pI: 4.3759 |
Length (AA): 982 |
MW (Da): 108886 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 9 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
146 | 838 | 2f2h (A) | 2 | 773 | 10.00 | 0 | 0.98 | 0.31 | 1.2 |
350 | 770 | 1zy9 (A) | 77 | 520 | 16.00 | 0 | 1 | 0.38 | 0.3 |
441 | 821 | 1ktb (A) | 2 | 383 | 35.00 | 0 | 1 | 0.8 | -1.2 |
275 | 323 | 1qmj (A) | 64 | 114 | 47.00 | 0.38 | 0.08 | 0.346498 | 0.71 |
352 | 817 | 4ogz (A) | 36 | 494 | 28.00 | 0 | 1 | 0.744242 | -0.08 |
441 | 784 | 3hg3 (A) | 33 | 375 | 36.00 | 0 | 1 | 0.809005 | -0.87 |
446 | 980 | 3a21 (A) | 54 | 546 | 26.00 | 0 | 1 | 0.629507 | 0.37 |
446 | 822 | 4do4 (A) | 24 | 402 | 35.00 | 0 | 1 | 0.80461 | -0.69 |
870 | 981 | 2w87 (A) | 31 | 132 | 10.00 | 0.32 | 0.01 | 0.090753 | -0.24 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | ME49 Bradyzoite. | Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite. | Gregory |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Tachyzoite, ME49 Oocyst. | Gregory Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | ME49 merozoite. | Hehl AB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Gregory | ToxoDB |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_127620)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G56310 | melibiase family protein |
Arabidopsis thaliana | AT5G08380 | alpha-galactosidase 1 |
Arabidopsis thaliana | AT5G08370 | alpha-galactosidase 2 |
Brugia malayi | Bm1_51545 | Melibiase family protein |
Caenorhabditis elegans | CELE_R07B7.11 | Protein GANA-1 |
Dictyostelium discoideum | DDB_G0271490 | hypothetical protein |
Dictyostelium discoideum | DDB_G0291524 | glycoside hydrolase family 27 protein |
Drosophila melanogaster | Dmel_CG7997 | CG7997 gene product from transcript CG7997-RB |
Drosophila melanogaster | Dmel_CG5731 | CG5731 gene product from transcript CG5731-RA |
Echinococcus granulosus | EgrG_000340500 | Alpha N acetylgalactosaminidase |
Echinococcus multilocularis | EmuJ_000340500 | Alpha N acetylgalactosaminidase |
Echinococcus multilocularis | EmuJ_000340400 | Glycoside hydrolase, family 27 |
Homo sapiens | ENSG00000102393 | galactosidase, alpha |
Homo sapiens | ENSG00000198951 | N-acetylgalactosaminidase, alpha- |
Loa Loa (eye worm) | LOAG_00060 | hypothetical protein |
Mus musculus | ENSMUSG00000031266 | galactosidase, alpha |
Mus musculus | ENSMUSG00000022453 | N-acetyl galactosaminidase, alpha |
Neospora caninum | NCLIV_054050 | hypothetical protein |
Oryza sativa | 4348988 | Os10g0493600 |
Oryza sativa | 4348984 | Os10g0492900 |
Oryza sativa | 4344290 | Os07g0679300 |
Schistosoma japonicum | Sjp_0023240 | Alpha-N-acetylgalactosaminidase precursor, putative |
Schistosoma japonicum | Sjp_0023210 | expressed protein |
Schistosoma japonicum | Sjp_0023250 | Alpha-N-acetylgalactosaminidase, putative |
Schistosoma japonicum | Sjp_0023260 | ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative |
Schistosoma japonicum | Sjp_0107620 | Alpha-N-acetylgalactosaminidase, putative |
Schistosoma japonicum | Sjp_0023220 | Alpha-N-acetylgalactosaminidase, putative |
Schistosoma mansoni | Smp_089290 | alpha-galactosidase/alpha-n-acetylgalactosaminidase |
Schistosoma mansoni | Smp_179260 | alpha-galactosidase/alpha-n-acetylgalactosaminidase |
Schistosoma mansoni | Smp_179250 | alpha-galactosidase/alpha-n-acetylgalactosaminidase |
Schistosoma mansoni | Smp_186710 | alpha-galactosidase/alpha-n-acetylgalactosaminidase |
Schistosoma mansoni | Smp_170830 | alpha-galactosidase/alpha-n-acetylgalactosaminidase |
Schistosoma mansoni | Smp_170840 | alpha-galactosidase/alpha-n-acetylgalactosaminidase |
Schmidtea mediterranea | mk4.003634.02 | |
Schmidtea mediterranea | mk4.005290.02 | |
Schmidtea mediterranea | mk4.000843.06 | |
Toxoplasma gondii | TGME49_309930 | melibiase subfamily protein |
Trichomonas vaginalis | TVAG_145340 | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_309930 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Coffea arabica | Alpha-galactosidase | Compounds | References |
Coffea arabica | Alpha-galactosidase | Compounds | References |
Rattus norvegicus | Alpha-galactosidase A | Compounds | References |
Homo sapiens | galactosidase, alpha | Compounds | References |