Detailed information for compound 1275728

Basic information

Technical information
  • TDR Targets ID: 1275728
  • Name: [2-[[2-(4-chlorophenyl)sulfanylphenyl]amino]- 2-oxoethyl] 2-(4-oxoquinazolin-3-yl)acetate
  • MW: 479.935 | Formula: C24H18ClN3O4S
  • H donors: 1 H acceptors: 3 LogP: 4.41 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1Sc1ccc(cc1)Cl)COC(=O)Cn1cnc2c(c1=O)cccc2
  • InChi: 1S/C24H18ClN3O4S/c25-16-9-11-17(12-10-16)33-21-8-4-3-7-20(21)27-22(29)14-32-23(30)13-28-15-26-19-6-2-1-5-18(19)24(28)31/h1-12,15H,13-14H2,(H,27,29)
  • InChiKey: WWVXBOCFSAFMTC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[[2-(4-chlorophenyl)sulfanylphenyl]amino]-2-oxo-ethyl] 2-(4-oxoquinazolin-3-yl)acetate
  • 2-(4-oxo-3-quinazolinyl)acetic acid [2-[[2-[(4-chlorophenyl)thio]phenyl]amino]-2-oxoethyl] ester
  • 2-(4-ketoquinazolin-3-yl)acetic acid [2-[[2-[(4-chlorophenyl)thio]phenyl]amino]-2-keto-ethyl] ester
  • [2-[[2-(4-chlorophenyl)sulfanylphenyl]amino]-2-oxo-ethyl] 2-(4-oxoquinazolin-3-yl)ethanoate
  • MLS000389420
  • SMR000255693
  • T5211674

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Mus musculus transient receptor potential cation channel, subfamily C, member 4 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma mansoni transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus TRP transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Transient-receptor-potential like protein Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni transient receptor potential channel 4 Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis TRP (transient receptor potential) channel Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum Transient receptor potential-gamma protein, putative Get druggable targets OG5_128782 All targets in OG5_128782
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Echinococcus multilocularis short transient receptor potential channel 6 transient receptor potential cation channel, subfamily C, member 4 890 aa 799 aa 31.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus RNA directed DNA polymerase 0.004 0.0005 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0426 0.1683
Loa Loa (eye worm) hypothetical protein 0.0058 0.0183 0.0202
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0082 0.0422 0.0465
Echinococcus multilocularis tensin 0.005 0.0107 0.0129
Entamoeba histolytica p21-activated kinase 0.0092 0.0525 0.1522
Brugia malayi serine/threonine-protein kinase 6 0.0088 0.0481 0.0528
Entamoeba histolytica DNA topoisomerase II, putative 0.0293 0.2519 0.7327
Brugia malayi Kinase associated domain 1 family protein 0.0072 0.0325 0.0356
Echinococcus multilocularis roundabout 2 0.0047 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0057 0.0175 0.0192
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0633 0.5897 0.6495
Loa Loa (eye worm) hypothetical protein 0.0091 0.0507 0.0559
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0355 0.3136 0.3454
Brugia malayi phosphoinositide-dependent protein kinase I 0.008 0.0403 0.0442
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.113 0.2427
Echinococcus granulosus activin receptor type 0.0068 0.0281 0.0286
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0069 0.0295 0.0301
Schistosoma mansoni kinase 0.0242 0.2009 0.4315
Schistosoma mansoni septate junction protein 0.0041 0.0009 0.0015
Onchocerca volvulus 0.0145 0.1046 0.2052
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0176 0.1352 0.1382
Echinococcus multilocularis 0.0153 0.1125 0.1381
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0633 0.1356
Brugia malayi Immunoglobulin I-set domain containing protein 0.0059 0.0193 0.0211
Loa Loa (eye worm) AUR protein kinase 0.0088 0.0481 0.053
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.1042 0.2236
Plasmodium falciparum protein serine/threonine kinase-1 0.0153 0.113 0.1129
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.01 0.0598 0.0659
Loa Loa (eye worm) AUR protein kinase 0.0088 0.0481 0.053
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0338 0.2964 0.3265
Schistosoma mansoni septate junction protein 0.0041 0.0009 0.0015
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0591 0.2339
Trypanosoma cruzi cdc2-related kinase 3 0.0118 0.0779 0.2111
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1039 0.1144
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0083 0.0435 0.1176
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0223 0.1822 0.1863
Echinococcus multilocularis myosin iiia 0.0083 0.0435 0.0532
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0088 0.0483 0.0481
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0153 0.113 0.1129
Schistosoma mansoni nephrin 0.0113 0.0726 0.1557
Echinococcus multilocularis casein kinase I alpha 0.0108 0.0677 0.083
Leishmania major casein kinase II, putative 0.0099 0.0591 0.1599
Onchocerca volvulus 0.0059 0.0193 0.0376
Echinococcus granulosus SH2 domain containing adapter protein F 0.005 0.0107 0.0107
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.007 0.0075
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0082 0.0422 0.0465
Brugia malayi Protein kinase domain containing protein 0.0201 0.1606 0.1767
Entamoeba histolytica protein kinase, putative 0.0122 0.0814 0.2363
Brugia malayi MH2 domain containing protein 0.0144 0.1039 0.1142
Schistosoma mansoni hypothetical protein 0.0301 0.2602 0.5591
Entamoeba histolytica protein kinase, putative 0.0122 0.0814 0.2363
Echinococcus granulosus mitogen activated protein kinase 3 0.0082 0.0426 0.0434
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0159 0.1186 0.3215
Schistosoma mansoni protein kinase 0.0231 0.1905 0.4093
Echinococcus granulosus tyrosine protein kinase Src42A 0.0142 0.1014 0.1036
Entamoeba histolytica hypothetical protein 0.0385 0.3438 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.1005 0.1107
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0231 0.1905 0.1949
Brugia malayi Protein kinase domain containing protein 0.0153 0.113 0.1243
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0298 0.2566 0.3152
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0164 0.1233 0.1358
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0453 0.4104 0.452
Echinococcus granulosus serine:threonine protein kinase N2 0.0285 0.2441 0.2497
Echinococcus granulosus Glutaredoxin protein 5 0.0125 0.0852 0.0871
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.0385 0.152
Echinococcus multilocularis dual specificity 0.0122 0.0814 0.0998
Echinococcus multilocularis hypothetical protein 0.0072 0.0325 0.0397
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0233 0.1921 0.2116
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0093 0.0361
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0082 0.0426 0.115
Loa Loa (eye worm) hypothetical protein 0.0085 0.045 0.0495
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0381 0.0388
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0144 0.1042 0.1065
Entamoeba histolytica diacylglycerol kinase, putative 0.0042 0.0027 0.0074
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0208 0.1677 0.2059
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0381 0.0379
Echinococcus multilocularis serine:threonine protein kinase N2 0.0132 0.0913 0.112
Loa Loa (eye worm) hypothetical protein 0.01 0.0598 0.0659
Onchocerca volvulus 0.0493 0.4503 0.8847
Echinococcus granulosus netrin receptor unc 5 0.005 0.0098 0.0098
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Trypanosoma cruzi aurora B kinase, putative 0.0088 0.0481 0.1301
Echinococcus granulosus c-Jun N-terminal kinases 0.0266 0.2246 0.2298
Entamoeba histolytica serine/threonine protein kinase, putative 0.0049 0.0093 0.0264
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0481 0.1903
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0082 0.0426 0.115
Brugia malayi RNA, U transporter 1 0.008 0.0404 0.0443
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0203 0.1624 0.1789
Loa Loa (eye worm) hypothetical protein 0.0041 0.0009 0.001
Loa Loa (eye worm) AGC/PKA protein kinase 0.0112 0.0721 0.0794
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0128 0.0879 0.1885
Brugia malayi Variant SH3 domain containing protein 0.0082 0.0422 0.0463
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0134 0.0938 0.1151
Echinococcus granulosus tensin C1 domain containing phosphatase 0.005 0.0107 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0721 0.1546
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0591 0.2339
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0481 0.1903
Trypanosoma cruzi casein kinase, putative 0.0108 0.0677 0.1833
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.041 0.3685 1
Echinococcus multilocularis hemicentin 1 0.0041 0.0009 0.0009
Brugia malayi hypothetical protein 0.0088 0.0478 0.0524
Trypanosoma cruzi NIMA-related kinase, putative 0.0049 0.0093 0.0247
Plasmodium falciparum cGMP-dependent protein kinase 0.0134 0.0938 0.0937
Trypanosoma brucei casein kinase I, isoform 2 0.0108 0.0677 0.1833
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.1042 0.2236
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0068 0.0281 0.0286
Echinococcus multilocularis rho associated protein kinase 0.0327 0.286 0.3514
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0459 0.4165 0.4098
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0088 0.0478 0.1023
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0087 0.0475 0.1376
Entamoeba histolytica protein kinase domain containing protein 0.0099 0.0591 0.1714
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0395 0.3534 0.4342
Echinococcus granulosus mitogen activated protein kinase 0.0082 0.0426 0.0434
Schistosoma mansoni hypothetical protein 0.0042 0.0027 0.0054
Echinococcus granulosus tyrosine protein kinase Srms 0.0501 0.4585 0.4693
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0136 0.0954 0.0952
Leishmania major protein kinase, putative 0.0088 0.0481 0.1301
Brugia malayi Protein kinase domain containing protein 0.0606 0.5631 0.6202
Echinococcus granulosus casein kinase I gamma 0.0214 0.1731 0.1771
Trypanosoma brucei rac serine-threonine kinase, putative 0.0287 0.2456 0.6665
Brugia malayi tRNA modification GTPase TrmE family protein 0.005 0.0107 0.0116
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0051 0.0113 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.1236 0.2653
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.007 0.0075
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0381 0.0379
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.2441 0.5244
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0201 0.1605 0.1971
Brugia malayi Protein kinase domain containing protein 0.0164 0.1236 0.1359
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Entamoeba histolytica protein kinase, putative 0.0126 0.086 0.2498
Echinococcus granulosus hemicentin 1 0.0041 0.0009 0.0007
Echinococcus granulosus Diacylglycerol kinase theta 0.0042 0.0027 0.0026
Schistosoma mansoni protein kinase C 0.0044 0.004 0.0082
Echinococcus granulosus cGMP dependent protein kinase 1 0.0134 0.0938 0.0959
Brugia malayi Temporarily assigned gene name protein 59 0.0088 0.0478 0.0524
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.2246 0.4825
