TDR Targets

Basic information

Technical information

TDR Targets ID: 1274081
Name: 1-(3-chlorophenyl)-3-pyridin-4-ylurea
MW: 247.68 | Formula: C12H10ClN3O
H donors: 2 H acceptors: 2 LogP: 2.04 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cccc(c1)Cl)Nc1ccncc1
InChi: 1S/C12H10ClN3O/c13-9-2-1-3-11(8-9)16-12(17)15-10-4-6-14-7-5-10/h1-8H,(H2,14,15,16,17)
InChiKey: QGFXRTDUZHCUGA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(3-chlorophenyl)-3-(4-pyridyl)urea
1-(3-chlorophenyl)-3-pyridin-4-yl-urea
IVK/8047886

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	multiple endocrine neoplasia I		No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Plasmodium falciparum	NIMA related kinase 4	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.2233	1	1
Schistosoma mansoni	P21-activated kinase pak	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	serine/threonine protein kinase STE20, putative	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, PEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0173	0.017
Plasmodium falciparum	serine/threonine protein kinase	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0173	1
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Echinococcus granulosus	cpg binding protein	0.0037	0.0142	0.0139
Schistosoma mansoni	sodium/chloride dependent transporter	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0567
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0173	0.017
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0567
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Giardia lamblia	Kinase, Wnk	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0173	0.1388
Plasmodium falciparum	serine/threonine protein kinase	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Plasmodium falciparum	protein kinase, putative	0.0006	0.0003	0.5
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0173	0.1388
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	serine/threonine-protein kinase 3, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Entamoeba histolytica	serine/threonine- protein kinase C823.03, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CMGC CDKL	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0567
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0567
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0173	0.017
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0006	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0173	0.017
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	protein kinase 7	0.0006	0.0003	0.5
Plasmodium falciparum	tyrosine kinase-like protein, putative	0.0006	0.0003	0.5
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0173	0.1388
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	cpg binding protein	0.0035	0.0133	0.0133
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	EKC/KEOPS complex subunit BUD32	0.0006	0.0003	0.5
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0173	0.017
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, CMGC CDK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase , putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-like	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0026	0.0023
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0006	0.0003	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0173	0.1388
Giardia lamblia	Kinase, CDC7	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Brugia malayi	beta-lactamase	0.0043	0.0173	0.017
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Brugia malayi	beta-lactamase family protein	0.0043	0.0173	0.017
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0173	0.017
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	glycogen synthase kinase 3	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0273	1
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0013	0.0567
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0025	0.0022
Giardia lamblia	Kinase, NAK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	ste20-related kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0016	0.0016
Entamoeba histolytica	cell division protein kinase 2, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase C mu	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0173	0.1388
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0013	0.0567
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0013	0.0567
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Entamoeba histolytica	cell division protein kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	P21-activated kinase pak	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, STE STE20	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, AGC MAST	0.0006	0.0003	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	cdc2-related protein kinase 1	0.0006	0.0003	0.5
Entamoeba histolytica	cell division protein kinase 2, putative	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Plasmodium falciparum	calcium-dependent protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, AGC PKA	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, CAMKK	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, STE STE20	0.0006	0.0003	0.5
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0173	1
Plasmodium falciparum	cdc2-related protein kinase 3	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CMGC CDK	0.0006	0.0003	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CMGC SRPK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CMGC MAPK	0.0006	0.0003	0.5
Onchocerca volvulus		0.0035	0.0133	0.767
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, CMGC CMGC-GL1	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	dual specificity kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, CAMK unique	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0013	0.0567
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CMGC RCK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Plasmodium falciparum	protein kinase 6	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	protein kinase 2	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, CK1 Casein kinase	0.0006	0.0003	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0173	0.017
Giardia lamblia	Kinase, AGC PKA	0.0006	0.0003	0.5
Echinococcus granulosus	dnaJ subfamily B	0.0494	0.2195	0.2192
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0006	0.0003	0.5
Entamoeba histolytica	p21-activated kinase	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CAMK CAMKL	0.0006	0.0003	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0567
