Detailed information for compound 507962

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 530.736 | Formula: C32H50O6
  • H donors: 1 H acceptors: 4 LogP: 7.34 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)C[C@@]1(C)C(CC[C@@]2(C1CC[C@@]1(C2=CC[C@@]2(C1CC(C)(C)CC2)C(=O)O)C)C)C(C(=O)OC)(C)C
  • InChi: 1S/C32H50O6/c1-27(2)16-17-32(25(34)35)15-12-21-29(5)13-10-20(28(3,4)26(36)38-9)31(7,19-24(33)37-8)22(29)11-14-30(21,6)23(32)18-27/h12,20,22-23H,10-11,13-19H2,1-9H3,(H,34,35)/t20?,22?,23?,29-,30+,31-,32+/m0/s1
  • InChiKey: VVMGZVYQOSAGQE-SKEGJRNISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0037 0.0152
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.0027 0.0027
Echinococcus granulosus Nuclear hormone receptor HR96 0.0119 0.1424 0.1424
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0013 0.0037 0.0118
Echinococcus granulosus Ankyrin 0.0016 0.0082 0.0082
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0013 0.0037 0.0064
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0006 0.0021
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0019 0.0119 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0252 0.3164 0.3374
Echinococcus granulosus heat shock protein 0.0051 0.0542 0.0542
Schistosoma mansoni Smad4 0.0018 0.0104 0.0104
Mycobacterium tuberculosis Probable oxidoreductase 0.0013 0.0037 0.0064
Mycobacterium tuberculosis Probable oxidoreductase 0.0013 0.0037 0.0064
Echinococcus granulosus geminin 0.0562 0.7229 0.7229
Echinococcus multilocularis lamin dm0 0.003 0.0265 0.0265
Echinococcus multilocularis Smad4 0.0018 0.0104 0.0104
Brugia malayi Cathepsin L-like precursor 0.0017 0.0095 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0252 0.3164 0.3374
Onchocerca volvulus 0.0013 0.0037 0.0118
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0037 0.0064
Brugia malayi nuclear hormone receptor 0.0119 0.1424 0.1518
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0061 0.0061
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.0154
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Loa Loa (eye worm) hypothetical protein 0.0119 0.1424 0.1518
Mycobacterium ulcerans carveol-like dehydrogenase 0.0013 0.0037 0.0064
Plasmodium vivax heat shock protein 90, putative 0.0034 0.0316 0.1307
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.004
Echinococcus granulosus caspase 0.0019 0.0119 0.0119
Echinococcus multilocularis retinol dehydrogenase 11 0.0013 0.0037 0.0037
Entamoeba histolytica heat shock protein 90, putative 0.0051 0.0542 0.2233
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0013 0.0037 0.0037
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0119 0.1424 0.1518
Brugia malayi Protein kinase domain containing protein 0.0017 0.0088 0.0093
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0545 0.7457
Trypanosoma cruzi heat shock protein 90, putative 0.0044 0.0445 0.6077
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0013 0.0037 0.0064
Brugia malayi Cathepsin L-like precursor 0.0017 0.0095 0.0101
Echinococcus multilocularis voltage gated potassium channel 0.0015 0.0071 0.0071
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0195 0.2427 0.2427
Plasmodium vivax vivapain-2 0.0017 0.0095 0.0391
Echinococcus multilocularis apoptotic protease activating factor 1 0.0044 0.0451 0.0451
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0095 0.1193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0252 0.3164 0.3374
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0095 0.1193
Leishmania major quinonoid dihydropteridine reductase 0.0013 0.0037 0.0064
Leishmania major short chain dehydrogenase-like protein 0.0013 0.0037 0.0064
Schistosoma mansoni nuclear hormone receptor 0.0119 0.1424 0.1424
Onchocerca volvulus Cell death protein 3 homolog 0.0063 0.0701 0.2215
Onchocerca volvulus 0.0013 0.0037 0.0118
Echinococcus granulosus retinol dehydrogenase 11 0.0013 0.0037 0.0037
Brugia malayi latrophilin 2 splice variant baaae 0.0114 0.1368 0.1458
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0095 0.0095
Loa Loa (eye worm) MH2 domain-containing protein 0.0263 0.3307 0.3527
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0081 0.0086
Brugia malayi steroid hormone receptor 0.0252 0.3164 0.3374
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0013 0.0037 0.0438
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0119 0.1573
Loa Loa (eye worm) oxidoreductase 0.0013 0.0037 0.004
Mycobacterium tuberculosis Possible oxidoreductase 0.0013 0.0037 0.0064
Plasmodium falciparum heat shock protein 90 0.0051 0.0542 0.212
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0013 0.0037 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0729 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0013 0.0037 0.0152
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0101
Brugia malayi Nuclear hormone receptor E75 0.0119 0.1424 0.1518
Onchocerca volvulus 0.0017 0.0095 0.03
Mycobacterium tuberculosis Probable oxidoreductase 0.0013 0.0037 0.0064
Schistosoma mansoni hypothetical protein 0.0016 0.0081 0.0081
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0037 0.0037
Plasmodium vivax vivapain-2 0.0017 0.0095 0.0391
Loa Loa (eye worm) oxidoreductase 0.0013 0.0037 0.004
Schistosoma mansoni retinoic acid receptor RXR 0.0252 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0207 0.2585 0.2757
Mycobacterium ulcerans dehydrogenase/reductase 0.0013 0.0037 0.0064
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0013 0.0037 0.0214
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0013 0.0037 0.0438
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0013 0.0037 0.0144
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0095 0.0095
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0027 0.0029
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0006 0.0023
Schistosoma mansoni retinal dehydrogenase 0.0013 0.0037 0.0037
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0022
Echinococcus granulosus caspase 2 0.0063 0.0701 0.0701
Brugia malayi Cathepsin L-like precursor 0.0017 0.0095 0.0101
Onchocerca volvulus 0.0013 0.0037 0.0118
Entamoeba histolytica heat shock protein 90, putative 0.0051 0.0542 0.2233
Brugia malayi Dehydrogenases, short chain protein 30 0.0013 0.0037 0.004
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0071 0.0071
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0563 0.06
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0013 0.0037 0.0037
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0013 0.0037 0.0269
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.004
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0013 0.0037 0.0037
Onchocerca volvulus 0.0013 0.0037 0.0118
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0104 0.0104
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0037 0.0269
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0013 0.0037 0.0438
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0136 0.0564
Leishmania major hypothetical protein, conserved 0.0013 0.0037 0.0064
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0013 0.0037 0.004
Schistosoma mansoni hypothetical protein 0.0053 0.0563 0.0563
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0095 0.1193
Trypanosoma brucei heat shock protein 90, putative 0.0051 0.0542 0.7342
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.0037 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0252 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0119 0.1424 0.1518
Brugia malayi Nuclear hormone receptor E75 0.0119 0.1424 0.1518
