Detailed information for compound 606574

Basic information

Technical information
  • TDR Targets ID: 606574
  • Name: 2-hydroxy-7-methoxy-2-(1,1,2,2,2-pentafluoroe thyl)chroman-4-one
  • MW: 312.189 | Formula: C12H9F5O4
  • H donors: 1 H acceptors: 2 LogP: 2.43 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)OC(CC2=O)(O)C(C(F)(F)F)(F)F
  • InChi: 1S/C12H9F5O4/c1-20-6-2-3-7-8(18)5-10(19,21-9(7)4-6)11(13,14)12(15,16)17/h2-4,19H,5H2,1H3
  • InChiKey: NQJASZMLBMBHRG-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-hydroxy-7-methoxy-2-(1,1,2,2,2-pentafluoroethyl)-4-chromanone
  • STOCK2S-53587

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum protein kinase 7 Starlite/ChEMBL No references
Leishmania mexicana glucose transporter, lmgt2 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 6 Starlite/ChEMBL No references
Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 1 Starlite/ChEMBL No references
Plasmodium falciparum mitogen-activated protein kinase 2 Starlite/ChEMBL No references
Plasmodium falciparum lysine--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum hexose transporter Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Proline--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Calcium-dependent protein kinase 4 Starlite/ChEMBL No references
Plasmodium falciparum calcium-dependent protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Sugar transporter family protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 3, putative Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania braziliensis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Toxoplasma gondii protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii cdk-related protein kinase 6-related Get druggable targets OG5_155179 All targets in OG5_155179
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Babesia bovis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium falciparum protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani glucose transporter 1 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania infantum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania donovani glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii putative sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium vivax lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum protein kinase, PfPK7 homolog, putative Get druggable targets OG5_145294 All targets in OG5_145294
Loa Loa (eye worm) sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium hominis aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Theileria parva prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei glucose transporter 2A Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania donovani glucose transporter 3, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium knowlesi hexose transporter, putative Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium vivax hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium berghei proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum IPR000924,Glutamyl-tRNA synthetase, class Ic;IPR001412,Aminoacyl-tRNA synthetase, class I,domain-containing Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Leishmania infantum glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum expressed protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Toxoplasma gondii lysine-tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium yoelii lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 1, putative Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K07191 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Giardia lamblia Prolyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Brugia malayi Bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis mitogen-activated protein kinase, putative Get druggable targets OG5_138034 All targets in OG5_138034
Echinococcus granulosus lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei gambiense glucose transporter,glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum IPR005828,General substrate transporter,domain-containing Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum ko:K07299 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Giardia lamblia Lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi protein kinase 7, putative Get druggable targets OG5_145294 All targets in OG5_145294
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum ko:K04567 lysyl-tRNA synthetase, class II, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum CMGC kinase, MAPK family, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium falciparum mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 4, putative Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium parvum proline-tRNA synthetase; class II aaRS (ybak RNA binding domain plus tRNA synthetase) Get druggable targets OG5_127154 All targets in OG5_127154
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania braziliensis lmgt2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Chlamydia trachomatis lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium parvum mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Glucose transporter 1A, related Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium parvum lysyl-tRNA synthetase (NOB+tRNA synthetase) Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K01881 prolyl-tRNA synthetase [EC6.1.1.15], putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis solute carrier family 2, facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis Kars protein Get druggable targets OG5_126972 All targets in OG5_126972
Theileria parva mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma brucei glucose transporter 1E Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium yoelii Ser/Thr protein kinase Get druggable targets OG5_145294 All targets in OG5_145294
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense glucose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium yoelii mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Mycobacterium leprae Probable prolyl tRNA synthetase ProS Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Toxoplasma gondii facilitative glucose transporter GT1 Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania mexicana protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.2 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 527 aa 25.6 %
Toxoplasma gondii calcium-dependent protein kinase CDPK9 Calcium-dependent protein kinase 4   528 aa 500 aa 34.2 %
Leishmania infantum protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Toxoplasma gondii calcium-dependent protein kinase CDPK6 Calcium-dependent protein kinase 4   528 aa 453 aa 34.0 %
Neospora caninum Calcium-dependent protein kinase, related Calcium-dependent protein kinase 4   528 aa 516 aa 35.5 %
Leishmania braziliensis protein kinase, putative Calcium-dependent protein kinase 4   528 aa 490 aa 27.3 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 522 aa 25.5 %
Cryptosporidium hominis calmodulin-domain protein kinase 2 Calcium-dependent protein kinase 4   528 aa 468 aa 36.1 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 29.0 %
Babesia bovis mitogen-activated protein kinase, putative Calcium-dependent protein kinase 4   528 aa 427 aa 23.4 %
Cryptosporidium hominis hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase 7 343 aa 310 aa 25.2 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Calcium-dependent protein kinase 4   528 aa 468 aa 35.9 %
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Leishmania donovani protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Trypanosoma brucei gambiense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Trypanosoma brucei glucose transporter, putative hexose transporter 504 aa 426 aa 22.3 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 28.8 %
Neospora caninum CAM kinase, CDPK family, putative Calcium-dependent protein kinase 4   528 aa 463 aa 32.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 protein kinase 6 305 aa 338 aa 27.2 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 499 aa 29.3 %
Cryptosporidium parvum hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Entamoeba histolytica protein kinase, putative Calcium-dependent protein kinase 4   528 aa 429 aa 26.3 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 509 aa 25.5 %
Babesia bovis calcium-dependent protein kinase, putative Calcium-dependent protein kinase 4   528 aa 450 aa 30.2 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands Calcium-dependent protein kinase 4   528 aa 501 aa 28.9 %
Theileria parva protein kinase, putative Calcium-dependent protein kinase 4   528 aa 507 aa 27.4 %
Leishmania major protein kinase, putative Calcium-dependent protein kinase 4   528 aa 488 aa 27.5 %
Cryptosporidium hominis calcium-dependent protein kinase Calcium-dependent protein kinase 4   528 aa 502 aa 29.7 %
Trypanosoma brucei protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Theileria parva calmodulin-domain protein kinase, putative Calcium-dependent protein kinase 4   528 aa 454 aa 31.9 %
