Detailed information for compound 873821

Basic information

Technical information
  • TDR Targets ID: 873821
  • Name: 2-[3-[[(3,4-dimethoxyphenyl)amino]methyl]-7-m ethyl-2-oxoquinolin-1-yl]-N-(3-methylphenyl)a cetamide
  • MW: 471.548 | Formula: C28H29N3O4
  • H donors: 2 H acceptors: 2 LogP: 4.58 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(NCc2cc3ccc(cc3n(c2=O)CC(=O)Nc2cccc(c2)C)C)ccc1OC
  • InChi: 1S/C28H29N3O4/c1-18-6-5-7-23(12-18)30-27(32)17-31-24-13-19(2)8-9-20(24)14-21(28(31)33)16-29-22-10-11-25(34-3)26(15-22)35-4/h5-15,29H,16-17H2,1-4H3,(H,30,32)
  • InChiKey: STNDDAKQPHIFFV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-[[(3,4-dimethoxyphenyl)amino]methyl]-7-methyl-2-oxo-1-quinolyl]-N-(3-methylphenyl)acetamide
  • 2-[3-[[(3,4-dimethoxyphenyl)amino]methyl]-2-keto-7-methyl-1-quinolyl]-N-(3-methylphenyl)acetamide
  • 2-[3-[[(3,4-dimethoxyphenyl)amino]methyl]-7-methyl-2-oxo-quinolin-1-yl]-N-(3-methylphenyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aldehyde dehydrogenase 0.005 0.024 0.1444
Brugia malayi hypothetical protein 0.0552 0.3141 0.314
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0064 0.0943
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0081 0.008
Trichomonas vaginalis DNA polymerase eta, putative 0.0035 0.0157 0.0947
Giardia lamblia DINP protein human, muc B family 0.0035 0.0157 0.0947
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0026 0.0026
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.024 0.2893
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0035 0.0157 0.0947
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0027 0.0107 0.0107
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0108 0.0108
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0097
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0113 0.0608 0.3664
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0169 0.0169
Schistosoma mansoni hypothetical protein 0.0066 0.0333 0.0333
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0108 0.0108
Trichomonas vaginalis CMGC family protein kinase 0.0042 0.0194 0.1167
Schistosoma mansoni cytochrome P450 0.0022 0.0081 0.0081
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.0787 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0019 0.0062 0.0373
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0011 0.0017 0.0101
Schistosoma mansoni hypothetical protein 0.0033 0.0145 0.0145
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0081 0.008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.012 0.012
Trichomonas vaginalis adenylate cyclase type, putative 0.0011 0.0016 0.0097
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0107
Mycobacterium ulcerans hypothetical protein 0.0019 0.0062 0.0586
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0108 0.0107
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0026 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0035 0.0157 0.81
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0043
Loa Loa (eye worm) hypothetical protein 0.0163 0.0894 0.0893
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0027 0.0107 0.0107
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0019 0.0062 0.0062
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0039 0.0038
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0295 0.1659 0.1658
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0157 0.2498
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0015 0.0039 0.0234
Echinococcus granulosus mitogen activated protein kinase 3 0.0042 0.0194 0.0194
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0035 0.0157 0.1438
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0221 0.0221
Treponema pallidum fructose-bisphosphate aldolase 0.0295 0.1659 0.1607
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0029 0.012 0.1884
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0027 0.0107 0.0107
Echinococcus multilocularis neuropeptide s receptor 0.0379 0.2143 0.2143
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0094 0.0568
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0081 0.0399
Trypanosoma brucei DNA damage repair protein, putative 0.0011 0.0017 0.0161
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0295 0.1659 0.1658
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0011 0.0016 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0119
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0019 0.0062 0.0143
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0019 0.0062 0.0062
Echinococcus granulosus hyperpolarization activated cyclic 0.0027 0.0107 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0017 0.0788
Brugia malayi hypothetical protein 0.0021 0.0072 0.0071
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0015 0.0039 0.0527
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0111 0.011
Leishmania major protein kinase A regulatory subunit, putative 0.0019 0.0062 0.2024
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0081 0.0399
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0108 0.0108
Onchocerca volvulus 0.0027 0.0111 0.0085
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0029 0.012 0.012
Schistosoma mansoni Smad4 0.0015 0.0039 0.0039
Brugia malayi ecdysteroid receptor 0.0027 0.0108 0.0107
Echinococcus granulosus cGMP dependent protein kinase 0.0019 0.0064 0.0064
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0108 0.0108
Schistosoma mansoni sodium/chloride dependent transporter 0.174 1 1
Leishmania major hypothetical protein, unknown function 0.0019 0.0062 0.2024
Schistosoma mansoni coup transcription factor 0.0027 0.0108 0.0108
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0072 0.0436
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0107
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0081 0.1226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0056
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0029 0.012 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0035 0.0157 0.81
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0097
Echinococcus multilocularis geminin 0.0309 0.1741 0.1741
Echinococcus granulosus expressed conserved protein 0.0075 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0006
Leishmania major cytochrome p450-like protein 0.0022 0.0081 0.287
Echinococcus granulosus neuropeptide s receptor 0.0379 0.2143 0.2143
Schistosoma mansoni nuclear receptor nhr-48 0.0013 0.0026 0.0026
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0011 0.0016 0.0097
Echinococcus granulosus dna polymerase eta 0.0035 0.0157 0.0157
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.008 0.0417 0.2515
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0035 0.0034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1659 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0029 0.012 0.0119
Brugia malayi Egg laying defective protein 4 0.0019 0.0064 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0108 0.0108
Brugia malayi Pre-SET motif family protein 0.0024 0.0094 0.0093
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0019 0.0064 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1659 1
Echinococcus multilocularis mitogen activated protein kinase 0.0042 0.0194 0.0194
