Detailed information for compound 999396

Basic information

Technical information
  • TDR Targets ID: 999396
  • Name: methyl N-[(2S)-1-[[(2S,4S,5S)-5-[[(2S)-3,3-di methyl-2-[2-oxo-3-(phenylmethyl)imidazolidin- 1-yl]butanoyl]amino]-4-hydroxy-6-phenyl-1-(4- pyridin-2-ylphenyl)hexan-2-yl]amino]-3,3-dime thyl-1-oxobutan-2-yl]carbamate
  • MW: 805.016 | Formula: C47H60N6O6
  • H donors: 4 H acceptors: 6 LogP: 7.31 Rotable bonds: 22
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)N[C@@H](C(C)(C)C)C(=O)N[C@H](C[C@@H]([C@@H](NC(=O)[C@H](C(C)(C)C)N1CCN(C1=O)Cc1ccccc1)Cc1ccccc1)O)Cc1ccc(cc1)c1ccccn1
  • InChi: 1S/C47H60N6O6/c1-46(2,3)40(51-44(57)59-7)42(55)49-36(28-33-21-23-35(24-22-33)37-20-14-15-25-48-37)30-39(54)38(29-32-16-10-8-11-17-32)50-43(56)41(47(4,5)6)53-27-26-52(45(53)58)31-34-18-12-9-13-19-34/h8-25,36,38-41,54H,26-31H2,1-7H3,(H,49,55)(H,50,56)(H,51,57)/t36-,38-,39-,40+,41+/m0/s1
  • InChiKey: KMAMPFGXPHTYPQ-KMHPXQNHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl N-[(1S)-1-[[(1S,3S,4S)-4-[[(2S)-3,3-dimethyl-2-[2-oxo-3-(phenylmethyl)imidazolidin-1-yl]butanoyl]amino]-3-hydroxy-5-phenyl-1-[[4-(2-pyridyl)phenyl]methyl]pentyl]carbamoyl]-2,2-dimethyl-propyl]carbamate
  • N-[(1S)-1-[[[(1S,3S,4S)-4-[[(2S)-3,3-dimethyl-1-oxo-2-[2-oxo-3-(phenylmethyl)-1-imidazolidinyl]butyl]amino]-3-hydroxy-5-phenyl-1-[[4-(2-pyridyl)phenyl]methyl]pentyl]amino]-oxomethyl]-2,2-dimethylpropyl]carbamic acid methyl ester
  • N-[(1S)-1-[[(1S,3S,4S)-4-[[(2S)-2-[3-(benzyl)-2-keto-imidazolidin-1-yl]-3,3-dimethyl-butanoyl]amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridyl)benzyl]pentyl]carbamoyl]-2,2-dimethyl-propyl]carbamic acid methyl ester
  • methyl N-[(2S)-1-[[(2S,4S,5S)-5-[[(2S)-3,3-dimethyl-2-[2-oxo-3-(phenylmethyl)imidazolidin-1-yl]butanoyl]amino]-4-hydroxy-6-phenyl-1-(4-pyridin-2-ylphenyl)hexan-2-yl]amino]-3,3-dimethyl-1-oxo-butan-2-yl]carbamate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin D Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References
Homo sapiens renin Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin I Get druggable targets OG5_126885 All targets in OG5_126885
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum Pepsinogen A1, related Get druggable targets OG5_126885 All targets in OG5_126885
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus cathepsin d lysosomal aspartyl protease Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin II Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi aspartyl protease, putative Get druggable targets OG5_126885 All targets in OG5_126885
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium yoelii plasmepsin Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii aspartyl proteinase (eimepsin), putative Get druggable targets OG5_126885 All targets in OG5_126885
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl protease ASP1 Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva cathepsin E, putative Get druggable targets OG5_126885 All targets in OG5_126885
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) aspartic protease BmAsp-2 Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Cathepsin D precursor, putative Get druggable targets OG5_126885 All targets in OG5_126885
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax aspartyl proteinase, putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum ko:K01379 cathepsin D [EC3.4.23.5], putative Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase Get druggable targets OG5_126885 All targets in OG5_126885
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium falciparum plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum Renin, related Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva pepsinogen, putative Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Babesia bovis eukaryotic aspartyl protease family protein Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium hominis aspartyl protease precursor Get druggable targets OG5_126885 All targets in OG5_126885
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Plasmodium falciparum plasmepsin X renin 406 aa 352 aa 26.4 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Plasmodium falciparum plasmepsin X cathepsin D 412 aa 339 aa 28.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei prolyl endopeptidase 0.0175 0.0305 0.0853
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.044 0.0823 0.2306
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.044 0.0823 0.0823
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.1274 0.2457 0.2869
Schistosoma mansoni microtubule-associated protein tau 0.5124 1 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0046 0.0053 0.028
Schistosoma mansoni intermediate filament proteins 0.0054 0.0067 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0004 0.0023
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.044 0.0823 0.2306
Loa Loa (eye worm) papain family cysteine protease containing protein 0.044 0.0823 0.0961
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0162 0.0189
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0078 0.0114 0.0114
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.0114 0.0114
Echinococcus multilocularis expressed protein 0.007 0.0099 0.0099
Toxoplasma gondii peptidase family M13 protein 0.0056 0.0071 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.002 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1842 0.3571 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0078 0.0114 0.0114
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0046 0.0053 0.0062
Plasmodium falciparum serine repeat antigen 6 0.044 0.0823 0.2306
Leishmania major acetyl-CoA synthetase, putative 0.0046 0.0053 0.0149
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0009 0.0025
Trypanosoma cruzi cysteine proteinase, putative 0.1008 0.1937 0.2262
Schistosoma mansoni amine GPCR 0.0078 0.0114 0.0114
Loa Loa (eye worm) cytochrome P450 0.0022 0.0004 0.0005
Echinococcus granulosus sex peptide receptor 0.0078 0.0114 0.0114
Brugia malayi G-protein coupled receptor 0.0078 0.0114 0.0134
Trichomonas vaginalis D-aminoacylase, putative 0.0155 0.0265 0.0742
Schistosoma mansoni cathepsin C 0.044 0.0823 0.0823
Echinococcus granulosus chromobox protein 1 0.0074 0.0107 0.0107
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.004 0.0041 0.0213
Entamoeba histolytica cysteine protease, putative 0.1842 0.3571 1
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.003 0.0021 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1842 0.3571 1
Schistosoma mansoni adenoreceptor 0.0078 0.0114 0.0114
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1842 0.3571 0.3571
Trypanosoma cruzi cysteine peptidase, putative 0.1842 0.3571 0.417
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0067 0.0078
Loa Loa (eye worm) hypothetical protein 0.0118 0.0194 0.0226
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0078 0.0114 0.0114
Trypanosoma cruzi fatty acid elongase, putative 0.002 0.0001 0.0001
Mycobacterium tuberculosis Probable peptidase 0.0175 0.0305 0.1605
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0046 0.0053 0.0062
Entamoeba histolytica cysteine protease, putative 0.044 0.0823 0.2306
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.044 0.0823 0.0823
Plasmodium falciparum plasmepsin I 0.0128 0.0213 0.0596
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0214 0.0382 0.1068
Giardia lamblia Cathepsin B precursor 0.044 0.0823 0.2559
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1842 0.3571 1
Schistosoma mansoni cellular tumor antigen P53 0.0216 0.0385 0.0385
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.0114 0.0114
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0053 0.1745
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 0.0823 0.0823
Echinococcus granulosus neuropeptide receptor 0.0078 0.0114 0.0114
Brugia malayi Cathepsin L-like cysteine proteinase 0.1274 0.2457 0.2869
Trichomonas vaginalis set domain proteins, putative 0.1463 0.2829 0.7921
Toxoplasma gondii prolyl endopeptidase 0.0175 0.0305 0.0853
Loa Loa (eye worm) hypothetical protein 0.0447 0.0838 0.0979
Brugia malayi prolyl oligopeptidase family protein 0.2047 0.3971 0.4638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1842 0.3571 1
Mycobacterium ulcerans hypothetical protein 0.0158 0.0272 0.8934
Onchocerca volvulus 0.0078 0.0114 0.0288
Onchocerca volvulus 0.0046 0.0053 0.0134
Onchocerca volvulus 0.1842 0.3571 0.8991
Entamoeba histolytica cysteine protease, putative 0.1008 0.1937 0.5425
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1842 0.3571 0.417
Plasmodium falciparum serine repeat antigen 5 0.044 0.0823 0.2306
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0053 0.1745
Brugia malayi cahepsin L-like non-peptiedase homolog 0.044 0.0823 0.0961
Brugia malayi Angiotensin-converting enzyme family protein 0.0364 0.0676 0.079
Plasmodium falciparum serine repeat antigen 3 0.044 0.0823 0.2306
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0004 0.0144
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4391 0.8563 0.8563
Trypanosoma cruzi hypothetical protein, conserved 0.0175 0.0305 0.0356
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0078 0.0114 0.0114
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0046 0.0053 0.1745
Brugia malayi hypothetical protein 0.0078 0.0114 0.0134
Echinococcus granulosus cathepsin L cysteine protease 0.1008 0.1937 0.1937
Loa Loa (eye worm) hypothetical protein 0.044 0.0823 0.0961
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0059 0.0077 0.0077
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0114 0.0114
Schistosoma mansoni biogenic amine receptor 0.0078 0.0114 0.0114
Brugia malayi putative neuropeptide receptor 0.0078 0.0114 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1842 0.3571 1
Giardia lamblia Cathepsin B precursor 0.044 0.0823 0.2559
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0214 0.0382 0.0446
Brugia malayi prolyl oligopeptidase family protein 0.0175 0.0305 0.0356
