Detailed information for compound 591307

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 615.587 | Formula: C28H27F6N3O4S
  • H donors: 3 H acceptors: 4 LogP: 3.65 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.CC(=O)Nc1ccc(cc1)CN1CCC(CC1)NC(=O)c1ccc(s1)c1cccc(c1)C(F)(F)F
  • InChi: 1S/C26H26F3N3O2S.C2HF3O2/c1-17(33)30-21-7-5-18(6-8-21)16-32-13-11-22(12-14-32)31-25(34)24-10-9-23(35-24)19-3-2-4-20(15-19)26(27,28)29;3-2(4,5)1(6)7/h2-10,15,22H,11-14,16H2,1H3,(H,30,33)(H,31,34);(H,6,7)
  • InChiKey: ZYNCIWXEDSKRIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad 0.0026 0.0007 0.0012
Entamoeba histolytica acetyltransferase, GNAT family 0.0023 0.0006 0.1958
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.0075 0.0117
Echinococcus granulosus tachykinin peptides receptor 99D 0.0072 0.0033 0.0051
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Loa Loa (eye worm) G-protein coupled receptor 0.0072 0.0033 0.0033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.0033 0.0051
Echinococcus multilocularis neutral alpha glucosidase AB 0.0021 0.0005 0.0007
Schistosoma mansoni vesicular amine transporter 0.0023 0.0005 0.0008
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0017 0.0002 0.0003
Brugia malayi Glutamate receptor 2 precursor 0.0192 0.01 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0036 0.0036
Leishmania major protein kinase A regulatory subunit, putative 0.0017 0.0002 0.0002
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0029 0.0009 0.0837
Echinococcus granulosus neuropeptides capa receptor 0.0072 0.0033 0.0051
Schistosoma mansoni neuropeptide F-like receptor 0.0072 0.0033 0.0051
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0029 0.0009 0.0014
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.001 0.0879
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0072 0.0033 0.0051
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0003 0.0047
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0005 0.0435
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0254 0.0134 0.0209
Trypanosoma brucei Flagellar Member 6 0.0017 0.0002 0.0002
Brugia malayi hypothetical protein 0.0072 0.0033 0.0033
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0039 0.0014 0.0022
Echinococcus granulosus sodium and chloride dependent glycine 0.0868 0.0475 0.0742
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.0033 0.0051
Onchocerca volvulus 0.0072 0.0033 0.0047
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0185 0.0095 0.0149
Onchocerca volvulus 0.0072 0.0033 0.0047
Echinococcus multilocularis lysosomal alpha glucosidase 0.0097 0.0046 0.0072
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0017 0.0002 0.0201
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0017 0.0002 0.0003
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0474 0.0256 0.04
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0006 0.0006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0002 0.0201
Trypanosoma cruzi extracellular receptor, putative 0.0061 0.0027 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0003 0.0022
Toxoplasma gondii target of rapamycin (TOR), putative 0.0029 0.0009 0.0788
Loa Loa (eye worm) RGC/RGC protein kinase 0.0061 0.0027 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.001 0.001
Onchocerca volvulus 0.0079 0.0036 0.0054
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0185 0.0095 0.0149
Echinococcus multilocularis serotonin transporter 0.0282 0.015 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0009 0.0825
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0004 0.0412
Echinococcus multilocularis G-protein coupled receptor, putative 0.0072 0.0033 0.0051
Schistosoma mansoni transient receptor potential channel 0.009 0.0043 0.0067
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0017 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0758 0.0413 0.0646
Loa Loa (eye worm) hypothetical protein 0.0061 0.0027 0.0027
Onchocerca volvulus 0.0079 0.0036 0.0054
Echinococcus granulosus serotonin receptor 0.0072 0.0033 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0006 0.053
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0036 0.1271
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Schistosoma mansoni neuropeptide receptor 0.0072 0.0033 0.0051
Echinococcus granulosus neuropeptide receptor A26 0.0233 0.0122 0.0191
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.0007 0.0012
Brugia malayi Calcitonin receptor-like protein seb-1 0.0221 0.0116 0.0116
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.001 0.4906
Brugia malayi MH1 domain containing protein 0.0015 0.0001 0.0001
Echinococcus granulosus vesicular acetylcholine transporter 1.1541 0.6401 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Echinococcus multilocularis dnaJ subfamily B 0.034 0.0181 0.0283
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.0033 0.0051
Echinococcus multilocularis smad 0.0026 0.0007 0.0012
Echinococcus granulosus transient receptor potential gamma protein 0.009 0.0043 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.0007 0.0012
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0015 0.0024
Mycobacterium ulcerans lipase LipD 0.0079 0.0036 0.2755
Mycobacterium ulcerans hypothetical protein 0.0079 0.0036 0.2755
Onchocerca volvulus Neuropeptide F receptor homolog 0.0072 0.0033 0.0047
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0003 0.0022
Loa Loa (eye worm) RGC/RGC protein kinase 0.0061 0.0027 0.0027
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0036 0.0036
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.001 0.066
Schistosoma mansoni transient receptor potential channel 0.0063 0.0028 0.0043
Leishmania major extracellular receptor, putative 0.0061 0.0027 0.0027
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0015 0.0015
Echinococcus granulosus TRP transient receptor potential channel 0.004 0.0015 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0002 0.0201
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.0054 0.0084
Schistosoma mansoni ap endonuclease 0.0041 0.0015 0.0024
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0017 0.0002 0.0002
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0003 0.0047
Echinococcus multilocularis nmda type glutamate receptor 0.0266 0.0141 0.022
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0232 0.0121 0.4429
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0185 0.0095 0.0149
Brugia malayi metabotropic glutamate receptor type 2 0.0061 0.0027 0.0027
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0009 0.0825
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0185 0.0095 0.0095
Echinococcus multilocularis sodium and chloride dependent glycine 0.0868 0.0475 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0009 0.0825
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0241 0.0126 0.4613
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0221 0.0116 0.0116
Schistosoma mansoni ATP-binding cassette transporter 0.0192 0.01 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.001 0.093
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0003 0.0022
Onchocerca volvulus 0.0061 0.0027 0.0039
Schistosoma mansoni hypothetical protein 0.0072 0.0033 0.0051
Brugia malayi Latrophilin receptor protein 2 0.007 0.0032 0.0032
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0072 0.0033 0.0051
Echinococcus granulosus dro:myosuppressin receptor 0.0072 0.0033 0.0051
Loa Loa (eye worm) melatonin receptor type 1A 0.0072 0.0033 0.0033
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0079 0.0036 0.0036
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.001 0.001
Echinococcus multilocularis lamin dm0 0.0022 0.0005 0.0008
Brugia malayi MH2 domain containing protein 0.0026 0.0007 0.0007
Mycobacterium leprae Probable lipase LipE 0.0079 0.0036 0.287
Echinococcus multilocularis GPCR, family 2 0.007 0.0032 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0036 0.3404
Loa Loa (eye worm) hypothetical protein 0.0026 0.0007 0.0007
Echinococcus multilocularis tyrosine kinase 0.0061 0.0027 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0009 0.0825
Echinococcus granulosus G protein coupled receptor 139 0.0072 0.0033 0.0051
Leishmania major hypothetical protein, conserved 0.0238 0.0125 0.0125