Giardia lamblia Kinase, NEK Calcium-dependent protein kinase 4   528 aa 509 aa 19.8 %
Trypanosoma brucei glucose transporter, putative solute carrier family 2 (facilitated glucose transporter), member 1 492 aa 395 aa 23.5 %
Toxoplasma gondii calcium-dependent protein kinase CDPK2 Calcium-dependent protein kinase 4   528 aa 480 aa 36.9 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 517 aa 27.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0124 0.079
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.004 0.0419 0.0795
Brugia malayi hypothetical protein 0.0034 0.0332 0.053
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0391 0.0807
Mycobacterium tuberculosis Conserved protein 0.0079 0.1025 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0047 0.0044
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0411 0.2207
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0053 0.005
Echinococcus multilocularis solute carrier family 22 0.0018 0.0084 0.0038
Leishmania major cathepsin L-like protease 0.0019 0.0097 0.0082
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0661 0.1058
Echinococcus granulosus mitogen activated protein kinase 0.0115 0.1563 0.1561
Giardia lamblia GTOR 0.0019 0.011 0.0174
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0661 0.0658
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0221 0.0175
Plasmodium falciparum calcium-dependent protein kinase 5 0.004 0.0419 0.0423
Schistosoma mansoni lamin 0.0033 0.0311 0.0308
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0356 0.228
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0084 0.0038
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.011 0.0174
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Leishmania major DNA damage repair protein, putative 0.002 0.0124 0.0264
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0487 0.0509
Giardia lamblia PHD finger protein 15 0.0029 0.0262 0.12
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0097 0.0199
Brugia malayi Cathepsin L-like precursor 0.0019 0.0097 0.015
Loa Loa (eye worm) cysteine protease 0.0019 0.0097 0.0155
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0661 0.0658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Plasmodium falciparum calcium-dependent protein kinase 2 0.004 0.0419 0.0423
Loa Loa (eye worm) hypothetical protein 0.0116 0.1587 0.2553
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0097 0.0199
Trichomonas vaginalis beta lactamase domain, putative 0.0079 0.1025 0.2115
Echinococcus multilocularis zinc finger protein 0.0044 0.0479 0.0434
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.1025 0.2115
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0812 0.5193
Echinococcus granulosus sodium:glucose cotransporter 0.0046 0.052 0.0517
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0079 0.1025 0.0983
Brugia malayi intermediate filament protein 0.0033 0.0311 0.0495
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0356 0.0983
Onchocerca volvulus 0.0046 0.052 0.1437
Echinococcus multilocularis solute carrier family 5 0.0046 0.052 0.0475
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0043 0.0473 0.2631
Echinococcus granulosus pyruvate kinase 0.0036 0.0356 0.0354
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0812 0.4919
Trypanosoma brucei protein kinase, putative 0.0115 0.1563 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Echinococcus granulosus dna polymerase kappa 0.0065 0.0812 0.0809
Plasmodium falciparum protein kinase 6 0.0537 0.8 1
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0097 0.015
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0079 0.1025 0.6559
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0079 0.1025 0.1645
Brugia malayi Pre-SET motif family protein 0.0032 0.03 0.0477
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0104 0.0058
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Onchocerca volvulus 0.0018 0.0084 0.0226
Echinococcus granulosus high affinity choline transporter 1 0.042 0.6217 0.6216
Onchocerca volvulus 0.0018 0.0084 0.0226
Brugia malayi Bromodomain containing protein 0.0082 0.1065 0.1708
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0043 0.0473 0.0429
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0411 0.2627
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0104 0.0168
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.1739 0.3301
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0005
Onchocerca volvulus Huntingtin homolog 0.0148 0.2071 0.5749
Echinococcus granulosus lamin 0.0033 0.0311 0.0308
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0084 0.0138
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0097 0.026
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0437 0.0435
Echinococcus granulosus solute carrier family 5 0.0046 0.052 0.0517
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0079 0.1025 0.6559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Entamoeba histolytica metallo-beta-lactamase family protein 0.0079 0.1025 1
Trypanosoma cruzi ISWI complex protein 0.0033 0.0313 0.1548
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0617 0.0673
Entamoeba histolytica hypothetical protein 0.0028 0.0243 0.2352
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Loa Loa (eye worm) hypothetical protein 0.0151 0.2123 0.3416
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0891 0.57
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0891 0.57
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0356 0.0311
Onchocerca volvulus 0.0018 0.0084 0.0226
Entamoeba histolytica type A flavoprotein, putative 0.0079 0.1025 1
Brugia malayi PHD-finger family protein 0.0029 0.0262 0.0417
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0391 0.3798
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0079 0.1025 0.1649
Loa Loa (eye worm) MBCTL1 0.0116 0.1587 0.2553
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0502 0.3212
Echinococcus multilocularis cysteine protease 0.0019 0.0097 0.005
Plasmodium vivax CDK-related protein kinase 6, putative 0.0537 0.8 1
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0356 0.0677
Trypanosoma cruzi glyoxalase II 0.0079 0.1025 0.6362
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Onchocerca volvulus 0.0018 0.0084 0.0226
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.013 0.179 0.1787
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0221 0.0351
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0262 0.0216
Leishmania major pyruvate kinase 0.0036 0.0356 0.1839
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0104 0.0163
Echinococcus granulosus fetal alzheimer antigen falz 0.005 0.0576 0.0573
Brugia malayi PHD-finger family protein 0.0055 0.0653 0.1047
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0124 0.0264
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.004 0.0419 0.2678
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0824 0.7865
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0812 0.1644
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0411 0.0847
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0097 0.0199
Schistosoma mansoni myelin transcription factor 1 myt1 0.0116 0.1587 0.1585
Brugia malayi polk-prov protein 0.002 0.0124 0.0194
Echinococcus multilocularis pyruvate kinase 0.0018 0.0092 0.0046
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0445 0.0442
Entamoeba histolytica type A flavoprotein, putative 0.0079 0.1025 1
Leishmania major DNA polymerase kappa, putative 0.0065 0.0812 0.4919
Toxoplasma gondii sugar transporter ST2 0.0018 0.0084 0.016
Schistosoma mansoni hypothetical protein 0.0079 0.1025 0.1023
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0604 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.1025 0.2115
Giardia lamblia DNA damage repair protein 0.002 0.0124 0.0264
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0079 0.1025 0.0983
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.0419 0.0416
Leishmania major protein kinase, putative 0.004 0.0419 0.226
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.011 0.0174
Schistosoma mansoni hypothetical protein 0.0019 0.0104 0.0101
Schistosoma mansoni sugar transporter 0.0018 0.0084 0.0081
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0617 0.3601
Schistosoma mansoni terminal deoxycytidyl transferase 0.0065 0.0812 0.0809
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.011 0.0107
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0005
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1576 0.2535
Plasmodium vivax vivapain-2 0.0019 0.0097 0.0015
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.0124 0.0234
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.011 0.0107
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0943 0.094
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0391 0.0628
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.011 0.0064
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0356 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0812 0.5193
Schistosoma mansoni glutaminase 0.033 0.4849 0.4848
