Detailed information for compound 619517

Basic information

Technical information
  • TDR Targets ID: 619517
  • Name: 1-(3-tert-butyl-2,4,5,6,7,8-hexahydro-[1]benz othiolo[3,2-e]pyrimidin-1-yl)ethanone
  • MW: 292.44 | Formula: C16H24N2OS
  • H donors: 0 H acceptors: 1 LogP: 3.22 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)N1CN(Cc2c1sc1c2CCCC1)C(C)(C)C
  • InChi: 1S/C16H24N2OS/c1-11(19)18-10-17(16(2,3)4)9-13-12-7-5-6-8-14(12)20-15(13)18/h5-10H2,1-4H3
  • InChiKey: JQHUKLZBTQPROS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-tert-butyl-2,4,5,6,7,8-hexahydrobenzothiopheno[3,2-e]pyrimidin-1-yl)ethanone
  • T5472872

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0024 0.0027 0.0044
Mycobacterium tuberculosis Probable aminotransferase 0.015 0.0443 0.0812
Schistosoma mansoni hypothetical protein 0.0042 0.0086 0.0086
Trichomonas vaginalis set domain proteins, putative 0.0986 0.3216 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0043 0.0043
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0127 0.0366 0.0366
Mycobacterium tuberculosis Conserved protein 0.0258 0.0803 0.1477
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0036
Leishmania major mitochondrial DNA polymerase beta 0.0317 0.0998 0.7107
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0028 0.0278
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0024 0.0027 0.0027
Mycobacterium leprae Conserved hypothetical protein 0.0042 0.0085 0.0856
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0042 0.0085 0.058
Schistosoma mansoni zinc finger protein 0.0029 0.0043 0.0043
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0258 0.0803 0.0803
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0261 0.0813 1
Trichomonas vaginalis conserved hypothetical protein 0.0261 0.0813 0.253
Onchocerca volvulus 0.0101 0.0281 0.0874
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0014 0.0042
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0109 0.031 0.2207
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.002 0.0013 0.0013
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0317 0.0998 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0014 0.0014
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0066 0.0658
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0042 0.0085 0.058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.0151 0.0151
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0127 0.0366 0.0366
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0042 0.0085 0.058
Echinococcus granulosus microtubule associated protein 2 0.1434 0.47 0.47
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0042 0.0085 0.015
Leishmania major hypothetical protein, conserved 0.0104 0.029 0.2068
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0043 0.0135
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0261 0.0813 0.0813
Schistosoma mansoni aldehyde dehydrogenase 0.0024 0.0027 0.0027
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.015 0.0443 0.314
Treponema pallidum gamma-glutamyl phosphate reductase 0.0024 0.0027 0.0292
Loa Loa (eye worm) hypothetical protein 0.0258 0.0803 0.0803
Schistosoma mansoni ap endonuclease 0.0059 0.0144 0.0144
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0004 0.0011
Echinococcus multilocularis muscleblind protein 1 0.1373 0.4497 0.4497
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0026
Echinococcus multilocularis ubiquitin specific protease 41 0.0198 0.0602 0.0602
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0024 0.0027 0.0274
Brugia malayi hypothetical protein 0.0299 0.0937 0.0937
Echinococcus granulosus o acyltransferase membrane bound domain 0.0261 0.0813 0.0813
Mycobacterium tuberculosis Probable lipase LipE 0.0258 0.0803 0.1477
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0043 0.0043
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0066 0.4421
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0041 0.0082 0.0082
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0024 0.0027 0.0194
Onchocerca volvulus 0.0029 0.0043 0.0135
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0261 0.0813 0.868
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0036
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.0151 0.0151
Brugia malayi Inositol-1 0.0036 0.0066 0.0066
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0034 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0198 0.0602 0.1872
Loa Loa (eye worm) hypothetical protein 0.0033 0.0055 0.0055
Plasmodium falciparum histone acetyltransferase GCN5 0.0083 0.0223 0.2737
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.1009 0.1009
Brugia malayi MBOAT family protein 0.0261 0.0813 0.0813
Plasmodium vivax glutathione reductase, putative 0.0049 0.011 0.1354
Brugia malayi glutathione reductase 0.0049 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.002 0.0013 0.0013
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0042 0.0085 0.058
Mycobacterium ulcerans aldehyde dehydrogenase 0.044 0.1404 1
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0024 0.0027 0.0169
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0042 0.0085 0.058
Leishmania major GTP-binding protein, putative 0.0022 0.002 0.0145
Leishmania major hypothetical protein, conserved 0.0261 0.0813 0.5793
Brugia malayi Muscleblind-like protein 0.1373 0.4497 0.4497
Brugia malayi nuclear receptor NHR-88 0.0029 0.0043 0.0043
Loa Loa (eye worm) MBOAT family protein 0.0261 0.0813 0.0813
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0198 0.0602 0.6032
Giardia lamblia Histone acetyltransferase GCN5 0.0083 0.0223 0.3699
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Entamoeba histolytica hypothetical protein 0.0299 0.0937 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0164 0.0489 0.0489
Onchocerca volvulus Huntingtin homolog 0.0131 0.0381 0.1184
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0034 0.0034
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.029 0.291
Entamoeba histolytica hypothetical protein 0.0024 0.0028 0.0296
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0261 0.0813 0.0813
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0024 0.0027 0.0027
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.002 0.0013 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0042 0.0085 0.015
Schistosoma mansoni hypothetical protein 0.0046 0.0101 0.0101
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0024 0.0027 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0151 0.0151
Echinococcus multilocularis lamin dm0 0.0026 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0299 0.0937 0.0937
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0028 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0014 0.0137
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.002 0.0013 0.0013
Trichomonas vaginalis penicillin-binding protein, putative 0.0258 0.0803 0.2498
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0042 0.0085 0.015
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0024 0.0027 0.0291
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0151 0.0151
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0308 0.0969 0.0969
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0261 0.0813 0.0813
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0042 0.0085 0.015
Echinococcus multilocularis muscleblind protein 0.1373 0.4497 0.4497
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0024 0.0027 0.0027
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0014 0.0072
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0198 0.0602 0.0602
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0001 0.0001