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0012 0.0012
Schistosoma mansoni amine GPCR 0.0072 0.0033 0.0051
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0036 0.0057
Toxoplasma gondii thioredoxin reductase 0.0091 0.0044 0.4476
Echinococcus multilocularis hyperpolarization activated cyclic 0.0029 0.0009 0.0014
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0003 0.0047
Onchocerca volvulus 0.0072 0.0033 0.0047
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0017 0.0002 0.0003
Echinococcus multilocularis neuropeptide receptor 0.0072 0.0033 0.0051
Brugia malayi hypothetical protein 0.0072 0.0033 0.0033
Echinococcus granulosus glutamate receptor NMDA 0.0205 0.0107 0.0166
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0025 0.0007 0.001
Echinococcus granulosus sex peptide receptor 0.0072 0.0033 0.0051
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0061 0.0027 0.0027
Mycobacterium tuberculosis Conserved protein 0.0079 0.0036 0.1271
Brugia malayi intermediate filament protein 0.0022 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Loa Loa (eye worm) RGC/RGC protein kinase 0.0061 0.0027 0.0027
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0185 0.0095 0.0149
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0007 0.0012
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0185 0.0095 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0072 0.0033 0.0051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0148 0.0075 0.0075
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0072 0.0033 0.0051
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0038 0.0038
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0072 0.0033 0.0051
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0072 0.0033 0.0033
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0185 0.0095 0.0149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0033 0.0051
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0003 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0036 0.3404
Echinococcus multilocularis importin subunit beta 1 0.0017 0.0002 0.0004
Schistosoma mansoni amine GPCR 0.0072 0.0033 0.0051
Trypanosoma brucei cAMP binding protein, putative 0.0017 0.0002 0.0002
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0036 0.1271
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.001 0.0949
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0003 0.0022
Brugia malayi G protein-coupled receptor 0.0072 0.0033 0.0033
Schistosoma mansoni biogenic amine receptor 0.0072 0.0033 0.0051
Loa Loa (eye worm) hypothetical protein 0.0061 0.0027 0.0027
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0003 0.0047
Echinococcus multilocularis g protein coupled receptor 0.0072 0.0033 0.0051
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0017 0.0002 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0091 0.0044 0.0044
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0072 0.0033 0.0033
Brugia malayi Tachykinin-like peptides receptor 99D 0.0072 0.0033 0.0033
Loa Loa (eye worm) AGC/PKG protein kinase 0.0017 0.0002 0.0002
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0072 0.0033 0.0051
Echinococcus granulosus fmrfamide receptor 0.0072 0.0033 0.0051
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0003 0.0022
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0025 0.004
Brugia malayi vesicular acetylcholine transporter unc-17 1.1541 0.6401 0.6401
Toxoplasma gondii histone lysine methyltransferase SET1 0.0048 0.002 0.1926
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.013 0.0065 0.0102
Loa Loa (eye worm) Smad1 0.0026 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0006 0.053
Onchocerca volvulus 0.0056 0.0024 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0014 0.1343
Entamoeba histolytica hypothetical protein 0.0023 0.0006 0.1948
Echinococcus granulosus glutamate receptor 2 0.0123 0.0061 0.0096
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0012 0.0756
Loa Loa (eye worm) serotonin transporter b 0.0282 0.015 0.015
Brugia malayi AKH receptor 0.0072 0.0033 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0009 0.0014
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0232 0.0121 0.4429
Trichomonas vaginalis bromodomain-containing protein, putative 0.0025 0.0007 0.0634
Schistosoma mansoni biogenic amine (5HT) receptor 0.0072 0.0033 0.0051
Brugia malayi hypothetical protein 0.0072 0.0033 0.0033
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0185 0.0095 0.0095
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.013 0.0065 0.0102
Plasmodium falciparum importin beta, putative 0.0017 0.0002 0.001
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Echinococcus granulosus Smad4 0.0026 0.0007 0.0012
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0072 0.0033 0.0033
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0003 0.0003
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0003 0.0047
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0006 0.001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0072 0.0033 0.0051
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0029 0.0009 0.0014
Echinococcus granulosus allatostatin A receptor 0.0072 0.0033 0.0051
Plasmodium vivax amine transporter, putative 0.0185 0.0095 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0006 0.0006
Echinococcus granulosus patatin phospholipase domain containing protein 0.0017 0.0002 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0003 0.0022
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0006 0.0006
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0025 0.0863
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0282 0.015 0.0234
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.007 0.0032 0.0032
Echinococcus multilocularis lamin 0.0022 0.0005 0.0008
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0017 0.0002 0.0201
Loa Loa (eye worm) hypothetical protein 0.0185 0.0095 0.0095
Echinococcus multilocularis musashi 0.0022 0.0005 0.0008
Plasmodium falciparum amino acid transporter, putative 0.0185 0.0095 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0028 0.0043
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0185 0.0095 0.7508
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0031 0.001 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0003 0.0003
Brugia malayi putative neuropeptide receptor 0.0072 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0185 0.0095 0.0095
Schistosoma mansoni hypothetical protein 0.007 0.0032 0.0049
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.001 0.0967
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0254 0.0134 0.0209
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0029 0.0009 0.0014
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0003 0.0047
Trypanosoma brucei glucosidase, putative 0.0021 0.0005 0.0005
Echinococcus granulosus peptide allatostatin:somatostatin 0.0072 0.0033 0.0051
Schistosoma mansoni hypothetical protein 0.007 0.0032 0.0049
Chlamydia trachomatis glutamine binding protein 0.0241 0.0126 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0072 0.0033 0.0051
Onchocerca volvulus 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.001 0.001
Brugia malayi Smad1 0.0026 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0005 0.0005
Echinococcus multilocularis neuropeptides capa receptor 0.0072 0.0033 0.0051
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0072 0.0033 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0033 0.0051
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0003 0.0022
Schistosoma mansoni ap endonuclease 0.0041 0.0015 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0036 0.3404
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0036 0.0036
Plasmodium vivax thioredoxin reductase, putative 0.0091 0.0044 0.4433
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.0007 0.0636
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0025 0.004
Echinococcus multilocularis geminin 0.0758 0.0413 0.0646
Echinococcus granulosus cGMP dependent protein kinase 0.0017 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0026 0.0007 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0009 0.0825
Loa Loa (eye worm) hypothetical protein 0.0337 0.018 0.018