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0128 0.0213 0.0213
Brugia malayi Serotonin receptor 0.0078 0.0114 0.0134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1842 0.3571 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0118 0.0194 0.5
Loa Loa (eye worm) prolyl oligopeptidase 0.0175 0.0305 0.0356
Brugia malayi Dopamine receptor 0.0078 0.0114 0.0134
Plasmodium vivax aspartyl protease, putative 0.003 0.0021 0.006
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0004 0.0023
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.0114 0.0114
Entamoeba histolytica cysteine proteinase, putative 0.1842 0.3571 1
Leishmania major cytochrome p450-like protein 0.0022 0.0004 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0155 0.0265 0.0742
Mycobacterium leprae probable zinc metalloprotease 0.0056 0.0071 0.2215
Giardia lamblia Cathepsin L precursor 0.044 0.0823 0.2559
Loa Loa (eye worm) hypothetical protein 0.0155 0.0265 0.031
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0025 0.0029
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0214 0.0382 0.1068
Entamoeba histolytica cysteine protease, putative 0.1008 0.1937 0.5425
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0214 0.0382 0.0382
Brugia malayi fibroinase precursor 0.044 0.0823 0.0961
Brugia malayi Heterochromatin protein 1 0.0074 0.0107 0.0125
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0041 0.0043 0.0226
Plasmodium vivax aspartyl protease, putative 0.003 0.0021 0.006
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0053 0.028
Entamoeba histolytica cysteine proteinase, putative 0.1008 0.1937 0.5425
Leishmania major 4-coumarate:coa ligase-like protein 0.0158 0.0272 0.0762
Loa Loa (eye worm) hypothetical protein 0.0138 0.0232 0.0271
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0053 0.028
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 0.0823 0.0823
Brugia malayi cathepsin F-like cysteine proteinase 0.044 0.0823 0.0961
Mycobacterium ulcerans acyl-CoA synthetase 0.0158 0.0272 0.8934
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0056 0.0071 0.0083
Echinococcus multilocularis g-protein coupled receptor 0.0078 0.0114 0.0114
Leishmania major cathepsin L-like protease 0.1842 0.3571 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0155 0.0265 0.8701
Plasmodium falciparum plasmepsin VI 0.0128 0.0213 0.0596
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1008 0.1937 0.1937
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0021 0.0004 0.0004
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1662 0.3217 0.9009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0155 0.0265 0.1397
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0053 0.1624
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0004 0.0023
Giardia lamblia Cathepsin L precursor 0.044 0.0823 0.2559
Giardia lamblia Encystation-specific protease 0.044 0.0823 0.2559
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0004 0.0144
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0004 0.0023
Loa Loa (eye worm) hypothetical protein 0.0041 0.0042 0.005
Toxoplasma gondii integral membrane protein, GNS1/SUR4 family protein, putative 0.002 0.0001 0.0003
Brugia malayi chromobox protein homolog 3 0.0041 0.0043 0.0051
Echinococcus multilocularis G-protein coupled receptor, putative 0.0078 0.0114 0.0114
Onchocerca volvulus 0.1842 0.3571 0.8991
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0184 0.0323 0.0323
Onchocerca volvulus 0.0078 0.0114 0.0288
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.4391 0.8563 1
Echinococcus multilocularis orexin receptor type 2 0.0078 0.0114 0.0114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Loa Loa (eye worm) TYRA-2 protein 0.0078 0.0114 0.0134
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0175 0.0305 0.0305
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Onchocerca volvulus 0.0078 0.0114 0.0288
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0025 0.0025
Plasmodium falciparum cysteine proteinase falcipain 1 0.1008 0.1937 0.5425
Brugia malayi prolyl oligopeptidase family protein 0.0819 0.1566 0.1829
Plasmodium falciparum plasmepsin X 0.003 0.0021 0.006
Plasmodium falciparum serine repeat antigen 1 0.044 0.0823 0.2306
Brugia malayi neuropeptide F receptor 0.0078 0.0114 0.0134
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0059 0.0077 0.009
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0078 0.0114 0.0114
Schistosoma mansoni neuropeptide receptor 0.0078 0.0114 0.0114
Brugia malayi Melatonin receptor type 1A 0.0078 0.0114 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0043 0.0121
Mycobacterium ulcerans short chain dehydrogenase 0.0166 0.0288 0.9449
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0162 0.0189
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0097 0.0152 0.0178
Echinococcus granulosus g protein coupled receptor 0.0078 0.0114 0.0114
Entamoeba histolytica cysteine protease, putative 0.1008 0.1937 0.5425
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0046 0.0053 0.0053
Schistosoma mansoni neuropeptide receptor 0.0078 0.0114 0.0114
Mycobacterium tuberculosis Conserved protein 0.0155 0.0265 0.1397
Mycobacterium leprae conserved hypothetical protein 0.0155 0.0265 0.8682
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1008 0.1937 0.1937
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0078 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1662 0.3217 0.9009
Brugia malayi beta-lactamase 0.0155 0.0265 0.031
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0138 0.0232 0.0651
Trypanosoma cruzi cysteine peptidase, putative 0.1842 0.3571 0.417
Loa Loa (eye worm) cysteine protease 0.1842 0.3571 0.417
Loa Loa (eye worm) hypothetical protein 0.044 0.0823 0.0961
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0158 0.0272 0.8934
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Loa Loa (eye worm) hypothetical protein 0.0954 0.1831 0.2138
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0175 0.0305 0.1605
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0158 0.0272 0.8934
Entamoeba histolytica hypothetical protein, conserved 0.0175 0.0305 0.0853
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0068 0.0096 0.0112
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0322 0.0593 0.0593
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0214 0.0382 0.0382
Echinococcus multilocularis cathepsin L cysteine protease 0.1842 0.3571 0.3571
Loa Loa (eye worm) hypothetical protein 0.0118 0.0194 0.0226
Loa Loa (eye worm) hypothetical protein 0.044 0.0823 0.0961
Brugia malayi Protein phosphatase 2C containing protein 0.0103 0.0164 0.0192
Entamoeba histolytica hypothetical protein 0.0112 0.0182 0.0509
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.044 0.0823 0.2306
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0068 0.0096 0.0268
Schistosoma mansoni histamine h1 receptor 0.0078 0.0114 0.0114
Brugia malayi beta-lactamase family protein 0.0155 0.0265 0.031
Mycobacterium ulcerans acyl-CoA synthetase 0.0158 0.0272 0.8934
Entamoeba histolytica cysteine protease, putative 0.1008 0.1937 0.5425
Trypanosoma cruzi major cysteine proteinase, putative 0.044 0.0823 0.0961
Onchocerca volvulus 0.0216 0.0385 0.0968
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.0114 0.0114
Trichomonas vaginalis rotamase, putative 0.0068 0.0096 0.0268
Onchocerca volvulus 0.0078 0.0114 0.0288
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0046 0.0053 0.028
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Mycobacterium ulcerans acyl-CoA synthetase 0.0158 0.0272 0.8934
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0138 0.0232 0.0271
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0078 0.0114 0.0134
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0128 0.0213 0.0249
Onchocerca volvulus Protein phosphatase 1D homolog 0.0103 0.0164 0.0414
Schistosoma mansoni opsin-like receptor 0.0078 0.0114 0.0114
Echinococcus granulosus Dipeptidyl peptidase 9 0.0819 0.1566 0.1566
Echinococcus granulosus p2X purinoceptor 4 0.0044 0.0049 0.0049
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.2047 0.3971 0.3971
Plasmodium falciparum plasmepsin IV 0.0128 0.0213 0.0596
Loa Loa (eye worm) hypothetical protein 0.0056 0.0071 0.0083
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.0114 0.0114
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0004 0.0012
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1008 0.1937 0.1937
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0068 0.0096 0.0268
Onchocerca volvulus 0.0152 0.0259 0.0652
Brugia malayi neuropeptide F receptor 0.0078 0.0114 0.0134
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.0002 0.0002
Onchocerca volvulus 0.0049 0.0058 0.0145
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0078 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0155 0.0265 0.031
Trichomonas vaginalis penicillin-binding protein, putative 0.0155 0.0265 0.0742
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0175 0.0305 1
Trypanosoma brucei cytochrome P450, putative 0.0033 0.0026 0.0073
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0078 0.0114 0.0114
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0026 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0053 0.1745
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0214 0.0382 0.1068
Echinococcus multilocularis sphingosine kinase 1 0.0163 0.0281 0.0281
Onchocerca volvulus 0.003 0.0021 0.0054
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.044 0.0823 0.0823
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.044 0.0823 0.2306
Schistosoma mansoni cathepsin B (C01 family) 0.044 0.0823 0.0823
Schistosoma mansoni alpha-1 adrenergic receptor 0.0078 0.0114 0.0114
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0046 0.0053 0.028
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0046 0.0053 0.1745
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0059 0.0077 0.009
