Detailed information for compound 1790737

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 442.594 | Formula: C23H26N2O3S2
  • H donors: 2 H acceptors: 3 LogP: 3.31 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSCCC(=O)Nc1ccc2c(c1)C(=O)c1c2ccc(c1)NC(=O)CCSCC
  • InChi: 1S/C23H26N2O3S2/c1-3-29-11-9-21(26)24-15-5-7-17-18-8-6-16(25-22(27)10-12-30-4-2)14-20(18)23(28)19(17)13-15/h5-8,13-14H,3-4,9-12H2,1-2H3,(H,24,26)(H,25,27)
  • InChiKey: NMVUNGQGKUQEMO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0236 0.0911
Echinococcus granulosus jumonji domain containing 1A 0.0084 0.0955 0.1065
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0156 0.0593
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0236 0.0911
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0374 0.0374
Brugia malayi jmjC domain containing protein 0.0318 0.4631 0.4631
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0156 0.0593
Leishmania major hypothetical protein, conserved 0.0028 0.0066 0.0165
Echinococcus granulosus caspase 3 0.0302 0.4374 0.4879
Schistosoma mansoni z-protein (S1r protein) 0.0066 0.0662 0.0662
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0066
Plasmodium falciparum metacaspase-like protein 0.0184 0.2515 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0184 0.2515 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0184 0.2515 1
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0028 0.0066 0.0234
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.2068 0.2306
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0066 0.0074
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0156 0.0593
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0169 0.0646
Leishmania major hypothetical protein, conserved 0.0028 0.0066 0.0165
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0156 0.0593
Mycobacterium tuberculosis Probable dehydrogenase 0.0221 0.3109 0.8523
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0463 0.1817
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0463 0.1817
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Schistosoma mansoni cpg binding protein 0.003 0.0099 0.0099
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0533 0.2098
Echinococcus multilocularis retinol dehydrogenase 13 0.0028 0.0066 0.0074
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0007 0.0008
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0156 0.0593
Echinococcus multilocularis phd:f box containing protein 0.0084 0.0955 0.1065
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0156 0.0593
Echinococcus granulosus JmjC domain containing protein 4 0.0084 0.0955 0.1065
Plasmodium vivax vivapain-2 0.0034 0.0169 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0662 0.261
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0066 0.0165
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Onchocerca volvulus 0.0034 0.0169 0.0312
Onchocerca volvulus 0.0028 0.0074 0.0128
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0156 0.0593
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0066
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0028 0.0066 0.0074
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0169 0.0646
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0169 0.0169
Mycobacterium ulcerans oxidoreductase 0.0028 0.0066 0.0165
Leishmania major cathepsin L-like protease 0.0034 0.0169 0.0456
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0568 0.0634
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0028 0.0066 0.0234
Echinococcus granulosus axis inhibition protein axin 0.0066 0.0662 0.0738
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0687 0.0687
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0709 0.0791
Onchocerca volvulus 0.0028 0.0066 0.0113
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.049 0.0547
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0066
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0541 0.0604
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Brugia malayi Cathepsin L-like precursor 0.0034 0.0169 0.0169
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0463 0.1817
Brugia malayi CXXC zinc finger family protein 0.0028 0.0074 0.0074
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0485 0.7262 0.81
Mycobacterium ulcerans beta-lactamase 0.004 0.0255 0.0696
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0169 0.0312
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Trypanosoma brucei Aminopeptidase M1, putative 0.0069 0.0709 0.2798
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.3637 1
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0066 0.0074
Brugia malayi jmjC domain containing protein 0.044 0.6549 0.6549
Trypanosoma cruzi metacaspase, putative 0.0184 0.2515 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0024 0.0007 0.0008
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0709 0.0791
Loa Loa (eye worm) hypothetical protein 0.004 0.0255 0.0255
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0156 0.0593
Loa Loa (eye worm) hypothetical protein 0.0066 0.0662 0.0662
Echinococcus granulosus expressed protein 0.0066 0.0662 0.0738
Onchocerca volvulus 0.0028 0.0066 0.0113
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0066 0.0662 0.0662
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0565 0.063
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Onchocerca volvulus 0.0171 0.2316 0.4443
Onchocerca volvulus 0.0034 0.0169 0.0312
Leishmania major metacaspase, putative 0.0184 0.2515 0.706
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0028 0.0066 0.0074
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0184 0.2515 1
Echinococcus granulosus cathepsin l1 0.0034 0.0169 0.0189
Leishmania major hypothetical protein, conserved 0.004 0.0255 0.0696
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0345 0.1345
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0565 0.157
Brugia malayi intermediate filament protein 0.0029 0.0081 0.0081
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.025 0.3559 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0659 1 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0709 0.0791
Trypanosoma cruzi aminopeptidase, putative 0.0069 0.0709 0.2798
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0374 0.0417
Echinococcus multilocularis retinol dehydrogenase 11 0.0028 0.0066 0.0074
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0169 0.0312
Schistosoma mansoni regulator of G protein signaling 0.0066 0.0662 0.0662
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0575 0.0575
Plasmodium falciparum glutathione reductase 0.0097 0.1154 0.4572
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0944 0.1053
Loa Loa (eye worm) hypothetical protein 0.0084 0.0955 0.0955
Schistosoma mansoni caspase-7 (C14 family) 0.0485 0.7262 0.7262
Echinococcus granulosus oxidoreductase 0.0028 0.0066 0.0074
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0028 0.0066 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0374 0.0374
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0066 0.0066
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0066 0.0165
