Detailed information for compound 20244

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 331.452 | Formula: C19H29N3O2
  • H donors: 2 H acceptors: 1 LogP: 3.58 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1c(OC)cc(c2c1c(C)ccn2)NC(CCCN)C
  • InChi: 1S/C19H29N3O2/c1-5-11-24-19-16(23-4)12-15(22-14(3)7-6-9-20)18-17(19)13(2)8-10-21-18/h8,10,12,14,22H,5-7,9,11,20H2,1-4H3
  • InChiKey: BSGAORSFFAGDFR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0019 0.0027
Echinococcus multilocularis musashi 0.008 0.0202 0.02
Schistosoma mansoni multidrug resistance protein 0.0021 0.0019 0.0028
Echinococcus granulosus tubulin alpha chain 0.1139 0.352 0.5525
Entamoeba histolytica hypothetical protein 0.0142 0.0398 0.0796
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0026 0.005
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0054 0.0107
Loa Loa (eye worm) tubulin alpha-2 chain 0.1139 0.352 0.7128
Loa Loa (eye worm) hypothetical protein 0.0061 0.0143 0.0287
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0013 0.0027
Schistosoma mansoni cytochrome P450 0.0018 0.0008 0.0011
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0305 0.0615
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0047 0.0094
Loa Loa (eye worm) CBP-B 0.014 0.039 0.0788
Schistosoma mansoni loxhd1 0.0157 0.0444 0.0695
Mycobacterium leprae conserved hypothetical protein 0.002 0.0014 0.0052
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0271 0.0539
Loa Loa (eye worm) hypothetical protein 0.0646 0.1975 0.3997
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0109 0.021
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0025 0.0031 0.003
Brugia malayi bHLH-PAS transcription factor 0.0142 0.0399 0.0807
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0027 0.0055
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0213 0.0621 0.5345
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0008 0.0014
Brugia malayi tubulin alpha chain - mouse 0.1139 0.352 0.7129
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0288 0.0582
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0288 0.0573
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0288 0.0573
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.006
Brugia malayi hypothetical protein 0.0157 0.0444 0.0899
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0074 0.0186 0.1552
Schistosoma mansoni tubulin subunit alpha 0.1139 0.352 0.5525
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0019 0.0027
Onchocerca volvulus 0.0157 0.0444 0.3026
Trypanosoma cruzi PAB1-binding protein , putative 0.01 0.0265 0.0534
Echinococcus multilocularis tubulin subunit beta 0.1592 0.4938 0.4938
Echinococcus multilocularis Tubulin alpha 1 chain 0.1139 0.352 0.352
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.0686 0.0685
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0047 0.0083
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.009 0.0233 0.0461
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0384 0.1155 1
Echinococcus multilocularis bloom syndrome protein 0.004 0.0079 0.0078
Echinococcus multilocularis tubulin beta 1 chain 0.1592 0.4938 0.4938
Leishmania major protein kinase, putative 0.0051 0.0112 0.0225
Loa Loa (eye worm) hypothetical protein 0.0074 0.0186 0.0374
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0085 0.0132
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0058 0.0135 0.0849
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.0006 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0161 0.0315
Plasmodium vivax delta tubulin, putative 0.0384 0.1155 0.2336
Leishmania major beta tubulin 0.1592 0.4938 1
Echinococcus granulosus agrin 0.0057 0.0131 0.0204
Plasmodium falciparum thioredoxin reductase 0.0032 0.0054 0.0107
Echinococcus multilocularis ecdysone induced protein 78C 0.0058 0.0135 0.0133
Loa Loa (eye worm) hypothetical protein 0.0057 0.0131 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0104 0.0199
Loa Loa (eye worm) hypothetical protein 0.0033 0.0056 0.0112
Brugia malayi Tubulin gamma chain 0.0878 0.2704 0.5476
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0166 0.0473 0.074
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.005 0.0109 0.0219
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0057 0.0131 0.0264
Echinococcus multilocularis Tubulin beta 2C chain 0.1592 0.4938 0.4938
Loa Loa (eye worm) hypothetical protein 0.01 0.0265 0.0534
Echinococcus multilocularis beta tubulin 0.1592 0.4938 0.4938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0176 0.0345
Trichomonas vaginalis tubulin beta chain, putative 0.1139 0.352 0.7126
Schistosoma mansoni organic anion transporter 0.0084 0.0214 0.0335
Echinococcus granulosus raf serine:threonine protein kinase 0.0043 0.0086 0.0133
Onchocerca volvulus 0.0142 0.0399 0.2706
Plasmodium falciparum tubulin gamma chain 0.0878 0.2704 0.5475
Echinococcus granulosus tubulin alpha 3 chain 0.1139 0.352 0.5525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0161 0.0315
Brugia malayi hypothetical protein 0.013 0.0361 0.0731
Leishmania major beta tubulin 0.1592 0.4938 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0467 0.1417 0.2861
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0288 0.2447
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0085 0.0162
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0053 0.0082
Onchocerca volvulus 0.0084 0.0214 0.1411
Brugia malayi Doublecortin family protein 0.0157 0.0444 0.0899
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0019 0.0018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0145 0.0226
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0237 0.0695 0.5996
Schistosoma mansoni nuclear receptor 0.0025 0.0031 0.0046
Giardia lamblia Gamma tubulin 0.0878 0.2704 0.5467
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0755 0.2318 0.4693
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0067 0.0066
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0031 0.0046
Trypanosoma cruzi tubulin delta chain 0.0552 0.1681 0.3402
Toxoplasma gondii transporter, major facilitator family protein 0.0084 0.0214 0.0432
Entamoeba histolytica P-glyco protein 6, putative 0.0021 0.0019 0.0027
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0067 0.0125
Loa Loa (eye worm) tubulin alpha-3 chain 0.0672 0.2056 0.4162
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0067 0.0125
Onchocerca volvulus Protein ultraspiracle homolog 0.0058 0.0135 0.0849
Leishmania major zeta tubulin, putative 0.0665 0.2034 0.4118
Onchocerca volvulus 0.0197 0.057 0.3914
Giardia lamblia Kinase, CMGC MAPK 0.0102 0.0271 0.0531
Brugia malayi Raf kinase 0.0043 0.0086 0.0174
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0219
Loa Loa (eye worm) intermediate filament protein 0.008 0.0202 0.0406
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.0186 0.0374
Leishmania major beta tubulin 0.1592 0.4938 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0054 0.0109
Brugia malayi ecdysteroid receptor 0.0058 0.0135 0.0272
Loa Loa (eye worm) hypothetical protein 0.0157 0.0444 0.0897
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0042 0.0085 0.0132
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0031 0.0046
Brugia malayi jmjC domain containing protein 0.0058 0.0135 0.0273
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0047 0.0071
Leishmania major alpha tubulin 0.1139 0.352 0.7128
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0049 0.0096
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.009 0.0233 0.047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.0135 0.0209
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.005 0.0098
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0067 0.0104
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.005 0.0076
Schistosoma mansoni tubulin subunit alpha 0.1139 0.352 0.5525
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.001 0.0009
Echinococcus granulosus cpg binding protein 0.006 0.0139 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0109 0.021
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0019 0.0027
Schistosoma mansoni lipoxygenase 0.0344 0.1029 0.1613
Brugia malayi MH2 domain containing protein 0.0032 0.0053 0.0108
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0071 0.0142
Echinococcus multilocularis transfer RNA-Lys 0.0142 0.0399 0.0397
Trichomonas vaginalis tubulin alpha chain, putative 0.1592 0.4938 1
Echinococcus granulosus lamin dm0 0.008 0.0202 0.0315
Echinococcus granulosus sterol regulatory element binding protein 0.0083 0.0212 0.0331
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0067 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0161 0.0315
Echinococcus granulosus neuropeptide receptor A26 0.0909 0.28 0.4395
Echinococcus multilocularis expressed conserved protein 0.0182 0.0521 0.052
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.005 0.0109 0.021
Brugia malayi Pre-SET motif family protein 0.0416 0.1256 0.2543
Giardia lamblia Beta tubulin 0.1592 0.4938 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0131 0.0264
Trypanosoma brucei tubulin delta chain 0.0552 0.1681 0.3402
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0132 0.0205
Echinococcus granulosus CREB binding protein 0.0033 0.0056 0.0086
Schistosoma mansoni hypothetical protein 0.0803 0.2467 0.3872
Leishmania major alpha tubulin 0.1139 0.352 0.7128
Trichomonas vaginalis abcb9, putative 0.0021 0.0019 0.0027
Schistosoma mansoni nuclear hormone receptor 0.0058 0.0135 0.0209
Entamoeba histolytica tubulin alpha-1 chain 0.1139 0.352 0.7126
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.005 0.0109 0.0219
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0288 0.0582
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0054 0.0098
Echinococcus granulosus FTZ F1 alpha 0.0058 0.0135 0.0209
Leishmania major beta tubulin 0.1592 0.4938 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0019 0.0018
Brugia malayi Isocitrate dehydrogenase 0.0031 0.005 0.01
Echinococcus granulosus Polycystic kidney disease protein 0.0157 0.0444 0.0695
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0002
Plasmodium vivax tubulin beta chain, putative 0.1592 0.4938 1
Schistosoma mansoni agrin 0.0057 0.0131 0.0204
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0054 0.0107
