Detailed information for compound 337925

Basic information

Technical information
  • TDR Targets ID: 337925
  • Name: 4-[(1-phenylsulfanylnaphthalen-2-yl)methyl]-5 -piperidin-4-yl-1,2-oxazol-3-one
  • MW: 416.535 | Formula: C25H24N2O2S
  • H donors: 2 H acceptors: 2 LogP: 5.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1noc(c1Cc1ccc2c(c1Sc1ccccc1)cccc2)C1CCNCC1
  • InChi: 1S/C25H24N2O2S/c28-25-22(23(29-27-25)18-12-14-26-15-13-18)16-19-11-10-17-6-4-5-9-21(17)24(19)30-20-7-2-1-3-8-20/h1-11,18,26H,12-16H2,(H,27,28)
  • InChiKey: UCIQWRVUTVCZBG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(1-phenylsulfanyl-2-naphthyl)methyl]-5-(4-piperidyl)isoxazol-3-one
  • 4-[[1-(phenylthio)-2-naphthyl]methyl]-5-(4-piperidinyl)-3-isoxazolone
  • 4-[[1-(phenylthio)-2-naphthyl]methyl]-5-(4-piperidyl)-4-isoxazolin-3-one
  • 4-[[1-(phenylthio)-2-naphthyl]methyl]-5-(4-piperidyl)isoxazol-3-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus GABA-A receptor; anion channel Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Large subunit GTPase 1 homolog GABA-A receptor; anion channel   467 aa 496 aa 26.0 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog GABA-A receptor; anion channel   467 aa 418 aa 19.6 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 468 aa 28.6 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 434 aa 26.7 %
Echinococcus multilocularis glycine receptor subunit beta GABA-A receptor; anion channel   467 aa 478 aa 28.7 %
Brugia malayi Cation transporter family protein GABA-A receptor; anion channel   467 aa 453 aa 28.5 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 454 aa 30.4 %
Echinococcus granulosus glycine receptor subunit alpha 1 GABA-A receptor; anion channel   467 aa 430 aa 32.3 %
Onchocerca volvulus Gamma-aminobutyric acid receptor subunit beta homolog GABA-A receptor; anion channel   467 aa 433 aa 34.6 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 435 aa 29.7 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein GABA-A receptor; anion channel   467 aa 454 aa 29.5 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein GABA-A receptor; anion channel   467 aa 375 aa 21.9 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative GABA-A receptor; anion channel   467 aa 384 aa 19.5 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 446 aa 29.1 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 494 aa 25.5 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit GABA-A receptor; anion channel   467 aa 379 aa 19.3 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 447 aa 25.7 %
Echinococcus granulosus glycine receptor subunit beta GABA-A receptor; anion channel   467 aa 439 aa 29.6 %
Schistosoma mansoni Cys-loop ligand gated ion channel subunit GABA-A receptor; anion channel   467 aa 479 aa 29.2 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 441 aa 33.8 %
Onchocerca volvulus Eukaryotic initiation factor 4A-III homolog GABA-A receptor; anion channel   467 aa 453 aa 26.9 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 446 aa 28.0 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 461 aa 27.8 %
Echinococcus multilocularis glycine receptor subunit alpha 1 GABA-A receptor; anion channel   467 aa 430 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0037 0.0096 0.0439
Brugia malayi Cation transporter family protein 0.0023 0.0036 0.0053
Brugia malayi Tubulin alpha chain 0.1171 0.4862 0.7469
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0004 0.0004
Brugia malayi sulfakinin receptor protein 0.0225 0.0886 0.1359
Schistosoma mansoni ferritin 0.0018 0.0016 0.0021
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0004 0.0003
Brugia malayi photoreceptor-specific nuclear receptor 0.011 0.0403 0.0616
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0543 0.0832
Trypanosoma brucei cytochrome P450, putative 0.0026 0.005 0.0071
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.004 0.0192
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.0823 0.1262
Loa Loa (eye worm) hypothetical protein 0.0478 0.1952 0.2997
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0217 0.0327
Schistosoma mansoni tubulin subunit alpha 0.1171 0.4862 0.7468
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0136
Echinococcus granulosus integrin alpha ps 0.0068 0.0228 0.0344
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0028 0.0036
Trypanosoma brucei beta tubulin 0.1563 0.6509 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.055 0.0838
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0863 0.3567 0.5478
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.018 0.0273
Mycobacterium leprae cell division protein FtsZ 0.0396 0.1605 1
Mycobacterium leprae Probable lipase LipE 0.0145 0.055 0.3356
Loa Loa (eye worm) hypothetical protein 0.0775 0.3198 0.4912
Schistosoma mansoni lamin 0.0027 0.0054 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0091 0.0133
Loa Loa (eye worm) steroid hormone receptor 0.011 0.0403 0.0616
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0023 0.0036 0.0053
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0072 0.0246 0.1478
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0061 0.0079
Trichomonas vaginalis tubulin gamma chain, putative 0.0396 0.1605 0.2461
Onchocerca volvulus Protein patched homolog 0.0037 0.0096 0.0439
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0118 0.0178
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0242
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0091 0.0133
Onchocerca volvulus Putative organic anion transporter 0.0055 0.0174 0.084
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0242
Brugia malayi ecdysteroid receptor 0.011 0.0403 0.0616
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0143 0.0217
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1014 0.1552
Echinococcus granulosus bloom syndrome protein 0.0041 0.0113 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0252 0.1 0.1533
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0067 0.0097
Schistosoma mansoni agrin 0.0038 0.01 0.0151
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0023 0.0036 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0081 0.0118
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0139 0.021
Echinococcus multilocularis FTZ F1 alpha 0.011 0.0403 0.0399
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0054 0.008
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0118 0.0175
Loa Loa (eye worm) BEN-1 protein 0.1563 0.6509 1
Toxoplasma gondii patched family protein 0.0037 0.0096 0.0145
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.01 0.0152
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0036 0.0053
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0061 0.009
Giardia lamblia Alpha-tubulin 0.1171 0.4862 0.7465
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.011 0.0403 0.0399
Echinococcus granulosus tubulin alpha chain 0.1171 0.4862 0.7468
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0004 0.0004
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.0011
Brugia malayi MH2 domain containing protein 0.0024 0.0043 0.0063
Loa Loa (eye worm) TK protein kinase 0.0035 0.009 0.0136
Echinococcus multilocularis integrin alpha ps 0.0068 0.0228 0.0224
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0059
Echinococcus multilocularis integrin alpha ps 0.0033 0.0079 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0054 0.0076
Schistosoma mansoni hypothetical protein 0.016 0.0616 0.0943
Echinococcus multilocularis protein patched 0.0261 0.1039 0.1035
Toxoplasma gondii beta-1 tubulin, putative 0.1563 0.6509 1
Echinococcus granulosus Niemann Pick C1 protein 0.087 0.3598 0.5524
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0145 0.055 0.0842
Brugia malayi orphan nuclear receptor NR2E1 0.0052 0.0159 0.0242
Schistosoma mansoni tubulin subunit alpha 0.0396 0.1605 0.2464
Schistosoma mansoni tubulin subunit beta 0.1563 0.6509 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0081 0.0118
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0023 0.0036 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0129 0.0192
Loa Loa (eye worm) tubulin alpha-2 chain 0.1171 0.4862 0.7469
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0645 0.0985
Entamoeba histolytica protein kinase, putative 0.0035 0.009 0.0138
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0024 0.0044 0.0166
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0242
Trypanosoma brucei alpha tubulin, putative 0.0476 0.1941 0.2977
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0024 0.0044 0.0052
Mycobacterium tuberculosis Conserved protein 0.0145 0.055 0.1414
Brugia malayi CHE-14 protein 0.0261 0.1039 0.1594
Mycobacterium ulcerans beta-lactamase 0.0145 0.055 0.3383
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0242
Trichomonas vaginalis tubulin, putative 0.1563 0.6509 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0049 0.0146 0.0218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0208 0.0313
Echinococcus granulosus glycine receptor subunit beta 0.0023 0.0036 0.0049
Schistosoma mansoni integrin alpha-ps 0.0035 0.0091 0.0136
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.001 0.0008
Leishmania major alpha tubulin 0.1171 0.4862 0.7468
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0111 0.0408 0.0403
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0049 0.0146 0.0142
Loa Loa (eye worm) hypothetical protein 0.0055 0.0174 0.0265
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0052 0.0159 0.0241
Loa Loa (eye worm) RecQ helicase 0.0041 0.0113 0.0172
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0181 0.1074
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0096 0.0144
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Onchocerca volvulus 0.0048 0.0143 0.0678
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0118 0.0175
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0072 0.0246 0.1478
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.0174 0.0265
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0059 0.0055
Echinococcus multilocularis tyrosine protein kinase Srms 0.0042 0.0118 0.0114
Echinococcus granulosus cathepsin l1 0.0017 0.0011 0.0011
Echinococcus multilocularis GPCR, family 2 0.0066 0.022 0.0216
Echinococcus granulosus tyrosine protein kinase Src64B 0.0049 0.0146 0.0218
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0101 0.0097
Trichomonas vaginalis tubulin beta chain, putative 0.0476 0.1941 0.2977
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0011 0.0011
Brugia malayi Bloom's syndrome protein homolog 0.0041 0.0113 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0081 0.0118
Echinococcus multilocularis expressed protein 0.0038 0.01 0.0096
Echinococcus multilocularis tubulin alpha 1C chain 0.1171 0.4862 0.486
Echinococcus multilocularis tubulin epsilon chain 0.0924 0.3825 0.3823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0043 0.0059
Schistosoma mansoni tyrosine kinase 0.0104 0.038 0.0581
Leishmania major beta tubulin 0.1563 0.6509 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0072 0.0246 0.0377
Mycobacterium tuberculosis Probable reductase 0.0107 0.0392 0.1002
Echinococcus multilocularis epidermal growth factor receptor 0.0467 0.1903 0.1899
Loa Loa (eye worm) hypothetical protein 0.0026 0.0052 0.0077
Onchocerca volvulus 0.0476 0.1941 0.994
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0261 0.1039 0.1591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0208 0.0313