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0019 0.0062 0.0373
Brugia malayi isocitrate dehydrogenase 0.0029 0.012 0.0119
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0108 0.0107
Trypanosoma brucei cAMP response protein 1, putative 0.0019 0.0062 0.0912
Echinococcus granulosus L aminoadipate semialdehyde 0.0068 0.0345 0.0345
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0081 0.4119
Echinococcus granulosus cGMP dependent protein kinase 1 0.0019 0.0064 0.0064
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0042 0.0197 0.0196
Trypanosoma brucei cAMP binding protein, putative 0.0019 0.0062 0.0912
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0108 0.0108
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0081 0.083
Schistosoma mansoni voltage-gated potassium channel 0.0037 0.0169 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Loa Loa (eye worm) hypothetical protein 0.174 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0035 0.0034
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0026 0.0025
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.024 0.2893
Echinococcus granulosus calcium activated potassium channel 0.0008 0.0001 0.0001
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0042 0.0194 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0094 0.1446
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0002 0.001
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0081 0.0487
Entamoeba histolytica hypothetical protein 0.0066 0.0333 0.2007
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0081 0.0081
Leishmania major hypothetical protein, conserved 0.0019 0.0062 0.2024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Schistosoma mansoni hypothetical protein 0.0029 0.012 0.012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0029 0.012 0.012
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0015 0.0039 0.1935
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0108 0.0108
Toxoplasma gondii hypothetical protein 0.0295 0.1659 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0081 0.0399
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0081 0.083
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0057 0.0522
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0026
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0025
Onchocerca volvulus 0.0295 0.1659 0.1637
Mycobacterium tuberculosis Conserved protein 0.0019 0.0062 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0157 0.2498
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0026 0.0026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0221 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Echinococcus granulosus microtubule associated protein 2 0.126 0.7231 0.7231
Echinococcus multilocularis sodium and chloride dependent glycine 0.0295 0.1659 0.1659
Brugia malayi MAP kinase sur-1 0.0042 0.0194 0.0193
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0019 0.0062 0.0373
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0295 0.1659 0.1659
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0029 0.012 0.6178
Loa Loa (eye worm) hypothetical protein 0.0295 0.1659 0.1658
Brugia malayi Cyclic-nucleotide gated cation channel 0.0027 0.0107 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0157 0.2498
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0295 0.1659 0.1659
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0037 0.0169 0.0168
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0039 0.0988
Loa Loa (eye worm) hypothetical protein 0.0008 0.0002 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0081 0.0399
Schistosoma mansoni sodium-dependent amino acid transporter 0.0295 0.1659 0.1659
Trichomonas vaginalis hypothetical protein 0.0011 0.0016 0.0097
Echinococcus granulosus dna polymerase kappa 0.0035 0.0157 0.0157
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0081 0.008
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0081 0.0399
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0025
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0019 0.0062 0.0373
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0019 0.0062 0.0062
Trypanosoma cruzi protein kinase A regulatory subunit 0.0019 0.0062 0.3138
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0056
Schistosoma mansoni smad1 5 8 and 0.0015 0.0039 0.0039
Mycobacterium ulcerans hypothetical protein 0.0019 0.0062 0.0586
Brugia malayi nuclear receptor RXR 0.0014 0.0035 0.0034
Onchocerca volvulus 0.0193 0.1069 0.1046
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0029 0.012 0.1884
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0107 0.0107
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0035 0.0035
Echinococcus granulosus sterol regulatory element binding protein 0.0034 0.0153 0.0153
Mycobacterium ulcerans hypothetical protein 0.0019 0.0062 0.0586
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0053
Echinococcus granulosus Protein patched homolog 1 0.0034 0.0153 0.0153
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0057 0.0344
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0072 0.1086
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0039 0.0527
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0295 0.1659 0.1659
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0157 0.2498
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0221 0.022
Mycobacterium leprae putative cytochrome p450 0.0022 0.0081 0.0838
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0094 0.0094
Onchocerca volvulus 0.0024 0.0094 0.0068
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0168
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0082 0.0424 0.0424
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0295 0.1659 0.1658
Echinococcus granulosus Niemann Pick C1 protein 0.0115 0.0616 0.0616
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.002 0.0071 0.1057
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0019 0.0062 0.0373
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0221 0.022
Schistosoma mansoni 60S ribosomal protein L21 0.0019 0.0061 0.0061
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0081 0.0838
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0042 0.0194 0.7936
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0081 0.0399
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0091
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0092 0.0091
Schistosoma mansoni hypothetical protein 0.0029 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0108 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0108 0.0107
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0062 0.0143
Trypanosoma brucei protein kinase, putative 0.0042 0.0194 0.3106
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0081 0.083
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0035 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0094 0.0094
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0157 0.81
Plasmodium falciparum amino acid transporter, putative 0.0295 0.1659 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0081 0.4119
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0295 0.1659 0.1659
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0108 0.0108
