase, putative 0.0156 0.0136 0.3388
Echinococcus granulosus smad 0.0025 0.0002 0.0002
Mycobacterium leprae Probable metal cation-transporting P-type ATPase C CtpC 0.0031 0.0009 0.0018
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.021 0.0191 0.4767
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0031 0.0009 0.0014

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 31.6227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (ADMET) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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