Onchocerca volvulus Putative organic anion transporter 0.0055 0.0174 0.084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Leishmania major beta tubulin 0.1563 0.6509 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0242
Echinococcus multilocularis tyrosine protein kinase Abl 0.0098 0.0354 0.035
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0111 0.0408 0.062
Onchocerca volvulus 0.0037 0.0096 0.0439
Trypanosoma brucei alpha tubulin 0.1171 0.4862 0.7468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0011
Brugia malayi Kelch motif family protein 0.0047 0.014 0.0213
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0021 0.0029 0.0025
Schistosoma mansoni nuclear hormone receptor 0.011 0.0403 0.0615
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0139 0.0207
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.01 0.0151
Echinococcus multilocularis nuclear receptor nhr 48 0.0052 0.0159 0.0155
Trichomonas vaginalis glutaminase, putative 0.029 0.116 0.1777
Loa Loa (eye worm) hypothetical protein 0.032 0.1286 0.1974
Schistosoma mansoni hypothetical protein 0.0252 0.1 0.1533
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0055 0.0174 0.017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0241 0.0364
Echinococcus multilocularis tubulin delta chain 0.0396 0.1605 0.1602
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0139 0.0135
Echinococcus granulosus integrin beta 2 0.0231 0.0911 0.1394
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0044 0.006
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0146 0.0142
Brugia malayi Steroid receptor seven-up type 2 0.011 0.0403 0.0616
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0044 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.055 0.0841
Toxoplasma gondii beta-tubulin, putative 0.1563 0.6509 1
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0055 0.0174 0.0265
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0092 0.0138
Loa Loa (eye worm) nuclear receptor NHR-67 0.0052 0.0159 0.0242
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0241 0.0367
Brugia malayi hypothetical protein 0.0047 0.014 0.0213
Trichomonas vaginalis tubulin epsilon chain, putative 0.1171 0.4862 0.7468
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0016 0.004
Echinococcus multilocularis L aminoadipate semialdehyde 0.0257 0.1024 0.102
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.011 0.0403 0.0616
Loa Loa (eye worm) tubulin beta-1 chain 0.1563 0.6509 1
Brugia malayi prostaglandin transporter 0.0055 0.0174 0.0265
Leishmania major beta tubulin 0.1563 0.6509 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0042 0.006
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.018 0.027
Trypanosoma cruzi MFS transporter, putative 0.0055 0.0174 0.0264
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0015
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0015
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0036 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0081 0.0118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Treponema pallidum NADH oxidase 0.0016 0.001 0.0047
Echinococcus multilocularis tyrosine protein kinase HCK 0.0035 0.009 0.0086
Loa Loa (eye worm) hypothetical protein 0.0085 0.0298 0.0455
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0023 0.0036 0.0052
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0208 0.0316
Echinococcus granulosus neuropeptide s receptor 0.0471 0.1922 0.2948
Echinococcus multilocularis peroxisome assembly protein 26 0.1171 0.4862 0.486
Schistosoma mansoni hypothetical protein 0.0066 0.022 0.0335
Toxoplasma gondii protease inhibitor PI2 0.0038 0.01 0.0151
Echinococcus granulosus fibroblast growth factor receptor 4 0.0104 0.038 0.0578
Trypanosoma cruzi beta tubulin, putative 0.1563 0.6509 1
Schistosoma mansoni cpg binding protein 0.0091 0.0322 0.0491
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0036 0.0049
Schistosoma mansoni integrin alpha-ps 0.0068 0.0228 0.0347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.011 0.0403 0.0616
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0021
Echinococcus granulosus ferritin 0.0018 0.0016 0.0018
Brugia malayi hypothetical protein 0.0037 0.0096 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0081 0.0118
Brugia malayi conserved hypotetical protein 0.0052 0.0159 0.0242
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0092 0.0514
Loa Loa (eye worm) hypothetical protein 0.0055 0.0174 0.0265
Brugia malayi hypothetical protein 0.0071 0.0241 0.0368
Entamoeba histolytica hypothetical protein 0.0071 0.0241 0.037
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.004 0.0192
Loa Loa (eye worm) tubulin beta-4 chain 0.1563 0.6509 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.011 0.0403 0.0616
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0028 0.0036
Brugia malayi nuclear receptor NHR-88 0.0052 0.0159 0.0242
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0061 0.0091
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0044 0.006
Giardia lamblia Epsilon tubulin 0.0448 0.1826 0.2794
Schistosoma mansoni nuclear receptor 0.0052 0.0159 0.0241
Schistosoma mansoni hypothetical protein 0.0252 0.1 0.1533
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0011
Brugia malayi hypothetical protein 0.0058 0.0185 0.0282
Echinococcus multilocularis ecdysone induced protein 78C 0.011 0.0403 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0052 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0208 0.0313
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0443 0.1133
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0111 0.0408 0.0403
Toxoplasma gondii cathepsin CPL 0.0017 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Brugia malayi beta-lactamase family protein 0.0145 0.055 0.0842
Echinococcus granulosus tubulin alpha chain 0.1171 0.4862 0.7468
Echinococcus granulosus Tubulin alpha 1 chain 0.1171 0.4862 0.7468
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.011 0.0403 0.0616
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0044 0.006
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0023 0.0036 0.0052
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.022 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0081 0.0118
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0079 0.0275 0.0416
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0072 0.011
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0111 0.0408 0.0612
Plasmodium vivax tubulin gamma chain, putative 0.0925 0.3829 0.5882
Trichomonas vaginalis tubulin, putative 0.0476 0.1941 0.2977
Onchocerca volvulus 0.0037 0.0096 0.0439
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0645 0.0985
Echinococcus multilocularis sterol regulatory element binding protein 0.0261 0.1039 0.1035
Echinococcus granulosus tyrosine protein kinase Src42A 0.0049 0.0146 0.0218
Plasmodium vivax hypothetical protein, conserved 0.0145 0.055 0.0844
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0217 0.0334
Brugia malayi hypothetical protein 0.0037 0.0096 0.0146
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0036 0.0032
Loa Loa (eye worm) tubulin alpha chain 0.1171 0.4862 0.7469
Loa Loa (eye worm) hypothetical protein 0.0047 0.014 0.0213
Schistosoma mansoni Tr4/Tr2 (homologue) 0.011 0.0403 0.0615
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.018 0.027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0208 0.0313
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.018 0.027
Schistosoma mansoni tyrosine kinase 0.002 0.0024 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0028 0.0036
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0049 0.0146 0.0142
Echinococcus multilocularis tubulin alpha chain 0.1171 0.4862 0.486
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0145 0.055 0.0842
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0023 0.0036 0.0053
Toxoplasma gondii patched family protein 0.0037 0.0096 0.0145
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.004 0.0152
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.006
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0044 0.0067
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0118 0.0175
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0139 0.0214
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.002 0.0024 0.0034
Giardia lamblia Delta tubulin 0.0396 0.1605 0.2455
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0061 0.0087
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0043 0.0038
Echinococcus granulosus tubulin epsilon chain 0.0924 0.3825 0.5874
Leishmania major beta tubulin 0.1563 0.6509 1
Schistosoma mansoni tubulin subunit beta 0.1563 0.6509 1
Echinococcus granulosus beta tubulin 0.1563 0.6509 1
Echinococcus multilocularis cysteine protease 0.0017 0.0011 0.0007
Onchocerca volvulus 0.0052 0.0159 0.0761
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1563 0.6509 0.6508
Loa Loa (eye worm) DR-78 0.0052 0.0159 0.0242
Echinococcus granulosus dnaJ subfamily B 0.0863 0.3567 0.5476
Trypanosoma brucei zeta tubulin, putative 0.0946 0.3916 0.6014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.011 0.0403 0.0615
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.006
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0091 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0645 0.0985
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0042
Loa Loa (eye worm) tubulin beta-2A chain 0.1563 0.6509 1
Echinococcus multilocularis insulin receptor 0.0152 0.0579 0.0575
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.001 0.0015
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.022 0.0216
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Loa Loa (eye worm) TK protein kinase 0.0107 0.0393 0.0601
Echinococcus granulosus tyrosine kinase 0.0042 0.0118 0.0175
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.001 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.011 0.0403 0.0616
Brugia malayi excitatory GABA receptor EXP-1A 0.0023 0.0036 0.0053
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0392 0.1002
Schistosoma mansoni glutaminase 0.029 0.116 0.1779
Echinococcus multilocularis expressed conserved protein 0.0572 0.2345 0.2341
Brugia malayi Cation transporter family protein 0.0023 0.0036 0.0053
Echinococcus granulosus FTZ F1 alpha 0.011 0.0403 0.0613
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0111 0.0408 0.0403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0208 0.0313
Brugia malayi Nuclear hormone receptor E75 0.0052 0.0159 0.0242
Mycobacterium ulcerans cell division protein FtsZ 0.0396 0.1605 1
Echinococcus granulosus tubulin alpha chain 0.1171 0.4862 0.7468
Trichomonas vaginalis conserved hypothetical protein 0.0396 0.1605 0.2461
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0181 0.1074
Mycobacterium tuberculosis Probable lipase LipD 0.0145 0.055 0.1414
Loa Loa (eye worm) hypothetical protein 0.0162 0.0624 0.0956
Schistosoma mansoni tubulin subunit gamma 0.0925 0.3829 0.588
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0072 0.0246 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0061
Schistosoma mansoni integrin alpha 0.0152 0.0581 0.0889
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.0403 0.0616
Entamoeba histolytica hypothetical protein 0.0071 0.0241 0.037
Trypanosoma brucei epsilon tubulin 0.0924 0.3825 0.5874
Schistosoma mansoni hypothetical protein 0.0066 0.022 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0096 0.0141
Echinococcus granulosus nAChR subunit 0.0023 0.0036 0.0049
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0004 0.0003
Onchocerca volvulus 0.0027 0.0054 0.022