Echinococcus multilocularis mitogen activated protein kinase 0.0109 0.031 0.031
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0464 0.1486 0.1486
Brugia malayi Cytochrome P450 family protein 0.006 0.0147 0.0147
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0117 0.0117
Schistosoma mansoni microtubule-associated protein tau 0.1434 0.47 0.47
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0042 0.0085 0.058
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.0998 1
Toxoplasma gondii ABC1 family protein 0.0258 0.0803 0.5719
Schistosoma mansoni cpg binding protein 0.0117 0.0333 0.0333
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0261 0.0813 0.868
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0117 0.0117
Toxoplasma gondii aldehyde dehydrogenase 0.044 0.1404 1
Treponema pallidum alginate O-acetylation protein (algI) 0.0261 0.0813 1
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0261 0.0813 0.0813
Schistosoma mansoni polycystin 1-related 0.0042 0.0086 0.0086
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0198 0.0602 0.0602
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0014 0.0137
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0035 0.0108
Loa Loa (eye worm) hypothetical protein 0.0258 0.0803 0.0803
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0042 0.0085 0.085
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0018 0.0018
Mycobacterium ulcerans L-lysine aminotransferase 0.0021 0.0018 0.01
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.002 0.0013 0.0041
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0047 0.0331
Brugia malayi Hhat protein 0.0261 0.0813 0.0813
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0261 0.0813 0.0813
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0053 0.0092
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.0018 0.01
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.002 0.0013 0.0013
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0043 0.0043
Brugia malayi photoreceptor-specific nuclear receptor 0.0062 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0014 0.0019
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.002 0.002
Onchocerca volvulus 0.0042 0.0086 0.0268
Leishmania major DNA polymerase kappa, putative 0.002 0.0014 0.0097
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0021 0.0018 0.01
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.011 0.0197
Brugia malayi MAP kinase sur-1 0.0109 0.031 0.031
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0034 0.0058 0.0058
Toxoplasma gondii exonuclease III APE 0.0059 0.0144 0.1025
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0261 0.0813 0.0813
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0024 0.0027 0.0027
Brugia malayi MBOAT family protein 0.0261 0.0813 0.0813
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0028 0.0086
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0042 0.0085 0.015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0151 0.0151
Mycobacterium leprae Probable lipase LipE 0.0258 0.0803 1
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.031 0.031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0144 0.1442
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0042 0.0085 0.085
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0014 0.0014
Mycobacterium tuberculosis Conserved protein 0.0258 0.0803 0.1477
Trypanosoma brucei glycerol uptake protein, putative 0.0261 0.0813 0.8151
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0014 0.0137
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.032 0.1009 0.1009
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0144 0.1769
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0042 0.0085 0.058
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0042 0.0085 0.058
Loa Loa (eye worm) MBOAT family protein 0.0261 0.0813 0.0813
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.002 0.0013 0.0013
Brugia malayi steroid hormone receptor 0.0062 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0093 0.0256 0.0256
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0014 0.0137
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0198 0.0602 0.1872
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0004 0.0044
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.002 0.0013 0.0013
Echinococcus granulosus neuropeptide receptor A26 0.0523 0.1679 0.1679
Mycobacterium ulcerans lipase LipD 0.0258 0.0803 0.5708
Plasmodium vivax ataxin-2 like protein, putative 0.0104 0.029 0.357
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0042 0.0085 0.058
Brugia malayi Pre-SET motif family protein 0.0127 0.0366 0.0366
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0042 0.0085 0.058
Schistosoma mansoni peptidase 0.0017 0.0003 0.0003
Schistosoma mansoni intermediate filament proteins 0.0026 0.0034 0.0034
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.015 0.0443 0.1379
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0261 0.0813 0.0813
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.0151 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0127 0.0366 0.0366
Loa Loa (eye worm) hhat protein 0.0261 0.0813 0.0813
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0001 0.0001
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0024 0.0027 0.0291
Loa Loa (eye worm) hypothetical protein 0.0062 0.0151 0.0151
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0186 0.0565 0.0565
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0144 0.1442
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.031 0.0964
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0055 0.0055
Mycobacterium ulcerans acetylornithine aminotransferase 0.0021 0.0018 0.01
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0261 0.0813 0.5793
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0299 0.0937 0.0937
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0108
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0198 0.0602 1
Echinococcus granulosus mitogen activated protein kinase 0.0109 0.031 0.031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0036
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0024 0.0027 0.0027
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0024 0.0027 0.0027
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0043 0.0043
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.044 0.1404 0.1404
Loa Loa (eye worm) histone methyltransferase 0.0041 0.0082 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0464 0.1486 0.1486
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0198 0.0602 0.0602
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0001 0.0001
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0261 0.0813 0.0813
Schistosoma mansoni aldehyde dehydrogenase 0.0024 0.0027 0.0027
Echinococcus granulosus importin subunit beta 1 0.003 0.0047 0.0047
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0042 0.0085 0.058
Echinococcus multilocularis thyroid hormone receptor alpha 0.0062 0.0151 0.0151
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0018 0.0018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0258 0.0803 0.1477
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0001 0.0001
Brugia malayi aldehyde dehydrogenase 0.0024 0.0027 0.0027
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0004 0.0044
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.0151 0.0471
Echinococcus multilocularis RUN 0.0042 0.0086 0.0086
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0014 0.0137
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0004
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0021 0.0018 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0042 0.0085 0.015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0035 0.0108