Brugia malayi hypothetical protein 0.012 0.152 0.152
Plasmodium vivax metacaspase 1, putative 0.0184 0.2515 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0066 0.0165
Brugia malayi hypothetical protein 0.0034 0.0167 0.0167
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0081 0.0081
Trypanosoma cruzi metacaspase, putative 0.0184 0.2515 1
Trypanosoma cruzi metacaspase 5, putative 0.0184 0.2515 1
Echinococcus granulosus caspase 0.0485 0.7262 0.81
Echinococcus multilocularis geminin 0.0525 0.7885 0.8795
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Loa Loa (eye worm) hypothetical protein 0.004 0.0255 0.0255
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Echinococcus multilocularis axis inhibition protein axin 0.0066 0.0662 0.0738
Echinococcus multilocularis muscleblind protein 0.0308 0.4467 0.4982
Trypanosoma brucei metacaspase 5, putative 0.0184 0.2515 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.049 0.1187
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0153 0.2038 0.8099
Brugia malayi jmjC domain containing protein 0.0084 0.0955 0.0955
Echinococcus granulosus muscleblind protein 0.0308 0.4467 0.4982
Echinococcus multilocularis Regulator of G protein signaling 20 0.0066 0.0662 0.0738
Plasmodium falciparum JmjC domain-containing protein, putative 0.0084 0.0955 0.3778
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0028 0.0066 0.0234
Leishmania major trypanothione reductase 0.0097 0.1154 0.3228
Brugia malayi Regulator of G protein signaling domain containing protein 0.0066 0.0662 0.0662
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0236 0.0911
Brugia malayi hypothetical protein 0.0171 0.2316 0.2316
Leishmania major cathepsin L-like protease 0.0034 0.0169 0.0456
Trypanosoma brucei short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Echinococcus granulosus lysosomal alpha glucosidase 0.0174 0.237 0.2644
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Onchocerca volvulus 0.0034 0.0169 0.0312
Toxoplasma gondii thioredoxin reductase 0.0097 0.1154 0.4572
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0565 0.063
Loa Loa (eye worm) oxidoreductase 0.0028 0.0066 0.0066
Mycobacterium tuberculosis Conserved protein 0.004 0.0255 0.0528
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1694 0.6726
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.0944 0.4451
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0234
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0222 0.312 0.312
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0028 0.0066 0.0066
Echinococcus multilocularis lysine specific demethylase 6a 0.0084 0.0955 0.1065
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0709 0.0791
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0066
Trypanosoma cruzi cruzipain precursor, putative 0.0131 0.1694 0.6726
Echinococcus multilocularis axis inhibition protein axin 0.0066 0.0662 0.0738
Leishmania major short chain dehydrogenase-like protein 0.0028 0.0066 0.0165
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0201 0.2792 0.3114
Echinococcus multilocularis muscleblind protein 1 0.0308 0.4467 0.4982
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0007 0.0007
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0236 0.0911
Loa Loa (eye worm) hypothetical protein 0.0091 0.1067 0.1067
Onchocerca volvulus 0.0028 0.0066 0.0113
Onchocerca volvulus 0.0069 0.0709 0.135
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0944 0.3735
Echinococcus granulosus phd:f box containing protein 0.0084 0.0955 0.1065
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0169 0.0189
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0255 0.0528
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0066 0.0165
Mycobacterium ulcerans carveol-like dehydrogenase 0.0028 0.0066 0.0165
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0153 0.2038 0.8099
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0169 0.0646
Brugia malayi Cell death protein 3 precursor 0.0354 0.5204 0.5204
Schistosoma mansoni lamin 0.0029 0.0081 0.0081
Schistosoma mansoni lamin 0.0029 0.0081 0.0081
Leishmania major short chain dehydrogenase, putative 0.0028 0.0066 0.0165
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0066 0.0662 0.0662
Echinococcus granulosus aminopeptidase N 0.0069 0.0709 0.0791
Loa Loa (eye worm) ctsf protein 0.0034 0.0169 0.0169
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0028 0.0066 0.0113
Schistosoma mansoni hypothetical protein 0.0525 0.7885 0.7885
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0028 0.0066 0.0234
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0066
Leishmania major hypothetical protein, conserved 0.0084 0.0955 0.2667
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0169 0.0189
Brugia malayi Cathepsin L-like precursor 0.0034 0.0169 0.0169
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0066 0.0165
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0565 0.2224
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.025 0.3559 1
Leishmania major hypothetical protein, conserved 0.0028 0.0066 0.0165
Trypanosoma cruzi metacaspase 5, putative 0.0184 0.2515 1
Mycobacterium tuberculosis Conserved protein 0.004 0.0255 0.0528
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0374 0.0374
Plasmodium vivax thioredoxin reductase, putative 0.0097 0.1154 0.4572
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.043 0.048
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0066 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.0659 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0169 0.0646
Trypanosoma cruzi short chain dehydrogenase, putative 0.0028 0.0066 0.0234
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0662 0.261
Schistosoma mansoni alpha-glucosidase 0.015 0.1988 0.1988
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0541 0.0541
Onchocerca volvulus 0.0028 0.0066 0.0113
Loa Loa (eye worm) hypothetical protein 0.0084 0.0944 0.0944
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0541 0.0604
Plasmodium falciparum glutathione reductase 0.0034 0.0156 0.0593
Schistosoma mansoni jumonji domain containing protein 0.04 0.5916 0.5916
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0255 0.0528
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0069 0.0709 0.0791
Loa Loa (eye worm) oxidoreductase 0.0028 0.0066 0.0066
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.237 0.2644
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0687 0.0687
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0066 0.0165
Loa Loa (eye worm) hypothetical protein 0.0232 0.328 0.328
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0066 0.0234
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0246 0.3498 0.9611
Echinococcus multilocularis inositol monophosphatase 1 0.0153 0.2038 0.2273
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1694 0.6726
Onchocerca volvulus 0.0034 0.0169 0.0312
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0255 0.0986
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0169 0.0189
Plasmodium falciparum phd finger protein, putative 0.006 0.0568 0.2237
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Echinococcus multilocularis oxidoreductase 0.0028 0.0066 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0374 0.0417