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0072 0.0033 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0009 0.0825
Brugia malayi CXXC zinc finger family protein 0.0024 0.0006 0.0006
Echinococcus multilocularis thioredoxin glutathione reductase 0.0092 0.0044 0.0068
Trypanosoma cruzi C-8 sterol isomerase, putative 1.8023 1 1
Echinococcus granulosus somatostatin receptor 0.0072 0.0033 0.0051
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0007 0.0007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0036 0.1271
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0259 0.0136 0.0136
Echinococcus multilocularis sex peptide receptor 0.0072 0.0033 0.0051
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0006 0.0233
Echinococcus multilocularis serotonin receptor 0.0337 0.018 0.0281
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0036 0.0057
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0061 0.0027 0.0042
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.001 0.6238
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0029 0.0009 0.0014
Echinococcus granulosus glutamate receptor ionotropic kainate 0.013 0.0065 0.0102
Schistosoma mansoni alpha glucosidase 0.0021 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Loa Loa (eye worm) glutathione reductase 0.0091 0.0044 0.0044
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0254 0.0134 0.0209
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0185 0.0095 0.0095
Schistosoma mansoni hypothetical protein 0.0151 0.0077 0.012
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0003 0.0022
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0209 0.0109 0.3949
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0061 0.0027 0.0042
Onchocerca volvulus 0.0079 0.0036 0.0054
Echinococcus granulosus neuropeptide s receptor 0.0233 0.0122 0.0191
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0259 0.0136 0.0136
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.001 0.0016
Schistosoma mansoni hypothetical protein 0.0018 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0185 0.0095 0.0095
Schistosoma mansoni metabotropic glutamate receptor 0.0061 0.0027 0.0042
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.0033 0.0051
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0091 0.0044 0.1536
Echinococcus multilocularis glutamate receptor 2 0.0192 0.01 0.0156
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0021 0.0005 0.0435
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0003 0.0047
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0181 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0014 0.1343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0004 0.0413
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0025 0.0025
Echinococcus multilocularis 0.0018 0.0003 0.0004
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0039 0.0014 0.0014
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0015 0.0015
Onchocerca volvulus 0.0072 0.0033 0.0047
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0017 0.0002 0.0003
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0015 0.143
Brugia malayi hypothetical protein 0.0072 0.0033 0.0033
Leishmania major cytochrome p450-like protein 0.0034 0.0012 0.0012
Echinococcus granulosus g protein coupled receptor 0.0072 0.0033 0.0051
Plasmodium falciparum histone acetyltransferase GCN5 0.0023 0.0006 0.0371
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0132 0.0066 0.0066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.0075 0.0117
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.0054 0.0084
Brugia malayi beta-lactamase 0.0079 0.0036 0.0036
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0017 0.0002 0.0002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.007 0.0032 0.0049
Loa Loa (eye worm) hypothetical protein 0.0079 0.0036 0.0036
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.012 0.0059 0.5535
Schistosoma mansoni alpha-glucosidase 0.0083 0.0039 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.001 0.093
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0002 0.0201
Brugia malayi Pre-SET motif family protein 0.0026 0.0007 0.0007
Onchocerca volvulus 0.0022 0.0005 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0025 0.1871
Schistosoma mansoni lamin 0.0022 0.0005 0.0008
Schistosoma mansoni tyrosine kinase 0.0061 0.0027 0.0042
Schistosoma mansoni biogenic amine receptor 0.0072 0.0033 0.0051
Brugia malayi Cytochrome P450 family protein 0.0018 0.0003 0.0003
Brugia malayi MH1 domain containing protein 0.0026 0.0007 0.0007
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0025 0.0007 0.0634
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0002 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0007 0.0012
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0072 0.0033 0.0051
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0072 0.0033 0.0051
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0061 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.9212 0.5108 0.5108
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0033 0.0051
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0072 0.0033 0.0051
Schistosoma mansoni sodium/chloride dependent transporter 0.0282 0.015 0.0234
Brugia malayi Serotonin receptor 0.0072 0.0033 0.0033
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0003 0.0022
Brugia malayi MH2 domain containing protein 0.0386 0.0207 0.0207
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.001 0.001
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0185 0.0095 0.0095
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Echinococcus multilocularis vesicular acetylcholine transporter 1.1541 0.6401 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Schistosoma mansoni glutamate receptor NMDA 0.0474 0.0256 0.04
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0006 0.0277
Echinococcus granulosus importin subunit beta 1 0.0017 0.0002 0.0004
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0017 0.0002 0.0003
Echinococcus multilocularis neuropeptide Y receptor 0.0072 0.0033 0.0051
Onchocerca volvulus 0.0072 0.0033 0.0047
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.013 0.0065 0.0102
Schistosoma mansoni neuropeptide receptor 0.0072 0.0033 0.0051
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0025 0.004
Plasmodium vivax hypothetical protein, conserved 0.0185 0.0095 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0061 0.0027 0.0039
Giardia lamblia GTOR 0.0039 0.0014 0.9293
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.001 0.001
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0185 0.0095 0.0149
Echinococcus granulosus neuropeptide receptor 0.0072 0.0033 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.001 0.093
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0025 0.1871
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0025 0.255
Schistosoma mansoni tyrosine kinase 0.0061 0.0027 0.0042
Onchocerca volvulus 0.0185 0.0095 0.0146
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.001 0.001
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0039 0.0014 0.5277
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0003 0.0022
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0017 0.0002 0.0077
Trypanosoma brucei importin beta-1 subunit, putative 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0282 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.043 0.0232 0.0232
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0185 0.0095 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0027 0.0027
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0072 0.0033 0.0051
Loa Loa (eye worm) hypothetical protein 0.0221 0.0116 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0005 0.0005
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.011 0.0054 0.0084
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0868 0.0475 0.0475
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0003 0.0047
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0015 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.001 0.066
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0002
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0039 0.0014 0.0022
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0012 0.0012
Loa Loa (eye worm) cytochrome P450 0.0018 0.0003 0.0003