Echinococcus multilocularis snurportin 1 0.032 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0033 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0299 0.0937 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0086 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0464 0.1486 0.1486
Trichomonas vaginalis conserved hypothetical protein 0.0261 0.0813 0.253
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0024 0.0027 0.0194
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0198 0.0602 0.4287
Brugia malayi nuclear receptor NHR-88 0.0062 0.0151 0.0151
Schistosoma mansoni cytochrome P450 0.0042 0.0085 0.0085
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.031 0.0964
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.002 0.0013 0.0013
Trypanosoma brucei hypothetical protein, conserved 0.0258 0.0803 0.8048
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0042 0.0085 0.015
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0042 0.0085 0.058
Trichomonas vaginalis bromodomain-containing protein, putative 0.0091 0.0248 0.077
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0042 0.0085 0.058
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0024 0.0027 0.0169
Echinococcus granulosus histone lysine methyltransferase setb 0.0127 0.0366 0.0366
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0014 0.0146
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0151 0.0151
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0004 0.0036
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0024 0.0027 0.0123
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.0151 0.0151
Schistosoma mansoni nuclear receptor 0.0029 0.0043 0.0043
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.3033 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0151 0.0151
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0004 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0043 0.0043
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0024 0.0027 0.0027
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0042 0.0085 0.058
Trypanosoma cruzi cytochrome P450, putative 0.006 0.0147 0.1478
Loa Loa (eye worm) hhat protein 0.0261 0.0813 0.0813
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0151 0.0151
Brugia malayi hypothetical protein 0.0104 0.029 0.029
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0261 0.0813 0.868
Schistosoma mansoni ran 0.0022 0.002 0.002
Onchocerca volvulus 0.0026 0.0034 0.0105
Entamoeba histolytica hypothetical protein 0.0299 0.0937 1
Schistosoma mansoni ap endonuclease 0.0059 0.0144 0.0144
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0144 0.1025
Toxoplasma gondii histone lysine methyltransferase SET1 0.0233 0.0719 0.5121
Onchocerca volvulus 0.0029 0.0043 0.0135
Echinococcus granulosus o acyltransferase membrane bound domain 0.0261 0.0813 0.0813
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0464 0.1486 0.1486
Entamoeba histolytica acetyltransferase, GNAT family 0.0083 0.0223 0.2376
Onchocerca volvulus 0.0104 0.0291 0.0906
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.002 0.0013 0.0013
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0066 0.0066
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.0775 0.0775
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0109 0.031 0.2207
Brugia malayi cytochrome P450 0.0042 0.0085 0.0085
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0252 0.0782 0.0782
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0042 0.0085 0.058
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.002 0.0013 0.0013
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0014 0.0072
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0014 0.0014
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0086 0.1059
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.002 0.0013 0.0013
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0024 0.0027 0.0044
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0109 0.031 0.3105
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0024 0.0027 0.0291
Toxoplasma gondii hypothetical protein 0.0261 0.0813 0.5793
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0004 0.0004
Leishmania major aldehyde dehydrogenase, putative 0.0024 0.0027 0.0194
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0004
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0043 0.0043
Schistosoma mansoni rab6-interacting 0.0042 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0258 0.0803 0.0803
Schistosoma mansoni inositol monophosphatase 0.0036 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.0151 0.0151
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0001 0.0001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0144 0.1535
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0127 0.1275
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0086 0.0086
Mycobacterium tuberculosis Conserved protein 0.0258 0.0803 0.1477
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0024 0.0027 0.0044
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.0151 0.0151
Echinococcus granulosus muscleblind protein 0.1373 0.4497 0.4497
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0004 0.0044
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0021 0.0018 0.0026
Brugia malayi Aldehyde dehydrogenase protein 4 0.0024 0.0027 0.0027
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0024 0.0027 0.0169
Trypanosoma cruzi GUP1, putative 0.0261 0.0813 0.8151
Trypanosoma cruzi glycerol uptake protein, putative 0.0261 0.0813 0.8151
Echinococcus multilocularis tumor protein p63 0.0709 0.2298 0.2298
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0024 0.0027 0.0194
Brugia malayi Cytochrome P450 family protein 0.006 0.0147 0.0147
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0062 0.0151 0.0151
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.044 0.1404 0.1404
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0055 0.0055
Trypanosoma cruzi cytochrome P450, putative 0.006 0.0147 0.1478
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.0151 0.0151
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.029 0.357
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.0151 0.0151
Onchocerca volvulus 0.002 0.0013 0.0041
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.011 0.011
Mycobacterium tuberculosis Probable hydrolase 0.0258 0.0803 0.1477
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0032
Schistosoma mansoni coup transcription factor 0.0062 0.0151 0.0151
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0119 0.0343 0.0343
Schistosoma mansoni GTP-binding protein alpha subunit 0.002 0.0013 0.0013
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.0203
Trichomonas vaginalis penicillin-binding protein, putative 0.0258 0.0803 0.2498
Echinococcus multilocularis importin subunit beta 1 0.003 0.0047 0.0047
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0151 0.0151
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0024 0.0027 0.0169
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0034 0.0034
Echinococcus multilocularis dna polymerase eta 0.002 0.0014 0.0014
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0261 0.0813 0.0813
Onchocerca volvulus 0.002 0.0013 0.0041
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0144 0.0259
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0198 0.0602 0.6032
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0014 0.0137
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0024 0.0027 0.0169
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0066 0.0467
Loa Loa (eye worm) hypothetical protein 0.1373 0.4497 0.4497