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0081 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Schistosoma mansoni smad1 5 8 and 0.0015 0.0039 0.0039
Loa Loa (eye worm) serotonin transporter b 0.174 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0107 0.0107
Brugia malayi cytochrome P450 0.0022 0.0081 0.008
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0019 0.0062 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1659 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Loa Loa (eye worm) Smad1 0.0015 0.0039 0.0038
Echinococcus multilocularis L aminoadipate semialdehyde 0.0068 0.0345 0.0345
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0011 0.0016 0.0097
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0019 0.0064 0.0384
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0026 0.0025
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0019 0.0062 0.0062
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0068 0.0345 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Mycobacterium ulcerans transcriptional regulatory protein 0.0019 0.0062 0.0586
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0019 0.0062 0.0912
Trichomonas vaginalis set domain proteins, putative 0.0193 0.1069 0.6444
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.0062 0.0373
Loa Loa (eye worm) AGC/PKG protein kinase 0.0019 0.0064 0.0063
Schistosoma mansoni hypothetical protein 0.0309 0.1741 0.1741
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0027 0.0107 0.0106
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0019 0.0062 0.0062
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0056
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.005 0.024 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0157 0.2498
Schistosoma mansoni smad1 5 8 and 0.0015 0.0039 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0221 0.0221
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0019 0.0064 0.0384
Brugia malayi Cytochrome P450 family protein 0.0022 0.0081 0.008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0108 0.0107
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0009 0.0007 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Onchocerca volvulus 0.0027 0.0111 0.0085
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0015 0.0039 0.0039
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0019 0.0064 0.061
Entamoeba histolytica hypothetical protein 0.0066 0.0333 0.2007
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0107
Brugia malayi Isocitrate dehydrogenase 0.0029 0.012 0.0119
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0039 0.0039
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0019 0.0062 0.0061
Entamoeba histolytica hypothetical protein 0.0019 0.0064 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0019 0.0062 0.0062
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0019 0.0062 0.0062
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.0062 0.0373
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0295 0.1659 0.1659
Leishmania major hypothetical protein, conserved 0.0019 0.0062 0.2024
Loa Loa (eye worm) transcription factor SMAD2 0.0218 0.1213 0.1212
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0097
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0034
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0061 0.0061
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0015 0.0039 0.0039
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0019 0.0062 0.0373
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0002 0.001
Echinococcus multilocularis protein patched 0.0034 0.0153 0.0153
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0026 0.0026
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0042 0.0194 1
Echinococcus granulosus neuropeptide receptor A26 0.0379 0.2143 0.2143
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0064 0.0064
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0019 0.0062 0.0062
Schistosoma mansoni sodium/chloride dependent transporter 0.0296 0.1661 0.1661
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0016 0.0097
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0081 0.083
Trichomonas vaginalis adenylate cyclase type III, putative 0.0011 0.0016 0.0097
Leishmania major phosphatidylinositol kinase related protein, putative 0.0015 0.0039 0.0995
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0027 0.0107 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Echinococcus multilocularis dna polymerase eta 0.0035 0.0157 0.0157
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0016 0.0097
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0008 0.0002 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0062 0.0313 0.0312
Trypanosoma cruzi cAMP response protein 1 0.0019 0.0062 0.3138
Echinococcus multilocularis neuropeptide receptor A26 0.0379 0.2143 0.2143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0221 0.0221
Brugia malayi tailless protein 0.0013 0.0026 0.0025
Onchocerca volvulus 0.0068 0.0345 0.032
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0081 0.083
Plasmodium falciparum cGMP-dependent protein kinase 0.0019 0.0064 0.0386
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0081 0.083
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0027 0.0107 0.0107
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0295 0.1659 1
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0295 0.1659 1
Brugia malayi CHE-14 protein 0.0034 0.0153 0.0152
Echinococcus granulosus Niemann Pick C1 protein 0.008 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0025
Leishmania major hypothetical protein, conserved 0.0019 0.0062 0.2024
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0081 0.083
Leishmania major DNA polymerase kappa, putative 0.0035 0.0157 0.6299
Giardia lamblia GTOR 0.0015 0.0039 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0108 0.0107
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0295 0.1659 0.1658
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0009 0.0007 0.0007
Echinococcus multilocularis hyperpolarization activated cyclic 0.0027 0.0107 0.0107
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0019 0.0062 0.0062
Schistosoma mansoni patched 1 0.0034 0.0153 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0019 0.0064 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0108 0.0108
Plasmodium falciparum DNA repair protein REV1, putative 0.0011 0.0017 0.0101
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.012 0.012
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0019 0.0064 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0108 0.0107
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0025
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0016 0.0097
Brugia malayi hypothetical protein 0.0013 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0025
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.0054 0.2739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0081 0.083
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0097
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0092 0.0977
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0029
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0026 0.0026