Toxoplasma gondii beta-1 tubulin, putative 0.1592 0.4938 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0054 0.0403
Plasmodium falciparum alpha tubulin 1 0.1139 0.352 0.7128
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0002
Brugia malayi nuclear receptor NHR-67 0.0025 0.0031 0.0062
Echinococcus multilocularis CREB binding protein 0.0033 0.0056 0.0055
Plasmodium falciparum tubulin beta chain 0.1592 0.4938 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0102 0.0271 0.027
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.009 0.0233 0.047
Echinococcus multilocularis axis inhibition protein axin 0.0042 0.0085 0.0084
Schistosoma mansoni steroid hormone receptor ad4bp 0.0058 0.0135 0.0209
Echinococcus multilocularis tubulin epsilon chain 0.0878 0.2703 0.2702
Schistosoma mansoni multidrug resistance protein 0.0021 0.0019 0.0028
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0384 0.1155 0.233
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0008 0.0014
Mycobacterium ulcerans hypothetical protein 0.002 0.0014 0.0052
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0085 0.0132
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0067 0.0136
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0057 0.0131 0.0264
Trypanosoma brucei beta tubulin 0.1592 0.4938 1
Echinococcus multilocularis tumor protein p63 0.1348 0.4174 0.4173
Brugia malayi Cytochrome P450 family protein 0.0053 0.0117 0.0238
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0045 0.0093 0.0091
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0014 0.0013
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0053 0.0052
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0102 0.0271 0.0547
Echinococcus multilocularis Polycystic kidney disease protein 0.0157 0.0444 0.0443
Echinococcus multilocularis tubulin alpha chain 0.1139 0.352 0.352
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0043 0.0076
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0067 0.0134
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0102 0.0271 0.0547
Trypanosoma brucei beta tubulin 0.1592 0.4938 1
Onchocerca volvulus Bile acid receptor homolog 0.0058 0.0135 0.0849
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0042 0.0085 0.0132
Trypanosoma brucei beta tubulin 0.1592 0.4938 1
Echinococcus granulosus axis inhibition protein axin 0.0042 0.0085 0.0132
Plasmodium vivax tubulin gamma chain, putative 0.0878 0.2704 0.5475
Brugia malayi hypothetical protein 0.0234 0.0686 0.139
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0049 0.0087
Loa Loa (eye worm) hypothetical protein 0.0102 0.0271 0.0546
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0058 0.0135 0.0133
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.006
Schistosoma mansoni hypothetical protein 0.0048 0.0102 0.0159
Leishmania major alpha tubulin 0.1139 0.352 0.7128
Schistosoma mansoni smad1 5 8 and 0.0032 0.0053 0.0082
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0043 0.0088 0.0177
Echinococcus multilocularis Tubulin beta 2C chain 0.1592 0.4938 0.4938
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0019 0.0027
Leishmania major gamma-tubulin 0.0878 0.2704 0.5475
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0047 0.0071
Schistosoma mansoni microtubule-associated protein tau 0.2049 0.637 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.001 0.0008
Schistosoma mansoni hypothetical protein 0.0045 0.0093 0.0144
Loa Loa (eye worm) cytochrome P450 0.0018 0.0008 0.0014
Brugia malayi MH1 domain containing protein 0.0032 0.0053 0.0108
Entamoeba histolytica hypothetical protein 0.0142 0.0398 0.0796
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0043 0.0085
Echinococcus granulosus lipoxygenase domain containing protein 0.0157 0.0444 0.0695
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.006
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0019 0.0018
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0129 0.0259
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0058 0.0135 0.0209
Schistosoma mansoni polycystin 1-related 0.0157 0.0444 0.0695
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0054 0.0107
Toxoplasma gondii alpha-tubulin I, putative 0.1139 0.352 0.7128
Echinococcus granulosus expressed conserved protein 0.0182 0.0521 0.0816
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0047 0.0092
Echinococcus granulosus geminin 0.067 0.2052 0.322
Brugia malayi follicle stimulating hormone receptor 0.0238 0.0697 0.1412
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0019 0.0028
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0041 0.004
Echinococcus multilocularis Tubulin alpha 1 chain 0.1139 0.352 0.352
Leishmania major beta tubulin 0.1592 0.4938 1
Echinococcus multilocularis 0.0018 0.0008 0.0007
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0019 0.0027
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0288 0.0582
Toxoplasma gondii beta-tubulin, putative 0.1592 0.4938 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0058 0.0135 0.0272
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0271 0.0539
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0019 0.0028
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0166 0.0473 0.0472
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0054 0.0107
Brugia malayi MH1 domain containing protein 0.0018 0.0008 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0067 0.0125
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0067 0.0117
Mycobacterium tuberculosis Probable oxidoreductase 0.0237 0.0695 0.5996
Loa Loa (eye worm) hypothetical protein 0.0057 0.0131 0.0264
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0626 0.1914 0.3003
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0018 0.0017
Trypanosoma brucei beta tubulin 0.0851 0.2619 0.5302
Echinococcus granulosus lipoxygenase domain containing protein 0.0157 0.0444 0.0695
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0053 0.0082
Loa Loa (eye worm) tubulin alpha 2 0.0288 0.0854 0.1727
Schistosoma mansoni lamin 0.008 0.0202 0.0315
Echinococcus granulosus tubulin alpha 3 chain 0.1139 0.352 0.5525
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0043 0.0085
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.005 0.0098
Schistosoma mansoni alpha tubulin 0.1139 0.352 0.5525
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0137 0.0214
Echinococcus multilocularis hypothetical protein 0.1139 0.352 0.352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0161 0.0315
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0019 0.0027
Plasmodium falciparum thioredoxin reductase 0.0094 0.0245 0.0495
Schistosoma mansoni ap endonuclease 0.0018 0.001 0.0013
Brugia malayi isocitrate dehydrogenase 0.0031 0.005 0.01
Entamoeba histolytica P-glycoprotein 5, putative 0.0021 0.0019 0.0027
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0288 0.2447
Echinococcus granulosus CREB binding protein 0.0033 0.0056 0.0086
Schistosoma mansoni RAR-like nuclear receptor 0.0058 0.0135 0.0209
Plasmodium vivax multidrug resistance protein 1, putative 0.0021 0.0019 0.0036
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0043 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0233 0.0461
Brugia malayi Pre-SET motif family protein 0.0061 0.0143 0.0289
Echinococcus granulosus intermediate filament protein 0.008 0.0202 0.0315
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0043 0.0076
Schistosoma mansoni axis inhibition protein axin 0.0042 0.0085 0.0132
Plasmodium falciparum glutathione reductase 0.0094 0.0245 0.0495
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0057 0.0131 0.0264
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0038 0.0073 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0088 0.0137
Schistosoma mansoni tubulin subunit beta 0.1592 0.4938 0.7752
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0137 0.1129
Echinococcus multilocularis Regulator of G protein signaling 20 0.0042 0.0085 0.0084
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0021 0.0019 0.0097
Brugia malayi hypothetical protein 0.0242 0.0711 0.144
Toxoplasma gondii tubulin, putative 0.0027 0.0036 0.0071
Brugia malayi Cytochrome P450 family protein 0.0018 0.0008 0.0016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.005 0.0048
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0042 0.0085 0.017
Onchocerca volvulus 0.0061 0.0143 0.0906
Brugia malayi Cell division protein ftsZ 0.0384 0.1155 0.2338
Trichomonas vaginalis set domain proteins, putative 0.0473 0.1435 0.2898
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0031 0.003
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0047 0.0045
Echinococcus multilocularis protein patched 0.0083 0.0212 0.0211
Onchocerca volvulus 0.0021 0.0019 0.0036
Echinococcus granulosus Niemann Pick C1 protein 0.0276 0.0817 0.1282
Loa Loa (eye worm) hypothetical protein 0.0095 0.0249 0.0501
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.005 0.0098
Schistosoma mansoni hypothetical protein 0.0142 0.0398 0.0623
Trypanosoma cruzi tubulin gamma chain 0.0878 0.2704 0.5475
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0031 0.003
Plasmodium vivax glutathione reductase, putative 0.0094 0.0245 0.0495
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0042 0.0085 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0058 0.0135 0.027
Schistosoma mansoni survival motor neuron protein 0.0048 0.0102 0.0159
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0043 0.0085
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0019 0.0027
Loa Loa (eye worm) RGS-3 protein 0.0042 0.0085 0.0171
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0067 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.012 0.0232
Leishmania major alpha tubulin 0.1139 0.352 0.7128
Loa Loa (eye worm) hypothetical protein 0.0058 0.0135 0.027
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0288 0.0573
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0056 0.0114
Brugia malayi MH2 domain containing protein 0.0472 0.1432 0.2899
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0054 0.0107
Loa Loa (eye worm) tubulin alpha chain 0.1139 0.352 0.7128
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0054 0.0387
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0031 0.0062