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0156 0.0593
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0066 0.0066
Loa Loa (eye worm) jmjC domain-containing protein 0.0124 0.1571 0.1571
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0169 0.0646
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.049 0.1187
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.1694 0.6726
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0066 0.0234
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0066 0.0662 0.0662
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0156 0.0418
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0593 0.8965 0.8965
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0285 0.1109
Loa Loa (eye worm) hypothetical protein 0.0184 0.2515 0.2515
Mycobacterium ulcerans ketoacyl reductase 0.0028 0.0066 0.0165
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0709 0.0791
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0169 0.0646
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0255 0.0528
Trypanosoma brucei short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Brugia malayi mbt repeat family protein 0.0051 0.043 0.043
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0944 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0234
Mycobacterium ulcerans dehydrogenase/reductase 0.0028 0.0066 0.0165
Loa Loa (eye worm) oxidoreductase 0.0028 0.0066 0.0066
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0169 0.0169
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0541 0.0604
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0255 0.0986
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0169 0.0646
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0028 0.0066 0.0234
Loa Loa (eye worm) inositol-1 0.0153 0.2038 0.2038
Onchocerca volvulus 0.0029 0.0081 0.0142
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Echinococcus multilocularis caspase 0.0485 0.7262 0.81
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Echinococcus multilocularis retinol dehydrogenase 11 0.0028 0.0066 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0169 0.0646
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0066
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0066 0.0165
Brugia malayi Dehydrogenases, short chain protein 2 0.0028 0.0066 0.0066
Loa Loa (eye worm) fibroinase 0.0034 0.0169 0.0169
Leishmania major short chain dehydrogenase/reductase, putative 0.0028 0.0066 0.0165
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0084 0.0955 0.0955
Echinococcus granulosus intermediate filament protein 0.0029 0.0081 0.009
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0944 1
Schistosoma mansoni aminopeptidase A (M01 family) 0.0024 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1694 0.6726
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Echinococcus multilocularis cysteine protease 0.0034 0.0169 0.0189
Trypanosoma cruzi trypanothione reductase, putative 0.0097 0.1154 0.4572
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0097 0.1154 0.3046
Echinococcus multilocularis regulator of G protein signaling 3 0.0066 0.0662 0.0738
Loa Loa (eye worm) dehydrogenase 0.0028 0.0066 0.0066
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0184 0.2515 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.012 0.1514 0.6011
Brugia malayi oxidoreductase 0.0028 0.0066 0.0066
Brugia malayi hypothetical protein 0.0028 0.0066 0.0066
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0069 0.0709 0.1975
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0169 0.0169
Trypanosoma brucei metacaspase 0.0184 0.2515 1
Plasmodium falciparum thioredoxin reductase 0.0034 0.0156 0.0593
Onchocerca volvulus 0.0034 0.0169 0.0312
Trypanosoma brucei oxidoreductase-like protein 0.0028 0.0066 0.0234
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0174 0.237 0.237
Brugia malayi regulator of G-protein signaling rgs-7 0.0066 0.0662 0.0662
Echinococcus multilocularis lamin dm0 0.0029 0.0081 0.009
Echinococcus granulosus Regulator of G protein signaling 20 0.0066 0.0662 0.0738
Mycobacterium ulcerans oxidoreductase 0.0028 0.0066 0.0165
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0066
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0153 0.2038 0.5718
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0184 0.2515 1
Echinococcus granulosus regulator of G protein signaling 3 0.0066 0.0662 0.0738
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0066 0.0234
Schistosoma mansoni hypothetical protein 0.0404 0.5992 0.5992
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0184 0.2515 1
Onchocerca volvulus 0.0069 0.0709 0.135
Schistosoma mansoni regulator of G protein signaling 0.0066 0.0662 0.0662
Schistosoma mansoni caspase-3 (C14 family) 0.0485 0.7262 0.7262
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0066 0.0165
Schistosoma mansoni hypothetical protein 0.006 0.0568 0.0568
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0234
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0184 0.2515 1
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0066 0.0234
Brugia malayi Peptidase family M1 containing protein 0.0069 0.0709 0.0709
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0171 0.2316 0.2316
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0066 0.0662 0.0738
Trypanosoma cruzi metacaspase, putative 0.0184 0.2515 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0137 0.1785 0.4815
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0028 0.0066 0.0165
Loa Loa (eye worm) hypothetical protein 0.012 0.152 0.152
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0285 0.1107
Brugia malayi Muscleblind-like protein 0.0308 0.4467 0.4467
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.2515 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0234
Echinococcus multilocularis transient receptor potential cation channel 0.0028 0.0066 0.0074
Echinococcus multilocularis apoptotic protease activating factor 1 0.0171 0.2316 0.2584
Entamoeba histolytica hypothetical protein 0.0066 0.0662 0.302
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0565 0.0565
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0086 0.098 0.1093
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0255 0.0284
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0285 0.4356
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.0156 0.0252
Toxoplasma gondii hypothetical protein 0.0029 0.0081 0.0292
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0028 0.0066 0.0066
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0028 0.0066 0.0234
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.025 0.3559 0.3559
Toxoplasma gondii carbonyl reductase 1, putative 0.0028 0.0066 0.0234
Plasmodium vivax steroid dehydrogenase, putative 0.0028 0.0066 0.0234
Giardia lamblia PHD finger protein 15 0.006 0.0568 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0709 0.0791
Onchocerca volvulus Cell death protein 3 homolog 0.0354 0.5204 1
Echinococcus multilocularis cysteine protease 0.0034 0.0169 0.0189