Entamoeba histolytica PH domain containing protein kinase, putative 0.012 0.0797 0.2315
Schistosoma mansoni protein kinase 0.0193 0.1525 0.3276
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0459 0.4165 0.4164
Echinococcus granulosus cyclin dependent kinase 1 0.0118 0.0779 0.0796
Brugia malayi Tyrosine-protein kinase abl-1 0.013 0.0897 0.0986
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0088 0.0483 0.1306
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0983 0.3895
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0201 0.1606 0.1768
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0677 0.1451
Schistosoma mansoni protein kinase 0.0068 0.0281 0.0601
Loa Loa (eye worm) TK protein kinase 0.0345 0.3032 0.334
Loa Loa (eye worm) hypothetical protein 0.0054 0.014 0.0155
Entamoeba histolytica protein kinase domain containing protein 0.0122 0.0814 0.2363
Loa Loa (eye worm) hypothetical protein 0.0091 0.0507 0.0559
Schistosoma mansoni cell adhesion molecule 0.0047 0.007 0.0146
Echinococcus multilocularis ephrin type A receptor 4 A 0.0102 0.0619 0.0759
Schistosoma mansoni atypical protein kinase C 0.0286 0.2452 0.5269
Echinococcus multilocularis RNA directed DNA polymerase 0.004 0.0005 0.0004
Echinococcus multilocularis nervana 2 0.0125 0.0852 0.1046
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0118
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0112 0.0721 0.0719
Loa Loa (eye worm) hypothetical protein 0.0091 0.0507 0.0559
Loa Loa (eye worm) protein-tyrosine phosphatase 0.005 0.0107 0.0118
Loa Loa (eye worm) TK/FER protein kinase 0.0395 0.3534 0.3892
Brugia malayi Protein-tyrosine phosphatase containing protein 0.005 0.0107 0.0116
Entamoeba histolytica PH domain containing protein kinase, putative 0.0164 0.1237 0.3594
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0108 0.0677 0.1833
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.1352 0.2903
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0093 0.0361
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0208 0.1677 0.2059
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0123 0.0825 0.327
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0397 0.3556 0.3639
Echinococcus granulosus lachesin 0.0041 0.0009 0.0007
Echinococcus granulosus defective proboscis extension response 0.0085 0.0447 0.0455
Schistosoma mansoni titin 0.0041 0.0009 0.0015
Brugia malayi RhoGEF domain containing protein 0.0042 0.0027 0.0028
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0009 0.0008
Schistosoma mansoni protein kinase C mu 0.0218 0.1776 0.3814
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0083 0.0435 0.1176
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0475 0.0523
Echinococcus multilocularis suppressor of cytokine signaling 6 0.005 0.0107 0.0129
Plasmodium vivax serine/threonine-protein kinase Nek1, putative 0.0049 0.0093 0.0091
Brugia malayi Stress-activated protein kinase jnk-1 0.0266 0.2246 0.2472
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0068 0.0281 0.0344
Chlamydia trachomatis DNA gyrase subunit B 0.0341 0.3 0.2999
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0042 0.0027 0.003
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0254 0.2135 0.2622
Schistosoma mansoni serine/threonine protein kinase 0.0397 0.3556 0.7642
Echinococcus granulosus epidermal growth factor receptor 0.0318 0.2768 0.2832
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0118
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0438 0.3957 0.4862
Brugia malayi C1-like domain containing protein 0.0218 0.1776 0.1954
Schistosoma mansoni tyrosine kinase 0.0459 0.4167 0.8955
Echinococcus granulosus tyrosine protein kinase otk 0.0041 0.0009 0.0007
Brugia malayi Protein kinase domain containing protein 0.008 0.0403 0.0442
Echinococcus granulosus tyrosine kinase 0.0177 0.1361 0.1392
Onchocerca volvulus 0.005 0.0107 0.0206
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0983 0.3895
Brugia malayi Protein kinase domain containing protein 0.0953 0.9079 1
Brugia malayi Protein kinase domain containing protein 0.0122 0.0814 0.0895
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1039 0.1144
Schistosoma mansoni growth factor receptor-bound protein 0.0082 0.0422 0.0903
Echinococcus multilocularis CDC7 cell division cycle 7 0.0089 0.0486 0.0596
Schistosoma mansoni cell adhesion molecule 0.0109 0.0692 0.1484
Trypanosoma cruzi DNA topoisomerase II, putative 0.0253 0.2123 0.576
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0081 0.0415 0.1202
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0112 0.0721 0.1952
Echinococcus granulosus titin 0.0059 0.0193 0.0196
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0208 0.1677 0.1715
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0015 0.0014
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0203 0.1624 0.1661
Echinococcus granulosus geminin 0.0508 0.4653 0.4762
Echinococcus granulosus hypothetical protein 0.0122 0.0822 0.084
Loa Loa (eye worm) DNA topoisomerase III 0.004 0.0002 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0779 0.1671
Brugia malayi RhoGAP domain containing protein 0.0042 0.0027 0.0028
Schistosoma mansoni tyrosine kinase 0.0397 0.3557 0.7643
Schistosoma mansoni tyrosine kinase 0.0119 0.079 0.1694
Brugia malayi Hr1 repeat family protein 0.0285 0.2441 0.2687
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0186 0.1455 0.1786
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0381 0.0379
Trypanosoma brucei Serine/threonine-protein kinase NEK11, putative 0.0049 0.0093 0.0247
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0281 0.0814
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0355 0.3136 0.3854
Onchocerca volvulus 0.005 0.0107 0.0206
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0088 0.0478 0.1292
Brugia malayi Probable ClpP-like protease 0.0078 0.0381 0.0417
Echinococcus granulosus serine:threonine protein kinase 3 0.0258 0.2171 0.2221
Echinococcus multilocularis hemicentin 1 0.0041 0.0009 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0779 0.1671
Plasmodium vivax casein kinase 1, putative 0.0108 0.0677 0.0675
Entamoeba histolytica casein kinase 1, putative 0.0108 0.0677 0.1965
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.1352 0.5362
Echinococcus multilocularis SHC transforming protein 3 0.005 0.0107 0.0129
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0041 0.0009 0.0014
Brugia malayi Sex muscle abnormal protein 5 0.0082 0.0422 0.0463
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0223 0.1822 0.2238
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0139 0.0983 0.108
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.1967 0.4226
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.008 0.0403 0.0444
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0082 0.0419 0.1133
Schistosoma mansoni transient receptor potential channel 0.0078 0.0377 0.0807
Echinococcus multilocularis snurportin 1 0.0301 0.2602 0.3197
Onchocerca volvulus 0.0077 0.0369 0.0721
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0136 0.0954 0.0952
Giardia lamblia Kinase, NEK 0.0136 0.0954 0.4063
Echinococcus granulosus cyclin dependent kinase 5 0.0118 0.0779 0.0796
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0779 0.3088
Echinococcus multilocularis mitogen activated protein kinase 11 0.0159 0.1186 0.1456
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0303 0.2617 0.3215
Echinococcus granulosus tyrosine protein kinase Fyn 0.0208 0.1677 0.1715
Entamoeba histolytica hypothetical protein 0.0042 0.0027 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Echinococcus multilocularis mitogen activated protein kinase 3 0.0082 0.0426 0.0521
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0114 0.0114
Entamoeba histolytica protein kinase, putative 0.0154 0.1133 0.3293
Schistosoma mansoni serine/threonine protein kinase 0.021 0.1696 0.3643
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0486 0.1925
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0134 0.0938 0.1151
Schistosoma mansoni tyrosine kinase 0.0078 0.0377 0.0806
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0068 0.0281 0.028
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0426 0.1683
Brugia malayi SH2 domain containing protein 0.0087 0.0475 0.0521
Schistosoma mansoni serine/threonine protein kinase 0.0239 0.1981 0.4256
Plasmodium falciparum DNA gyrase subunit B 0.0459 0.4165 0.4164
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.1352 0.5362
Plasmodium vivax serine/threonine protein kinase, putative 0.0082 0.0419 0.0417
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0068 0.0281 0.0759
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0381 0.0979
Echinococcus multilocularis 0.0122 0.0822 0.1009
Echinococcus multilocularis casein kinase I alpha 0.0108 0.0677 0.083
Trypanosoma brucei Serine/threonine-protein kinase NEK16, putative 0.0049 0.0093 0.0247
Entamoeba histolytica protein kinase domain containing protein 0.0203 0.1624 0.4722
Leishmania major protein kinase A catalytic subunit isoform 1 0.0112 0.0721 0.1952
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.041 0.3685 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0231 0.1905 0.234
Brugia malayi ephrin receptor 1 precursor 0.0068 0.0278 0.0304
Entamoeba histolytica protein kinase, putative 0.0081 0.0415 0.1202
Schistosoma mansoni tyrosine kinase 0.0318 0.2768 0.5947
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0218 0.1776 0.1954
Loa Loa (eye worm) hypothetical protein 0.0187 0.1467 0.1616
Echinococcus multilocularis calcium dependent protein kinase 0.0069 0.029 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.014 0.055
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0381 0.0379
Trichomonas vaginalis CAMK family protein kinase 0.0072 0.0323 0.1275
Schistosoma mansoni protein kinase 0.0099 0.0591 0.1266
Entamoeba histolytica protein kinase, putative 0.0082 0.0419 0.1215
Brugia malayi Ras association domain family 1 isoform A 0.0042 0.0027 0.0028
Brugia malayi P38 map kinase family protein 2 0.0159 0.1186 0.1304
Echinococcus multilocularis raf serine:threonine protein kinase 0.0079 0.0395 0.0483
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0879 0.3483
Entamoeba histolytica protein kinase, putative 0.0082 0.0419 0.1215
Brugia malayi SH2 domain containing protein 0.005 0.0107 0.0116
Echinococcus granulosus SH2 motif 0.005 0.0107 0.0107
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0231 0.1905 0.2099
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0151 0.1102 0.1214
Echinococcus granulosus suppressor of cytokine signaling 6 0.005 0.0107 0.0107
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0098 0.0106
Brugia malayi Casein kinase II, alpha chain 0.0099 0.0591 0.0649
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0239 0.1981 0.2027
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0177 0.1361 0.1392
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0381 0.0466
Loa Loa (eye worm) hypothetical protein 0.0072 0.0323 0.0356
Echinococcus granulosus NCK adaptor protein 0.0082 0.0422 0.043
Echinococcus granulosus tensin 0.005 0.0107 0.0107
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0085 0.0449 0.0549
Loa Loa (eye worm) hypothetical protein 0.0087 0.0471 0.0519
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0088 0.0478 0.0487
