Detailed information for compound 1107983

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 367.511 | Formula: C20H25N5S
  • H donors: 1 H acceptors: 2 LogP: 5.05 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(Cc1cccc(c1)/C=N/Nc1ncnc2c1cc(s2)C(C)(C)C)C
  • InChi: 1S/C20H25N5S/c1-20(2,3)17-10-16-18(21-13-22-19(16)26-17)24-23-11-14-7-6-8-15(9-14)12-25(4)5/h6-11,13H,12H2,1-5H3,(H,21,22,24)/b23-11+
  • InChiKey: QMILTDKFGBLVQN-FOKLQQMPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin E1 Starlite/ChEMBL References
Homo sapiens cyclin D1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_133273 All targets in OG5_133273
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_133273 All targets in OG5_133273
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0017 0.0142
Schistosoma mansoni hypothetical protein 0.0284 0.0229 0.0228
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0073 0.0044 0.0161
Brugia malayi Cathepsin L-like precursor 0.006 0.0032 0.0149
Brugia malayi jmjC domain containing protein 0.0152 0.0113 0.0525
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0073 0.0044 0.1407
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0247 0.0196 0.0723
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.0044 0.0201
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0002 0.0002
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0073 0.0044 0.0161
Schistosoma mansoni ap endonuclease 0.0092 0.0061 0.006
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0001 0.0002
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0032 0.0008 0.0037
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0032 0.0008 0.0008
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0032 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0024 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.002 0.0168
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0073 0.0044 0.1395
Trichomonas vaginalis rotamase, putative 0.0031 0.0007 0.0061
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.003 0.0139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0032 0.0279
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0017 0.0547
Onchocerca volvulus Cathepsin F homolog 0.006 0.0032 0.0279
Brugia malayi Inositol monophosphatase family protein 0.0026 0.0003 0.0011
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0044 0.0161
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0319 0.026 0.8359
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0002 0.0002
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0092 0.0061 0.1958
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0105 0.34
Echinococcus granulosus peptidase Clp S14 family 0.0209 0.0163 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0019 0.0609
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0006 0.0205
Echinococcus multilocularis tumor protein p63 0.3158 0.2745 0.2745
Brugia malayi PHD-finger family protein 0.0025 0.0002 0.0007
Loa Loa (eye worm) glutathione reductase 0.0087 0.0056 0.0258
Leishmania major acetyl-CoA synthetase, putative 0.0073 0.0044 0.1407
Plasmodium vivax acetyl-CoA synthetase, putative 0.0073 0.0044 0.1348
Mycobacterium tuberculosis Probable hydrolase 0.0377 0.031 0.1142
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0042 0.0017 0.0142
Plasmodium vivax acyl-CoA synthetase, putative 0.0185 0.0142 0.4534
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0062 0.0035 0.0848
Loa Loa (eye worm) hypothetical protein 0.004 0.0015 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.006 0.0032 0.0279
Onchocerca volvulus 0.006 0.0032 0.0279
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0032 0.0008 0.0008
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0247 0.0196 0.632
Onchocerca volvulus 0.0462 0.0385 0.3351
Mycobacterium tuberculosis Monophosphatase CysQ 0.0026 0.0003 0.001
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0032 0.0008 0.0037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0377 0.031 0.031
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0208 0.0162 0.5218
Brugia malayi Glycosyl hydrolases family 31 protein 0.0062 0.0035 0.0159
Loa Loa (eye worm) hypothetical protein 0.004 0.0015 0.0068
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0032 0.1017
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0247 0.0196 0.6295
Brugia malayi PHD-finger family protein 0.0028 0.0005 0.002
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0014 0.0337
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0003 0.0018
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0035 0.0011 0.034
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0221 0.0173 0.0629
Brugia malayi nuclear hormone receptor family member odr-7 0.0023 0.0001 0.0001
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0032 0.0008 0.007
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0032 0.0031
Brugia malayi MH2 domain containing protein 0.003 0.0006 0.0027
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0152 0.0113 0.0113
Loa Loa (eye worm) inositol-1 0.0247 0.0196 0.091
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0006 0.0193
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0152 0.0151
Schistosoma mansoni hypothetical protein 0.0043 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0377 0.031 0.1441
Loa Loa (eye worm) latrophilin receptor protein 2 0.0215 0.0168 0.0781
Echinococcus multilocularis expressed conserved protein 0.0099 0.0067 0.0067
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0005 0.0023
Echinococcus granulosus cathepsin l1 0.006 0.0032 0.0032
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0169 0.0128 0.4144
Echinococcus granulosus ubiquitin specific protease 41 0.0206 0.0161 0.016
Brugia malayi nuclear hormone receptor 0.005 0.0024 0.0108
Echinococcus multilocularis muscleblind protein 1 0.0465 0.0387 0.0387
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0169 0.0128 0.0128
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0029 0.0005 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0019 0.0596
Echinococcus multilocularis muscleblind protein 0.0465 0.0387 0.0387
Echinococcus multilocularis geminin 0.1534 0.1323 0.1323
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0024 0.0023
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0026 0.0003 0.0075
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0024 0.0023
Leishmania major pyruvate kinase 0.0029 0.0005 0.0176
Loa Loa (eye worm) Smad1 0.0067 0.0039 0.0177
Leishmania major cathepsin L-like protease 0.0228 0.0179 0.5782
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0024 0.0023
Entamoeba histolytica cysteine protease, putative 0.0031 0.0007 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0053 0.0462
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0175 0.0133 0.049
Brugia malayi nuclear receptor NHR-88 0.0023 0.0001 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0012
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0001 0.0001
Onchocerca volvulus 0.0247 0.0196 0.1708
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0105 0.3392
Echinococcus multilocularis snurportin 1 0.0284 0.0229 0.0229
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0006 0.0138
Trypanosoma brucei trypanothione reductase 0.0087 0.0056 0.1802
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.0112 0.0111
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0032 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0024 0.0108
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1172 0.1006 0.4682
Echinococcus multilocularis peptidase Clp (S14 family) 0.0209 0.0163 0.0163
Schistosoma mansoni GTP-binding protein alpha subunit 0.0032 0.0008 0.0008
Echinococcus granulosus expressed conserved protein 0.0099 0.0067 0.0066
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0007 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.006 0.0032 0.0279
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0025 0.081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0005 0.0037
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0028 0.0005 0.0151
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0206 0.0161 0.0161
Toxoplasma gondii target of rapamycin (TOR), putative 0.0062 0.0035 0.1055
Echinococcus granulosus cpg binding protein 0.02 0.0155 0.0155
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0017 0.0547
Loa Loa (eye worm) hypothetical protein 0.0076 0.0046 0.0214
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0063 0.0036 0.0036
Trichomonas vaginalis alpha-glucosidase, putative 0.0062 0.0035 0.0298
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0319 0.026 0.0259
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0044 0.0201
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Onchocerca volvulus 0.006 0.0032 0.0279
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0024 0.0023
Toxoplasma gondii peptidylprolyl isomerase 0.003 0.0007 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0032 0.0279
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0073 0.0044 0.0044
Brugia malayi hypothetical protein 0.0076 0.0046 0.0214
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0073 0.0044 0.0161
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0012
Echinococcus multilocularis smad 0.0067 0.0039 0.0038
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0032 0.0008 0.0008
Brugia malayi Cyclin, N-terminal domain containing protein 0.0043 0.0018 0.008
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0006 0.0396
Plasmodium falciparum pyruvate kinase 0.0029 0.0005 0.013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0024 0.0108
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0026 0.0003 0.002
Loa Loa (eye worm) hypothetical protein 0.0045 0.002 0.009
Brugia malayi nuclear receptor NHR-67 0.0023 0.0001 0.0001
Echinococcus multilocularis zinc finger protein 0.0068 0.004 0.004
Schistosoma mansoni bromodomain containing protein 0.019 0.0147 0.0146
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0037
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0032 0.0008 0.007
Brugia malayi RNA binding protein 0.0196 0.0152 0.0703
Echinococcus granulosus histone acetyltransferase MYST2 0.016 0.012 0.0119
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0046 0.1488
Schistosoma mansoni sex comb on midleg homolog 0.014 0.0103 0.0103
Leishmania major 4-coumarate:coa ligase-like protein 0.0247 0.0196 0.6335
Echinococcus granulosus dnaJ subfamily B 0.1479 0.1275 0.1275
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Leishmania major glycosyl hydrolase-like protein 0.0023 0 0.0013
Trichomonas vaginalis penicillin-binding protein, putative 0.0377 0.031 0.2699
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0092 0.0061 0.006
Echinococcus granulosus dna polymerase kappa 0.0044 0.0019 0.0018
Leishmania major cathepsin L-like protease 0.006 0.0032 0.1044
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.01 0.0068 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0038 0.0331
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0052 0.0026 0.0025
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.0072 0.0335