Toxoplasma gondii isocitrate dehydrogenase 0.0029 0.012 0.0725
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0029 0.012 0.0725
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0019 0.0062 0.0062
Trichomonas vaginalis adenylate cyclase type, putative 0.0011 0.0016 0.0097
Schistosoma mansoni hypothetical protein 0.0019 0.0062 0.0062
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0295 0.1659 0.1659
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0097
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0011 0.0016 0.0097
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0295 0.1659 0.1659
Brugia malayi MH2 domain containing protein 0.0015 0.0039 0.0038
Brugia malayi ecdysone receptor 0.0013 0.0026 0.0025
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0011 0.0016 0.0097
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0081 0.0399
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0026 0.0026
Schistosoma mansoni aldehyde dehydrogenase 0.005 0.024 0.024
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0011 0.0016 0.0097
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0108 0.0082
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0108 0.0108
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0019 0.0062 0.0143
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.017 0.0934 0.0933
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0092 0.0984
Schistosoma mansoni lamin 0.0027 0.0111 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0094 0.0094
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0016 0.0097
Trypanosoma cruzi cAMP binding protein, putative 0.0019 0.0062 0.3138
Echinococcus multilocularis Niemann Pick C1 protein 0.008 0.0417 0.0417
Echinococcus multilocularis expressed conserved protein 0.0075 0.0389 0.0389
Mycobacterium ulcerans transmembrane transport protein 0.0019 0.0062 0.0586
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0295 0.1659 1
Brugia malayi hypothetical protein 0.0066 0.0333 0.0332
Echinococcus granulosus lamin dm0 0.0027 0.0111 0.0111
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0107 0.0643
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0026 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0002 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0037 0.0169 0.0169
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0108 0.0108
Echinococcus granulosus geminin 0.0309 0.1741 0.1741
Echinococcus multilocularis isocitrate dehydrogenase 0.0029 0.012 0.012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0092 0.0552
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0034
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0081 0.4119
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1659 1
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0016 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0108 0.0107
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0108 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0108 0.0107
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0017 0.0161
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0108 0.0107
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0019 0.0062 0.0373
Loa Loa (eye worm) MH2 domain-containing protein 0.0218 0.1213 0.1212
Schistosoma mansoni hypothetical protein 0.0033 0.0145 0.0145
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0081 0.083
Loa Loa (eye worm) pax transcription factor protein 2 0.0196 0.1087 0.1086
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0039 0.0527
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0157 0.2498
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0092 0.0552
Brugia malayi nuclear receptor RXR 0.0013 0.0026 0.0025
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0092 0.3375
Echinococcus multilocularis GPCR, family 2 0.0029 0.012 0.012
Brugia malayi hypothetical protein 0.0295 0.1659 0.1658
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0091 0.0479 0.0478
Loa Loa (eye worm) hypothetical protein 0.0295 0.1659 0.1658
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0108 0.0107
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0015 0.0039 0.1943
Echinococcus multilocularis sterol regulatory element binding protein 0.0034 0.0153 0.0153
Echinococcus granulosus mothers against decapentaplegic 5 0.0015 0.0039 0.0039
Onchocerca volvulus 0.0552 0.3141 0.3123
Brugia malayi hypothetical protein 0.0013 0.0026 0.0025
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0035 0.0157 0.0157
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0019 0.0062 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.011
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0121 0.0653 0.0652
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0163 0.0894 0.087
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0092 0.0554
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0121 0.0653 0.0653
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0019 0.0064 0.0064
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0108 0.0082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0156
Echinococcus granulosus sodium and chloride dependent glycine 0.0295 0.1659 0.1659
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0008 0.0002 0.0002
Echinococcus granulosus cGMP dependent protein kinase 1 0.0019 0.0064 0.0064
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.1659 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0081 0.0399
Echinococcus multilocularis dna polymerase kappa 0.0035 0.0157 0.0157
Onchocerca volvulus 0.0024 0.0092 0.0066
Trypanosoma cruzi DNA damage repair protein, putative 0.0011 0.0017 0.0788
Echinococcus multilocularis musashi 0.0027 0.0111 0.0111
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0081 0.0399
Entamoeba histolytica hypothetical protein 0.002 0.0071 0.0426
Echinococcus granulosus TGF beta signal transducer SmadC 0.0015 0.0039 0.0039
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0072 0.0436
Loa Loa (eye worm) hypothetical protein 0.0068 0.0345 0.0344
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0015 0.0039 0.0988
Loa Loa (eye worm) hypothetical protein 0.0024 0.0094 0.0093
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0038 0.0037
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0029 0.012 0.012
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0019 0.0062 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Loa Loa (eye worm) hypothetical protein 0.174 1 1
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0019 0.0062 0.0062
Mycobacterium ulcerans hypothetical protein 0.0024 0.0092 0.0977
Echinococcus multilocularis calcium activated potassium channel 0.0008 0.0001 0.0001
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0035 0.0157 0.0157
Trypanosoma cruzi DNA damage repair protein, putative 0.0011 0.0017 0.0788
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0025
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0026 0.0026
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0661 0.3773 0.3773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Brugia malayi nuclear receptor NHR-88 0.0027 0.0108 0.0107
Schistosoma mansoni DNA polymerase eta 0.0035 0.0157 0.0157
Toxoplasma gondii FATC domain-containing protein 0.002 0.0071 0.0426