Echinococcus granulosus expressed conserved protein 0.005 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.003
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0338 0.2964 0.3263
Schistosoma mansoni serine/threonine protein kinase 0.0355 0.3136 0.6739
Brugia malayi Protein kinase c protein 2 0.0115 0.0748 0.0822
Brugia malayi Protein kinase domain containing protein 0.0087 0.0475 0.0521
Loa Loa (eye worm) hypothetical protein 0.004 0.0005 0.0006
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.113 0.4483
Loa Loa (eye worm) hypothetical protein 0.0088 0.0478 0.0526
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Echinococcus granulosus serine:threonine kinase SAD 1 0.0088 0.0483 0.0492
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0475 0.0523
Onchocerca volvulus 0.0108 0.0677 0.1327
Echinococcus granulosus calcium dependent protein kinase 0.0069 0.029 0.0295
Schistosoma mansoni protein kinase 0.0241 0.1998 0.4291
Schistosoma mansoni tyrosine kinase 0.0281 0.24 0.5156
Loa Loa (eye worm) hypothetical protein 0.0041 0.0009 0.001
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0142 0.1014 0.1244
Schistosoma mansoni rac gtpase activating protein 0.0042 0.0027 0.0054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0204 0.0223
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.113 0.2427
Echinococcus granulosus protein kinase shaggy 0.0128 0.0879 0.0898
Echinococcus multilocularis peroxidasin 0.0041 0.0012 0.0012
Plasmodium falciparum protein kinase, putative 0.0068 0.0281 0.028
Echinococcus granulosus nervana 2 0.0125 0.0852 0.0871
Brugia malayi Transient-receptor-potential like protein 0.0044 0.0039 0.0041
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0082 0.0426 0.115
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.007 0.0075
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0077 0.0369 0.0996
Toxoplasma gondii AGC kinase 0.0112 0.0721 0.0719
Loa Loa (eye worm) hypothetical protein 0.0141 0.1005 0.1107
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0085 0.0449 0.0457
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.003
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0176 0.1352 0.166
Schistosoma mansoni serine/threonine protein kinase 0.0223 0.1822 0.3913
Schistosoma mansoni shc transforming protein 0.005 0.0107 0.0225
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0355 0.3136 0.616
Brugia malayi Protein kinase domain containing protein 0.0397 0.3557 0.3916
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.003
Giardia lamblia Kinase, CMGC GSK 0.0128 0.0879 0.3741
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0153 0.113 0.3064
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0144 0.1042 0.1065
Giardia lamblia Kinase, CMGC SRPK 0.0082 0.0419 0.1781
Entamoeba histolytica protein kinase domain containing protein 0.0139 0.0983 0.2854
Brugia malayi Protein kinase domain containing protein 0.0231 0.1905 0.2097
Echinococcus multilocularis serine threonine protein kinase 0.0195 0.1546 0.1898
Giardia lamblia DNA topoisomerase II 0.0276 0.2345 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.004 0.0044
Brugia malayi Immunoglobulin I-set domain containing protein 0.026 0.2191 0.2412
Brugia malayi hypothetical protein 0.0087 0.0475 0.0521
Schistosoma mansoni tyrosine kinase 0.0119 0.079 0.1694
Plasmodium vivax tyrosine kinase-like protein, putative 0.008 0.0398 0.0396
Onchocerca volvulus 0.0065 0.0251 0.049
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0099 0.0591 0.0651
Loa Loa (eye worm) AGC/PKN protein kinase 0.0285 0.2441 0.2688
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0041 0.0009 0.001
Trichomonas vaginalis AGC family protein kinase 0.0287 0.2456 0.975
Loa Loa (eye worm) AGC/PKG protein kinase 0.0134 0.0938 0.1034
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0598 0.0733
Echinococcus multilocularis unc 13 (munc13) 0.0044 0.004 0.0047
Echinococcus multilocularis SH2 domain containing adapter protein F 0.005 0.0107 0.0129
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Brugia malayi Temporarily assigned gene name protein 59 0.0131 0.0906 0.0996
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0049 0.0093 0.0247
Giardia lamblia Kinase, CAMK CAMKL 0.0088 0.0483 0.2052
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0156 0.1161 0.1159
Toxoplasma gondii histone kinase SNF1, putative 0.0088 0.0483 0.0481
Schistosoma mansoni tensin 0.005 0.0107 0.0225
Echinococcus granulosus twitchin 0.0138 0.0974 0.0995
Echinococcus granulosus rho-associated protein kinase 1 0.0327 0.286 0.2926
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.1624 0.3489
Trichomonas vaginalis AGC family protein kinase 0.0287 0.2456 0.975
Brugia malayi Protein kinase domain containing protein 0.0453 0.4104 0.4519
Echinococcus multilocularis cyclin dependent kinase 1 0.0118 0.0779 0.0956
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0293 0.2519 0.2774
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.003
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0082 0.0419 0.0417
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0144 0.1042 0.1278
Echinococcus granulosus mitogen activated protein kinase 14 0.0159 0.1186 0.1212
Trichomonas vaginalis AGC family protein kinase 0.0154 0.1133 0.4494
Brugia malayi diacylglycerol kinase 0.0042 0.0027 0.0028
Onchocerca volvulus 0.0088 0.0478 0.0935
Entamoeba histolytica protein kinase, putative 0.0088 0.0481 0.1394
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.007 0.0077
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.005 0.0107 0.0129
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.01 0.0598 0.061
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0083 0.0435 0.126
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0122 0.0814 0.2205
Echinococcus multilocularis Glutaredoxin protein 5 0.0125 0.0852 0.1046
Echinococcus multilocularis dual specificity 0.0139 0.0983 0.1206
Echinococcus granulosus serine:threonine protein kinase 0.0072 0.0323 0.0329
Echinococcus granulosus Immunoglobulin 0.0085 0.0447 0.0455
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0276 0.2345 0.4606
Schistosoma mansoni hypothetical protein 0.0088 0.0478 0.1023
Schistosoma mansoni netrin receptor unc5 0.005 0.0098 0.0207
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0475 0.0523
Echinococcus granulosus unc 13 munc13 0.0044 0.004 0.0039
Loa Loa (eye worm) TK/EPH protein kinase 0.012 0.0796 0.0877
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0112 0.0721 0.0792
Trypanosoma brucei NIMA-related protein kinase 0.0049 0.0093 0.0247
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0082 0.0419 0.1133
Echinococcus granulosus casein kinase I alpha 0.0108 0.0677 0.0691
Loa Loa (eye worm) hypothetical protein 0.0041 0.0009 0.001
Brugia malayi Protein kinase domain containing protein 0.0087 0.0475 0.0521
Onchocerca volvulus 0.0087 0.0475 0.0929
Loa Loa (eye worm) hypothetical protein 0.0082 0.0422 0.0465
Toxoplasma gondii aurora kinase 0.0088 0.0481 0.0479
Plasmodium falciparum casein kinase 2, alpha subunit 0.0099 0.0591 0.0589
Echinococcus multilocularis 0.005 0.0107 0.0129
Echinococcus multilocularis casein kinase i 0.0108 0.0677 0.083
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0938 0.2014
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0154 0.1133 0.1391
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0145 0.0143
Echinococcus multilocularis serine:threonine protein kinase 0.0072 0.0323 0.0395
Echinococcus multilocularis mitogen activated protein kinase 0.0082 0.0426 0.0521
Echinococcus multilocularis protein kinase c eta type 0.0042 0.0027 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.1568 0.3367
Onchocerca volvulus 0.0195 0.1544 0.303
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.1352 0.5362
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0159 0.1186 0.3215
Giardia lamblia Kinase, AGC AKT 0.0116 0.0762 0.3242
Echinococcus multilocularis cyclin dependent kinase 1 0.0118 0.0779 0.0956
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0176 0.1354 0.1491
Echinococcus multilocularis protein kinase shaggy 0.0128 0.0879 0.1078
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0128 0.0879 0.0877
Loa Loa (eye worm) hypothetical protein 0.0087 0.0475 0.0523
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0605 0.1296
Onchocerca volvulus 0.0089 0.0486 0.0952
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0475 0.0523
Echinococcus granulosus dual specificity 0.0139 0.0983 0.1004
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0128 0.0879 0.2381
Plasmodium falciparum NIMA related kinase 1 0.0136 0.0954 0.0952
Brugia malayi protein kinase C3,putative 0.0157 0.1171 0.1288
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0486 0.1042
Schistosoma mansoni signal transduction protein lnk-related 0.005 0.0107 0.0225
Entamoeba histolytica cell division protein kinase 2, putative 0.0118 0.0779 0.2262
Echinococcus granulosus tyrosine protein kinase shark 0.0304 0.2629 0.2689
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0154 0.1133 0.1248
Plasmodium vivax protein kinase Crk2 0.0118 0.0779 0.0777
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0112 0.0721 0.1952
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0381 0.0379
Echinococcus granulosus peroxidasin 0.0041 0.0012 0.001
Brugia malayi serine/threonine-protein kinase PAK 7 0.0233 0.1921 0.2115
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0114 0.0742 0.0758
Trypanosoma cruzi casein kinase, putative 0.0108 0.0677 0.1833
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0044 0.0039 0.0045
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0606 0.5631 0.6202
Trypanosoma brucei cdc2-related kinase 3 0.0118 0.0779 0.2111
Trypanosoma cruzi DNA topoisomerase II, putative 0.0253 0.2123 0.576
Echinococcus granulosus tyrosine protein kinase Fyn 0.0208 0.1677 0.1715
Loa Loa (eye worm) hypothetical protein 0.0088 0.0478 0.0526
Giardia lamblia Kinase, AGC PKA 0.0156 0.1161 0.4944
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0103 0.0631 0.0644
Echinococcus multilocularis tyrosine kinase 0.0087 0.0475 0.0581
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0041 0.0009 0.001
Onchocerca volvulus 0.0089 0.0486 0.0952
Trypanosoma brucei protein kinase, putative 0.0082 0.0426 0.115
Trypanosoma brucei protein kinase, putative 0.0128 0.0879 0.2381
Onchocerca volvulus Huntingtin homolog 0.012 0.0798 0.1565
Echinococcus multilocularis activin receptor type 0.0068 0.0281 0.0344
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0721 0.2856
Echinococcus granulosus tyrosine protein kinase Src42A 0.0208 0.1677 0.1715
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0238 0.1972 0.2423
Schistosoma mansoni tyrosine kinase 0.0281 0.24 0.5156
Leishmania major protein kinase, putative 0.0068 0.0281 0.0759
Entamoeba histolytica protein kinase , putative 0.0088 0.0481 0.1394
Onchocerca volvulus 0.0087 0.0475 0.0929
Loa Loa (eye worm) thyroid receptor interactor 0.0109 0.0686 0.0755
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0381 0.0379
Giardia lamblia Kinase, NEK 0.0136 0.0954 0.4063
Echinococcus multilocularis casein kinase I alpha 0.0108 0.0677 0.083
Loa Loa (eye worm) SH2 domain-containing protein 0.005 0.0107 0.0118