Echinococcus multilocularis thyroid hormone receptor alpha 0.0178 0.0136 0.0136
Schistosoma mansoni smad 0.003 0.0006 0.0006
Mycobacterium tuberculosis Conserved protein 0.0377 0.031 0.1142
Schistosoma mansoni cathepsin F (C01 family) 0.004 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0027
Plasmodium falciparum glutathione reductase 0.003 0.0006 0.0165
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0084 0.0053 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0017 0.0142
Entamoeba histolytica cysteine protease, putative 0.0031 0.0007 0.0164
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0047 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0228 0.0179 0.5782
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0013 0.0408
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0043 0.0018 0.0018
Loa Loa (eye worm) mbt repeat family protein 0.014 0.0103 0.0477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0032 0.0279
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.0112 0.0111
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0006 0.0027
Brugia malayi Cyclin, N-terminal domain containing protein 0.0043 0.0018 0.008
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0073 0.0044 0.1395
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0024 0.0205
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0024 0.0023
Mycobacterium leprae Probable pyruvate kinase PykA 0.0029 0.0005 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0377 0.031 0.2699
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0024 0.0108
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0032 0.0008 0.0008
Mycobacterium ulcerans hypothetical protein 0.0377 0.031 0.1133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0053 0.0462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0228 0.0179 0.5782
Loa Loa (eye worm) phosphatidylinositol 3 0.0084 0.0053 0.0246
Schistosoma mansoni thyroid hormone receptor 0.0178 0.0136 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0754 0.064 0.064
Loa Loa (eye worm) MH2 domain-containing protein 0.0979 0.0837 0.3895
Schistosoma mansoni sex comb on midleg homolog 0.014 0.0103 0.0103
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0002 0.0068
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0019 0.0019
Echinococcus multilocularis expressed protein 0.0032 0.0008 0.0008
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0024 0.0108
Schistosoma mansoni zinc finger protein 0.0068 0.004 0.004
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0019 0.0161
Onchocerca volvulus 0.0172 0.013 0.1132
Schistosoma mansoni myelin transcription factor 1 myt1 0.016 0.012 0.012
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.003 0.0007 0.022
Echinococcus multilocularis cysteine protease 0.006 0.0032 0.0032
Echinococcus multilocularis ubiquitin specific protease 41 0.0206 0.0161 0.0161
Leishmania major acetyl-CoA synthetase, putative 0.0073 0.0044 0.1407
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0073 0.0044 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0019 0.0609
Brugia malayi Cathepsin L-like precursor 0.006 0.0032 0.0149
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0247 0.0196 0.0714
Brugia malayi Smad1 0.0067 0.0039 0.0177
Trichomonas vaginalis cyclin D, putative 0.0043 0.0018 0.015
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0228 0.0179 0.5782
Schistosoma mansoni hypothetical protein 0.0026 0.0003 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0377 0.031 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0073 0.0044 0.0151
Echinococcus granulosus cathepsin L 0.0031 0.0007 0.0006
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0007 0.0031
Mycobacterium tuberculosis Probable reductase 0.0197 0.0153 0.0563
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0152 0.0113 0.0113
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0169 0.0128 0.0473
Trichomonas vaginalis D-aminoacylase, putative 0.0377 0.031 0.2699
Echinococcus multilocularis neuropeptide s receptor 0.1672 0.1444 0.1444
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0006 0.0205
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0206 0.0161 0.5183
Onchocerca volvulus 0.006 0.0032 0.0279
Mycobacterium tuberculosis Possible penicillin-binding protein 0.2408 0.2088 0.7691
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0679 0.0574 0.2672
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0024 0.0108
Leishmania major cysteine peptidase A (CPA) 0.006 0.0032 0.1044
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0032 0.1033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0008
Brugia malayi RNA recognition motif domain containing protein 0.0196 0.0152 0.0703
Schistosoma mansoni cathepsin F (C01 family) 0.006 0.0032 0.0032
Toxoplasma gondii hypothetical protein 0.011 0.0076 0.2412
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0247 0.0196 0.0912
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.016 0.012 0.0556
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0228 0.0179 0.5782
Chlamydia trachomatis pyruvate kinase 0.0029 0.0005 0.0106
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0206 0.0161 0.1397
Mycobacterium ulcerans pyruvate kinase 0.0029 0.0005 0.001
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.011 0.0076 0.2412
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0002 0.0055
Loa Loa (eye worm) hypothetical protein 0.0465 0.0387 0.18
Echinococcus granulosus Niemann Pick C1 protein 0.0151 0.0112 0.0111
Brugia malayi hypothetical protein 0.0596 0.0502 0.2334
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0197 0.0153 0.0563
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0032 0.0008 0.0037
Schistosoma mansoni lipoxygenase 0.005 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0197 0.0152 0.0707
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0219 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0032 0.0279
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0044 0.0151
Mycobacterium ulcerans lipase LipD 0.0377 0.031 0.1133
Plasmodium vivax pyruvate kinase, putative 0.0029 0.0005 0.0109
Echinococcus granulosus polycomb protein SCMH1 0.014 0.0103 0.0102
Trichomonas vaginalis penicillin-binding protein, putative 0.0377 0.031 0.2699
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0754 0.064 0.064
Mycobacterium ulcerans transcriptional regulator 0.3124 0.2715 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0032 0.0008 0.0008
Plasmodium vivax vivapain-1 0.0031 0.0007 0.016
Schistosoma mansoni patched 1 0.0045 0.002 0.0019
Mycobacterium tuberculosis Probable lipase LipE 0.0377 0.031 0.1142
Leishmania major hypothetical protein, conserved 0.0377 0.031 1
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0032 0.0008 0.0037
Trichomonas vaginalis ap endonuclease, putative 0.0092 0.0061 0.0526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.002 0.0168
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0067 0.0038 0.124
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0024 0.0023
Onchocerca volvulus Pyruvate kinase homolog 0.0029 0.0005 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0006 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0032 0.0279
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0042 0.0017 0.0142
Loa Loa (eye worm) RNA binding protein 0.0196 0.0152 0.0703
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.0245 0.7899
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0001 0.0001
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.0056 0.1792
Echinococcus multilocularis lysosomal alpha glucosidase 0.0281 0.0226 0.0226
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0003 0.0012
Trichomonas vaginalis pyruvate kinase, putative 0.0029 0.0005 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0044 0.0201
Brugia malayi Inositol-1 0.0247 0.0196 0.091
Giardia lamblia PHD finger protein 15 0.0028 0.0005 0.0288
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0006 0.0023
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0002 0.0002
Echinococcus multilocularis cathepsin L cysteine protease 0.006 0.0032 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0228 0.0179 0.5782
Echinococcus multilocularis peregrin 0.0038 0.0013 0.0013
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0024 0.0023
Mycobacterium ulcerans AcrR family transcriptional regulator 0.3124 0.2715 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0003 0.0081
Loa Loa (eye worm) hypothetical protein 0.0185 0.0142 0.0658
Trichomonas vaginalis maltase-glucoamylase, putative 0.0062 0.0035 0.0298
Plasmodium vivax importin-beta 2, putative 0.0027 0.0003 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0228 0.0179 0.5782
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0024 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0019 0.0609
Echinococcus granulosus cyclins 0.0043 0.0018 0.0017
Trichomonas vaginalis cyclin B, putative 0.0043 0.0018 0.015
Schistosoma mansoni hypothetical protein 0.0028 0.0005 0.0004
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0002 0.0002
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0032 0.0008 0.0008
Onchocerca volvulus Cathepsin L homolog 0.006 0.0032 0.0279
Schistosoma mansoni hypothetical protein 0.1479 0.1275 0.1275
Schistosoma mansoni hypothetical protein 0.0044 0.0018 0.0018
Schistosoma mansoni coup transcription factor 0.005 0.0024 0.0023
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.003 0.0007 0.0207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0042 0.0017 0.0142
Loa Loa (eye worm) hypothetical protein 0.0206 0.0161 0.0746
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0028 0.0005 0.0004
Echinococcus granulosus GPCR family 2 0.0215 0.0168 0.0168
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0002 0.0008
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0024 0.0023
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0026 0.0003 0.0058
Brugia malayi mbt repeat family protein 0.014 0.0103 0.0477
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0032 0.1029
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.014 0.0103 0.0103
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0319 0.026 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0015 0.0068
Schistosoma mansoni inositol monophosphatase 0.0247 0.0196 0.0196
Brugia malayi latrophilin 2 splice variant baaae 0.0464 0.0386 0.1797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0005 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0044 0.0151
Echinococcus granulosus cathepsin l1 0.004 0.0015 0.0015
Trypanosoma brucei importin beta-1 subunit, putative 0.0027 0.0003 0.011
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0073 0.0044 0.0151
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0023 0.0195
Brugia malayi Calcitonin receptor-like protein seb-1 0.0679 0.0574 0.2672
Trypanosoma cruzi CYC2-like cyclin, putative 0.0043 0.0018 0.0556
Brugia malayi MAP kinase sur-1 0.0059 0.0032 0.0147
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0172 0.013 0.4164
Echinococcus multilocularis beta LACTamase domain containing family member 0.0377 0.031 0.031