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0262 0.0224
Loa Loa (eye worm) hypothetical protein 0.0079 0.1025 0.1649
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0411 0.2627
Schistosoma mansoni microtubule-associated protein tau 0.0668 1 1
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0079 0.1025 0.6362
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.011 0.0172
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0487 0.0924
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0411 0.6086 0.6085
Schistosoma mansoni jumonji domain containing protein 0.0076 0.098 0.0977
Schistosoma mansoni ap endonuclease 0.0043 0.0473 0.0471
Trichomonas vaginalis DNA polymerase eta, putative 0.0065 0.0812 0.1674
Onchocerca volvulus 0.0032 0.03 0.0825
Brugia malayi Pre-SET motif family protein 0.0218 0.3141 0.505
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0079 0.1025 0.6362
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.0943 0.9122
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0891 0.5454
Entamoeba histolytica protein kinase, putative 0.004 0.0419 0.4066
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0943 0.1944
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0617 0.0673
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0243 0.0467
Entamoeba histolytica cysteine protease, putative 0.0019 0.0097 0.0914
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0003 0.0006
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0661 0.133
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0079 0.1025 0.6362
Loa Loa (eye worm) hypothetical protein 0.004 0.0419 0.0674
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0097 0.0199
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Onchocerca volvulus 0.003 0.0272 0.0747
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0084 0.016
Onchocerca volvulus 0.0079 0.1025 0.2843
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0092 0.001
Mycobacterium ulcerans beta lactamase-like protein 0.0079 0.1025 0.2086
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0079 0.1025 0.1023
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0046 0.052 0.0987
Loa Loa (eye worm) hypothetical protein 0.0029 0.0262 0.0421
Onchocerca volvulus 0.0018 0.0084 0.0226
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0097 0.0155
Loa Loa (eye worm) sugar transporter 0.0018 0.0084 0.0136
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0079 0.1025 0.1649
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0243 0.0201
Schistosoma mansoni bromodomain containing protein 0.0137 0.1906 0.1904
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Onchocerca volvulus 0.0019 0.0097 0.026
Entamoeba histolytica hypothetical protein 0.0043 0.0476 0.4631
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.004 0.0419 0.0674
Entamoeba histolytica metallo-beta-lactamase family protein 0.0079 0.1025 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.011 0.0704
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0077 0.0987 0.0984
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0812 0.5193
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.0124 0.0049
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0091 0.0088
Leishmania major metallo-beta-lactamase family-like protein 0.0079 0.1025 0.6362
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0079 0.1025 0.6362
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.004 0.0419 0.0423
Plasmodium falciparum hexose transporter 0.0126 0.1739 0.209
Schistosoma mansoni cpg binding protein 0.003 0.0272 0.0269
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0124 0.0264
Plasmodium vivax vivapain-2 0.0019 0.0097 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Trichomonas vaginalis beta lactamase domain, putative 0.0079 0.1025 0.2115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Echinococcus granulosus mitogen activated protein kinase 3 0.0115 0.1563 0.1561
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.011 0.0064
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.011 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0065 0.0812 0.1306
Echinococcus multilocularis peregrin 0.0034 0.0339 0.0294
Leishmania major metallo-beta-lactamase family protein-like protein 0.0079 0.1025 0.6362
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.1563 0.3224
Schistosoma mansoni zinc finger protein 0.0033 0.0313 0.031
Loa Loa (eye worm) hypothetical protein 0.005 0.0582 0.0936
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0174 0.0128
Loa Loa (eye worm) fibroinase 0.0019 0.0097 0.0155
Schistosoma mansoni zinc phosphodiesterase 0.0079 0.1025 0.1023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0857 0.0854
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0221 0.0218
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0243 0.0765
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0079 0.1025 0.1189
Echinococcus multilocularis zinc phosphodiesterase 0.0079 0.1025 0.0983
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0053 0.0007
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0473 0.0492
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.03 0.0254
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0445 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0084 0.0174
Schistosoma mansoni hypothetical protein 0.0043 0.0476 0.0474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0097 0.0199
Entamoeba histolytica hypothetical protein 0.0043 0.0476 0.4631
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0079 0.1025 0.0983
Leishmania major hypothetical protein, conserved 0.0033 0.0313 0.1548
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0104 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0812 0.5193
Loa Loa (eye worm) hypothetical protein 0.0093 0.1233 0.1983
Trichomonas vaginalis beta lactamase domain, putative 0.0079 0.1025 0.2115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.03 0.0297
Toxoplasma gondii protein kinase, putative 0.0358 0.5268 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1739 0.17
Echinococcus granulosus solute carrier family 22 0.0018 0.0084 0.0081
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0732 0.1173
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0111 0.0178
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0356 0.0573
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0005
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0367 0.0321
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0115 0.1563 1
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1739 0.3586
Leishmania major pyruvate kinase 0.0036 0.0356 0.1839
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0502 0.3212
Echinococcus multilocularis pyruvate kinase 0.0018 0.0092 0.0046
Brugia malayi Sugar transporter family protein 0.0018 0.0084 0.0131
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0473 0.0976
Leishmania major cathepsin L-like protease 0.0071 0.0891 0.5454
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0487 0.2722
Brugia malayi metallo-beta-lactamase superfamily protein 0.0079 0.1025 0.1645
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.008 0.0124
Loa Loa (eye worm) glutaminase 2 0.033 0.4849 0.78
Onchocerca volvulus 0.0018 0.0084 0.0226
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0487 0.3115
Loa Loa (eye worm) hypothetical protein 0.0041 0.0441 0.071
Onchocerca volvulus Putative hydrolase PNKD 0.0079 0.1025 0.2843
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0891 0.57
Entamoeba histolytica hypothetical protein 0.0027 0.0221 0.2131
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0411 0.2627
Echinococcus multilocularis dna polymerase eta 0.0065 0.0812 0.0769
Loa Loa (eye worm) hypothetical protein 0.0019 0.0104 0.0168
Trichomonas vaginalis beta lactamase domain, putative 0.0079 0.1025 0.2115
Loa Loa (eye worm) hypothetical protein 0.0148 0.2071 0.3331
Schistosoma mansoni sodium/solute symporter 0.0046 0.052 0.0517
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0419 0.0863
Echinococcus multilocularis lamin dm0 0.0033 0.0311 0.0265
Brugia malayi Inositol-1 0.0074 0.0943 0.1512
Brugia malayi hypothetical protein 0.0043 0.0476 0.0762
Plasmodium falciparum protein kinase 7 0.0358 0.5268 0.6549
Echinococcus multilocularis cpg binding protein 0.0036 0.036 0.0315
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.011 0.0704
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0617 0.3947
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0084 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.011 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Toxoplasma gondii sugar transporter ST1 0.0018 0.0084 0.016
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0079 0.1025 0.6362
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.071 0.1433
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0084 0.0174
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0043 0.0473 0.3029
Plasmodium falciparum calcium-dependent protein kinase 1 0.004 0.0419 0.0423