Loa Loa (eye worm) hypothetical protein 0.0024 0.0027 0.0027
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.002 0.0013 0.0041
Echinococcus multilocularis sterol O acyltransferase 1 0.0261 0.0813 0.0813
Loa Loa (eye worm) hypothetical protein 0.0198 0.0602 0.0602
Plasmodium falciparum glutathione reductase 0.0017 0.0004 0.0044
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0198 0.0602 0.0602
Plasmodium falciparum glutathione reductase 0.0049 0.011 0.1354
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0035 0.0108
Brugia malayi Pre-SET motif family protein 0.0867 0.282 0.282
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0144 0.1442
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0361 0.066
Schistosoma mansoni hypothetical protein 0.0261 0.0813 0.0813
Echinococcus multilocularis zinc finger protein 0.2772 0.9134 0.9134
Echinococcus granulosus mixed lineage leukemia protein mll 0.0034 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0042 0.0085 0.0085
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0014 0.0137
Echinococcus granulosus histone acetyltransferase KAT2B 0.0091 0.0248 0.0248
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0035 0.0108
Loa Loa (eye worm) hypothetical protein 0.0024 0.0027 0.0027
Brugia malayi G-protein alpha subunit 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0261 0.0813 0.0813
Mycobacterium ulcerans beta-lactamase 0.0258 0.0803 0.5708
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0464 0.1486 0.1486
Brugia malayi nuclear hormone receptor 0.0029 0.0043 0.0043
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0109 0.031 0.3105
Loa Loa (eye worm) glutathione reductase 0.0049 0.011 0.011
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0091 0.0248 0.1764
Echinococcus multilocularis dnaJ subfamily B 0.1253 0.4098 0.4098
Trypanosoma cruzi hypothetical protein, conserved 0.0258 0.0803 0.8048
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.0998 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0095 0.0951
Trypanosoma cruzi GUP1, putative 0.0261 0.0813 0.8151
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0093 0.0256 0.0256
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0043 0.0043
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0042 0.0085 0.0604
Entamoeba histolytica G protein alpha subunit, putative 0.002 0.0013 0.0141
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0091 0.0248 0.1764
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Brugia malayi tailless protein 0.0029 0.0043 0.0043
Echinococcus granulosus guanine nucleotide binding protein subunit 0.002 0.0013 0.0013
Echinococcus granulosus sterol O acyltransferase 1 0.0261 0.0813 0.0813
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0361 0.066
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0024 0.0027 0.0027
Toxoplasma gondii hypothetical protein 0.0051 0.0117 0.083
Giardia lamblia Alcohol dehydrogenase 0.0024 0.0027 0.0453
Leishmania major cytochrome p450-like protein 0.0042 0.0085 0.0604
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0258 0.0803 0.1477
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0117 0.0117
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0024 0.0027 0.0274
Onchocerca volvulus 0.0258 0.0803 0.2498
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.0281 0.0281
Leishmania major cytochrome p450-like protein 0.0042 0.0085 0.0604
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0024 0.0027 0.0027
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0319 0.0583
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0464 0.1486 0.1486
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0066 0.0658
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0042 0.0085 0.058
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0198 0.0602 0.0602
Echinococcus granulosus neuropeptide s receptor 0.0523 0.1679 0.1679
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0261 0.0813 0.0813
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0024 0.0027 0.0274
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0151 0.0151
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.002 0.0013 0.0013
Echinococcus multilocularis survival motor neuron protein 1 0.0494 0.1584 0.1584
Echinococcus granulosus guanine nucleotide binding protein G protein 0.002 0.0013 0.0013
Brugia malayi ecdysone receptor 0.0029 0.0043 0.0043
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.002 0.0013 0.0013
Brugia malayi hypothetical protein 0.0131 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) CYP4Cod1 0.006 0.0147 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0014 0.0137
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0261 0.0813 0.0813
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0024 0.0027 0.0274
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0198 0.0602 0.0602
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.002 0.0013 0.0013
Echinococcus multilocularis GPCR, family 2 0.0016 0.0001 0.0001
Loa Loa (eye worm) beta-lactamase 0.0258 0.0803 0.0803
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0021 0.0018 0.0018
Plasmodium falciparum ornithine aminotransferase 0.0021 0.0018 0.0217
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0014 0.0137
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0024 0.0027 0.0044
Schistosoma mansoni DNA polymerase eta 0.002 0.0014 0.0014
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.0151 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0108
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0043 0.0043
Leishmania major importin beta-1 subunit, putative 0.0024 0.0028 0.0198
Loa Loa (eye worm) hypothetical protein 0.0258 0.0803 0.0803
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.044 0.1404 0.2588
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0014 0.0137
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0261 0.0813 0.0813
Schistosoma mansoni lipoxygenase 0.0186 0.0565 0.0565
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Onchocerca volvulus 0.0042 0.0086 0.0268
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0366 0.0366
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0151 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.0151 0.0151
Echinococcus granulosus RUN 0.0042 0.0086 0.0086
Loa Loa (eye worm) DR-78 0.0029 0.0043 0.0043
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0004 0.006
Echinococcus granulosus cytochrome P450 2K1 0.0042 0.0085 0.0085
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.0151 0.0151
Echinococcus granulosus o acyltransferase membrane bound domain 0.0261 0.0813 0.0813
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0144 0.1769
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.002 0.0013 0.0013
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0024 0.0027 0.0194
Schistosoma mansoni transcription factor LCR-F1 0.0299 0.0937 0.0937
Echinococcus multilocularis lamin 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0494 0.1584 0.1584
Trichomonas vaginalis ran, putative 0.0022 0.002 0.0063
Brugia malayi hypothetical protein 0.002 0.0013 0.0013
Echinococcus granulosus snurportin 1 0.032 0.1009 0.1009
Loa Loa (eye worm) aldehyde dehydrogenase 0.0024 0.0027 0.0027
Toxoplasma gondii LsmAD domain-containing protein 0.0104 0.029 0.2068
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.002 0.0013 0.0013
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.011 0.1354
Echinococcus granulosus Aminotransferase class III 0.0021 0.0018 0.0018
Trypanosoma brucei cytochrome P450, putative 0.006 0.0147 0.1478
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0043 0.0043
Leishmania major glycerol uptake protein, putative 0.0261 0.0813 0.5793