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0023 0.0673
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0032 0.0008 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0019 0.0609
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0032 0.0279
Echinococcus granulosus cyclin B3 1 0.0043 0.0018 0.0017
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0024 0.0023
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.0245 0.7896
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0092 0.0061 0.1948
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0007 0.0159
Loa Loa (eye worm) histone methyltransferase 0.0063 0.0035 0.0163
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0006 0.0052
Loa Loa (eye worm) hypothetical protein 0.016 0.012 0.0556
Loa Loa (eye worm) hypothetical protein 0.0133 0.0096 0.0446
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.014 0.0103 0.0893
Trichomonas vaginalis sucrase-isomaltase, putative 0.0062 0.0035 0.0298
Brugia malayi intermediate filament protein 0.0131 0.0095 0.0441
Brugia malayi beta-lactamase family protein 0.0377 0.031 0.1441
Trypanosoma cruzi cysteine protease, putative 0.0031 0.0007 0.0214
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0043 0.0018 0.0569
Loa Loa (eye worm) fibroinase 0.006 0.0032 0.0149
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0219 0.0172 0.0634
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0247 0.0196 0.0712
Trichomonas vaginalis cyclin B, putative 0.0043 0.0018 0.015
Brugia malayi nuclear receptor RXR 0.0023 0.0001 0.0001
Giardia lamblia Hypothetical protein 0.0043 0.0018 0.1097
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0032 0.0008 0.0008
Trichomonas vaginalis cyclins, putative 0.0043 0.0018 0.015
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0281 0.0226 0.1049
Onchocerca volvulus 0.006 0.0032 0.0279
Echinococcus granulosus lysosomal alpha glucosidase 0.0281 0.0226 0.0225
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0032 0.0275
Trypanosoma brucei importin beta-1 subunit, putative 0.0027 0.0003 0.011
Echinococcus multilocularis thioredoxin glutathione reductase 0.0087 0.0056 0.0056
Trypanosoma cruzi cyclin, putative 0.0043 0.0018 0.0556
Brugia malayi MH2 domain containing protein 0.0979 0.0837 0.3895
Loa Loa (eye worm) hypothetical protein 0.0377 0.031 0.1441
Echinococcus multilocularis lamin 0.0131 0.0095 0.0095
Plasmodium vivax SET domain protein, putative 0.0172 0.013 0.4164
Trypanosoma cruzi target of rapamycin kinase 3 0.0067 0.0038 0.1228
Echinococcus granulosus zinc finger protein 0.0068 0.004 0.0039
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0006 0.0138
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0037
Trichomonas vaginalis inositol monophosphatase, putative 0.0247 0.0196 0.1704
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.008
Schistosoma mansoni jumonji/arid domain-containing protein 0.011 0.0076 0.0076
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0131 0.0095 0.0441
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0092 0.0061 0.2147
Schistosoma mansoni aldehyde dehydrogenase 0.0169 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0215 0.0168 0.0168
Toxoplasma gondii hypothetical protein 0.0026 0.0003 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0247 0.0196 0.4861
Echinococcus granulosus cyclins 0.0043 0.0018 0.0017
Plasmodium falciparum thioredoxin reductase 0.0087 0.0056 0.2089
Brugia malayi Glycosyl hydrolases family 31 protein 0.0281 0.0226 0.1049
Schistosoma mansoni hypothetical protein 0.0057 0.003 0.003
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0026 0.0003 0.0003
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0044 0.0161
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0032 0.0008 0.007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0011
Brugia malayi TAR-binding protein 0.0196 0.0152 0.0703
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0007 0.0007
Brugia malayi cytoplasmic intermediate filament protein 0.007 0.0042 0.0192
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0197 0.0153 0.0554
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0219 0.0172 0.0172
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.005 0.0024 0.0023
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0084 0.0053 0.171
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0152 0.0151
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0003 0.0068
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0032 0.0008 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0002 0.0008
Loa Loa (eye worm) intermediate filament protein 0.0131 0.0095 0.0441
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.006 0.0032 0.0149
Trichomonas vaginalis inositol monophosphatase, putative 0.0026 0.0003 0.002
Loa Loa (eye worm) hypothetical protein 0.0596 0.0502 0.2334
Echinococcus granulosus mothers against decapentaplegic 2 0.003 0.0006 0.0006
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0032 0.0008 0.0037
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0032 0.0008 0.0008
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0073 0.0044 0.0151
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0005 0.0004
Echinococcus multilocularis protein patched 0.0045 0.002 0.002
Onchocerca volvulus Huntingtin homolog 0.0596 0.0502 0.4372
Echinococcus granulosus lamin 0.0131 0.0095 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0035 0.0298
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0206 0.0161 0.016
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0026 0.0003 0.0088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0032 0.0279
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0007 0.0227
Toxoplasma gondii cathepsin CPL 0.006 0.0032 0.0983
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0754 0.064 0.2977
Mycobacterium tuberculosis Probable lipase LipD 0.0377 0.031 0.1142
Loa Loa (eye worm) papain family cysteine protease containing protein 0.006 0.0032 0.0149
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0209 0.0163 0.0601
Trichomonas vaginalis cyclins, putative 0.0043 0.0018 0.015
Echinococcus multilocularis expressed protein 0.0031 0.0007 0.0007
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0206 0.0161 0.016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0228 0.0179 0.5782
Plasmodium falciparum cysteine proteinase falcipain 2b 0.006 0.0032 0.1176
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0108
Echinococcus granulosus TGF beta signal transducer SmadC 0.0067 0.0039 0.0038
Loa Loa (eye worm) cyclin domain-containing protein 0.0043 0.0018 0.008
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.0245 0.7899
Trichomonas vaginalis cyclin B, putative 0.0043 0.0018 0.015
Giardia lamblia Hypothetical protein 0.0026 0.0003 0.017
Trichomonas vaginalis ap endonuclease, putative 0.0092 0.0061 0.0526
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0754 0.064 0.064
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0002 0.0002
Onchocerca volvulus 0.0026 0.0003 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.002 0.0168
Leishmania major myo-inositol-1 phosphatase, putative 0.0026 0.0003 0.0088
Loa Loa (eye worm) hypothetical protein 0.0055 0.0029 0.0131
Echinococcus multilocularis cyclins 0.0043 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0206 0.0161 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0007 0.0058
Trypanosoma brucei unspecified product 0.0037 0.0013 0.0408
Echinococcus granulosus Protein patched homolog 1 0.0045 0.002 0.0019
Echinococcus granulosus methyl CpG binding domain protein 2 0.0047 0.0022 0.0021
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0002 0.0055
Schistosoma mansoni cellular tumor antigen P53 0.0462 0.0385 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0035 0.0298
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0032 0.0008 0.0037
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0185 0.0142 0.0522
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0032 0.0008 0.007
Echinococcus multilocularis GPCR, family 2 0.0215 0.0168 0.0168
Toxoplasma gondii aldehyde dehydrogenase 0.0169 0.0128 0.4104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0032 0.0279
Loa Loa (eye worm) MH2 domain-containing protein 0.0067 0.0039 0.0177
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0044 0.0151
Echinococcus multilocularis tar DNA binding protein 0.0196 0.0152 0.0151
Echinococcus granulosus FTZ F1 alpha 0.005 0.0024 0.0023
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0014 0.0461
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0024 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0754 0.064 0.064
Schistosoma mansoni smad1 5 8 and 0.0067 0.0039 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0017 0.0142
Echinococcus multilocularis neuropeptide receptor A26 0.1672 0.1444 0.1444
Schistosoma mansoni hypothetical protein 0.0034 0.001 0.001
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0007 0.0164
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0017 0.0559
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0215 0.0168 0.0168
Entamoeba histolytica cysteine protease, putative 0.0031 0.0007 0.0164
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0006 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0038 0.0331
Toxoplasma gondii hypothetical protein 0.0049 0.0023 0.0673
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0247 0.0196 0.0714
Brugia malayi Importin beta-1 subunit 0.0027 0.0003 0.0014
Trichomonas vaginalis cyclin B, putative 0.0043 0.0018 0.015
Trichomonas vaginalis D-aminoacylase, putative 0.0377 0.031 0.2699
Loa Loa (eye worm) hypothetical protein 0.0064 0.0036 0.0167
Mycobacterium ulcerans acyl-CoA synthetase 0.0247 0.0196 0.0714
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0023 0.0195
Brugia malayi nuclear hormone receptor 0.0023 0.0001 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0006 0.0027
Brugia malayi Pyruvate kinase, muscle isozyme 0.0029 0.0005 0.0023
Onchocerca volvulus 0.006 0.0032 0.0279
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0206 0.0161 0.1397
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0024 0.0023
Echinococcus granulosus cyclins 0.0043 0.0018 0.0017
Trypanosoma cruzi pyruvate kinase 2, putative 0.0029 0.0005 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0019 0.0609
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0092 0.0061 0.1496
Echinococcus multilocularis cathepsin L cysteine protease 0.006 0.0032 0.0032
Toxoplasma gondii hypothetical protein 0.0033 0.0009 0.021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0365 0.03 0.9669
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0172 0.013 0.013
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0092 0.0061 0.1958
Echinococcus multilocularis musashi 0.0131 0.0095 0.0095
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0006 0.0142
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.0072 0.0072
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0073 0.0044 0.0161