Loa Loa (eye worm) ctsf protein 0.0017 0.0011 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1014 0.1552
Echinococcus multilocularis neuropeptide s receptor 0.0471 0.1922 0.1918
Echinococcus multilocularis Niemann Pick C1 protein 0.087 0.3598 0.3595
Echinococcus granulosus tubulin alpha 3 chain 0.1171 0.4862 0.7468
Leishmania major beta tubulin 0.1563 0.6509 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.004 0.0059
Echinococcus multilocularis tubulin alpha chain 0.1171 0.4862 0.486
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0066 0.022 0.0336
Trichomonas vaginalis tubulin alpha chain, putative 0.0476 0.1941 0.2977
Echinococcus granulosus integrin alpha 3 0.0117 0.0431 0.0656
Echinococcus multilocularis neuroglian 0.0024 0.0041 0.0037
Brugia malayi hypoxia-induced factor 1 0.015 0.0571 0.0874
Onchocerca volvulus 0.0023 0.0036 0.0128
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0242
Loa Loa (eye worm) TK/KIN16 protein kinase 0.003 0.0068 0.0103
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Entamoeba histolytica tubulin gamma chain 0.0925 0.3829 0.5882
Loa Loa (eye worm) hypothetical protein 0.1171 0.4862 0.7469
Entamoeba histolytica hypothetical protein 0.0071 0.0241 0.037
Echinococcus granulosus twitchin 0.0024 0.0043 0.006
Loa Loa (eye worm) tubulin alpha 2 0.0775 0.3198 0.4912
Leishmania major zeta tubulin, putative 0.0946 0.3916 0.6014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Schistosoma mansoni tubulin subunit epsilon 0.0924 0.3825 0.5875
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0011
Echinococcus granulosus eukaryotic initiation factor 4A 0.0024 0.0044 0.006
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.004 0.0056
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0015
Brugia malayi Tubulin alpha-2 chain 0.1171 0.4862 0.7469
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0218 0.0859 0.0855
Trypanosoma brucei protein kinase, putative 0.0057 0.018 0.027
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0096 0.0092
Leishmania major delta tubulin, putative 0.0725 0.2988 0.4586
Echinococcus granulosus Tubulin beta 2C chain 0.1563 0.6509 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0104 0.0159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0208 0.0313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.011 0.0403 0.0616
Brugia malayi ecdysone receptor 0.0052 0.0159 0.0242
Brugia malayi SPARC precursor 0.0038 0.01 0.0152
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.004 0.0192
Leishmania major trypanothione reductase 0.0047 0.0139 0.0207
Leishmania major beta tubulin 0.1563 0.6509 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0468 0.0712
Echinococcus granulosus Protein patched homolog 1 0.0261 0.1039 0.1591
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0145 0.0219
Echinococcus granulosus tubulin beta 4A class IVa 0.1563 0.6509 1
Schistosoma mansoni apoferritin-2 0.0018 0.0016 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0012
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0023 0.0036 0.0053
Loa Loa (eye worm) hypothetical protein 0.0695 0.2863 0.4396
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0129 0.0125
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0058 0.0185 0.0282
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0011 0.0011
Trypanosoma brucei tubulin delta chain 0.0725 0.2988 0.4586
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0129 0.0192
Brugia malayi nuclear hormone receptor 0.0052 0.0159 0.0242
Echinococcus granulosus thyroid hormone receptor alpha 0.0052 0.0159 0.0238
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.055 0.0841
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1014 0.1552
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0096 0.0141
Leishmania major beta tubulin 0.1563 0.6509 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.011 0.0403 0.0616
Echinococcus granulosus nuclear receptor 2DBD gamma 0.011 0.0403 0.0613
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.0823 0.1262
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0008
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0072 0.0246 0.0374
Plasmodium vivax tubulin epsilon chain, putative 0.0924 0.3825 0.5877
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0072 0.0104
Echinococcus granulosus smad 0.0024 0.0043 0.0059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0332 0.0508
Mycobacterium ulcerans glutaminase 0.029 0.116 0.7209
Brugia malayi Tubulin beta chain 0.0476 0.1941 0.298
Echinococcus multilocularis roundabout 2 0.003 0.0066 0.0062
Echinococcus granulosus tyrosine protein kinase Blk 0.0042 0.0118 0.0175
Trichomonas vaginalis helicase, putative 0.0021 0.0028 0.0036
Echinococcus multilocularis dnaJ subfamily B 0.0863 0.3567 0.3564
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.004 0.0056
Brugia malayi isocitrate dehydrogenase 0.0111 0.0408 0.0624
Brugia malayi nuclear receptor RXR 0.0052 0.0159 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0028 0.0036
Onchocerca volvulus 0.0091 0.0322 0.1601
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Brugia malayi MH2 domain containing protein 0.0354 0.1428 0.2192
Plasmodium vivax RNA helicase-1, putative 0.0024 0.0044 0.0067
Toxoplasma gondii histone lysine methyltransferase SET1 0.0175 0.0677 0.1037
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0139 0.0211
Schistosoma mansoni coup transcription factor 0.011 0.0403 0.0615
Trichomonas vaginalis tubulin epsilon chain, putative 0.1563 0.6509 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Entamoeba histolytica hypothetical protein 0.0071 0.0241 0.037
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0146 0.0218
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0061 0.0091
Leishmania major alpha tubulin 0.1171 0.4862 0.7468
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0096 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0011
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0217 0.0331
Brugia malayi Tyrosine-protein kinase abl-1 0.0127 0.0474 0.0726
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0036 0.0053
Schistosoma mansoni alpha tubulin 0.1171 0.4862 0.7468
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0129 0.0198
Onchocerca volvulus 0.0023 0.0036 0.0128
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0145
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.018 0.0273
Echinococcus multilocularis bloom syndrome protein 0.0041 0.0113 0.0109
Trypanosoma cruzi alpha tubulin, putative 0.1171 0.4862 0.7468
Echinococcus multilocularis tubulin alpha 0.0872 0.3605 0.3602
Brugia malayi AMP-binding enzyme family protein 0.0024 0.004 0.0059
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0055 0.0174 0.017
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0217 0.033
Entamoeba histolytica tubulin alpha chain, putative 0.1171 0.4862 0.7469
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0129 0.0198
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.011 0.0403 0.0616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0011
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0392 0.1002
Trypanosoma cruzi zeta tubulin, putative 0.0946 0.3916 0.6015
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0165 0.0251
Echinococcus multilocularis epidermal growth factor receptor 0.0252 0.1002 0.0999
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.018 0.0262
Brugia malayi hypothetical protein 0.0478 0.1952 0.2997
Trichomonas vaginalis tubulin alpha chain, putative 0.1563 0.6509 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0467 0.1903 0.2921
Trichomonas vaginalis tubulin gamma chain, putative 0.0924 0.3825 0.5874
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0052 0.0077
Trypanosoma brucei trypanothione reductase 0.0047 0.0139 0.0207
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0217 0.033
Loa Loa (eye worm) fibroinase 0.0017 0.0011 0.0015
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0526 0.0803
Trypanosoma brucei beta tubulin 0.1563 0.6509 1
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.055 0.0838
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0396 0.1605 0.2461
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0129 0.0192
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0148 0.0224
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0024 0.0044 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0043 0.0059
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.018 0.027
Echinococcus granulosus neuroglian 0.0024 0.0041 0.0057
Leishmania major beta tubulin 0.1563 0.6509 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.022 0.0336
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Echinococcus multilocularis muscleblind protein 0.0166 0.0641 0.0637
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.001 0.0008
Schistosoma mansoni nAChR subunit 0.0023 0.0036 0.0052
Echinococcus granulosus tyrosine protein kinase ABL1 0.0218 0.0859 0.1314
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Trypanosoma brucei alpha tubulin 0.1171 0.4862 0.7468
Toxoplasma gondii patched family protein 0.0037 0.0096 0.0145
Plasmodium vivax tubulin beta chain, putative 0.1563 0.6509 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0028 0.0036
Loa Loa (eye worm) hypothetical protein 0.0038 0.01 0.0152
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0011 0.0007
Brugia malayi MAP kinase sur-1 0.0057 0.018 0.0274
Schistosoma mansoni tubulin subunit beta 0.1563 0.6509 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.01 0.0152
Echinococcus multilocularis glycine receptor subunit beta 0.0023 0.0036 0.0032
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0023 0.0036 0.0049
Schistosoma mansoni hypothetical protein 0.0033 0.0079 0.0117
Loa Loa (eye worm) hypothetical protein 0.0166 0.0641 0.0982
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0036 0.0053
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0645 0.0985
Echinococcus granulosus c src tyrosine kinase 0.002 0.0024 0.0031
Brugia malayi hypothetical protein 0.0225 0.0886 0.1359
Brugia malayi eukaryotic initiation factor 4A 0.0024 0.0044 0.0064
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.011 0.0403 0.0613
Echinococcus granulosus tubulin alpha chain 0.1171 0.4862 0.7468
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0015
Brugia malayi Cytochrome P450 family protein 0.0026 0.005 0.0075
Schistosoma mansoni tyrosine kinase 0.002 0.0024 0.0034
Loa Loa (eye worm) alpha-tubulin 0.1171 0.4862 0.7469
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0332 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0102 0.015
Plasmodium falciparum ataxin-2 like protein, putative 0.0177 0.0685 0.1039
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0054 0.008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0043 0.0059
Loa Loa (eye worm) hypothetical protein 0.011 0.0403 0.0616
Echinococcus multilocularis thyroid hormone receptor alpha 0.0235 0.0929 0.0925
Echinococcus multilocularis tubulin subunit TubB 0.1171 0.4862 0.486
Echinococcus multilocularis Tubulin beta 2C chain 0.1563 0.6509 0.6508
Loa Loa (eye worm) hypothetical protein 0.0145 0.055 0.0842
Brugia malayi Smad1 0.0024 0.0043 0.0063
Schistosoma mansoni alpha tubulin 0.1171 0.4862 0.7468
Plasmodium falciparum ataxin-2 like protein, putative 0.0177 0.0685 0.1039
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0396 0.1605 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0443 0.2682
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0261 0.1039 0.1594
Loa Loa (eye worm) hypothetical protein 0.0055 0.0174 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.011 0.0403 0.0616