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0021 0.0018 0.0026
Loa Loa (eye worm) hypothetical protein 0.0104 0.0291 0.0291
Brugia malayi nuclear receptor NHR-67 0.0029 0.0043 0.0043
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.0151 0.0151
Leishmania major DNA polymerase eta, putative 0.002 0.0014 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0021 0.0018 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0108
Brugia malayi MBOAT family protein 0.0261 0.0813 0.0813
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.0151 0.0151
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0308 0.0969 0.0969
Schistosoma mansoni ran 0.0022 0.002 0.002
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0261 0.0813 0.0813
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1665 0.5464 0.5464
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.0444 0.4454
Mycobacterium tuberculosis Possible penicillin-binding protein 0.165 0.5416 1
Schistosoma mansoni loxhd1 0.0042 0.0086 0.0086
Leishmania major cytochrome p450-like protein 0.006 0.0147 0.105
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0024 0.0027 0.0027
Brugia malayi nuclear receptor RXR 0.0029 0.0043 0.0043
Echinococcus granulosus dna polymerase eta 0.002 0.0014 0.0014
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0024 0.0027 0.0194
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.0047
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.029 0.357
Loa Loa (eye worm) hypothetical protein 0.0062 0.0151 0.0151
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0004
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0043 0.0043
Onchocerca volvulus 0.0258 0.0803 0.2498
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.002 0.0013 0.0013
Onchocerca volvulus Huntingtin homolog 0.0131 0.0381 0.1184
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.0151 0.0151
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0043 0.0043
Mycobacterium leprae conserved hypothetical protein 0.0258 0.0803 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.0151 0.0151
Mycobacterium ulcerans hypothetical protein 0.0258 0.0803 0.5708
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0258 0.0803 0.0803
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0024 0.0027 0.0044
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0444 0.3165
Loa Loa (eye worm) acetyltransferase 0.0308 0.0969 0.0969
Echinococcus granulosus cpg binding protein 0.0123 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0131 0.0381 0.0381
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0151 0.0151
Schistosoma mansoni rab6-interacting 0.0042 0.0086 0.0086
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0043 0.0043
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0366 0.0366
Schistosoma mansoni hypothetical protein 0.0024 0.0027 0.0027
Brugia malayi nuclear hormone receptor 0.0062 0.0151 0.0151
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0101 0.0101
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.0151 0.0151
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0024 0.0027 0.0194
Mycobacterium ulcerans aldehyde dehydrogenase 0.044 0.1404 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0014 0.0042
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0004 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0108
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0024 0.0027 0.0027
Loa Loa (eye worm) inositol-1 0.0036 0.0066 0.0066
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0144 0.0144
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0043 0.0043
Onchocerca volvulus 0.0258 0.0803 0.2498
Echinococcus multilocularis neuropeptide s receptor 0.0523 0.1679 0.1679
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.0151 0.0151
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0063 0.0063
Leishmania major trypanothione reductase 0.0049 0.011 0.0785
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0043 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.0151 0.0151
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0261 0.0813 0.0813
Brugia malayi conserved hypotetical protein 0.0029 0.0043 0.0043
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0091 0.0248 0.077
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0043 0.0043
Onchocerca volvulus 0.0062 0.0151 0.0471
Giardia lamblia Kinase, CMGC MAPK 0.0109 0.031 0.5148
Echinococcus granulosus zinc finger protein 0.2772 0.9134 0.9134
Schistosoma mansoni cpg binding protein 0.0123 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0258 0.0803 0.0803
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0024 0.0027 0.0027
Mycobacterium tuberculosis Probable lipase LipD 0.0258 0.0803 0.1477
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0014 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0014 0.0137
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0014 0.0014
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0095 0.0951
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.031 0.0964
Onchocerca volvulus 0.0986 0.3216 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0041 0.0082 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0014 0.0137
Trichomonas vaginalis D-aminoacylase, putative 0.0258 0.0803 0.2498
Loa Loa (eye worm) hypothetical protein 0.0062 0.0151 0.0151
Brugia malayi diacylglycerol acyltransferase 0.0261 0.0813 0.0813
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.015 0.0443 0.542
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.002 0.0013 0.0013
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0004 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0014 0.0137
Trypanosoma brucei protein kinase, putative 0.0109 0.031 0.3105
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0036
Entamoeba histolytica hypothetical protein 0.0261 0.0813 0.868
Echinococcus granulosus ubiquitin specific protease 41 0.0198 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0051 0.0117 0.0117
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0109 0.031 0.3105
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0042 0.0085 0.015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0062 0.0151 0.0151
Trichomonas vaginalis transmembrane protein nessy, putative 0.0261 0.0813 0.253
Schistosoma mansoni aldehyde dehydrogenase 0.0024 0.0027 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0035 0.0108
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0042 0.0085 0.015
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0004 0.0044
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0361 0.066
Echinococcus granulosus mitogen activated protein kinase 3 0.0109 0.031 0.031
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0066 0.0066
Echinococcus granulosus beta LACTamase domain containing family member 0.0258 0.0803 0.0803
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.0086 0.1059
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0024 0.0027 0.0123
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0464 0.1486 0.1486
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0319 0.0583
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0042 0.0085 0.058
Loa Loa (eye worm) hypothetical protein 0.0062 0.0151 0.0151
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0004 0.0026
Loa Loa (eye worm) hypothetical protein 0.0131 0.0381 0.0381
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0058 0.0058
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0024 0.0027 0.0274
Brugia malayi Doublecortin family protein 0.0042 0.0086 0.0086
Echinococcus granulosus guanine nucleotide binding protein G protein 0.002 0.0013 0.0013