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0661 0.3895
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0812 0.5193
Plasmodium falciparum calcium-dependent protein kinase 4 0.004 0.0419 0.0423
Brugia malayi glutaminase DH11.1 0.033 0.4849 0.7799
Echinococcus multilocularis high affinity choline transporter 1 0.042 0.6217 0.6199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.203 0.2027
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.1739 0.17
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0065 0.0812 0.7731
Echinococcus granulosus pyruvate kinase 0.0036 0.0356 0.0354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Brugia malayi MH2 domain containing protein 0.0116 0.1576 0.2531
Echinococcus granulosus General substrate transporter 0.0108 0.1468 0.1466
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Giardia lamblia Pyruvate kinase 0.0036 0.0356 0.1839
Onchocerca volvulus 0.0018 0.0084 0.0226
Echinococcus granulosus SAM and MBT domain containing protein 0.0102 0.1372 0.1369
Loa Loa (eye worm) hypothetical protein 0.0023 0.0164 0.0264
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0243 0.1075
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0476 0.0474
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0243 0.024
Echinococcus granulosus sodium:glucose cotransporter 2 0.0046 0.052 0.0517
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0115 0.1563 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0043 0.0473 0.0762
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0356 0.0573
Trypanosoma brucei unspecified product 0.0045 0.0502 0.3212
Mycobacterium leprae conserved hypothetical protein 0.0079 0.1025 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0661 0.0617
Loa Loa (eye worm) hypothetical protein 0.0065 0.0812 0.1306
Onchocerca volvulus Putative transporter 0.0018 0.0084 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0097 0.0199
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Mycobacterium ulcerans glyoxalase II, GloB 0.0079 0.1025 0.2086
Brugia malayi major facilitator superfamily protein 0.0018 0.0084 0.0131
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0411 0.2207
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0097 0.0015
Loa Loa (eye worm) hypothetical protein 0.0082 0.1067 0.1716
Brugia malayi mbt repeat family protein 0.0102 0.1372 0.2202
Chlamydia trachomatis pyruvate kinase 0.0036 0.0356 0.3361
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.071 0.1433
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0046 0.052 0.0475
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0502 0.3212
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0243 0.024
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0065 0.0812 0.1674
Onchocerca volvulus 0.0248 0.3599 1
Trichomonas vaginalis glutaminase, putative 0.033 0.4849 1
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0124 0.0121
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Brugia malayi major facilitator superfamily protein 0.0018 0.0084 0.0131
Echinococcus multilocularis General substrate transporter 0.0108 0.1468 0.1428
Schistosoma mansoni cpg binding protein 0.0036 0.036 0.0357
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Loa Loa (eye worm) hypothetical protein 0.0015 0.0049 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0891 0.57
Schistosoma mansoni sugar transporter 0.0018 0.0084 0.0081
Plasmodium falciparum cytosolic glyoxalase II 0.0079 0.1025 0.1189
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0097 0.0082
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0043 0.0473 0.2631
Onchocerca volvulus 0.0018 0.0084 0.0226
Onchocerca volvulus 0.0018 0.0084 0.0226
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0243 0.0387
Echinococcus granulosus dna polymerase eta 0.0065 0.0812 0.0809
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0411 0.0847
Schistosoma mansoni hypothetical protein 0.0079 0.1025 0.1023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0891 0.57
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0891 0.57
Brugia malayi CXXC zinc finger family protein 0.003 0.0272 0.0432
Schistosoma mansoni hypothetical protein 0.0024 0.0174 0.0171
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0371 0.0368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Schistosoma mansoni hypothetical protein 0.0029 0.0262 0.0259
Mycobacterium tuberculosis Conserved hypothetical protein 0.0065 0.0812 0.7731
Trichomonas vaginalis A-type flavoprotein 0.0079 0.1025 0.2115
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0812 0.5193
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0043 0.0473 0.2631
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.004 0.0419 0.0423
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0356 0.228
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0097 0.0914
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.203 0.2027
Echinococcus multilocularis cysteine protease 0.0019 0.0097 0.005
Loa Loa (eye worm) sugar transporter 0.0126 0.1739 0.2797
Brugia malayi mbt repeat family protein 0.0102 0.1372 0.2202
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0812 0.4919
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0079 0.1025 0.1946
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0079 0.1025 0.1946
Mycobacterium leprae Beta-lactamase-like protein 0.0079 0.1025 1
Trichomonas vaginalis beta lactamase domain, putative 0.0079 0.1025 0.2115
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.011 0.0174
Schistosoma mansoni protein kinase 0.004 0.0419 0.0416
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0097 0.0199
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0079 0.1025 0.1649
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1739 0.1736
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.1025 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.1144 0.184
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0356 0.0701
Echinococcus granulosus lamin dm0 0.0033 0.0311 0.0308
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.004 0.0419 0.0795
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0487 0.2722
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0065 0.0812 0.0809
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0411 0.0847
Onchocerca volvulus 0.0019 0.0097 0.026
Trypanosoma brucei ISWI complex protein 0.0033 0.0313 0.2004
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0084 0.0136
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.2627
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0071
Echinococcus multilocularis ETHE1 protein 0.0079 0.1025 0.0983
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0891 0.57
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0046 0.052 0.0475
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0802 0.0799
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0221 0.0455
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0891 0.5454
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.03 0.0297
Schistosoma mansoni hypothetical protein 0.0044 0.0488 0.0485
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0391 0.0388
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.0485
Loa Loa (eye worm) ctsf protein 0.0019 0.0097 0.0155
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0445 0.0715
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0356 0.0983
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.2627
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0043 0.0473 0.4135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Echinococcus granulosus solute carrier family 22 0.0018 0.0084 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.071 0.423
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0043 0.0473 0.4602
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.203 0.1992
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0115 0.1563 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.0155
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0391 0.0388
Schistosoma mansoni inositol monophosphatase 0.0074 0.0943 0.094
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0311 0.0499
Schistosoma mansoni pyruvate kinase 0.0036 0.0356 0.0354
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0356 0.2891
Echinococcus granulosus cathepsin l1 0.0019 0.0097 0.0094
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0097 0.0015
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0812 0.1302
Schistosoma mansoni sex comb on midleg homolog 0.0102 0.1372 0.1369
Brugia malayi Cathepsin L-like precursor 0.0019 0.0097 0.015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Trichomonas vaginalis beta lactamase domain, putative 0.0079 0.1025 0.2115
Brugia malayi metallo-beta-lactamase superfamily protein 0.0079 0.1025 0.1645
Echinococcus granulosus ETHE1 protein 0.0079 0.1025 0.1023
Echinococcus granulosus pyruvate kinase 0.0018 0.0092 0.0089
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0079 0.1025 0.2843
Schistosoma mansoni ap endonuclease 0.0043 0.0473 0.0471
