Detailed information for compound 1335793

Basic information

Technical information
  • TDR Targets ID: 1335793
  • Name: ethyl 4-oxo-6-phenyl-3-(phenylmethyl)-1,5,6,7 -tetrahydroindole-2-carboxylate
  • MW: 373.444 | Formula: C24H23NO3
  • H donors: 1 H acceptors: 2 LogP: 4.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1[nH]c2c(c1Cc1ccccc1)C(=O)CC(C2)c1ccccc1
  • InChi: 1S/C24H23NO3/c1-2-28-24(27)23-19(13-16-9-5-3-6-10-16)22-20(25-23)14-18(15-21(22)26)17-11-7-4-8-12-17/h3-12,18,25H,2,13-15H2,1H3
  • InChiKey: PWAIIYWTEJEUDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-oxo-6-phenyl-3-(phenylmethyl)-1,5,6,7-tetrahydroindole-2-carboxylic acid ethyl ester
  • 3-(benzyl)-4-keto-6-phenyl-1,5,6,7-tetrahydroindole-2-carboxylic acid ethyl ester
  • C276-0868
  • NCGC00106939-01
  • IVK/2008878

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cytochrome p450-like protein 0.0023 0.0035 0.1012
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.006
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0048 0.0157
Echinococcus multilocularis Ankyrin 0.0016 0.0016 0.007
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0035 0.1012
Echinococcus multilocularis GPCR, family 2 0.0019 0.0025 0.0111
Loa Loa (eye worm) hypothetical protein 0.0041 0.0086 0.0511
Echinococcus multilocularis mitogen activated protein kinase 14 0.0136 0.0348 0.1537
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0023 0.0035 0.0315
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0012 0.0055
Plasmodium falciparum epoxide hydrolase 1 0.0041 0.0085 0.7258
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0008 0.0048
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0028 0.243
Loa Loa (eye worm) calpain family protein 1 0.0049 0.0107 0.0635
Brugia malayi nuclear hormone receptor 0.0027 0.0048 0.0283
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0023 0.0035 0.0315
Brugia malayi hypothetical protein 0.0052 0.0117 0.0695
Brugia malayi nuclear receptor NHR-88 0.0027 0.0048 0.0283
Loa Loa (eye worm) sugar transporter 0.0052 0.0117 0.0695
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.001 0.0122
Brugia malayi hypothetical protein 0.0176 0.0456 0.271
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0043 0.0256
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0838 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0076 0.6526
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0185 0.5307
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0255 0.3045
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0255 0.3045
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0025 0.0083
Brugia malayi TAR-binding protein 0.0076 0.0183 0.1088
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.001 0.0034
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0052 0.0117 0.1047
Onchocerca volvulus Putative transporter 0.0052 0.0117 0.1734
Onchocerca volvulus 0.002 0.0028 0.0421
Trypanosoma cruzi kinesin, putative 0.0021 0.003 0.085
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0088 0.7566
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0028 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0117 0.1396
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0099 0.8465
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.001 0.0122
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0086 0.0511
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0015 0.0015 0.0428
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0043 0.0385
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0012 0.0041
Leishmania major myo-inositol/proton symporter (MIT) 0.0052 0.0117 0.3362
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0023 0.0035 0.0035
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0015 0.0091
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0008 0.0036
Leishmania major ABC-thiol transporter 0.0015 0.0015 0.0428
Entamoeba histolytica ABC transporter, putative 0.0015 0.0015 0.0178
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0001 0.0042
Brugia malayi Major Facilitator Superfamily protein 0.0052 0.0117 0.0695
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0048 0.0283
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0048 0.0157
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0043 0.1237
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0339
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0048 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0339
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0048 0.021
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0048 0.0706
Brugia malayi hypothetical protein 0.0014 0.0012 0.0073
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0048 0.0283
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0073
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.003 0.085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0339
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0695
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Brugia malayi Cytochrome P450 family protein 0.0023 0.0035 0.0209
Onchocerca volvulus 0.0052 0.0117 0.1734
Mycobacterium ulcerans sugar transporter 0.0052 0.0117 0.1047
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.001 0.0122
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0185 0.5307
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0008 0.0036
Schistosoma mansoni hypothetical protein 0.0015 0.0015 0.0068
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.0191 0.0628
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0048
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0043 0.1237
Entamoeba histolytica cysteine protease, putative 0.002 0.0028 0.0339
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0061 0.4859
Chlamydia trachomatis replicative DNA helicase 0.0416 0.1116 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0048 0.0157
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0169
Brugia malayi hypoxia-induced factor 1 0.0162 0.0418 0.2487
Trypanosoma brucei glucose transporter 2A 0.0052 0.0117 0.3362
Brugia malayi nuclear receptor NHR-67 0.0013 0.0008 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0185 0.5307
Schistosoma mansoni hypothetical protein 0.0347 0.0926 0.4093
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0094
Brugia malayi ecdysteroid receptor 0.0027 0.0048 0.0283
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0052 0.0117 0.0385
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0283
Brugia malayi calpain 7 0.0021 0.003 0.0176
Onchocerca volvulus 0.0039 0.0079 0.1178
Treponema pallidum replicative DNA helicase (dnaB) 0.0416 0.1116 1
Toxoplasma gondii transporter, major facilitator family protein 0.0052 0.0117 0.9287
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0126 0.0415
Brugia malayi hypothetical protein 0.0052 0.0117 0.0695
Onchocerca volvulus 0.0052 0.0117 0.1734
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0018
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0025 0.015
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0015 0.0015 0.0428
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.003 0.085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0008 0.0036
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.003 0.085
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0079 0.0472
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0008 0.0036
Leishmania major basic transcription factor 3a, putative 0.0038 0.0076 0.2194
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0048 0.0283
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0116 0.0292 0.0874
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0035 0.0209
Mycobacterium leprae Conserved hypothetical protein 0.1227 0.3344 1
Onchocerca volvulus 0.0052 0.0117 0.1734
Loa Loa (eye worm) acetyltransferase 0.0156 0.0402 0.2388