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0047 0.014 0.0213
Echinococcus granulosus geminin 0.1378 0.5735 0.881
Onchocerca volvulus 0.0055 0.0174 0.084
Schistosoma mansoni nephrin 0.0027 0.0053 0.0078
Loa Loa (eye worm) hypothetical protein 0.0609 0.25 0.3839
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0011 0.0017
Echinococcus granulosus beta LACTamase domain containing family member 0.0145 0.055 0.0838
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0044 0.006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.001 0.0012
Trichomonas vaginalis ferritin, putative 0.0018 0.0016 0.0018
Brugia malayi Cation transporter family protein 0.0023 0.0036 0.0053
Loa Loa (eye worm) hypothetical protein 0.0261 0.1039 0.1594
Leishmania major hypothetical protein, conserved 0.0177 0.0685 0.1047
Loa Loa (eye worm) hypothetical protein 0.0027 0.0054 0.008
Brugia malayi alpha-tubulin 0.1171 0.4862 0.7469
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.001 0.0008
Onchocerca volvulus 0.0023 0.0036 0.0128
Loa Loa (eye worm) TK/INSR protein kinase 0.0152 0.0579 0.0887
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0061 0.009
Schistosoma mansoni tyrosine kinase 0.0152 0.0579 0.0886
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0145 0.055 0.1414
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.001 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0185 0.0282
Brugia malayi Patched related family protein 12 0.0037 0.0096 0.0146
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.018 0.0273
Leishmania major beta tubulin 0.1563 0.6509 1
Giardia lamblia Gamma tubulin 0.0925 0.3829 0.5876
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0104 0.0144
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0036 0.0049
Schistosoma mansoni nuclear receptor 0.0052 0.0159 0.0241
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.018 0.027
Onchocerca volvulus 0.0055 0.0174 0.084
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.0011
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0016 0.004
Schistosoma mansoni tyrosine kinase 0.0246 0.0975 0.1496
Mycobacterium ulcerans lipase LipD 0.0145 0.055 0.3383
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.018 0.0273
Echinococcus multilocularis tubulin beta 1 chain 0.1563 0.6509 0.6508
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0036 0.0053
Loa Loa (eye worm) hypothetical protein 0.0058 0.0185 0.0282
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0146 0.0218
Onchocerca volvulus Protein ultraspiracle homolog 0.011 0.0403 0.2017
Plasmodium vivax delta tubulin, putative 0.0396 0.1605 0.2466
Brugia malayi beta-tubulin, identical 0.1563 0.6509 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0011
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0049 0.0146 0.0142
Mycobacterium tuberculosis Conserved protein 0.0145 0.055 0.1414
Echinococcus multilocularis neuropeptide receptor A26 0.0471 0.1922 0.1918
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0028 0.0036
Brugia malayi nuclear receptor NHR-88 0.011 0.0403 0.0616
Brugia malayi protein C24B5.3 0.0037 0.0096 0.0146
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Loa Loa (eye worm) hypothetical protein 0.0235 0.093 0.1426
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0027
Toxoplasma gondii isocitrate dehydrogenase 0.0111 0.0408 0.0623
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.011 0.0403 0.0399
Trichomonas vaginalis tubulin beta chain, putative 0.1171 0.4862 0.7468
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0011 0.0004
Echinococcus multilocularis Tubulin beta 2C chain 0.1563 0.6509 0.6508
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0645 0.0985
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0242
Echinococcus granulosus tubulin alpha 3 chain 0.1171 0.4862 0.7468
Plasmodium falciparum tubulin gamma chain 0.0925 0.3829 0.5876
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0645 0.0985
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.011 0.0403 0.0399
Echinococcus granulosus tubulin alpha 1C chain 0.1171 0.4862 0.7468
Schistosoma mansoni RAR-like nuclear receptor 0.011 0.0403 0.0615
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0011 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.001 0.0008
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0096 0.0141
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Echinococcus granulosus defective proboscis extension response 0.0021 0.0029 0.0038
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0392 0.1002
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0072 0.0246 0.0618
Echinococcus multilocularis tubulin alpha 3 chain 0.1171 0.4862 0.486
Echinococcus granulosus tubulin subunit TubB 0.1171 0.4862 0.7468
Loa Loa (eye worm) glutaminase 0.029 0.116 0.178
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0129 0.0196
Echinococcus granulosus expressed conserved protein 0.0572 0.2345 0.3598
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0028 0.0036
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.018 0.027
Trichomonas vaginalis tubulin alpha chain, putative 0.0872 0.3605 0.5535
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.004 0.0062
Loa Loa (eye worm) MH2 domain-containing protein 0.0354 0.1428 0.2192
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0023 0.0036 0.0032
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Loa Loa (eye worm) TK/ABL protein kinase 0.0218 0.0859 0.1317
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.011 0.0403 0.0613
Echinococcus multilocularis integrin alpha 3 0.0117 0.0431 0.0427
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0104 0.038 0.0376
Onchocerca volvulus 0.0037 0.0096 0.0439
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.005 0.0074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.022 0.0336
Echinococcus multilocularis expressed protein 0.0018 0.0016 0.0012
Mycobacterium ulcerans hypothetical protein 0.0145 0.055 0.3383
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.001 0.0012
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0151 0.0228
Onchocerca volvulus 0.0037 0.0096 0.0439
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0242
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0129 0.0192
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.018 0.0273
Echinococcus multilocularis beta LACTamase domain containing family member 0.0145 0.055 0.0545
Brugia malayi MH2 domain containing protein 0.0024 0.0043 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0028 0.0036
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.004 0.008
Loa Loa (eye worm) patched family protein 0.0037 0.0096 0.0146
Onchocerca volvulus 0.0024 0.004 0.015
Trichomonas vaginalis DNA helicase recq1, putative 0.0041 0.0113 0.0168
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0155 0.0591 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0011
Brugia malayi CXXC zinc finger family protein 0.0091 0.0322 0.0492
Brugia malayi Cell division protein ftsZ 0.0396 0.1605 0.2464
Trichomonas vaginalis tubulin, putative 0.0476 0.1941 0.2977
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0028 0.0036
Schistosoma mansoni apoferritin-2 0.0018 0.0016 0.0021
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0011 0.0014
Schistosoma mansoni lamin 0.0027 0.0054 0.008
Schistosoma mansoni hypothetical protein 0.0079 0.0275 0.0419
Echinococcus granulosus tubulin subunit beta 0.1563 0.6509 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0021
Brugia malayi Thioredoxin reductase 0.0047 0.0139 0.0211
Echinococcus multilocularis smad 0.0024 0.0043 0.0038
Loa Loa (eye worm) patched family protein 0.0037 0.0096 0.0146
Echinococcus multilocularis tumor protein p63 0.0336 0.1354 0.135
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0036 0.0032
Echinococcus granulosus tyrosine protein kinase HCK 0.0035 0.009 0.0132
Onchocerca volvulus 0.0023 0.0036 0.0128
Echinococcus multilocularis lamin dm0 0.0027 0.0054 0.005
Onchocerca volvulus 0.0049 0.0148 0.0705
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.001 0.0015
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0159 0.0241
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0129 0.0195
Plasmodium falciparum glutathione reductase 0.0047 0.0139 0.0199
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0024 0.0044 0.0063
Loa Loa (eye worm) patched family protein 0.0037 0.0096 0.0146
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0208 0.0316
Loa Loa (eye worm) hypoxia-induced factor 1 0.015 0.0571 0.0874
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.0174 0.0265
Leishmania major alpha tubulin 0.1171 0.4862 0.7468
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.004 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-49 0.011 0.0403 0.0616
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0145 0.055 0.3383
Loa Loa (eye worm) transcription factor SMAD2 0.0354 0.1428 0.2192
Echinococcus granulosus lamin 0.0027 0.0054 0.0076
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.0544 0.0833
Echinococcus granulosus tubulin gamma 1 chain 0.0925 0.3829 0.5879
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Trypanosoma cruzi PAB1-binding protein , putative 0.0177 0.0685 0.1049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0208 0.0313
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0049 0.0146 0.0142
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.055 0.0841
Onchocerca volvulus 0.0037 0.0096 0.0439
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0129 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0011
Leishmania major beta tubulin 0.1563 0.6509 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0185 0.0282
Plasmodium falciparum alpha tubulin 2 0.1171 0.4862 0.7465
Leishmania major beta tubulin 0.1563 0.6509 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0004 0.0003
Schistosoma mansoni organic anion transporter 0.0055 0.0174 0.0264
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0096 0.0144
Mycobacterium tuberculosis Conserved protein 0.0145 0.055 0.1414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0043 0.0059
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0052 0.0159 0.0238
Echinococcus multilocularis Tubulin alpha 1 chain 0.1171 0.4862 0.486
Loa Loa (eye worm) hypothetical protein 0.021 0.0823 0.1262
Onchocerca volvulus Putative nachr subunit 0.0023 0.0036 0.0128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0011
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0015
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Leishmania major alpha tubulin 0.1171 0.4862 0.7468
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0011
Brugia malayi hypothetical protein 0.0052 0.0159 0.0242
Echinococcus multilocularis Tubulin beta 2C chain 0.1563 0.6509 0.6508
Loa Loa (eye worm) nuclear hormone receptor 0.0052 0.0159 0.0242
Plasmodium falciparum tubulin beta chain 0.1563 0.6509 1
Loa Loa (eye worm) patched family protein 0.0037 0.0096 0.0146
Brugia malayi Tubulin gamma chain 0.0925 0.3829 0.5881
Brugia malayi MH1 domain containing protein 0.0024 0.0043 0.0063
Schistosoma mansoni tyrosine kinase 0.0049 0.0146 0.0221
Trypanosoma brucei beta tubulin 0.1563 0.6509 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0925 0.3829 0.5879
Loa Loa (eye worm) hypothetical protein 0.0049 0.0148 0.0225
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.055 0.0838
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0015 0.0024
Echinococcus granulosus sterol regulatory element binding protein 0.0261 0.1039 0.1591