Leishmania major beta tubulin 0.1592 0.4938 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0157 0.0308
Echinococcus multilocularis tubulin gamma 1 chain 0.0878 0.2704 0.2703
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0014 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0058 0.0135 0.0272
Echinococcus multilocularis smad 0.0032 0.0053 0.0052
Onchocerca volvulus 0.0057 0.0131 0.0826
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0056 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0104 0.0199
Loa Loa (eye worm) PXA domain-containing protein 0.0042 0.0085 0.0171
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0054 0.2101
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0056 0.0114
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0137 0.1129
Leishmania major cytochrome p450-like protein 0.0053 0.0117 0.0235
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0067 0.0066
Echinococcus granulosus regulator of G protein signaling 7 0.0042 0.0085 0.0132
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0135 0.021
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0054 0.0107
Brugia malayi Intermediate filament tail domain containing protein 0.008 0.0202 0.0408
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0079 0.0149
Echinococcus multilocularis regulator of G protein signaling 0.0042 0.0085 0.0084
Loa Loa (eye worm) hypothetical protein 0.0242 0.0711 0.1438
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.0697 0.141
Brugia malayi PXA domain containing protein 0.0042 0.0085 0.0173
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0071 0.011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0058 0.0135 0.0272
Echinococcus multilocularis tubulin delta chain 0.0384 0.1155 0.1154
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0051 0.0112 0.0225
Echinococcus granulosus Niemann Pick C1 protein 0.0193 0.0558 0.0874
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0085 0.0162
Trichomonas vaginalis abcb9, putative 0.0021 0.0019 0.0027
Schistosoma mansoni rab6-interacting 0.0157 0.0444 0.0695
Trichomonas vaginalis tubulin, putative 0.0467 0.1417 0.2861
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0019 0.0028
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0416 0.1256 0.2541
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0157 0.0316
Echinococcus granulosus aryl hydrocarbon receptor 0.005 0.0109 0.017
Loa Loa (eye worm) hypothetical protein 0.0234 0.0686 0.1388
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0054 0.0107
Loa Loa (eye worm) hypothetical protein 0.0058 0.0135 0.027
Brugia malayi sodium-independent organic anion transporter family protein 0.0084 0.0214 0.0434
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0043 0.0076
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0143 0.0287
Leishmania major beta tubulin 0.1592 0.4938 1
Loa Loa (eye worm) raf kinase 0.0043 0.0086 0.0171
Trypanosoma brucei alpha tubulin 0.1139 0.352 0.7128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.012 0.0232
Brugia malayi conserved hypotetical protein 0.0025 0.0031 0.0062
Schistosoma mansoni fkbp-rapamycin associated protein 0.0017 0.0006 0.0007
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0031 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0141 0.0274
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.005 0.0076
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0041 0.0083
Brugia malayi beta-tubulin, identical 0.1592 0.4938 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0053 0.0117 0.0954
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0102 0.0271 0.0547
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0019 0.0027
Brugia malayi intermediate filament protein 0.008 0.0202 0.0408
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1139 0.352 0.7126
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0086 0.0133
Echinococcus multilocularis regulator of G protein signaling 3 0.0042 0.0085 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0058 0.0135 0.0272
Trypanosoma cruzi cytochrome P450, putative 0.0053 0.0117 0.0235
Loa Loa (eye worm) tubulin beta chain 0.1592 0.4938 1
Onchocerca volvulus Putative organic anion transporter 0.0084 0.0214 0.1411
Schistosoma mansoni hypothetical protein 0.0206 0.0596 0.0935
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0057 0.0131 0.0264
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0019 0.0027
Leishmania major beta tubulin 0.1592 0.4938 1
Schistosoma mansoni cpg binding protein 0.006 0.0139 0.0217
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0181 0.018
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0135 0.0272
Schistosoma mansoni smad1 5 8 and 0.0032 0.0053 0.0082
Loa Loa (eye worm) CYP4Cod1 0.0053 0.0117 0.0235
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0041 0.0063
Trichomonas vaginalis guanylate cyclase, putative 0.005 0.0109 0.021
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0031 0.0062
Echinococcus multilocularis tubulin alpha chain 0.1139 0.352 0.352
Trichomonas vaginalis tubulin alpha chain, putative 0.0467 0.1417 0.2861
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0058 0.0135 0.027
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0058 0.0135 0.0209
Leishmania major beta tubulin 0.1592 0.4938 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0157 0.0316
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0054 0.0403
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0021 0.0019 0.0036
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.0245 0.0495
Onchocerca volvulus Putative organic anion transporter 0.0084 0.0214 0.1411
Loa Loa (eye worm) hypothetical protein 0.0157 0.0444 0.0897
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0008 0.0014
Echinococcus granulosus Smad4 0.0032 0.0053 0.0082
Schistosoma mansoni alpha tubulin 0.1139 0.352 0.5525
Brugia malayi Steroid receptor seven-up type 2 0.0058 0.0135 0.0272
Leishmania major delta tubulin, putative 0.0552 0.1681 0.3402
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0058 0.0135 0.0272
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0031 0.0062
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.005 0.0098
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0043 0.0076
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.001 0.0017
Brugia malayi Tubulin alpha-2 chain 0.1139 0.352 0.7129
Schistosoma mansoni rab6-interacting 0.0157 0.0444 0.0695
Toxoplasma gondii endonuclease IV APN 0.0074 0.0186 0.0374
Schistosoma mansoni DNA helicase recq1 0.0028 0.0041 0.0062
Echinococcus multilocularis nuclear receptor nhr 48 0.0025 0.0031 0.003
Echinococcus multilocularis expressed protein 0.0739 0.2269 0.2268
Trichomonas vaginalis tubulin gamma chain, putative 0.0384 0.1155 0.233
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0031 0.006
Brugia malayi photoreceptor-specific nuclear receptor 0.0058 0.0135 0.0272
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.001 0.0008
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0041 0.0062
Echinococcus granulosus beta-adrenergic receptor kinase 0.0043 0.0088 0.0137
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0086 0.0172
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0067 0.0125
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0043 0.0076
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.005 0.0109 0.0219
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0102 0.0271 0.0547
Echinococcus granulosus microtubule associated protein 2 0.2049 0.637 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0755 0.2318 0.4688
Mycobacterium leprae cell division protein FtsZ 0.0384 0.1155 1
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0271 0.0424
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0057 0.0131 0.0264
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.006
Echinococcus multilocularis CREB binding protein 0.0033 0.0056 0.0055
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0008 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0176 0.0345
Echinococcus granulosus peroxisome assembly protein 26 0.1139 0.352 0.5525
Entamoeba histolytica tubulin alpha chain, putative 0.1139 0.352 0.7126
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0034 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0058 0.0135 0.0272
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0019 0.0027
Brugia malayi 6-phosphofructokinase 0.0107 0.0288 0.0584
Onchocerca volvulus 0.0025 0.0031 0.0118
Brugia malayi tailless protein 0.0025 0.0031 0.0062
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.001 0.0017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0056 0.0087
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0196 0.0567 0.0889
Loa Loa (eye worm) hypothetical protein 0.0042 0.0085 0.0171
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0043 0.0088 0.0177
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0084 0.0214 0.0213
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0054 0.0107
Schistosoma mansoni single-minded 0.0192 0.0555 0.087
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0031 0.0046
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.006
Toxoplasma gondii target of rapamycin (TOR), putative 0.0067 0.0161 0.0324
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0031 0.0062
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0042 0.0085 0.0084
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0054 0.0403
Trichomonas vaginalis tubulin epsilon chain, putative 0.1592 0.4938 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0123
Leishmania major trypanothione reductase 0.0094 0.0245 0.0495
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0014 0.0028
Trichomonas vaginalis tubulin, putative 0.0467 0.1417 0.2861
Echinococcus granulosus regulator of G protein signaling 3 0.0042 0.0085 0.0132
Giardia lamblia Beta tubulin 0.1592 0.4938 1
Echinococcus multilocularis protein dispatched 1 0.0095 0.0249 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0088 0.0137
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0237 0.0695 0.5996
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0058 0.0135 0.027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0003 0.0003
Leishmania major protein kinase, putative 0.0051 0.0112 0.0225
Entamoeba histolytica hypothetical protein 0.0042 0.0085 0.0162