Trypanosoma cruzi cAMP binding protein, putative 0.0017 0.0002 0.0002
Schistosoma mansoni smad1 5 8 and 0.0026 0.0007 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.0075 0.0117
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0185 0.0095 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0006 0.0518
Trypanosoma cruzi Emopamil binding protein, putative 0.0238 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0025 0.004
Brugia malayi G-protein coupled receptor 0.0072 0.0033 0.0033
Brugia malayi Cytochrome P450 family protein 0.0034 0.0012 0.0012
Onchocerca volvulus 0.0072 0.0033 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0007 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.001 0.093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0006 0.053
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0241 0.0126 1
Echinococcus granulosus intermediate filament protein 0.0022 0.0005 0.0008
Echinococcus granulosus biogenic amine 5HT receptor 0.0072 0.0033 0.0051
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0028 0.0043
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0006 0.0288
Leishmania major cyclic nucleotide-binding protein-like protein 0.0017 0.0002 0.0002
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.043 0.0232 0.0232
Schistosoma mansoni opsin-like receptor 0.0072 0.0033 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.0054 0.0084
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0185 0.0095 0.0095
Schistosoma mansoni glutamate receptor AMPA 0.0192 0.01 0.0156
Echinococcus multilocularis g protein coupled receptor 0.0072 0.0033 0.0051
Onchocerca volvulus Vesicular acetylcholine transporter homolog 1.1541 0.6401 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0022 0.0005 0.0005
Echinococcus granulosus neuropeptide Y receptor 0.0072 0.0033 0.0051
Echinococcus granulosus serotonin transporter 0.0282 0.015 0.0234
Echinococcus multilocularis nmda type glutamate receptor 0.0576 0.0313 0.0488
Loa Loa (eye worm) hypothetical protein 0.0337 0.018 0.018
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0036 0.2755
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0017 0.0002 0.0003
Echinococcus granulosus histone acetyltransferase KAT2B 0.0025 0.0007 0.0011
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0017 0.0002 0.0002
Echinococcus granulosus 7tm_1 domain containing protein 0.0072 0.0033 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Leishmania major cytochrome p450-like protein 0.0018 0.0003 0.0003
Trypanosoma brucei importin beta-1 subunit, putative 0.0017 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0003 0.0047
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0017 0.0002 0.0003
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0028 0.0043
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0029 0.0009 0.0009
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0238 0.0125 0.0125
Leishmania major cytochrome p450-like protein 0.0018 0.0003 0.0003
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0015 0.0024
Echinococcus multilocularis fmrfamide receptor 0.0072 0.0033 0.0051
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0371 0.0199 0.0311
Echinococcus granulosus g-protein coupled receptor 0.0072 0.0033 0.0051
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.001 0.066
Loa Loa (eye worm) glutamate receptor 1 0.0192 0.01 0.01
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0007 0.0012
Onchocerca volvulus 0.0185 0.0095 0.0146
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0033 0.0051
Onchocerca volvulus 0.0072 0.0033 0.0047
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0027 0.0008 0.0218
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.0033 0.0051
Brugia malayi Pre-SET motif family protein 0.0181 0.0093 0.0093
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0238 0.0125 0.0125
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.013 0.0065 0.0102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0868 0.0475 0.0475
Toxoplasma gondii hypothetical protein 0.0185 0.0095 1
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0012 0.0012
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0003 0.0047
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.001 0.0016
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0017 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0282 0.015 0.015
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0182 0.0094 0.0094
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0039 0.0014 0.0022
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0072 0.0033 0.0051
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0072 0.0033 0.0051
Schistosoma mansoni voltage-gated potassium channel 0.0144 0.0073 0.0113
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0061 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0282 0.015 0.015
Schistosoma mansoni voltage-gated potassium channel 0.0144 0.0073 0.0113
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0017 0.0002 0.0003
Mycobacterium leprae putative cytochrome p450 0.0018 0.0003 0.0049
Loa Loa (eye worm) beta-lactamase 0.0079 0.0036 0.0036
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0072 0.0033 0.0047
Brugia malayi Dopamine receptor protein 2 0.0072 0.0033 0.0033
Echinococcus multilocularis serotonin receptor 0.0337 0.018 0.0281
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0018 0.0003 0.0003
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0185 0.0095 0.0095
Schistosoma mansoni glutamate receptor kainate 0.0192 0.01 0.0156
Schistosoma mansoni amine GPCR 0.0072 0.0033 0.0051
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0003 0.0022
Onchocerca volvulus 0.0072 0.0033 0.0047
Schistosoma mansoni alpha-1 adrenergic receptor 0.0072 0.0033 0.0051
Schistosoma mansoni lamin 0.0022 0.0005 0.0008
Echinococcus multilocularis snurportin 1 0.0182 0.0094 0.0147
Loa Loa (eye worm) hypothetical protein 1.8023 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0039 0.0014 0.0014
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0041 0.0015 0.0015
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0072 0.0033 0.0051
Brugia malayi Importin beta-1 subunit 0.0017 0.0002 0.0002
Echinococcus multilocularis dro:myosuppressin receptor 0.0072 0.0033 0.0051
Schistosoma mansoni cpg binding protein 0.0025 0.0007 0.0011
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0038 0.006
Echinococcus granulosus hypothetical protein 0.0072 0.0033 0.0051
Trypanosoma cruzi Flagellar Member 6 0.0017 0.0002 0.0002
Loa Loa (eye worm) latrophilin receptor protein 2 0.007 0.0032 0.0032
Echinococcus granulosus 7TM GPCR rhodopsin 0.0072 0.0033 0.0051
Loa Loa (eye worm) hypothetical protein 0.0041 0.0015 0.0015
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0132 0.0066 0.0103
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0025 0.0007 0.057
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0015 0.5629
Plasmodium vivax glutathione reductase, putative 0.0091 0.0044 0.4433
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.0075 0.0117
Schistosoma mansoni Smad4 0.0026 0.0007 0.0012
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.001 0.0304
Echinococcus granulosus tyrosine kinase 0.0061 0.0027 0.0042
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0238 0.0125 0.0125
Plasmodium vivax importin-beta 2, putative 0.0017 0.0002 0.001
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0003 0.0047
Loa Loa (eye worm) hypothetical protein 0.0061 0.0027 0.0027
Echinococcus granulosus snurportin 1 0.0182 0.0094 0.0147
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0003 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0003 0.0022
Toxoplasma gondii hypothetical protein 0.0185 0.0095 1
Schistosoma mansoni opsin-like receptor 0.0072 0.0033 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0017 0.0002 0.0003
Onchocerca volvulus 0.0072 0.0033 0.0047
Brugia malayi Egg laying defective protein 4 0.0017 0.0002 0.0002
Echinococcus multilocularis neuropeptide Y receptor 0.0072 0.0033 0.0051
Echinococcus granulosus glutamate receptor 2 0.0254 0.0134 0.0209
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.001 0.0016
Brugia malayi RE15519p 0.0072 0.0033 0.0033
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0241 0.0126 0.8435