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0152 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0032 0.0279
Schistosoma mansoni nuclear hormone receptor 0.005 0.0024 0.0023
Entamoeba histolytica G protein alpha subunit, putative 0.0032 0.0008 0.02
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0044 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0032 0.0279
Mycobacterium ulcerans acyl-CoA synthetase 0.0247 0.0196 0.0714
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0006 0.0193
Brugia malayi beta-lactamase 0.0377 0.031 0.1441
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0028 0.0005 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0006 0.0193
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Trypanosoma brucei pyruvate kinase 1 0.0029 0.0005 0.0176
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0175 0.0133 0.049
Plasmodium falciparum glutathione reductase 0.0087 0.0056 0.2089
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0046 0.1724
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0319 0.026 0.0947
Loa Loa (eye worm) G protein alpha subunit 3 0.0032 0.0008 0.0037
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0032 0.0032
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0044 0.0161
Schistosoma mansoni myst-related protein 0.0027 0.0004 0.0003
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.003 0.0007 0.0207
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0175 0.0133 0.049
Echinococcus granulosus arachidonate 5 lipoxygenase 0.005 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.008
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0857 0.073 0.3398
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0206 0.0161 0.016
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0032 0.0008 0.0008
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0028 0.0005 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0161 0.1397
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0032 0.0275
Trypanosoma brucei glucosidase, putative 0.0062 0.0035 0.1116
Trypanosoma cruzi hypothetical protein, conserved 0.0377 0.031 1
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0015 0.0364
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0044 0.0151
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0073 0.0044 0.0151
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0046 0.1724
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0084 0.0053 0.1721
Loa Loa (eye worm) nuclear receptor NHR-67 0.0023 0.0001 0.0001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0377 0.031 0.1142
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.002 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0032 0.0279
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0041 0.0016 0.0015
Onchocerca volvulus 0.0377 0.031 0.2699
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0073 0.0044 0.0201
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0005 0.0082
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.01 0.0068 0.0067
Entamoeba histolytica cysteine proteinase, putative 0.006 0.0032 0.0793
Entamoeba histolytica cysteine protease, putative 0.006 0.0032 0.0793
Loa Loa (eye worm) hypothetical protein 0.0377 0.031 0.1441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0032 0.0279
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0505 0.0422 0.1964
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0035 0.1104
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0319 0.026 0.0947
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0019 0.0609
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0005 0.0023
Plasmodium falciparum importin beta, putative 0.0027 0.0003 0.005
Brugia malayi polk-prov protein 0.0034 0.0009 0.0042
Echinococcus multilocularis cathepsin l cysteine peptidase 0.006 0.0032 0.0032
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0026 0.0003 0.0088
Onchocerca volvulus 0.0043 0.0018 0.015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0169 0.0128 0.0464
Plasmodium vivax vivapain-2 0.006 0.0032 0.0983
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.011 0.0076 0.2885
Trypanosoma brucei hypothetical protein, conserved 0.0377 0.031 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0073 0.0044 0.1348
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0063 0.0035 0.0035
Leishmania major 4-coumarate:coa ligase-like protein 0.0247 0.0196 0.6335
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0197 0.0153 0.0563
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0032 0.0008 0.0008
Brugia malayi Muscleblind-like protein 0.0465 0.0387 0.18
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0247 0.0196 0.0714
Loa Loa (eye worm) hypothetical protein 0.0029 0.0005 0.0023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0247 0.0196 0.4861
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0032 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.002 0.0167
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.001 0.0009
Echinococcus granulosus cathepsin l cysteine peptidase 0.006 0.0032 0.0032
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0063 0.0035 0.0035
Echinococcus granulosus pyruvate kinase 0.0029 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.002 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0017 0.0142
Schistosoma mansoni smad1 5 8 and 0.0067 0.0039 0.0038
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0002 0.0002
Schistosoma mansoni inositol monophosphatase 0.0247 0.0196 0.0196
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0028 0.0005 0.0004
Schistosoma mansoni pap-inositol-14-phosphatase 0.0026 0.0003 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0247 0.0196 0.0912
Loa Loa (eye worm) hypothetical protein 0.0117 0.0082 0.0382
Loa Loa (eye worm) acetyltransferase 0.015 0.0112 0.0517
Schistosoma mansoni hypothetical protein 0.1534 0.1323 0.1323
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0032 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0024 0.0108
Plasmodium falciparum cysteine proteinase falcipain 2a 0.006 0.0032 0.1176
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0037
Loa Loa (eye worm) hypothetical protein 0.0061 0.0034 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0032 0.0279
Onchocerca volvulus 0.014 0.0103 0.0893
Brugia malayi ecdysone receptor 0.0023 0.0001 0.0001
Brugia malayi Latrophilin receptor protein 2 0.0215 0.0168 0.0781
Echinococcus granulosus cysteine protease 0.0031 0.0007 0.0006
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0092 0.0061 0.0224
Echinococcus granulosus inositol monophosphatase 1 0.0247 0.0196 0.0195
Schistosoma mansoni hypothetical protein 0.1534 0.1323 0.1323
Echinococcus granulosus expressed protein 0.0031 0.0007 0.0007
Echinococcus multilocularis mothers against decapentaplegic 5 0.0067 0.0039 0.0038
Echinococcus granulosus cathepsin L cysteine proteinase 0.006 0.0032 0.0032
Trichomonas vaginalis antibiotic synthetase, putative 0.0073 0.0044 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0023 0.0201
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0053 0.0462
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0084 0.0053 0.171
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0032 0.0008 0.0008
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0019 0.0609
Trypanosoma cruzi ISWI complex protein 0.0043 0.0017 0.0548
Echinococcus granulosus mixed lineage leukemia protein mll 0.0052 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0129 0.0093 0.0431
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0032 0.0008 0.0008
Onchocerca volvulus 0.006 0.0032 0.0279
Entamoeba histolytica cyclin family protein 0.0043 0.0018 0.0427
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0206 0.0161 0.0746
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0073 0.0044 0.1072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0034 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0024 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0009 0.0305
Trichomonas vaginalis cyclin D, putative 0.0043 0.0018 0.015
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0031 0.0007 0.0214
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0152 0.0151
Schistosoma mansoni Smad4 0.003 0.0006 0.0006
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0032 0.0008 0.0037
Mycobacterium ulcerans aldehyde dehydrogenase 0.0169 0.0128 0.0464
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0044 0.0161
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0006 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0038 0.0331
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0019 0.0609
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0019 0.0609
Schistosoma mansoni cpg binding protein 0.02 0.0155 0.0155
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0024 0.0202
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0032 0.0008 0.007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0024 0.0023
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0247 0.0196 0.1704
Trichomonas vaginalis alpha-glucosidase, putative 0.0062 0.0035 0.0298
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0073 0.0044 0.0161
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0377 0.031 0.031
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0032 0.0008 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0247 0.0196 0.0714
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0038 0.0331
Echinococcus multilocularis cysteine protease 0.006 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0061 0.0034 0.0154
Entamoeba histolytica acyl-coA synthetase, putative 0.0247 0.0196 0.4861
Schistosoma mansoni lamin 0.0131 0.0095 0.0095
Schistosoma mansoni acetyl-CoA synthetase 0.0073 0.0044 0.0043
Onchocerca volvulus 0.0377 0.031 0.2699
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0043 0.0018 0.0017
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0005 0.0082
Entamoeba histolytica cysteine protease, putative 0.0031 0.0007 0.0164
Schistosoma mansoni cyclin B 0.0043 0.0018 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0044 0.0151
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0067 0.0039 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0228 0.0179 0.5782
Onchocerca volvulus 0.0023 0.0001 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0019 0.0596
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0062 0.0035 0.1055
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0024 0.0023
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0026 0.0003 0.0058
Loa Loa (eye worm) DR-78 0.0023 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0185 0.0142 0.0658
Schistosoma mansoni hypothetical protein 0.0128 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0108
Echinococcus granulosus SAM and MBT domain containing protein 0.014 0.0103 0.0102
Echinococcus granulosus cyclins 0.0043 0.0018 0.0017
Echinococcus multilocularis pyruvate kinase 0.0029 0.0005 0.0005
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0032 0.0008 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0019 0.006
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0073 0.0044 0.0151