Loa Loa (eye worm) peptidase family M1 containing protein 0.0024 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1694 0.6726
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0541 0.0541
Brugia malayi jmjC domain containing protein 0.0084 0.0955 0.0955
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0372 0.0372
Toxoplasma gondii ABC1 family protein 0.004 0.0255 0.0986
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0184 0.2515 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0028 0.0066 0.0234
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0169 0.0646
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.1999 0.223
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0944 1
Onchocerca volvulus 0.0028 0.0066 0.0113
Echinococcus granulosus retinol dehydrogenase 11 0.0028 0.0066 0.0074
Brugia malayi hypothetical protein 0.0066 0.0662 0.0662
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0944 0.2637
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0236 0.0911
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0485 0.7262 0.81
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Brugia malayi Probable ClpP-like protease 0.0084 0.0944 0.0944
Onchocerca volvulus 0.0034 0.0169 0.0312
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0236 0.0643
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0169 0.0189
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Echinococcus granulosus steroid dehydrogenase 0.0028 0.0066 0.0074
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0169 0.0646
Echinococcus multilocularis musashi 0.0029 0.0081 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1694 0.6726
Plasmodium vivax vivapain-2 0.0034 0.0169 0.0646
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0236 0.086
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.043 0.043
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0028 0.0066 0.0234
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Echinococcus multilocularis regulator of G protein signaling 7 0.0066 0.0662 0.0738
Echinococcus granulosus cpg binding protein 0.003 0.0099 0.0111
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0067 0.0687 0.0687
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0201 0.2792 0.3114
Loa Loa (eye worm) hypothetical protein 0.0354 0.5204 0.5204
Leishmania major pteridine reductase 1 0.0028 0.0066 0.0165
Entamoeba histolytica cysteine protease, putative 0.0034 0.0169 0.0524
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0066 0.0165
Schistosoma mansoni caspase-7 (C14 family) 0.0354 0.5204 0.5204
Loa Loa (eye worm) hypothetical protein 0.012 0.152 0.152
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0221 0.3109 0.8523
Loa Loa (eye worm) hypothetical protein 0.004 0.0255 0.0255
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.5992 0.6683
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0184 0.2515 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0067 0.0687 0.0766
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.2515 1
Schistosoma mansoni axis inhibition protein axin 0.0066 0.0662 0.0662
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.049 0.1235
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0236 0.0236
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.328 0.3659
Plasmodium vivax hypothetical protein, conserved 0.006 0.0568 0.2237
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0169 0.0524
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0002 0.0002
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0028 0.0066 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0255 0.0986
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0169 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0662 0.261
Brugia malayi Bromodomain containing protein 0.0064 0.0628 0.0628
Loa Loa (eye worm) oxidoreductase 0.0028 0.0066 0.0066
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0568 0.2237
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0156 0.0593
Loa Loa (eye worm) hypothetical protein 0.004 0.0255 0.0255
Plasmodium vivax JmjC domain containing protein 0.0084 0.0955 0.3778
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0593 0.8965 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0028 0.0066 0.0234
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0255 0.0284
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0593 0.8965 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0156 0.0593
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0153 0.2038 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Brugia malayi dehydrogenases, short chain protein 2 0.0028 0.0066 0.0066
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0156 0.0456
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0345 0.0384
Echinococcus multilocularis cpg binding protein 0.003 0.0099 0.0111
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0246 0.3498 0.9611
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0568 0.2237
Brugia malayi Glycosyl hydrolases family 31 protein 0.0174 0.237 0.237
Loa Loa (eye worm) RGS-3 protein 0.0066 0.0662 0.0662
Mycobacterium ulcerans short-chain type oxidoreductase 0.0028 0.0066 0.0165
Leishmania major short chain dehydrogenase/reductase, putative 0.0028 0.0066 0.0165
Schistosoma mansoni survival motor neuron protein 0.0047 0.0372 0.0372
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Schistosoma mansoni jumonji/arid domain-containing protein 0.0318 0.4631 0.4631
Loa Loa (eye worm) hypothetical protein 0.0045 0.0328 0.0328
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0066 0.0074
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0236 0.0911
Onchocerca volvulus Sepiapterin reductase homolog 0.0028 0.0066 0.0113
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0221 0.3109 0.8523
Echinococcus granulosus geminin 0.0525 0.7885 0.8795
Loa Loa (eye worm) oxidoreductase 0.0028 0.0066 0.0066
Schistosoma mansoni regulator of G protein signaling 0.0066 0.0662 0.0662
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0345 0.1345
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0137 0.1785 0.501
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0236 0.0911
Brugia malayi hypothetical protein 0.0028 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0169 0.0646
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0169 0.0312
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0028 0.0066 0.0234
Mycobacterium leprae Probable lipase LipE 0.004 0.0255 0.0549
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0066 0.0165
Brugia malayi mbt repeat family protein 0.0051 0.043 0.043
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0255 0.0528
Brugia malayi beta-lactamase 0.004 0.0255 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0662 0.261
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0255 0.0986
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.049 0.0547
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0066 0.0165
Plasmodium falciparum metacaspase 1 0.0184 0.2515 1
Echinococcus multilocularis jumonji domain containing 1A 0.0084 0.0955 0.1065
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0066 0.0066