Trypanosoma brucei Flagellar Member 6 0.0019 0.0062 0.0912
Schistosoma mansoni hypothetical protein 0.0009 0.0007 0.0007
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0029 0.012 0.6178
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0042 0.0194 0.7936
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.003 0.003
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0016 0.0097
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0107
Echinococcus multilocularis expressed conserved protein 0.0019 0.0064 0.0064
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0039 0.1935
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0091
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0026 0.0025
Echinococcus multilocularis hyperpolarization activated cyclic 0.0027 0.0107 0.0107
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0107 0.0107
Brugia malayi Cytochrome P450 family protein 0.0022 0.0081 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0042 0.0194 1
Echinococcus multilocularis smad 0.0015 0.0039 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0064 0.0064
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0081 0.083
Brugia malayi Latrophilin receptor protein 2 0.0029 0.012 0.0119
Echinococcus granulosus hyperpolarization activated cyclic 0.0027 0.0107 0.0107
Echinococcus multilocularis 0.0022 0.0081 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0097
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0019 0.0062 0.3138
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0108 0.0108
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0011 0.0017 0.0101
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0039 0.0038
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0062 0.0143
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0034
Echinococcus multilocularis sodium and chloride dependent glycine 0.0295 0.1659 0.1659
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0072 0.0436
Echinococcus multilocularis serotonin transporter 0.174 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0132 0.0715 0.0715
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0027 0.0107 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0007 0.0043
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0011 0.0016 0.0097
Onchocerca volvulus 0.0019 0.0062 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0056
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0295 0.1659 0.1658
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0091
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0111 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0092 0.0554
Echinococcus granulosus patatin phospholipase domain containing protein 0.0019 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0221 0.0221
Treponema pallidum sodium- and chloride- dependent transporter 0.174 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.002 0.0071 0.0071
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.0787 1
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0016 0.0097
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0027 0.0107 0.0107
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0108 0.0108
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.0787 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0029 0.012 0.4643
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0157 0.2498
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0081 0.0399
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0019 0.0062 0.0061
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0072 0.0436
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0016 0.0097
Onchocerca volvulus 0.174 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0015 0.0039 0.1935
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0108 0.0107
Loa Loa (eye worm) hypothetical protein 0.0062 0.0313 0.0312
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0108 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0157 0.2498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Schistosoma mansoni hypothetical protein 0.0113 0.0608 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0108 0.0107
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0108 0.0108
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0057 0.0077
Trypanosoma brucei DNA damage repair protein, putative 0.0011 0.0017 0.0161
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0094 0.0094
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0295 0.1659 0.1658
Schistosoma mansoni aldehyde dehydrogenase 0.005 0.024 0.024
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0026 0.0026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0108 0.0108
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0295 0.1659 0.1659
Echinococcus granulosus serotonin transporter 0.174 1 1
Leishmania major cytochrome p450-like protein 0.0022 0.0081 0.287
Echinococcus multilocularis Smad4 0.0015 0.0039 0.0039
Plasmodium falciparum transporter, putative 0.0295 0.1659 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0026 0.0026
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.174 1 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0042 0.0194 0.1167
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0092 0.3375
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0015 0.0039 0.0988
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0107 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0002 0.001
Echinococcus multilocularis X box binding protein 1 0.0235 0.1311 0.1311
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0034
Schistosoma mansoni transcription factor LCR-F1 0.0066 0.0333 0.0333
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0092 0.0554
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0108 0.0108
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1659 1
Brugia malayi MH1 domain containing protein 0.0015 0.0039 0.0038
Loa Loa (eye worm) norepinephrine transporter 0.174 1 1
Schistosoma mansoni nuclear receptor 0.0013 0.0026 0.0026
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0111 0.011
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0042 0.0194 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0094 0.1446
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0013 0.0026 0.0026
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0108 0.0108
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0081 0.0399
Trypanosoma cruzi DNA polymerase kappa, putative 0.0035 0.0157 0.81
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0002 0.001
Echinococcus multilocularis protein dispatched 1 0.0039 0.0181 0.0181
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0092 0.0977
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0033 0.0145 0.0145
Echinococcus granulosus histone lysine methyltransferase setb 0.0024 0.0094 0.0094
Toxoplasma gondii isocitrate dehydrogenase 0.0029 0.012 0.0725
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0017 0.0161
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0081 0.4119
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0035 0.0035
Brugia malayi hypothetical protein 0.0013 0.003 0.0029
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0019 0.0062 0.0061