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0015 0.0892
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0061 0.0027 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0033 0.0051
Echinococcus multilocularis neuropeptides capa receptor 0.0072 0.0033 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0002 0.0003
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0007 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.001 0.001
Onchocerca volvulus 0.0282 0.015 0.023
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0017 0.0002 0.0003
Schistosoma mansoni amine GPCR 0.0072 0.0033 0.0051
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0502 0.0272 1
Loa Loa (eye worm) hypothetical protein 0.0235 0.0123 0.0123
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0003 0.0047
Echinococcus granulosus hyperpolarization activated cyclic 0.0029 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0051 0.0021 0.0021
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0015 0.1408
Schistosoma mansoni neuropeptide receptor 0.0072 0.0033 0.0051
Onchocerca volvulus 0.0082 0.0038 0.0057
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0015 0.0024
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0029 0.0009 0.0014
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0029 0.0009 0.0009
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0015 0.0015
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0007 0.0012
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0015 1
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.011 0.0054 0.0084
Onchocerca volvulus 0.0072 0.0033 0.0047
Brugia malayi Cytochrome P450 family protein 0.0034 0.0012 0.0012
Leishmania major hypothetical protein, conserved 0.0079 0.0036 0.0036
Trypanosoma brucei Emopamil binding protein, putative 0.0238 0.0125 0.0125
Brugia malayi latrophilin 2 splice variant baaae 0.0151 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0061 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0061 0.0027 0.0027
Echinococcus granulosus metabotropic glutamate receptor 2 0.0061 0.0027 0.0042
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.001 0.001
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0015 0.0488
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0006 0.0006
Leishmania major protein kinase, putative 0.0017 0.0002 0.0002
Schistosoma mansoni amine GPCR 0.0072 0.0033 0.0051
Brugia malayi Glutamate receptor 1 precursor 0.0192 0.01 0.01
Giardia lamblia Histone acetyltransferase GCN5 0.0023 0.0006 0.2636
Brugia malayi neuropeptide F receptor 0.0072 0.0033 0.0033
Echinococcus multilocularis Smad4 0.0026 0.0007 0.0012
Echinococcus granulosus lamin dm0 0.0022 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0097 0.0046 0.0046
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0015 0.143
Onchocerca volvulus 0.0072 0.0033 0.0047
Echinococcus multilocularis receptor type guanylyl cyclase 0.0061 0.0027 0.0042
Brugia malayi sulfakinin receptor protein 0.0072 0.0033 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Brugia malayi Thioredoxin reductase 0.0091 0.0044 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0009 0.0825
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0007 0.0678
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0014 0 0.0042
Trypanosoma cruzi cAMP response protein 1 0.0017 0.0002 0.0002
Trichomonas vaginalis sucrase-isomaltase, putative 0.0021 0.0005 0.0435
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0702 0.0383 0.0598
Schistosoma mansoni hypothetical protein 0.007 0.0032 0.0049
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0006 0.0128
Schistosoma mansoni transient receptor potential channel 0.0063 0.0028 0.0043
Brugia malayi beta-lactamase family protein 0.0079 0.0036 0.0036
Loa Loa (eye worm) transcription factor SMAD2 0.0386 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Brugia malayi hypothetical protein 0.0072 0.0033 0.0033
Brugia malayi Metabotropic glutamate receptor precursor. 0.0061 0.0027 0.0027
Brugia malayi Serotonin receptor 0.0072 0.0033 0.0033
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0003 0.0049
Echinococcus multilocularis cpg binding protein 0.0025 0.0007 0.0011
Loa Loa (eye worm) glutamate receptor 0.0061 0.0027 0.0027
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0036 0.1271
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0039 0.0014 0.0014
Loa Loa (eye worm) norepinephrine transporter 0.0282 0.015 0.015
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0039 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0079 0.0036 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0003 0.0022
Leishmania major alpha glucosidase II subunit, putative 0.0021 0.0005 0.0005
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0036 0.2755
Treponema pallidum sodium- and chloride- dependent transporter 0.0282 0.015 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.001 0.0879
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0073 0.0034 0.0052
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0039 0.0014 0.0014
Echinococcus multilocularis lysosomal alpha glucosidase 0.0097 0.0046 0.0072
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0007 0.0012
Plasmodium falciparum glutathione reductase 0.0032 0.001 0.0879
Schistosoma mansoni sodium/chloride dependent transporter 0.0868 0.0475 0.0742
Echinococcus granulosus cpg binding protein 0.0025 0.0007 0.0011
Echinococcus multilocularis somatostatin receptor 0.0072 0.0033 0.0051
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0132 0.0066 0.0066
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0185 0.0095 0.0149
Loa Loa (eye worm) hypothetical protein 0.007 0.0032 0.0032
Echinococcus granulosus cGMP dependent protein kinase 1 0.0017 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Echinococcus granulosus nuclear factor of activated T cells 5 0.0026 0.0007 0.0011
Brugia malayi MH1 domain containing protein 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0072 0.0033 0.0047
Trypanosoma brucei protein kinase A regulatory subunit 0.0017 0.0002 0.0002
Echinococcus multilocularis neuropeptide receptor A26 0.0233 0.0122 0.0191
Brugia malayi hypothetical protein 0.0072 0.0033 0.0033
Schistosoma mansoni biogenic amine receptor 0.0072 0.0033 0.0051
Toxoplasma gondii exonuclease III APE 0.0041 0.0015 0.1475
Echinococcus granulosus biogenic amine 5HT receptor 0.0337 0.018 0.0281
Loa Loa (eye worm) thioredoxin reductase 0.0091 0.0044 0.0044
Echinococcus granulosus voltage gated potassium channel 0.0041 0.0015 0.0024
Echinococcus granulosus dnaJ subfamily B 0.034 0.0181 0.0283
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0072 0.0033 0.0051
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Brugia malayi Guanylyl cyclase protein 23 0.0061 0.0027 0.0027
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.001 0.4906
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.001 0.001
Echinococcus multilocularis orexin receptor type 2 0.0072 0.0033 0.0051
Schistosoma mansoni glutamate receptor kainate 0.0192 0.01 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0004 0.0413
Echinococcus granulosus thioredoxin glutathione reductase 0.0092 0.0044 0.0068
Leishmania major C-8 sterol isomerase-like protein 1.8023 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0034 0.0034
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0006 0.0443
Echinococcus multilocularis glutamate receptor NMDA 0.0205 0.0107 0.0166
Brugia malayi Transient-receptor-potential like protein 0.004 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0151 0.0077 0.0077
Mycobacterium tuberculosis Probable reductase 0.0209 0.0109 0.3949
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Echinococcus multilocularis hyperpolarization activated cyclic 0.0029 0.0009 0.0014
Echinococcus granulosus neuropeptide FF receptor 2 0.0072 0.0033 0.0051
Echinococcus granulosus g protein coupled receptor 0.0072 0.0033 0.0051
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0003 0.0003
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0003 0.0003
Echinococcus multilocularis G protein coupled receptor 139 0.0072 0.0033 0.0051
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0086 0.004 0.0063
Echinococcus granulosus neutral alpha glucosidase AB 0.0021 0.0005 0.0007