Echinococcus granulosus lysine specific demethylase 6a 0.0084 0.0955 0.1065
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0565 0.157
Loa Loa (eye worm) hypothetical protein 0.0066 0.0662 0.0662
Leishmania major hypothetical protein, conserved 0.0028 0.0066 0.0165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0169 0.0646
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0028 0.0066 0.0165
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.043 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.2515 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0045 0.0328 0.0366
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.2515 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0169 0.0646
Onchocerca volvulus 0.004 0.0255 0.0476
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.0156 0.0418
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0066 0.0074
Schistosoma mansoni alpha glucosidase 0.0039 0.0236 0.0236
Mycobacterium tuberculosis Conserved protein 0.004 0.0255 0.0528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0169 0.0646
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0169 0.0646
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0028 0.0066 0.0074
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0069 0.0709 0.2798
Loa Loa (eye worm) jmjC domain-containing protein 0.0084 0.0955 0.0955
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0593 0.8965 0.8965
Schistosoma mansoni jumonji/arid domain-containing protein 0.0318 0.4631 0.4631
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.328 0.3659
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0028 0.0066 0.0234
Brugia malayi Peptidase family M1 containing protein 0.0069 0.0709 0.0709
Echinococcus granulosus beta-adrenergic receptor kinase 0.0067 0.0687 0.0766
Echinococcus multilocularis lysine specific demethylase 5A 0.0316 0.4606 0.5137
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.025 0.3559 0.397
Loa Loa (eye worm) hypothetical protein 0.0084 0.0955 0.0955
Echinococcus granulosus regulator of G protein signaling 3 0.0066 0.0662 0.0738
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0066 0.0074
Schistosoma mansoni regulator of G protein signaling 0.0066 0.0662 0.0662
Mycobacterium ulcerans short-chain dehydrogenase 0.0028 0.0066 0.0165
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0236 0.0911
Trichomonas vaginalis inositol monophosphatase, putative 0.0153 0.2038 0.8099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0169 0.0646
Onchocerca volvulus 0.0028 0.0066 0.0113
Trypanosoma brucei metacaspase MCA3 0.0184 0.2515 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.237 0.2644
Schistosoma mansoni carbonyl reductase 0.0028 0.0066 0.0066
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0156 0.0156
Leishmania major short chain dehydrogenase, putative 0.0028 0.0066 0.0165
Onchocerca volvulus Alhambra homolog 0.006 0.0568 0.1079
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0028 0.0066 0.0234
Schistosoma mansoni cpg binding protein 0.0028 0.0074 0.0074
Mycobacterium tuberculosis Probable oxidoreductase 0.0246 0.3498 0.9611
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.025 0.3559 0.397
Echinococcus multilocularis thioredoxin glutathione reductase 0.0097 0.1154 0.1287
Onchocerca volvulus 0.0028 0.0066 0.0113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1694 0.6726
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Brugia malayi hypothetical protein 0.0232 0.328 0.328
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0236 0.0911
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0066 0.0066
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0156 0.0593
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0153 0.2038 1
Echinococcus multilocularis conserved hypothetical protein 0.0028 0.0066 0.0074
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0045 0.0328 0.0328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0169 0.0646
Loa Loa (eye worm) thioredoxin reductase 0.0097 0.1154 0.1154
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0944 0.3735
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0169 0.0646
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0066 0.0066
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0028 0.0066 0.0074
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0028 0.0066 0.0234
Loa Loa (eye worm) hypothetical protein 0.0066 0.0662 0.0662
Trypanosoma brucei glucosidase, putative 0.0039 0.0236 0.0911
Mycobacterium tuberculosis Probable reductase 0.0221 0.3109 0.8523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0169 0.0646
Onchocerca volvulus Huntingtin homolog 0.012 0.152 0.291
Loa Loa (eye worm) hypothetical protein 0.0066 0.0662 0.0662
Brugia malayi Cathepsin L-like precursor 0.0034 0.0169 0.0169
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0156 0.0593
Onchocerca volvulus 0.0028 0.0066 0.0113
Schistosoma mansoni retinal dehydrogenase 0.0028 0.0066 0.0066
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0593 0.8965 0.8965
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0565 0.157
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0066 0.0662 0.261
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0169 0.0169
Loa Loa (eye worm) cysteine protease 0.0034 0.0169 0.0169
Loa Loa (eye worm) jmjC domain-containing protein 0.0084 0.0955 0.0955
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.2515 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0028 0.0066 0.0165
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0156 0.0593
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0374 0.0374
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Leishmania major hypothetical protein, conserved 0.0053 0.0463 0.1283
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0028 0.0066 0.0066
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0463 0.1817
Echinococcus multilocularis steroid dehydrogenase 0.0028 0.0066 0.0074
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0066 0.0165
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0028 0.0066 0.0074
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0184 0.2515 0.2515
Onchocerca volvulus 0.0101 0.1214 0.2321
Loa Loa (eye worm) hypothetical protein 0.004 0.0255 0.0255
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0084 0.0955 0.3778
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0236 0.0263
Leishmania major cathepsin L-like protease 0.0034 0.0169 0.0456
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0374 0.0417
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0028 0.0066 0.0234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0255 0.0255
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.044 0.6549 0.7305
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0236 0.0911
Loa Loa (eye worm) MBCTL1 0.0058 0.0541 0.0541
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0541 0.0604
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0156 0.0593
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0028 0.0066 0.0234
Trypanosoma brucei short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Brugia malayi PXA domain containing protein 0.0066 0.0662 0.0662