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0127 0.0366 0.0366
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0043 0.0043
Schistosoma mansoni inositol monophosphatase 0.0036 0.0066 0.0066
Echinococcus multilocularis musashi 0.0026 0.0034 0.0034
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.002 0.0013 0.0013
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0014 0.0014
Brugia malayi beta-lactamase family protein 0.0258 0.0803 0.0803
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0144 0.0447
Schistosoma mansoni lamin 0.0026 0.0034 0.0034
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.3033 1 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0014 0.0014
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0186 0.0565 0.0565
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0014 0.0137
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0151 0.0151
Schistosoma mansoni zinc finger protein 0.3033 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0109 0.031 0.3105
Schistosoma mansoni importin beta-1 0.003 0.0047 0.0047
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0042 0.0085 0.015
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.002 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0062 0.0151 0.0151
Echinococcus multilocularis cpg binding protein 0.0123 0.0355 0.0355
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0261 0.0813 0.0813
Mycobacterium ulcerans aldehyde dehydrogenase 0.0024 0.0027 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.0151 0.0151
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0042 0.0085 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0108
Plasmodium vivax hypothetical protein, conserved 0.0258 0.0803 0.9873
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0127 0.0366 0.2609
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.002 0.0013 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0035 0.0108
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.0018 0.01
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0043 0.0043
Trypanosoma cruzi glycerol uptake protein, putative 0.0261 0.0813 0.8151
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0042 0.0085 0.015
Echinococcus granulosus intermediate filament protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0055 0.0055
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0261 0.0813 0.0813
Schistosoma mansoni nuclear receptor 0.0029 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0108
Schistosoma mansoni hypothetical protein 0.1253 0.4098 0.4098
Entamoeba histolytica Ran family GTPase 0.0022 0.002 0.0217
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0021 0.0018 0.0026
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0004 0.0036
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.0501 0.0918
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.002 0.0013 0.0013
Echinococcus granulosus expressed protein 0.002 0.0013 0.0013
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.002 0.0013 0.0013
Echinococcus multilocularis neuropeptide receptor A26 0.0523 0.1679 0.1679
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0151 0.0151
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0042 0.0085 0.015
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0036
Echinococcus multilocularis mitogen activated protein kinase 3 0.0109 0.031 0.031
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0028 0.0086
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0066 0.0204
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0198 0.0602 0.6424
Loa Loa (eye worm) hypothetical protein 0.0062 0.0151 0.0151
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0066 0.0204
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0319 0.0583
Schistosoma mansoni cellular tumor antigen P53 0.0104 0.0291 0.0291
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0299 0.0937 0.0937
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0042 0.0085 0.015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.0151 0.0151
Brugia malayi hypothetical protein 0.0042 0.0086 0.0086
Loa Loa (eye worm) G protein alpha subunit 3 0.002 0.0013 0.0013
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0034 0.0058 0.0058
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0021 0.0018 0.1002
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0261 0.0813 0.5793
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.0337
Brugia malayi Steroid receptor seven-up type 2 0.0062 0.0151 0.0151
Trypanosoma brucei glycerol uptake protein, putative 0.0261 0.0813 0.8151
Brugia malayi acetyltransferase, GNAT family protein 0.0308 0.0969 0.0969
Loa Loa (eye worm) hypothetical protein 0.0261 0.0813 0.0813
Mycobacterium ulcerans aldehyde dehydrogenase 0.044 0.1404 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0035 0.0108
Entamoeba histolytica hypothetical protein 0.0299 0.0937 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0043 0.0043
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0024 0.0027 0.0274
Mycobacterium ulcerans esterase/lipase LipP 0.0258 0.0803 0.5708
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0464 0.1486 0.1486
Onchocerca volvulus 0.0117 0.0333 0.1037
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.002 0.0013 0.0013
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0024 0.0027 0.0169
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.0203
Mycobacterium ulcerans hypothetical protein 0.0167 0.0501 0.3549
Brugia malayi Cytochrome P450 family protein 0.0164 0.0489 0.0489
Schistosoma mansoni lamin 0.0026 0.0034 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0036
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0319 0.0583
Loa Loa (eye worm) hypothetical protein 0.0033 0.0055 0.0055
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0014 0.0137
Trichomonas vaginalis D-aminoacylase, putative 0.0258 0.0803 0.2498
Loa Loa (eye worm) hypothetical protein 0.0261 0.0813 0.0813
Loa Loa (eye worm) hypothetical protein 0.1373 0.4497 0.4497
Brugia malayi hypothetical protein 0.0494 0.1584 0.1584
Loa Loa (eye worm) hypothetical protein 0.0042 0.0086 0.0086
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0014 0.0137
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0261 0.0813 0.0813
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.011 0.011
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0042 0.0085 0.015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0151 0.0151
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0024 0.0027 0.0169
Brugia malayi CXXC zinc finger family protein 0.0117 0.0333 0.0333
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0261 0.0813 1
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0024 0.0027 0.0274
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0261 0.0813 0.0813
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0198 0.0602 0.0602
Trichomonas vaginalis helicase, putative 0.0026 0.0035 0.0108
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0144 0.0144
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0042 0.0085 0.015
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0042 0.0085 0.015
Plasmodium falciparum importin beta, putative 0.003 0.0047 0.0572
Echinococcus granulosus survival motor neuron protein 1 0.0494 0.1584 0.1584
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.011 0.1104
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0024 0.0027 0.1688
Brugia malayi hypothetical protein 0.0029 0.0043 0.0043
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0024 0.0027 0.0274
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.002 0.0013 0.0013
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0024 0.0027 0.0044