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0023 0.0035 0.0035
Trypanosoma brucei glucose transporter, putative 0.0052 0.0117 0.3362
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0012 0.0073
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0695
Plasmodium vivax unspecified product 0.001 0.0001 0.0126
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0183 0.0809
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0099 0.1181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0185 0.5307
Onchocerca volvulus 0.0255 0.0674 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0048 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0117 0.1396
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0126 0.1503
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.015
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Trypanosoma cruzi hexose transporter, putative 0.0052 0.0117 0.3362
Schistosoma mansoni sugar transporter 0.0052 0.0117 0.0517
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0224 0.0589 0.35
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0001 0.0005
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0043 0.0513
Entamoeba histolytica calpain large subunit domain III containing protein 0.0021 0.003 0.0353
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0185 0.5307
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0126 0.362
Schistosoma mansoni calpain-7 (C02 family) 0.0024 0.0038 0.017
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0089
Trypanosoma brucei polo-like protein kinase 0.0103 0.0255 0.7335
Brugia malayi small heat shock protein 0.0622 0.1682 1
Giardia lamblia ABC transporter, putative 0.0015 0.0015 0.0178
Schistosoma mansoni hypothetical protein 0.0347 0.0926 0.4093
Giardia lamblia Kinase, PLK 0.0103 0.0255 0.3045
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0255 0.3045
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0023 0.0035 0.0035
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.001 0.0295
Plasmodium vivax SET domain protein, putative 0.0032 0.0061 0.5232
Trypanosoma brucei glucose transporter 1E 0.0052 0.0117 0.3362
Schistosoma mansoni hypothetical protein 0.0019 0.0025 0.0111
Trypanosoma cruzi hexose transporter, putative 0.0052 0.0117 0.3362
Echinococcus multilocularis calpain 5 0.0021 0.003 0.0131
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0136 0.0348 0.2068
Leishmania major protein kinase, putative 0.0019 0.0025 0.0731
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0008 0.012
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Loa Loa (eye worm) hypothetical protein 0.0069 0.0163 0.0972
Brugia malayi MH2 domain containing protein 0.0116 0.0291 0.1732
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0022 0.0022
Brugia malayi N-terminal motif family protein 0.0194 0.0507 0.3014
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0126 0.0415
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0283
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0185 0.5307
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0058 0.0191
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.001 0.0122
Onchocerca volvulus 0.0052 0.0117 0.1734
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0052 0.0117 0.0517
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0089
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0822
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0048 0.021
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0025 0.0111
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0023 0.0035 0.0315
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0838 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0023 0.0035 0.0315
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0028 0.0094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0048 0.021
Giardia lamblia Hexose transporter 0.0052 0.0117 0.1396
Brugia malayi PAS domain containing protein 0.0052 0.0117 0.0694
Entamoeba histolytica cysteine proteinase 2 0.001 0.0001 0.0018
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0016 0.0016 0.0047
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0008 0.012
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0025 0.0025
Echinococcus multilocularis conserved hypothetical protein 0.0743 0.2015 0.8904
Plasmodium falciparum hexose transporter 0.0052 0.0117 1
Brugia malayi nuclear receptor NHR-88 0.0013 0.0008 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0048 0.0283
Schistosoma mansoni glucose transport protein 0.0052 0.0117 0.0517
Brugia malayi tailless protein 0.0013 0.0008 0.0048
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0339
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0043 0.0513
Brugia malayi major facilitator superfamily protein 0.0052 0.0117 0.0695
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0183 0.0809
Schistosoma mansoni calpain C (C02 family) 0.0021 0.003 0.0131
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0014 0.04
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0061 0.027
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0015 0.0068
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0018
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Brugia malayi ecdysone receptor 0.0013 0.0008 0.0048
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0025 0.0226
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0099 0.7861
Plasmodium falciparum cysteine proteinase falcipain 1 0.001 0.0001 0.0126
Toxoplasma gondii facilitative glucose transporter GT1 0.0052 0.0117 0.9287
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0339
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0099 0.0326
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0166 0.4779
Plasmodium vivax vivapain-3 0.001 0.0001 0.0126
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0048 0.0283
Giardia lamblia Fructose-bisphosphate aldolase 0.0315 0.0838 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0023 0.0035 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0185 0.5307
Mycobacterium leprae Possible regulatory protein 0.0014 0.001 0.0031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0117 0.1396
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0048
Trypanosoma brucei glucose transporter, putative 0.0052 0.0117 0.3362
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0035 0.0209
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0043 0.0043
Entamoeba histolytica ATP-binding cassette protein, putative 0.0015 0.0015 0.0178
Onchocerca volvulus 0.0052 0.0117 0.1734
Loa Loa (eye worm) hypoxia-induced factor 1 0.0162 0.0418 0.2487
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0073
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0126 0.0749
Loa Loa (eye worm) hypothetical protein 0.004 0.0082 0.0489
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.003 0.085
Schistosoma mansoni hypothetical protein 0.0019 0.0025 0.0111
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0291 0.1732
Onchocerca volvulus 0.0029 0.0053 0.0781
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0043 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0001 0.0042
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3349 0.9176 0.9176
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0001 0.0042
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0028 0.0169
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0082 0.2366
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0082 0.0982
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.003 0.085
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0014 0.04
Onchocerca volvulus 0.0052 0.0117 0.1734
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0048 0.0157
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0088 0.1056
Trypanosoma brucei protein kinase, putative 0.0056 0.0126 0.362