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0003 0.0022
Schistosoma mansoni alpha-glucosidase 0.0083 0.0039 0.0061
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0254 0.0134 0.0209
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0002 0.0088
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Echinococcus granulosus neuropeptide Y receptor 0.0072 0.0033 0.0051
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Echinococcus multilocularis TRP (transient receptor potential) channel 0.004 0.0015 0.0023
Onchocerca volvulus 0.0072 0.0033 0.0047
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0029 0.0009 0.0014
Schistosoma mansoni hypothetical protein 0.0072 0.0033 0.0051
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0025 0.0007 0.0497
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0002 0.0002
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0031 0.001 0.001
Brugia malayi Receptor family ligand binding region containing protein 0.0061 0.0027 0.0027
Schistosoma mansoni 60S ribosomal protein L21 0.0024 0.0006 0.001
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0021 0.0005 0.0344
Loa Loa (eye worm) phosphatidylinositol 3 0.0039 0.0014 0.0014
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0282 0.015 0.015
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0029 0.0009 0.0014
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0185 0.0095 0.0149
Echinococcus granulosus receptor type guanylyl cyclase 0.0061 0.0027 0.0042
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0006 0.0368
Brugia malayi hypothetical protein 0.0072 0.0033 0.0033
Echinococcus multilocularis glutamate receptor subunit protein glur 0.013 0.0065 0.0102
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.0033 0.0051
Brugia malayi Dopamine receptor protein 1 0.0072 0.0033 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0014 0.1343
Trypanosoma cruzi Emopamil binding protein, putative 0.0238 0.0125 0.0125
Echinococcus granulosus neuropeptide receptor 0.0072 0.0033 0.0051
Plasmodium falciparum thioredoxin reductase 0.0032 0.001 0.0879
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0015 0.1057
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0017 0.0002 0.0002
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0017 0.0002 0.0077
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.007 0.0032 0.0049
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0259 0.0136 0.0213
Loa Loa (eye worm) MH2 domain-containing protein 0.0386 0.0207 0.0207
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0072 0.0033 0.0051
Onchocerca volvulus 0.0206 0.0107 0.0164
Brugia malayi putative neuropeptide receptor NPR1 0.0072 0.0033 0.0033
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0185 0.0095 0.0149
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0072 0.0033 0.0051
Echinococcus multilocularis neuropeptide receptor 0.0072 0.0033 0.0051
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.012 0.0059 0.5535
Echinococcus granulosus geminin 0.0758 0.0413 0.0646
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.0054 0.0084
Echinococcus granulosus sodium and chloride dependent glycine 0.0868 0.0475 0.0742
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0132 0.0066 0.0103
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0039 0.0014 0.5277
Echinococcus granulosus smad 0.0026 0.0007 0.0012
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0017 0.0002 0.0003
Trichomonas vaginalis maltase-glucoamylase, putative 0.0021 0.0005 0.0435
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0015 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0004 0.0412
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.0075 0.0117
Plasmodium falciparum thioredoxin reductase 0.0091 0.0044 0.4433
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0003 0.0047
Mycobacterium tuberculosis Conserved protein 0.0079 0.0036 0.1271
Brugia malayi Intermediate filament tail domain containing protein 0.0022 0.0005 0.0005
Echinococcus granulosus neuropeptides capa receptor 0.0072 0.0033 0.0051
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.001 0.0967
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0072 0.0033 0.0051
Brugia malayi follicle stimulating hormone receptor 0.0352 0.0188 0.0188
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0017 0.0002 0.0077
Onchocerca volvulus 0.0072 0.0033 0.0047
Schistosoma mansoni cpg binding protein 0.0024 0.0006 0.0009
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0352 0.0188 0.0188
Schistosoma mansoni cytochrome P450 0.0018 0.0003 0.0004
Toxoplasma gondii melibiase subfamily protein 0.011 0.0054 0.5586
Schistosoma mansoni glutamate receptor AMPA 0.0192 0.01 0.0156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0015 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0005 0.0435
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Loa Loa (eye worm) TYRA-2 protein 0.0072 0.0033 0.0033
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0072 0.0033 0.0051
Brugia malayi hypothetical protein 0.0185 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Echinococcus granulosus glutamate receptor subunit protein glur 0.013 0.0065 0.0102
Brugia malayi Dopamine receptor 0.0072 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0079 0.0036 0.0036
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0017 0.0002 0.0003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.007 0.0032 0.0049
Brugia malayi hypothetical protein 0.0072 0.0033 0.0033
Echinococcus multilocularis fmrfamide receptor 0.0072 0.0033 0.0051
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0073 0.0034 0.3139
Echinococcus multilocularis transient receptor potential ion channel A 0.0078 0.0036 0.0056
Loa Loa (eye worm) hypothetical protein 0.009 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Brugia malayi acetyltransferase, GNAT family protein 0.0086 0.004 0.004
Brugia malayi larval opioid receptor 0.0072 0.0033 0.0033
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0241 0.0126 0.8435
Loa Loa (eye worm) hypothetical protein 0.004 0.0015 0.0015
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0185 0.0095 0.0149
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0021 0.0005 0.0435
Echinococcus granulosus transient receptor potential ion channel A 0.0078 0.0036 0.0056
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0148 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0061 0.0027 0.0027
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0015 0.0015
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0003 0.0047
Schistosoma mansoni hypothetical protein 0.034 0.0181 0.0283
Schistosoma mansoni hypothetical protein 0.0758 0.0413 0.0646
Brugia malayi hypothetical protein 0.0072 0.0033 0.0033
Plasmodium vivax SET domain protein, putative 0.0026 0.0007 0.0563
Echinococcus granulosus lamin 0.0022 0.0005 0.0008
Brugia malayi glutathione reductase 0.0091 0.0044 0.0044
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0003 0.0022
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0039 0.0014 0.0014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0036 0.0057
Echinococcus granulosus atrial natriuretic peptide receptor 0.0061 0.0027 0.0042
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0003 0.0047
Onchocerca volvulus 0.0072 0.0033 0.0047
Brugia malayi Glycosyl hydrolases family 31 protein 0.0021 0.0005 0.0005
Schistosoma mansoni intermediate filament proteins 0.0022 0.0005 0.0008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0015 0.1408
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0007 0.0012
Brugia malayi Cyclic-nucleotide gated cation channel 0.0029 0.0009 0.0009
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0868 0.0475 0.0475
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0003 0.0022
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0006 0.0277
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0017 0.0002 0.0003
Brugia malayi ORL1-like opioid receptor 0.0072 0.0033 0.0033
Onchocerca volvulus 0.0185 0.0095 0.0146
Echinococcus multilocularis allatostatin A receptor 0.0072 0.0033 0.0051
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0017 0.0002 0.0077
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0185 0.0095 0.0149