Onchocerca volvulus 0.005 0.0107 0.0206
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0381 0.0379
Entamoeba histolytica serine/threonine protein kinase, putative 0.0176 0.1352 0.3929
Loa Loa (eye worm) STAT protein 0.005 0.0107 0.0118
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0153 0.1125 0.124
Echinococcus granulosus tyrosine protein kinase ABL1 0.0298 0.2566 0.2625
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0088 0.0481 0.1394
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.0376 0.0383
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0481 0.1903
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0481 0.1903
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.1046 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0591 0.2339
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0139 0.0983 0.2663
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Echinococcus granulosus aurora kinase A 0.0088 0.0481 0.049
Trypanosoma brucei aurora B kinase 0.0088 0.0481 0.1301
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0276 0.2345 0.4606
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0293 0.2519 0.3095
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0108 0.0677 0.0746
Schistosoma mansoni tyrosine kinase 0.0318 0.2768 0.5947
Echinococcus multilocularis rac serine:threonine kinase 0.0164 0.1237 0.1518
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0128 0.0879 0.0968
Loa Loa (eye worm) hypothetical protein 0.012 0.0798 0.0879
Schistosoma mansoni protein kinase 0.0438 0.3957 0.8503
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0088 0.0483 0.1306
Schistosoma mansoni tyrosine kinase 0.0238 0.1972 0.4237
Plasmodium vivax glycogen synthase kinase 3, putative 0.0128 0.0879 0.0877
Trypanosoma brucei SNF1-related protein kinases, putative 0.0088 0.0483 0.1306
Toxoplasma gondii CMGC kinase, CK2 family 0.0099 0.0591 0.0589
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0112 0.0721 0.0719
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0742 0.2939
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.008 0.0398 0.0396
Loa Loa (eye worm) TK protein kinase 0.026 0.2191 0.2414
Entamoeba histolytica protein kinase domain containing protein 0.0128 0.0879 0.2552
Loa Loa (eye worm) hypothetical protein 0.0104 0.064 0.0705
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0009 0.0008
Echinococcus granulosus tyrosine protein kinase HCK 0.0126 0.086 0.0879
Trichomonas vaginalis STE family protein kinase 0.0083 0.0435 0.172
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0258 0.2171 0.2391
Echinococcus granulosus titin 0.0059 0.0193 0.0196
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0119 0.0786 0.0964
Loa Loa (eye worm) hypothetical protein 0.0083 0.0427 0.047
Echinococcus granulosus cGMP dependent protein kinase 0.0134 0.0938 0.0959
Echinococcus multilocularis tyrosine protein kinase Abl 0.02 0.1589 0.1952
Schistosoma mansoni protein kinase 0.0085 0.0449 0.096
Echinococcus multilocularis neuroglian 0.0047 0.007 0.0083
Schistosoma mansoni tyrosine kinase 0.0069 0.029 0.0619
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0154 0.1133 0.1391
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0122 0.0814 0.2205
Trypanosoma brucei polo-like protein kinase 0.0176 0.1352 0.3666
Loa Loa (eye worm) AUR protein kinase 0.0088 0.0481 0.053
Loa Loa (eye worm) SRC-1 0.0208 0.1677 0.1847
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.0377 0.0384
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0253 0.2123 0.576
Leishmania major protein kinase, putative 0.0153 0.113 0.3064
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0118 0.0779 0.2111
Echinococcus multilocularis netrin receptor unc 5 0.005 0.0098 0.0118
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0276 0.2345 0.4606
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0093 0.0361
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0009 0.0008
Entamoeba histolytica protein kinase domain containing protein 0.0128 0.0879 0.2552
Schistosoma mansoni nck2/grb4 0.0082 0.0422 0.0903
Toxoplasma gondii DNA topoisomerase 2, putative 0.0293 0.2519 0.2518
Echinococcus granulosus tyrosine protein kinase Blk 0.0177 0.1361 0.1392
Echinococcus granulosus neuroglian 0.0047 0.007 0.0069
Brugia malayi Pleckstrin Homology Domain 0.005 0.0103 0.0112
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0208 0.1677 0.2059
Giardia lamblia Kinase, CAMK CAMKL 0.0088 0.0483 0.2052
Toxoplasma gondii NEK kinase 0.0049 0.0093 0.0091
Schistosoma mansoni protein kinase 0.0085 0.0449 0.096
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0128 0.0879 0.2381
Brugia malayi RhoGAP domain containing protein 0.0093 0.0528 0.058
Echinococcus granulosus epidermal growth factor receptor 0.0459 0.4167 0.4265
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.003
Echinococcus granulosus dual specificity 0.0122 0.0814 0.0831
Onchocerca volvulus 0.0087 0.0475 0.0929
Echinococcus multilocularis roundabout 2 0.0047 0.007 0.0083
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0159 0.1186 0.3215
Entamoeba histolytica protein kinase, putative 0.0088 0.0481 0.1394
Trichomonas vaginalis CK1 family protein kinase 0.0108 0.0677 0.2681
Echinococcus multilocularis mitogen activated protein kinase 14 0.0159 0.1186 0.1456
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0208 0.1677 0.2059
Schistosoma mansoni tyrosine kinase 0.0208 0.1677 0.3601
Echinococcus multilocularis SH2 motif 0.005 0.0107 0.0129
Echinococcus granulosus casein kinase I alpha 0.0108 0.0677 0.0691
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1022 0.9769 1
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0144 0.1042 0.1065
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0112 0.0721 0.1952
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0266 0.2246 0.2474
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0082 0.0426 0.0469
Schistosoma mansoni tensin 0.005 0.0107 0.0225
Schistosoma mansoni titin 0.0059 0.0193 0.0411
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0598 0.0733
Echinococcus multilocularis tyrosine protein kinase HCK 0.0126 0.086 0.1055
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0397 0.3556 0.437
Schistosoma mansoni GTPase activating protein 0.005 0.0107 0.0225
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0112 0.0721 0.0719
Loa Loa (eye worm) TK protein kinase 0.0177 0.1361 0.15
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.1133 0.2433
Loa Loa (eye worm) hypothetical protein 0.0041 0.0012 0.0013
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0355 0.3136 0.3209
Trypanosoma cruzi casein kinase, putative 0.0108 0.0677 0.1833
Loa Loa (eye worm) hypothetical protein 0.0468 0.4258 0.469
Brugia malayi Protein kinase domain containing protein 0.0118 0.0779 0.0856
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0144 0.1042 0.1279
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0112 0.0721 0.0884
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0118 0.0779 0.0796
Echinococcus multilocularis dual specificity 0.0139 0.0983 0.1206
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0085 0.0447 0.0547
Schistosoma mansoni vam6/vps39 related 0.0088 0.0478 0.1023
Brugia malayi Doublecortin family protein 0.0151 0.1102 0.1212
Echinococcus multilocularis SH2 domain containing protein 7 0.005 0.0107 0.0129
Giardia lamblia Kinase, CMGC CDK 0.0118 0.0779 0.3317
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0486 0.1925
Brugia malayi Protein kinase domain containing protein 0.0154 0.1133 0.1246
Trypanosoma brucei cdc2-related kinase 1 0.0118 0.0779 0.2111
Brugia malayi Protein kinase domain containing protein 0.0194 0.1535 0.1689
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0187 0.1461 0.1609
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0426 0.1683
Echinococcus granulosus Rac GTPase activating protein 1 0.0042 0.0027 0.0026
Echinococcus granulosus serine threonine protein kinase nrc 0.0156 0.1161 0.1186
Brugia malayi serine/threonine-protein kinase plk-2 0.0176 0.1352 0.1487
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0395 0.3534 0.3616
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0088 0.0478 0.0585
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0197 0.1568 0.1727
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.01 0.0598 0.061
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0047 0.007 0.0146
Schistosoma mansoni hypothetical protein 0.0072 0.0325 0.0694
Loa Loa (eye worm) hypothetical protein 0.006 0.0204 0.0225
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0397 0.3556 0.3917
Loa Loa (eye worm) hypothetical protein 0.0103 0.0631 0.0695
Loa Loa (eye worm) hypothetical protein 0.0358 0.3166 0.3487
Echinococcus multilocularis tyrosine protein kinase shark 0.0304 0.2629 0.323
Schistosoma mansoni protein kinase 0.0438 0.3957 0.8503
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0318 0.2768 0.2832
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0261 0.2202 0.22
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0082 0.0419 0.0462
Brugia malayi SRC-1 0.0208 0.1677 0.1845
Loa Loa (eye worm) hypothetical protein 0.0195 0.1544 0.17
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0081 0.0413 0.0505
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.01 0.0598 0.0596
Loa Loa (eye worm) hypothetical protein 0.0141 0.1005 0.1107
Schistosoma mansoni serine/threonine protein kinase 0.021 0.1696 0.3643
Entamoeba histolytica protein kinase, putative 0.0287 0.2456 0.7144
Trichomonas vaginalis AGC family protein kinase 0.0287 0.2456 0.975
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.01 0.0598 0.0657
Brugia malayi intracellular kinase 0.0128 0.0879 0.0966
Brugia malayi Protein kinase domain containing protein 0.0606 0.5631 0.6202
Brugia malayi Furin-like cysteine rich region family protein 0.0459 0.4167 0.4589
Loa Loa (eye worm) TK/ABL protein kinase 0.0298 0.2566 0.2826
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Entamoeba histolytica protein kinase, putative 0.008 0.0403 0.1167
Plasmodium falciparum serine/threonine protein kinase 0.0082 0.0419 0.0417
Trichomonas vaginalis STE family protein kinase 0.0085 0.0449 0.1774
Schistosoma mansoni tensin-related 0.005 0.0107 0.0225
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.021 0.1696 0.1735
Plasmodium falciparum DNA gyrase subunit A 0.1046 1 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0159 0.1186 0.3215
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0114 0.0742 0.091
Plasmodium falciparum casein kinase 1 0.0108 0.0677 0.0675
Schistosoma mansoni ephrin receptor 0.0043 0.0034 0.0069
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0085 0.0447 0.0956
Plasmodium falciparum calcium-dependent protein kinase 4 0.01 0.0598 0.0596
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0475 0.0523
Loa Loa (eye worm) hypothetical protein 0.0145 0.1046 0.1152
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0203 0.1624 0.1787
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0047 0.007 0.0083
Schistosoma mansoni diacylglycerol kinase theta 0.0042 0.0027 0.0054
Echinococcus multilocularis serine:threonine protein kinase N2 0.0285 0.2441 0.2998
Echinococcus granulosus casein kinase ii subunit alpha 0.0099 0.0591 0.0603
Brugia malayi protein kinase C II. 0.0197 0.1568 0.1725