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0019 0.0119 0.0127
Plasmodium vivax metacaspase 1, putative 0.0019 0.0119 0.0492
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0095 0.1193
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0252 0.3164 0.3164
Loa Loa (eye worm) steroid hormone receptor 0.0252 0.3164 0.3374
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0133 0.161 0.161
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0645 0.0645
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Echinococcus multilocularis cysteine protease 0.0017 0.0095 0.0095
Trypanosoma brucei metacaspase 5, putative 0.0019 0.0119 0.1313
Leishmania major cathepsin L-like protease 0.0066 0.0729 0.441
Loa Loa (eye worm) hypothetical protein 0.003 0.0265 0.0283
Schistosoma mansoni carbonyl reductase 0.0013 0.0037 0.0037
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Trypanosoma brucei heat shock protein, putative 0.0051 0.0542 0.7342
Toxoplasma gondii oxidoreductase, putative 0.0013 0.0037 0.0154
Loa Loa (eye worm) hypothetical protein 0.0252 0.3164 0.3374
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0012 0.0027 0.0299
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0645 0.2668
Loa Loa (eye worm) hypothetical protein 0.0014 0.0053 0.0057
Schistosoma mansoni hypothetical protein 0.0195 0.2427 0.2427
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0358 0.5398
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0265 0.0283
Entamoeba histolytica short chain dehydrogenase family protein 0.0013 0.0037 0.0152
Echinococcus granulosus bloom syndrome protein 0.002 0.0136 0.0136
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0095 0.0095
Brugia malayi Nuclear hormone receptor-like 1 0.0133 0.161 0.1717
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0133 0.161 0.161
Toxoplasma gondii cathepsin CPL 0.0017 0.0095 0.0393
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0037 0.0269
Loa Loa (eye worm) cysteine protease 0.0017 0.0095 0.0101
Loa Loa (eye worm) hypothetical protein 0.0252 0.3164 0.3374
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.004
Echinococcus granulosus hyperpolarization activated cyclic 0.0012 0.0025 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0252 0.3164 0.3374
Mycobacterium tuberculosis Probable oxidoreductase 0.0013 0.0037 0.0064
Echinococcus granulosus WW domain containing oxidoreductase 0.0013 0.0037 0.0037
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.0037 0.0037
Schistosoma mansoni caspase-7 (C14 family) 0.0019 0.0119 0.0119
Trypanosoma cruzi short chain dehydrogenase, putative 0.0013 0.0037 0.0438
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.004
Brugia malayi hypothetical protein 0.0119 0.1424 0.1518
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0542 0.835
Entamoeba histolytica short chain dehydrogenase family protein 0.0013 0.0037 0.0152
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0034 0.0316 0.1302
Brugia malayi N-terminal motif family protein 0.0207 0.2585 0.2757
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0645 1
Brugia malayi hypothetical protein 0.0195 0.2427 0.2588
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0012 0.0027 0.0299
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0119 0.1582
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0013 0.0037 0.0438
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0729 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0012 0.0025 0.0025
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0136 0.0136
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0037 0.0037
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0136 0.1856
Schistosoma mansoni heat shock protein 0.0051 0.0542 0.0542
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0037 0.0438
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0252 0.3164 0.3374
Loa Loa (eye worm) hypothetical protein 0.0252 0.3164 0.3374
Brugia malayi hypothetical protein 0.0133 0.161 0.1717
Brugia malayi hypothetical protein 0.0119 0.1424 0.1518
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0252 0.3164 0.3164
Leishmania major cytochrome p450-like protein 0.0042 0.0417 0.2453
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0013 0.0037 0.0064
Echinococcus multilocularis jun protein 0.0091 0.106 0.106
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0025 0.0025
Toxoplasma gondii heat shock protein 90, putative 0.0051 0.0542 0.2242
Brugia malayi Steroid receptor seven-up type 2 0.0252 0.3164 0.3374
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0645 0.8811
Plasmodium falciparum heat shock protein 90, putative 0.003 0.0261 0.0938
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0104 0.0104
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0252 0.3164 0.3164
Loa Loa (eye worm) oxidoreductase 0.0013 0.0037 0.004
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0037 0.0269
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0034 0.0316 0.1
Echinococcus granulosus lamin dm0 0.003 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0014 0.0053 0.0057
Schistosoma mansoni aldehyde dehydrogenase 0.0134 0.1618 0.1618
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0729 1
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.0542 0.7421
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0252 0.3164 0.3374
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0021 0.0021
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0015 0.0071 0.0075
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0021 0.0022
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0252 0.3164 0.3164
Schistosoma mansoni smad 0.0018 0.0104 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0729 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0119 0.1582
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0037 0.0037
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0048 0.0501 1
Echinococcus multilocularis endoplasmin 0.0048 0.0501 0.0501
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0645 0.8846
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Mycobacterium tuberculosis Possible oxidoreductase 0.0013 0.0037 0.0064
Loa Loa (eye worm) hypothetical protein 0.0339 0.4306 0.4592
Onchocerca volvulus 0.0071 0.0804 0.2542
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0048 0.0501 0.2978
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0015 0.0071 0.0071
Entamoeba histolytica hypothetical protein 0.0195 0.2427 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.1618 1
Brugia malayi intermediate filament protein 0.003 0.0265 0.0283
Loa Loa (eye worm) oxidoreductase 0.0013 0.0037 0.004
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0013 0.0037 0.0064
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0406 0.519 0.519
Onchocerca volvulus 0.0013 0.0037 0.0118
Echinococcus multilocularis musashi 0.003 0.0265 0.0265
Brugia malayi RNA binding protein 0.0071 0.0799 0.0853
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0095 0.1193
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0081 0.0081
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0645 1
Leishmania major oxidoreductase-like protein 0.0013 0.0037 0.0064
Echinococcus multilocularis nuclear receptor nhr 48 0.0119 0.1424 0.1424
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0119 0.1582
Brugia malayi Cathepsin L-like precursor 0.0017 0.0095 0.0101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0095 0.1193
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0013 0.0037 0.0037