Entamoeba histolytica	cyclin-dependent kinase protein, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, CMGC GSK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0173	0.1388
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0173	1
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Leishmania major	hypothetical protein, conserved	0.0043	0.0173	1
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	NIMA related kinase 1	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	casein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, STE STE20	0.0006	0.0003	0.5
Entamoeba histolytica	casein kinase II alpha subunit, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, CMGC CDK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	tyrosine kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	eukaryotic translation initiation factor 2-alpha kinase	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, AGC AKT	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0006	0.0003	0.5
Plasmodium falciparum	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	cell division protein kinase, putative	0.0006	0.0003	0.5
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0173	0.017
Schistosoma mansoni	serine/threonine-protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0567
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	protein kinase, putative	0.0006	0.0003	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0173	1
Giardia lamblia	Kinase, NEK-like	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Chlamydia trachomatis	serine/threonine protein kinase	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Trichomonas vaginalis	helicase, putative	0.0008	0.0013	0.0567
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Toxoplasma gondii	ABC1 family protein	0.0043	0.0173	0.6295
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Giardia lamblia	Kinase, Uni1	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0173	0.017
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0013	0.0567
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	casein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-GL-like	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Plasmodium falciparum	protein serine/threonine kinase-1	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	NIMA related kinase 2	0.0006	0.0003	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.0308	0.0308
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	dual specificity kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CMGC DYRK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0133	0.013
Plasmodium falciparum	mitogen-activated protein kinase 1	0.0006	0.0003	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0567
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Chlamydia trachomatis	serine/threonine protein kinase	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase C mu	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Plasmodium falciparum	protein kinase 1	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Plasmodium falciparum	cGMP-dependent protein kinase	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, CMGC DYRK	0.0006	0.0003	0.5
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.2233	1	1
Giardia lamblia	Kinase, ULK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CMGC CDK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	cpg binding protein	0.0037	0.0142	0.0142
Schistosoma mansoni	cAMP-dependent protein kinase catalytic subunit	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Plasmodium falciparum	calcium-dependent protein kinase 6	0.0006	0.0003	0.5
Schistosoma mansoni	P38 MAPk	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, CMGC CDK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	hypothetical protein	0.0494	0.2195	0.2195
Plasmodium falciparum	calcium/calmodulin-dependent protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, Nek-like	0.0006	0.0003	0.5
Giardia lamblia	Kinase, Nek-like	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	cpg binding protein	0.0037	0.0142	0.0142
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	dual specificity kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Echinococcus multilocularis	dnaJ subfamily B	0.0494	0.2195	0.2192
Giardia lamblia	Kinase, NAK	0.0006	0.0003	0.5
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0173	0.1388
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CMGC CLK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Schistosoma mansoni	peptidase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	HEAT repeat domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0173	1
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0173	0.0173
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0173	1
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Plasmodium falciparum	protein kinase 5	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, PLK	0.0006	0.0003	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	kinase	0.0006	0.0003	0.0003
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.2233	1	1
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0173	1
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, CMGC MAPK	0.0006	0.0003	0.5
Schistosoma mansoni	dual specificity serine/threonine tyrosine kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	titin	0.0006	0.0003	0.0003
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0173	1
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0013	0.0567
Entamoeba histolytica	serine/threonine- protein kinase DCAMKL3, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CMGC CMGC-GL1	0.0006	0.0003	0.5
Plasmodium falciparum	NIMA related kinase 3	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, TTK	0.0006	0.0003	0.5
Schistosoma mansoni	hypothetical protein	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, CMGC CK2	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	cdc2-related protein kinase 5	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0173	0.1388
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase with WD repeats	0.0006	0.0003	0.5
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0173	1
Giardia lamblia	Kinase, CMGC DYRK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0013	0.0567
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0173	0.017
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Brugia malayi	beta-lactamase family protein	0.0043	0.0173	0.017