Schistosoma mansoni hypothetical protein 0.007 0.0098 0.0098
Echinococcus multilocularis allatostatin A receptor 0.0078 0.0114 0.0114
Brugia malayi Fatty acid elongation protein 3 0.002 0.0001 0.0001
Echinococcus granulosus somatostatin receptor 0.0078 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Plasmodium falciparum plasmepsin V 0.003 0.0021 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1274 0.2457 0.6881
Brugia malayi cathepsin L-like precursor 0.1274 0.2457 0.2869
Leishmania major 4-coumarate:coa ligase-like protein 0.0158 0.0272 0.0762
Trypanosoma brucei Fatty acid elongase 0.002 0.0001 0.0003
Echinococcus granulosus allatostatin A receptor 0.0078 0.0114 0.0114
Entamoeba histolytica acyl-CoA synthetase, putative 0.0158 0.0272 0.0762
Onchocerca volvulus 0.0078 0.0114 0.0288
Trypanosoma brucei hypothetical protein, conserved 0.0155 0.0265 0.0742
Trypanosoma cruzi prolyl endopeptidase 0.0175 0.0305 0.0356
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0214 0.0382 0.0382
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0742 0.1415 0.3963
Schistosoma mansoni cathepsin S (C01 family) 0.044 0.0823 0.0823
Loa Loa (eye worm) hypothetical protein 0.0046 0.0053 0.0062
Entamoeba histolytica prolyl oligopeptidase family protein 0.0175 0.0305 0.0853
Plasmodium vivax vivapain-3 0.1008 0.1937 0.5425
Echinococcus multilocularis chromobox protein 1 0.0074 0.0107 0.0107
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0046 0.0053 0.028
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0138 0.0232 0.0271
Entamoeba histolytica cysteine proteinase 2 0.1008 0.1937 0.5425
Onchocerca volvulus 0.044 0.0823 0.2073
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0214 0.0382 0.0382
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0107 0.0299
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0046 0.0053 0.0062
Brugia malayi prolyl oligopeptidase family protein 0.0175 0.0305 0.0356
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.0114 0.0114
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0021 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0252 0.0456 0.0532
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0078 0.0114 0.0114
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0078 0.0114 0.0114
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0004 0.0023
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.044 0.0823 0.2306
Onchocerca volvulus 0.1463 0.2829 0.7122
Echinococcus multilocularis prolyl endopeptidase 0.0175 0.0305 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1842 0.3571 1
Onchocerca volvulus 0.1842 0.3571 0.8991
Leishmania major cathepsin L-like protease 0.1842 0.3571 1
Entamoeba histolytica hypothetical protein 0.0112 0.0182 0.0509
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0175 0.0305 1
Trypanosoma cruzi cysteine proteinase, putative 0.1008 0.1937 0.2262
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0155 0.0265 0.1397
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0184 0.0323 0.0906
Brugia malayi Pepsin A precursor 0.003 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0026 0.003
Echinococcus granulosus beta LACTamase domain containing family member 0.0155 0.0265 0.0265
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1842 0.3571 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0164 0.0192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1842 0.3571 1
Toxoplasma gondii peptidylprolyl isomerase 0.0068 0.0096 0.0268
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0114 0.0114
Brugia malayi cytochrome P450 0.0022 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0184 0.0323 0.0378
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0107 0.0125
Onchocerca volvulus 0.0078 0.0114 0.0288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 0.1937 0.5425
Echinococcus multilocularis G protein coupled receptor 139 0.0078 0.0114 0.0114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Brugia malayi Cytochrome P450 family protein 0.0068 0.0095 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.044 0.0823 0.2306
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0569 0.1076 0.1257
Plasmodium vivax vivapain-2 0.1842 0.3571 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1842 0.3571 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0046 0.0053 0.028
Brugia malayi RE15519p 0.0078 0.0114 0.0134
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0051
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0175 0.0305 0.0853
Loa Loa (eye worm) hypothetical protein 0.0056 0.0071 0.0083
Brugia malayi ORL1-like opioid receptor 0.0078 0.0114 0.0134
Brugia malayi Papain family cysteine protease containing protein 0.1842 0.3571 0.417
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0053 0.1745
Brugia malayi Cathepsin L-like precursor 0.0569 0.1076 0.1257
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0031 0.0023 0.0027
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1842 0.3571 0.417
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0025 0.0029
Onchocerca volvulus 0.003 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.0567 0.1073 0.1253
Entamoeba histolytica hypothetical protein 0.044 0.0823 0.2306
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0046 0.0053 0.0149
Echinococcus granulosus hypothetical protein 0.0078 0.0114 0.0114
Leishmania major cytochrome p450-like protein 0.0033 0.0026 0.0073
Echinococcus granulosus p2X purinoceptor 4 0.0044 0.0049 0.0049
Brugia malayi Papain family cysteine protease containing protein 0.044 0.0823 0.0961
Echinococcus multilocularis cysteine protease 0.1842 0.3571 0.3571
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0046 0.0053 0.1745
Plasmodium vivax RNA helicase-1, putative 0.0214 0.0382 0.1068
Echinococcus multilocularis muscleblind protein 0.0447 0.0838 0.0838
Onchocerca volvulus 0.0028 0.0016 0.004
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.0114 0.0134
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0078 0.0114 0.0114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1842 0.3571 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0053 0.0062
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.007 0.0099 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 0.1937 0.5425
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.044 0.0823 0.2306
Brugia malayi AMP-binding enzyme family protein 0.0158 0.0272 0.0318
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0023 0.0023
Echinococcus multilocularis voltage gated potassium channel 0.002 0.0002 0.0002
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.044 0.0823 0.2306
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0029
Echinococcus multilocularis p2X purinoceptor 4 0.0044 0.0049 0.0049
Onchocerca volvulus 0.0155 0.0265 0.0667
Schistosoma mansoni neuropeptide receptor 0.0078 0.0114 0.0114
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0004 0.0144
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0078 0.0114 0.0114
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0004 0.0023
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0569 0.1076 0.1257
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0175 0.0305 0.0853
Giardia lamblia Hypothetical protein 0.044 0.0823 0.2559
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1008 0.1937 0.5425
Loa Loa (eye worm) hypothetical protein 0.0041 0.0042 0.005
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0026 0.0031
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0046 0.0053 0.0053
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0004 0.0144
Echinococcus granulosus lamin dm0 0.0054 0.0067 0.0067
Trichomonas vaginalis antibiotic synthetase, putative 0.0046 0.0053 0.0149
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.0013
Echinococcus granulosus p2X purinoceptor 4 0.0044 0.0049 0.0049
Echinococcus multilocularis cathepsin L 0.044 0.0823 0.0823
Leishmania major hypothetical protein, conserved 0.0155 0.0265 0.0742
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0004 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.1842 0.3571 0.3571
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0128 0.0213 0.0213
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0138 0.0232 0.0651
Echinococcus granulosus cathepsin l1 0.1274 0.2457 0.2457
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0023 0.0023
Giardia lamblia Dipeptidyl-peptidase I precursor 0.044 0.0823 0.2559
Loa Loa (eye worm) hypothetical protein 0.002 0.0002 0.0002
Loa Loa (eye worm) peptidase family M13 containing protein 0.0041 0.0042 0.005
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0046 0.0053 0.1624
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Mycobacterium ulcerans acetyl-CoA synthetase 0.0046 0.0053 0.1745
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0078 0.0114 0.0134
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0021 0.0021
Brugia malayi AKH receptor 0.0078 0.0114 0.0134
Entamoeba histolytica cysteine proteinase 1, putative 0.1008 0.1937 0.5425
Trypanosoma cruzi major cysteine proteinase, putative 0.044 0.0823 0.0961
Mycobacterium ulcerans lipase LipD 0.0155 0.0265 0.8701
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1842 0.3571 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.044 0.0823 0.2306
Schistosoma mansoni P2X receptor subunit 0.0044 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0052
Onchocerca volvulus 0.1842 0.3571 0.8991
Mycobacterium tuberculosis Probable oxidoreductase 0.0166 0.0288 0.1517
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.0043 0.1405
Mycobacterium tuberculosis Conserved protein 0.0163 0.0281 0.1479
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0053 0.028
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0364 0.0676 0.079
Plasmodium vivax acyl-CoA synthetase, putative 0.0118 0.0194 0.0543
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0118 0.0194 0.6361