Mycobacterium tuberculosis Probable oxidoreductase 0.0262 0.0209 0.077
Schistosoma mansoni transcription factor LCR-F1 0.0484 0.0404 0.0403
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0319 0.026 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0571 0.048 0.048
Onchocerca volvulus 0.0032 0.0008 0.007
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0023 0.0673
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.004 0.0015 0.0476
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0006 0.0205
Onchocerca volvulus Pyruvate kinase homolog 0.0029 0.0005 0.0044
Loa Loa (eye worm) oxidoreductase 0.0073 0.0044 0.0201
Echinococcus granulosus peregrin 0.0038 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0003 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0024 0.0023
Brugia malayi SET domain containing protein 0.0026 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.2477 0.2149 1
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0019 0.006
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0007 0.0031
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0062 0.0035 0.0159
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0024 0.0202
Brugia malayi Bromodomain containing protein 0.0223 0.0175 0.0813
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0032 0.0032
Plasmodium falciparum cysteine proteinase falcipain 3 0.006 0.0032 0.1176
Echinococcus granulosus intermediate filament protein 0.0131 0.0095 0.0095
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0003 0.0012
Brugia malayi MH2 domain containing protein 0.0067 0.0039 0.0177
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0006 0.0028
Loa Loa (eye worm) hypothetical protein 0.0462 0.0385 0.1789
Echinococcus multilocularis lysine specific demethylase 5A 0.0094 0.0063 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0017 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0032 0.0279
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.0003 0.0003
Brugia malayi jmjC domain containing protein 0.0025 0.0002 0.0008
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0006 0.0205
Brugia malayi hypothetical protein 0.0026 0.0003 0.0012
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0024 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0029 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0032 0.0279
Loa Loa (eye worm) hypothetical protein 0.0377 0.031 0.1441
Brugia malayi CXXC zinc finger family protein 0.0184 0.0141 0.0656
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0032 0.0275
Brugia malayi MH1 domain containing protein 0.0067 0.0039 0.0177
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0032 0.0008 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0152 0.0151
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0247 0.0196 0.0714
Brugia malayi jmjC domain containing protein 0.0025 0.0002 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0044 0.0151
Echinococcus granulosus snurportin 1 0.0284 0.0229 0.0228
Schistosoma mansoni myst-related protein 0.0027 0.0004 0.0003
Echinococcus granulosus cyclin b3 0.0043 0.0018 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0015 0.0128
Schistosoma mansoni pyruvate kinase 0.0029 0.0005 0.0005
Echinococcus granulosus cyclin B 0.0043 0.0018 0.0017
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0221 0.0173 0.0638
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0032 0.0008 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0035 0.0298
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0032 0.0968
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0007 0.0007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0754 0.064 0.2977
Loa Loa (eye worm) hypothetical protein 0.046 0.0383 0.1781
Schistosoma mansoni cpg binding protein 0.0184 0.0141 0.0141
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0377 0.031 0.1441
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0024 0.0108
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0006 0.0006
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0247 0.0196 0.632
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0397 0.0328 0.0327
Trichomonas vaginalis rotamase, putative 0.003 0.0007 0.0056
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0319 0.026 0.0947
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0005 0.002
Echinococcus granulosus survival motor neuron protein 1 0.2477 0.2149 0.2148
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0023 0.0673
Echinococcus granulosus tar DNA binding protein 0.0196 0.0152 0.0151
Brugia malayi hypothetical protein 0.046 0.0383 0.1781
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0006 0.0193
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0006 0.0013
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0003 0.0081
Echinococcus multilocularis cathepsin l cysteine peptidase 0.006 0.0032 0.0032
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0319 0.026 1
Giardia lamblia Pyruvate kinase 0.0029 0.0005 0.0339
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0007 0.0058
Loa Loa (eye worm) hypothetical protein 0.0247 0.0196 0.0912
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0001 0.0002
Echinococcus multilocularis cyclin B 0.0043 0.0018 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0009 0.0305
Brugia malayi Flap endonuclease-1 0.0026 0.0003 0.001
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0003 0.0156
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0377 0.031 0.1142
Plasmodium vivax vivapain-3 0.0031 0.0007 0.016
Brugia malayi jmjC domain containing protein 0.011 0.0076 0.0354
Loa Loa (eye worm) hypothetical protein 0.0596 0.0502 0.2334
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0024 0.0108
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0023 0.0001 0.0001
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.0003 0.0002
Trichomonas vaginalis cyclin B3, putative 0.0043 0.0018 0.015
Onchocerca volvulus 0.0073 0.0044 0.0377
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0073 0.0044 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0005 0.0082
Brugia malayi mothers against decapentaplegic homolog 3 0.003 0.0006 0.0027
Loa Loa (eye worm) thioredoxin reductase 0.0087 0.0056 0.0258
Brugia malayi jmjC domain containing protein 0.0025 0.0002 0.0008
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0062 0.0035 0.0298
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0026 0.0003 0.002
Entamoeba histolytica cysteine protease, putative 0.0031 0.0007 0.0164
Trichomonas vaginalis set domain proteins, putative 0.1334 0.1148 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.0005 0.002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0024 0.0023
Echinococcus granulosus muscleblind protein 0.0465 0.0387 0.0387
Loa Loa (eye worm) ctsf protein 0.006 0.0032 0.0149
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0007 0.0164
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0131 0.0095 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0005 0.0037
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.002 0.0019
Brugia malayi nuclear hormone receptor family member nhr-6 0.0023 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.006 0.0032 0.1044
Echinococcus granulosus neuropeptide s receptor 0.1672 0.1444 0.1444
Brugia malayi tailless protein 0.0023 0.0001 0.0001
Trypanosoma brucei ISWI complex protein 0.0043 0.0017 0.0561
Brugia malayi ecdysteroid receptor 0.005 0.0024 0.0108
Echinococcus multilocularis inositol monophosphatase 1 0.0247 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Schistosoma mansoni bromodomain containing protein 0.0026 0.0003 0.0002
Schistosoma mansoni aldehyde dehydrogenase 0.0169 0.0128 0.0128
Plasmodium falciparum zinc finger protein, putative 0.0027 0.0004 0.0065
Brugia malayi Inositol monophosphatase family protein 0.0026 0.0003 0.0011
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.016 0.012 0.0119
Leishmania major hypothetical protein, conserved 0.0025 0.0002 0.0068
Entamoeba histolytica cyclin, putative 0.0043 0.0018 0.0427
Echinococcus multilocularis inositol monophosphatase 0.0026 0.0003 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0044 0.0201
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0092 0.0061 0.2277
Mycobacterium leprae conserved hypothetical protein 0.0377 0.031 0.1133
Schistosoma mansoni survival motor neuron protein 0.0505 0.0422 0.0422
Schistosoma mansoni cathepsin F (C01 family) 0.006 0.0032 0.0032
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0026 0.0003 0.0075
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0067 0.0038 0.124
Trichomonas vaginalis cyclin B, putative 0.0043 0.0018 0.015
Echinococcus granulosus geminin 0.1534 0.1323 0.1323
Schistosoma mansoni cpg binding protein 0.02 0.0155 0.0155
Entamoeba histolytica hypothetical protein 0.0484 0.0404 1
Brugia malayi Cathepsin L-like precursor 0.006 0.0032 0.0149
Schistosoma mansoni jumonji/arid domain-containing protein 0.011 0.0076 0.0076
Schistosoma mansoni methyl-cpg binding protein mbd 0.0047 0.0022 0.0021
Onchocerca volvulus 0.006 0.0032 0.0279
Leishmania major hypothetical protein, conserved 0.0076 0.0046 0.1499
Schistosoma mansoni hypothetical protein 0.0871 0.0743 0.0743
Schistosoma mansoni alpha glucosidase 0.0062 0.0035 0.0034
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0006 0.0205
Loa Loa (eye worm) hypothetical protein 0.0377 0.031 0.1441
Loa Loa (eye worm) MBCTL1 0.016 0.012 0.0556
Schistosoma mansoni hypothetical protein 0.0505 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.006 0.0032 0.0149
Echinococcus granulosus tumor protein p63 0.3158 0.2745 0.2745
Schistosoma mansoni ap endonuclease 0.0092 0.0061 0.006
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.3124 0.2715 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0073 0.0044 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0024 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0007 0.0061
Schistosoma mansoni GTP-binding protein alpha subunit 0.0032 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0044 0.0018 0.0018
Plasmodium falciparum thioredoxin reductase 0.003 0.0006 0.0165
Echinococcus granulosus neutral alpha glucosidase AB 0.0062 0.0035 0.0034
Plasmodium vivax unspecified product 0.0031 0.0007 0.016
Echinococcus granulosus smad 0.0067 0.0039 0.0038
Schistosoma mansoni cyclin B3 0.0043 0.0018 0.0017
Echinococcus granulosus mothers against decapentaplegic 5 0.0067 0.0039 0.0038
Brugia malayi Intermediate filament tail domain containing protein 0.0131 0.0095 0.0441
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0006 0.0165
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0484 0.0404 0.0403
Mycobacterium tuberculosis Conserved protein 0.0377 0.031 0.1142
Mycobacterium tuberculosis Conserved protein 0.0377 0.031 0.1142
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0019 0.0161
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0006 0.0193
Brugia malayi jmjC domain containing protein 0.0025 0.0002 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0035 0.1104
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0044 0.0151
Leishmania major cyclin 0.0043 0.0018 0.0569