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.004 0.0419 0.0674
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0084 0.0174
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0473 0.0976
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Onchocerca volvulus 0.0018 0.0084 0.0226
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0262 0.0421
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0115 0.1563 1
Echinococcus multilocularis lamin 0.0033 0.0311 0.0265
Schistosoma mansoni zinc finger protein 0.0044 0.0479 0.0476
Mycobacterium tuberculosis Conserved protein 0.0079 0.1025 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0102 0.1372 0.3805
Schistosoma mansoni hypothetical protein 0.0019 0.0104 0.0101
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0391 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.1025 0.2115
Echinococcus multilocularis SAM and MBT domain containing protein 0.0102 0.1372 0.1331
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0104 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0441 0.0706
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0732 0.1178
Trypanosoma cruzi ISWI complex protein 0.0033 0.0313 0.1548
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.008 0.0128
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0488 0.0784
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0437 0.0392
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0079 0.1025 1
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0079 0.1025 0.6362
Brugia malayi hypothetical protein 0.0018 0.0084 0.0131
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0356 0.0983
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.203 0.2027
Brugia malayi Bromodomain containing protein 0.0034 0.0339 0.0541
Plasmodium vivax calcium-dependent protein kinase, putative 0.004 0.0419 0.0423
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.011 0.0704
Mycobacterium ulcerans hypothetical protein 0.0079 0.1025 0.2086
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0084 0.0131
Leishmania major cathepsin L-like protease 0.0019 0.0097 0.0082
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0445 0.0442
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0943 0.5804
Schistosoma mansoni hypothetical protein 0.063 0.9417 0.9417
Leishmania major cathepsin L-like protease 0.0019 0.0097 0.0082
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0084 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0243 0.0462
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0221 0.1413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0097 0.0199
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.2627
Plasmodium falciparum pyruvate kinase 0.0036 0.0356 0.0344
Onchocerca volvulus 0.0018 0.0084 0.0226
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0812 0.4919
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0097 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0617 0.1171
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0124 0.0264
Mycobacterium tuberculosis Possible hydrolase 0.0079 0.1025 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0857 0.1378
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.011 0.0107
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.018 0.0285
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0084 0.0174
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.2627
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0356 0.0569
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0243 0.024
Entamoeba histolytica metallo-beta-lactamase family protein 0.0079 0.1025 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0221 0.0218
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.004 0.0419 0.0795
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0473 0.0492
Echinococcus granulosus GPCR family 2 0.0019 0.0104 0.0101
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0079 0.1025 0.6362
Schistosoma mansoni intermediate filament proteins 0.0033 0.0311 0.0308
Onchocerca volvulus 0.0019 0.0097 0.026
Echinococcus multilocularis pyruvate kinase 0.0028 0.0242 0.0196
Trichomonas vaginalis set domain proteins, putative 0.0248 0.3599 0.7423
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.011 0.0172
Brugia malayi Sugar transporter family protein 0.0018 0.0084 0.0131
Echinococcus granulosus zinc phosphodiesterase 0.0079 0.1025 0.1023
Toxoplasma gondii sugar transporter ST3 0.0018 0.0084 0.016
Chlamydia trachomatis ribonuclease Z 0.0079 0.1025 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0097 0.0199
Schistosoma mansoni inositol transporter 0.0046 0.052 0.0517
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0084 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0097 0.0199
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.011 0.1048
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0124 0.079
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0204 0.2929 0.2927
Echinococcus granulosus histone acetyltransferase MYST2 0.0116 0.1587 0.1585
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0857 0.0854
Echinococcus multilocularis solute carrier family 22 0.0018 0.0084 0.0038
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0097 0.0094
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.3141 0.5053
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Schistosoma mansoni lamin 0.0033 0.0311 0.0308
Entamoeba histolytica hypothetical protein, conserved 0.0079 0.1025 1
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0391 0.2075
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.0812 0.5193
Echinococcus multilocularis pyruvate kinase 0.0036 0.0356 0.0311
Mycobacterium ulcerans hypothetical protein 0.0079 0.1025 0.2086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0097 0.0199
Mycobacterium tuberculosis Conserved protein 0.0079 0.1025 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0111 0.0178
Loa Loa (eye worm) hypothetical protein 0.0046 0.052 0.0836
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.071 0.6648
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0411 0.2207
Loa Loa (eye worm) hypothetical protein 0.0148 0.2071 0.3331
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.011 0.0704
Schistosoma mansoni zinc phosphodiesterase 0.0079 0.1025 0.1023
Trypanosoma brucei sugar transporter, putative 0.0018 0.0084 0.054
Trypanosoma brucei unspecified product 0.0065 0.0812 0.5193
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0391 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Mycobacterium leprae POSSIBLE HYDROLASE 0.0079 0.1025 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0097 0.0199
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0356 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0487 0.2722
Brugia malayi Cathepsin L-like precursor 0.0019 0.0097 0.015
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0262 0.0497
Echinococcus multilocularis mitogen activated protein kinase 0.0115 0.1563 0.1524
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0065 0.0812 0.0769
Schistosoma mansoni pyruvate kinase 0.0036 0.0356 0.0354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0097 0.0199
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0311 0.0499
Plasmodium falciparum phd finger protein, putative 0.0029 0.0262 0.0224
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.071 0.0707
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.203 0.1992
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.1563 0.3224
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0092 0.0175
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Mycobacterium ulcerans glutaminase 0.033 0.4849 1
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0812 0.1644
Brugia malayi hypothetical protein 0.0079 0.1025 0.1645
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.071 0.1348
Schistosoma mansoni protein kinase 0.004 0.0419 0.0416
Leishmania major glucose transporter, lmgt1 0.0039 0.0411 0.2207
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0243 0.0197
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.1025 1
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0243 0.224
Loa Loa (eye worm) hypothetical protein 0.0028 0.0243 0.0392
Trypanosoma cruzi glyoxalase II 0.0079 0.1025 0.6362
Brugia malayi ethe1-prov protein 0.0079 0.1025 0.1645
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0243 0.0467
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.005 0.0576 0.0573
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.066 0.3895
Onchocerca volvulus 0.0018 0.0084 0.0226
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0084 0.0081
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0043 0.0473 0.0471
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0097 0.0094
Echinococcus granulosus pyruvate kinase 0.0018 0.0092 0.0089
Schistosoma mansoni high-affinity choline transporter 0.042 0.6217 0.6216
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0079 0.1025 0.6362
Leishmania major cathepsin L-like protease 0.0019 0.0097 0.0082
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0356 0.0735