Schistosoma mansoni tyrosine kinase 0.0281 0.24 0.5156
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0009 0.0008
Brugia malayi SH2 domain containing protein 0.005 0.0107 0.0116
Echinococcus granulosus myotubularin protein 13 0.005 0.0103 0.0104
Echinococcus granulosus casein kinase i 0.0108 0.0677 0.0691
Leishmania major protein kinase A catalytic subunit isoform 2 0.0112 0.0721 0.1952
Plasmodium falciparum calcium-dependent protein kinase 3 0.01 0.0598 0.0596
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0125 0.0852 0.1046
Schistosoma mansoni serine/threonine protein kinase 0.0481 0.4391 0.9436
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0132 0.0281
Leishmania major serine/threonine-protein kinase, putative 0.0049 0.0093 0.0247
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0483 0.1034
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0082 0.0426 0.115
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0082 0.0419 0.1133
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.021 0.1696 0.2083
Brugia malayi Fibronectin type III domain containing protein 0.0091 0.0507 0.0557
Echinococcus granulosus casein kinase I delta 0.0108 0.0677 0.0691
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0128 0.0879 0.0898
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.1967 0.4226
Loa Loa (eye worm) casein kinase 0.0183 0.1423 0.1568
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0381 0.0814
Brugia malayi SH2 domain containing protein 0.005 0.0107 0.0116
Leishmania major protein kinase, putative,serine/threonine-protein kinase Nek1, putative 0.0049 0.0093 0.0247
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0156 0.1161 0.1186
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0088 0.0481 0.1394
Plasmodium vivax DNA topoisomerase II, putative 0.0293 0.2519 0.2518
Brugia malayi Immunoglobulin I-set domain containing protein 0.0091 0.0507 0.0557
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.005 0.0107 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0419 0.0897
Plasmodium falciparum tyrosine kinase-like protein, putative 0.008 0.0398 0.0396
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0139 0.0983 0.0981
Giardia lamblia Kinase, CMGC DYRK 0.0139 0.0983 0.4185
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0879 0.3483
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0118 0.0779 0.0777
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0093 0.0528 0.0539
Trichomonas vaginalis AGC family protein kinase 0.0154 0.1133 0.4494
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0279 0.238 0.2622
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.1133 0.2433
Echinococcus granulosus protein kinase c epsilon type 0.0197 0.1568 0.1603
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0047 0.007 0.0083
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0139 0.0983 0.1082
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0009 0.0008
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0381 0.0379
Entamoeba histolytica SH2 domain containing protein 0.005 0.0107 0.0305
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0499 0.4566 0.4673
Brugia malayi Tensin 0.005 0.0107 0.0116
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0072 0.0323 0.0356
Schistosoma mansoni unc-13 (munc13) 0.0044 0.004 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.0385 0.152
Echinococcus granulosus transient receptor potential gamma protein 0.0117 0.0771 0.0787
Leishmania major mitochondrial DNA topoisomerase II 0.041 0.3685 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0118
Loa Loa (eye worm) CAMK protein kinase 0.0059 0.0193 0.0213
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0069 0.0296 0.0301
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0082 0.0426 0.115
Entamoeba histolytica protein kinase, putative 0.0279 0.238 0.6922
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0204 0.0225
Schistosoma mansoni diacylglycerol kinase theta 0.0042 0.0027 0.0054
Plasmodium vivax serine/threonine kinase-1, putative 0.0153 0.113 0.1129
Echinococcus multilocularis aurora kinase A 0.0088 0.0481 0.0589
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.005 0.0107 0.0107
Schistosoma mansoni serine/threonine-protein kinase 0.0164 0.1237 0.2655
Entamoeba histolytica hypothetical protein 0.0122 0.0814 0.2363
Plasmodium falciparum NIMA related kinase 4 0.0049 0.0093 0.0091
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0093 0.0528 0.0647
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.005 0.0107 0.0206
Echinococcus multilocularis suppressor of cytokine signaling 7 0.005 0.0107 0.0129
Echinococcus granulosus casein kinase I alpha 0.0108 0.0677 0.0691
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.1046 1 1
Brugia malayi hypothetical protein 0.0091 0.0507 0.0557
Echinococcus granulosus NDR protein kinase 0.0154 0.1133 0.1158
Echinococcus multilocularis tensin 0.005 0.0107 0.0129
Brugia malayi Protein kinase domain containing protein 0.0089 0.0486 0.0534
Leishmania major casein kinase, putative 0.0108 0.0677 0.1833
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0069 0.0295 0.0361
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Giardia lamblia Kinase, PLK 0.0176 0.1352 0.576
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0118 0.0779 0.2111
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0186 0.1455 0.16
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0131 0.0906 0.2338
Echinococcus granulosus neuroglian 0.0107 0.0665 0.0679
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.1352 0.5362
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0072 0.0326 0.0359
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0088 0.0481 0.0479
Echinococcus granulosus casein kinase I delta 0.0108 0.0677 0.0691
Echinococcus multilocularis suppressor of cytokine signaling 7 0.005 0.0107 0.0129
Trichomonas vaginalis STE family protein kinase 0.0085 0.0449 0.1774
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0112 0.0721 0.0884
Entamoeba histolytica protein kinase, putative 0.0069 0.0296 0.0855
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0042 0.0027 0.003
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0085 0.0449 0.0457
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0459 0.4165 0.4164
Echinococcus multilocularis serine:threonine protein kinase 0.0072 0.0323 0.0395
Echinococcus granulosus protein kinase 0.0153 0.1125 0.115
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0082 0.0426 0.115
Onchocerca volvulus 0.0087 0.0475 0.0929
Trichomonas vaginalis STE family protein kinase 0.0085 0.0449 0.1774
Entamoeba histolytica casein kinase, putative 0.0108 0.0677 0.1965
Brugia malayi Serine/threonine-protein kinase SULU 0.0223 0.1822 0.2005
Echinococcus multilocularis Immunoglobulin 0.0085 0.0447 0.0547
Entamoeba histolytica protein kinase, putative 0.0287 0.2456 0.7144
Echinococcus multilocularis dual specificity protein kinase clk2 0.0153 0.113 0.1388
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.01 0.0598 0.0596
Brugia malayi Protein kinase domain 0.0085 0.0449 0.0492
Brugia malayi hypothetical protein 0.0223 0.1822 0.2005
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0475 0.0523
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.005 0.0107 0.0206
Trichomonas vaginalis AGC family protein kinase 0.0287 0.2456 0.975
Trichomonas vaginalis AGC family protein kinase 0.008 0.0403 0.1593
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0053 0.0132 0.0518
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0153 0.113 0.3064
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0156 0.1161 0.3146
Echinococcus granulosus nervana 2 0.0125 0.0852 0.0871
Brugia malayi Protein kinase domain containing protein 0.0072 0.0323 0.0354
Loa Loa (eye worm) AGC/NDR protein kinase 0.0154 0.1133 0.1248
Onchocerca volvulus 0.005 0.0107 0.0206
Schistosoma mansoni hypothetical protein 0.0072 0.0325 0.0694
Leishmania major protein kinase, putative 0.01 0.0598 0.1619
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0381 0.0379
Echinococcus granulosus serine:threonine protein kinase mig 15 0.021 0.169 0.1728
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0132 0.028
Trichomonas vaginalis DNA topoisomerase II, putative 0.0293 0.2519 1
Schistosoma mansoni cell adhesion molecule 0.0041 0.0009 0.0015
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0238 0.1967 0.2417
Trypanosoma cruzi polo-like protein kinase, putative 0.0176 0.1352 0.3666
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0085 0.0449 0.0549
Echinococcus granulosus tyrosine kinase 0.0087 0.0475 0.0484
Brugia malayi map kinase activated protein kinase protein 2 0.0397 0.3556 0.3916
Trichomonas vaginalis AGC family protein kinase 0.008 0.0403 0.1593
Echinococcus granulosus hypothetical protein 0.005 0.0107 0.0107
Entamoeba histolytica protein kinase, putative 0.0139 0.0983 0.2854
Giardia lamblia Kinase, NEK 0.0049 0.0093 0.0388
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.01 0.0598 0.1619
Schistosoma mansoni protein kinase C mu 0.0042 0.0027 0.0054
Brugia malayi SH2 domain containing protein 0.005 0.0107 0.0116
Onchocerca volvulus 0.005 0.0107 0.0206
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0223 0.1822 0.2007
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0633 0.1356
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0475 0.0523
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0114 0.0137
Echinococcus granulosus suppressor of cytokine signaling 7 0.005 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0118
Chlamydia trachomatis DNA gyrase subunit B 0.0459 0.4165 0.4164
Trichomonas vaginalis CK1 family protein kinase 0.0108 0.0677 0.2681
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.1461 0.5795
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0239 0.1981 0.2182
Schistosoma mansoni DNA topoisomerase II 0.0293 0.2519 0.5413
Schistosoma mansoni hypothetical protein 0.0508 0.4653 1
Trichomonas vaginalis STE family protein kinase 0.0136 0.0954 0.3782
Brugia malayi Peroxidasin 0.0041 0.0012 0.0011
Onchocerca volvulus 0.0141 0.1005 0.1971
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0047 0.007 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.01 0.0598 0.061
Loa Loa (eye worm) SH2 domain-containing protein 0.005 0.0107 0.0118
Plasmodium falciparum calcium-dependent protein kinase 5 0.01 0.0598 0.0596
Plasmodium vivax protein kinase, putative 0.0052 0.0125 0.0124
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0119 0.0786 0.0803
Plasmodium vivax DNA gyrase subunit A, putative 0.1046 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0779 0.3088
Schistosoma mansoni serine/threonine protein kinase 0.0327 0.286 0.6144
Echinococcus multilocularis calcium activated potassium channel 0.0107 0.0672 0.0823
Schistosoma mansoni serine/threonine-protein kinase 0.0164 0.1237 0.2655
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Trypanosoma cruzi Protein kinase B 0.0164 0.1237 0.3353
Schistosoma mansoni protein kinase 0.0108 0.0677 0.1451
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0239 0.1981 0.2434
Echinococcus granulosus insulin receptor 0.0397 0.3557 0.364
Echinococcus granulosus roundabout 2 0.0047 0.007 0.0069