Brugia malayi intermediate filament protein 0.0027 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0295 0.1659 0.1658
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0026 0.0026
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0011 0.0018 0.0186
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0092 0.0977
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0108 0.0107
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0057 0.0344
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0039 0.0988
Plasmodium vivax amine transporter, putative 0.0295 0.1659 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0029 0.012 0.012
Leishmania major protein kinase, putative 0.0019 0.0064 0.2121
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0081 0.083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0108 0.0107
Loa Loa (eye worm) hypothetical protein 0.0295 0.1659 0.1658
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0019 0.0062 0.0373
Schistosoma mansoni terminal deoxycytidyl transferase 0.0035 0.0157 0.0157
Brugia malayi hypothetical protein 0.0014 0.0035 0.0034
Schistosoma mansoni DNA polymerase IV / kappa 0.0011 0.0017 0.0017
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis CMGC family protein kinase 0.0042 0.0194 0.1167
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.0106
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0016 0.0097
Mycobacterium leprae Conserved hypothetical protein 0.0019 0.0062 0.0593
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0081 0.287
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0026 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0071 0.0426
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0081 0.083
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0081 0.083
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0081 0.083
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0019 0.0064 0.0384
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0157 0.2498
Schistosoma mansoni hypothetical protein 0.0029 0.012 0.012
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0092 0.0977
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0019 0.0062 0.003
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.005 0.024 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.0062 0.0062
Echinococcus multilocularis Niemann Pick C1 protein 0.0115 0.0616 0.0616
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0064 0.0064
Echinococcus multilocularis microtubule associated protein 2 0.126 0.7231 0.7231
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0017 0.0161
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0081 0.083
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0091 0.0479 0.0478
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0097
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.003 0.003
Echinococcus granulosus voltage gated potassium channel 0.0037 0.0169 0.0169
Brugia malayi Niemann-Pick C1 protein precursor 0.008 0.0417 0.0416
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0029 0.012 0.0725
Brugia malayi Smad1 0.0015 0.0039 0.0038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0002 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.012 0.0119
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0035 0.0034
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Mycobacterium ulcerans DNA polymerase IV 0.0035 0.0157 0.1823
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0121 0.0653 0.0653
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0011 0.0017 0.0101
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Brugia malayi nuclear hormone receptor 0.0013 0.0026 0.0025
Toxoplasma gondii target of rapamycin (TOR), putative 0.0015 0.0039 0.0234
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0019 0.0062 0.0373
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0081 0.083
Loa Loa (eye worm) DR-78 0.0013 0.0026 0.0025
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0081 0.008
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0019 0.0064 0.0002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0035 0.0157 0.0156
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.0062 0.0062
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0092 0.3375
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0081 0.0399
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0026 0.0025
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0295 0.1659 0.1659
Brugia malayi hypothetical protein 0.0014 0.0035 0.0034
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0026 0.0025
Loa Loa (eye worm) cytochrome P450 0.0022 0.0081 0.008
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.1659 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0107 0.0107
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis CMGC family protein kinase 0.0042 0.0194 0.1167
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0094 0.1446
Trypanosoma brucei unspecified product 0.0024 0.0094 0.1446
Schistosoma mansoni lamin 0.0027 0.0111 0.0111
Leishmania major regulatory subunit of protein kinase a-like protein 0.0019 0.0062 0.2024
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0081 0.0399
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0153 0.092
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0295 0.1659 0.1659
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0072 0.3682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0108 0.0082
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0011 0.0016 0.0097
Brugia malayi MH2 domain containing protein 0.0218 0.1213 0.1212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0015 0.0039 0.0234
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0295 0.1659 0.1659
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0017 0.0161
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0092 0.0977
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0108 0.0107
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0081 0.1226
Schistosoma mansoni smad 0.0015 0.0039 0.0039
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0295 0.1659 0.1659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0002 0.001
Brugia malayi N-terminal motif family protein 0.0163 0.0894 0.0893
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0015 0.0039 0.0988
Schistosoma mansoni microtubule-associated protein tau 0.126 0.7231 0.7231
Brugia malayi Cytochrome P450 family protein 0.0022 0.0081 0.008
Echinococcus multilocularis mitogen activated protein kinase 3 0.0042 0.0194 0.0194
Trypanosoma cruzi DNA polymerase eta, putative 0.0011 0.0017 0.0788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0035 0.0035
Brugia malayi nuclear receptor NHR-88 0.0013 0.0026 0.0025
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0039 0.0038
Plasmodium vivax DNA repair protein REV1, putative 0.0011 0.0017 0.0101
Leishmania major protein kinase, putative 0.0019 0.0064 0.2121
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0029 0.012 0.012
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0029 0.012 0.012
Trypanosoma brucei DNA polymerase eta, putative 0.0035 0.0157 0.2498
Mycobacterium ulcerans hypothetical protein 0.0019 0.0062 0.0586