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0084 0.0081
Echinococcus multilocularis fetal alzheimer antigen, falz 0.005 0.0576 0.0532
Entamoeba histolytica protein kinase, putative 0.004 0.0419 0.4066
Echinococcus multilocularis musashi 0.0033 0.0311 0.0265
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0943 0.5804
Entamoeba histolytica hypothetical protein 0.0043 0.0476 0.4631
Echinococcus granulosus sodium:myo inositol cotransporter 0.0046 0.052 0.0517
Brugia malayi Sugar transporter family protein 0.0126 0.1739 0.2794
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.011 0.0174
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.1563 0.3224
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0262 0.0259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.1563 0.3224
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0812 0.4919
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0812 0.5193
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0079 0.1025 1
Brugia malayi hypothetical protein 0.0018 0.0084 0.0131
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0356 0.1839
Schistosoma mansoni hypothetical protein 0.0019 0.0104 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0812 0.5193
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0079 0.1025 0.6559
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0097 0.0199
Trypanosoma cruzi glyoxalase II 0.0079 0.1025 0.6362
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0205 0.294 0.5581
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0124 0.0264
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0943 0.1944
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Trypanosoma brucei glucose transporter 1E 0.0039 0.0411 0.2627
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1739 0.1736
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0487 0.2722
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.011 0.0177
Schistosoma mansoni sugar transporter 0.0018 0.0084 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0411 0.0847
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.019 0.0393
Echinococcus granulosus solute carrier family 22 0.0018 0.0084 0.0081
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0079 0.1025 0.2115
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0891 0.5454
Onchocerca volvulus 0.0019 0.0097 0.026
Mycobacterium ulcerans hypothetical protein 0.002 0.0124 0.0219
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0411 0.6086 0.6067
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0124 0.079
Brugia malayi Sodium:solute symporter family protein 0.0046 0.052 0.0832
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0356 0.0573
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0411 0.0847
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0097 0.0199
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.011 0.0704
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0084 0.0131
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0097 0.0094
Echinococcus multilocularis polycomb protein SCMH1 0.0102 0.1372 0.1331
Plasmodium falciparum calcium-dependent protein kinase 3 0.004 0.0419 0.0423
Echinococcus granulosus zinc finger protein 0.0044 0.0479 0.0476
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0179 0.1002
Loa Loa (eye worm) hypothetical protein 0.0033 0.0311 0.0499
Echinococcus granulosus pyruvate kinase 0.0018 0.0092 0.0089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Echinococcus multilocularis pyruvate kinase 0.0036 0.0356 0.0311
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0065 0.0812 0.0809
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0097 0.026
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Schistosoma mansoni hypothetical protein 0.0126 0.1739 0.1736
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0097 0.0199
Plasmodium vivax hexose transporter 0.0126 0.1739 0.209
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0164 0.0537
Giardia lamblia DINP protein human, muc B family 0.0065 0.0812 0.4919
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Loa Loa (eye worm) hypothetical protein 0.0053 0.0617 0.0992
Schistosoma mansoni inositol transporter 0.0046 0.052 0.0517
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.0419 0.0416
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0243 0.0502
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0661 0.133
Mycobacterium ulcerans hypothetical protein 0.0079 0.1025 0.2086
Onchocerca volvulus 0.0102 0.1372 0.3805
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0124 0.0264
Schistosoma mansoni sex comb on midleg homolog 0.0102 0.1372 0.1369
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0115 0.1563 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0124 0.079
Entamoeba histolytica deoxycytidyl transferase, putative 0.0065 0.0812 0.7912
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0487 0.0509
Mycobacterium ulcerans hydrolase 0.0079 0.1025 0.2086
Schistosoma mansoni cpg binding protein 0.0036 0.036 0.0357
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0043 0.0473 0.0943
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.011 0.0174
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0356 0.0344
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.1025 0.2115
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0476 0.0432
Brugia malayi jmjC domain containing protein 0.0041 0.0445 0.0711
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0272 0.0269
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0124 0.0049
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.2627
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0243 0.1557
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0043 0.0473 0.4135
Leishmania major DNA polymerase kappa, putative 0.002 0.0124 0.0264
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0084 0.0136
Schistosoma mansoni hypothetical protein 0.0033 0.0313 0.031
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0115 0.1563 0.2515
Loa Loa (eye worm) hypothetical protein 0.0102 0.1372 0.2206
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0079 0.1025 0.1023
Brugia malayi MAP kinase sur-1 0.0115 0.1563 0.2511
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0097 0.005
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0084 0.0138
Echinococcus multilocularis dna polymerase kappa 0.0065 0.0812 0.0769
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0205 0.294 0.3608
Plasmodium vivax SET domain protein, putative 0.0032 0.03 0.0272
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0092 0.001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0943 0.5804
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0115 0.1563 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.0419 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.1025 0.2115
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0097 0.005
Brugia malayi hypothetical protein 0.0018 0.0084 0.0131
Plasmodium falciparum mitogen-activated protein kinase 2 0.0205 0.294 0.3608
Brugia malayi Cathepsin L-like precursor 0.0019 0.0097 0.015
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0371 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0084 0.0174
Mycobacterium leprae conserved hypothetical protein 0.0079 0.1025 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0391 0.2511
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0116 0.1587 0.1548
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0097 0.0082
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0943 0.09
Entamoeba histolytica alkyl sulfatase, putative 0.0079 0.1025 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0116 0.1587 0.1585
Echinococcus granulosus peregrin 0.0034 0.0339 0.0336
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0043 0.0473 0.2631
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.0419 0.0374
Schistosoma mansoni hypothetical protein 0.0041 0.0441 0.0439
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0079 0.1025 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0097 0.015
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.0419 0.0416
Loa Loa (eye worm) hypothetical protein 0.0038 0.0391 0.0629
Toxoplasma gondii exonuclease III APE 0.0043 0.0473 0.0899
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0356 0.21
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0097 0.005
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1576 0.2535
Mycobacterium ulcerans hydrolase 0.0079 0.1025 0.2086
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0077 0.0987 0.0945
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0097 0.0094
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0411 0.2207
Plasmodium vivax unspecified product 0.0079 0.1025 0.1189
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0798 0.4822
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0367 0.0364
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0084 0.0131
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.2627
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0071