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0061 0.0057
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0058 0.0185 0.0282
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.004 0.0062
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0061 0.0057
Schistosoma mansoni tyrosine kinase 0.0212 0.083 0.1273
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0181 0.0177
Echinococcus multilocularis integrin beta 2 0.0231 0.0911 0.0907
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0217 0.0331
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0011 0.0015
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0011 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0036 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0683 0.1043
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0096 0.0141
Echinococcus granulosus nuclear receptor nhr 48 0.0052 0.0159 0.0238
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0036 0.0053
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Schistosoma mansoni tubulin subunit beta 0.1563 0.6509 1
Brugia malayi hypothetical protein 0.0162 0.0624 0.0956
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.004 0.0056
Loa Loa (eye worm) CYP4Cod1 0.0026 0.005 0.0075
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.055 0.0838
Echinococcus multilocularis integrin alpha ps 0.0068 0.0228 0.0224
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0011 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0235 0.0929 0.1424
Echinococcus multilocularis Smad4 0.0024 0.0043 0.0038
Brugia malayi protein-tyrosine kinase 0.0042 0.0118 0.0179
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0011 0.0014
Plasmodium vivax vivapain-2 0.0017 0.0011 0.0017
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Toxoplasma gondii alpha tubulin TUBA1 0.1171 0.4862 0.7468
Echinococcus granulosus epidermal growth factor receptor 0.0252 0.1002 0.1534
Echinococcus granulosus agrin 0.0038 0.01 0.0148
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.005 0.0075
Echinococcus multilocularis protein dispatched 1 0.0298 0.1194 0.1191
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0725 0.2988 0.4588
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Leishmania major beta tubulin 0.1563 0.6509 1
Plasmodium vivax vivapain-2 0.0017 0.0011 0.0017
Echinococcus multilocularis tubulin alpha chain 0.1171 0.4862 0.486
Onchocerca volvulus 0.0036 0.0092 0.0415
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0036 0.0053
Toxoplasma gondii tubulin, putative 0.0052 0.0162 0.0245
Leishmania major beta tubulin 0.1563 0.6509 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0181 0.0449
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0609 0.25 0.384
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0241 0.0237
Echinococcus multilocularis cysteine protease 0.0017 0.0011 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.0823 0.1262
Onchocerca volvulus 0.0023 0.0036 0.0128
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.055 0.0841
Schistosoma mansoni tubulin subunit alpha 0.1171 0.4862 0.7468
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0015 0.0035
Schistosoma mansoni nAChR subunit 0.0023 0.0036 0.0052
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0058 0.0185 0.0281
Plasmodium falciparum tubulin delta chain, putative 0.0396 0.1605 0.2455
Trichomonas vaginalis tubulin alpha chain, putative 0.0476 0.1941 0.2977
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0104 0.0144
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1014 0.1552
Loa Loa (eye worm) tubulin beta chain 0.1563 0.6509 1
Leishmania major alpha tubulin 0.1171 0.4862 0.7468
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.018 0.0176
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0019 0.0023
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0217 0.033
Leishmania major phosphopantetheinyl transferase-like protein 0.0072 0.0246 0.0371
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0016 0.004
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Echinococcus multilocularis 0.0143 0.0543 0.0539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0043 0.0059
Loa Loa (eye worm) hypothetical protein 0.011 0.0403 0.0616
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0055 0.0174 0.0261
Trichomonas vaginalis tubulin beta chain, putative 0.1171 0.4862 0.7468
Echinococcus granulosus nuclear receptor 2DBD gamma 0.011 0.0403 0.0613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0011
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0058 0.0185 0.0278
Loa Loa (eye worm) LGC-31 protein 0.0023 0.0036 0.0053
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0061 0.0079
Trypanosoma brucei epsilon tubulin 0.0924 0.3825 0.5874
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.001 0.0012
Leishmania major beta tubulin 0.1563 0.6509 1
Mycobacterium tuberculosis Probable lipase LipE 0.0145 0.055 0.1414
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0096 0.0144
Echinococcus multilocularis tubulin alpha chain 0.1171 0.4862 0.486
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0038 0.01 0.0152
Giardia lamblia Beta tubulin 0.1563 0.6509 1
Toxoplasma gondii transporter, major facilitator family protein 0.0055 0.0174 0.0264
Echinococcus multilocularis lamin 0.0027 0.0054 0.005
Onchocerca volvulus 0.0145 0.055 0.2773
Schistosoma mansoni nAChR subunit 0.0023 0.0036 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0332 0.0507
Brugia malayi Tubulin alpha-2 chain 0.1171 0.4862 0.7469
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0028 0.0036
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0021 0.0029 0.0041
Brugia malayi beta-lactamase 0.0145 0.055 0.0842
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Brugia malayi steroid hormone receptor 0.011 0.0403 0.0616
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0023 0.0036 0.0053
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0118 0.0178
Schistosoma mansoni tyrosine kinase 0.0152 0.0579 0.0886
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.1014 0.1555
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0145 0.055 0.1414
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0043 0.0063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0011 0.0004
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.0011
Echinococcus multilocularis geminin 0.1378 0.5735 0.5733
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.1014 0.1555
Schistosoma mansoni ferritin 0.0018 0.0016 0.0021
Echinococcus granulosus Immunoglobulin 0.0021 0.0029 0.0038
Plasmodium vivax patched family protein, putative 0.0037 0.0096 0.0148
Echinococcus granulosus Tubulin beta 2C chain 0.1563 0.6509 1
Echinococcus granulosus Tubulin alpha 1 chain 0.1171 0.4862 0.7468
Leishmania major alpha tubulin 0.1171 0.4862 0.7468
Echinococcus granulosus insulin receptor 0.0152 0.0579 0.0883
Brugia malayi Tubulin alpha chain 0.0396 0.1605 0.2464
Brugia malayi hypothetical protein 0.0037 0.0096 0.0146
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.004 0.0192
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Schistosoma mansoni cpg binding protein 0.0096 0.0344 0.0525
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0091 0.0133
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0072 0.0246 0.1518
Schistosoma mansoni tyrosine kinase 0.0467 0.1903 0.292
Brugia malayi Immunoglobulin I-set domain containing protein 0.0107 0.0393 0.0601
Echinococcus multilocularis beta tubulin 0.1563 0.6509 0.6508
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0332 0.0504
Leishmania major alpha tubulin 0.1171 0.4862 0.7468
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0146 0.0218
Schistosoma mansoni nAChR subunit 0.0023 0.0036 0.0052
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0443 0.1133
Schistosoma mansoni ferritin light chain 0.0018 0.0016 0.0021
Brugia malayi hypothetical protein 0.0055 0.0174 0.0265
Schistosoma mansoni hypothetical protein 0.0252 0.1 0.1533
Brugia malayi hypothetical protein 0.0055 0.0174 0.0265
Brugia malayi Patched related family protein 10 0.0037 0.0096 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0091 0.0133
Onchocerca volvulus Bile acid receptor homolog 0.011 0.0403 0.2017
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0044 0.0063
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0052 0.0159 0.0155
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0059 0.0088
Plasmodium falciparum eukaryotic initiation factor 4A 0.0024 0.0044 0.0052
Schistosoma mansoni smad1 5 8 and 0.0024 0.0043 0.0062
Toxoplasma gondii beta tubulin 0.1563 0.6509 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0043 0.0059
Onchocerca volvulus 0.0023 0.0036 0.0128
Echinococcus granulosus peroxisome assembly protein 26 0.1171 0.4862 0.7468
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0146 0.0142
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0111 0.0408 0.0626
Trichomonas vaginalis tubulin gamma chain, putative 0.1563 0.6509 1
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.055 0.0838
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0011
Trichomonas vaginalis tubulin, putative 0.0449 0.1829 0.2805
Loa Loa (eye worm) hypothetical protein 0.0027 0.0054 0.008
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0096 0.0141
Trichomonas vaginalis tubulin beta chain, putative 0.1171 0.4862 0.7468
Trypanosoma cruzi zeta tubulin, putative 0.0946 0.3916 0.6015
Brugia malayi Isocitrate dehydrogenase 0.0111 0.0408 0.0624
Giardia lamblia Beta tubulin 0.1563 0.6509 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0015 0.0015
Onchocerca volvulus 0.0257 0.1024 0.5215
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0145 0.055 0.0842
Loa Loa (eye worm) SRC-1 0.0049 0.0146 0.0222
Loa Loa (eye worm) hypothetical protein 0.0055 0.0174 0.0265
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0072 0.0107
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0081 0.0121
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0392 0.1002
Loa Loa (eye worm) hypothetical protein 0.011 0.0403 0.0616
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0023 0.0036 0.0049
Echinococcus multilocularis musashi 0.0027 0.0054 0.005
Schistosoma mansoni single-minded 0.0048 0.0145 0.0219
Onchocerca volvulus 0.0027 0.0054 0.022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0185 0.0281
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0021 0.0029 0.0041
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0242
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0332 0.0507
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0011 0.0015
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0043 0.0059
Loa Loa (eye worm) hypothetical protein 0.0058 0.0185 0.0282
Schistosoma mansoni smad1 5 8 and 0.0024 0.0043 0.0062
Echinococcus multilocularis Immunoglobulin 0.0021 0.0029 0.0025
Echinococcus multilocularis isocitrate dehydrogenase 0.0111 0.0408 0.0403
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0036 0.0053
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0024 0.0044 0.0088
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0068 0.0103
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Schistosoma mansoni ferritin light chain 0.0018 0.0016 0.0021
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0043 0.0062
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.01 0.0151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0208 0.0313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0011
Trichomonas vaginalis tubulin beta chain, putative 0.1171 0.4862 0.7468