Schistosoma mansoni nuclear receptor 0.0119 0.1424 0.1424
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0645 1
Mycobacterium ulcerans ketoacyl reductase 0.0013 0.0037 0.0064
Loa Loa (eye worm) intermediate filament protein 0.003 0.0265 0.0283
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Schistosoma mansoni microtubule-associated protein tau 0.0774 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0081 0.0255
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0136 0.181
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0013 0.0037 0.0438
Brugia malayi bZIP transcription factor family protein 0.0091 0.106 0.113
Loa Loa (eye worm) nuclear receptor NHR-67 0.0119 0.1424 0.1518
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0445 0.6077
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0119 0.1424 0.1424
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0 0.0002
Plasmodium vivax heat shock protein, putative 0.0195 0.2419 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0019 0.0119 0.0119
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0015 0.0071 0.0071
Brugia malayi dehydrogenases, short chain protein 9 0.0013 0.0037 0.004
Schistosoma mansoni smad1 5 8 and 0.0018 0.0104 0.0104
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0645 0.0645
Echinococcus granulosus GPCR family 2 0.0053 0.0563 0.0563
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0037 0.0438
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0044 0.0445 0.0445
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0095 0.1193
Schistosoma mansoni heat shock protein 0.0034 0.0316 0.0316
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0013 0.0037 0.0064
Schistosoma mansoni caspase-7 (C14 family) 0.0063 0.0701 0.0701
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0012 0.0025 0.0025
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Brugia malayi nuclear receptor NHR-88 0.0119 0.1424 0.1518
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0012 0.0025 0.0025
Loa Loa (eye worm) transcription factor SMAD2 0.0263 0.3307 0.3527
Echinococcus multilocularis retinol dehydrogenase 11 0.0013 0.0037 0.0037
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0119 0.1582
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0729 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0083 0.0951 0.0951
Echinococcus granulosus retinol dehydrogenase 11 0.0013 0.0037 0.0037
Brugia malayi Cytochrome P450 family protein 0.0012 0.0027 0.0029
Brugia malayi nuclear receptor NHR-67 0.0119 0.1424 0.1518
Echinococcus multilocularis caspase 2 0.0063 0.0701 0.0701
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Leishmania major hypothetical protein, conserved 0.0013 0.0037 0.0064
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0469 0.0469
Brugia malayi Nuclear hormone receptor-like 1 0.0133 0.161 0.1717
Loa Loa (eye worm) oxidoreductase 0.0013 0.0037 0.004
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0091 0.106 0.106
Echinococcus granulosus lamin 0.003 0.0265 0.0265
Brugia malayi MH2 domain containing protein 0.0263 0.3307 0.3527
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0119 0.1582
Trypanosoma brucei heat shock protein, putative 0.0051 0.0542 0.7342
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0037 0.0037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0252 0.3164 0.3374
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0037 0.0269
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0645 0.3885
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0013 0.0037 0.0144
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.0154
Giardia lamblia Heat shock protein HSP 90-alpha 0.0044 0.0445 0.6706
Leishmania major hypothetical protein, conserved 0.0013 0.0037 0.0064
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0095 0.0242
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0013 0.0037 0.0037
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0013 0.0037 0.0064
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0013 0.0037 0.0154
Trichomonas vaginalis heat shock protein, putative 0.0048 0.0501 0.7689
Entamoeba histolytica hypothetical protein 0.0195 0.2427 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0095 0.0101
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0799 0.0799
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0252 0.3164 0.3374
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0012 0.0025 0.0027
Mycobacterium ulcerans oxidoreductase 0.0013 0.0037 0.0064
Brugia malayi orphan nuclear receptor NR2E1 0.0119 0.1424 0.1518
Onchocerca volvulus 0.0119 0.1424 0.4499
Echinococcus granulosus tar DNA binding protein 0.0071 0.0799 0.0799
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0252 0.3164 0.3164
Trypanosoma brucei heat shock protein, putative 0.0051 0.0542 0.7342
Onchocerca volvulus 0.0017 0.0095 0.03
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Leishmania major metacaspase, putative 0.0019 0.0119 0.0579
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0013 0.0037 0.0037
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Schistosoma mansoni hypothetical protein 0.0053 0.0563 0.0563
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0013 0.0037 0.0152
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0729 1
Brugia malayi hypothetical protein 0.0013 0.0037 0.004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0252 0.3164 0.3164
Toxoplasma gondii cytochrome p450 superfamily protein 0.0012 0.0027 0.0112
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.004
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0095 0.1193
Schistosoma mansoni smad1 5 8 and 0.0018 0.0104 0.0104
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0445 0.6795
Schistosoma mansoni endoplasmin 0.0051 0.0542 0.0542
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0013 0.0037 0.0118
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Toxoplasma gondii heat shock protein 75, putative 0.0034 0.0316 0.1308
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.0542 0.7421
Leishmania major quinonoid dihydropteridine reductase 0.0013 0.0037 0.0064
Brugia malayi cathepsin L-like precursor 0.0012 0.0021 0.0022
Giardia lamblia Heat shock protein HSP 90-alpha 0.0051 0.0542 0.8305
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0095 0.1193
Echinococcus multilocularis thyroid hormone receptor alpha 0.0658 0.8485 0.8485
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0025 0.0025
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0095 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0252 0.3164 0.3374
Loa Loa (eye worm) DR-78 0.0119 0.1424 0.1518
Echinococcus multilocularis heat shock protein 0.0051 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0015 0.0061 0.0065
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.0542 0.7421
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0133 0.161 0.161
Leishmania major short chain dehydrogenase/reductase, putative 0.0013 0.0037 0.0064
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0119 0.1582
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0034 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0119 0.1424 0.1518
Echinococcus multilocularis Ankyrin 0.0016 0.0082 0.0082
Toxoplasma gondii heat shock protein HSP90 0.0051 0.0542 0.2242
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0102 0.1211 0.1292
Loa Loa (eye worm) hypothetical protein 0.0133 0.161 0.1717
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0013 0.0037 0.0438
Echinococcus granulosus Smad4 0.0018 0.0104 0.0104