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0017 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0004 0.0412
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.0007 0.0012
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0017 0.0002 0.0002
Schistosoma mansoni smad1 5 8 and 0.0026 0.0007 0.0012
Schistosoma mansoni cpg binding protein 0.0025 0.0007 0.0011
Schistosoma mansoni protein kinase 0.0061 0.0027 0.0042
Onchocerca volvulus 0.0022 0.0005 0.0004
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0016 0.0002 0.0002
Brugia malayi Glycosyl hydrolases family 31 protein 0.0097 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0003 0.0022
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0029 0.0009 0.0837
Onchocerca volvulus 0.0072 0.0033 0.0047
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0036 0.3404
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0033 0.0051
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0036 0.0036
Trypanosoma brucei C-8 sterol isomerase, putative 1.8023 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0072 0.0033 0.0051
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0254 0.0134 0.0209
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0029 0.0009 0.0014
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0021 0.0005 0.1594
Schistosoma mansoni transient receptor potential channel 4 0.009 0.0043 0.0067
Brugia malayi beta-lactamase family protein 0.0079 0.0036 0.0036
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0072 0.0033 0.0033
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.001 0.0879
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0017 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Brugia malayi GnHR receptor homolog 0.0072 0.0033 0.0033
Onchocerca volvulus 0.0061 0.0027 0.0039
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0254 0.0134 0.0209
Schistosoma mansoni hypothetical protein 0.007 0.0032 0.0049
Onchocerca volvulus 0.0026 0.0007 0.0008
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0021 0.0005 0.0005
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0012 0.0012
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0185 0.0095 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.0075 0.0117
Echinococcus granulosus alpha 1A adrenergic receptor 0.0072 0.0033 0.0051
Brugia malayi MH2 domain containing protein 0.0026 0.0007 0.0007
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0017 0.0002 0.0077
Entamoeba histolytica hypothetical protein 0.0061 0.0027 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0004 0.0413
Schistosoma mansoni neuropeptide F-like receptor 0.0072 0.0033 0.0051
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.0033 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.001 0.001
Brugia malayi Cytochrome P450 family protein 0.0018 0.0003 0.0003
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0072 0.0033 0.0033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0052 0.0021 0.0033
Echinococcus multilocularis sodium and chloride dependent glycine 0.0868 0.0475 0.0742
Echinococcus multilocularis transient receptor potential gamma protein 0.009 0.0043 0.0067
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0232 0.0121 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.001 0.001
Echinococcus granulosus GPCR family 2 0.007 0.0032 0.0049
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0072 0.0033 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0036 0.3404
Loa Loa (eye worm) neuropeptide F receptor 0.0072 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0115 0.0057 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0036 0.0036
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0072 0.0033 0.0051
Brugia malayi Melatonin receptor type 1A 0.0072 0.0033 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0003 0.0022
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0036 0.0057
Schistosoma mansoni vesicular acetylcholine transporter 1.1541 0.6401 1
Echinococcus multilocularis g-protein coupled receptor 0.0072 0.0033 0.0051
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.001 0.001
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0025 0.0007 0.057
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 1.1541 0.6401 0.6401
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.013 0.0065 0.0102
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0002 0.0003
Leishmania major trypanothione reductase 0.0091 0.0044 0.0044
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0254 0.0134 0.0209
Toxoplasma gondii ABC1 family protein 0.0079 0.0036 0.3719
Echinococcus granulosus cGMP dependent protein kinase 1 0.0017 0.0002 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0003 0.0022
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0072 0.0033 0.0051
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0005 0.0435
Schistosoma mansoni glutamate receptor NMDA 0.0459 0.0247 0.0387
Trypanosoma brucei trypanothione reductase 0.0091 0.0044 0.0044
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0015 0.0024
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0017 0.0002 0.0003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0036 0.1271
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0038 0.006
Echinococcus granulosus nmda type glutamate receptor 0.0266 0.0141 0.022
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.0033 0.0051
Leishmania major protein kinase, putative 0.0017 0.0002 0.0002
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0017 0.0002 0.0003
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0185 0.0095 0.0149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0033 0.0051
Trypanosoma cruzi cAMP response protein 1, putative 0.0017 0.0002 0.0002
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0016 0.0001 0.0002
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0003 0.0047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0015 0.0015
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0015 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0006 0.0518
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0003 0.014
Onchocerca volvulus 0.0072 0.0033 0.0047
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Echinococcus multilocularis neuropeptide s receptor 0.0233 0.0122 0.0191
Leishmania major regulatory subunit of protein kinase a-like protein 0.0017 0.0002 0.0002
Schistosoma mansoni neuropeptide receptor 0.0072 0.0033 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0005 0.0435
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0003 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0004 0.0413
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0003
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0073 0.0034 0.0052
Loa Loa (eye worm) glutamate receptor 2 0.0192 0.01 0.01
Echinococcus granulosus hyperpolarization activated cyclic 0.0029 0.0009 0.0014
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0072 0.0033 0.0051
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0036 0.367
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0012 0.0012
Schistosoma mansoni histamine h1 receptor 0.0072 0.0033 0.0051
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.001 0.0879
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0209 0.0109 0.3949
Loa Loa (eye worm) hypothetical protein 0.0079 0.0036 0.0036
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0006 0.0443
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0029 0.0009 0.0014
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0017 0.0002 0.0003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.0033 0.0051
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0003 0.0047
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.007 0.0032 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0033 0.0051
Echinococcus multilocularis Glycoside hydrolase, family 27 0.011 0.0054 0.0084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Brugia malayi hypothetical protein 0.0061 0.0027 0.0027
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0029 0.0009 0.0014
Echinococcus multilocularis expressed conserved protein 0.0017 0.0002 0.0003
Echinococcus granulosus glutamate NMDA receptor subunit 0.0474 0.0256 0.04