Echinococcus granulosus voltage gated potassium channel 0.002 0.0002 0.0002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0078 0.0114 0.0134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1842 0.3571 1
Entamoeba histolytica cysteine protease, putative 0.1008 0.1937 0.5425
Echinococcus multilocularis p2X purinoceptor 4 0.0044 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0128 0.0213 0.0249
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0114 0.0114
Schistosoma mansoni myosin xvIII 0.0078 0.0114 0.0114
Giardia lamblia Cathepsin L precursor 0.044 0.0823 0.2559
Plasmodium falciparum fatty acid elongation protein, GNS1/SUR4 family, putative 0.002 0.0001 0.0003
Toxoplasma gondii hypothetical protein 0.0175 0.0305 0.0853
Loa Loa (eye worm) hypothetical protein 0.0954 0.1831 0.2138
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0053 0.0062
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0569 0.1076 0.1257
Schistosoma mansoni cathepsin F (C01 family) 0.1274 0.2457 0.2457
Trichomonas vaginalis esterase, putative 0.0155 0.0265 0.0742
Schistosoma mansoni amine GPCR 0.0078 0.0114 0.0114
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0004 0.0144
Brugia malayi follicle stimulating hormone receptor 0.0078 0.0114 0.0134
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0004 0.0023
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.044 0.0823 0.2306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1842 0.3571 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0009 0.001
Brugia malayi cathepsin Z-like cysteine proteinase 0.044 0.0823 0.0961
Giardia lamblia Cysteine protease 0.044 0.0823 0.2559
Schistosoma mansoni neuropeptide receptor 0.0078 0.0114 0.0114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1842 0.3571 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0029 0.0019 0.0052
Mycobacterium ulcerans hypothetical protein 0.0155 0.0265 0.8701
Echinococcus granulosus cathepsin l1 0.1842 0.3571 0.3571
Loa Loa (eye worm) hypothetical protein 0.1842 0.3571 0.417
Entamoeba histolytica cysteine protease, putative 0.1008 0.1937 0.5425
Brugia malayi Cathepsin L-like precursor 0.1842 0.3571 0.417
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0004 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1842 0.3571 1
Brugia malayi hypothetical protein 0.0567 0.1073 0.1253
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0053 0.1745
Giardia lamblia Cathepsin L precursor 0.044 0.0823 0.2559
Leishmania major cathepsin L-like protease 0.1842 0.3571 1
Trypanosoma cruzi oligopeptidase b 0.0175 0.0305 0.0356
Echinococcus granulosus cathepsin b 0.4391 0.8563 0.8563
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0175 0.0305 0.0853
Toxoplasma gondii GNS1/SUR4 family protein 0.002 0.0001 0.0003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0155 0.0265 0.031
Echinococcus granulosus cathepsin L cysteine proteinase 0.1842 0.3571 0.3571
Loa Loa (eye worm) hypothetical protein 0.0155 0.0265 0.031
Echinococcus granulosus endothelin converting enzyme 1 0.0056 0.0071 0.0071
Echinococcus granulosus neuropeptide s receptor 0.0529 0.0999 0.0999
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0021 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0052 0.0063 0.0074
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.007 0.0099 0.0115
Plasmodium vivax unspecified product 0.1008 0.1937 0.5425
Leishmania major hypothetical protein, conserved 0.0024 0.0009 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.044 0.0823 0.2306
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0013 0.0013
Entamoeba histolytica cysteine proteinase, putative 0.1274 0.2457 0.6881
Plasmodium vivax serine-repeat antigen (SERA) 0.044 0.0823 0.2306
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.044 0.0823 0.2306
Onchocerca volvulus 0.0078 0.0114 0.0288
Toxoplasma gondii propionate-CoA ligase 0.0046 0.0053 0.0149
Onchocerca volvulus Prolyl endopeptidase homolog 0.0175 0.0305 0.0767
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1842 0.3571 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.2047 0.3971 0.3971
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Brugia malayi Muscleblind-like protein 0.0447 0.0838 0.0979
Loa Loa (eye worm) cathepsin B 0.1662 0.3217 0.3757
Brugia malayi hypothetical protein 0.0152 0.0259 0.0303
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Echinococcus granulosus cysteine protease 0.1008 0.1937 0.1937
Loa Loa (eye worm) hypothetical protein 0.0158 0.0272 0.0318
Plasmodium vivax unspecified product 0.044 0.0823 0.2306
Plasmodium falciparum acyl-CoA synthetase 0.0118 0.0194 0.0543
Leishmania major cysteine peptidase A (CPA) 0.1842 0.3571 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.044 0.0823 0.2306
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.0305 0.0853
Mycobacterium leprae Probable lipase LipE 0.0155 0.0265 0.8682
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0158 0.0272 0.1434
Onchocerca volvulus 0.0078 0.0114 0.0288
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0004 0.0005
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0053 0.1745
Echinococcus granulosus cathepsin L 0.1008 0.1937 0.1937
Echinococcus multilocularis neuropeptide FF receptor 2 0.0078 0.0114 0.0114
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0046 0.0053 0.028
Schistosoma mansoni lamin 0.0054 0.0067 0.0067
Brugia malayi cathepsin L-like cysteine proteinase 0.044 0.0823 0.0961
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0041 0.0043 0.012
Trypanosoma cruzi oligopeptidase b 0.0175 0.0305 0.0356
Entamoeba histolytica acyl-CoA synthetase, putative 0.0158 0.0272 0.0762
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0041 0.0043 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1842 0.3571 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.0114 0.0114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Entamoeba histolytica hypothetical protein, conserved 0.0163 0.0281 0.0786
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0175 0.0305 0.0356
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0078 0.0114 0.0114
Brugia malayi hypothetical protein 0.0078 0.0114 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1842 0.3571 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0023 0.0023
Trichomonas vaginalis rotamase, putative 0.007 0.0099 0.0277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1842 0.3571 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0078 0.0114 0.0114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1842 0.3571 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.0114 0.0114
Plasmodium vivax serine-repeat antigen (SERA) 0.044 0.0823 0.2306
Onchocerca volvulus 0.0158 0.0272 0.0685
Brugia malayi Dopamine receptor protein 2 0.0078 0.0114 0.0134
Brugia malayi AMP-binding enzyme family protein 0.0158 0.0272 0.0318
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0053 0.0062
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0004 0.0144
Brugia malayi G protein-coupled receptor F59B2.13 0.0078 0.0114 0.0134
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0078 0.0114 0.0134
Brugia malayi Cathepsin L-like precursor 0.1842 0.3571 0.417
Echinococcus multilocularis neuropeptide receptor 0.0078 0.0114 0.0114
Brugia malayi Serotonin receptor 0.0078 0.0114 0.0134
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0175 0.0305 0.0853
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1842 0.3571 0.3571
Loa Loa (eye worm) hypothetical protein 0.044 0.0823 0.0961
Plasmodium vivax acetyl-CoA synthetase, putative 0.0046 0.0053 0.0149
Mycobacterium ulcerans beta-lactamase 0.0155 0.0265 0.8701
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0046 0.0053 0.1745
Echinococcus multilocularis beta LACTamase domain containing family member 0.0155 0.0265 0.0265
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.044 0.0823 0.2306
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0155 0.0265 0.0265
Onchocerca volvulus 0.0078 0.0114 0.0288
Schistosoma mansoni aldehyde dehydrogenase 0.0041 0.0043 0.0043
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0819 0.1566 0.1566
Mycobacterium tuberculosis Probable esterase LipL 0.0155 0.0265 0.1397
Toxoplasma gondii hypothetical protein 0.0033 0.0027 0.0075
Leishmania major acetyl-CoA synthetase, putative 0.0046 0.0053 0.0149
Trypanosoma cruzi cruzipain precursor, putative 0.0569 0.1076 0.1257
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0197 0.0347 0.0347
Onchocerca volvulus Cathepsin L homolog 0.1842 0.3571 0.8991
Plasmodium vivax hypothetical protein, conserved 0.0175 0.0305 0.0853
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1842 0.3571 1
Brugia malayi prolyl oligopeptidase family protein 0.0175 0.0305 0.0356
Trypanosoma cruzi cysteine peptidase, putative 0.0569 0.1076 0.1257
Trypanosoma cruzi cysteine peptidase, putative 0.1842 0.3571 0.417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1274 0.2457 0.6881
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.044 0.0823 0.2306
Echinococcus multilocularis cathepsin b 0.4391 0.8563 0.8563
Loa Loa (eye worm) aspartyl protease 6 0.003 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1842 0.3571 1
Plasmodium vivax SET domain protein, putative 0.0184 0.0323 0.0906
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0031 0.0023 0.0027
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0046 0.0053 0.1745
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0025
Entamoeba histolytica cysteine protease, putative 0.1008 0.1937 0.5425
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0025
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0046 0.0053 0.1745
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0046 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Trypanosoma cruzi fatty acid elongase, putative 0.002 0.0001 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.0043 0.1405
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.0114 0.0114
Giardia lamblia Cathepsin B precursor 0.1662 0.3217 1