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Entamoeba histolytica	casein kinase I isoform delta, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CMGC RCK	0.0006	0.0003	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Aurora kinase	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	cGMP-dependent protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	Rab GTPase activating protein, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, ULK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	eukaryotic initiation factor 2alpha kinase 1	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	protein kinase, putative	0.0006	0.0003	0.5
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0016	0.0013
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CAMK CAMKL	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CAMK CAMKL	0.0006	0.0003	0.5
Giardia lamblia	Hypothetical protein	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, VPS15	0.0006	0.0003	0.5
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0016	0.0013
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	MO15-related protein kinase	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0026	0.0023
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0173	1
Giardia lamblia	Kinase, CAMK CAMK1	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine-protein kinase	0.0006	0.0003	0.0003
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0016	0.0013
Entamoeba histolytica	casein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0173	1
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0173	0.1388
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	predicted protein	0.0006	0.0003	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, STE Dicty2	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0173	1
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Trichomonas vaginalis	esterase, putative	0.0043	0.0173	1
Giardia lamblia	Kinase, NEK-like	0.0006	0.0003	0.5
Giardia lamblia	Kinase, STE STE20	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Mycobacterium ulcerans	lipase LipD	0.0043	0.0173	1
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, STE Dicty2	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	mitogen-activated protein kinase	0.0006	0.0003	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0567
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase 2, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0173	1
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, STE STE20	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	cell division protein kinase 2, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-like	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0013	0.0567
Plasmodium falciparum	cdc2-related protein kinase 4	0.0006	0.0003	0.5
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.2233	1	1
Plasmodium falciparum	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, CMGC CDK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0013	0.0567
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0173	0.017
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Echinococcus multilocularis	cpg binding protein	0.0037	0.0142	0.0139
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, STE STE11	0.0006	0.0003	0.5
Entamoeba histolytica	casein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	casein kinase 1, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK-frag	0.0006	0.0003	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0026	0.0023
Plasmodium falciparum	tyrosine kinase-like protein, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	calcium/calmodulin-dependent protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, Wee	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, AGC NDR	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0016	0.0013
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Onchocerca volvulus		0.0043	0.0173	1
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	atypical protein kinase C	0.0006	0.0003	0.0003
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0173	0.1388
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0173	0.0173
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Chlamydia trachomatis	serine/threonine-protein kinase	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Plasmodium falciparum	casein kinase 1	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Plasmodium falciparum	serine/threonine protein kinase KIN	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0173	1
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	casein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Onchocerca volvulus		0.0043	0.0173	1
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, CAMK CAMKL	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.1224	1
Schistosoma mansoni	myotonic dystrophy kinase-related cdc42-binding kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, STE STE20	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CMGC GSK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, CMGC DYRK	0.0006	0.0003	0.5
Schistosoma mansoni	MAPk	0.0006	0.0003	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Schistosoma mansoni	MAGUK homolog	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Giardia lamblia	Long-flagella protein, kinase, CMGC RCK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Giardia lamblia	Kinase, CAMK CAMKL	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	tyrosine kinase, putative	0.0006	0.0003	0.5
Plasmodium falciparum	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Giardia lamblia	Kinase, NEK-like	0.0006	0.0003	0.5
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0006	0.0003	0.5
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0133	0.013
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0006	0.0003	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0173	1
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0006	0.0003	0.5
Giardia lamblia	Kinase, NEK	0.0006	0.0003	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0003	0.5
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	protein kinase	0.0006	0.0003	0.0003
Onchocerca volvulus		0.0043	0.0173	1
Entamoeba histolytica	protein kinase, putative	0.0006	0.0003	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0003	0.0003

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 1.2589 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	1.4716 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	23.0999 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	26.8545 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1383858

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1274081