Echinococcus granulosus thioredoxin glutathione reductase 0.0097 0.1154 0.1287
Loa Loa (eye worm) glutathione reductase 0.0097 0.1154 0.1154
Toxoplasma gondii cathepsin CPL 0.0034 0.0169 0.0646
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0374 0.0374
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Toxoplasma gondii oxidoreductase, putative 0.0028 0.0066 0.0234
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0028 0.0066 0.0234
Mycobacterium ulcerans dehydrogenase 0.0028 0.0066 0.0165
Mycobacterium ulcerans lipase LipD 0.004 0.0255 0.0696
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0066 0.0165
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0944 0.0944
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0236 0.086
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0255 0.0255
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0002 0.0002
Onchocerca volvulus 0.0028 0.0066 0.0113
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0028 0.0066 0.0234
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.0156 0.0418
Trypanosoma cruzi major cysteine proteinase, putative 0.0103 0.1251 0.4962
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0169 0.0646
Echinococcus granulosus dnaJ subfamily B 0.0404 0.5992 0.6683
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0565 0.0565
Onchocerca volvulus Huntingtin homolog 0.012 0.152 0.291
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0255 0.0528
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0255 0.0986
Plasmodium falciparum thioredoxin reductase 0.0097 0.1154 0.4572
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.0937 0.1045
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0169 0.0646
Brugia malayi PXA domain containing protein 0.0066 0.0662 0.0662
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0084 0.0955 0.3778
Echinococcus multilocularis JmjC domain containing protein 4 0.0084 0.0955 0.1065
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0184 0.2515 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0084 0.0955 0.3778
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0255 0.0696
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0221 0.3109 0.8523
Brugia malayi Inositol-1 0.0153 0.2038 0.2038
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0066 0.0234
Loa Loa (eye worm) dehydrogenase 0.0028 0.0066 0.0066
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Mycobacterium ulcerans short-chain dehydrogenase 0.0028 0.0066 0.0165
Echinococcus granulosus regulator of G protein signaling 7 0.0066 0.0662 0.0738
Trypanosoma brucei Metacaspase-4 0.0184 0.2515 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0081 0.0081
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0066 0.0662 0.0662
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0091 0.1067 0.5074
Loa Loa (eye worm) hypothetical protein 0.006 0.0568 0.0568
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0255 0.0255
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0156 0.0174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0169 0.0646
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0236 0.0911
Echinococcus granulosus inositol monophosphatase 1 0.0153 0.2038 0.2273
Echinococcus granulosus regulator of G protein signaling 7 0.0066 0.0662 0.0738
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.004 0.0255 0.0255
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0069 0.0709 0.0709
Leishmania major hypothetical protein, conserved 0.0028 0.0066 0.0165
Schistosoma mansoni carbonyl reductase 0.0028 0.0066 0.0066
Onchocerca volvulus 0.0028 0.0066 0.0113
Loa Loa (eye worm) hypothetical protein 0.0308 0.4467 0.4467
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Trypanosoma cruzi metacaspase, putative 0.0184 0.2515 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.0156 0.0418
Brugia malayi Regulator of G protein signaling domain containing protein 0.0066 0.0662 0.0662
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0084 0.0955 0.3778
Brugia malayi Cathepsin L-like precursor 0.0034 0.0169 0.0169
Onchocerca volvulus 0.0034 0.0169 0.0312
Schistosoma mansoni cpg binding protein 0.003 0.0099 0.0099
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0028 0.0066 0.0066
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.043 0.048
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0028 0.0066 0.0165
Brugia malayi hypothetical protein 0.0024 0.0007 0.0007
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0156 0.0174
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0153 0.2038 0.8099
Onchocerca volvulus 0.0051 0.043 0.0814
Mycobacterium ulcerans ketoacyl reductase 0.0028 0.0066 0.0165
Loa Loa (eye worm) hypothetical protein 0.0168 0.2265 0.2265
Trypanosoma brucei trypanothione reductase 0.0097 0.1154 0.4572
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.025 0.3559 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0156 0.0593
Leishmania major cathepsin L-like protease 0.0131 0.1694 0.4749
Schistosoma mansoni protein phosphatase 2C 0.0084 0.0955 0.0955
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0169 0.0189
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0944 0.3735
Brugia malayi jmjC domain containing protein 0.0084 0.0955 0.0955
Mycobacterium ulcerans aminopeptidase N PepN 0.0069 0.0709 0.1975
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0236 0.0911
Brugia malayi Dehydrogenases, short chain protein 30 0.0028 0.0066 0.0066
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0066 0.0066
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0153 0.2038 0.8099
Trypanosoma brucei metacaspase MCA2 0.0184 0.2515 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0153 0.2038 0.5718
Trypanosoma cruzi Aminopeptidase M1, putative 0.0069 0.0709 0.2798
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0169 0.0646
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0066 0.0074
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0184 0.2515 0.2515
Mycobacterium ulcerans short-chain dehydrogenase 0.0028 0.0066 0.0165
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0028 0.0066 0.0113
Echinococcus granulosus lamin 0.0029 0.0081 0.009
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0345 0.1345
Loa Loa (eye worm) oxidoreductase 0.0028 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0053 0.0463 0.0463
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0463 0.1817
Entamoeba histolytica hypothetical protein 0.0066 0.0662 0.302
Brugia malayi dehydrogenases, short chain protein 9 0.0028 0.0066 0.0066
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0565 0.1397
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0081 0.0042
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0028 0.0066 0.0234
Brugia malayi hypothetical protein 0.0053 0.0463 0.0463
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0028 0.0066 0.0234
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0081 0.0292
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0066 0.0165
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0066 0.0165
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0016 0.0016