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0124 0.0234
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.011 0.0177
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.1025 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0124 0.079
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0262 0.0259
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0124 0.079
Loa Loa (eye worm) mbt repeat family protein 0.0102 0.1372 0.2206
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0411 0.0847
Echinococcus multilocularis GPCR, family 2 0.0019 0.0104 0.0058
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1739 0.17
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0084 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.1025 0.2115
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.071 0.0707
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.203 0.2027
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.004 0.0419 0.0669
Schistosoma mansoni glucose transport protein 0.0126 0.1739 0.1736
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.203 0.3262
Loa Loa (eye worm) hypothetical protein 0.042 0.6217 1
Echinococcus multilocularis microtubule associated protein 2 0.0668 1 1
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0097 0.026
Brugia malayi hypothetical protein 0.0053 0.0617 0.0988
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0891 0.57
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0097 0.005
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Mycobacterium ulcerans hydrolase 0.0079 0.1025 0.2086
Brugia malayi hypothetical protein 0.0148 0.2071 0.3327
Leishmania major cathepsin L-like protease 0.0071 0.0891 0.5454
Schistosoma mansoni hypothetical protein 0.0019 0.0104 0.0101
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0204 0.2929 0.2896
Onchocerca volvulus 0.0018 0.0084 0.0226
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1739 0.1736
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.03 0.0569
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.1282 0.1279
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.0419 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0812 0.5193
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0419 0.0416
Trypanosoma brucei unspecified product 0.0045 0.0502 0.3212
Giardia lamblia Kinase, CMGC MAPK 0.0115 0.1563 1
Onchocerca volvulus 0.0019 0.0097 0.026
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0221 0.0419
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.011 0.0174
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0174 0.0171
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.011 0.0174
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.011 0.1048
Onchocerca volvulus 0.0033 0.0311 0.0855
Echinococcus multilocularis mitogen activated protein kinase 3 0.0115 0.1563 0.1524
Loa Loa (eye worm) hypothetical protein 0.0245 0.3557 0.5721
Echinococcus multilocularis histone acetyltransferase MYST2 0.0116 0.1587 0.1548
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0739 0.1189
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0661 0.6122
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0115 0.1563 1
Echinococcus granulosus intermediate filament protein 0.0033 0.0311 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0003 0.0006
Brugia malayi Bromodomain containing protein 0.0162 0.2289 0.3679
Echinococcus multilocularis pyruvate kinase 0.0018 0.0092 0.0046
Echinococcus granulosus solute carrier family 22 0.0018 0.0084 0.0081
Brugia malayi PHD-finger family protein 0.0015 0.0049 0.0074
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0943 0.179
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.004 0.0419 0.0416
Mycobacterium tuberculosis Possible hydrolase 0.0079 0.1025 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0617 0.0673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0943 0.1944
Brugia malayi exodeoxyribonuclease III family protein 0.0043 0.0473 0.0757
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0084 0.0174
Loa Loa (eye worm) hypothetical protein 0.0079 0.1025 0.1649
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0124 0.0234
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.0857 0.0854
Schistosoma mansoni DNA polymerase eta 0.0065 0.0812 0.0809
Onchocerca volvulus 0.0033 0.0311 0.0855
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0243 0.0201
Leishmania major DNA polymerase eta, putative 0.0065 0.0812 0.4919
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0097 0.0199
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0776 0.1473
Brugia malayi jmjC domain containing protein 0.0096 0.1282 0.2058
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0079 0.1025 0.1023
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.013 0.179 0.1751
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0065 0.0812 0.4919
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0192 0.0309
Leishmania major hypothetical protein, conserved 0.0053 0.0617 0.3601
Onchocerca volvulus 0.0018 0.0084 0.0226
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.2627
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0617 0.3601
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.203 0.2027
Loa Loa (eye worm) hypothetical protein 0.0025 0.0192 0.0309
Brugia malayi GH02984p 0.042 0.6217 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0391 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0943 0.9192
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0124 0.079
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0243 0.1075
Leishmania major DNA polymerase eta, putative 0.002 0.0124 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0179 0.1002
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0079 0.1025 0.6362
Leishmania major glucose transporter, lmgt3 0.0039 0.0411 0.2207
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.0857 0.0813
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0371 0.0368
Echinococcus granulosus cpg binding protein 0.0036 0.036 0.0357
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Schistosoma mansoni glucose transport protein 0.0126 0.1739 0.1736
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.011 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0891 0.57
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0084 0.0174
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0084 0.0081
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0097 0.0155
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1739 0.1736
Schistosoma mansoni inositol monophosphatase 0.0074 0.0943 0.094
Leishmania major hypothetical protein, conserved 0.0079 0.1025 0.6362
Schistosoma mansoni protein kinase 0.004 0.0419 0.0416
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0097 0.0199
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.2627
Loa Loa (eye worm) hypothetical protein 0.002 0.0124 0.0199
Mycobacterium ulcerans sugar transporter 0.0018 0.0084 0.0138
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0824 0.7627
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0245 0.3557 0.5719
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0192 0.1851
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0046 0.052 0.0475
Schistosoma mansoni glucose transporter 0.0018 0.0084 0.0081
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0097 0.0199
Schistosoma mansoni glucose transport protein 0.0126 0.1739 0.1736
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0097 0.0199
Brugia malayi Cam kinase protein 1 0.004 0.0419 0.0669
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.1563 0.1561
Mycobacterium tuberculosis Beta lactamase like protein 0.0079 0.1025 1
Leishmania major cathepsin L-like protease 0.0071 0.0891 0.5454
Onchocerca volvulus 0.0079 0.1025 0.2843
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.071 0.0666
Treponema pallidum ribonuclease Z 0.0079 0.1025 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.1282 0.124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0097 0.0199
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0116 0.1587 0.2549
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0079 0.1025 0.2086
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.203 0.3265
Loa Loa (eye worm) inositol-1 0.0074 0.0943 0.1517
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.071 0.0707
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0943 0.6031
Brugia malayi Cathepsin L-like precursor 0.0019 0.0097 0.015
Onchocerca volvulus Huntingtin homolog 0.0148 0.2071 0.5749
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0016 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.0031 0.0283 0.0455
Trichomonas vaginalis apoptosis inducing factor, putative 0.0079 0.1025 0.2115
Giardia lamblia Pyruvate kinase 0.0018 0.0092 0.0053
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0391 0.0625
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.004 0.0419 0.0423
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0812 0.1302