Schistosoma mansoni chromobox protein 0.0074 0.0107 0.0107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1842 0.3571 1
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0175 0.0305 0.0356
Loa Loa (eye worm) hypothetical protein 0.0569 0.1076 0.1257
Onchocerca volvulus 0.0054 0.0067 0.0169
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Toxoplasma gondii aspartyl protease ASP1 0.0128 0.0213 0.0596
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0053 0.028
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.0114 0.0114
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0021 0.0021
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0004 0.0144
Onchocerca volvulus 0.0197 0.0347 0.0874
Loa Loa (eye worm) hypothetical protein 0.0102 0.0162 0.0189
Echinococcus granulosus neuropeptide receptor 0.0078 0.0114 0.0114
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0078 0.0114 0.0114
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0175 0.0305 0.0853
Giardia lamblia Dipeptidyl-peptidase I precursor 0.044 0.0823 0.2559
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0178 0.031 0.031
Onchocerca volvulus Neuropeptide F receptor homolog 0.0078 0.0114 0.0288
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.0114 0.0114
Plasmodium vivax aspartyl protease, putative 0.003 0.0021 0.006
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.0114 0.0114
Leishmania major oligopeptidase b 0.0175 0.0305 0.0853
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0214 0.0382 0.1068
Mycobacterium tuberculosis Conserved protein 0.0155 0.0265 0.1397
Schistosoma mansoni hypothetical protein 0.0078 0.0114 0.0114
Trypanosoma cruzi cysteine peptidase, putative 0.1008 0.1937 0.2262
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0009 0.0025
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.0095 0.0111
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0098 0.0115
Brugia malayi aspartic protease BmAsp-2, identical 0.003 0.0021 0.0025
Onchocerca volvulus Cathepsin L homolog 0.044 0.0823 0.2073
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.0043 0.1405
Brugia malayi hypothetical protein 0.0078 0.0114 0.0134
Echinococcus multilocularis microtubule associated protein 2 0.5124 1 1
Giardia lamblia Cathepsin B precursor 0.044 0.0823 0.2559
Loa Loa (eye worm) hypothetical protein 0.0155 0.0265 0.031
Brugia malayi cathepsin L precursor 0.044 0.0823 0.0961
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0128 0.0213 0.0213
Entamoeba histolytica cysteine proteinase, putative 0.1008 0.1937 0.5425
Schistosoma mansoni amine GPCR 0.0078 0.0114 0.0114
Echinococcus granulosus prolyl endopeptidase 0.0175 0.0305 0.0305
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0046 0.0053 0.0149
Onchocerca volvulus 0.0078 0.0114 0.0288
Schistosoma mansoni cathepsin D (A01 family) 0.0378 0.0702 0.0702
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0155 0.0265 0.1397
Plasmodium falciparum plasmepsin VIII, putative 0.003 0.0021 0.006
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0004 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0112 0.0181 0.0955
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0078 0.0114 0.0114
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.2047 0.3971 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Onchocerca volvulus 0.0046 0.0053 0.0134
Brugia malayi Pre-SET motif family protein 0.1286 0.2481 0.2897
Schistosoma mansoni biogenic amine receptor 0.0078 0.0114 0.0114
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0819 0.1566 0.1829
Leishmania major cathepsin L-like protease 0.1842 0.3571 1
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0114 0.0114
Echinococcus multilocularis cathepsin L cysteine protease 0.1842 0.3571 0.3571
Brugia malayi GnHR receptor homolog 0.0078 0.0114 0.0134
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0158 0.0272 0.8934
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.0114 0.0114
Echinococcus granulosus tumor protein p63 0.1473 0.2848 0.2848
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0053 0.1745
Plasmodium vivax plasmepsin IV, putative 0.0128 0.0213 0.0596
Loa Loa (eye worm) hypothetical protein 0.0447 0.0838 0.0979
Loa Loa (eye worm) beta-lactamase 0.0155 0.0265 0.031
Echinococcus granulosus GPCR family 2 0.0032 0.0025 0.0025
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0214 0.0382 0.1186
Brugia malayi aspartic protease BmAsp-1, identical 0.003 0.0021 0.0025
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0049 0.0124
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0114 0.0114
Onchocerca volvulus 0.0054 0.0067 0.0169
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0078 0.0114 0.0134
Plasmodium falciparum plasmepsin VII 0.003 0.0021 0.006
Echinococcus multilocularis acylamino acid releasing enzyme 0.0175 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0155 0.0265 0.031
Echinococcus granulosus lamin 0.0054 0.0067 0.0067
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0013 0.0013
Plasmodium falciparum serine repeat antigen 7 0.044 0.0823 0.2306
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.0114 0.0114
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 0.0823 0.0823
Entamoeba histolytica hypothetical protein 0.0112 0.0182 0.0509
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0021 0.0004 0.001
Brugia malayi hypothetical protein 0.0078 0.0114 0.0134
Loa Loa (eye worm) hypothetical protein 0.044 0.0823 0.0961
Entamoeba histolytica cysteine protease, putative 0.1008 0.1937 0.5425
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0819 0.1566 0.4386
Entamoeba histolytica cysteine proteinase, putative 0.1008 0.1937 0.5425
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0138 0.0232 0.0271
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0078 0.0114 0.0134
Echinococcus multilocularis lamin 0.0054 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0162 0.0189
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0004 0.0144
Giardia lamblia Cathepsin L-like protease 0.044 0.0823 0.2559
Loa Loa (eye worm) papain family cysteine protease containing protein 0.044 0.0823 0.0961
Loa Loa (eye worm) hypothetical protein 0.0053 0.0065 0.0076
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.0114 0.0114
Brugia malayi Cathepsin L-like precursor 0.1274 0.2457 0.2869
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.044 0.0823 0.2306
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.4391 0.8563 0.8563
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.0114 0.0114
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1662 0.3217 0.3217
Giardia lamblia Cathepsin L precursor 0.044 0.0823 0.2559
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.0114 0.0114
Brugia malayi sulfakinin receptor protein 0.0078 0.0114 0.0134
Leishmania major fatty acid elongase, putative 0.002 0.0001 0.0003
Onchocerca volvulus 0.1274 0.2457 0.6187
Entamoeba histolytica cysteine proteinase, putative 0.1842 0.3571 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0205 0.0363 0.0424
Echinococcus granulosus histone lysine methyltransferase setb 0.0184 0.0323 0.0323
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.044 0.0823 0.2306
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0078 0.0114 0.0134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4391 0.8563 0.8563
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Trypanosoma cruzi cysteine protease, putative 0.1008 0.1937 0.2262
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.044 0.0823 0.0961
Echinococcus granulosus dro:myosuppressin receptor 0.0078 0.0114 0.0114
Toxoplasma gondii cathepsin CPC2 0.044 0.0823 0.2306
Trypanosoma brucei prolyl oligopeptidase, putative 0.0175 0.0305 0.0853
Mycobacterium ulcerans hypothetical protein 0.0163 0.0281 0.9213
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0214 0.0382 0.096
Brugia malayi Cathepsin L-like precursor 0.1842 0.3571 0.417
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0046 0.0053 0.0149
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0068 0.0096 0.0112
Plasmodium falciparum long chain fatty acid elongation enzyme, putative 0.002 0.0001 0.0003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.0114 0.0114
Brugia malayi Papain family cysteine protease containing protein 0.044 0.0823 0.0961
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0214 0.0382 0.1068
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.044 0.0823 0.2306
Schistosoma mansoni P2X receptor subunit 0.0044 0.0049 0.0049
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0078 0.0114 0.0134
Loa Loa (eye worm) hypothetical protein 0.0041 0.0042 0.005
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0078 0.0114 0.0114
Entamoeba histolytica cysteine protease, putative 0.044 0.0823 0.2306
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0053 0.1745
Onchocerca volvulus 0.1842 0.3571 0.8991
Echinococcus granulosus neuropeptide receptor A26 0.0529 0.0999 0.0999
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0175 0.0305 0.0853
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0004 0.0023
Onchocerca volvulus Cathepsin L homolog 0.1842 0.3571 0.8991
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0028 0.0017 0.0017
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0046 0.0053 0.0062
Onchocerca volvulus 0.0078 0.0114 0.0288
Onchocerca volvulus 0.0078 0.0114 0.0288
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0046 0.0053 0.0149
Giardia lamblia Cathepsin B precursor 0.044 0.0823 0.2559
Plasmodium falciparum cysteine proteinase falcipain 3 0.1842 0.3571 1
Entamoeba histolytica cysteine protease, putative 0.1008 0.1937 0.5425
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0004 0.0144
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Echinococcus granulosus tm gpcr rhodopsin 0.0322 0.0593 0.0593
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0046 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0118 0.0194 0.0226