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Echinococcus multilocularis caspase 2 0.0354 0.5204 0.5805
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0156 0.0593
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0156 0.0593
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1694 0.6726
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0169 0.0456
Loa Loa (eye worm) beta-lactamase 0.004 0.0255 0.0255
Echinococcus granulosus axis inhibition protein axin 0.0066 0.0662 0.0738
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1694 0.6726
Onchocerca volvulus 0.0047 0.0372 0.0702
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.2068 0.2068
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0066 0.0066
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Loa Loa (eye worm) oxidoreductase 0.0028 0.0066 0.0066
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0345 0.1345
Loa Loa (eye worm) PXA domain-containing protein 0.0066 0.0662 0.0662
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0086 0.098 0.1093
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.2515 1
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Echinococcus granulosus retinol dehydrogenase 11 0.0028 0.0066 0.0074
Treponema pallidum NADH oxidase 0.0034 0.0156 0.0873
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0169 0.0524
Schistosoma mansoni axis inhibition protein axin 0.0066 0.0662 0.0662
Brugia malayi regulator of G-protein signaling egl-10 0.0066 0.0662 0.0662
Brugia malayi Thioredoxin reductase 0.0097 0.1154 0.1154
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0156 0.0418
Echinococcus granulosus apoptotic protease activating factor 1 0.0171 0.2316 0.2584
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.043 0.043
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0069 0.0709 0.2798
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0091 0.1067 0.5074
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0255 0.0528
Trypanosoma brucei short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1694 0.6726
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0066 0.0074
Brugia malayi Retinol dehydrogenase 12 0.0028 0.0066 0.0066
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.1694 0.6726
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0345 0.1345
Echinococcus granulosus lysine specific demethylase 5A 0.0318 0.4631 0.5166
Leishmania major 3-keto-dihydrosphingosine reductase 0.0028 0.0066 0.0165
Schistosoma mansoni hypothetical protein 0.0024 0.0002 0.0002
Onchocerca volvulus 0.0029 0.0081 0.0142
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0156 0.1789
Echinococcus multilocularis expressed protein 0.0066 0.0662 0.0738
Brugia malayi jmjC domain containing protein 0.0084 0.0955 0.0955
Loa Loa (eye worm) TATA binding protein associated factor 0.0024 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0662 0.261
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0944 0.2637
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0374 0.0417
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0066 0.0662 0.0662
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0024 0.0007 0.0007
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0024 0.0007 0.0007
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0568 0.0568
Leishmania major dehydrogenase-like protein 0.0028 0.0066 0.0165
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0066 0.0066
Brugia malayi Cathepsin L-like precursor 0.0034 0.0169 0.0169
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0236 0.0236
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Trypanosoma cruzi short chain dehydrogenase, putative 0.0028 0.0066 0.0234
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0156 0.0156
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0045 0.0328 0.1281
Echinococcus multilocularis peregrin 0.0064 0.0628 0.07
Entamoeba histolytica aminopeptidase, putative 0.0069 0.0709 0.326
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0255 0.0986
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.043 0.048
Mycobacterium leprae conserved hypothetical protein 0.004 0.0255 0.0549
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0084 0.0955 0.3778
Loa Loa (eye worm) hypothetical protein 0.0045 0.0328 0.0328
Loa Loa (eye worm) jmjC domain-containing protein 0.0084 0.0955 0.0955
Brugia malayi hypothetical protein 0.0066 0.0662 0.0662
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.1694 0.6726
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Onchocerca volvulus 0.004 0.0255 0.0476
Brugia malayi glutathione reductase 0.0097 0.1154 0.1154
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0016 0.0016
Trypanosoma brucei Aminopeptidase M1, putative 0.0069 0.0709 0.2798
Schistosoma mansoni hypothetical protein 0.0047 0.0372 0.0372
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0184 0.2515 1
Schistosoma mansoni hypothetical protein 0.031 0.451 0.451
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0156 0.0418
Schistosoma mansoni hypothetical protein 0.0171 0.2316 0.2316
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0944 0.3735
Loa Loa (eye worm) acetyltransferase 0.0155 0.2068 0.2068
Echinococcus granulosus hypothetical protein 0.0028 0.0066 0.0074
Brugia malayi beta-lactamase family protein 0.004 0.0255 0.0255
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0709 0.0791
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0028 0.0066 0.0234
Echinococcus granulosus lamin dm0 0.0029 0.0081 0.009
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.043 0.0814
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.2068 0.2068
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.025 0.3559 0.9782
Loa Loa (eye worm) jmjC domain-containing protein 0.0318 0.4631 0.4631
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0184 0.2515 1
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0028 0.0066 0.0234
Entamoeba histolytica hypothetical protein 0.0066 0.0662 0.302
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0255 0.0255
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.025 0.3559 0.3559
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0069 0.0709 0.2798
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Leishmania major cathepsin L-like protease 0.0034 0.0169 0.0456
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0066 0.0662 0.0738
Echinococcus granulosus caspase 8 0.0184 0.2515 0.2805
Onchocerca volvulus 0.004 0.0255 0.0476
Echinococcus multilocularis regulator of G protein signaling 0.0066 0.0662 0.0738
Echinococcus multilocularis regulator of G protein signaling 3 0.0066 0.0662 0.0738
Trichomonas vaginalis steroid dehydrogenase, putative 0.0028 0.0066 0.0234
Schistosoma mansoni jumonji domain containing protein 0.0084 0.0955 0.0955
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0066
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0463 0.1817
Loa Loa (eye worm) hypothetical protein 0.0051 0.043 0.043
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Brugia malayi beta-lactamase family protein 0.004 0.0255 0.0255
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.043 0.043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1694 0.6726