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0011 0.0016 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0194 0.0194
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.005 0.024 0.024
Schistosoma mansoni zinc finger protein 0.0013 0.0026 0.0026
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0039 0.0038
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0081 0.4119
Schistosoma mansoni fkbp-rapamycin associated protein 0.0008 0.0002 0.0002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0309 0.1741 0.1741
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0011 0.0016 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0035 0.0157 0.81
Brugia malayi nuclear receptor NHR-67 0.0013 0.0026 0.0025
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0108 0.0107
Trichomonas vaginalis CMGC family protein kinase 0.0042 0.0194 0.1167
Mycobacterium ulcerans DNA polymerase IV 0.0035 0.0157 0.1823
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0102 0.0545 0.0544
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0019 0.0062 0.0373
Trypanosoma cruzi target of rapamycin kinase 3 0.0015 0.0039 0.1935
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0081 0.0399
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0108 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0062 0.3138
Entamoeba histolytica hypothetical protein 0.0066 0.0333 0.2007
Trypanosoma cruzi Flagellar Member 6 0.0019 0.0062 0.3138
Schistosoma mansoni hypothetical protein 0.0022 0.0081 0.0081
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0295 0.1659 0.1659
Brugia malayi conserved hypotetical protein 0.0013 0.0026 0.0025
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 0.1659 1
Echinococcus multilocularis lamin 0.0027 0.0111 0.0111
Schistosoma mansoni intermediate filament proteins 0.0027 0.0111 0.0111
Echinococcus granulosus mitogen activated protein kinase 0.0042 0.0194 0.0194
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.002 0.0072 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0108 0.0107
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0019 0.0064 0.0386
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0108 0.0108
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0026 0.0025
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0019 0.0062 0.0373
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0081 0.0399
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0039 0.0039
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0016 0.0097
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0019 0.0062 0.3138
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0066 0.0333 0.0333
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0039 0.1935
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0108 0.0108
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0019 0.0062 0.0912
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0056
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0008 0.0002 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0072 0.3682
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0081 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0108 0.0107
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0113 0.0608 0.3664
Entamoeba histolytica hypothetical protein 0.0066 0.0333 0.2007
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0081 0.083
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0107 0.0643
Schistosoma mansoni hypothetical protein 0.0033 0.0145 0.0145
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0081 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0071 0.007
Onchocerca volvulus 0.0295 0.1659 0.1637
Echinococcus multilocularis lamin dm0 0.0027 0.0111 0.0111
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0024 0.0094 0.0094
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0011 0.0016 0.0097
Echinococcus granulosus serine protein kinase ATM 0.002 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0295 0.1659 1
Plasmodium vivax hypothetical protein, conserved 0.0295 0.1659 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0068 0.0345 0.0344
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.005 0.024 0.2559
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0071 0.3592
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0016
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0108 0.0108
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0295 0.1659 0.1659
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0092 0.0977
Schistosoma mansoni hypothetical protein 0.0062 0.0313 0.0313
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0019 0.0062 0.0061
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0121 0.0653 0.0652
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0107
Brugia malayi Pre-SET motif family protein 0.017 0.0934 0.0933
Onchocerca volvulus 0.0295 0.1659 0.1637
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0019 0.0062 0.0062
Brugia malayi polk-prov protein 0.0011 0.0017 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0108 0.0107
Brugia malayi nuclear hormone receptor 0.0027 0.0108 0.0107
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0107 0.0107
Echinococcus granulosus intermediate filament protein 0.0027 0.0111 0.0111
Trypanosoma brucei RNA helicase, putative 0.0113 0.0608 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0035 0.0157 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Trypanosoma brucei unspecified product 0.0024 0.0094 0.1446
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0027 0.0107 0.0106
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0235 0.1311 0.1311
Giardia lamblia Kinase, CMGC MAPK 0.0042 0.0194 0.1167
Echinococcus granulosus Smad4 0.0015 0.0039 0.0039
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0015 0.0039 0.0527
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0019 0.0062 0.0062
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0015 0.0039 0.0039
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0019 0.0062 0.0143
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0416
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0017 0.0788
Brugia malayi MH1 domain containing protein 0.0015 0.0039 0.0038
Onchocerca volvulus 0.0027 0.0108 0.0082
Brugia malayi Pax transcription factor protein 2 0.0196 0.1087 0.1086
Echinococcus multilocularis voltage gated potassium channel 0.0037 0.0169 0.0169
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0066 0.0333 0.0333
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0016 0.0097
Echinococcus multilocularis mothers against decapentaplegic 5 0.0015 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0295 0.1659 0.1658
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0108 0.0108
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0015 0.0039 0.0527
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0039 0.0039
Trypanosoma brucei unspecified product 0.0035 0.0157 0.2498
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0071
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0034 0.0153 0.0152
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1659 1
Trichomonas vaginalis adenylate cyclase type III, putative 0.0011 0.0016 0.0097
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0295 0.1659 0.1659