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.0086 0.0086
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0014 0.0137
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0043 0.0043
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.0151 0.0151
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0144 0.0447
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.0151 0.0471
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0014 0.0097
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0144 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.0203
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0043 0.0043
Trichomonas vaginalis esterase, putative 0.0258 0.0803 0.2498
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0063
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.002 0.0013 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.0151 0.0151
Echinococcus multilocularis expressed protein 0.002 0.0013 0.0013
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0043 0.0043
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0024 0.0027 0.0169
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0014 0.0014
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0004 0.0036
Trypanosoma cruzi glycerol uptake protein, putative 0.0261 0.0813 0.8151
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0004 0.0036
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.002 0.0013 0.0041
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.0249
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.002 0.002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0066 0.0658
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0024 0.0027 0.0044
Schistosoma mansoni aldehyde dehydrogenase 0.044 0.1404 0.1404
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0043 0.0135
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0024 0.0027 0.0274
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0109 0.031 0.2207
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0147 0.0147
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0109 0.031 0.031
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0361 0.4366
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.002 0.0013 0.0013
Brugia malayi hypothetical protein 0.0042 0.0086 0.0086
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0024 0.0027 0.0123
Schistosoma mansoni cpg binding protein 0.0123 0.0355 0.0355
Onchocerca volvulus 0.0026 0.0034 0.0105
Schistosoma mansoni survival motor neuron protein 0.0101 0.0281 0.0281
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0319 0.3837
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0024 0.0027 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.0602 0.1872
Schistosoma mansoni aldehyde dehydrogenase 0.0024 0.0027 0.0027
Echinococcus granulosus lamin 0.0026 0.0034 0.0034
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0144 0.0144
Echinococcus granulosus GPCR family 2 0.0016 0.0001 0.0001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.0151 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0366 0.0366
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0101 0.0101
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0091 0.0248 0.3045
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0258 0.0803 0.0803
Mycobacterium tuberculosis Probable esterase LipL 0.0258 0.0803 0.1477
Schistosoma mansoni GTP-binding protein alpha subunit 0.002 0.0013 0.0013
Toxoplasma gondii cytochrome p450 superfamily protein 0.0042 0.0085 0.0604
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0258 0.0803 0.0803
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0086 0.0086
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0258 0.0803 0.0803
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0024 0.0027 0.0274
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0042 0.0085 0.015
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.006 0.0147 0.1027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.0151 0.0151
Brugia malayi follicle stimulating hormone receptor 0.025 0.0775 0.0775
Mycobacterium tuberculosis Probable reductase 0.0112 0.0319 0.0583
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0004 0.0026
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0144 0.0144
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0095 0.0951
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0024 0.0027 0.0044
Loa Loa (eye worm) cytochrome P450 0.0042 0.0085 0.0085
Schistosoma mansoni eyes absent homolog 0.0093 0.0256 0.0256
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.002 0.0013 0.0041
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0024 0.0027 0.0169
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0024 0.0027 0.0085
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0261 0.0813 0.0813
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0261 0.0813 0.0813
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0444 0.4454
Loa Loa (eye worm) doublecortin family protein 0.0042 0.0086 0.0086
Plasmodium vivax SET domain protein, putative 0.0127 0.0366 0.4504
Schistosoma mansoni sterol O-acyltransferase 1 0.0261 0.0813 0.0813
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0319 0.0583
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.002 0.0013 0.0013
Brugia malayi Thioredoxin reductase 0.0049 0.011 0.011
Leishmania major glycerol uptake protein, putative 0.0261 0.0813 0.5793
Echinococcus multilocularis microtubule associated protein 2 0.1434 0.47 0.47
Trichomonas vaginalis conserved hypothetical protein 0.0261 0.0813 0.253
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0464 0.1486 0.1486
Leishmania major aldehyde dehydrogenase, putative 0.0024 0.0027 0.0194
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Onchocerca volvulus 0.002 0.0013 0.0041
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0055 0.0055
Plasmodium falciparum thioredoxin reductase 0.0017 0.0004 0.0044
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.0151 0.0151
Echinococcus multilocularis Aminotransferase class III 0.0021 0.0018 0.0018
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.002 0.0249
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0867 0.282 0.282
Brugia malayi RNA, U transporter 1 0.0085 0.023 0.023
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0198 0.0602 0.6032
Brugia malayi ecdysteroid receptor 0.0062 0.0151 0.0151
Leishmania major aldehyde dehydrogenase, putative 0.0024 0.0027 0.0194
Mycobacterium leprae putative cytochrome p450 0.0042 0.0085 0.0856
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.0151 0.0151
Leishmania major glycerol uptake protein, putative 0.0261 0.0813 0.5793
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0062 0.0151 0.0151
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.002 0.0013 0.0041
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0144 0.1001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0036
Brugia malayi nuclear receptor RXR 0.0033 0.0055 0.0055
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0066 0.0467
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0151 0.0151
Echinococcus granulosus histone acetyltransferase KAT2B 0.03 0.094 0.094
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0108
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0021 0.0018 1
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0055 0.0055
Echinococcus granulosus guanine nucleotide binding protein subunit 0.002 0.0013 0.0013
Echinococcus granulosus ornithine aminotransferase 0.0021 0.0018 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0035 0.0108
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0151 0.0151
Trypanosoma brucei trypanothione reductase 0.0049 0.011 0.1104