Plasmodium falciparum transporter, putative 0.0185 0.0095 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0185 0.0095 0.0149
Brugia malayi neuropeptide F receptor 0.0072 0.0033 0.0033
Echinococcus multilocularis g protein coupled receptor 0.0072 0.0033 0.0051
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0029 0.0009 0.0014
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0039 0.0014 0.0014
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0038 0.006
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.001 0.0949
Echinococcus granulosus nmda type glutamate receptor 0.0576 0.0313 0.0488
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0003 0.0047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.001 0.001
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0017 0.0002 0.0003
Treponema pallidum NADH oxidase 0.0032 0.001 0.0556
Trichomonas vaginalis importin beta-1, putative 0.0014 0 0.0042
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Schistosoma mansoni metabotropic glutamate receptor 0.0061 0.0027 0.0042
Schistosoma mansoni sodium/chloride dependent transporter 0.0868 0.0475 0.0742
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0072 0.0033 0.0051
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0072 0.0033 0.0033
Echinococcus multilocularis glutamate receptor 2 0.0123 0.0061 0.0096
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Echinococcus multilocularis glutamate receptor 2 0.0254 0.0134 0.0209
Loa Loa (eye worm) nuclear factor I 0.0015 0.0001 0.0001
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0029 0.0009 0.0014
Echinococcus multilocularis NMDA receptor 0.013 0.0065 0.0102
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0868 0.0475 0.0475
Loa Loa (eye worm) G-protein coupled receptor 0.0072 0.0033 0.0033
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0072 0.0033 0.0051
Schistosoma mansoni myosin xvIII 0.0072 0.0033 0.0051
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0017 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0061 0.0027 0.0027
Trichomonas vaginalis esterase, putative 0.0079 0.0036 0.3404
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0006 0.0277
Schistosoma mansoni growth hormone secretagogue receptor 0.0072 0.0033 0.0051
Schistosoma mansoni sodium-dependent amino acid transporter 0.0185 0.0095 0.0149
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0036 0.1271
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0241 0.0126 1
Loa Loa (eye worm) intermediate filament protein 0.0022 0.0005 0.0005
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Schistosoma mansoni opsin-like receptor 0.0072 0.0033 0.0051
Mycobacterium ulcerans beta-lactamase 0.0079 0.0036 0.2755
Brugia malayi G protein-coupled receptor F59B2.13 0.0072 0.0033 0.0033
Brugia malayi N-terminal motif family protein 0.0017 0.0002 0.0002
Brugia malayi cytochrome P450 0.0018 0.0003 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.0232 0.0121 0.4429
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0036 0.287
Schistosoma mansoni neuropeptide f receptor 76f 0.0072 0.0033 0.0051
Trypanosoma cruzi protein kinase A regulatory subunit 0.0017 0.0002 0.0002
Plasmodium falciparum glutathione reductase 0.0091 0.0044 0.4433
Schistosoma mansoni hypothetical protein 0.0072 0.0033 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.001 0.093
Loa Loa (eye worm) neuropeptide F receptor 0.0072 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Schistosoma mansoni adenoreceptor 0.0072 0.0033 0.0051
Echinococcus granulosus histone acetyltransferase KAT2B 0.0083 0.0039 0.0061
Mycobacterium ulcerans transmembrane transport protein 0.0027 0.0008 0.0473
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0086 0.004 0.0063
Trypanosoma brucei cAMP response protein 1, putative 0.0017 0.0002 0.0002
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0002 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0033 0.0051
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0254 0.0134 0.0209
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0036 0.1271
Brugia malayi Receptor family ligand binding region containing protein 0.0061 0.0027 0.0027
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0014 0 0.0042
Onchocerca volvulus 0.0238 0.0125 0.0192
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0209 0.0109 0.3949
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0007 0.0007
Echinococcus granulosus g protein coupled receptor 0.0072 0.0033 0.0051
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0017 0.0002 0.0077
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0005 0.0435
Schistosoma mansoni hypothetical protein 0.0182 0.0094 0.0147
Brugia malayi Melibiase family protein 0.0073 0.0034 0.0034
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0061 0.0027 0.0042
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0021 0.0005 0.1594
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0072 0.0033 0.0033
Brugia malayi RNA, U transporter 1 0.0049 0.002 0.002
Echinococcus granulosus orexin receptor type 2 0.0072 0.0033 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0011 0.1048
Loa Loa (eye worm) solute carrier family 6 member 4 0.0282 0.015 0.015
Brugia malayi hypothetical protein 0.0072 0.0033 0.0033
Leishmania major hypothetical protein, unknown function 0.0017 0.0002 0.0002
Loa Loa (eye worm) acetyltransferase 0.0086 0.004 0.004
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Mycobacterium tuberculosis Conserved protein 0.0079 0.0036 0.1271
Mycobacterium tuberculosis Probable dehydrogenase 0.0209 0.0109 0.3949
Schistosoma mansoni glutamate receptor kainate 0.0192 0.01 0.0156
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0025 0.1871
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.0075 0.0117
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0061 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0259 0.0136 0.0136
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0003 0.0047
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0209 0.0109 0.8917
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0033 0.0051
Echinococcus granulosus lysosomal alpha glucosidase 0.0097 0.0046 0.0072
Schistosoma mansoni importin beta-1 0.0017 0.0002 0.0004
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0028 0.0043
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0003 0.0003
Trypanosoma cruzi target of rapamycin kinase 3 0.0031 0.001 0.001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.001 0.066
Echinococcus multilocularis voltage gated potassium channel 0.0041 0.0015 0.0024
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0006 0.0368
Trichomonas vaginalis set domain proteins, putative 0.0206 0.0107 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0082 0.0038 0.0038
Echinococcus granulosus metabotropic glutamate receptor 5 0.0061 0.0027 0.0042
Schistosoma mansoni biogenic amine (5HT) receptor 0.0337 0.018 0.0281
Schistosoma mansoni smad1 5 8 and 0.0026 0.0007 0.0012
Brugia malayi G-protein coupled receptor 0.0072 0.0033 0.0033
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0221 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0072 0.0033 0.0033
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0185 0.0095 0.0149
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Brugia malayi MH1 domain containing protein 0.0026 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0079 0.0036 0.0036
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0209 0.0109 0.3949

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -4.9 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 0.42 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 0.69 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 16 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 35 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 100 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 10.34 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -3 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 16 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 35 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 100 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.05 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.88992 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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