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0023 0.0036 0.0032
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0023 0.0036 0.0032
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.018 0.0176
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0096 0.0092
Loa Loa (eye worm) hypothetical protein 0.0055 0.0174 0.0265
Brugia malayi tubulin alpha chain - mouse 0.1171 0.4862 0.7469
Echinococcus multilocularis ferritin 0.0018 0.0016 0.0012
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0023 0.0036 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0332 0.0504
Schistosoma mansoni DNA helicase recq5 0.0028 0.0061 0.009
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0104 0.038 0.0376
Brugia malayi hypothetical protein 0.0177 0.0685 0.105
Loa Loa (eye worm) tubulin alpha chain 0.1171 0.4862 0.7469
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.0174 0.0265
Brugia malayi Integrin beta pat-3 precursor 0.0311 0.1251 0.1919
Trypanosoma brucei PAB1-binding protein , putative 0.0177 0.0685 0.1047
Echinococcus multilocularis tubulin alpha 1C chain 0.1171 0.4862 0.486
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0115 0.0425 0.065
Brugia malayi Protein kinase domain containing protein 0.0152 0.0579 0.0887
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.004 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0208 0.0313
Treponema pallidum ATP-dependent RNA helicase 0.0024 0.0044 0.0257
Schistosoma mansoni tyrosine kinase 0.0246 0.0975 0.1496
Schistosoma mansoni nAChR subunit 0.0023 0.0036 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0015 0.0236
Echinococcus granulosus intermediate filament protein 0.0027 0.0054 0.0076
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0392 0.2366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0091 0.0133
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0208 0.0316
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0058 0.0185 0.0281
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0024 0.0044 0.0067
Schistosoma mansoni zinc finger protein 0.0052 0.0159 0.0241
Brugia malayi tubulin alpha-2 chain 0.1171 0.4862 0.7469
Entamoeba histolytica cysteine protease, putative 0.0017 0.0011 0.0017
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Brugia malayi SRC-1 0.0049 0.0146 0.0222
Schistosoma mansoni hypothetical protein 0.0066 0.022 0.0335
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0011
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0023 0.0036 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0028 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0021
Trypanosoma brucei tubulin gamma chain 0.0925 0.3829 0.5879
Echinococcus granulosus tm gpcr rhodopsin 0.0528 0.2162 0.3317
Toxoplasma gondii ABC1 family protein 0.0145 0.055 0.0841
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0443 0.1133
Echinococcus multilocularis glycine receptor subunit beta 0.0023 0.0036 0.0032
Brugia malayi glutaminase DH11.1 0.029 0.116 0.178
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Schistosoma mansoni nAChR subunit 0.0023 0.0036 0.0052
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0448 0.1826 0.2803
Echinococcus multilocularis tubulin gamma 1 chain 0.0925 0.3829 0.3826
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0042
Trypanosoma brucei epsilon tubulin 0.0872 0.3605 0.5535
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0543 0.0831
Schistosoma mansoni tubulin subunit beta 0.1563 0.6509 1
Trypanosoma brucei zeta tubulin 0.0946 0.3916 0.6014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0054 0.0076
Brugia malayi hypothetical protein 0.0052 0.0159 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.1378 0.5735 0.8811
Onchocerca volvulus 0.0145 0.055 0.2773
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0059 0.0084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0396 0.1605 0.2461
Echinococcus granulosus single minded 2 0.0036 0.0092 0.0135
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.01 0.0151
Brugia malayi MH1 domain containing protein 0.0024 0.0043 0.0063
Brugia malayi Nuclear hormone receptor-like 1 0.011 0.0403 0.0616
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.001 0.0012
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.005 0.0074
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.003 0.004
Schistosoma mansoni Smad4 0.0024 0.0043 0.0062
Trypanosoma cruzi epsilon tubulin, putative 0.0924 0.3825 0.5875
Trypanosoma brucei beta tubulin 0.1563 0.6509 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.004 0.0192
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0159 0.0241
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0208 0.0316
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0049 0.0146 0.0142
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0096 0.0147
Loa Loa (eye worm) Smad1 0.0024 0.0043 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0081 0.0118
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0011 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0645 0.0985
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.018 0.0274
Plasmodium falciparum alpha tubulin 1 0.1171 0.4862 0.7465
Treponema pallidum cell division protein FtsZ 0.0396 0.1605 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0111 0.0408 0.0623
Brugia malayi AMP-binding enzyme family protein 0.0024 0.004 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0054 0.0076
Echinococcus multilocularis Immunoglobulin 0.0021 0.0029 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0042
Loa Loa (eye worm) isocitrate dehydrogenase 0.0111 0.0408 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0052 0.0074
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0023 0.0036 0.0053
Loa Loa (eye worm) BEN-1 protein 0.1563 0.6509 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0217 0.0213
Schistosoma mansoni tubulin subunit delta 0.0396 0.1605 0.2464
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0023 0.0036 0.0049
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0036 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0217 0.0327
Loa Loa (eye worm) hypothetical protein 0.0055 0.0174 0.0265
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0028 0.0036
Brugia malayi glutathione reductase 0.0047 0.0139 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-19 0.011 0.0403 0.0616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0043 0.0059
Loa Loa (eye worm) tubulin alpha 2 0.0775 0.3198 0.4912
Echinococcus multilocularis beta tubulin 0.1563 0.6509 0.6508
Schistosoma mansoni nAChR subunit 0.0023 0.0036 0.0052
Loa Loa (eye worm) hypothetical protein 0.0115 0.0425 0.065
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0036 0.0053
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0775 0.3198 0.4912
Echinococcus granulosus tubulin alpha 0.0872 0.3605 0.5535
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0181 0.0276
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0091 0.0133
Loa Loa (eye worm) integrin alpha pat-2 0.0234 0.0927 0.1421
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Loa Loa (eye worm) hypothetical protein 0.0257 0.1024 0.157
Leishmania major beta tubulin 0.1563 0.6509 1
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0096 0.0141
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0252 0.1002 0.1534
Schistosoma mansoni tyrosine kinase 0.0252 0.1002 0.1537
Schistosoma mansoni integrin beta subunit 0.0183 0.0712 0.1091
Onchocerca volvulus Putative organic anion transporter 0.0055 0.0174 0.084
Schistosoma mansoni smad 0.0024 0.0043 0.0062
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0139 0.0338
Brugia malayi Tubulin beta-1 chain 0.1563 0.6509 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1014 0.1552
Schistosoma mansoni follistatin 0.0038 0.01 0.0151
Echinococcus granulosus Nuclear hormone receptor HR96 0.0052 0.0159 0.0238
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0618 0.2539 0.3899
Leishmania major alpha tubulin 0.1171 0.4862 0.7468
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Loa Loa (eye worm) patched family protein 0.0037 0.0096 0.0146
Echinococcus granulosus lamin dm0 0.0027 0.0054 0.0076
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0104 0.038 0.0578
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0096 0.0145
Giardia lamblia Alpha-tubulin 0.1171 0.4862 0.7465
Loa Loa (eye worm) ACC-1 protein 0.0023 0.0036 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-14 0.011 0.0403 0.0616
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0044 0.0063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0011
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0129 0.0195
Echinococcus granulosus Nuclear hormone receptor HR96 0.0052 0.0159 0.0238
Leishmania major beta tubulin 0.1563 0.6509 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0208 0.0313
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0257 0.1024 0.157
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0872 0.3605 0.5536
Schistosoma mansoni DNA helicase recq1 0.0028 0.0061 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0332 0.0507
Trichomonas vaginalis tubulin beta chain, putative 0.1563 0.6509 1
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0024 0.0044 0.006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0054 0.008
Loa Loa (eye worm) tubulin alpha 2 0.0299 0.1199 0.1839
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.093 0.1423
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0023 0.0036 0.0053
Brugia malayi hypothetical protein 0.0114 0.0422 0.0645
Trichomonas vaginalis tubulin beta chain, putative 0.1171 0.4862 0.7468
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0775 0.3198 0.4909
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0028 0.0036
Echinococcus multilocularis tubulin alpha chain 0.1171 0.4862 0.486
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0159 0.0155
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0208 0.0815 0.1246
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0118 0.0182
Onchocerca volvulus 0.0038 0.01 0.0459
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0036 0.0052
Brugia malayi hypothetical protein 0.0037 0.0096 0.0146
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0023 0.0036 0.0053
Brugia malayi Tyrosine-protein kinase abl-1 0.0098 0.0354 0.0541
Plasmodium vivax ataxin-2 like protein, putative 0.0177 0.0685 0.1053
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0016 0.0017
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0036 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0129 0.0192
Brugia malayi Furin-like cysteine rich region family protein 0.0467 0.1903 0.2921
Trypanosoma cruzi PAB1-binding protein , putative 0.0177 0.0685 0.1049
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Plasmodium vivax tubulin alpha chain, putative 0.1171 0.4862 0.7469
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0111 0.0408 0.062
Brugia malayi Tubulin beta chain 0.0396 0.1605 0.2464
Schistosoma mansoni steroid hormone receptor ad4bp 0.011 0.0403 0.0615
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0129 0.0192
Loa Loa (eye worm) ACC-1 protein 0.0023 0.0036 0.0053
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0038 0.01 0.0152
Echinococcus granulosus tumor protein p63 0.0336 0.1354 0.2074
Loa Loa (eye worm) hypothetical protein 0.0058 0.0185 0.0282
Trypanosoma brucei alpha tubulin 0.1171 0.4862 0.7468
Loa Loa (eye worm) integrin beta-2 0.0311 0.1251 0.1919
Brugia malayi Patched family protein 0.0037 0.0096 0.0146
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0332 0.0328