Echinococcus granulosus lysine specific demethylase 5A 0.011 0.0076 0.0076
Echinococcus multilocularis polycomb protein SCMH1 0.014 0.0103 0.0103
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0052 0.0026 0.0025
Brugia malayi Cathepsin L-like precursor 0.006 0.0032 0.0149
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0102 0.0102
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0206 0.0161 1
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0032 0.0008 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0044 0.0151
Loa Loa (eye worm) hypothetical protein 0.0034 0.0009 0.0042
Trypanosoma brucei protein kinase, putative 0.0059 0.0032 0.1029
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0032 0.1029
Loa Loa (eye worm) hypothetical protein 0.0073 0.0044 0.0201
Loa Loa (eye worm) hypothetical protein 0.0028 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0011
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0073 0.0044 0.0151
Schistosoma mansoni cyclins 0.0043 0.0018 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.002 0.0168
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0006 0.0013
Brugia malayi CHE-14 protein 0.0045 0.002 0.009
Onchocerca volvulus Alhambra homolog 0.0028 0.0005 0.0037
Echinococcus multilocularis cpg binding protein 0.02 0.0155 0.0155
Brugia malayi Cathepsin L-like precursor 0.004 0.0015 0.0068
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0073 0.0044 0.1395
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0044 0.0151
Plasmodium falciparum cyclin 0.0043 0.0018 0.0603
Echinococcus multilocularis cyclin B3 1 0.0043 0.0018 0.0018
Mycobacterium ulcerans esterase/lipase LipP 0.0377 0.031 0.1133
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0017 0.0142
Brugia malayi nuclear receptor RXR 0.0026 0.0003 0.0012
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0006 0.0165
Onchocerca volvulus 0.005 0.0024 0.0202
Echinococcus multilocularis cyclins 0.0043 0.0018 0.0018
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0007 0.0214
Onchocerca volvulus Cathepsin L homolog 0.006 0.0032 0.0279
Onchocerca volvulus 0.0184 0.0141 0.1229
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0067 0.0039 0.0038
Entamoeba histolytica cyclin, putative 0.0043 0.0018 0.0427
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0024 0.0023
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0084 0.0053 0.0053
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0092 0.0061 0.3779
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0073 0.0044 0.1407
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0031 0.0141
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.0003 0.0003
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0003 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0215 0.0168 0.0168
Brugia malayi MH1 domain containing protein 0.0037 0.0012 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0024 0.0108
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0032 0.0008 0.0008
Brugia malayi hypothetical protein 0.0026 0.0003 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0017 0.0142
Brugia malayi Bromodomain containing protein 0.011 0.0076 0.0354
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0002 0.0002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0042 0.0017 0.0142
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0044 0.0201
Echinococcus multilocularis survival motor neuron protein 1 0.2477 0.2149 0.2149
Trypanosoma cruzi cysteine peptidase, putative 0.0228 0.0179 0.5777
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0215 0.0168 0.0168
Trypanosoma cruzi cyclin 6, putative 0.0043 0.0018 0.0556
Entamoeba histolytica cysteine protease, putative 0.0031 0.0007 0.0164
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0084 0.0053 0.1313
Schistosoma mansoni SET domain protein 0.0026 0.0003 0.0003
Leishmania major alpha glucosidase II subunit, putative 0.0062 0.0035 0.1116
Echinococcus multilocularis microtubule associated protein 2 1.1446 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0062 0.0035 0.0298
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0028 0.0005 0.0151
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0028 0.0005 0.0151
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0046 0.1499
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0247 0.0196 0.0714
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0754 0.064 0.064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0228 0.0179 0.5782
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0014 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0175 0.0133 0.049
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0014 0.0014
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0319 0.026 1
Echinococcus granulosus neuropeptide receptor A26 0.1672 0.1444 0.1444
Echinococcus multilocularis neutral alpha glucosidase AB 0.0062 0.0035 0.0034
Trichomonas vaginalis helicase, putative 0.0042 0.0017 0.0142
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0019 0.0609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0247 0.0196 0.0723
Echinococcus granulosus inositol monophosphatase 0.0026 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0464 0.0386 0.1797
Loa Loa (eye worm) hypothetical protein 0.0465 0.0387 0.18
Entamoeba histolytica cysteine protease, putative 0.0031 0.0007 0.0164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0754 0.064 0.0639
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0024 0.0108
Schistosoma mansoni hypothetical protein 0.0215 0.0168 0.0168
Schistosoma mansoni alpha-glucosidase 0.0241 0.0192 0.0191
Schistosoma mansoni hypothetical protein 0.0484 0.0404 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0024 0.0108
Leishmania major hypothetical protein, conserved 0.0043 0.0017 0.0561
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.016 0.012 0.012
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.002 0.009
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0219 0.0172 0.0625
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0003 0.0013
Schistosoma mansoni zinc finger protein 0.0043 0.0017 0.0017
Loa Loa (eye worm) beta-lactamase 0.0377 0.031 0.1441
Loa Loa (eye worm) hypothetical protein 0.0073 0.0044 0.0201
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0206 0.0161 0.5176
Brugia malayi nuclear receptor NHR-88 0.005 0.0024 0.0108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0042 0.0017 0.0142
Trypanosoma cruzi pyruvate kinase 2, putative 0.0029 0.0005 0.0163
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0073 0.0044 0.0161
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0032 0.0008 0.007
Echinococcus multilocularis cathepsin L 0.0031 0.0007 0.0007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0024 0.0023
Trypanosoma brucei pyruvate kinase 1, putative 0.0029 0.0005 0.0176
Onchocerca volvulus 0.1334 0.1148 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0035 0.0298
Entamoeba histolytica cysteine protease, putative 0.0031 0.0007 0.0164
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0044 0.0151
Mycobacterium tuberculosis Probable esterase LipL 0.0377 0.031 0.1142
Entamoeba histolytica cysteine proteinase, putative 0.006 0.0032 0.0793
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0092 0.0061 0.0281
Brugia malayi Bromodomain containing protein 0.0038 0.0013 0.0061
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0247 0.0196 0.1704
Entamoeba histolytica cysteine protease, putative 0.0031 0.0007 0.0164
Brugia malayi F/Y-rich N-terminus family protein 0.0077 0.0047 0.0219
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0006 0.0205
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0219 0.0172 0.0172
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0206 0.0161 0.3975
Giardia lamblia GTOR 0.0084 0.0053 0.3321
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0032 0.0008 0.0037
Brugia malayi MH2 domain containing protein 0.0067 0.0039 0.0177
Trichomonas vaginalis esterase, putative 0.0377 0.031 0.2699
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0185 0.0142 0.5413
Entamoeba histolytica cyclin family protein 0.0043 0.0018 0.0427
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0006 0.0193
Brugia malayi Cathepsin L-like cysteine proteinase 0.004 0.0015 0.0068
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0032 0.0008 0.0008
Trypanosoma cruzi cysteine peptidase, putative 0.0228 0.0179 0.5777
Leishmania major cathepsin L-like protease 0.006 0.0032 0.1044
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.0093 0.0092
Brugia malayi steroid hormone receptor 0.005 0.0024 0.0108
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0084 0.0053 0.0246
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0006 0.0205
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0011
Brugia malayi G-protein alpha subunit 0.0032 0.0008 0.0037
Schistosoma mansoni microtubule-associated protein tau 1.1446 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0032 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0005 0.0037
Schistosoma mansoni lamin 0.0131 0.0095 0.0095
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0062 0.0035 0.0128
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.012 0.044
Loa Loa (eye worm) hypothetical protein 0.0107 0.0074 0.0341
Leishmania major cathepsin L-like protease 0.006 0.0032 0.1044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0032 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0023 0.0201
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0003 0.0003
Brugia malayi Cathepsin L-like precursor 0.004 0.0015 0.0068
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0247 0.0196 0.0912
Brugia malayi beta-lactamase family protein 0.0377 0.031 0.1441
Brugia malayi Pre-SET motif family protein 0.1172 0.1006 0.4682
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0006 0.0193
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.003 0.0007 0.022
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0024 0.0108
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0073 0.0044 0.0151
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0197 0.0153 0.0563
Mycobacterium ulcerans short chain dehydrogenase 0.0262 0.0209 0.0761
Schistosoma mansoni smad 0.0067 0.0039 0.0038
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0014 0.087
Plasmodium falciparum phd finger protein, putative 0.0028 0.0005 0.0098
Plasmodium vivax vivapain-2 0.006 0.0032 0.0983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0035 0.0298
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0032 0.1017
Loa Loa (eye worm) hypothetical protein 0.0185 0.0142 0.0658
Entamoeba histolytica cysteine proteinase 2 0.0031 0.0007 0.0164
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0024 0.0108
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0108
Plasmodium falciparum cysteine proteinase falcipain 1 0.0031 0.0007 0.0192
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.011 0.0076 0.0272
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0062 0.0035 0.0848
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0019 0.0609
