Detailed information for compound 1347095

Basic information

Technical information
  • TDR Targets ID: 1347095
  • Name: methyl 5-[(2-chlorobenzoyl)amino]-2H-1,2,4-tr iazole-3-carboxylate
  • MW: 280.667 | Formula: C11H9ClN4O3
  • H donors: 2 H acceptors: 4 LogP: 1.97 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1n[nH]c(n1)NC(=O)c1ccccc1Cl
  • InChi: 1S/C11H9ClN4O3/c1-19-10(18)8-13-11(16-15-8)14-9(17)6-4-2-3-5-7(6)12/h2-5H,1H3,(H2,13,14,15,16,17)
  • InChiKey: HTNXZTLBVIXWCB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[[(2-chlorophenyl)-oxomethyl]amino]-2H-1,2,4-triazole-3-carboxylic acid methyl ester
  • 5-[(2-chlorobenzoyl)amino]-2H-1,2,4-triazole-3-carboxylic acid methyl ester
  • methyl 5-[(2-chlorophenyl)carbonylamino]-2H-1,2,4-triazole-3-carboxylate
  • MLS000564035
  • SMR000151648
  • Oprea1_784050
  • T0503-0173
  • ZINC03179704
  • ST5163772
  • Oprea1_606354

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens coagulation factor XII (Hageman factor) Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis smad 0.0026 0.0062 0.0094
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0024 0.0046 0.0073
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0515 0.0809
Echinococcus multilocularis lysine specific demethylase 6a 0.0088 0.0448 0.0691
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0023 0.0000014746
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0012
Schistosoma mansoni smad1 5 8 and 0.0026 0.0062 0.0062
Brugia malayi RNA binding protein 0.0063 0.0294 0.0471
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0151 0.0218
Treponema pallidum phosphoglycerate kinase 0.1014 0.6238 1
Schistosoma mansoni smad1 5 8 and 0.0026 0.0062 0.0062
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0024 0.0046 0.007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0332 0.1972 0.1972
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0041 0.0153 0.0245
Echinococcus multilocularis jumonji domain containing 1A 0.0088 0.0448 0.0691
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0041 0.0153 0.0236
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0317 0.1878 0.1878
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0008
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0024 0.0046 0.0073
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0023 0.0000014746
Toxoplasma gondii 6-phosphofructokinase 0.0099 0.0516 0.0817
Onchocerca volvulus 0.0024 0.0046 0.0132
Schistosoma mansoni ap endonuclease 0.006 0.0274 0.0274
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0136 0.0748 0.1199
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.1052 0.6473 1
Trypanosoma cruzi metacaspase, putative 0.0083 0.0418 0.0653
Toxoplasma gondii LsmAD domain-containing protein 0.0082 0.0412 0.0651
Echinococcus multilocularis PHD finger protein rhinoceros 0.0273 0.1602 0.2474
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0151 0.0223
Brugia malayi F/Y-rich N-terminus family protein 0.0093 0.0482 0.0773
Trypanosoma brucei polo-like protein kinase 0.0297 0.1753 0.2797
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0023 0.0000014746
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0099 0.0515 0.0803
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0046 0.0062
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0024 0.0046 0.007
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0151 0.0241
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0274 0.0422
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0024 0.0046 0.007
Trypanosoma cruzi metacaspase, putative 0.0083 0.0418 0.0653
Trypanosoma cruzi DNA damage repair protein, putative 0.0089 0.0457 0.0715
Echinococcus granulosus Protein son of sevenless 0.002 0.0023 0.0034
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0024 0.0046 0.0046
Echinococcus multilocularis bromo adjacent y domain containing 1 0.0019 0.0015 0.0023
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0041 0.0153 0.0236
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0278 0.1632 0.1632
Loa Loa (eye worm) hypothetical protein 0.0068 0.0325 0.0521
Entamoeba histolytica hypothetical protein 0.0171 0.0969 0.1522
Loa Loa (eye worm) hypothetical protein 0.0871 0.5341 0.8561
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0297 0.1753 0.2708
Loa Loa (eye worm) hypothetical protein 0.0027 0.0067 0.0107
Echinococcus granulosus 6 phosphofructokinase 0.0366 0.2185 0.3375
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0233 0.036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0111 0.0171
Schistosoma mansoni jumonji domain containing protein 0.0088 0.0448 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.2013 0.321
Brugia malayi MH2 domain containing protein 0.0026 0.0062 0.0099
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.005 0.0048
Trypanosoma cruzi small ubiquitin protein, putative 0.0278 0.1632 0.2603
Brugia malayi hypothetical protein 0.0082 0.0412 0.066
Leishmania major metacaspase, putative 0.0083 0.0418 0.0653
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.002 0.0023 0.0018
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0274 0.0423
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0099 0.0515 0.0809
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.02 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0515 0.0803
Trypanosoma brucei phosphoglycerate kinase 0.1014 0.6238 1
Onchocerca volvulus 0.0031 0.0091 0.0262
Echinococcus granulosus dna polymerase kappa 0.0317 0.1881 0.2905
Brugia malayi hypothetical protein 0.0099 0.0515 0.0826
Brugia malayi mbt repeat family protein 0.0264 0.1547 0.248
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.0207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0099 0.0515 0.0803
Trichomonas vaginalis chromobox protein, putative 0.0604 0.3671 0.5874
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0099 0.0515 0.0803
Giardia lamblia DNA damage repair protein 0.0089 0.0457 0.0664
Brugia malayi Kringle domain containing protein 0.0039 0.0141 0.0227
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0264 0.1547 0.4461
Trichomonas vaginalis hypothetical protein 0.0099 0.0515 0.0803