Schistosoma mansoni carbonyl reductase 0.0013 0.0037 0.0037
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0252 0.3164 0.3164
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0013 0.0037 0.0269
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0799 0.0799
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Loa Loa (eye worm) hypothetical protein 0.0133 0.161 0.1717
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0252 0.3164 0.3164
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0563 0.06
Leishmania major cathepsin L-like protease 0.0017 0.0095 0.0427
Schistosoma mansoni hypothetical protein 0.0012 0.0027 0.0027
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0013 0.0037 0.0118
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0136 0.1631
Trichomonas vaginalis endoplasmin, putative 0.0037 0.0358 0.5398
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0645 1
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0645 0.0645
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0252 0.3164 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.0424 0.0424
Onchocerca volvulus 0.0013 0.0037 0.0118
Trypanosoma brucei Metacaspase-4 0.0019 0.0119 0.1313
Plasmodium falciparum metacaspase 1 0.0019 0.0119 0.0344
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0214
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0012 0.0025 0.0025
Leishmania major quinonoid dihydropteridine reductase 0.0013 0.0037 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0027
Leishmania major short chain dehydrogenase/reductase, putative 0.0013 0.0037 0.0064
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0037 0.0037
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Brugia malayi Dehydrogenases, short chain protein 2 0.0013 0.0037 0.004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0119 0.1424 0.1424
Brugia malayi follicle stimulating hormone receptor 0.0726 0.9377 1
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0013 0.0037 0.0144
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0012 0.0025 0.0073
Brugia malayi nuclear receptor RXR 0.0119 0.1424 0.1518
Schistosoma mansoni DNA helicase recq5 0.002 0.0136 0.0136
Brugia malayi Cytochrome P450 family protein 0.0012 0.0027 0.0029
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.004
Loa Loa (eye worm) Smad1 0.0018 0.0104 0.0111
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0037 0.0269
Schistosoma mansoni zinc finger protein 0.0119 0.1424 0.1424
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0095 0.03
Onchocerca volvulus 0.0013 0.0037 0.0118
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Brugia malayi Cytochrome P450 family protein 0.0042 0.0417 0.0445
Schistosoma mansoni jun-related protein 0.0074 0.0837 0.0837
Brugia malayi photoreceptor-specific nuclear receptor 0.0252 0.3164 0.3374
Loa Loa (eye worm) hypothetical protein 0.0102 0.1211 0.1292
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Entamoeba histolytica hypothetical protein, conserved 0.0013 0.0037 0.0152
Onchocerca volvulus 0.0017 0.0095 0.03
Echinococcus multilocularis FTZ F1 alpha 0.0252 0.3164 0.3164
Schistosoma mansoni hypothetical protein 0.0074 0.0837 0.0837
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0013 0.0037 0.0037
Brugia malayi MH1 domain containing protein 0.0018 0.0104 0.0111
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0119 0.1582
Loa Loa (eye worm) dehydrogenase 0.0013 0.0037 0.004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0252 0.3164 0.3164
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0013 0.0037 0.0064
Loa Loa (eye worm) hypothetical protein 0.0088 0.1027 0.1095
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0013 0.0037 0.0438
Onchocerca volvulus 0.0119 0.1424 0.4499
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0406 0.519 0.519
Loa Loa (eye worm) hypothetical protein 0.0252 0.3164 0.3374
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0119 0.1424 0.1424
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0252 0.3164 0.3164
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0645 0.3885
Brugia malayi ecdysteroid receptor 0.0252 0.3164 0.3374
Trypanosoma cruzi heat shock protein 90, putative 0.0051 0.0542 0.7421
Trypanosoma brucei short-chain dehydrogenase, putative 0.0013 0.0037 0.0144
Trypanosoma brucei heat shock protein, putative 0.0051 0.0542 0.7342
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0645 0.0645
Echinococcus multilocularis cysteine protease 0.0017 0.0095 0.0095
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0012 0.0025 0.0025
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0013 0.0037 0.0064
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0645 0.0688
Mycobacterium ulcerans ketoacyl reductase 0.0013 0.0037 0.0064
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0013 0.0037 0.0037
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0095 0.03
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0252 0.3164 0.3374
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0119 0.1424 0.1424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0729 1
Echinococcus granulosus intermediate filament protein 0.003 0.0265 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0119 0.1582
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Echinococcus granulosus voltage gated potassium channel 0.0015 0.0071 0.0071
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0012 0.0027 0.0299
Brugia malayi Cathepsin L-like precursor 0.0012 0.0021 0.0022
Echinococcus multilocularis steroid dehydrogenase 0.0013 0.0037 0.0037
Onchocerca volvulus 0.0017 0.0095 0.03
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.004
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Echinococcus granulosus death domain containing protein 0.0016 0.0081 0.0081
Toxoplasma gondii Hsp90 domain-containing protein 0.0195 0.2419 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0013 0.0037 0.0064
Echinococcus granulosus carbonyl reductase 1 0.0013 0.0037 0.0037
Schistosoma mansoni lamin 0.003 0.0265 0.0265
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0645 0.8846
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0417 0.5696
Trypanosoma brucei heat shock protein, putative 0.0051 0.0542 0.7342
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Loa Loa (eye worm) hypothetical protein 0.0119 0.1424 0.1518
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0119 0.0493
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0013 0.0037 0.0144
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0119 0.1582
Leishmania major cathepsin L-like protease 0.0066 0.0729 0.441
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0252 0.3164 0.3164
Schistosoma mansoni eyes absent homolog 0.0102 0.1211 0.1211
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0119 0.1582
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0133 0.161 0.161
Brugia malayi Nuclear hormone receptor-like 1 0.0252 0.3164 0.3374
Schistosoma mansoni aldehyde dehydrogenase 0.0134 0.1618 0.1618
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0095 0.1193
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Brugia malayi conserved hypotetical protein 0.0119 0.1424 0.1518
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0082 0.0087
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0119 0.1424 0.1518
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0127
Plasmodium falciparum metacaspase-like protein 0.0019 0.0119 0.0344
Onchocerca volvulus 0.003 0.0265 0.0839