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0709 0.0791
Loa Loa (eye worm) oxidoreductase 0.0028 0.0066 0.0066
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0246 0.3498 1
Echinococcus multilocularis caspase 3 0.0302 0.4374 0.4879
Mycobacterium ulcerans hypothetical protein 0.004 0.0255 0.0696
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0662 0.261
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0153 0.2038 0.8099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0169 0.0646
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Trichomonas vaginalis esterase, putative 0.004 0.0255 0.0986
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0169 0.0169
Schistosoma mansoni alpha-glucosidase 0.015 0.1988 0.1988
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0028 0.0066 0.0234
Loa Loa (eye worm) aminopeptidase N 0.0069 0.0709 0.0709
Brugia malayi TATA binding protein associated factor 0.0024 0.0007 0.0007
Onchocerca volvulus 0.0028 0.0066 0.0113
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0221 0.3109 0.8868
Brugia malayi PHD-finger family protein 0.006 0.0568 0.0568
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0066 0.0165
Schistosoma mansoni phd/f-box containing protein 0.0084 0.0955 0.0955
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0069 0.0709 0.2798
Schistosoma mansoni intermediate filament proteins 0.0029 0.0081 0.0081
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0028 0.0066 0.0165
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0236 0.0263
Toxoplasma gondii oxidoreductase, putative 0.0028 0.0066 0.0234
Leishmania major cathepsin L-like protease 0.0131 0.1694 0.4749
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0069 0.0709 0.0709
Plasmodium vivax hypothetical protein, conserved 0.0184 0.2515 1
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0066 0.0234
Echinococcus multilocularis lamin 0.0029 0.0081 0.009
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0028 0.0066 0.0113
Schistosoma mansoni inositol monophosphatase 0.0153 0.2038 0.2038
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0156 0.0418
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0255 0.0986
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0221 0.3109 0.8523
Plasmodium vivax hypothetical protein, conserved 0.004 0.0255 0.0986
Mycobacterium ulcerans ketoacyl reductase 0.0028 0.0066 0.0165
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0066 0.0066
Echinococcus granulosus caspase 2 0.0354 0.5204 0.5805
Plasmodium falciparum steroid dehydrogenase, putative 0.0028 0.0066 0.0234
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0028 0.0066 0.0234
Onchocerca volvulus 0.0028 0.0066 0.0113
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0234
Brugia malayi hypothetical protein 0.0069 0.0709 0.0709
Echinococcus granulosus jumonji domain containing protein 0.0083 0.0937 0.1045
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0944 0.1053
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0255 0.0528
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0156 0.0456
Echinococcus granulosus hypothetical protein 0.0028 0.0066 0.0074
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0153 0.2038 0.8099
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0028 0.0066 0.0066
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0156 0.0593
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0169 0.0646
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0944 0.2557
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0156 0.0593
Echinococcus multilocularis caspase 8 0.0184 0.2515 0.2805
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.044 0.6549 0.7305
Brugia malayi Cathepsin L-like precursor 0.0034 0.0169 0.0169
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0066 0.0066
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0709 0.0791
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0028 0.0066 0.0234
Echinococcus multilocularis regulator of G protein signaling 7 0.0066 0.0662 0.0738
Leishmania major cathepsin L-like protease 0.0034 0.0169 0.0456
Echinococcus multilocularis steroid dehydrogenase 0.0028 0.0066 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0169 0.0646
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0568 0.0634
Echinococcus granulosus WW domain containing oxidoreductase 0.0028 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0308 0.4467 0.4467
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0028 0.0066 0.0074
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0081 0.0292
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0463 0.1817
Brugia malayi A-kinase anchor protein 10, precursor 0.0066 0.0662 0.0662
Plasmodium vivax glutathione reductase, putative 0.0097 0.1154 0.4572
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0066 0.0234
Leishmania major cathepsin L-like protease 0.0131 0.1694 0.4749
Echinococcus granulosus peregrin 0.0064 0.0628 0.07
Echinococcus multilocularis aminopeptidase N 0.0069 0.0709 0.0791
Loa Loa (eye worm) hypothetical protein 0.0045 0.0328 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0169 0.0646
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0156 0.0593
Loa Loa (eye worm) oxidoreductase 0.0028 0.0066 0.0066
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0058 0.0541 0.0541
Schistosoma mansoni phosphatidylserine receptor 0.0084 0.0955 0.0955
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0565 0.157
Schistosoma mansoni regulator of G protein signaling 0.0066 0.0662 0.0662
Trypanosoma brucei short-chain dehydrogenase, putative 0.0028 0.0066 0.0234
Leishmania major oxidoreductase-like protein 0.0028 0.0066 0.0165
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0255 0.0986
Schistosoma mansoni inositol monophosphatase 0.0153 0.2038 0.2038
Loa Loa (eye worm) hypothetical protein 0.0066 0.0662 0.0662
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.0525 0.7885 0.7885
Onchocerca volvulus 0.0028 0.0066 0.0113
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0169 0.0189
Schistosoma mansoni carbonyl reductase 0.0028 0.0066 0.0066
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.043 0.048
Loa Loa (eye worm) hypothetical protein 0.0034 0.0169 0.0169
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0024 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.0081
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0028 0.0066 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1694 0.6726
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0069 0.0709 0.1975
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0071 0.0071
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0066 0.0165
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0255 0.0696
Echinococcus granulosus leukotriene A 4 hydrolase 0.0024 0.0007 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0169 0.0646

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 112.53 % Cytotoxicity against human DU145 cells at 10 uM after 48 hrs by sulforhodamine B assay relative to control ChEMBL. 24094433

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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