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0096 0.0132
Toxoplasma gondii LsmAD domain-containing protein 0.0177 0.0685 0.1049
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0023 0.0036 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0063 0.0091
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.001 0.0008
Brugia malayi beta-lactamase family protein 0.0145 0.055 0.0842
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Schistosoma mansoni tubulin subunit beta 0.0396 0.1605 0.2464
Brugia malayi Latrophilin receptor protein 2 0.0066 0.022 0.0336
Loa Loa (eye worm) glutathione reductase 0.0047 0.0139 0.0211
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Echinococcus granulosus GPCR family 2 0.0066 0.022 0.0332
Echinococcus multilocularis follistatin 0.0038 0.01 0.0096
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0101 0.0149
Mycobacterium ulcerans esterase/lipase LipP 0.0145 0.055 0.3383
Loa Loa (eye worm) hypothetical protein 0.0038 0.01 0.0152
Echinococcus multilocularis Niemann Pick C1 protein 0.0609 0.25 0.2496
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Echinococcus granulosus Tubulin beta 2C chain 0.1563 0.6509 1
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.018 0.027
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.01 0.0151
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0392 0.1002
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0181 0.0272
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0072 0.0246 0.0363
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0023 0.0036 0.0049
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0049 0.0146 0.0218
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.005 0.0254
Echinococcus multilocularis muscleblind protein 1 0.0166 0.0641 0.0637
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0111 0.0408 0.062
Brugia malayi PAS domain containing protein 0.0048 0.0145 0.022
Schistosoma mansoni thyroid hormone receptor 0.0235 0.0929 0.1424
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0036 0.0052
Loa Loa (eye worm) hypothetical protein 0.0084 0.0294 0.0449
Loa Loa (eye worm) TK protein kinase 0.0042 0.0118 0.0179
Trypanosoma cruzi tubulin delta chain 0.0725 0.2988 0.4588
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0242
Echinococcus granulosus tubulin alpha chain 0.1171 0.4862 0.7468
Mycobacterium leprae conserved hypothetical protein 0.0145 0.055 0.3356
Echinococcus granulosus tubulin delta chain 0.0396 0.1605 0.2461
Echinococcus granulosus tyrosine protein kinase Lyn 0.0049 0.0148 0.0221
Brugia malayi Patched protein homolog 1 0.0037 0.0096 0.0146
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0044 0.0063
Trichomonas vaginalis tubulin epsilon chain, putative 0.0396 0.1605 0.2461
Echinococcus multilocularis tubulin subunit beta 0.1563 0.6509 0.6508
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0528 0.2162 0.2159
Onchocerca volvulus 0.0478 0.1952 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0011 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0028 0.0036
Schistosoma mansoni cell adhesion molecule 0.0027 0.0054 0.0079
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0011 0.0014
Brugia malayi Cytochrome P450 family protein 0.0026 0.005 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0021
Schistosoma mansoni intermediate filament proteins 0.0027 0.0054 0.008
Schistosoma mansoni tyrosine kinase 0.0246 0.0975 0.1496
Trichomonas vaginalis DNA helicase recq, putative 0.0041 0.0113 0.0168
Trichomonas vaginalis tubulin beta chain, putative 0.1171 0.4862 0.7468
Schistosoma mansoni vesicular amine transporter 0.0021 0.0029 0.0041
Brugia malayi nuclear receptor RXR 0.0058 0.0185 0.0282
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Entamoeba histolytica hypothetical protein 0.0072 0.0246 0.0377
Onchocerca volvulus 0.0055 0.0174 0.084
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0061 0.0087
Loa Loa (eye worm) agrin synaptic family protein 0.0038 0.01 0.0152
Brugia malayi Myosin head containing protein 0.0037 0.0096 0.0146
Entamoeba histolytica tubulin family protein 0.1563 0.6509 1
Onchocerca volvulus 0.0052 0.0159 0.0761
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0185 0.0282
Echinococcus granulosus follistatin 0.0038 0.01 0.0148
Trichomonas vaginalis tubulin alpha chain, putative 0.0476 0.1941 0.2977
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0092 0.0087
Echinococcus granulosus Tubulin beta 2C chain 0.1563 0.6509 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0052 0.0159 0.0242
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0016 0.0087
Schistosoma mansoni hypothetical protein 0.0048 0.0143 0.0216
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.011 0.0403 0.0613
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0468 0.0463
Echinococcus granulosus Niemann Pick C1 protein 0.0609 0.25 0.3836
Brugia malayi hypothetical protein 0.0235 0.093 0.1426
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0181 0.0272
Loa Loa (eye worm) beta-lactamase 0.0145 0.055 0.0842
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0023 0.0036 0.0053
Schistosoma mansoni hypothetical protein 0.0066 0.022 0.0335
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.0011
Echinococcus granulosus tubulin alpha 1C chain 0.1171 0.4862 0.7468
Schistosoma mansoni hypothetical protein 0.1378 0.5735 0.8811
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0079 0.0275 0.0271
Trypanosoma brucei beta tubulin 0.0872 0.3605 0.5535
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Onchocerca volvulus 0.0037 0.0096 0.0439
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0208 0.0313
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0683 0.1043
Echinococcus granulosus tyrosine protein kinase Btk29A 0.002 0.0024 0.0031
Brugia malayi nuclear hormone receptor family member odr-7 0.0052 0.0159 0.0242
Schistosoma mansoni retinoic acid receptor RXR 0.0208 0.0815 0.1249
Leishmania major alpha tubulin 0.1171 0.4862 0.7468
Loa Loa (eye worm) acetyltransferase 0.0143 0.0543 0.0832
Echinococcus multilocularis hypothetical protein 0.1171 0.4862 0.486
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0111 0.0408 0.0403
Schistosoma mansoni hypothetical protein 0.0071 0.0241 0.0367
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0023 0.0036 0.0032
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0052 0.0159 0.0242
Leishmania major cytochrome p450-like protein 0.0026 0.005 0.0071
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.011 0.0403 0.0615
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0092 0.0088
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0072 0.0246 0.0374
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.018 0.0273
Trypanosoma cruzi epsilon tubulin, putative 0.0924 0.3825 0.5875
Loa Loa (eye worm) hypothetical protein 0.011 0.0403 0.0616
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.004 0.0192
Brugia malayi Patched related family protein 4 0.0037 0.0096 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.0403 0.0616
Brugia malayi Integrin alpha pat-2 precursor 0.0152 0.0581 0.0889
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0058 0.0086
Trichomonas vaginalis tubulin epsilon chain, putative 0.1171 0.4862 0.7468
Schistosoma mansoni tyrosine kinase 0.0252 0.1002 0.1537
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0111 0.0408 0.062
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0011 0.0007
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0023 0.0036 0.0049
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.005 0.0075
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.018 0.027
Leishmania major cathepsin L-like protease 0.0063 0.0208 0.0313
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0246 0.1444
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0103 0.0143
Onchocerca volvulus 0.011 0.0403 0.2017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0332 0.0328
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0024 0.0044 0.0039
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.001 0.0005
Onchocerca volvulus 0.0055 0.0174 0.084
Echinococcus multilocularis Tubulin beta 2C chain 0.1563 0.6509 0.6508
Loa Loa (eye worm) hypothetical protein 0.011 0.0403 0.0616
Echinococcus granulosus integrin alpha ps 0.0033 0.0079 0.0114
Trichomonas vaginalis esterase, putative 0.0145 0.055 0.0838
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0023 0.0036 0.0032
Plasmodium falciparum lipid/sterol:H+ symporter 0.0037 0.0096 0.0133
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1171 0.4862 0.7468
Leishmania major alpha tubulin 0.1171 0.4862 0.7468
Echinococcus multilocularis Tubulin alpha 1 chain 0.1171 0.4862 0.486
Schistosoma mansoni ferritin 0.0018 0.0016 0.0021
Leishmania major alpha tubulin 0.1171 0.4862 0.7468
Leishmania major gamma-tubulin 0.0925 0.3829 0.5879
Echinococcus granulosus Smad4 0.0024 0.0043 0.0059
Entamoeba histolytica tubulin family protein 0.1563 0.6509 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.01 0.0152
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.022 0.0332
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0023 0.0036 0.0052
Echinococcus granulosus alpha tubulin 0.1171 0.4862 0.7468
Loa Loa (eye worm) hypothetical protein 0.0177 0.0685 0.105
Brugia malayi Fibronectin type III domain containing protein 0.0024 0.0041 0.006
Loa Loa (eye worm) hypothetical protein 0.0119 0.0443 0.0678
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0036 0.0032
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0155 0.0591 0.0902
Toxoplasma gondii alpha-tubulin I, putative 0.1171 0.4862 0.7468
Trypanosoma brucei alpha tubulin 0.1171 0.4862 0.7468
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.011 0.0403 0.0615
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0146 0.0142
Brugia malayi Nuclear hormone receptor E75 0.0052 0.0159 0.0242
Echinococcus granulosus ecdysone induced protein 78C 0.011 0.0403 0.0613
Loa Loa (eye worm) hypothetical protein 0.0038 0.01 0.0152
Leishmania major alpha tubulin 0.1171 0.4862 0.7468
Giardia lamblia GTOR 0.0045 0.0129 0.0184
Plasmodium falciparum tubulin epsilon chain, putative 0.0924 0.3825 0.587
Echinococcus multilocularis tubulin alpha 3 chain 0.1171 0.4862 0.486
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0129 0.0192
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.001 0.0012
Loa Loa (eye worm) tubulin beta chain 0.0396 0.1605 0.2464
Echinococcus multilocularis cpg binding protein 0.0096 0.0344 0.034
Echinococcus granulosus glycine receptor subunit beta 0.0023 0.0036 0.0049
Loa Loa (eye worm) tubulin alpha-3 chain 0.0695 0.2863 0.4396
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0081
Echinococcus multilocularis tyrosine protein kinase Blk 0.0042 0.0118 0.0114
Onchocerca volvulus Protein patched homolog 0.0037 0.0096 0.0439
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0011 0.0002
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0072 0.0104
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0028 0.0036
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0096 0.0141
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0042 0.0118 0.0175
Brugia malayi Niemann-Pick C1 protein precursor 0.0609 0.25 0.3839
Loa Loa (eye worm) tubulin gamma chain 0.0925 0.3829 0.5881
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0011 0.0017
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0044 0.006
Echinococcus granulosus beta tubulin 0.1563 0.6509 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0059