Leishmania major alpha tubulin 0.1139 0.352 0.7128
Loa Loa (eye worm) hypothetical protein 0.0084 0.0214 0.0432
Schistosoma mansoni tubulin subunit alpha 0.0384 0.1155 0.1811
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0102 0.0271 0.0547
Echinococcus multilocularis aryl hydrocarbon receptor 0.005 0.0109 0.0108
Echinococcus granulosus dnaJ subfamily B 0.0803 0.2467 0.3872
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0213 0.0621 0.5345
Trypanosoma cruzi beta tubulin, putative 0.1592 0.4938 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0003 0.0002
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0067 0.0104
Brugia malayi nuclear hormone receptor 0.0025 0.0031 0.0062
Schistosoma mansoni tubulin subunit beta 0.1592 0.4938 0.7752
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0142 0.0398 0.0397
Loa Loa (eye worm) alpha-tubulin 0.1139 0.352 0.7128
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0088 0.0137
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.001 0.0017
Schistosoma mansoni ap endonuclease 0.0018 0.001 0.0013
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0626 0.1914 0.1913
Loa Loa (eye worm) hypothetical protein 0.0084 0.0214 0.0432
Loa Loa (eye worm) hypothetical protein 0.008 0.0202 0.0406
Mycobacterium ulcerans cell division protein FtsZ 0.0384 0.1155 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0058 0.0135 0.027
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.005 0.0109 0.0219
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0058 0.0135 0.0209
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0288 0.0573
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0157 0.0245
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0053 0.0106
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0067 0.0066
Loa Loa (eye worm) pax transcription factor protein 2 0.0238 0.0699 0.1414
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0157 0.0316
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0011
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0084 0.0214 0.0213
Onchocerca volvulus 0.0084 0.0214 0.1411
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.001 0.0016
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0288 0.0451
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0058 0.0135 0.0272
Trypanosoma cruzi epsilon tubulin, putative 0.0878 0.2703 0.5472
Trichomonas vaginalis tubulin gamma chain, putative 0.0878 0.2704 0.5471
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0058 0.0135 0.0272
Schistosoma mansoni retinoic acid receptor RXR 0.0058 0.0135 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0384 0.1155 0.233
Echinococcus granulosus Tubulin alpha 1 chain 0.1139 0.352 0.5525
Brugia malayi phosphofructokinase 0.0107 0.0288 0.0584
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.0245 0.2072
Brugia malayi CXXC zinc finger family protein 0.0056 0.0129 0.0261
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0288 0.0573
Brugia malayi cytochrome P450 0.0018 0.0008 0.0016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.005 0.0048
Schistosoma mansoni zinc finger protein 0.0025 0.0031 0.0046
Brugia malayi hypothetical protein 0.0042 0.0085 0.0173
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0058 0.0135 0.0272
Loa Loa (eye worm) alpha-tubulin 0.1139 0.352 0.7128
Trypanosoma cruzi epsilon tubulin, putative 0.0878 0.2703 0.5472
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0019 0.0018
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0049 0.0096
Echinococcus granulosus Tubulin alpha 1 chain 0.1139 0.352 0.5525
Echinococcus multilocularis dnaJ subfamily B 0.0803 0.2467 0.2466
Trichomonas vaginalis tubulin alpha chain, putative 0.0467 0.1417 0.2861
Schistosoma mansoni cellular tumor antigen P53 0.0197 0.057 0.0894
Brugia malayi multidrug resistance protein 3 0.0021 0.0019 0.0038
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0058 0.0135 0.0209
Echinococcus multilocularis tubulin alpha 3 chain 0.1139 0.352 0.352
Leishmania major beta tubulin 0.1592 0.4938 1
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0019 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0233 0.0461
Loa Loa (eye worm) transcription factor SMAD2 0.0472 0.1432 0.2898
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0192 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0135 0.0262
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0056 0.0112
Brugia malayi Cytochrome P450 family protein 0.0018 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0033 0.0056 0.0112
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.005 0.0109 0.021
Schistosoma mansoni tubulin subunit beta 0.1592 0.4938 0.7752
Loa Loa (eye worm) hypothetical protein 0.0042 0.0085 0.0171
Leishmania major beta tubulin 0.1592 0.4938 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.009 0.0233 0.047
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.0686 0.1076
Echinococcus multilocularis regulator of G protein signaling 7 0.0042 0.0085 0.0084
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.001 0.0008
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0672 0.2056 0.4157
Echinococcus granulosus neuropeptide s receptor 0.0909 0.28 0.4395
Trichomonas vaginalis tubulin gamma chain, putative 0.0878 0.2703 0.5468
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0043 0.0085
Trichomonas vaginalis taga, putative 0.0021 0.0019 0.0027
Loa Loa (eye worm) multidrug resistance protein 3 0.0021 0.0019 0.0036
Echinococcus granulosus RUN 0.0157 0.0444 0.0695
Brugia malayi Tubulin alpha-2 chain 0.1139 0.352 0.7129
Echinococcus granulosus tubulin beta 4A class IVa 0.1592 0.4938 0.7752
Loa Loa (eye worm) hypothetical protein 0.0672 0.2056 0.4162
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0043 0.0085
Brugia malayi secreted modular calcium-binding protein 1 0.0057 0.0131 0.0266
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.005 0.0109 0.021
Onchocerca volvulus 0.008 0.0202 0.1321
Loa Loa (eye worm) tubulin beta-2A chain 0.1592 0.4938 1
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0014 0.0052
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0176 0.0345
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0135 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0104 0.02
Brugia malayi PAS domain containing protein 0.0192 0.0555 0.1124
Trichomonas vaginalis tubulin, putative 0.0411 0.124 0.2502
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0058 0.0135 0.027
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0019 0.0028
Brugia malayi nuclear receptor NHR-88 0.0058 0.0135 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0058 0.0135 0.0272
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0008 0.0014
Leishmania major epsilon tubulin, putative 0.0878 0.2703 0.5472
Trypanosoma cruzi MFS transporter, putative 0.0084 0.0214 0.0432
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0552 0.1681 0.3402
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0043 0.0068
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0058 0.0135 0.0209
Echinococcus granulosus mitogen activated protein kinase 3 0.0102 0.0271 0.0424
Echinococcus granulosus axis inhibition protein axin 0.0042 0.0085 0.0132
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0213 0.0621 0.5345
Schistosoma mansoni jun-related protein 0.0135 0.0375 0.0587
Loa Loa (eye worm) hypothetical protein 0.0084 0.0214 0.0432
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.009 0.0233 0.0461
Brugia malayi MAP kinase sur-1 0.0102 0.0271 0.0549
Echinococcus granulosus tubulin alpha chain 0.1139 0.352 0.5525
Echinococcus granulosus tubulin subunit TubB 0.1139 0.352 0.5525
Brugia malayi nuclear receptor RXR 0.0025 0.0031 0.0062
Schistosoma mansoni nuclear receptor 0.0025 0.0031 0.0046
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0137 0.0276
Mycobacterium ulcerans epimerase 0.002 0.0014 0.0052
Chlamydia trachomatis endonuclease IV 0.0074 0.0186 1
Echinococcus granulosus ecdysone induced protein 78C 0.0058 0.0135 0.0209
Echinococcus multilocularis serine protein kinase ATM 0.0017 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0021
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0054 0.0053
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0019 0.0027
Loa Loa (eye worm) nuclear factor I 0.0018 0.0008 0.0014
Echinococcus granulosus bloom syndrome protein 0.004 0.0079 0.0122
Loa Loa (eye worm) hypothetical protein 0.0037 0.0068 0.0136
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.006
Giardia lamblia Delta tubulin 0.0384 0.1155 0.2323
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.001 0.002
Trichomonas vaginalis DNA helicase recq1, putative 0.004 0.0079 0.0149
Trichomonas vaginalis tubulin beta chain, putative 0.1139 0.352 0.7126
Plasmodium falciparum glutathione reductase 0.0032 0.0054 0.0107
Echinococcus multilocularis follistatin 0.0057 0.0131 0.013
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0058 0.0135 0.027
Schistosoma mansoni hypothetical protein 0.008 0.0203 0.0317
Loa Loa (eye worm) hypothetical protein 0.0057 0.0131 0.0264
Plasmodium vivax ataxin-2 like protein, putative 0.01 0.0265 0.0534
Echinococcus multilocularis peroxisome assembly protein 26 0.1139 0.352 0.352
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0085 0.0162
Echinococcus granulosus lamin 0.008 0.0202 0.0315
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0041 0.008
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0019 0.0012 0.0021
Trichomonas vaginalis tubulin epsilon chain, putative 0.1592 0.4938 1
Echinococcus multilocularis CREB binding protein 0.0138 0.0385 0.0384
Leishmania major beta tubulin 0.1592 0.4938 1
Schistosoma mansoni tubulin subunit beta 0.1592 0.4938 0.7752
Loa Loa (eye worm) tubulin gamma chain 0.0878 0.2704 0.5475
Echinococcus granulosus Tubulin beta 2C chain 0.1592 0.4938 0.7752
Echinococcus multilocularis beta tubulin 0.1592 0.4938 0.4938
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0042 0.0085 0.0132
Echinococcus multilocularis neuropeptide receptor A26 0.0909 0.28 0.28
Loa Loa (eye worm) tubulin alpha 2 0.0755 0.2318 0.4693
Brugia malayi hypothetical protein 0.0042 0.0085 0.0173
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0288 0.0451
Brugia malayi CHE-14 protein 0.0083 0.0212 0.043