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Brugia malayi hypothetical protein 0.003 0.0021 0.0025
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0025
Echinococcus granulosus cathepsin L 0.044 0.0823 0.0823
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0021 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0155 0.0265 0.031
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0004 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0114 0.0114
Echinococcus granulosus tachykinin peptides receptor 99D 0.0078 0.0114 0.0114
Plasmodium vivax serine-repeat antigen (SERA), putative 0.044 0.0823 0.2306
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0004 0.0144
Brugia malayi Eukaryotic aspartyl protease family protein 0.003 0.0021 0.0025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0182 0.0182
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.0017 0.0017
Leishmania major cytochrome p450-like protein 0.0022 0.0004 0.0012
Loa Loa (eye worm) fibroinase 0.1842 0.3571 0.417
Trypanosoma cruzi cruzipain precursor, putative 0.1842 0.3571 0.417
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1842 0.3571 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0046 0.0053 0.028
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.0114 0.0114
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0078 0.0114 0.0114
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0175 0.0305 0.0356
Brugia malayi hypothetical protein 0.003 0.0021 0.0025
Entamoeba histolytica cysteine protease, putative 0.044 0.0823 0.2306
Brugia malayi hypothetical protein 0.0078 0.0114 0.0134
Mycobacterium ulcerans hypothetical protein 0.0138 0.0232 0.7626
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0004 0.0023
Plasmodium falciparum eukaryotic initiation factor 4A 0.0214 0.0382 0.1068
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.0114 0.0134
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0214 0.0382 0.2011
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Onchocerca volvulus 0.1842 0.3571 0.8991
Echinococcus granulosus g protein coupled receptor 0.0078 0.0114 0.0114
Schistosoma mansoni sphingoid long chain base kinase 0.0163 0.0281 0.0281
Mycobacterium ulcerans zinc metalloprotease 0.0056 0.0071 0.2327
Giardia lamblia Cysteine protease 0.044 0.0823 0.2559
Trichomonas vaginalis penicillin-binding protein, putative 0.0155 0.0265 0.0742
Entamoeba histolytica papain family cysteine protease domain containing protein 0.044 0.0823 0.2306
Plasmodium falciparum serine repeat antigen 8 0.044 0.0823 0.2306
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0155 0.0265 0.031
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0021 0.0021
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0158 0.0272 0.1434
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0004 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0023 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0052
Toxoplasma gondii cathepsin CPC1 0.044 0.0823 0.2306
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Schistosoma mansoni acetyl-CoA synthetase 0.0046 0.0053 0.0053
Trypanosoma brucei oligopeptidase b 0.0175 0.0305 0.0853
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0112 0.0181 0.0955
Loa Loa (eye worm) hypothetical protein 0.0216 0.0385 0.0449
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0004 0.0023
Giardia lamblia Cysteine protease 0.044 0.0823 0.2559
Mycobacterium ulcerans hypothetical protein 0.0108 0.0173 0.5694
Echinococcus granulosus eukaryotic initiation factor 4A 0.0214 0.0382 0.0382
Brugia malayi G-protein coupled receptor 0.0078 0.0114 0.0134
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0004 0.0144
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0033 0.0026 0.0858
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Loa Loa (eye worm) melatonin receptor type 1A 0.0078 0.0114 0.0134
Echinococcus granulosus 7TM GPCR rhodopsin 0.0078 0.0114 0.0114
Brugia malayi Cytochrome P450 family protein 0.0022 0.0004 0.0005
Echinococcus granulosus peptide allatostatin:somatostatin 0.0078 0.0114 0.0114
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0025 0.0029
Plasmodium falciparum plasmepsin III 0.003 0.0021 0.006
Plasmodium vivax aspartyl proteinase, putative 0.0128 0.0213 0.0596
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 0.0823 0.0823
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0112 0.0181 0.0955
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.044 0.0823 0.2306
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0046 0.0053 0.0149
Entamoeba histolytica cysteine protease, putative 0.1008 0.1937 0.5425
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0819 0.1566 0.1829
Echinococcus multilocularis somatostatin receptor 0.0078 0.0114 0.0114
Leishmania major fatty acid elongase, putative 0.002 0.0001 0.0003
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0078 0.0114 0.0114
Brugia malayi hypothetical protein 0.0078 0.0114 0.0134
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0004 0.0144
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0029 0.0019 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.044 0.0823 0.2306
Loa Loa (eye worm) hypothetical protein 0.044 0.0823 0.0961
Entamoeba histolytica prolyl oligopeptidase family protein 0.0175 0.0305 0.0853
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0021 0.0021
Loa Loa (eye worm) aspartic protease BmAsp-1 0.003 0.0021 0.0025
Schistosoma mansoni amine GPCR 0.0078 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0118 0.0194 0.0226
Schistosoma mansoni cathepsin D (A01 family) 0.0378 0.0702 0.0702
Schistosoma mansoni lamin 0.0054 0.0067 0.0067
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.0425 0.0496
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0175 0.0305 0.0305
Echinococcus granulosus G protein coupled receptor 139 0.0078 0.0114 0.0114
Onchocerca volvulus 0.0032 0.0026 0.0065
Brugia malayi hypothetical protein 0.0078 0.0114 0.0134
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0004 0.0144
Leishmania major cathepsin L-like protease 0.1842 0.3571 1
Echinococcus multilocularis fmrfamide receptor 0.0078 0.0114 0.0114
Brugia malayi larval opioid receptor 0.0078 0.0114 0.0134
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0078 0.0114 0.0134
Brugia malayi cathepsin F-like cysteine proteinase 0.0569 0.1076 0.1257
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0175 0.0305 0.0356
Plasmodium vivax aspartyl proteinase, putative 0.003 0.0021 0.006
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.044 0.0823 0.2306
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Schistosoma mansoni amine GPCR 0.0078 0.0114 0.0114
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0009 0.0025
Trypanosoma cruzi cysteine peptidase, putative 0.1842 0.3571 0.417
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0043 0.0121
Entamoeba histolytica papain family cysteine protease domain containing protein 0.044 0.0823 0.2306
Schistosoma mansoni P2X receptor subunit 0.0044 0.0049 0.0049
Giardia lamblia Dipeptidyl-peptidase I precursor 0.044 0.0823 0.2559
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0175 0.0305 0.0853
Plasmodium vivax serine-repeat antigen (SERA), putative 0.044 0.0823 0.2306
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0158 0.0272 0.8934
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0099 0.0277
Schistosoma mansoni growth hormone secretagogue receptor 0.0078 0.0114 0.0114
Echinococcus granulosus fmrfamide receptor 0.0078 0.0114 0.0114
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0004 0.0023
Onchocerca volvulus Cathepsin F homolog 0.1842 0.3571 0.8991
Loa Loa (eye worm) oxidoreductase 0.0046 0.0053 0.0062
Echinococcus multilocularis fmrfamide receptor 0.0078 0.0114 0.0114
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0118 0.0194 0.1021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0023 0.0023
Echinococcus granulosus orexin receptor type 2 0.0078 0.0114 0.0114
Plasmodium falciparum serine repeat antigen 2 0.044 0.0823 0.2306
Leishmania major 4-coumarate:coa ligase-like protein 0.0158 0.0272 0.0762
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.044 0.0823 0.2306
Onchocerca volvulus 0.0155 0.0265 0.0667
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0087 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1008 0.1937 0.5425
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0021 0.0004 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.044 0.0823 0.2306
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0009 0.0025
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0029 0.0019 0.0022
Entamoeba histolytica cysteine protease, putative 0.1008 0.1937 0.5425
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0026 0.0031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0108 0.0173 0.0914
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0128 0.0213 0.0596
Brugia malayi eukaryotic initiation factor 4A 0.0214 0.0382 0.0446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1842 0.3571 1
Schistosoma mansoni opsin-like receptor 0.0078 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0112 0.0182 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0184 0.0323 0.0323
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.0114 0.0114
Leishmania major mitochondrial DNA polymerase beta 0.0205 0.0363 0.1018
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0138 0.0232 0.0651
Loa Loa (eye worm) hypothetical protein 0.1274 0.2457 0.2869
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0046 0.0053 0.1624
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.044 0.0823 0.2306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1842 0.3571 1
Echinococcus granulosus muscleblind protein 0.0447 0.0838 0.0838
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0025
Toxoplasma gondii preprocathepsin c precursor, putative 0.044 0.0823 0.2306
Echinococcus multilocularis musashi 0.0054 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.4391 0.8563 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Onchocerca volvulus 0.0078 0.0114 0.0288