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0024 0.0027 0.0274
Leishmania major glycerol uptake protein, putative 0.0261 0.0813 0.5793
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0109 0.031 0.3105
Leishmania major hypothetical protein, conserved 0.0258 0.0803 0.5719
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0043 0.0043
Mycobacterium ulcerans hypothetical protein 0.015 0.0443 0.314
Brugia malayi F/Y-rich N-terminus family protein 0.004 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0014 0.0137
Loa Loa (eye worm) MBOAT family protein 0.3033 1 1
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0021 0.0018 0.0018
Plasmodium falciparum thioredoxin reductase 0.0049 0.011 0.1354
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.002 0.0145
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0024 0.0027 0.0291
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0024 0.0027 0.0274
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0144 0.1732
Trypanosoma brucei unspecified product 0.002 0.0014 0.0137
Loa Loa (eye worm) hypothetical protein 0.0033 0.0055 0.0055
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.029 0.291
Entamoeba histolytica vacuolar protein sorting 26 0.0261 0.0813 0.868
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.044 0.1404 1
Echinococcus granulosus tumor protein p63 0.0709 0.2298 0.2298
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0001 0.0001
Plasmodium vivax ornithine aminotransferase, putative 0.0021 0.0018 0.0217
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0021 0.0018 0.0126
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0151 0.0151
Brugia malayi MBOAT family protein 0.0261 0.0813 0.0813
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0042 0.0085 0.058
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0086 0.0086
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0042 0.0085 0.015
Schistosoma mansoni aldehyde dehydrogenase 0.044 0.1404 0.1404
Schistosoma mansoni lipoxygenase 0.0111 0.0314 0.0314
Onchocerca volvulus 0.0261 0.0813 0.253
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.0151 0.0151
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0042 0.0085 0.058
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0024 0.0027 0.0274
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0024 0.0027 0.0274
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0258 0.0803 0.1477
Trichomonas vaginalis D-aminoacylase, putative 0.0258 0.0803 0.2498
Brugia malayi intermediate filament protein 0.0026 0.0034 0.0034
Leishmania major glycerol uptake protein, putative 0.0261 0.0813 0.5793
Entamoeba histolytica hypothetical protein, conserved 0.0261 0.0813 0.868
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0042 0.0085 0.015
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0024 0.0027 0.0169
Echinococcus granulosus dna polymerase kappa 0.002 0.0014 0.0014
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.011 0.011
Echinococcus multilocularis 0.0042 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0104 0.029 0.029
Brugia malayi Importin beta-1 subunit 0.003 0.0047 0.0047
Plasmodium vivax importin-beta 2, putative 0.003 0.0047 0.0572
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0024 0.0027 0.0027
Echinococcus multilocularis beta LACTamase domain containing family member 0.0258 0.0803 0.0803
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0001 0.0001
Schistosoma mansoni aldehyde dehydrogenase 0.0024 0.0027 0.0027
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.0151 0.0471
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.0151 0.0151
Brugia malayi hypothetical protein 0.0033 0.0055 0.0055
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0047 0.0466
Schistosoma mansoni hypothetical protein 0.0101 0.0281 0.0281
Schistosoma mansoni trimeric G-protein alpha o subunit 0.002 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0108
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0042 0.0085 0.085
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0086 0.0086
Onchocerca volvulus 0.0127 0.0366 0.1139
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0024 0.0027 0.0274
Echinococcus granulosus FTZ F1 alpha 0.0062 0.0151 0.0151
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0055 0.0055
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0004 0.0026
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0147 0.0147
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0055 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.0151 0.0151
Brugia malayi hypothetical protein 0.0033 0.0055 0.0055
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.031 0.0964
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0095 0.0951
Brugia malayi hypothetical protein 0.0029 0.0043 0.0043
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0024 0.0027 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.0151 0.0151
Trichomonas vaginalis porcupine, putative 0.0261 0.0813 0.253
Schistosoma mansoni hypothetical protein 0.0035 0.0063 0.0063
Toxoplasma gondii thioredoxin reductase 0.0049 0.011 0.0785
Trypanosoma brucei PAB1-binding protein , putative 0.0104 0.029 0.291
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0024 0.0027 0.0274
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.0086 0.0086
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.002 0.0013 0.0013
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0144 0.239
Brugia malayi Cytochrome P450 family protein 0.0042 0.0085 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Echinococcus granulosus lamin dm0 0.0026 0.0034 0.0034
Echinococcus granulosus dnaJ subfamily B 0.1253 0.4098 0.4098
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0066 0.07
Brugia malayi hypothetical protein 0.0093 0.0256 0.0256
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0036
Brugia malayi beta-lactamase 0.0258 0.0803 0.0803
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0047 0.0466
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0066 0.0443
Trypanosoma cruzi hypothetical protein, conserved 0.0258 0.0803 0.8048
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0258 0.0803 0.5708
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.002
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0053 0.0452
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Loa Loa (eye worm) CXXC zinc finger family protein 0.0117 0.0333 0.0333
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0055 0.0055
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0014 0.0014
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0024 0.0027 0.0027
Brugia malayi hypothetical protein 0.0067 0.0169 0.0169
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0042 0.0085 0.058
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0042 0.0085 0.085
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0024 0.0027 0.0169
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0024 0.0027 0.0169
Brugia malayi beta-lactamase family protein 0.0258 0.0803 0.0803
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0024 0.0027 0.0169
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.015 0.0443 0.0812
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0108
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.002 0.0013 0.0041
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.0151 0.0151
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0024 0.0027 0.0027
Giardia lamblia DINP protein human, muc B family 0.002 0.0014 0.0227
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0066 0.0204

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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