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0053 0.0082
Leishmania major cytochrome p450-like protein 0.0018 0.0008 0.0014
Brugia malayi sodium-independent organic anion transporter family protein 0.0084 0.0214 0.0434
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0193 0.0558 0.1119
Trichomonas vaginalis tubulin beta chain, putative 0.1139 0.352 0.7126
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0025 0.0031 0.0046
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0057 0.0131 0.0266
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0019 0.0028
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0137 0.1129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0058 0.0135 0.027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0058 0.0135 0.0272
Schistosoma mansoni hypothetical protein 0.008 0.0203 0.0317
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0137 0.0136
Toxoplasma gondii protease inhibitor PI2 0.0057 0.0131 0.0264
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0041 0.008
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0019 0.0036
Brugia malayi PXA domain containing protein 0.0042 0.0085 0.0173
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0074 0.0186 0.1552
Echinococcus granulosus tubulin gamma 1 chain 0.0878 0.2704 0.4244
Trypanosoma brucei epsilon tubulin 0.0878 0.2703 0.5472
Leishmania major alpha tubulin 0.1139 0.352 0.7128
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0021 0.0019 0.0036
Schistosoma mansoni thyroid hormone receptor 0.0058 0.0135 0.0209
Loa Loa (eye worm) hypothetical protein 0.0033 0.0056 0.0112
Echinococcus granulosus Tubulin beta 2C chain 0.1592 0.4938 0.7752
Entamoeba histolytica hypothetical protein 0.0142 0.0398 0.0796
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0019 0.0027
Echinococcus granulosus tubulin alpha chain 0.1139 0.352 0.5525
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0033 0.0056 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0161 0.0315
Brugia malayi MH1 domain containing protein 0.0018 0.0008 0.0017
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0143 0.0142
Echinococcus multilocularis mitogen activated protein kinase 0.0102 0.0271 0.027
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.005 0.0109 0.021
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.0186 0.0374
Brugia malayi ecdysone receptor 0.0025 0.0031 0.0062
Echinococcus multilocularis Tubulin beta 2C chain 0.1592 0.4938 0.4938
Echinococcus multilocularis Tubulin alpha 1 chain 0.1139 0.352 0.352
Trichomonas vaginalis tubulin beta chain, putative 0.1139 0.352 0.7126
Brugia malayi Smad1 0.0032 0.0053 0.0108
Leishmania major alpha tubulin 0.1139 0.352 0.7128
Schistosoma mansoni tubulin subunit gamma 0.0878 0.2704 0.4244
Echinococcus multilocularis tubulin subunit TubB 0.1139 0.352 0.352
Loa Loa (eye worm) tubulin beta chain 0.0384 0.1155 0.2336
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0038 0.0073 0.0072
Brugia malayi hypothetical protein 0.0033 0.0056 0.0114
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0028 0.0054
Trypanosoma brucei zeta tubulin 0.0665 0.2034 0.4118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0143 0.0222
Trypanosoma brucei alpha tubulin 0.1139 0.352 0.7128
Brugia malayi Tubulin alpha chain 0.1139 0.352 0.7129
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.009 0.0233 0.0364
Brugia malayi 6-phosphofructokinase 0.0107 0.0289 0.0586
Trichomonas vaginalis guanylate cyclase, putative 0.005 0.0109 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0085 0.0162
Schistosoma mansoni lamin 0.008 0.0202 0.0315
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0054 0.0107
Echinococcus multilocularis lamin 0.008 0.0202 0.02
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0067 0.0104
Leishmania major alpha tubulin 0.1139 0.352 0.7128
Entamoeba histolytica P-glycoprotein-1 0.0021 0.0019 0.0027
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0019 0.0027
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0053 0.0052
Leishmania major cytochrome p450-like protein 0.0018 0.0008 0.0014
Toxoplasma gondii exonuclease III APE 0.0018 0.001 0.0017
Schistosoma mansoni tubulin subunit beta 0.1592 0.4938 0.7752
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0143 0.0222
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0031 0.006
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.009 0.0233 0.047
Brugia malayi SPARC precursor 0.0057 0.0131 0.0266
Brugia malayi hypothetical protein 0.0025 0.0031 0.0062
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0043 0.0076
Plasmodium vivax tubulin epsilon chain, putative 0.0878 0.2703 0.5472
Trypanosoma cruzi zeta tubulin, putative 0.0665 0.2034 0.4118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0068 0.0136
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.005 0.0098
Schistosoma mansoni lipoxygenase 0.0626 0.1914 0.3003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0054 0.0107
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0157 0.0316
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0057 0.0131 0.0266
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0054 0.0107
Echinococcus multilocularis agrin 0.0057 0.0131 0.013
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.005 0.0048
Echinococcus granulosus Tubulin beta 2C chain 0.1592 0.4938 0.7752
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0137 0.0214
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0019 0.0028
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0288 0.0582
Echinococcus granulosus Regulator of G protein signaling 20 0.0042 0.0085 0.0132
Loa Loa (eye worm) RecQ helicase 0.004 0.0079 0.0158
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0054 0.0107
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0058 0.0135 0.0209
Plasmodium falciparum ataxin-2 like protein, putative 0.01 0.0265 0.0534
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0054 0.0107
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0019 0.0027
Echinococcus granulosus smad 0.0032 0.0053 0.0082
Trichomonas vaginalis tubulin epsilon chain, putative 0.0384 0.1155 0.233
Loa Loa (eye worm) tubulin beta-1 chain 0.1592 0.4938 1
Trypanosoma cruzi tubulin delta chain 0.0552 0.1681 0.3402
Loa Loa (eye worm) hypoxia-induced factor 1 0.0596 0.1818 0.368
Echinococcus multilocularis cpg binding protein 0.006 0.0139 0.0138
Loa Loa (eye worm) hypothetical protein 0.0162 0.0458 0.0926
Loa Loa (eye worm) hypothetical protein 0.0042 0.0085 0.0171
Loa Loa (eye worm) hypothetical protein 0.0084 0.0214 0.0432
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0089 0.0137
Schistosoma mansoni hypothetical protein 0.067 0.2052 0.322
Brugia malayi hypothetical protein 0.0033 0.0056 0.0114
Echinococcus granulosus tubulin delta chain 0.0384 0.1155 0.1811
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0102 0.0271 0.0547
Echinococcus granulosus tubulin alpha 1C chain 0.1139 0.352 0.5525
Echinococcus granulosus regulator of G protein signaling 7 0.0042 0.0085 0.0132
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0085 0.0132
Echinococcus granulosus beta tubulin 0.1592 0.4938 0.7752
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0054 0.0107
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0054 0.0107
Onchocerca volvulus 0.0473 0.1436 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0054 0.0107
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0135 0.0134
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.005 0.0109 0.5404
Echinococcus granulosus beta tubulin 0.1592 0.4938 0.7752
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.008
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.008 0.0202 0.0406
Loa Loa (eye worm) hypothetical protein 0.0042 0.0085 0.0171
Schistosoma mansoni multidrug resistance protein 0.0021 0.0019 0.0028
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0031 0.003
Trichomonas vaginalis tubulin epsilon chain, putative 0.1139 0.352 0.7126
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0056 0.0087
Loa Loa (eye worm) DR-78 0.0025 0.0031 0.006
Brugia malayi bZIP transcription factor family protein 0.0166 0.0473 0.0957
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.005 0.0109 0.021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0058 0.0135 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0047 0.0083
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0058 0.0135 0.0133
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.006
Echinococcus multilocularis tubulin alpha 0.0851 0.2619 0.2618
Mycobacterium ulcerans putative regulatory protein 0.0142 0.0399 0.3407
Trichomonas vaginalis adenylate cyclase, putative 0.005 0.0109 0.021
Loa Loa (eye worm) steroid hormone receptor 0.0058 0.0135 0.027
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0043 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0047 0.0083
Echinococcus multilocularis lipoxygenase domain containing protein 0.0157 0.0444 0.0443
Leishmania major alpha tubulin 0.1139 0.352 0.7128
Loa Loa (eye worm) hypothetical protein 0.0084 0.0214 0.0432
Echinococcus multilocularis tubulin alpha chain 0.1139 0.352 0.352
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.0245 0.0495
Loa Loa (eye worm) agrin synaptic family protein 0.0057 0.0131 0.0264
Echinococcus multilocularis jun protein 0.0166 0.0473 0.0472
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0233 0.0472
Trypanosoma brucei zeta tubulin, putative 0.0665 0.2034 0.4118
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0135 0.021
Plasmodium falciparum ataxin-2 like protein, putative 0.01 0.0265 0.0534
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0137 0.0276
Echinococcus multilocularis Tubulin beta 2C chain 0.1592 0.4938 0.4938
Echinococcus granulosus Tubulin alpha 1 chain 0.1139 0.352 0.5525
Onchocerca volvulus Putative organic anion transporter 0.0084 0.0214 0.1411
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0027 0.0055
Brugia malayi Bloom's syndrome protein homolog 0.004 0.0079 0.016
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0047 0.0092
Echinococcus granulosus Tubulin beta 2C chain 0.1592 0.4938 0.7752
Brugia malayi Thioredoxin reductase 0.0094 0.0245 0.0497
Echinococcus granulosus alpha tubulin 0.1139 0.352 0.5525