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0009 0.0007 0.0007
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0016 0.0097
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0026 0.0025
Brugia malayi Cytochrome P450 family protein 0.0022 0.0081 0.008
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0015 0.0039 0.0039
Leishmania major DNA polymerase eta, putative 0.0035 0.0157 0.6299
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0097
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0221 0.0221
Trypanosoma cruzi cAMP response protein 1, putative 0.0019 0.0062 0.3138
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0016 0.0097
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0026 0.0025
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0038 0.0037
Brugia malayi Calcitonin receptor-like protein seb-1 0.0091 0.0479 0.0478
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0062 0.0373
Echinococcus granulosus sodium and chloride dependent glycine 0.0295 0.1659 0.1659
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0016 0.0097
Mycobacterium leprae conserved hypothetical protein 0.0019 0.0064 0.0617
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0042 0.0194 0.3106
Loa Loa (eye worm) hypothetical protein 0.174 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0092 0.0091
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0081 0.083
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0081 0.083
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0157 0.2498
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0092 0.0091
Leishmania major cyclic nucleotide-binding protein-like protein 0.0019 0.0062 0.2024
Schistosoma mansoni hypothetical protein 0.0029 0.012 0.012
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1659 1
Toxoplasma gondii hypothetical protein 0.0295 0.1659 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0107
Echinococcus granulosus X box binding protein 1 0.0235 0.1311 0.1311
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0295 0.1659 0.1658
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0023 0.0089 0.0089
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0011 0.0016 0.0015
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0081 0.083
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.024 0.2893
Loa Loa (eye worm) solute carrier family 6 member 4 0.174 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0169 0.0169
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0108 0.0108
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0008 0.0002 0.0001
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0019 0.0062 0.0062
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0019 0.0064 0.0384
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0108 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0107
Echinococcus multilocularis serine protein kinase ATM 0.002 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0552 0.3141 0.314
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Leishmania major phosphopantetheinyl transferase-like protein 0.0019 0.0064 0.2108
Leishmania major hypothetical protein, conserved 0.0021 0.0072 0.2493
Trichomonas vaginalis adenylate cyclase type, putative 0.0011 0.0016 0.0097
Echinococcus granulosus lamin 0.0027 0.0111 0.0111
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Trypanosoma brucei protein kinase A regulatory subunit 0.0019 0.0062 0.0912
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0092 0.0977
Schistosoma mansoni hypothetical protein 0.0011 0.0016 0.0016
Entamoeba histolytica deoxycytidyl transferase, putative 0.0035 0.0157 0.0947
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0157 0.2498
Echinococcus granulosus single minded 2 0.0011 0.0016 0.0016
Trypanosoma brucei chrX additional, unordered contigs 0.0011 0.0017 0.0161
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0039 0.0038
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0026 0.0026
Brugia malayi MH2 domain containing protein 0.0015 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0107
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0092 0.0984
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0019 0.0064 0.0168
Brugia malayi steroid hormone receptor 0.0027 0.0108 0.0107
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0025
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0081 0.083
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0157 0.0156
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0042 0.0194 1
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0016 0.0097
Echinococcus granulosus GPCR family 2 0.0029 0.012 0.012
Onchocerca volvulus 0.0019 0.0062 0.0036
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0039 0.0234
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0295 0.1659 0.1658
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0035 0.0157 0.6299
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0157 0.1438
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0016 0.0097
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0019 0.0062 0.3138
Echinococcus granulosus smad 0.0015 0.0039 0.0039
Plasmodium vivax SET domain protein, putative 0.0024 0.0094 0.0568
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0091 0.0479 0.0478
Giardia lamblia DNA damage repair protein 0.0011 0.0017 0.0101
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.012 0.0119
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013 0.0026 0.0026
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0081 0.0399
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1659 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0081 0.0399
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0015 0.0039 0.0039
Mycobacterium ulcerans regulatory protein 0.0019 0.0062 0.0586
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0019 0.0064 0.061
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0025
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0108 0.0107
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0016 0.0097
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0016 0.0097
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0026 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0157 0.2498
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0029 0.012 0.0936
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0157 0.0156
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0157 0.2498
Leishmania major cytochrome p450-like protein 0.0022 0.0081 0.287
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0019 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0016 0.0097
Schistosoma mansoni voltage-gated potassium channel 0.0132 0.0715 0.0715
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0019 0.0062 0.0062
Entamoeba histolytica protein kinase rad3, putative 0.0008 0.0002 0.001
Schistosoma mansoni nuclear receptor 0.0013 0.0026 0.0026
Onchocerca volvulus 0.0196 0.1087 0.1064
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0029 0.012 0.012
Schistosoma mansoni sodium/chloride dependent transporter 0.0295 0.1659 0.1659

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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