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Loa Loa (eye worm) fibroinase 0.0017 0.0095 0.0101
Schistosoma mansoni hypothetical protein 0.0053 0.0563 0.0563
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0645 0.8846
Brugia malayi TAR-binding protein 0.0071 0.0799 0.0853
Leishmania major cathepsin L-like protease 0.0017 0.0095 0.0427
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0013 0.0037 0.0438
Schistosoma mansoni nuclear hormone receptor 0.0119 0.1424 0.1424
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0119 0.1424 0.4499
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Mycobacterium ulcerans ketoacyl reductase 0.0013 0.0037 0.0064
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0095 0.03
Onchocerca volvulus 0.0013 0.0037 0.0118
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.0154
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0207 0.2585 0.8171
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0037 0.0269
Mycobacterium ulcerans short-chain type oxidoreductase 0.0013 0.0037 0.0064
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0252 0.3164 0.3164
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0136 0.0416
Loa Loa (eye worm) heat shock protein 75 0.0034 0.0316 0.0337
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0119 0.1573
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Echinococcus granulosus FTZ F1 alpha 0.0252 0.3164 0.3164
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0406 0.519 0.519
Plasmodium falciparum heat shock protein 90, putative 0.0195 0.2419 1
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0021 0.0083
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Onchocerca volvulus 0.0017 0.0095 0.03
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.004
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0119 0.1424 0.1424
Onchocerca volvulus Sepiapterin reductase homolog 0.0013 0.0037 0.0118
Trypanosoma brucei short-chain dehydrogenase, putative 0.0013 0.0037 0.0144
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0013 0.0037 0.0064
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0214
Loa Loa (eye worm) hypothetical protein 0.0119 0.1424 0.1518
Loa Loa (eye worm) hypothetical protein 0.0133 0.161 0.1717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0095 0.1193
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Trypanosoma cruzi metacaspase, putative 0.0019 0.0119 0.1573
Loa Loa (eye worm) CYP4Cod1 0.0042 0.0417 0.0445
Loa Loa (eye worm) ctsf protein 0.0017 0.0095 0.0101
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0095 0.0101
Loa Loa (eye worm) hypothetical protein 0.0119 0.1424 0.1518
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0119 0.0492
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0252 0.3164 0.3164
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0013 0.0037 0.0064
Brugia malayi nuclear receptor NHR-88 0.0252 0.3164 0.3374
Brugia malayi Cytochrome P450 family protein 0.0042 0.0417 0.0445
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0022
Echinococcus granulosus smad 0.0018 0.0104 0.0104
Onchocerca volvulus 0.0012 0.0021 0.0065
Loa Loa (eye worm) heat shock protein 90 0.0051 0.0542 0.0578
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0252 0.3164 0.3374
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.0154
Loa Loa (eye worm) hypothetical protein 0.0063 0.0701 0.0747
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0012 0.0025 0.0025
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0013 0.0037 0.0438
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0277
Loa Loa (eye worm) hypothetical protein 0.0119 0.1424 0.1518
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0799 0.0799
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0013 0.0037 0.0152
Brugia malayi Cathepsin L-like precursor 0.0017 0.0095 0.0101
Brugia malayi tailless protein 0.0119 0.1424 0.1518
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Echinococcus granulosus heat shock protein 90 0.0044 0.0445 0.0445
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0082 0.0087
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Echinococcus multilocularis 0.0012 0.0027 0.0027
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0095 0.0242
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0034 0.0316 0.0316
Echinococcus multilocularis smad 0.0018 0.0104 0.0104
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0134 0.1618 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0119 0.1424 0.1424
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0019 0.0119 0.0119
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0042 0.0417 0.2453
Loa Loa (eye worm) nuclear hormone receptor 0.0119 0.1424 0.1518
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0095 0.1193
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0048 0.0501 0.2978
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0061 0.0061
Trypanosoma brucei cytochrome P450, putative 0.0042 0.0417 0.5563
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0013 0.0037 0.0037
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0095 0.039
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0081 0.0081
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0195 0.2427 0.2427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0252 0.3164 0.3374
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Leishmania major quinonoid dihydropteridine reductase 0.0013 0.0037 0.0064
Trypanosoma brucei heat shock protein 84, putative 0.0034 0.0316 0.4123
Onchocerca volvulus 0.003 0.0265 0.0839
Leishmania major heat shock protein, putative 0.0034 0.0316 0.1818
Loa Loa (eye worm) hypothetical protein 0.0044 0.0451 0.0481
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.1618 1
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0799 0.0799
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0037 0.0037
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0151 0.2013
Schistosoma mansoni heat shock protein 0.0051 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0119 0.1424 0.1518
Onchocerca volvulus 0.0044 0.0451 0.1426
Onchocerca volvulus 0.0252 0.3164 1
Trypanosoma cruzi metacaspase, putative 0.0019 0.0119 0.1573
Trypanosoma brucei protein kinase, putative 0.0059 0.0645 0.8811
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0095 0.1193
Schistosoma mansoni coup transcription factor 0.0252 0.3164 0.3164
Trypanosoma brucei heat shock protein, putative 0.0051 0.0542 0.7342
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0136 0.1856
Schistosoma mansoni RAR-like nuclear receptor 0.0252 0.3164 0.3164
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0095 0.1193
Onchocerca volvulus 0.0013 0.0037 0.0118
Trypanosoma cruzi short chain dehydrogenase, putative 0.0013 0.0037 0.0438
Brugia malayi dehydrogenases, short chain protein 2 0.0013 0.0037 0.004
Echinococcus granulosus thyroid hormone receptor alpha 0.0119 0.1424 0.1424
Schistosoma mansoni steroid hormone receptor ad4bp 0.0252 0.3164 0.3164
Brugia malayi ecdysone receptor 0.0119 0.1424 0.1518
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0095 0.1193
Entamoeba histolytica hypothetical protein, conserved 0.0013 0.0037 0.0152
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0095 0.0101
Brugia malayi heat shock protein 90 0.0051 0.0542 0.0578
Loa Loa (eye worm) RecQ helicase 0.002 0.0136 0.0146
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0252 0.3164 0.3164
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0119 0.1424 0.1424
Toxoplasma gondii aldehyde dehydrogenase 0.0134 0.1618 0.6689