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0283
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0012 0.0055
Schistosoma mansoni multidrug resistance protein 0.0015 0.0015 0.0066
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0008 0.0036
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0154 0.0507
Schistosoma mansoni coup transcription factor 0.0027 0.0048 0.021
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Echinococcus granulosus mitogen activated protein kinase 11 0.0136 0.0348 0.1145
Brugia malayi hypothetical protein 0.0071 0.0168 0.0999
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0136 0.0348 1
Echinococcus granulosus multidrug resistance associated protein 1 0.0015 0.0015 0.0049
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.001 0.012
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0256
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0069 0.0304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0048 0.0283
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0131 0.078
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0022 0.0022
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0048 0.021
Schistosoma mansoni Replicative DNA helicase 0.0416 0.1116 0.4933
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0011 0.0037
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0073 0.0173 0.057
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0023 0.0035 0.0035
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0016 0.014
Giardia lamblia Multidrug resistance-associated protein 1 0.0015 0.0015 0.0178
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0048 0.0157
Loa Loa (eye worm) ctsf protein 0.002 0.0028 0.0169
Trypanosoma brucei antigen, putative 0.0021 0.003 0.085
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0001 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.001 0.012
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0048 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0339
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0052 0.0117 0.0385
Brugia malayi cathepsin L-like precursor 0.0014 0.001 0.006
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.0255 0.7335
Echinococcus multilocularis transcription factor btf3 0.0038 0.0076 0.0337
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2263 0.7453
Loa Loa (eye worm) DR-78 0.0013 0.0008 0.0048
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0028 0.243
Echinococcus granulosus lamin dm0 0.0029 0.0053 0.0173
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0048 0.0157
Schistosoma mansoni netrin receptor unc5 0.0015 0.0015 0.0068
Trypanosoma brucei kinesin, putative 0.0021 0.003 0.085
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0028 0.0339
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0082 0.0489
Toxoplasma gondii sugar transporter ST2 0.0052 0.0117 0.9287
Brugia malayi hypothetical protein 0.0035 0.0069 0.0409
Loa Loa (eye worm) hypothetical protein 0.0049 0.0107 0.0635
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0023 0.0035 0.0035
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0028 0.0339
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.0255 0.7335
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0126 0.362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0339
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0023 0.0035 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0185 0.5307
Echinococcus granulosus solute carrier family 22 0.0052 0.0117 0.0385
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0023 0.0035 0.0315
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0283
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0183 0.0809
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0025 0.0111
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0008 0.0036
Brugia malayi Cathepsin L-like precursor 0.002 0.0028 0.0169
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0028 0.0126
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0023 0.0035 0.0315
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0001 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0185 0.5307
Trypanosoma brucei sugar transporter, putative 0.0052 0.0117 0.3362
Trypanosoma brucei calpain-like protein, putative 0.0021 0.003 0.085
Echinococcus granulosus cysteine protease 0.001 0.0001 0.0005
Trypanosoma cruzi cysteine protease, putative 0.001 0.0001 0.0042
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0008 0.0048
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0018
Plasmodium vivax hexose transporter 0.0052 0.0117 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0023 0.0035 0.0035
Toxoplasma gondii sugar transporter ST1 0.0052 0.0117 0.9287
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0117 0.1396
Plasmodium vivax vivapain-1 0.001 0.0001 0.0126
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0126 0.1503
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0339
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0126 0.1503
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0043 0.0043
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0154 0.138
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.001 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0185 0.5307
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0061
Trypanosoma brucei glucose transporter, putative 0.0052 0.0117 0.3362
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0025 0.2161
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0076 0.0454
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0126 0.362
Plasmodium vivax calpain, putative 0.0021 0.003 0.2529
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.0255 0.3045
Brugia malayi calpain family protein 1 0.0069 0.0163 0.0972
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0339
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0339
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0194 0.0507 0.7521
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0255 0.1127
Onchocerca volvulus 0.0052 0.0117 0.1734
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0052 0.0117 0.0117
Loa Loa (eye worm) major facilitator superfamily transporter 0.0052 0.0117 0.0695
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0185 0.5307
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Chlamydia trachomatis recombinase RecA 0.0116 0.0292 0.2549
Brugia malayi Cathepsin L-like precursor 0.0014 0.001 0.006
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.0255 0.1517
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0315 0.0838 1
Brugia malayi Uncoordinated protein 44 0.0015 0.0015 0.0091
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0416 0.1116 0.3338
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0052 0.0117 0.0517
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0291 0.1732
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0025 0.2161
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0015 0.0051
Echinococcus multilocularis solute carrier family 22 0.0052 0.0117 0.0517
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0048
Entamoeba histolytica cysteine proteinase 1, putative 0.001 0.0001 0.0018
Trypanosoma cruzi hexose transporter, putative 0.0052 0.0117 0.3362
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0154 0.0681
Onchocerca volvulus 0.0049 0.0107 0.1583
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0255 0.3045
Echinococcus granulosus single minded 2 0.0039 0.0079 0.0261
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0061 0.027
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0016 0.007
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0028 0.0126
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0035 0.1012
Onchocerca volvulus 0.0071 0.0168 0.2492