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0043 0.0038
Toxoplasma gondii patched family protein 0.0037 0.0096 0.0145
Brugia malayi hypothetical protein 0.0024 0.0041 0.006
Brugia malayi intermediate filament protein 0.0027 0.0054 0.008
Echinococcus granulosus cpg binding protein 0.0096 0.0344 0.0522
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0058 0.0185 0.0181
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0543 0.0539
Brugia malayi secreted modular calcium-binding protein 1 0.0038 0.01 0.0152
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0118 0.0114
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0129 0.0196
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0036 0.0049
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.011 0.0403 0.0399
Leishmania major beta tubulin 0.1563 0.6509 1
Brugia malayi tailless protein 0.0052 0.0159 0.0242
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0052 0.0159 0.0242
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1014 0.1552
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.001 0.0012
Schistosoma mansoni alpha tubulin 0.1171 0.4862 0.7468
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0052 0.0159 0.0155
Entamoeba histolytica tubulin alpha-1 chain 0.1171 0.4862 0.7469
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0011
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.018 0.027
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0049 0.0146 0.0142
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.011 0.0403 0.0399
Echinococcus granulosus neuropeptide receptor A26 0.0471 0.1922 0.2948
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0043 0.0059
Schistosoma mansoni nuclear receptor nhr-48 0.0052 0.0159 0.0241
Echinococcus multilocularis Tubulin beta 2C chain 0.1563 0.6509 0.6508
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Toxoplasma gondii isocitrate dehydrogenase 0.0111 0.0408 0.0623
Toxoplasma gondii thioredoxin reductase 0.0047 0.0139 0.021
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0015
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0024 0.0044 0.006
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0645 0.3265
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.011 0.0403 0.2017
Loa Loa (eye worm) hypothetical protein 0.0145 0.055 0.0842
Echinococcus granulosus epidermal growth factor receptor 0.0467 0.1903 0.2918
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0096 0.0092
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0143 0.0544 0.0833
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0052 0.0159 0.0761
Loa Loa (eye worm) beta-tubulin 0.1563 0.6509 1
Schistosoma mansoni hypothetical protein 0.0125 0.0468 0.0715
Trichomonas vaginalis tubulin epsilon chain, putative 0.1563 0.6509 1
Schistosoma mansoni tyrosine kinase 0.0049 0.0146 0.0221
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0043 0.0063
Mycobacterium ulcerans hypothetical protein 0.0024 0.004 0.0192
Trypanosoma cruzi tubulin gamma chain 0.0925 0.3829 0.588
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.004 0.008
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0143 0.0544 0.0833
Echinococcus granulosus roundabout 2 0.003 0.0066 0.0095
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Brugia malayi protein C24B5.3 0.0037 0.0096 0.0146
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0091
Mycobacterium tuberculosis Probable esterase LipL 0.0145 0.055 0.1414
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0924 0.3827 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0015 0.0009
Brugia malayi Muscleblind-like protein 0.0166 0.0641 0.0982
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0052 0.0159 0.0155
Toxoplasma gondii hypothetical protein 0.0037 0.0096 0.0145
Echinococcus granulosus expressed protein 0.0018 0.0016 0.0018
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.01 0.0152
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0041 0.006
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0052 0.0159 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-31 0.011 0.0403 0.0616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0011
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0695 0.2863 0.4394
Loa Loa (eye worm) hypothetical protein 0.011 0.0403 0.0616
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0257 0.1024 0.1569
Echinococcus granulosus Tubulin beta 2C chain 0.1563 0.6509 1
Echinococcus multilocularis c src tyrosine kinase 0.002 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.0145 0.055 0.0842
Loa Loa (eye worm) glutaminase 2 0.029 0.116 0.178
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0118
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0111 0.0408 0.0623
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.022 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0091 0.0133
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0111 0.0408 0.1042
Loa Loa (eye worm) hypothetical protein 0.011 0.0403 0.0616
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.004 0.0192
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0023 0.0036 0.0053
Schistosoma mansoni cpg binding protein 0.0096 0.0344 0.0525
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0476 0.1941 0.2977
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.002 0.0024 0.002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.011 0.0403 0.0615
Brugia malayi Nuclear hormone receptor family member nhr-19 0.011 0.0403 0.0616
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0016 0.0017
Plasmodium falciparum thioredoxin reductase 0.0047 0.0139 0.0199
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.001 0.0012
Echinococcus multilocularis Tubulin alpha 1 chain 0.1171 0.4862 0.486
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0145 0.055 0.1414
Trypanosoma cruzi tubulin delta chain 0.0725 0.2988 0.4588
Onchocerca volvulus 0.0055 0.0174 0.084
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0072 0.0104
Echinococcus multilocularis agrin 0.0038 0.01 0.0096
Loa Loa (eye worm) hypothetical protein 0.011 0.0403 0.0616
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0072 0.0246 0.1478
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0024 0.0042 0.0057
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0061 0.0091
Brugia malayi nuclear hormone receptor 0.011 0.0403 0.0616
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0054 0.008
Echinococcus granulosus L aminoadipate semialdehyde 0.0257 0.1024 0.1567
Leishmania major cathepsin L-like protease 0.0063 0.0208 0.0313
Echinococcus granulosus Tubulin alpha 1 chain 0.1171 0.4862 0.7468
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Onchocerca volvulus 0.0145 0.055 0.2773
Echinococcus granulosus tubulin beta 1 chain 0.1563 0.6509 1
Plasmodium vivax glutathione reductase, putative 0.0047 0.0139 0.0214
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.0011
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0052 0.0159 0.0761
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0059
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0064
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0036 0.0049
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0181 0.0275
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.015 0.0571 0.0567
Loa Loa (eye worm) cysteine protease 0.0017 0.0011 0.0015
Loa Loa (eye worm) alpha-tubulin 0.1171 0.4862 0.7469
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0023 0.0036 0.0053
Mycobacterium tuberculosis Probable hydrolase 0.0145 0.055 0.1414
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.093 0.0926
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0036 0.0052
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0023 0.0036 0.0049
Loa Loa (eye worm) hypothetical protein 0.0145 0.055 0.0842
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.001 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-3 0.011 0.0403 0.0616
Loa Loa (eye worm) hypothetical protein 0.0225 0.0886 0.1359
Schistosoma mansoni smad1 5 8 and 0.0024 0.0043 0.0062
Echinococcus multilocularis nAChR subunit 0.0023 0.0036 0.0032
Giardia lamblia Beta tubulin 0.1563 0.6509 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0096 0.0144
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0242
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0028 0.0036
Leishmania major hypothetical protein, conserved 0.0145 0.055 0.0838
Leishmania major epsilon tubulin, putative 0.0924 0.3825 0.5874
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0111 0.0408 0.0623
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0159 0.0238
Schistosoma mansoni survival motor neuron protein 0.0048 0.0143 0.0216
Brugia malayi hypothetical protein 0.0058 0.0185 0.0282
Loa Loa (eye worm) hypothetical protein 0.0145 0.055 0.0842
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0023 0.0036 0.0053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0192 0.0749 0.1147
Brugia malayi Nuclear hormone receptor family member nhr-1 0.011 0.0403 0.0616
Schistosoma mansoni ferritin 0.0018 0.0016 0.0021
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0129 0.0192
Brugia malayi nuclear receptor NHR-67 0.0052 0.0159 0.0242
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.011 0.0403 0.0399
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0217 0.0327
Echinococcus granulosus Solute carrier organic anion transporter family 0.0055 0.0174 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-40 0.011 0.0403 0.0616
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0246 0.0371
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Schistosoma mansoni patched 1 0.0261 0.1039 0.1594
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0146
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.055 0.0838
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0036 0.0049
Leishmania major cathepsin L-like protease 0.0063 0.0208 0.0313
Loa Loa (eye worm) hypothetical protein 0.0055 0.0174 0.0265
Loa Loa (eye worm) hypothetical protein 0.0166 0.0641 0.0982
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0053
Schistosoma mansoni organic anion transporter 0.0055 0.0174 0.0264
Leishmania major beta tubulin 0.1563 0.6509 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.011 0.0403 0.0613
Schistosoma mansoni tubulin subunit beta 0.1563 0.6509 1
Schistosoma mansoni tubulin subunit alpha 0.1171 0.4862 0.7468
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0023 0.0036 0.0049
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0322 0.0492
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0092 0.0134
Echinococcus granulosus muscleblind protein 0.0166 0.0641 0.0979
Schistosoma mansoni retinoid-x-receptor (RXR) 0.011 0.0403 0.0615
Mycobacterium tuberculosis Cell division protein FtsZ 0.0396 0.1605 0.418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.011 0.0403 0.0616
Plasmodium vivax tubulin alpha chain, putative 0.1171 0.4862 0.7469
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0011 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0028 0.0036

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 126 nM In vitro concentration required to inhibit peak currents in cerebral cortical neurones of rat ChEMBL. 15658856
Ki (binding) = 250 nM Displacement of [3H]-muscimol from rat brain gamma-aminobutyric-acid GABA-A receptor ChEMBL. 15658856
Ki (binding) = 250 nM Displacement of [3H]-muscimol from rat brain gamma-aminobutyric-acid GABA-A receptor ChEMBL. 15658856

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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