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.011 0.0076 0.2765
Schistosoma mansoni thyroid hormone receptor 0.0178 0.0136 0.0136
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0031 0.0007 0.0033
Trichomonas vaginalis alpha-glucosidase, putative 0.0062 0.0035 0.0298
Onchocerca volvulus 0.0023 0.0001 0.0002
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0196 0.0152 0.0703
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0026 0.0003 0.0088
Brugia malayi MH1 domain containing protein 0.0067 0.0039 0.0177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0032 0.0279
Loa Loa (eye worm) jmjC domain-containing protein 0.011 0.0076 0.0354
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0206 0.0161 0.5183
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0247 0.0196 0.7488
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0172 0.013 0.013
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0073 0.0044 0.0151
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0056
Schistosoma mansoni hypothetical protein 0.0026 0.0003 0.0002
Echinococcus granulosus pyruvate kinase 0.0029 0.0005 0.0005
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0031 0.0007 0.0033
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0209 0.0163 0.0601
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0005 0.0023
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0084 0.0053 0.1721
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.0072 0.1785
Schistosoma mansoni smad1 5 8 and 0.0067 0.0039 0.0038
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0247 0.0196 0.0912
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0219 0.0172 0.0634
Trypanosoma cruzi major cysteine proteinase, putative 0.0179 0.0137 0.44
Loa Loa (eye worm) hypothetical protein 0.0105 0.0072 0.0335
Loa Loa (eye worm) bromodomain containing protein 0.0053 0.0026 0.012
Schistosoma mansoni methyl-cpg binding protein mbd 0.0047 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0108
Echinococcus granulosus flap endonuclease 1 0.0026 0.0003 0.0002
Toxoplasma gondii HEAT repeat-containing protein 0.0027 0.0003 0.0042
Brugia malayi hypothetical protein 0.0049 0.0023 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0032 0.0279
Trichomonas vaginalis cyclins, putative 0.0043 0.0018 0.015
Echinococcus multilocularis Niemann Pick C1 protein 0.0151 0.0112 0.0112
Giardia lamblia Cyclin A 0.0043 0.0018 0.1097
Giardia lamblia G2/mitotic-specific cyclin B 0.0043 0.0018 0.1097
Mycobacterium tuberculosis Probable dehydrogenase 0.0197 0.0153 0.0563
Onchocerca volvulus 0.046 0.0383 0.3334
Echinococcus multilocularis cyclins 0.0043 0.0018 0.0018
Schistosoma mansoni jumonji domain containing protein 0.0133 0.0097 0.0096
Brugia malayi hypothetical protein 0.0023 0.0001 0.0001
Leishmania major trypanothione reductase 0.0087 0.0056 0.1802
Loa Loa (eye worm) CXXC zinc finger family protein 0.0184 0.0141 0.0656
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0215 0.0168 0.0168
Brugia malayi follicle stimulating hormone receptor 0.0857 0.073 0.3398
Mycobacterium ulcerans beta-lactamase 0.0377 0.031 0.1133
Schistosoma mansoni rotamase 0.0031 0.0007 0.0007
Echinococcus multilocularis protein dispatched 1 0.0052 0.0025 0.0025
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0084 0.0053 0.1721
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0042 0.0017 0.0142
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0029 0.0005 0.0155
Schistosoma mansoni hypothetical protein 0.0464 0.0386 0.0386
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0041 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0377 0.031 0.1441
Leishmania major cathepsin L-like protease 0.0228 0.0179 0.5782
Onchocerca volvulus 0.0073 0.0044 0.0377
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0023 0.0001 0.0001
Mycobacterium leprae Probable lipase LipE 0.0377 0.031 0.1133
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0024 0.0023
Entamoeba histolytica cysteine protease, putative 0.0031 0.0007 0.0164
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0042 0.0017 0.0142
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0026 0.0003 0.0002
Brugia malayi Cyclin, N-terminal domain containing protein 0.0043 0.0018 0.008
Plasmodium falciparum flap endonuclease 1 0.0026 0.0003 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0035 0.0298
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0017 0.0547
Brugia malayi orphan nuclear receptor NR2E1 0.0023 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0484 0.0404 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.016 0.012 0.012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0092 0.0061 0.1948
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0108
Echinococcus multilocularis mothers against decapentaplegic 2 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0319 0.026 0.1206
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0571 0.048 0.048
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0206 0.0161 0.5176
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0024 0.0108
Echinococcus granulosus cyclins 0.0043 0.0018 0.0017
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0319 0.026 0.0259
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0073 0.0044 0.1348
Loa Loa (eye worm) hypothetical protein 0.0185 0.0142 0.0658
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0012
Echinococcus granulosus lamin dm0 0.0131 0.0095 0.0095
Echinococcus multilocularis cyclins 0.0043 0.0018 0.0018
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0005 0.0005
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0092 0.0061 0.0214
Leishmania major cathepsin L-like protease 0.006 0.0032 0.1044
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0052 0.0026 0.0025
Echinococcus multilocularis dnaJ subfamily B 0.1479 0.1275 0.1275
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0215 0.0168 0.0781
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0024 0.0023
Loa Loa (eye worm) cysteine protease 0.006 0.0032 0.0149
Onchocerca volvulus Pyruvate kinase homolog 0.0029 0.0005 0.0044
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0007 0.0007
Toxoplasma gondii exonuclease III APE 0.0092 0.0061 0.1903
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0073 0.0044 0.0044
Echinococcus granulosus expressed protein 0.0032 0.0008 0.0008
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0319 0.026 0.8359
Trypanosoma brucei mitotic cyclin 6 0.0043 0.0018 0.0569
Treponema pallidum exodeoxyribonuclease (exoA) 0.0092 0.0061 0.2147
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0484 0.0404 1
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0032 0.0008 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0032 0.0279
Trichomonas vaginalis cyclins, putative 0.0043 0.0018 0.015
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0046 0.1488
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0024 0.0108
Loa Loa (eye worm) cyclin domain-containing protein 0.0295 0.0239 0.1109
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0215 0.0168 0.0168
Echinococcus multilocularis SAM and MBT domain containing protein 0.014 0.0103 0.0103
Trichomonas vaginalis pyruvate kinase, putative 0.0029 0.0005 0.0044
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0062 0.0035 0.0298
Brugia malayi Cyclin, N-terminal domain containing protein 0.0295 0.0239 0.1109
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0032 0.1985
Brugia malayi AMP-binding enzyme family protein 0.0247 0.0196 0.0912
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0006 0.0013
Trichomonas vaginalis inositol monophosphatase, putative 0.0026 0.0003 0.002
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0169 0.0128 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0017 0.0142
Leishmania major pyruvate kinase 0.0029 0.0005 0.0176
Brugia malayi Papain family cysteine protease containing protein 0.006 0.0032 0.0149
Schistosoma mansoni myo inositol monophosphatase 0.0026 0.0003 0.0002
Echinococcus granulosus mothers against decapentaplegic 6 0.003 0.0006 0.0006
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0024 0.0202
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0319 0.026 0.8359
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0087 0.0056 0.0206
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0073 0.0044 0.1407
Onchocerca volvulus 0.0073 0.0044 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0018 0.015
Echinococcus multilocularis cyclins 0.0043 0.0018 0.0018
Mycobacterium ulcerans acetyl-CoA synthetase 0.0073 0.0044 0.0151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0007 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0035 0.0298
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.0245 0.7896
Onchocerca volvulus 0.0032 0.0008 0.007
Loa Loa (eye worm) nuclear hormone receptor 0.0023 0.0001 0.0001
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0006 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0038 0.0331
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.3124 0.2715 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0169 0.0128 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0024 0.0108
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0026 0.0003 0.002
Brugia malayi hypothetical protein 0.0023 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.002 0.0167
Echinococcus granulosus fetal alzheimer antigen falz 0.0073 0.0044 0.0044
Echinococcus granulosus importin subunit beta 1 0.0027 0.0003 0.0003
Schistosoma mansoni importin beta-1 0.0027 0.0003 0.0003
Echinococcus granulosus phd:f box containing protein 0.0025 0.0002 0.0002
Onchocerca volvulus 0.0162 0.0122 0.1061
Brugia malayi mbt repeat family protein 0.014 0.0103 0.0477
Leishmania major cathepsin L-like protease 0.0228 0.0179 0.5782
Trichomonas vaginalis cyclin A, putative 0.0043 0.0018 0.015
Leishmania major phosphatidylinositol 3-kinase, putative 0.0028 0.0005 0.0151
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.007 0.0042 0.0192
Loa Loa (eye worm) hypothetical protein 0.014 0.0103 0.0477
Plasmodium vivax glutathione reductase, putative 0.0087 0.0056 0.1746
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0032 0.0008 0.0008
Loa Loa (eye worm) nuclear factor I 0.0037 0.0012 0.0056
Onchocerca volvulus 0.0131 0.0095 0.0826
Brugia malayi glutathione reductase 0.0087 0.0056 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0024 0.0108
Brugia malayi Thioredoxin reductase 0.0087 0.0056 0.0258
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0037
Entamoeba histolytica cysteine protease, putative 0.0031 0.0007 0.0164
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0012
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0032 0.1017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.0067 0.0039 0.0177
Schistosoma mansoni pyruvate kinase 0.0029 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0484 0.0404 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.0074 0.0073
Brugia malayi Pyruvate kinase, M2 isozyme 0.0029 0.0005 0.0023
Brugia malayi hypothetical protein 0.2477 0.2149 1