Brugia malayi Major Facilitator Superfamily protein 0.0052 0.0117 0.0695
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0015 0.0091
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0048 0.0283
Trypanosoma brucei THT1 - hexose transporter, putative 0.0052 0.0117 0.3362
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0695
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0076 0.0911
Leishmania major cysteine peptidase A (CPA) 0.002 0.0028 0.0817
Echinococcus granulosus intermediate filament protein 0.0029 0.0053 0.0173
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0028 0.0126
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0023 0.0035 0.0315
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0114 0.136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0339
Onchocerca volvulus 0.002 0.0028 0.0421
Onchocerca volvulus Cathepsin L homolog 0.002 0.0028 0.0421
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.0402 0.1775
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0008 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0838 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0043 0.0385
Echinococcus granulosus solute carrier family 22 0.0052 0.0117 0.0385
Echinococcus granulosus death domain containing protein 0.0015 0.0015 0.0051
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0048 0.021
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0082 0.0271
Loa Loa (eye worm) cytochrome P450 0.0023 0.0035 0.0209
Loa Loa (eye worm) calpain family protein 1 0.0069 0.0163 0.0972
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0023 0.0035 0.0315
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0283
Giardia lamblia MRP-like ABC transporter 0.0015 0.0015 0.0178
Trichomonas vaginalis glucose transporter, putative 0.0052 0.0117 0.1396
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0023 0.0035 0.0315
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0838 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0068
Brugia malayi Death domain containing protein 0.0015 0.0015 0.0091
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0116 0.0292 0.1753
Plasmodium vivax vivapain-2 0.002 0.0028 0.243
Echinococcus multilocularis calpain 0.0021 0.003 0.0131
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0416 0.1116 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.001 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0048 0.0283
Onchocerca volvulus Cathepsin L homolog 0.002 0.0028 0.0421
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0048 0.0283
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0048 0.021
Trypanosoma cruzi hexose transporter, putative 0.0052 0.0117 0.3362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0339
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.015
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.003 0.085
Schistosoma mansoni hypothetical protein 0.0019 0.0025 0.0111
Brugia malayi conserved hypotetical protein 0.0013 0.0008 0.0048
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0015 0.0068
Schistosoma mansoni calpain-7 (C02 family) 0.0024 0.0038 0.017
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0048 0.0283
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0036 0.0071 0.2046
Echinococcus multilocularis solute carrier family 22 0.0052 0.0117 0.0517
Onchocerca volvulus 0.0052 0.0117 0.1734
Brugia malayi cytochrome P450 0.0023 0.0035 0.0209
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0073
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0126 0.362
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0838 1
Brugia malayi calpain 5 0.0021 0.003 0.0176
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0023 0.0035 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0185 0.5307
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0008 0.0036
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0315 0.0838 1
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0034 0.0065 0.1868
Echinococcus multilocularis mitogen activated protein kinase 11 0.0136 0.0348 0.1537
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0117 0.1396
Echinococcus multilocularis jun protein 0.009 0.0221 0.0978
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0136 0.0348 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0048 0.0283
Onchocerca volvulus 0.0052 0.0117 0.1734
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0099 0.1181
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0023 0.0035 0.0315
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0076 0.6526
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0035 0.1012
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0028 0.0126
Leishmania major cathepsin L-like protease 0.0077 0.0185 0.5307
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0695
Onchocerca volvulus 0.0052 0.0117 0.1734
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0136 0.0348 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.003 0.085
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0079 0.0711
Entamoeba histolytica ATP-binding cassette protein, putative 0.0015 0.0015 0.0178
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.001 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0339
Brugia malayi steroid hormone receptor 0.0027 0.0048 0.0283
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.003 0.085
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0297 0.0788 0.3483
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0076 0.0911
Onchocerca volvulus 0.0013 0.0008 0.012
Onchocerca volvulus 0.0029 0.0053 0.0781
Brugia malayi Sugar transporter family protein 0.0052 0.0117 0.0695
Entamoeba histolytica ATP-binding cassette protein, putative 0.0015 0.0015 0.0178
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2263 1
Entamoeba histolytica hypothetical protein 0.0035 0.0069 0.0821
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0018
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2263 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0043 0.0385
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0014 0.04
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0183 0.0809
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0001 0.0042
Brugia malayi Cathepsin L-like precursor 0.002 0.0028 0.0169
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0695
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0082 0.0982
Brugia malayi intermediate filament protein 0.0029 0.0053 0.0313
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0061 0.0201
Echinococcus granulosus GPCR family 2 0.0019 0.0025 0.0083
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0053 0.0313
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.001 0.0044
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0088 0.1056
Schistosoma mansoni lamin 0.0029 0.0053 0.0233
Leishmania major cathepsin L-like protease 0.002 0.0028 0.0817
Leishmania major glucose transporter/membrane transporter D2, putative 0.0052 0.0117 0.3362
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.0255 0.3784
Echinococcus multilocularis mitogen activated protein kinase 14 0.0136 0.0348 0.1537
Loa Loa (eye worm) major facilitator superfamily transporter 0.0052 0.0117 0.0695
Brugia malayi beta-NAC-like protein 0.0038 0.0076 0.0454
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0016 0.0093
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0416 0.1116 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0339
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0048 0.0283
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0069 0.0163 0.0722
Loa Loa (eye worm) cysteine protease 0.002 0.0028 0.0169
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0048 0.021
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0035 0.1012
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0297 0.0788 0.2596