Schistosoma mansoni hypothetical protein 0.0044 0.0451 0.0451
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0095 0.039
Loa Loa (eye worm) hypothetical protein 0.0252 0.3164 0.3374
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0037 0.0037
Trypanosoma cruzi Heat shock protein 83, putative 0.0051 0.0542 0.7421
Echinococcus multilocularis steroid dehydrogenase 0.0013 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0095 0.1193
Leishmania major cathepsin L-like protease 0.0066 0.0729 0.441
Onchocerca volvulus 0.0013 0.0037 0.0118
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0013 0.0037 0.0214
Brugia malayi MAP kinase sur-1 0.0059 0.0645 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0252 0.3164 0.3374
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0252 0.3164 0.3374
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0013 0.0037 0.0438
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.0154
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Schistosoma mansoni smad1 5 8 and 0.0018 0.0104 0.0104
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0729 1
Schistosoma mansoni nuclear receptor nhr-48 0.0119 0.1424 0.1424
Toxoplasma gondii oxidoreductase, putative 0.0013 0.0037 0.0154
Leishmania major cathepsin L-like protease 0.0017 0.0095 0.0427
Mycobacterium ulcerans dehydrogenase 0.0013 0.0037 0.0064
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0081 0.0086
Onchocerca volvulus 0.0013 0.0037 0.0118
Trypanosoma brucei short-chain dehydrogenase, putative 0.0013 0.0037 0.0144
Brugia malayi nuclear receptor RXR 0.0133 0.161 0.1717
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Loa Loa (eye worm) dehydrogenase 0.0013 0.0037 0.004
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Schistosoma mansoni transcription factor LCR-F1 0.0195 0.2427 0.2427
Echinococcus granulosus jun protein 0.0091 0.106 0.106
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0119 0.1424 0.1424
Leishmania major dehydrogenase-like protein 0.0013 0.0037 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0252 0.3164 0.3374
Entamoeba histolytica hypothetical protein 0.0013 0.0037 0.0152
Loa Loa (eye worm) cytochrome P450 0.0012 0.0027 0.0029
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0224 0.2808 0.2808
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0252 0.3164 0.3164
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0469 0.0469
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0252 0.3164 0.3164
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0119 0.1582
Loa Loa (eye worm) oxidoreductase 0.0013 0.0037 0.004
Echinococcus multilocularis caspase 0.0019 0.0119 0.0119
Echinococcus granulosus nuclear receptor nhr 48 0.0119 0.1424 0.1424
Schistosoma mansoni hypothetical protein 0.0562 0.7229 0.7229
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0091 0.106 0.106
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0012 0.0025 0.0025
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0391 0.5927
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Mycobacterium ulcerans heat shock protein 90 0.0048 0.0501 0.2978
Mycobacterium ulcerans short-chain dehydrogenase 0.0013 0.0037 0.0064
Trypanosoma brucei short-chain dehydrogenase, putative 0.0013 0.0037 0.0144
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0417 0.0445
Brugia malayi Cathepsin L-like precursor 0.0012 0.0021 0.0022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Mycobacterium ulcerans short-chain dehydrogenase 0.0013 0.0037 0.0064
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0082 0.0082
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0252 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0133 0.161 0.1717
Echinococcus granulosus oxidoreductase 0.0013 0.0037 0.0037
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0114 0.1368 0.1368
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0136 0.0564
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0726 0.9377 1
Echinococcus multilocularis heat shock protein 90 0.0051 0.0542 0.0542
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0119 0.0493
Trypanosoma cruzi metacaspase, putative 0.0019 0.0119 0.1573
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0799 0.0853
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0136 0.0136
Schistosoma mansoni hypothetical protein 0.0053 0.0563 0.0563
Echinococcus multilocularis retinol dehydrogenase 13 0.0013 0.0037 0.0037
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0081 0.0081
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0391 0.5927
Brugia malayi Retinol dehydrogenase 12 0.0013 0.0037 0.004
Echinococcus multilocularis caspase 8 0.0019 0.0119 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0729 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0119 0.1424 0.1424
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0013 0.0037 0.0152
Plasmodium vivax endoplasmin, putative 0.0051 0.0542 0.224
Echinococcus granulosus cathepsin l1 0.0017 0.0095 0.0095
Leishmania major quinonoid dihydropteridine reductase 0.0013 0.0037 0.0064
Onchocerca volvulus 0.0013 0.0037 0.0118
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0729 1
Loa Loa (eye worm) hypothetical protein 0.0252 0.3164 0.3374
Echinococcus granulosus nuclear factor of activated T cells 5 0.0083 0.0951 0.0951
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0095 0.1193
Leishmania major quinonoid dihydropteridine reductase 0.0013 0.0037 0.0064
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0095 0.1193
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0339 0.4306 0.4592
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0013 0.0037 0.0037
Loa Loa (eye worm) oxidoreductase 0.0013 0.0037 0.004
Brugia malayi Cathepsin L-like precursor 0.0017 0.0095 0.0101
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.004
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0013 0.0037 0.0154
Treponema pallidum heat shock protein 90 0.0048 0.0501 1
Schistosoma mansoni netrin receptor unc5 0.0016 0.0081 0.0081
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0136 0.0146
Echinococcus granulosus hypothetical protein 0.0013 0.0037 0.0037
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0799 0.0853
Loa Loa (eye worm) RNA binding protein 0.0071 0.0799 0.0853
Brugia malayi oxidoreductase 0.0013 0.0037 0.004
Mycobacterium ulcerans short-chain dehydrogenase 0.0013 0.0037 0.0064
Leishmania major quinonoid dihydropteridine reductase 0.0013 0.0037 0.0064
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0013 0.0037 0.0037
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0013 0.0037 0.0064
Brugia malayi Endoplasmin precursor 0.0051 0.0542 0.0578
Trichomonas vaginalis heat shock protein, putative 0.003 0.0261 0.3843
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0729 1
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0729 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0119 0.1582
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0013 0.0037 0.0144
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0013 0.0037 0.004
Echinococcus granulosus cathepsin l1 0.0012 0.0021 0.0021
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0134 0.1618 0.1618
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0075
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0012 0.0025 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0037 0.0438
Entamoeba histolytica hypothetical protein 0.0195 0.2427 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0012 0.0025 0.0027