Loa Loa (eye worm) hypothetical protein 0.0679 0.0574 0.2672
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0206 0.0161 0.0161
Brugia malayi conserved hypotetical protein 0.0023 0.0001 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0009 0.0008
Loa Loa (eye worm) TAR-binding protein 0.0196 0.0152 0.0703
Entamoeba histolytica cysteine proteinase 1, putative 0.0031 0.0007 0.0164
Trypanosoma cruzi cysteine peptidase, putative 0.0228 0.0179 0.5777
Loa Loa (eye worm) transcription factor SMAD2 0.0979 0.0837 0.3895
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 1.1393 0.9954 0.9954
Mycobacterium ulcerans hypothetical protein 0.0247 0.0196 0.0714
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0024 0.0023
Onchocerca volvulus 0.004 0.0015 0.0128
Onchocerca volvulus 0.0505 0.0422 0.3679
Toxoplasma gondii propionate-CoA ligase 0.0073 0.0044 0.1348
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.0072 0.0072
Trichomonas vaginalis cyclins, putative 0.0043 0.0018 0.015
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0006 0.0138
Toxoplasma gondii thioredoxin reductase 0.0087 0.0056 0.1746
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0002 0.0002
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0028 0.0005 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0024 0.0205
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0024 0.0108
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0185 0.0142 0.0512
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0161 0.0121 0.0121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0228 0.0179 0.5782
Onchocerca volvulus 0.0131 0.0095 0.0826
Echinococcus multilocularis Smad4 0.0067 0.0039 0.0038
Onchocerca volvulus 0.0032 0.0008 0.007
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0002 0.0002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0024 0.0023
Brugia malayi hypothetical protein 0.0484 0.0404 0.1877
Echinococcus multilocularis lysosomal alpha glucosidase 0.0281 0.0226 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0032 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0015 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0043 0.0368
Onchocerca volvulus 0.008 0.005 0.043
Trypanosoma cruzi cyclin, putative 0.0043 0.0018 0.0556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0032 0.0279
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0063 0.0036 0.0035
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0247 0.0196 0.485
Onchocerca volvulus Huntingtin homolog 0.0596 0.0502 0.4372
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0007 0.0214
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.0112 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0024 0.0108
Brugia malayi PHD-finger family protein 0.0083 0.0053 0.0245
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0024 0.0023
Plasmodium falciparum acyl-CoA synthetase 0.0185 0.0142 0.5424
Toxoplasma gondii ABC1 family protein 0.0377 0.031 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0073 0.0044 0.0201
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.018 0.0138 0.0137
Toxoplasma gondii pyruvate kinase PyK1 0.0029 0.0005 0.0109
Mycobacterium ulcerans TetR family transcriptional regulator 0.3124 0.2715 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0017 0.0142
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0024 0.0108
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0073 0.0044 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.002 0.0167
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0073 0.0044 0.0201
Trypanosoma cruzi cruzipain precursor, putative 0.0228 0.0179 0.5777
Brugia malayi MH1 domain containing protein 0.0037 0.0012 0.0056
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0032 0.0279
Loa Loa (eye worm) hypothetical protein 0.0063 0.0036 0.0164
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0046 0.1441
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0197 0.0153 0.0563
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0108
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0006 0.0052
Echinococcus granulosus cathepsin L cysteine protease 0.0031 0.0007 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0005 0.0037
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0002 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0042 0.0017 0.0142
Echinococcus multilocularis cyclin b3 0.0043 0.0018 0.0018
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.018 0.0138 0.0138
Brugia malayi Cathepsin L-like precursor 0.006 0.0032 0.0149
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0002 0.0002
Echinococcus multilocularis cyclins 0.0043 0.0018 0.0018
Echinococcus multilocularis mothers against decapentaplegic 6 0.003 0.0006 0.0006
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0105 0.34
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0073 0.0044 0.1612
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0108
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0092 0.0061 0.0061
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0024 0.0023
Trichomonas vaginalis antibiotic synthetase, putative 0.0073 0.0044 0.0377
Brugia malayi exodeoxyribonuclease III family protein 0.0092 0.0061 0.0281
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0247 0.0196 0.0714
Brugia malayi RNA, U transporter 1 0.0076 0.0046 0.0214
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0247 0.0196 0.6315
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0377 0.031 0.1441
Entamoeba histolytica hypothetical protein 0.0027 0.0004 0.0084
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0032 0.0008 0.0037
Entamoeba histolytica cysteine protease, putative 0.0031 0.0007 0.0164
Schistosoma mansoni intermediate filament proteins 0.0131 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0012
Echinococcus multilocularis cyclins 0.0043 0.0018 0.0018
Schistosoma mansoni peptidase Clp (S14 family) 0.0319 0.026 0.0259
Echinococcus granulosus thioredoxin glutathione reductase 0.0087 0.0056 0.0055
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0484 0.0404 0.0403
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0005 0.0004
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.001 0.001
Mycobacterium ulcerans hypothetical protein 0.0159 0.012 0.0431
Leishmania major 4-coumarate:coa ligase-like protein 0.0247 0.0196 0.6335
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0084 0.0053 0.1721
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0024 0.0108
Brugia malayi hypothetical protein 0.0032 0.0008 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0377 0.031 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0032 0.0031
Schistosoma mansoni alpha-glucosidase 0.0241 0.0192 0.0191
Echinococcus granulosus histone lysine methyltransferase setb 0.0219 0.0172 0.0171
Schistosoma mansoni hypothetical protein 0.0215 0.0168 0.0168
Brugia malayi Pre-SET motif family protein 0.0172 0.013 0.0605
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0019 0.0596
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0247 0.0196 0.6315
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0073 0.0044 0.1395
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0003 0.0013
Mycobacterium tuberculosis Probable oxidoreductase 0.0219 0.0172 0.0634
Entamoeba histolytica cysteine protease, putative 0.0031 0.0007 0.0164
Schistosoma mansoni hypothetical protein 0.0044 0.0018 0.0018
Plasmodium vivax thioredoxin reductase, putative 0.0087 0.0056 0.1746
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0032 0.0032
Echinococcus granulosus Smad4 0.0067 0.0039 0.0038
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0032 0.0008 0.007
Brugia malayi Cathepsin L-like precursor 0.006 0.0032 0.0149
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0007 0.0164
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0024 0.0023
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0092 0.0061 0.1903
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0003 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0172 0.013 0.013
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0377 0.031 0.1142
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0754 0.064 0.0639
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0032 0.1029
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0046 0.1441
Trypanosoma brucei glycosyl hydrolase-like protein 0.0023 0 0.0013
Trypanosoma cruzi ISWI complex protein 0.0043 0.0017 0.0548
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0319 0.026 1
Echinococcus multilocularis pyruvate kinase 0.0029 0.0005 0.0005
Brugia malayi cathepsin L-like precursor 0.004 0.0015 0.0068
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0084 0.0053 0.1313
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0003 0.0002
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0032 0.0008 0.0008
Echinococcus granulosus beta LACTamase domain containing family member 0.0377 0.031 0.0309
Loa Loa (eye worm) hypothetical protein 0.0185 0.0142 0.0658
Trichomonas vaginalis alpha-glucosidase, putative 0.0062 0.0035 0.0298
Schistosoma mansoni Smad4 0.003 0.0006 0.0006
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0209 0.0163 0.0592
Onchocerca volvulus 0.0377 0.031 0.2699
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0028 0.0238
Brugia malayi Probable ClpP-like protease 0.0319 0.026 0.1206
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0084 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0215 0.0168 0.0781
Loa Loa (eye worm) hypothetical protein 0.0219 0.0172 0.0798
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0019 0.0596
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0377 0.031 0.1133
Onchocerca volvulus Mothers against decapentaplegic homolog 0.003 0.0006 0.0051
Mycobacterium tuberculosis Probable monophosphatase 0.0026 0.0003 0.001
Echinococcus multilocularis importin subunit beta 1 0.0027 0.0003 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0228 0.0179 0.5782
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0284 0.0229 0.1063
Schistosoma mansoni Smad4 0.0067 0.0039 0.0038
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0679 0.0574 0.2672
Leishmania major pantothenate kinase subunit, putative 0.0029 0.0005 0.0168
Echinococcus multilocularis lamin dm0 0.0131 0.0095 0.0095
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0007 0.0164
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0032 0.1017

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.026 ug ml-1 Inhibition of CDK4/Cyclin D1 expressed in Sf9 cells assessed as inhibition of Rb phosphorylation ChEMBL. 19889545
IC50 (functional) = 0.405 ug ml-1 Cytotoxicity against human HCT116 cells after 3 days by MTT assay ChEMBL. 19889545
IC50 (functional) = 0.598 ug ml-1 Cytotoxicity against human PC6 cells after 3 days by MTT assay ChEMBL. 19889545
IC50 (binding) = 1.1 ug ml-1 Inhibition of CDK2/Cyclin E expressed in Sf9 cells assessed as inhibition of Rb phosphorylation ChEMBL. 19889545

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19889545

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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