Echinococcus granulosus Solute carrier family 22 5 0.1115 0.3036 1
Leishmania major glucose transporter, lmgt2 0.0052 0.0117 0.3362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0339
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0035 0.0209
Brugia malayi multidrug resistance related protein 1 0.0015 0.0015 0.0089
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0001 0.0007
Brugia malayi P38 map kinase family protein 2 0.0136 0.0348 0.2068
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0008 0.0027
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.0402 0.1775
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Trichomonas vaginalis set domain proteins, putative 0.0255 0.0674 0.8043
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0117 0.1396
Trichomonas vaginalis sugar transport protein, putative 0.0052 0.0117 0.1396
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0001 0.0018
Brugia malayi Major Facilitator Superfamily protein 0.0052 0.0117 0.0695
Schistosoma mansoni hypothetical protein 0.0019 0.0025 0.0111
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Onchocerca volvulus 0.0052 0.0117 0.1734
Brugia malayi Sugar transporter family protein 0.0052 0.0117 0.0695
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0255 0.3045
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0082 0.0982
Echinococcus multilocularis multidrug resistance associated protein 7 0.0015 0.0015 0.0066
Brugia malayi Cytochrome P450 family protein 0.0023 0.0035 0.0209
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0283
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.0255 0.1127
Schistosoma mansoni zinc finger protein 0.0013 0.0008 0.0036
Schistosoma mansoni transcription factor btf3 0.0038 0.0076 0.0337
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0043 0.0256
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0001 0.0042
Schistosoma mansoni intermediate filament proteins 0.0029 0.0053 0.0233
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0016 0.0093
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0048 0.021
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0048 0.0706
Echinococcus multilocularis lamin dm0 0.0029 0.0053 0.0233
Echinococcus granulosus mitogen activated protein kinase 14 0.0136 0.0348 0.1145
Trypanosoma cruzi multidrug resistance protein E, putative 0.0015 0.0015 0.0428
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0138 0.0822
Brugia malayi Cathepsin L-like precursor 0.002 0.0028 0.0169
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0001 0.0009
Echinococcus granulosus calpain 0.0021 0.003 0.0097
Echinococcus granulosus calpain A 0.0021 0.003 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0048 0.0283
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0043 0.0385
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0028 0.243
Trypanosoma cruzi hypothetical protein 0.0012 0.0005 0.0148
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0183 0.1088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0048 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0076 0.0911
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0023 0.0035 0.0315
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0073 0.0173 0.0765
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0048 0.0283
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.001 0.0295
Echinococcus granulosus Ankyrin 0.0016 0.0016 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Loa Loa (eye worm) hypothetical protein 0.0088 0.0215 0.1275
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0018
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0028 0.0094
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.006
Leishmania major cathepsin L-like protease 0.002 0.0028 0.0817
Toxoplasma gondii cytochrome p450 superfamily protein 0.0023 0.0035 0.2796
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0185 0.5307
Loa Loa (eye worm) hypothetical protein 0.0053 0.0118 0.0699
Echinococcus granulosus calpain 7 C02 family 0.0021 0.003 0.0097
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0136 0.0348 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0154 0.0395 0.3541
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0114 0.136
Onchocerca volvulus 0.002 0.0028 0.0421
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0001 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0048 0.0283
Leishmania major cathepsin L-like protease 0.002 0.0028 0.0817
Schistosoma mansoni hypothetical protein 0.0023 0.0035 0.0156
Mycobacterium leprae Conserved hypothetical protein 0.0023 0.0035 0.0105
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0126 0.362
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0059
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0695
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0048 0.021
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0008 0.0036
Echinococcus granulosus hypothetical protein 0.075 0.2033 0.6697
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.003 0.085
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0052 0.0117 0.0517
Onchocerca volvulus 0.002 0.0028 0.0421
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0082 0.0364
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0015 0.0015 0.0428
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0048 0.021
Toxoplasma gondii sugar transporter ST3 0.0052 0.0117 0.9287
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0048 0.021
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0255 0.3045
Trypanosoma brucei glucose transporter, putative 0.0052 0.0117 0.3362
Echinococcus granulosus synaptic vesicle 2 protein 0.0053 0.0118 0.0387
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0059
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0015 0.0015 0.0089
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0008 0.0048
Trypanosoma brucei calpain-like protein, putative 0.0021 0.003 0.085
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.003 0.0131
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0001 0.0018
Echinococcus granulosus cytochrome P450 2K1 0.0023 0.0035 0.0116
Trichomonas vaginalis glucose transporter, putative 0.0052 0.0117 0.1396
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0048 0.0283
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0015 0.0015 0.0428
Loa Loa (eye worm) twinkle helicase 0.0119 0.03 0.1781
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0082 0.0364
Echinococcus multilocularis calpain family protein 1, d 0.0049 0.0107 0.0472
Loa Loa (eye worm) hypothetical protein 0.0049 0.0107 0.0635
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0048 0.021
Echinococcus multilocularis geminin 0.0347 0.0926 0.4093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0061 0.027
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0014 0.04
Giardia lamblia Multidrug resistance-associated protein 1 0.0015 0.0015 0.0178
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.003 0.085
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0695
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0008 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0023 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0048
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0126 0.0556
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0126 0.1503
Trypanosoma brucei calpain-like protein, putative 0.0021 0.003 0.085
Echinococcus multilocularis abhydrolase domain containing protein 0.0041 0.0085 0.0375
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0048
Brugia malayi hydrolase, alpha/beta fold family protein 0.0041 0.0085 0.0505
Loa Loa (eye worm) calpain 0.0021 0.003 0.0176
Trypanosoma brucei calpain-like protein, putative 0.0021 0.003 0.085
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0025 0.015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0048 0.021