Onchocerca volvulus Bile acid receptor homolog 0.0252 0.3164 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0563 0.0563
Echinococcus multilocularis lamin 0.003 0.0265 0.0265
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0133 0.161 0.1717
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.0424 0.0452
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0013 0.0037 0.0269
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0645 0.0645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0095 0.1193
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0013 0.0037 0.0438
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0252 0.3164 0.3374
Trypanosoma brucei metacaspase 0.0019 0.0119 0.1313
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0095 0.0095
Brugia malayi Uncoordinated protein 44 0.0016 0.0081 0.0086
Loa Loa (eye worm) endoplasmin 0.0051 0.0542 0.0578
Mycobacterium leprae Probable oxidoreductase 0.0013 0.0037 0.0214
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0013 0.0037 0.0438
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0013 0.0037 0.0438
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0799 0.0799
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Echinococcus multilocularis GPCR, family 2 0.0053 0.0563 0.0563
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0016 0.0082 0.0088
Brugia malayi MH1 domain containing protein 0.0018 0.0104 0.0111
Trypanosoma brucei heat shock protein, putative 0.0051 0.0542 0.7342
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0006
Echinococcus multilocularis heat shock protein 90 0.0044 0.0445 0.0445
Brugia malayi Smad1 0.0018 0.0104 0.0111
Brugia malayi hypothetical protein 0.0044 0.0451 0.0481
Brugia malayi hypothetical protein 0.0013 0.0037 0.004
Leishmania major cathepsin L-like protease 0.0017 0.0095 0.0427
Echinococcus multilocularis oxidoreductase 0.0013 0.0037 0.0037
Echinococcus granulosus carbonyl reductase 1 0.0013 0.0037 0.0037
Leishmania major pteridine reductase 1 0.0013 0.0037 0.0064
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0013 0.0037 0.0064
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Leishmania major hypothetical protein, conserved 0.0013 0.0037 0.0064
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0146
Leishmania major 3-keto-dihydrosphingosine reductase 0.0013 0.0037 0.0064
Trichomonas vaginalis heat shock protein, putative 0.0048 0.0501 0.7689
Loa Loa (eye worm) hypothetical protein 0.003 0.0258 0.0275
Trypanosoma brucei metacaspase MCA3 0.0019 0.0119 0.1313
Mycobacterium tuberculosis Probable dehydrogenase 0.0013 0.0037 0.0064
Loa Loa (eye worm) hypothetical protein 0.0119 0.1424 0.1518
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0645 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0119 0.1424 0.1518
Echinococcus multilocularis geminin 0.0562 0.7229 0.7229
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0095 0.1193
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0167 0.2061 0.2198
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0037 0.0438
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0417 0.5696
Entamoeba histolytica hypothetical protein 0.0195 0.2427 1
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Trypanosoma brucei Heat shock protein 83, putative 0.0051 0.0542 0.7342
Brugia malayi hypothetical protein 0.0071 0.0804 0.0858
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0104 0.0111
Loa Loa (eye worm) hypothetical protein 0.0252 0.3164 0.3374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0095 0.1193
Loa Loa (eye worm) hypothetical protein 0.0648 0.8349 0.8903
Brugia malayi Calcitonin receptor-like protein seb-1 0.0167 0.2061 0.2198
Echinococcus granulosus heat shock protein 90 0.0051 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.004
Trichomonas vaginalis steroid dehydrogenase, putative 0.0013 0.0037 0.0269
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0095 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0252 0.3164 0.3374
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0136 0.1558
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0013 0.0037 0.0064
Plasmodium falciparum endoplasmin, putative 0.0037 0.0358 0.1346
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.0424 0.0452
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0037 0.0037
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0136 0.0146
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0071 0.0071
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0134 0.1618 1
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0265 0.0283
Schistosoma mansoni cytochrome P450 0.0012 0.0027 0.0027
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Echinococcus granulosus hypothetical protein 0.0013 0.0037 0.0037
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.0037 0.0037
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0252 0.3164 0.3374
Brugia malayi nuclear hormone receptor family member odr-7 0.0119 0.1424 0.1518
Echinococcus granulosus carbonyl reductase 1 0.0013 0.0037 0.0037
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0048 0.0501 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0252 0.3164 1
Brugia malayi MH2 domain containing protein 0.0018 0.0104 0.0111
Brugia malayi small heat shock protein 0.0648 0.8349 0.8903
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0013 0.0037 0.0064
Brugia malayi Death domain containing protein 0.0016 0.0081 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0037 0.0438
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0095 0.0242
Schistosoma mansoni thyroid hormone receptor 0.0658 0.8485 0.8485
Mycobacterium ulcerans short-chain dehydrogenase 0.0013 0.0037 0.0064
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0119 0.1424 0.1424
Schistosoma mansoni intermediate filament proteins 0.003 0.0265 0.0265
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0013 0.0037 0.0037
Schistosoma mansoni lamin 0.003 0.0265 0.0265
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0799 0.0799
Onchocerca volvulus 0.0013 0.0037 0.0118
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0012 0.0025 0.0025
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0136 0.0146
Trypanosoma brucei heat shock protein 90, putative 0.0051 0.0542 0.7342
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0013 0.0037 0.0152
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0252 0.3164 0.3374
Mycobacterium ulcerans oxidoreductase 0.0013 0.0037 0.0064
Loa Loa (eye worm) oxidoreductase 0.0013 0.0037 0.004
Schistosoma mansoni thyroid hormone receptor 0.0658 0.8485 0.8485
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Loa Loa (eye worm) hypothetical protein 0.0119 0.1424 0.1518
Schistosoma mansoni DNA helicase recq1 0.002 0.0136 0.0136
Loa Loa (eye worm) oxidoreductase 0.0013 0.0037 0.004
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0104 0.0104
Echinococcus granulosus endoplasmin 0.0048 0.0501 0.0501
Schistosoma mansoni nuclear hormone receptor 0.0252 0.3164 0.3164
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Echinococcus multilocularis microtubule associated protein 2 0.0774 1 1
Entamoeba histolytica recQ family helicase, putative 0.002 0.0136 0.0561
Loa Loa (eye worm) hypothetical protein 0.0119 0.1424 0.1518
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Loa Loa (eye worm) hypothetical protein 0.0033 0.0301 0.0321
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0224 0.2808 0.2808
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0013 0.0037 0.0438
Loa Loa (eye worm) hypothetical protein 0.0119 0.1424 0.1518