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0213 0.0621 0.5345
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0058 0.0135 0.027
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.001 0.0017
Schistosoma mansoni axis inhibition protein axin 0.0042 0.0085 0.0132
Schistosoma mansoni hypothetical protein 0.067 0.2052 0.322
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0288 0.0287
Echinococcus multilocularis tubulin alpha 1C chain 0.1139 0.352 0.352
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0031 0.0046
Mycobacterium leprae Possible regulatory protein 0.005 0.0109 0.0883
Brugia malayi nuclear hormone receptor 0.0058 0.0135 0.0272
Loa Loa (eye worm) hypothetical protein 0.0078 0.0197 0.0397
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0054 0.0107
Echinococcus granulosus thyroid hormone receptor alpha 0.0025 0.0031 0.0046
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0036
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0009
Brugia malayi hypothetical protein 0.0157 0.0444 0.0899
Schistosoma mansoni hypothetical protein 0.0157 0.0444 0.0695
Onchocerca volvulus 0.0084 0.0214 0.1411
Leishmania major hypothetical protein, conserved 0.01 0.0265 0.0534
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0019 0.0027
Brugia malayi MH1 domain containing protein 0.0032 0.0053 0.0108
Entamoeba histolytica tubulin family protein 0.1592 0.4938 1
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0288 0.0573
Echinococcus granulosus follistatin 0.0057 0.0131 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0012 0.0012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0003 0.0003
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.001 0.0016
Loa Loa (eye worm) tubulin alpha chain 0.1139 0.352 0.7128
Trypanosoma brucei trypanothione reductase 0.0094 0.0245 0.0495
Echinococcus granulosus Protein patched homolog 1 0.0083 0.0212 0.0331
Echinococcus multilocularis RUN 0.0157 0.0444 0.0443
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0058 0.0135 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0176 0.0345
Loa Loa (eye worm) hypothetical protein 0.0038 0.0073 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0109 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0047 0.0083
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0137 0.0214
Echinococcus multilocularis sterol regulatory element binding protein 0.0083 0.0212 0.0211
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0117 0.0235
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0237 0.0695 0.5996
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0047 0.0092
Echinococcus multilocularis beta adrenergic receptor kinase 0.0043 0.0088 0.0087
Brugia malayi hypothetical protein 0.0084 0.0214 0.0434
Echinococcus granulosus tubulin epsilon chain 0.0878 0.2703 0.4242
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0102 0.0271 0.0547
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.0135 0.0133
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0045 0.0093 0.0144
Loa Loa (eye worm) hypothetical protein 0.0042 0.0085 0.0171
Brugia malayi hypothetical protein 0.01 0.0265 0.0536
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.0334 0.0522
Schistosoma mansoni hypothetical protein 0.008 0.0203 0.0317
Mycobacterium tuberculosis Cell division protein FtsZ 0.0384 0.1155 1
Plasmodium vivax tubulin alpha chain, putative 0.1139 0.352 0.7128
Mycobacterium ulcerans endonuclease IV 0.0074 0.0186 0.1552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0118 0.0229
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0117 0.0235
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0288 0.2447
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0271 0.0539
Loa Loa (eye worm) hypothetical protein 0.0058 0.0135 0.027
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0003 0.0003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0003 0.0002
Plasmodium vivax tubulin alpha chain, putative 0.1139 0.352 0.7128
Schistosoma mansoni tubulin subunit beta 0.1592 0.4938 0.7752
Echinococcus multilocularis lamin dm0 0.008 0.0202 0.02
Leishmania major beta tubulin 0.1592 0.4938 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0041 0.0083
Schistosoma mansoni cpg binding protein 0.006 0.0139 0.0217
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0102 0.0207
Schistosoma mansoni tubulin subunit alpha 0.1139 0.352 0.5525
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0201 0.0583 0.0914
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.005 0.0109 0.0108
Echinococcus granulosus tubulin alpha chain 0.1139 0.352 0.5525
Brugia malayi Regulator of G protein signaling domain containing protein 0.0042 0.0085 0.0173
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0057 0.0131 0.0266
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0056 0.0055
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0067 0.0134
Brugia malayi nuclear receptor RXR 0.0033 0.0056 0.0114
Leishmania major beta tubulin 0.1592 0.4938 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0071 0.0176 0.0354
Trypanosoma cruzi PAB1-binding protein , putative 0.01 0.0265 0.0534
Onchocerca volvulus 0.013 0.0361 0.2441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0161 0.0315
Loa Loa (eye worm) BEN-1 protein 0.1592 0.4938 1
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0085 0.0132
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0245 0.0244
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0043 0.0293
Onchocerca volvulus 0.0467 0.1417 0.9868
Schistosoma mansoni z-protein (S1r protein) 0.0042 0.0085 0.0132
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.009 0.0233 0.047
Trichomonas vaginalis tubulin, putative 0.1592 0.4938 1
Trypanosoma brucei tubulin gamma chain 0.0878 0.2704 0.5475
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.001 0.0017
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0036
Trichomonas vaginalis tubulin beta chain, putative 0.0467 0.1417 0.2861
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0176 0.0345
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0085 0.0162
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0084 0.0214 0.0335
Loa Loa (eye worm) BEN-1 protein 0.1592 0.4938 1
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0043 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0104 0.02
Echinococcus multilocularis axis inhibition protein axin 0.0042 0.0085 0.0084
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0019 0.0018
Echinococcus granulosus CREB binding protein 0.0124 0.0341 0.0534
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0054 0.0403
Brugia malayi Regulator of G protein signaling domain containing protein 0.0042 0.0085 0.0173
Onchocerca volvulus 0.0084 0.0214 0.1411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0104 0.02
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0019 0.0027
Echinococcus multilocularis CREB binding protein 0.0033 0.0056 0.0055
Entamoeba histolytica P-glycoprotein-5 0.0021 0.0019 0.0027
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.005 0.0048
Loa Loa (eye worm) glutathione reductase 0.0094 0.0245 0.0495
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0054 0.0083
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0031 0.0046
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0245 0.0495
Trypanosoma brucei epsilon tubulin 0.0851 0.2619 0.5302
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.006
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0047 0.0092
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0017
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0008 0.0014
Brugia malayi sodium-independent organic anion transporter family protein 0.0084 0.0214 0.0434
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0074 0.0186 0.0376
Schistosoma mansoni hypothetical protein 0.008 0.0203 0.0317
Brugia malayi Tubulin beta chain 0.0467 0.1417 0.2869
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0143 0.0222
Loa Loa (eye worm) hypothetical protein 0.0042 0.0085 0.0171
Loa Loa (eye worm) hypothetical protein 0.0083 0.0212 0.0428
Echinococcus multilocularis geminin 0.067 0.2052 0.2051
Mycobacterium tuberculosis Probable reductase 0.0213 0.0621 0.5345
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0071 0.0176 0.0354
Echinococcus granulosus tubulin beta 1 chain 0.1592 0.4938 0.7752
Onchocerca volvulus 0.0238 0.0699 0.4822
Brugia malayi hypothetical protein 0.0025 0.0031 0.0062
Toxoplasma gondii LsmAD domain-containing protein 0.01 0.0265 0.0534
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0041 0.008
Schistosoma mansoni coup transcription factor 0.0058 0.0135 0.0209
Brugia malayi prostaglandin transporter 0.0084 0.0214 0.0434
Echinococcus multilocularis Niemann Pick C1 protein 0.0193 0.0558 0.0557
Trypanosoma brucei cytochrome P450, putative 0.0053 0.0117 0.0235
Trypanosoma cruzi cytochrome P450, putative 0.0053 0.0117 0.0235
Giardia lamblia GTOR 0.009 0.0233 0.0453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0161 0.0315
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0041 0.0062
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0054 0.009
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0019 0.0028
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.006
Brugia malayi regulator of G-protein signaling rgs-7 0.0042 0.0085 0.0173
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0019 0.0027
Brugia malayi Tubulin beta-1 chain 0.1592 0.4938 1
Plasmodium vivax SET domain protein, putative 0.0061 0.0143 0.0287
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0047 0.0092
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0008 0.0014
Trypanosoma brucei alpha tubulin, putative 0.0467 0.1417 0.2867
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0058 0.0135 0.0272
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0043 0.1456
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0145 0.0226
Echinococcus multilocularis Tubulin beta 2C chain 0.1592 0.4938 0.4938
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0157 0.0316
Toxoplasma gondii FATC domain-containing protein 0.0017 0.0006 0.0009
Echinococcus granulosus regulator of G protein signaling 3 0.0042 0.0085 0.0132
Leishmania major alpha tubulin 0.1139 0.352 0.7128
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0051 0.0112 0.0225