Entamoeba histolytica hypothetical protein 0.0035 0.0069 0.0821
Trypanosoma brucei glucose transporter, putative 0.0052 0.0117 0.3362
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0048 0.0283
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0126 1
Echinococcus granulosus jun protein 0.009 0.0221 0.0729
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0126 0.0556
Trypanosoma cruzi DNA repair protein, putative 0.0036 0.0071 0.2046
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0018
Treponema pallidum fructose-bisphosphate aldolase 0.0315 0.0838 0.6619
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0126 0.362
Onchocerca volvulus 0.0052 0.0117 0.1734
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0001 0.0018
Leishmania major pentamidine resistance protein 1 0.0015 0.0015 0.0428
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0053 0.0313
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.0255 0.1517
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0339
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0117 0.0516
Schistosoma mansoni sugar transporter 0.0052 0.0117 0.0517
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0695
Trypanosoma cruzi sugar transporter, putative 0.0052 0.0117 0.3362
Schistosoma mansoni calpain (C02 family) 0.0021 0.003 0.0131
Brugia malayi Cytochrome P450 family protein 0.0023 0.0035 0.0209
Schistosoma mansoni single-minded 0.0052 0.0117 0.0516
Loa Loa (eye worm) cytochrome P450 family protein 0.0124 0.0315 0.1872
Echinococcus granulosus lamin 0.0029 0.0053 0.0173
Echinococcus multilocularis calpain A 0.0073 0.0173 0.0765
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0048 0.0283
Echinococcus multilocularis lamin 0.0029 0.0053 0.0233
Plasmodium vivax sugar transporter, putative 0.0052 0.0117 1
Schistosoma mansoni lamin 0.0029 0.0053 0.0233
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0015 0.0228
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0012 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.001 0.0122
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0028 0.0169
Onchocerca volvulus 0.002 0.0028 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0082 0.0982
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0023 0.0035 0.1012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0339
Brugia malayi nuclear receptor RXR 0.0013 0.0008 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0012 0.0073
Brugia malayi MAP kinase sur-1 0.0056 0.0126 0.0749
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0048 0.021
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0015 0.0015 0.0428
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0048 0.0157
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0018
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0048 0.021
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0013 0.0008 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.001 0.0122
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0073 0.0173 0.0765
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Echinococcus multilocularis multidrug resistance associated protein 4 0.0012 0.0005 0.0023
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.003 0.085
Schistosoma mansoni multidrug resistance protein 0.0015 0.0015 0.0066
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Entamoeba histolytica hypothetical protein 0.0035 0.0069 0.0821
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0695
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0023 0.0035 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0255 0.3045
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0048 0.021
Leishmania major p-glycoprotein e 0.0015 0.0015 0.0428
Loa Loa (eye worm) hypothetical protein 0.0194 0.0507 0.3014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0185 0.5307
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0012 0.0073
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Brugia malayi Cathepsin L-like precursor 0.0014 0.001 0.006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0025 0.015
Schistosoma mansoni multidrug resistance protein 0.0015 0.0015 0.0066
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0052 0.0117 1
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0023 0.0035 0.0315
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0023 0.0035 0.0315
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0052 0.0117 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0048 0.0283
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0048 0.021
Leishmania major cytochrome p450-like protein 0.0023 0.0035 0.1012
Trypanosoma brucei THT1 - hexose transporter, putative 0.0052 0.0117 0.3362
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0023 0.0035 0.1012
Entamoeba histolytica protein kinase, putative 0.0022 0.0033 0.0396
Echinococcus granulosus cathepsin l1 0.002 0.0028 0.0094
Schistosoma mansoni hypothetical protein 0.0073 0.0175 0.0772
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0048 0.0283
Trypanosoma brucei glucose transporter, putative 0.0052 0.0117 0.3362
Schistosoma mansoni glucose transport protein 0.0052 0.0117 0.0517
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0048 0.021
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0183 0.1088
Echinococcus granulosus solute carrier family 22 0.0052 0.0117 0.0385
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.0191 0.0843
Echinococcus multilocularis cysteine protease 0.002 0.0028 0.0126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0001 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0023 0.0035 0.0035
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0043 0.1237
Trypanosoma cruzi hexose transporter 0.0052 0.0117 0.3362
Brugia malayi nuclear receptor RXR 0.0014 0.0012 0.0073
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0082 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0339
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0023 0.0035 0.0315
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0082 0.2366
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.001 0.006
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0053 0.0118 0.1053
Brugia malayi RNA binding protein 0.0076 0.0183 0.1088
Echinococcus granulosus tar DNA binding protein 0.0076 0.0183 0.0603
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0283
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0008 0.0048
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0154 0.138
Brugia malayi major facilitator superfamily protein 0.0052 0.0117 0.0695
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0023 0.0035 0.0035
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.001 0.0061
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.0402 0.2388
Onchocerca volvulus 0.0014 0.001 0.0149
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.003 0.0131
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0838 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0022 0.0022
Trypanosoma brucei multidrug resistance protein E 0.0015 0.0015 0.0428
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0069 0.0304
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.0154 0.4429
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0048 0.0706
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0126 0.362
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0023 0.0035 0.0035
Schistosoma mansoni cytochrome P450 0.0023 0.0035 0.0156
Echinococcus granulosus cathepsin L 0.001 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0695
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0339
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0076 0.6061
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0183 0.0809
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.003 0.085