Brugia malayi Tachykinin-like peptides receptor 99D 0.0078 0.0114 0.0134
Loa Loa (eye worm) peptidase family M13 containing protein 0.0041 0.0042 0.005
Giardia lamblia Hypothetical protein 0.044 0.0823 0.2559
Brugia malayi hypothetical protein 0.0112 0.0182 0.0212
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Brugia malayi Cathepsin L-like precursor 0.1274 0.2457 0.2869
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0004 0.0023
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Entamoeba histolytica cysteine proteinase, putative 0.1008 0.1937 0.5425
Schistosoma mansoni hypothetical protein 0.0022 0.0004 0.0004
Entamoeba histolytica cysteine protease, putative 0.044 0.0823 0.2306
Echinococcus multilocularis neuropeptide receptor 0.0078 0.0114 0.0114
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0067 0.0078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Brugia malayi hypothetical protein 0.0024 0.0009 0.001
Schistosoma mansoni sphingosine kinase A B 0.0163 0.0281 0.0281
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0097 0.0152 0.0426
Schistosoma mansoni cytochrome P450 0.0022 0.0004 0.0004
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0004 0.0144
Brugia malayi hypothetical protein 0.0078 0.0114 0.0134
Echinococcus multilocularis 0.0022 0.0004 0.0004
Brugia malayi hypothetical protein 0.0078 0.0114 0.0134
Loa Loa (eye worm) hypothetical protein 0.0158 0.0272 0.0318
Toxoplasma gondii aspartyl protease ASP3 0.003 0.0021 0.006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0051 0.0062 0.0173
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0175 0.0305 0.0853
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0138 0.0232 0.0651
Onchocerca volvulus 0.0155 0.0265 0.0667
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0029 0.0019 0.0022
Echinococcus multilocularis endothelin converting enzyme 1 0.0056 0.0071 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0184 0.0323 0.0323
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0819 0.1566 0.4386
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0019
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.1008 0.1937 0.2262
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.0017 0.0017
Entamoeba histolytica acyl-coA synthetase, putative 0.0158 0.0272 0.0762
Onchocerca volvulus 0.0046 0.0053 0.0134
Leishmania major cathepsin L-like protease 0.1842 0.3571 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0138 0.0232 0.0651
Leishmania major fatty acid elongase, putative 0.002 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1842 0.3571 1
Schistosoma mansoni P2X receptor subunit 0.0044 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0078 0.0114 0.0114
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0046 0.0053 0.0062
Loa Loa (eye worm) fatty acid elongation protein 3 0.002 0.0001 0.0001
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0004 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1842 0.3571 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0214 0.0382 0.1068
Brugia malayi Papain family cysteine protease containing protein 0.044 0.0823 0.0961
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0175 0.0305 0.0305
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0182 0.0182
Giardia lamblia Cathepsin B precursor 0.044 0.0823 0.2559
Giardia lamblia Cathepsin B precursor 0.1662 0.3217 1
Schistosoma mansoni memapsin-2 (A01 family) 0.003 0.0021 0.0021
Trypanosoma brucei cysteine peptidase C (CPC) 0.1662 0.3217 0.9009
Loa Loa (eye worm) CYP4Cod1 0.0033 0.0026 0.0031
Leishmania major cathepsin L-like protease 0.1842 0.3571 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.001
Mycobacterium tuberculosis Probable hydrolase 0.0155 0.0265 0.1397
Trichomonas vaginalis D-aminoacylase, putative 0.0155 0.0265 0.0742
Brugia malayi Peptidase family M13 containing protein 0.0056 0.0071 0.0083
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0056 0.0071 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Trichomonas vaginalis D-aminoacylase, putative 0.0155 0.0265 0.0742
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0114 0.0114
Brugia malayi Cathepsin L-like precursor 0.1842 0.3571 0.417
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0182 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1842 0.3571 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0158 0.0272 0.8919
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0214 0.0382 0.0446
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0114 0.0114
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0053 0.1745
Entamoeba histolytica cysteine protease, putative 0.1008 0.1937 0.5425
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.0114 0.0114
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0097 0.0152 0.0426
Brugia malayi AMP-binding enzyme family protein 0.0158 0.0272 0.0318
Loa Loa (eye worm) hypothetical protein 0.0041 0.0042 0.005
Echinococcus granulosus chromobox protein 1 0.0074 0.0107 0.0107
Schistosoma mansoni chromobox protein 0.0074 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0152 0.0259 0.0303
Loa Loa (eye worm) hypothetical protein 0.0214 0.0382 0.0446
Brugia malayi cathepsin Z-like cysteine proteinase 0.044 0.0823 0.0961
Echinococcus granulosus cathepsin b 0.4391 0.8563 0.8563
Toxoplasma gondii ABC1 family protein 0.0155 0.0265 0.0742
Echinococcus multilocularis cysteine protease 0.1842 0.3571 0.3571
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.002 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.044 0.0823 0.2306
Schistosoma mansoni rotamase 0.007 0.0099 0.0099
Brugia malayi Papain family cysteine protease containing protein 0.1008 0.1937 0.2262
Schistosoma mansoni cathepsin F (C01 family) 0.1842 0.3571 0.3571
Mycobacterium tuberculosis Conserved protein 0.0155 0.0265 0.1397
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Mycobacterium ulcerans esterase/lipase LipP 0.0155 0.0265 0.8701
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Brugia malayi hypothetical protein 0.0078 0.0114 0.0134
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0021 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0004 0.0023
Entamoeba histolytica hypothetical protein 0.0112 0.0182 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.044 0.0823 0.2306
Toxoplasma gondii cathepsin CPL 0.1842 0.3571 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0004 0.0144
Loa Loa (eye worm) hypothetical protein 0.0054 0.0067 0.0078
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0158 0.0272 0.8919
Schistosoma mansoni biogenic amine receptor 0.0078 0.0114 0.0114
Trichomonas vaginalis antibiotic synthetase, putative 0.0046 0.0053 0.0149
Loa Loa (eye worm) ctsf protein 0.1842 0.3571 0.417
Echinococcus multilocularis neuropeptide receptor A26 0.0529 0.0999 0.0999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1842 0.3571 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0138 0.0232 0.0651
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0078 0.0114 0.0114
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0078 0.0114 0.0134
Loa Loa (eye worm) hypothetical protein 0.1274 0.2457 0.2869
Plasmodium falciparum serine repeat antigen 9 0.044 0.0823 0.2306
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Loa Loa (eye worm) prolyl oligopeptidase 0.2047 0.3971 0.4638
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0046 0.0053 0.0062
Echinococcus granulosus neuropeptide FF receptor 2 0.0078 0.0114 0.0114
Echinococcus multilocularis chromobox protein 1 0.0074 0.0107 0.0107
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0163 0.0281 0.0328
Plasmodium falciparum plasmepsin IX 0.003 0.0021 0.006
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0184 0.0323 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1842 0.3571 1
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0002 0.0002
Onchocerca volvulus 0.0078 0.0114 0.0288
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0004 0.0023
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0035 0.0031 0.0036
Plasmodium falciparum serine repeat antigen 4 0.044 0.0823 0.2306
Schistosoma mansoni opsin-like receptor 0.0078 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1842 0.3571 1
Echinococcus multilocularis cathepsin b 0.4391 0.8563 0.8563
Echinococcus multilocularis neuropeptide s receptor 0.0529 0.0999 0.0999
Brugia malayi Cathepsin L-like precursor 0.1842 0.3571 0.417
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0021 0.0021
Echinococcus multilocularis dro:myosuppressin receptor 0.0078 0.0114 0.0114
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 0.0823 0.0823
Giardia lamblia Alanyl dipeptidyl peptidase 0.0175 0.0305 0.0947
Onchocerca volvulus 0.1842 0.3571 0.8991
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0028 0.0017 0.0017
Brugia malayi beta-lactamase family protein 0.0155 0.0265 0.031
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0205 0.0363 0.0424
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1286 0.2481 0.2897
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.2047 0.3971 0.3971
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Echinococcus multilocularis GPCR, family 2 0.0032 0.0025 0.0025
Onchocerca volvulus 0.0078 0.0114 0.0288
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Loa Loa (eye worm) hypothetical protein 0.0155 0.0265 0.031
Echinococcus multilocularis cathepsin L 0.1008 0.1937 0.1937
Toxoplasma gondii cathepsin B 0.1662 0.3217 0.9009
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.0114 0.0114
Leishmania major cathepsin L-like protease 0.1842 0.3571 1
Entamoeba histolytica cysteine protease, putative 0.044 0.0823 0.2306
Echinococcus granulosus sphingosine kinase 1 0.0163 0.0281 0.0281
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1842 0.3571 1
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0175 0.0305 0.0305