Trypanosoma brucei PAB1-binding protein , putative 0.01 0.0265 0.0534
Entamoeba histolytica hypothetical protein 0.0042 0.0085 0.0162
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0157 0.0245
Brugia malayi nuclear receptor NHR-88 0.0025 0.0031 0.0062
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0031 0.0046
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0021 0.0019 0.0036
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0071 0.0176 0.0354
Brugia malayi A-kinase anchor protein 10, precursor 0.0042 0.0085 0.0173
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0058 0.0135 0.0133
Echinococcus multilocularis raf serine:threonine protein kinase 0.0043 0.0086 0.0085
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0042 0.0085 0.0171
Brugia malayi ABC transporter family protein 0.0021 0.0019 0.0038
Echinococcus granulosus Solute carrier organic anion transporter family 0.0084 0.0214 0.0335
Entamoeba histolytica hypothetical protein 0.0042 0.0085 0.0162
Echinococcus granulosus tubulin alpha chain 0.1139 0.352 0.5525
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0028 0.0045
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.005 0.0364
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0411 0.1239 0.2506
Trypanosoma brucei protein kinase, putative 0.0102 0.0271 0.0547
Giardia lamblia Beta tubulin 0.1592 0.4938 1
Schistosoma mansoni organic anion transporter 0.0084 0.0214 0.0335
Echinococcus multilocularis neuropeptide s receptor 0.0909 0.28 0.28
Trichomonas vaginalis tubulin beta chain, putative 0.1139 0.352 0.7126
Brugia malayi TAZ zinc finger family protein 0.0201 0.0583 0.1181
Echinococcus granulosus Tubulin beta 2C chain 0.1592 0.4938 0.7752
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0054 0.0107
Trichomonas vaginalis abcb9, putative 0.0021 0.0019 0.0027
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0047 0.0092
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.0135 0.0209
Schistosoma mansoni cpg binding protein 0.0056 0.0129 0.0201
Trichomonas vaginalis tubulin epsilon chain, putative 0.1139 0.352 0.7126
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0035
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0145 0.0226
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0019 0.0027
Echinococcus multilocularis FTZ F1 alpha 0.0058 0.0135 0.0133
Loa Loa (eye worm) hypothetical protein 0.0084 0.0214 0.0432
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0031 0.0046
Entamoeba histolytica P-glycoprotein-2, putative 0.0021 0.0019 0.0027
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0242 0.0711 0.1438
Brugia malayi hypothetical protein 0.0142 0.0398 0.0807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.012 0.0232
Loa Loa (eye worm) hypothetical protein 0.1139 0.352 0.7128
Loa Loa (eye worm) hypothetical protein 0.0058 0.0135 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0233 0.0461
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0019 0.0027
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0288 0.0451
Echinococcus multilocularis tubulin alpha chain 0.1139 0.352 0.352
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0019 0.0018
Echinococcus granulosus jun protein 0.0166 0.0473 0.074
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0017 0.0006 0.0004
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0043 0.0085
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0051 0.0112 0.0225
Brugia malayi tubulin alpha-2 chain 0.1139 0.352 0.7129
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0142 0.0398 0.0623
Brugia malayi hypothetical protein 0.0064 0.0154 0.0312
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.006
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0145 0.0292
Loa Loa (eye worm) MH2 domain-containing protein 0.0472 0.1432 0.2898
Loa Loa (eye worm) hypothetical protein 0.0033 0.0056 0.0112
Trichomonas vaginalis tubulin beta chain, putative 0.1592 0.4938 1
Echinococcus granulosus CREB binding protein 0.0201 0.0583 0.0914
Leishmania major alpha tubulin 0.1139 0.352 0.7128
Brugia malayi hypothetical protein 0.0646 0.1975 0.3999
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0057 0.0131 0.0266
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0086 0.0174
Leishmania major beta tubulin 0.1592 0.4938 1
Schistosoma mansoni alpha tubulin 0.1139 0.352 0.5525
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0047 0.0083
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0271 0.0539
Brugia malayi steroid hormone receptor 0.0058 0.0135 0.0272
Loa Loa (eye worm) doublecortin family protein 0.0157 0.0444 0.0897
Plasmodium falciparum tubulin delta chain, putative 0.0384 0.1155 0.2336
Echinococcus multilocularis thyroid hormone receptor alpha 0.0058 0.0135 0.0133
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0006 0.0011
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0054 0.0107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0031 0.0046
Trypanosoma brucei epsilon tubulin 0.0878 0.2703 0.5472
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0288 0.0582
Leishmania major beta tubulin 0.1592 0.4938 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0137 0.1129
Schistosoma mansoni thyroid hormone receptor 0.0058 0.0135 0.0209
Onchocerca volvulus 0.0056 0.0129 0.081
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0054 0.0083
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0181 0.0282
Loa Loa (eye worm) histone methyltransferase 0.002 0.0014 0.0026
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.009 0.0233 0.047
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0058 0.0135 0.0133
Onchocerca volvulus 0.008 0.0202 0.1321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0118 0.0229
Trichomonas vaginalis tubulin beta chain, putative 0.1139 0.352 0.7126
Brugia malayi glutathione reductase 0.0094 0.0245 0.0497
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0143 0.0222
Echinococcus granulosus serine protein kinase ATM 0.0017 0.0006 0.0007
Brugia malayi alpha-tubulin 0.1139 0.352 0.7129
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0102 0.0271 0.0547
Echinococcus multilocularis tubulin alpha 3 chain 0.1139 0.352 0.352
Brugia malayi MH2 domain containing protein 0.0032 0.0053 0.0108
Leishmania major p-glycoprotein 0.0021 0.0019 0.0036
Brugia malayi Cytochrome P450 family protein 0.0053 0.0117 0.0238
Entamoeba histolytica tubulin family protein 0.1592 0.4938 1
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0054 0.0107
Echinococcus multilocularis Smad4 0.0032 0.0053 0.0052
Echinococcus granulosus tubulin subunit beta 0.1592 0.4938 0.7752
Echinococcus granulosus tubulin alpha 1C chain 0.1139 0.352 0.5525
Brugia malayi Tubulin alpha chain 0.0384 0.1155 0.2338
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0288 0.0573
Leishmania major alpha tubulin 0.1139 0.352 0.7128
Loa Loa (eye worm) Smad1 0.0032 0.0053 0.0106
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0212 0.0419
Treponema pallidum NADH oxidase 0.0032 0.0054 0.0387
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.001 0.0017
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0288 0.2434
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0288 0.0582
Schistosoma mansoni CREB-binding protein 2 0.0201 0.0583 0.0914
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0069 0.0137
Brugia malayi Niemann-Pick C1 protein precursor 0.0193 0.0558 0.1129
Echinococcus granulosus tumor protein p63 0.1348 0.4174 0.6551
Echinococcus multilocularis regulator of G protein signaling 3 0.0042 0.0085 0.0084
Leishmania major beta tubulin 0.1592 0.4938 1
Loa Loa (eye worm) hypothetical protein 0.0197 0.057 0.1153
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0054 0.0107
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.005 0.0098
Plasmodium vivax multidomain scavenger receptor, putative 0.0157 0.0444 0.0897
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0043 0.1456
Mycobacterium tuberculosis Probable dehydrogenase 0.0213 0.0621 0.5345
Trypanosoma brucei beta tubulin 0.1592 0.4938 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0192 0.0555 0.087
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.005 0.0098
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0019 0.0027
Onchocerca volvulus 0.0157 0.0444 0.3026
Loa Loa (eye worm) hypothetical protein 0.0193 0.0558 0.1127
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.005 0.0109 0.017
Loa Loa (eye worm) hypothetical protein 0.0058 0.0135 0.027
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0008 0.0014
Echinococcus granulosus tubulin alpha 0.0851 0.2619 0.411
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0213 0.0621 0.5345
Onchocerca volvulus Huntingtin homolog 0.0242 0.0711 0.4906
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0019 0.0027
Plasmodium falciparum multidrug resistance protein 1 0.0021 0.0019 0.0036
Trichomonas vaginalis tubulin gamma chain, putative 0.1592 0.4938 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0031 0.006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0143 0.0222
Giardia lamblia Alpha-tubulin 0.1139 0.352 0.7123
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.009 0.0233 0.0232
Plasmodium falciparum LCCL domain-containing protein 0.0157 0.0444 0.0897
Trypanosoma brucei alpha tubulin 0.1139 0.352 0.7128
Trypanosoma cruzi zeta tubulin, putative 0.0665 0.2034 0.4118
Onchocerca volvulus 0.0048 0.0102 0.0621
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0157 0.0156
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0025 0.0031 0.003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.005 0.0048
Giardia lamblia Alpha-tubulin 0.1139 0.352 0.7123
Schistosoma mansoni Smad4 0.0032 0.0053 0.0082
Leishmania major beta tubulin 0.1592 0.4938 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0043 0.0088 0.0179
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0067 0.0134
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0019 0.0027
Schistosoma mansoni patched 1 0.0083 0.0212 0.0331
Entamoeba histolytica hypothetical protein 0.0142 0.0398 0.0796
Brugia malayi jmjC domain containing protein 0.0061 0.0145 0.0294
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0467 0.1417 0.2861
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0067 0.0104