Onchocerca volvulus 0.0016 0.0016 0.0242
Echinococcus multilocularis hypothetical protein 0.0021 0.003 0.0131
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0082 0.0364
Loa Loa (eye worm) multidrug resistance-associated protein 0.0012 0.0005 0.0033
Echinococcus granulosus multidrug resistance associated protein 7 0.0015 0.0015 0.0049
Echinococcus granulosus cathepsin l1 0.0014 0.001 0.0033
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0052 0.0117 0.0117
Brugia malayi bZIP transcription factor family protein 0.009 0.0221 0.1316
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.009 0.0221 0.0729
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0076 0.2194
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.001 0.0122
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0023 0.0035 0.0315
Toxoplasma gondii cathepsin CPL 0.002 0.0028 0.2257
Brugia malayi hypothetical protein 0.0014 0.0012 0.0073
Onchocerca volvulus 0.0052 0.0117 0.1734
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.003 0.085
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0023 0.0035 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0028 0.0339
Echinococcus granulosus abhydrolase domain containing protein 0.0041 0.0085 0.0279
Schistosoma mansoni hydrolase 0.0041 0.0085 0.0375
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0023 0.0035 0.0315
Loa Loa (eye worm) hydrolase 0.0041 0.0085 0.0505
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0025 0.0136
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0015 0.0015 0.0428
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0023 0.0035 0.0035
Brugia malayi hypothetical protein 0.0013 0.0008 0.0048
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0023 0.0035 0.0035
Schistosoma mansoni glucose transporter 0.0052 0.0117 0.0517
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0076 0.2194
Leishmania major hypothetical protein, conserved 0.0052 0.0117 0.3362
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0695
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0008 0.0048
Echinococcus granulosus solute carrier family 22 0.0052 0.0117 0.0385
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0082 0.0271
Leishmania major cathepsin L-like protease 0.0077 0.0185 0.5307
Mycobacterium ulcerans integral membrane transport protein 0.0052 0.0117 0.1047
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0126 0.0556
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0043 0.0513
Loa Loa (eye worm) sugar transporter 0.0052 0.0117 0.0695
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0023 0.0035 0.0035
Onchocerca volvulus 0.0026 0.0043 0.0638
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0018
Echinococcus multilocularis synaptic vesicle 2 protein 0.0053 0.0118 0.0519
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0028 0.0339
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0138 0.0822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0339
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0138 0.0822
Leishmania major cathepsin L-like protease 0.002 0.0028 0.0817
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0304
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0838 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.001 0.0122
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0076 0.2194
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0053 0.0313
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0082 0.0364
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0069 0.0227
Echinococcus multilocularis solute carrier family 22 0.0052 0.0117 0.0517
Trypanosoma brucei THT1 - hexose transporter, putative 0.0052 0.0117 0.3362
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0023 0.0035 0.0035
Echinococcus granulosus transcription factor btf3 0.0038 0.0076 0.0251
Schistosoma mansoni kinase 0.0053 0.0118 0.052
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.001 0.0045
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0364
Echinococcus multilocularis cysteine protease 0.002 0.0028 0.0126
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0076 0.0911
Schistosoma mansoni hypothetical protein 0.0052 0.0117 0.0517
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0052 0.0117 0.3362
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0695
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0139 0.4004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0008 0.0027
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0079 0.0351
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0052 0.0117 0.0385
Trichomonas vaginalis myo-inositol transporter, putative 0.0052 0.0117 0.1396
Mycobacterium ulcerans hypothetical protein 0.0026 0.0043 0.0385
Echinococcus granulosus calpain 5 0.0021 0.003 0.0097
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0008 0.0027
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0015 0.0068
Onchocerca volvulus 0.0052 0.0117 0.1734
Brugia malayi nuclear hormone receptor 0.0013 0.0008 0.0048
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0008 0.0048
Entamoeba histolytica hypothetical protein 0.0015 0.0015 0.0178
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0015 0.0015 0.0428
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0048 0.021
Loa Loa (eye worm) fibroinase 0.002 0.0028 0.0169
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0154 0.0395 0.0395
Onchocerca volvulus 0.0032 0.0061 0.0908
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0695
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0043 0.0129
Schistosoma mansoni sugar transporter 0.0052 0.0117 0.0517
Echinococcus multilocularis multidrug resistance associated protein 1 0.0015 0.0015 0.0066
Schistosoma mansoni glucose transport protein 0.0052 0.0117 0.0517
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Brugia malayi ABC transporter transmembrane region family protein 0.0015 0.0015 0.0089
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Echinococcus multilocularis musashi 0.0029 0.0053 0.0233
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.0255 0.084
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0048
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0082 0.0364
Schistosoma mansoni hypothetical protein 0.0041 0.0086 0.038
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0028 0.0169
Brugia malayi Sugar transporter family protein 0.0052 0.0117 0.0695
Leishmania major cathepsin L-like protease 0.0077 0.0185 0.5307
Echinococcus granulosus multidrug resistance associated protein 4 0.0012 0.0005 0.0017
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0255 0.0672 0.3997
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0043 0.0385
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.009 0.0221 0.0978
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.015
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0183 0.0809
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0154 0.0395 0.1182
Brugia malayi follicle stimulating hormone receptor 0.0255 0.0672 0.3997
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0082 0.2366
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0183 0.1088
Onchocerca volvulus 0.002 0.0028 0.0421
Echinococcus multilocularis 0.0023 0.0035 0.0156
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Onchocerca volvulus 0.0013 0.0008 0.012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0313
Loa Loa (eye worm) calpain 5 0.0021 0.003 0.0176
Mycobacterium ulcerans recombinase A 0.0116 0.0292 0.2617
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.003 0.085
Schistosoma mansoni hypothetical protein 0.0035 0.0069 0.0304
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0015 0.0015 0.0428
Trypanosoma brucei p-glycoprotein 0.0015 0.0015 0.0428
Brugia malayi calpain family protein 1 0.0069 0.0163 0.0972