Echinococcus granulosus SHC transforming protein 3 0.005 0.0107 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0193 0.0411
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0983 0.3895
Echinococcus multilocularis serine:threonine protein kinase 3 0.0258 0.2171 0.2667
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0176 0.1352 0.1489
Giardia lamblia Kinase, CDC7 0.0089 0.0486 0.2067
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0083 0.0435 0.1176
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0112 0.0721 0.0884
Trichomonas vaginalis STE family protein kinase 0.0085 0.0449 0.1774
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0334 0.2923 0.3219
Brugia malayi putative serine/threonine kinase SADA gamma 0.0088 0.0483 0.053
Onchocerca volvulus 0.0327 0.286 0.5617
Brugia malayi Immunoglobulin I-set domain containing protein 0.0633 0.5897 0.6494
Brugia malayi Protein kinase domain containing protein 0.0214 0.1731 0.1905
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0059 0.0196 0.0216
Echinococcus granulosus contactin 0.0047 0.007 0.0069
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0429 0.387 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0483 0.1034
Entamoeba histolytica protein kinase, putative 0.0063 0.023 0.0664
Brugia malayi Egg laying defective protein 4 0.0134 0.0938 0.1032
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0598 0.1282
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0153 0.113 0.1245
Trypanosoma brucei Casein kinase II 0.0099 0.0591 0.1599
Brugia malayi Protein kinase domain containing protein 0.0087 0.0475 0.0521
Brugia malayi Protein kinase domain containing protein 0.0355 0.3136 0.3453
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Onchocerca volvulus 0.005 0.0107 0.0206
Echinococcus granulosus serine:threonine protein kinase 0.0072 0.0323 0.0329
Schistosoma mansoni tyrosine kinase 0.0208 0.1677 0.3601
Schistosoma mansoni suppressor of cytokine signaling 0.005 0.0107 0.0225
Loa Loa (eye worm) CDC7 protein kinase 0.0089 0.0486 0.0536
Loa Loa (eye worm) hypothetical protein 0.0104 0.064 0.0705
Echinococcus granulosus CDC7 cell division cycle 7 0.0089 0.0486 0.0496
Loa Loa (eye worm) hypothetical protein 0.0606 0.5631 0.6202
Brugia malayi Prion-like- 0.0041 0.0009 0.0008
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0153 0.113 0.3064
Trichomonas vaginalis AGC family protein kinase 0.0287 0.2456 0.975
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0047 0.007 0.0069
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0068 0.0281 0.0759
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0088 0.0478 0.1292
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0122 0.0814 0.2205
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0088 0.0483 0.0532
Echinococcus granulosus protein kinase C gamma type 0.0195 0.1546 0.1581
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0983 0.3895
Onchocerca volvulus 0.0128 0.0879 0.1723
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.2602 0.2866
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0053 0.0132 0.0146
Schistosoma mansoni tyrosine kinase 0.0397 0.3557 0.7643
Loa Loa (eye worm) hypothetical protein 0.0041 0.0009 0.001
Toxoplasma gondii AGC kinase 0.0279 0.238 0.2379
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.0814 0.1746
Loa Loa (eye worm) hypothetical protein 0.0122 0.0822 0.0906
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0591 0.2339
Echinococcus multilocularis casein kinase ii subunit alpha 0.0099 0.0591 0.0724
Toxoplasma gondii AGC kinase 0.0112 0.0721 0.0719
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0059 0.0192 0.0195
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0088 0.0483 0.0591
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0088 0.0481 0.0589
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0953 0.9079 1
Loa Loa (eye worm) TK protein kinase 0.0126 0.086 0.0948
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0153 0.113 0.3064
Entamoeba histolytica PH domain containing protein kinase, putative 0.012 0.0797 0.2315
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0208 0.1677 0.2059
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.004 0.0005 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.1352 0.5362
Loa Loa (eye worm) RasGEF domain-containing protein 0.0042 0.0027 0.003
Echinococcus granulosus nuclear factor of activated T cells 5 0.0303 0.2617 0.2677
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0132 0.028
Brugia malayi Protein kinase domain containing protein 0.0087 0.0475 0.0521
Loa Loa (eye worm) hypothetical protein 0.0358 0.3166 0.3487
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0047 0.007 0.0083
Plasmodium vivax unspecified product 0.0099 0.0591 0.0589
Echinococcus granulosus c src tyrosine kinase 0.0119 0.079 0.0807
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0591 0.2339
Echinococcus granulosus X box binding protein 1 0.0282 0.241 0.2466
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.004 0.0002 0.0002
Brugia malayi MAP kinase sur-1 0.0082 0.0426 0.0467
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0606 0.5631 0.6202
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0208 0.1677 0.1715
Loa Loa (eye worm) hypothetical protein 0.0047 0.007 0.0077
Plasmodium falciparum serine/threonine protein kinase KIN 0.0088 0.0483 0.0481
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0164 0.1236 0.1361
Echinococcus multilocularis cyclin dependent kinase 5 0.0118 0.0779 0.0956
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0404 0.3617 0.4445
Schistosoma mansoni SH2A 0.005 0.0107 0.0225
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0085 0.0449 0.0549
Echinococcus granulosus serine:threonine protein kinase N2 0.0132 0.0913 0.0933
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0118
Giardia lamblia Kinase, CK1 Casein kinase 0.0108 0.0677 0.288
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.1731 0.3719
Giardia lamblia Kinase, CMGC MAPK 0.0082 0.0426 0.1808
Schistosoma mansoni tyrosine kinase 0.0304 0.2629 0.5648
Schistosoma mansoni serine/threonine kinase 0.0154 0.1133 0.2433
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0208 0.1677 0.2059
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0009 0.0008
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0355 0.3136 0.3454
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0139 0.0983 0.2663
Echinococcus multilocularis tyrosine protein kinase Srms 0.0177 0.1361 0.1672
Loa Loa (eye worm) TOPoisomerase family member 0.0293 0.2519 0.2775
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0118 0.0779 0.0858
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0059 0.0193 0.0213
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.008 0.0403 0.0411
Mycobacterium ulcerans DNA gyrase subunit B 0.0459 0.4165 0.4164
Echinococcus multilocularis c src tyrosine kinase 0.0119 0.079 0.0969
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.005 0.0107 0.0129
Echinococcus granulosus N chimaerin 0.0093 0.0528 0.0539
Plasmodium falciparum NIMA related kinase 2 0.0049 0.0093 0.0091
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0355 0.3136 0.3453
Schistosoma mansoni roundabout 0.0041 0.0009 0.0015
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.008 0.0403 0.0493
Schistosoma mansoni vav2 0.0101 0.0605 0.1296
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0082 0.0426 0.0424
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0093 0.0361
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.01 0.0598 0.0596
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0154 0.1133 0.1158
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0088 0.0481 0.049
Loa Loa (eye worm) hypothetical protein 0.0041 0.0009 0.001
Onchocerca volvulus 0.0044 0.004 0.0075
Schistosoma mansoni tyrosine kinase 0.0254 0.2126 0.4568
Echinococcus multilocularis growth factor receptor bound protein 2 0.0082 0.0422 0.0516
Plasmodium falciparum calcium-dependent protein kinase 2 0.01 0.0598 0.0596
Trichomonas vaginalis STE family protein kinase 0.0049 0.0093 0.0361
Echinococcus multilocularis expressed conserved protein 0.0134 0.0938 0.1151
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.0377 0.0462
Echinococcus multilocularis transient receptor potential ion channel A 0.0113 0.0732 0.0898
Brugia malayi cytokine inducible SH2-containing protein 5 0.005 0.0107 0.0116
Entamoeba histolytica protein kinase, putative 0.007 0.0306 0.0886
Echinococcus multilocularis epidermal growth factor receptor 0.0459 0.4167 0.5121
Brugia malayi Probable DNA topoisomerase II 0.0293 0.2519 0.2774
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0085 0.0447 0.0956
Loa Loa (eye worm) hypothetical protein 0.0125 0.085 0.0936
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0122 0.0814 0.0896
Loa Loa (eye worm) hypothetical protein 0.0125 0.085 0.0936
Schistosoma mansoni transient receptor potential channel 0.0117 0.0771 0.1653
Entamoeba histolytica protein kinase, putative 0.0101 0.0611 0.1772
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0404 0.3617 0.3702
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0085 0.0449 0.0457
Echinococcus granulosus Vam6:Vps39 protein 0.0088 0.0478 0.0487
Brugia malayi SH2 domain containing protein 0.0395 0.3534 0.3891
Chlamydia trachomatis DNA gyrase subunit A 0.0132 0.0914 0.0913
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0118
Echinococcus granulosus transient receptor potential ion channel A 0.0113 0.0732 0.0747
Echinococcus granulosus SH2 domain containing protein 7 0.005 0.0107 0.0107
Brugia malayi Fes/CIP4 homology domain containing protein 0.0109 0.0686 0.0753
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0112 0.0721 0.0736
Loa Loa (eye worm) hypothetical protein 0.005 0.0103 0.0114
Echinococcus multilocularis roundabout 2 0.0131 0.0911 0.1117
Schistosoma mansoni cell adhesion molecule 0.0047 0.007 0.0146
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0093 0.0528 0.1132
Schistosoma mansoni hypothetical protein 0.005 0.0107 0.0225
Trichomonas vaginalis AGC family protein kinase 0.0287 0.2456 0.975
Brugia malayi Protein kinase domain containing protein 0.0183 0.1421 0.1563
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.0376 0.046
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0779 0.3088
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.1455 0.3124
Toxoplasma gondii diacylglycerol kinase, putative 0.0042 0.0027 0.0025
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.005 0.0107 0.0107
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0088 0.0483 0.1306
Brugia malayi STE20-like kinase MST 0.0258 0.2171 0.239
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0088 0.0478 0.1023
Entamoeba histolytica serine/threonine protein kinase, putative 0.0088 0.0483 0.14
Brugia malayi SH2 domain containing protein 0.005 0.0107 0.0116
Trichomonas vaginalis AGC family protein kinase 0.0136 0.0954 0.3782
Echinococcus multilocularis Immunoglobulin 0.0085 0.0447 0.0547
Echinococcus granulosus protein kinase c iota type 0.028 0.2391 0.2446
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0113 0.0122
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0238 0.1972 0.2423
Onchocerca volvulus Netrin receptor homolog 0.0053 0.0132 0.0256