Toxoplasma gondii alpha tubulin TUBA1 0.1139 0.352 0.7128
Brugia malayi hypothetical protein 0.0084 0.0214 0.0434
Schistosoma mansoni transcription factor LCR-F1 0.0142 0.0398 0.0623
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0047 0.0092
Echinococcus multilocularis Niemann Pick C1 protein 0.0276 0.0817 0.0816
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0054 0.0107
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0071 0.007
Schistosoma mansoni intermediate filament proteins 0.008 0.0202 0.0315
Brugia malayi Tubulin beta chain 0.0384 0.1155 0.2338
Brugia malayi regulator of G-protein signaling egl-10 0.0042 0.0085 0.0173
Echinococcus multilocularis tubulin alpha chain 0.1139 0.352 0.352
Loa Loa (eye worm) hypothetical protein 0.0755 0.2318 0.4693
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0054 0.0387
Echinococcus multilocularis lipoxygenase domain containing protein 0.0157 0.0444 0.0443
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.0134
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0017 0.0006 0.0009
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0053 0.0106
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0002
Echinococcus granulosus single minded 2 0.0142 0.0399 0.0624
Echinococcus granulosus nuclear receptor nhr 48 0.0025 0.0031 0.0046
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0102 0.0271 0.0547
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0058 0.0135 0.0209
Schistosoma mansoni tubulin subunit beta 0.0384 0.1155 0.1811
Onchocerca volvulus 0.0058 0.0135 0.0849
Onchocerca volvulus Huntingtin homolog 0.0242 0.0711 0.4906
Trypanosoma brucei alpha tubulin 0.1139 0.352 0.7128
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0143 0.0142
Schistosoma mansoni smad1 5 8 and 0.0032 0.0053 0.0082
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.005 0.0098
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.009 0.0233 0.0364
Echinococcus granulosus mitogen activated protein kinase 0.0102 0.0271 0.0424
Brugia malayi hypoxia-induced factor 1 0.0596 0.1818 0.3682
Plasmodium falciparum tubulin epsilon chain, putative 0.0878 0.2703 0.5472
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0049 0.0096
Brugia malayi Pax transcription factor protein 2 0.0238 0.0699 0.1416
Giardia lamblia Epsilon tubulin 0.0411 0.1239 0.2493
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0017 0.0006 0.0007
Schistosoma mansoni DNA helicase recq5 0.0028 0.0041 0.0062
Loa Loa (eye worm) hypothetical protein 0.0058 0.0135 0.027
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0157 0.0319
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0031 0.0118
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0019 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0104 0.0199
Trypanosoma cruzi alpha tubulin, putative 0.1139 0.352 0.7128
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.0135 0.0133
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0058 0.0135 0.0209
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0042 0.0085 0.0132
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0049 0.0087
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.005 0.0098
Onchocerca volvulus 0.005 0.0109 0.067
Toxoplasma gondii thioredoxin reductase 0.0094 0.0245 0.0495
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1592 0.4938 0.4938
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.006
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0041 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0384 0.1155 0.233
Schistosoma mansoni tubulin subunit epsilon 0.0878 0.2703 0.4242
Toxoplasma gondii beta tubulin 0.1592 0.4938 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0851 0.2619 0.5302
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0245 0.0384
Echinococcus multilocularis tubulin alpha 1C chain 0.1139 0.352 0.352
Onchocerca volvulus 0.0025 0.0031 0.0118
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0011 0.001
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.005 0.0098
Loa Loa (eye worm) hypothetical protein 0.0058 0.0135 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0085 0.0162
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0031 0.0062
Loa Loa (eye worm) hypothetical protein 0.0084 0.0214 0.0432
Treponema pallidum cell division protein FtsZ 0.0384 0.1155 1
Echinococcus multilocularis expressed protein 0.0057 0.0131 0.013
Plasmodium falciparum alpha tubulin 2 0.1139 0.352 0.7128
Schistosoma mansoni hypothetical protein 0.0135 0.0375 0.0587
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0084 0.0214 0.0432
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0031 0.0118
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0019 0.0027
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0083 0.0212 0.0428
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0019 0.0027
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0054 0.0107
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0019 0.0027
Schistosoma mansoni smdr2 0.0021 0.0019 0.0028
Echinococcus multilocularis microtubule associated protein 2 0.2049 0.637 0.637
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.001 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0104 0.02
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0054 0.0098
Entamoeba histolytica tubulin gamma chain 0.0878 0.2704 0.5471
Schistosoma mansoni smad 0.0032 0.0053 0.0082
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0233 0.047
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0017 0.0006 0.0007
Loa Loa (eye worm) beta-tubulin 0.1592 0.4938 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0014 0.002
Onchocerca volvulus 0.0084 0.0214 0.1411
Echinococcus multilocularis regulator of G protein signaling 7 0.0042 0.0085 0.0084
Loa Loa (eye worm) tubulin alpha 2 0.0755 0.2318 0.4693
Trichomonas vaginalis tubulin alpha chain, putative 0.0851 0.2619 0.5298
Echinococcus granulosus expressed protein 0.0739 0.2269 0.356
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0017 0.0006 0.0009
Schistosoma mansoni follistatin 0.0057 0.0131 0.0204
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0021 0.0018 0.0027
Schistosoma mansoni tubulin subunit delta 0.0384 0.1155 0.1811
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0058 0.0135 0.0209
Loa Loa (eye worm) tubulin beta-4 chain 0.1592 0.4938 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0006 0.0011
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0051 0.0112 0.0225
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0058 0.0135 0.0209

Activities

Activity type Activity value Assay description Source Reference
Cures (functional) = 1 Suppressive blood schizonticidal antimalarial activity evaluated in the trophozoite-induced Plasmodium berghei infection in mice at a dose 10 mg/kg given as no. of cures ChEMBL. 3599024
Cures (functional) = 1 Suppressive blood schizonticidal antimalarial activity evaluated in the trophozoite-induced Plasmodium berghei infection in mice at a dose 5 mg/kg given as no. of cures ChEMBL. 3599024
Cures (functional) = 3 Suppressive blood schizonticidal antimalarial activity evaluated in the trophozoite-induced Plasmodium berghei infection in mice at a dose 20 mg/kg given as no. of cures ChEMBL. 3599024
Cures (functional) = 1 Suppressive blood schizonticidal antimalarial activity evaluated in the trophozoite-induced Plasmodium berghei infection in mice at a dose 5 mg/kg given as no. of cures ChEMBL. 3599024
Cures (functional) = 1 Suppressive blood schizonticidal antimalarial activity evaluated in the trophozoite-induced Plasmodium berghei infection in mice at a dose 10 mg/kg given as no. of cures ChEMBL. 3599024
Cures (functional) = 3 Suppressive blood schizonticidal antimalarial activity evaluated in the trophozoite-induced Plasmodium berghei infection in mice at a dose 20 mg/kg given as no. of cures ChEMBL. 3599024
Cures/no. of animals (functional) = 0 Radical curative antimalarial activity against Plasmodium cynomolgi in rhesus monkeys expressed as number of cures/no. of animals at a daily dose of 0.1 mg/kg (x7); 0/2 ChEMBL. 3599024
Cures/no. of animals (functional) = 1 Radical curative antimalarial activity against Plasmodium cynomolgi in rhesus monkeys expressed as number of cures/no. of animals at a daily dose of 1 mg/kg (x7); 1/1 ChEMBL. 3599024
Cures/no. of animals (functional) = 2 Radical curative antimalarial activity against Plasmodium cynomolgi in rhesus monkeys expressed as number of cures/no. of animals at a daily dose of 0.316 mg/kg (x7); 2/2 ChEMBL. 3599024
Delta MST (functional) = 6 Suppressive blood schizonticidal antimalarial activity evaluated in the trophozoite-induced Plasmodium berghei infection in mice at a dose 2.5 mg/kg ChEMBL. 3599024
Delta MST (functional) = 6 Suppressive blood schizonticidal antimalarial activity evaluated in the trophozoite-induced Plasmodium berghei infection in mice at a dose 2.5 mg/kg ChEMBL. 3599024
Toxic deaths (ADMET) = 3 Suppressive blood schizonticidal antimalarial activity evaluated in the trophozoite-induced Plasmodium berghei infection in mice at a dose 40 mg/kg given as no. of toxic deaths ChEMBL. 3599024
Toxic deaths (functional) = 5 Suppressive blood schizonticidal antimalarial activity evaluated in the trophozoite-induced Plasmodium berghei infection in mice at a dose 160 mg/kg given as no. of toxic deaths ChEMBL. 3599024
Toxic deaths (ADMET) = 5 Suppressive blood schizonticidal antimalarial activity evaluated in the trophozoite-induced Plasmodium berghei infection in mice at a dose 640 mg/kg given as no. of toxic deaths ChEMBL. 3599024
Toxic deaths (ADMET) = 3 Suppressive blood schizonticidal antimalarial activity evaluated in the trophozoite-induced Plasmodium berghei infection in mice at a dose 40 mg/kg given as no. of toxic deaths ChEMBL. 3599024
Toxic deaths (functional) = 5 Suppressive blood schizonticidal antimalarial activity evaluated in the trophozoite-induced Plasmodium berghei infection in mice at a dose 160 mg/kg given as no. of toxic deaths ChEMBL. 3599024
Toxic deaths (ADMET) = 5 Suppressive blood schizonticidal antimalarial activity evaluated in the trophozoite-induced Plasmodium berghei infection in mice at a dose 640 mg/kg given as no. of toxic deaths ChEMBL. 3599024

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.