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0023 0.0035 0.0035
Brugia malayi Cathepsin L-like precursor 0.002 0.0028 0.0169
Echinococcus granulosus Sugar transporter ERD6 protein 0.0052 0.0117 0.0385
Schistosoma mansoni nuclear receptor nhr-48 0.0013 0.0008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0048
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0035 0.0315
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0073
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.001 0.0122
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Trypanosoma cruzi glucose transporter, putative 0.0052 0.0117 0.3362
Brugia malayi Cytochrome P450 family protein 0.0124 0.0315 0.1872
Onchocerca volvulus 0.0052 0.0117 0.1734
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.003 0.085
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0082 0.2366
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0061 0.027
Leishmania major kinesin, putative 0.0021 0.003 0.085
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0008 0.0027
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.039 0.1283
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0025 0.0083
Loa Loa (eye worm) hypothetical protein 0.0069 0.0163 0.0972
Giardia lamblia Sugar-proton symporter 0.0052 0.0117 0.1396
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013 0.0008 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0048 0.0283
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0011 0.005
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0073 0.0173 0.0765
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0061 0.027
Loa Loa (eye worm) hypothetical protein 0.0176 0.0456 0.271
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0001 0.0018
Entamoeba histolytica hypothetical protein 0.0035 0.0069 0.0821
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0256
Schistosoma mansoni jun-related protein 0.0073 0.0175 0.0772
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.001 0.012
Giardia lamblia Multidrug resistance-associated protein 1 0.0015 0.0015 0.0174
Onchocerca volvulus 0.0034 0.0065 0.0963
Echinococcus multilocularis mitogen activated protein kinase 11 0.0136 0.0348 0.1537
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0028 0.0126
Onchocerca volvulus 0.002 0.0028 0.0421
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0838 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0048
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Schistosoma mansoni sugar transporter 0.0052 0.0117 0.0517
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0015 0.0015 0.1183
Brugia malayi Cathepsin L-like precursor 0.002 0.0028 0.0169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0001 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0048 0.0283
Onchocerca volvulus Cathepsin F homolog 0.002 0.0028 0.0421
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.0154 0.0681
Trypanosoma brucei glucose transporter, putative 0.0052 0.0117 0.3362
Echinococcus multilocularis cathepsin L 0.001 0.0001 0.0007
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.0255 0.7335
Entamoeba histolytica multidrug resistance protein, putative 0.0015 0.0015 0.0178
Brugia malayi Cathepsin L-like precursor 0.002 0.0028 0.0169
Schistosoma mansoni nuclear receptor 0.0013 0.0008 0.0036
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0023 0.0035 0.0315
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0023 0.0035 0.1012
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0028 0.0817
Onchocerca volvulus 0.0027 0.0048 0.0706
Trichomonas vaginalis sugar transporter, putative 0.0052 0.0117 0.1396
Brugia malayi Protein kinase domain containing protein 0.0017 0.0019 0.0113
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0001 0.0007
Brugia malayi Pre-SET motif family protein 0.0224 0.0589 0.35
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0016 0.0016 0.0016
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0052 0.0117 0.0517
Leishmania major hypothetical protein, conserved 0.0041 0.0085 0.244
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0117 0.1396
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0023 0.0035 0.0315
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0052 0.0117 0.0385
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0052 0.0117 0.0517
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0154 0.0916
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0339
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0126 0.1503
Echinococcus granulosus calpain A 0.0073 0.0173 0.057
Schistosoma mansoni multidrug resistance protein 0.0015 0.0015 0.0066
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0015 0.0051
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0035 0.1012
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0061 0.027
Leishmania major glucose transporter, lmgt1 0.0052 0.0117 0.3362
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0008 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0185 0.5307
Leishmania major glucose transporter, lmgt3 0.0052 0.0117 0.3362
Mycobacterium leprae putative cytochrome p450 0.0023 0.0035 0.0105
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0048 0.0157
Entamoeba histolytica ATP-binding cassette protein, putative 0.0015 0.0015 0.0178
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0043 0.0385
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0023 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0048
Echinococcus granulosus geminin 0.0347 0.0926 0.305
Trypanosoma cruzi kinesin, putative 0.0021 0.003 0.085
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0018
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.001 0.0122
Trypanosoma brucei glucose transporter, putative 0.0052 0.0117 0.3362
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0339
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0023 0.0035 0.0315
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.015
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0154 0.0154
Trichomonas vaginalis glucose transporter, putative 0.0052 0.0117 0.1396
Onchocerca volvulus 0.0014 0.001 0.0152
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.001 0.0295
Brugia malayi Pre-SET motif family protein 0.0032 0.0061 0.0364
Brugia malayi hypothetical protein 0.0013 0.0008 0.0048
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0008 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0043 0.0256
Entamoeba histolytica hypothetical protein 0.0038 0.0076 0.0911
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0048 0.021
Onchocerca volvulus 0.0052 0.0117 0.1734
Leishmania major cathepsin L-like protease 0.002 0.0028 0.0817
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0117 0.1396
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0099 0.7861
Brugia malayi hypothetical protein 0.0052 0.0117 0.0695
Schistosoma mansoni nuclear receptor 0.0013 0.0008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.015
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0043 0.0385
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0018
Leishmania major cytochrome p450-like protein 0.0023 0.0035 0.1012
Plasmodium vivax vivapain-2 0.002 0.0028 0.243
Loa Loa (eye worm) hypothetical protein 0.0622 0.1682 1
Echinococcus multilocularis solute carrier family 22 0.0052 0.0117 0.0517
Loa Loa (eye worm) RNA binding protein 0.0076 0.0183 0.1088
Loa Loa (eye worm) hypothetical protein 0.0052 0.0117 0.0695
Trypanosoma cruzi DNA repair protein, putative 0.0036 0.0071 0.2046
Leishmania major protein kinase, putative 0.0015 0.0014 0.04
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0091
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0082 0.0982
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0283

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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