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0044 0.004 0.0039
Echinococcus granulosus roundabout 2 0.0131 0.0911 0.0931
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0083 0.0435 0.126
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0041 0.0009 0.0015
Brugia malayi protein unc-22 0.0059 0.0193 0.0211
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0053 0.0132 0.0144
Echinococcus granulosus dual specificity 0.0139 0.0983 0.1004
Brugia malayi hypothetical protein 0.012 0.0798 0.0877
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0119 0.079 0.1694
Echinococcus granulosus dual specificity protein kinase clk2 0.0153 0.113 0.1156
Giardia lamblia Kinase, STE STE20 0.0085 0.0449 0.1906
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0093 0.0528 0.0582
Onchocerca volvulus 0.0087 0.0475 0.0929
Loa Loa (eye worm) hypothetical protein 0.0121 0.0805 0.0887
Echinococcus granulosus tyrosine protein kinase Lyn 0.0239 0.1985 0.203
Echinococcus multilocularis myotubularin protein 13 0.005 0.0103 0.0125
Trypanosoma cruzi p21-activated kinase 3, putative 0.0053 0.0132 0.0354
Brugia malayi SH2 domain containing protein 0.005 0.0107 0.0116
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0253 0.2123 0.576
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0164 0.1236 0.1263
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0598 0.2368
Echinococcus granulosus tyrosine protein kinase Fyn 0.0208 0.1677 0.1715
Echinococcus granulosus cGMP dependent protein kinase 1 0.0134 0.0938 0.0959
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0164 0.1237 0.3353
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0426 0.0911
Entamoeba histolytica PH domain containing protein kinase, putative 0.0164 0.1237 0.3594
Echinococcus multilocularis geminin 0.0508 0.4653 0.5718
Leishmania major protein kinase, putative 0.0049 0.0093 0.0247
Loa Loa (eye worm) protein kinase domain-containing protein 0.0214 0.1731 0.1907
Echinococcus granulosus growth factor receptor bound protein 2 0.0084 0.0442 0.0451
Echinococcus multilocularis death associated protein kinase 1 0.0858 0.8135 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0175 0.0192
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0193 0.1525 0.168
Loa Loa (eye worm) AGC/PKA protein kinase 0.0112 0.0721 0.0794
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0591 0.2339
Loa Loa (eye worm) hypothetical protein 0.0088 0.0478 0.0526
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0154 0.1133 0.1158
Trypanosoma cruzi cdc2-related kinase 1 0.0118 0.0779 0.2111
Echinococcus multilocularis transient receptor potential gamma protein 0.0117 0.0771 0.0945
Loa Loa (eye worm) hypothetical protein 0.0072 0.0325 0.0358
Echinococcus granulosus ephrin type A receptor 4 A 0.0102 0.0619 0.0632
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0118 0.0779 0.0858
Entamoeba histolytica diacylglycerol kinase, putative 0.0042 0.0027 0.0074
Echinococcus multilocularis insulin receptor 0.0397 0.3557 0.4371
Schistosoma mansoni protein kinase 0.0153 0.1125 0.2416
Trypanosoma cruzi casein kinase II, putative 0.0099 0.0591 0.1599
Schistosoma mansoni hypothetical protein 0.0282 0.241 0.5178
Loa Loa (eye worm) hypothetical protein 0.012 0.0798 0.0879
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0153 0.113 0.3064
Giardia lamblia Kinase, CMGC CK2 0.0099 0.0591 0.2513
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0068 0.0281 0.0759
Echinococcus multilocularis lachesin 0.0041 0.0009 0.0009
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0112 0.0721 0.1952
Echinococcus granulosus TRP transient receptor potential channel 0.0044 0.0039 0.0038
Giardia lamblia Kinase, AGC PKA 0.0112 0.0721 0.3068
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0118
Plasmodium vivax DNA gyrase subunit B, putative 0.0459 0.4165 0.4164
Brugia malayi serine/threonine kinase 12 0.0088 0.0481 0.0528
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0059 0.0192 0.0234
Echinococcus granulosus dual specificity 0.0139 0.0983 0.1004
Brugia malayi hypothetical protein 0.0057 0.0175 0.019
Trypanosoma cruzi casein kinase, putative 0.0108 0.0677 0.1833
Trichomonas vaginalis AGC family protein kinase 0.0161 0.121 0.4797
Echinococcus multilocularis mitogen activated protein kinase 14 0.0159 0.1186 0.1456
Entamoeba histolytica cell division protein kinase 2, putative 0.0118 0.0779 0.2262
Loa Loa (eye worm) hypothetical protein 0.0085 0.0447 0.0492
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0156 0.1161 0.1159
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0139 0.0983 0.2663
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0201 0.1605 0.1642
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0088 0.0478 0.1292
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0078 0.0378 0.0416
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0438 0.3957 0.4049
Onchocerca volvulus 0.0187 0.1467 0.288
Echinococcus granulosus raf serine:threonine protein kinase 0.0079 0.0395 0.0403
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.1033 0.2217
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0177 0.1361 0.1672
Plasmodium falciparum glycogen synthase kinase 3 0.0128 0.0879 0.0877
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0293 0.2519 0.2774
Schistosoma mansoni tensin 0.005 0.0107 0.0225
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0426 0.1683
Brugia malayi casein kinase I 0.0108 0.0677 0.0744
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0475 0.0523
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.01 0.0598 0.0596
Echinococcus granulosus cyclin dependent kinase 0.0118 0.0779 0.0796
Schistosoma mansoni protein kinase 0.0068 0.0281 0.0601
Schistosoma mansoni rap gtpase-activating protein 0.0088 0.0478 0.1023
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0144 0.1042 0.1279
Schistosoma mansoni tyrosine kinase 0.0225 0.184 0.3951
Brugia malayi serine/threonine protein kinase 6 0.0088 0.0481 0.0528
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0099 0.0591 0.0589
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0203 0.1624 0.1995
Brugia malayi Variant SH3 domain containing protein 0.0059 0.0196 0.0214
Brugia malayi SH2 domain containing protein 0.005 0.0107 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0633 0.1356
Echinococcus multilocularis N chimaerin 0.0093 0.0528 0.0647
Echinococcus granulosus protein kinase c eta type 0.0042 0.0027 0.0026
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0088 0.0483 0.1306
Schistosoma mansoni neuroglian 0.0047 0.007 0.0146
Echinococcus multilocularis Rac GTPase activating protein 1 0.0042 0.0027 0.0031
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0208 0.1677 0.2059
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.005 0.0107 0.0225
Entamoeba histolytica protein kinase 2, putative 0.0156 0.1161 0.3372
Loa Loa (eye worm) hypothetical protein 0.0183 0.1427 0.1571
Echinococcus granulosus expressed protein 0.0082 0.0419 0.0427
Loa Loa (eye worm) hypothetical protein 0.0117 0.0773 0.0851
Loa Loa (eye worm) hypothetical protein 0.0145 0.1046 0.1152
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0116 0.0762 0.0837
Trichomonas vaginalis AGC family protein kinase 0.0154 0.1133 0.4494
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0112 0.0721 0.1952
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.005 0.0107 0.0107
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0128 0.0879 0.1078
Echinococcus multilocularis titin 0.0059 0.0193 0.0235
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.1352 0.5362
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0093 0.0195
Trypanosoma cruzi casein kinase, putative 0.0108 0.0677 0.1833
Schistosoma mansoni tyrosine-protein kinase zap-70 0.005 0.0107 0.0225
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0938 0.2014
Schistosoma mansoni protein kinase 0.0068 0.0281 0.0601
Entamoeba histolytica protein kinase domain containing protein 0.004 0.0005 0.001
Schistosoma mansoni transient receptor potential channel 0.0078 0.0376 0.0805
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0266 0.2246 0.2759
Schistosoma mansoni adapter molecule crk 0.0082 0.0422 0.0903
Schistosoma mansoni nephrin 0.0047 0.007 0.0146
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.005 0.0107 0.0129
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0238 0.1972 0.2018
Schistosoma mansoni protein kinase 0.0088 0.0481 0.103
Toxoplasma gondii NEK kinase 0.0049 0.0093 0.0091
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0053 0.0132 0.0354
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0108 0.0677 0.0746
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0112 0.0721 0.1952
Loa Loa (eye worm) SH2 domain-containing protein 0.005 0.0107 0.0118
Onchocerca volvulus Serine\/threonine kinase homolog 0.0176 0.1352 0.2653
Brugia malayi Cam kinase protein 1 0.01 0.0598 0.0657
Entamoeba histolytica protein kinase, putative 0.007 0.0306 0.0886
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.01 0.0598 0.0596
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0093 0.0528 0.1132
Schistosoma mansoni protein kinase 0.0063 0.023 0.049
Trypanosoma cruzi cdc2-related kinase 3 0.0118 0.0779 0.2111
Echinococcus granulosus SH2 motif 0.005 0.0107 0.0107
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0041 0.0009 0.0009
Entamoeba histolytica protein kinase, putative 0.01 0.0598 0.1735
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0296 0.0632
Echinococcus multilocularis Diacylglycerol kinase theta 0.0042 0.0027 0.0031
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0164 0.1236 0.1517
Loa Loa (eye worm) hypothetical protein 0.0117 0.0771 0.0849
Echinococcus multilocularis protein kinase c epsilon type 0.0197 0.1568 0.1925
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0186 0.1455 0.1602
Loa Loa (eye worm) hypothetical protein 0.0041 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0112 0.0721 0.0794
Plasmodium falciparum protein kinase 5 0.0118 0.0779 0.0777
Echinococcus multilocularis tyrosine protein kinase otk 0.0041 0.0009 0.0009
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0156 0.1161 0.1425
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0088 0.0483 0.1306
Brugia malayi STAT protein, DNA binding domain containing protein 0.005 0.0107 0.0116
Schistosoma mansoni tensin-related 0.005 0.0107 0.0225
Echinococcus multilocularis epidermal growth factor receptor 0.0318 0.2768 0.3401
Schistosoma mansoni protein kinase 0.0438 0.3957 0.8503
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0499 0.4566 0.5612
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0204 0.0223
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0118 0.0779 0.0858
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0053 0.0132 0.0146
Trypanosoma brucei protein kinase, putative 0.0068 0.0281 0.0759
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0403 0.0862
Entamoeba histolytica protein kinase domain containing protein 0.0088 0.0481 0.1394
Trichomonas vaginalis CK1 family protein kinase 0.0108 0.0677 0.2681
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0983 0.3895
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0209 0.0446
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0049 0.0093 0.0247