Schistosoma mansoni neprilysin-2 (M13 family) 0.0028 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0118 0.0194 0.0226
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4391 0.8563 0.8563
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0138 0.0232 0.0651
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0078 0.0114 0.0288
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0004 0.0023
Echinococcus granulosus serotonin receptor 0.0078 0.0114 0.0114
Echinococcus granulosus g-protein coupled receptor 0.0078 0.0114 0.0114
Plasmodium vivax GNS1/SUR4 domain containing protein 0.002 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0569 0.1076 0.1257
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0114 0.0114
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0068 0.0096 0.0268
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0015
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0021 0.0004 0.001
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0004 0.0012
Entamoeba histolytica cysteine protease, putative 0.1008 0.1937 0.5425
Plasmodium vivax plasmepsin V, putative 0.003 0.0021 0.006
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0004 0.0005
Giardia lamblia Alanyl dipeptidyl peptidase 0.0175 0.0305 0.0947
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.044 0.0823 0.2306
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0051 0.0062 0.0173
Brugia malayi G protein-coupled receptor 0.0078 0.0114 0.0134
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0067 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1842 0.3571 1
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.0114 0.0134
Schistosoma mansoni hypothetical protein 0.0078 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1842 0.3571 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.044 0.0823 0.2306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.044 0.0823 0.2306
Onchocerca volvulus 0.0078 0.0114 0.0288
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0988 0.1898 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.1842 0.3571 0.3571
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0078 0.0114 0.0114
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0059 0.0077 0.0077
Plasmodium falciparum peptidase, putative 0.0175 0.0305 0.0853
Brugia malayi GNS1/SUR4 family protein 0.002 0.0001 0.0001
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1274 0.2457 0.2869
Schistosoma mansoni cathepsin s 0.0569 0.1076 0.1076
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.0115
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0018 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0049 0.0139
Echinococcus multilocularis sex peptide receptor 0.0078 0.0114 0.0114
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0026 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0184 0.0323 0.0323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1842 0.3571 1
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0087 0.0087
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0056 0.0071 0.0374
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0114 0.0114
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0046 0.0053 0.0149
Plasmodium vivax unspecified product 0.0569 0.1076 0.3013
Echinococcus multilocularis tumor protein p63 0.1473 0.2848 0.2848
Echinococcus granulosus intermediate filament protein 0.0054 0.0067 0.0067
Echinococcus granulosus expressed protein 0.007 0.0099 0.0099
Plasmodium vivax vivapain-2 0.1842 0.3571 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.044 0.0823 0.2559
Echinococcus multilocularis lamin dm0 0.0054 0.0067 0.0067
Entamoeba histolytica prolyl oligopeptidase family protein 0.0175 0.0305 0.0853
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0004 0.0144
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0049 0.0139
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0009 0.001
Echinococcus granulosus 7tm_1 domain containing protein 0.0078 0.0114 0.0114
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0155 0.0265 0.0265
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0041 0.0043 0.0043
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0205 0.0363 0.1018
Brugia malayi MH2 domain containing protein 0.0236 0.0425 0.0496
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0043 0.0109
Treponema pallidum ATP-dependent RNA helicase 0.0214 0.0382 1
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0002 0.0002
Echinococcus multilocularis p2X purinoceptor 4 0.0044 0.0049 0.0049
Echinococcus granulosus g protein coupled receptor 0.0078 0.0114 0.0114
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0819 0.1566 0.1566
Giardia lamblia Cathepsin B precursor 0.1662 0.3217 1
Echinococcus multilocularis muscleblind protein 1 0.0447 0.0838 0.0838
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0018 0.0022
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.0002 0.0002
Trypanosoma cruzi fatty acid elongase, putative 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0214 0.0382 0.1068
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0078 0.0114 0.0114
Brugia malayi cathepsin B-like cysteine proteinase 0.4391 0.8563 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0025 0.0025
Brugia malayi putative neuropeptide receptor NPR1 0.0078 0.0114 0.0134
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.0114 0.0134
Trypanosoma cruzi fatty acid elongase, putative 0.002 0.0001 0.0001
Toxoplasma gondii aspartyl protease 0.003 0.0021 0.006
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0107 0.0299
Brugia malayi Pre-SET motif family protein 0.0184 0.0323 0.0378
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0004 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.044 0.0823 0.2306
Mycobacterium tuberculosis Probable lipase LipD 0.0155 0.0265 0.1397
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Loa Loa (eye worm) GNS1/SUR4 family protein 0.002 0.0001 0.0001
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.002 0.0002 0.0002
Brugia malayi intermediate filament protein 0.0054 0.0067 0.0078
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0056 0.0071 0.0083
Brugia malayi Dopamine receptor protein 1 0.0078 0.0114 0.0134
Onchocerca volvulus 0.0078 0.0114 0.0288
Giardia lamblia Cysteine protease 0.044 0.0823 0.2559
Plasmodium falciparum plasmepsin II 0.0128 0.0213 0.0596
Entamoeba histolytica cysteine protease, putative 0.044 0.0823 0.2306
Loa Loa (eye worm) hypothetical protein 0.0158 0.0272 0.0318
Giardia lamblia Cathepsin L-like protease 0.044 0.0823 0.2559
Brugia malayi Cytochrome P450 family protein 0.0033 0.0026 0.0031
Echinococcus multilocularis serotonin receptor 0.0078 0.0114 0.0114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0114 0.0114
Schistosoma mansoni neuropeptide f receptor 76f 0.0078 0.0114 0.0114
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.0425 0.0496
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0053 0.0062
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0046 0.0053 0.1745
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0004 0.0144
Echinococcus multilocularis serotonin receptor 0.0078 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1662 0.3217 0.3757
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0128 0.0213 0.0596
Echinococcus granulosus acylamino acid releasing enzyme 0.0175 0.0305 0.0305
Trypanosoma cruzi hypothetical protein, conserved 0.0155 0.0265 0.031
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0175 0.0305 0.0853
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Schistosoma mansoni hypothetical protein 0.0078 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0078 0.0114 0.0134
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0819 0.1566 0.4386
Mycobacterium tuberculosis Probable lipase LipE 0.0155 0.0265 0.1397
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0009 0.0025
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0052
Giardia lamblia Cathepsin L precursor 0.044 0.0823 0.2559
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0004 0.0144
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0025
Brugia malayi Papain family cysteine protease containing protein 0.1008 0.1937 0.2262
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0046 0.0053 0.0149
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0214 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0175 0.0305 0.0356
Plasmodium vivax vivapain-1 0.1008 0.1937 0.5425
Leishmania major eukaryotic initiation factor 4a, putative 0.0214 0.0382 0.1068
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.044 0.0823 0.0823
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1842 0.3571 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0004 0.0144
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.0013
Toxoplasma gondii aldehyde dehydrogenase 0.0041 0.0043 0.012
Brugia malayi Cathepsin L-like precursor 0.1842 0.3571 0.417
Schistosoma mansoni aldehyde dehydrogenase 0.0041 0.0043 0.0043
Brugia malayi Cytochrome P450 family protein 0.0033 0.0026 0.0031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0112 0.0181 0.0955

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) > 10 uM Inhibition of CYP1A2 assessed as phenacetin O-deethylation ChEMBL. 19323562
IC50 (ADMET) > 10 uM Inhibition of CYP2C9 assessed as Tolbutamide hydroxylation ChEMBL. 19323562
IC50 (ADMET) > 10 uM Inhibition of CYP2C19 assessed as S-mephenytion hydroxylation ChEMBL. 19323562
IC50 (ADMET) > 10 uM Inhibition of CYP2D6 assessed as dextromethorphan O-demethylation ChEMBL. 19323562
Ki (ADMET) = 18 nM Inhibition of CYP3A4 assessed as midazolam 1'- hydroxylation ChEMBL. 19323562
Ki (binding) > 4 uM Inhibition of renin ChEMBL. 19323562
Ki (binding) = 4.3 uM Inhibition of cathepsin D ChEMBL. 19323562
PB (ADMET) = 99.66 % Protein binding in human plasma by equilibrium dialysis ChEMBL. 19323562

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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