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.071 0.1433
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0079 0.1025 0.6362
Toxoplasma gondii cathepsin CPL 0.0019 0.0097 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0097 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0084 0.0174
Mycobacterium ulcerans hypothetical protein 0.0079 0.1025 0.2086
Loa Loa (eye worm) hypothetical protein 0.0079 0.1025 0.1649
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0356 0.1839
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0391 0.0346
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0272 0.0437
Echinococcus multilocularis solute carrier family 22 0.0018 0.0084 0.0038
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.0891 0.5454
Echinococcus granulosus polycomb protein SCMH1 0.0102 0.1372 0.1369
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0079 0.1025 0.1023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0812 0.4919
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1739 0.17
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0891 0.57
Trypanosoma brucei glyoxalase II 0.0079 0.1025 0.6559
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0891 0.57
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0115 0.1563 0.2968
Loa Loa (eye worm) glutaminase 0.033 0.4849 0.78
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0411 0.0847
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.011 0.0174
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0097 0.0914
Entamoeba histolytica alkyl sulfatase, putative 0.0079 0.1025 1
Leishmania major cathepsin L-like protease 0.0019 0.0097 0.0082
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0311 0.0495
Onchocerca volvulus 0.0018 0.0084 0.0226
Treponema pallidum exodeoxyribonuclease (exoA) 0.0043 0.0473 0.4523
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0812 0.5193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0097 0.0199
Trypanosoma brucei glucose transporter 2A 0.0039 0.0411 0.2627
Schistosoma mansoni hypothetical protein 0.0079 0.1025 0.1023
Leishmania major glucose transporter, lmgt2 0.0039 0.0411 0.2207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0371 0.0368
Loa Loa (eye worm) hypothetical protein 0.0079 0.1025 0.1649
Schistosoma mansoni sugar transporter 0.0018 0.0084 0.0081
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0102 0.1372 0.1369
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.0419 0.0374
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0812 0.5193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0097 0.0199
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0221 0.0922
Trypanosoma cruzi hexose transporter 0.0039 0.0411 0.2207
Entamoeba histolytica hypothetical protein 0.0043 0.0476 0.4631
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0476 0.0474
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0243 0.1075
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0812 0.5193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.011 0.0227
Onchocerca volvulus Alhambra homolog 0.0029 0.0262 0.072
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0812 0.5193
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0097 0.0199
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0079 0.1025 0.6362
Onchocerca volvulus 0.0019 0.0097 0.026
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0943 0.1915
Onchocerca volvulus 0.0019 0.0097 0.026
Echinococcus multilocularis solute carrier family 22 0.0018 0.0084 0.0038
Trypanosoma cruzi hexose transporter, putative 0.0021 0.014 0.0376
Onchocerca volvulus 0.0018 0.0084 0.0226
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.011 0.0174
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0262 0.0497
Loa Loa (eye worm) hypothetical protein 0.0036 0.0356 0.0573
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0046 0.052 0.0517
Schistosoma mansoni pyruvate kinase 0.0018 0.0092 0.0089

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. ChEMBL. 22096101
CC50 (functional) = 49.7 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
CC50 = 49.7 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) = 283 nM MMV: Inhibition of Plasmodium falciparum 3D7 (EC50). ChEMBL. No reference
EC50 (functional) = 0.442 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.442 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) = 1.005 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) = 1.005 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
Growth Inhibition (functional) = 11.5806 % MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. ChEMBL. No reference
IC50 (functional) = 369.5 nM MMV: IC50 determined against P. falciparum Dd2-luc strain using a Malaria Sybr Green I Fluorescence assay. Starting conditions were 1% trophozoite synchronised parasites at 2% haematocrit. Fluorescence detection completed after 48hr incubation at 37 degrees C under 1% O2, 3% CO2 and balance N2. ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) = 0.204 uM MMV: Modified 3H-Hyoxanthine uptake assay; RPMI 1640 (Invitrogen cat#23400-013) without Sodium Bicarbonate (NaHCO3). ChEMBL. No reference
IC50 (functional) = 0.246 uM MMV: 3H-Hyoxanthine uptake assay; RPMI 1640 (Invitrogen cat#11875-093) with Sodium Bicarbonate (NaHCO3) 2000 mg/mL. ChEMBL. No reference
IC50 (functional) = 0.443 uM MMV: 3H-Hyoxanthine uptake assay; 5% O2, 5% CO2 in N2. ChEMBL. No reference
IC50 (functional) = 0.702 uM MMV: Modified 3H-Hyoxanthine uptake assay; 1% O2, 5% CO2 in N2. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) = 16.122337341308594 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 (functional) = 16.1223373413086 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 (functional) = 17.1353187561035 uM MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). ChEMBL. No reference
IC50 (functional) = 25.398416519165 uM MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. ChEMBL. No reference
IC50 (functional) = 25.39841651916504 uM MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. ChEMBL. No reference
IC50 = 25.60886573791504 uM MMV: Cytotoxicity against human fibroblasts (MRC-5) cells. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). ChEMBL. No reference
IFI promiscuity index = 0 IFI promiscuity index Novartis-GNF Malaria Box. No reference
Inhibition (functional) = -139.21103020940123 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -139.211030209401 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -4.89086908659465 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -0.6954343511294994 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -0.695434351129499 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 4 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 20.1 % MMV: Screen against Mtb, single point, non replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 23.4 % MMV: Screen against Mtb, single point, replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 25 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 33.719345137166 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = 33.71934513716601 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
IZ = 0 mm MMV: Selection for compounds that exhibit enhanced toxicity in combination with artemisinin. Assay utilized the disc diffusion method with the observance of a clear zone indicating inhibition of growth. Synthetic complete medium containing 3% glycerol as a carbon source (SCG) was used in each assay. 10 uL of each compound was added to a paper disc which was placed on SCG and SCG+Artemisinin (0.2 uM) plates seeded with 10e6 yeast cells (WC081 strain: Mat a, leu2 delta 0, lys2 delta 0, ura3 delta 0, his3 delta 1, pdr1 delta::HIS3, pdr3 delta::kanMX4, derived from BY4742, regulators of Multi-drug resistance transporters have been deleted to enhance toxicity of compounds). Plates were incubated at 30 degrees C for 5 days and clear zones were measured. Compounds that produced a larger clear zone in the presence of artemisinin was considered to have an additive interaction with artemisinin. Results are reported as diameter of clear zone on SCG+artemisinin plates - diameter of clear zone on SCG plates without artemisinin. ChEMBL. No reference
Ratio (functional) = 0.9 MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. ChEMBL. No reference
Relative Growth (functional) = -0.103 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing ethanol and glycerol as carbon sources (Yeast Nitrogen Base, Ethanol, Glycerol; YNBEG). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 180 OD readings, corresponding to roughly 45 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = 0.0151 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in rich media containing dextrose as a carbon source (Yeast Extract, Peptone, Dextrose; YPD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = 0.1423 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783
Trypanosoma cruzi ChEMBL23
Trypanosoma brucei gambiense

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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