Schistosoma mansoni serine/threonine kinase 0.0187 0.1461 0.3137
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0125 0.0852 0.0871
Schistosoma mansoni unc-13 (munc13) 0.0044 0.004 0.0082
Loa Loa (eye worm) hypothetical protein 0.0091 0.0506 0.0557
Brugia malayi Protein kinase domain containing protein 0.0154 0.1133 0.1246
Plasmodium vivax calcium-dependent protein kinase, putative 0.01 0.0598 0.0596
Brugia malayi diacylglycerol kinase 0.0042 0.0027 0.0028
Plasmodium falciparum DNA topoisomerase 2 0.0293 0.2519 0.2518
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0176 0.1352 0.3666
Giardia lamblia Kinase, NEK 0.0136 0.0954 0.4063
Entamoeba histolytica protein kinase, putative 0.0085 0.0449 0.13
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Schistosoma mansoni hypothetical protein 0.0508 0.4653 1
Giardia lamblia Kinase, STE STE20 0.0083 0.0435 0.1848
Brugia malayi protein-tyrosine kinase 0.0177 0.1361 0.1498
Schistosoma mansoni tyrosine kinase 0.0247 0.2065 0.4435
Schistosoma mansoni vesicular amine transporter 0.0089 0.0486 0.104
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0118
Onchocerca volvulus 0.0296 0.2551 0.5011
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0186 0.1455 0.1487
Echinococcus multilocularis expressed protein 0.0082 0.0419 0.0513
Schistosoma mansoni hypothetical protein 0.005 0.0107 0.0225
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0218 0.1776 0.1956
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0983 0.3895
Echinococcus multilocularis twitchin 0.0053 0.0132 0.0161
Brugia malayi Variant SH3 domain containing protein 0.0082 0.0422 0.0463
Loa Loa (eye worm) hypothetical protein 0.0294 0.2533 0.279
Loa Loa (eye worm) hypothetical protein 0.0088 0.0483 0.0532
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0128 0.0879 0.0968
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0118
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.01 0.0598 0.0596
Schistosoma mansoni ephrin receptor 0.0102 0.0619 0.1327
Echinococcus granulosus signal transduction protein lnk realted 0.005 0.0107 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.0201 0.1606 0.3448
Echinococcus multilocularis mitogen activated protein kinase 11 0.0159 0.1186 0.1456
Brugia malayi Protein kinase domain containing protein 0.0082 0.0419 0.046
Giardia lamblia Kinase, CMGC CDK 0.0118 0.0779 0.3317
Brugia malayi Protein kinase domain containing protein 0.0062 0.0222 0.0242
Entamoeba histolytica protein kinase, putative 0.0069 0.0296 0.0855
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0486 0.1925
Loa Loa (eye worm) TK/ROR protein kinase 0.0059 0.0192 0.0212
Brugia malayi Protein kinase domain containing protein 0.0187 0.1461 0.1607
Loa Loa (eye worm) AGC/AKT protein kinase 0.0287 0.2456 0.2706
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0483 0.1034
Echinococcus granulosus tyrosine protein kinase Src64B 0.0208 0.1677 0.1715
Mycobacterium ulcerans DNA gyrase subunit A 0.1046 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0721 0.1546
Trypanosoma cruzi polo-like protein kinase, putative 0.0176 0.1352 0.3666
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0293 0.2519 0.2578
Brugia malayi casein kinase 1, delta 0.0108 0.0677 0.0744
Echinococcus multilocularis X box binding protein 1 0.0282 0.241 0.2961
Loa Loa (eye worm) TK/INSR protein kinase 0.0397 0.3557 0.3918
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0153 0.113 0.3064
Echinococcus multilocularis signal transduction protein lnk realted 0.005 0.0107 0.0129
Trypanosoma cruzi Serine/threonine-protein kinase NEK16, putative 0.0049 0.0093 0.0247
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0112 0.0721 0.0736
Echinococcus multilocularis SH2 motif 0.005 0.0107 0.0129
Brugia malayi probable protein kinase 0.0241 0.1998 0.2199
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0598 0.0733
Echinococcus granulosus Protein kinase C brain isozyme 0.0238 0.1967 0.2013
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0254 0.2135 0.2184
Loa Loa (eye worm) hypothetical protein 0.0163 0.1224 0.1348
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.0442 0.0946
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0591 0.2339
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0742 0.2939
Onchocerca volvulus Huntingtin homolog 0.012 0.0798 0.1565
Loa Loa (eye worm) hypothetical protein 0.0091 0.0506 0.0557
Leishmania major protein kinase, putative 0.0083 0.0435 0.1176
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.1352 0.5362
Loa Loa (eye worm) hypothetical protein 0.0163 0.1224 0.1348
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0118
Loa Loa (eye worm) hypothetical protein 0.0146 0.1053 0.116
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.01 0.0598 0.0659
Schistosoma mansoni ste20-related kinase 0.0206 0.165 0.3543
Echinococcus multilocularis SH2 motif 0.005 0.0107 0.0129
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0082 0.0422 0.0903
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0475 0.0523
Plasmodium falciparum calcium-dependent protein kinase 1 0.01 0.0598 0.0596
Leishmania major protein kinase, putative 0.0153 0.113 0.3064
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0134 0.0938 0.0937
Trypanosoma brucei DNA topoisomerase ii 0.041 0.3685 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0208 0.1677 0.2059
Echinococcus multilocularis serine:threonine protein kinase 38 0.0154 0.1133 0.1391
Brugia malayi Tyrosine-protein kinase abl-1 0.02 0.1589 0.1749
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0483 0.1034
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0395 0.0845
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0112 0.0721 0.0736
Loa Loa (eye worm) hypothetical protein 0.0078 0.0381 0.0419
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.1046 1 1
Giardia lamblia Kinase, CMGC CLK 0.0153 0.113 0.4816
Echinococcus granulosus serine/threonine protein kinase 0.0164 0.1237 0.1264
Toxoplasma gondii casein kinase I 0.0108 0.0677 0.0675
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0721 0.1546
Brugia malayi p70 ribosomal S6 kinase beta 0.0279 0.238 0.262
Brugia malayi Variant SH3 domain containing protein 0.0093 0.0528 0.058
Loa Loa (eye worm) raf kinase 0.0042 0.0027 0.003
Onchocerca volvulus Serine\/threonine kinase homolog 0.0164 0.1236 0.2425
Echinococcus multilocularis 0.0129 0.0888 0.109
Brugia malayi Protein kinase domain containing protein 0.0287 0.2456 0.2704
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0088 0.0481 0.1394
Trypanosoma cruzi cdc2-related kinase 1 0.0118 0.0779 0.2111
Echinococcus multilocularis casein kinase I gamma 0.0214 0.1731 0.2126
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0081 0.0413 0.0421
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0069 0.0296 0.0361
Echinococcus multilocularis nervana 2 0.0125 0.0852 0.1046
Plasmodium vivax serine/threonine-protein kinase NEK4, putative 0.0049 0.0093 0.0091
Echinococcus granulosus fibroblast growth factor receptor 4 0.0238 0.1972 0.2018
Loa Loa (eye worm) TK/EGFR protein kinase 0.0459 0.4167 0.459
Loa Loa (eye worm) hypothetical protein 0.0041 0.0009 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0481 0.103
Echinococcus granulosus snurportin 1 0.0301 0.2602 0.2662
Entamoeba histolytica casein kinase, putative 0.0099 0.0591 0.1714
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0112 0.0721 0.0884
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0044 0.004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0085 0.0447 0.0492
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0114 0.0289
Echinococcus multilocularis casein kinase I delta 0.0108 0.0677 0.083
Loa Loa (eye worm) hypothetical protein 0.021 0.169 0.1861
Schistosoma mansoni hypothetical protein 0.0041 0.0015 0.0027
Echinococcus granulosus roundabout 2 0.0047 0.007 0.0069
Brugia malayi Protein kinase domain containing protein 0.0193 0.1525 0.1678
Echinococcus multilocularis cyclin dependent kinase 0.0118 0.0779 0.0956
Loa Loa (eye worm) hypothetical protein 0.0044 0.0039 0.0043
Echinococcus multilocularis serine:threonine protein kinase N2 0.0154 0.1133 0.1391
Onchocerca volvulus 0.0063 0.0229 0.0446
Echinococcus multilocularis neuroglian 0.0107 0.0665 0.0816
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.008 0.0403 0.0444
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0381 0.0379
Echinococcus multilocularis dual specificity 0.0139 0.0983 0.1206
Loa Loa (eye worm) hypothetical protein 0.0065 0.0251 0.0276
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0122 0.0814 0.2205
Echinococcus multilocularis NCK adaptor protein 0.0084 0.0442 0.0541
Leishmania major protein kinase A catalytic subunit 0.0112 0.0721 0.1952
Loa Loa (eye worm) hypothetical protein 0.0074 0.0337 0.0372
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0112 0.0721 0.1952
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0124 0.0838 0.227
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.1046 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0177 0.1361 0.1672
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0208 0.1677 0.2059
Brugia malayi cell division control protein 2 homolog 0.0118 0.0779 0.0856
Leishmania major DNA topoisomerase ii 0.0253 0.2123 0.576
Echinococcus granulosus calcium activated potassium channel 0.0107 0.0672 0.0686
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0983 0.2109
Toxoplasma gondii NEK kinase 0.0049 0.0093 0.0091
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0108 0.0677 0.0746
Giardia lamblia Kinase, CMGC GSK 0.0128 0.0879 0.3741
Brugia malayi hypothetical protein 0.005 0.0107 0.0116
Onchocerca volvulus 0.0087 0.0475 0.0929
Echinococcus multilocularis protein kinase c iota type 0.028 0.2391 0.2937
Echinococcus granulosus mitogen activated protein kinase 11 0.0159 0.1186 0.1212
Brugia malayi Protein kinase domain containing protein 0.0087 0.0475 0.0521
Echinococcus multilocularis PAK box P21 Rho binding 0.0063 0.023 0.028
Schistosoma mansoni transient receptor potential channel 4 0.0117 0.0771 0.1653
Onchocerca volvulus Tyrosine kinase homolog 0.0552 0.509 1
Mycobacterium ulcerans hypothetical protein 0.0103 0.063 0.0629
Trichomonas vaginalis AGC family protein kinase 0.008 0.0403 0.1593
Plasmodium falciparum serine/threonine protein kinase, putative 0.0088 0.0481 0.0479
Echinococcus multilocularis casein kinase I delta 0.0108 0.0677 0.083
Trichomonas vaginalis AGC family protein kinase 0.0287 0.2456 0.975
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0082 0.0426 0.115
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0483 0.191
Entamoeba histolytica protein kinase, putative 0.0128 0.0879 0.2552
Trichomonas vaginalis STE family protein kinase 0.0063 0.023 0.0906
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0159 0.1186 0.1306
Giardia lamblia Aurora kinase 0.0088 0.0481 0.2044
Schistosoma mansoni suppressor of cytokine signaling 0.005 0.0107 0.0225
Entamoeba histolytica tyrosin kinase, putative 0.004 0.0005 0.001

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 1.884 uM PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that inhibit transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2247, AID2256] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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