Plasmodium vivax steroid dehydrogenase, putative 0.0013 0.0037 0.0152
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0013 0.0037 0.0154
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0563 0.0563
Echinococcus granulosus hyperpolarization activated cyclic 0.0012 0.0025 0.0025
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0104 0.0104
Schistosoma mansoni carbonyl reductase 0.0013 0.0037 0.0037
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0013 0.0037 0.0438
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0252 0.3164 0.3374
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0417 0.0445
Loa Loa (eye worm) hypothetical protein 0.0016 0.0081 0.0086
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0013 0.0037 0.0037
Echinococcus granulosus carbonyl reductase 1 0.0013 0.0037 0.0037
Echinococcus multilocularis hyperpolarization activated cyclic 0.0012 0.0025 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0729 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0012 0.0025 0.0027
Entamoeba histolytica recQ family DNA helicase 0.001 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0114 0.1368 0.1458
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0022
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0095 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0119 0.1582
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0645 0.8846
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0119 0.1424 0.4499
Echinococcus granulosus caspase 8 0.0019 0.0119 0.0119
Echinococcus granulosus apoptotic protease activating factor 1 0.0044 0.0451 0.0451
Brugia malayi cytochrome P450 0.0012 0.0027 0.0029
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0104 0.0111
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.004
Onchocerca volvulus 0.0017 0.0095 0.03
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0119 0.1582
Brugia malayi MH2 domain containing protein 0.0018 0.0104 0.0111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0095 0.1193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0095 0.1193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0729 1
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0563 0.06
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0136 0.0416
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0136 0.0687
Brugia malayi Hsp90 protein 0.0034 0.0316 0.0337
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Echinococcus multilocularis ecdysone induced protein 78C 0.0252 0.3164 0.3164
Schistosoma mansoni endoplasmin 0.0051 0.0542 0.0542
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0013 0.0037 0.0064
Schistosoma mansoni caspase-3 (C14 family) 0.0019 0.0119 0.0119
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0037 0.0064
Leishmania major cathepsin L-like protease 0.0017 0.0095 0.0427
Trypanosoma brucei heat shock protein, putative 0.0051 0.0542 0.7342
Loa Loa (eye worm) hypothetical protein 0.0252 0.3164 0.3374
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0799 0.0853
Echinococcus multilocularis conserved hypothetical protein 0.0013 0.0037 0.0037
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0037 0.0269
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Brugia malayi hypothetical protein 0.0102 0.1211 0.1292
Brugia malayi hypothetical protein 0.0133 0.161 0.1717
Loa Loa (eye worm) hypothetical protein 0.0053 0.0563 0.06
Giardia lamblia Grp94/Hsp90 0.0048 0.0501 0.7625
Leishmania major short chain dehydrogenase, putative 0.0013 0.0037 0.0064
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0012 0.0024 0.0024
Plasmodium vivax heat shock protein 86, putative 0.0051 0.0542 0.224
Trypanosoma brucei short-chain dehydrogenase, putative 0.0013 0.0037 0.0144
Toxoplasma gondii carbonyl reductase 1, putative 0.0013 0.0037 0.0154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0729 1
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0037 0.0037
Leishmania major heat shock protein 83-1 0.0051 0.0542 0.3237
Trypanosoma brucei oxidoreductase-like protein 0.0013 0.0037 0.0144
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0134 0.1618 0.1618
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0081 0.0081
Schistosoma mansoni nuclear receptor 0.0119 0.1424 0.1424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0095 0.1193
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.1618 1
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0095 0.1237
Schistosoma mansoni hypothetical protein 0.0562 0.7229 0.7229
Entamoeba histolytica cysteine protease, putative 0.0017 0.0095 0.039
Leishmania major short chain dehydrogenase, putative 0.0013 0.0037 0.0064
Loa Loa (eye worm) hypothetical protein 0.0133 0.161 0.1717
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0037 0.0438
Echinococcus granulosus steroid dehydrogenase 0.0013 0.0037 0.0037
Echinococcus multilocularis hyperpolarization activated cyclic 0.0012 0.0025 0.0025
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Brugia malayi nuclear hormone receptor 0.0252 0.3164 0.3374
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0119 0.0493
Trypanosoma cruzi heat shock protein, putative 0.0034 0.0316 0.4299
Leishmania major hypothetical protein, conserved 0.0013 0.0037 0.0064
Loa Loa (eye worm) hypothetical protein 0.0119 0.1424 0.1518
Echinococcus multilocularis bloom syndrome protein 0.002 0.0136 0.0136
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0136 0.1856
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0095 0.0427
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.0424 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0119 0.1582
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0654 0.8969
Echinococcus granulosus ecdysone induced protein 78C 0.0252 0.3164 0.3164
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0025 0.0025
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0013 0.0037 0.004
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0013 0.0037 0.004
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0037 0.0269
Mycobacterium tuberculosis Probable oxidoreductase 0.0013 0.0037 0.0064
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0095 0.1193
Trypanosoma cruzi metacaspase, putative 0.0019 0.0119 0.1573
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0013 0.0037 0.0214
Onchocerca volvulus 0.0017 0.0095 0.03
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0064
Brugia malayi Cell death protein 3 precursor 0.0063 0.0701 0.0747
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0095 0.0095
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0136 0.0146
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0037 0.004
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0252 0.3164 0.3164
Trypanosoma brucei metacaspase MCA2 0.0019 0.0119 0.1313
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.0037 0.0037

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 4.65 ug ml-1 Cytotoxicity against human NCI-H187 cells ChEMBL. 18179177
IC50 (functional) = 4.65 ug ml-1 Cytotoxicity against human NCI-H187 cells ChEMBL. 18179177
IC50 (functional) = 7.08 ug ml-1 Cytotoxicity against human breast cancer cells ChEMBL. 18179177
MIC (functional) = 3.13 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Ra by microplate alamar blue assay ChEMBL. 18179177
MIC (functional) = 3.13 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Ra by microplate alamar blue assay ChEMBL. 18179177

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 18179177

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.