Echinococcus granulosus PHD finger protein rhinoceros 0.0273 0.1602 0.2474
Onchocerca volvulus 0.0024 0.0046 0.0132
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0024 0.0046 0.007
Schistosoma mansoni hypothetical protein 0.0058 0.0262 0.0262
Echinococcus multilocularis 0.0027 0.0069 0.0105
Onchocerca volvulus 0.0058 0.0262 0.0755
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0297 0.1753 0.281
Brugia malayi Protein cec-1. 0.0099 0.0515 0.0826
Loa Loa (eye worm) MBCTL1 0.03 0.1775 0.2846
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.013 0.0201
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0297 0.1753 0.2708
Schistosoma mansoni z-protein (S1r protein) 0.0028 0.0073 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0418 0.0647
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0294 0.0471
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0024 0.0046 0.007
Brugia malayi PHD-finger family protein 0.0032 0.0096 0.0154
Brugia malayi M-phase phosphoprotein, mpp8 0.0099 0.0515 0.0826
Brugia malayi Cell death protein 3 precursor 0.0114 0.0611 0.0979
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0024 0.0046 0.007
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0069 0.0086
Trypanosoma brucei DNA polymerase IV, putative 0.0317 0.1881 0.3002
Leishmania major phosphoglycerate kinase C, glycosomal 0.1014 0.6238 1
Brugia malayi PHD-finger family protein 0.0273 0.1602 0.2568
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.02 0.0308
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0136 0.0748 0.1155
Echinococcus granulosus Smad4 0.0026 0.0062 0.0094
Trichomonas vaginalis chromobox protein, putative 0.0364 0.2173 0.3468
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0262 0.042
Echinococcus granulosus geminin 0.0532 0.3221 0.4976
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0515 0.0803
Trypanosoma cruzi DNA polymerase kappa, putative 0.0317 0.1881 0.3002
Schistosoma mansoni hypothetical protein 0.0074 0.0359 0.0359
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0024 0.0046 0.0073
Schistosoma mansoni chromobox protein 0.0099 0.0515 0.0515
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0028 0.0073 0.0118
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.0025 0.0028
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0023 0.0000014746
Loa Loa (eye worm) hypothetical protein 0.0171 0.0969 0.1553
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0022 0.0036
Giardia lamblia Histone acetyltransferase GCN5 0.0085 0.0428 0.0616
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0151 0.0218
Brugia malayi Pre-SET motif family protein 0.0037 0.013 0.0209
Loa Loa (eye worm) mbt repeat family protein 0.0264 0.1547 0.248
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Onchocerca volvulus 0.0163 0.0917 0.2644
Trichomonas vaginalis phosphofructokinase, putative 0.0366 0.2185 0.3486
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1683 0.2599
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0089 0.0455 0.0712
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0011 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0366 0.2185 0.3486
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Echinococcus granulosus metastasis associated protein 1 mta1 0.0019 0.0015 0.0023
Trypanosoma brucei protein tyrosine phosphatase 1 0.0024 0.0046 0.0055
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.005 0.0069
Echinococcus granulosus cpg binding protein 0.0144 0.0796 0.1228
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0024 0.0046 0.007
Giardia lamblia Phosphoglycerate kinase 0.1014 0.6238 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0297 0.1753 0.281
Schistosoma mansoni dep domain containing protein 0.0028 0.0073 0.0073
Schistosoma mansoni dishevelled 0.0028 0.0073 0.0073
Echinococcus granulosus Chromobox protein 3 0.0099 0.0515 0.0795
Trichomonas vaginalis phosphofructokinase, putative 0.0366 0.2185 0.3486
Onchocerca volvulus 0.0039 0.0141 0.0408
Schistosoma mansoni pcd6 interacting protein-related 0.0024 0.0046 0.0046
Plasmodium vivax DNA repair protein REV1, putative 0.0089 0.0457 0.0715
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0136 0.0748 0.1155
Plasmodium falciparum metacaspase-like protein 0.0083 0.0418 0.0653
Echinococcus multilocularis ubiquitin 0.0171 0.0969 0.1496
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0019 0.0015 0.0015
Schistosoma mansoni bromodomain containing protein 0.0069 0.0328 0.0328
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0023 0.0000014746
Mycobacterium ulcerans phosphoglycerate kinase 0.1014 0.6238 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0366 0.2185 0.349
Schistosoma mansoni chromobox protein 0.0604 0.3671 0.3671
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0001 0.0001
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0153 0.0235
Brugia malayi MH2 domain containing protein 0.0026 0.0062 0.0099
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0024 0.0046 0.007
Brugia malayi N-terminal motif family protein 0.002 0.0023 0.0037
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0023 0.0000014746
Trypanosoma brucei DNA damage repair protein, putative 0.0089 0.0457 0.0715
Schistosoma mansoni kinase 0.0151 0.0841 0.0841
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0233 0.036
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0083 0.0418 0.0645
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0012
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0027 0.0069 0.0092
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0099 0.0515 0.0795
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0227
Brugia malayi polybromodomain protein 0.0029 0.0078 0.0124
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0028 0.0034
Echinococcus granulosus tissue type plasminogen activator 0.0039 0.0141 0.0218
Entamoeba histolytica recQ family DNA helicase 0.0021 0.0028 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.013 0.013
Trypanosoma cruzi PAB1-binding protein , putative 0.0082 0.0412 0.0643
Entamoeba histolytica hypothetical protein 0.002 0.0023 0.0000014746
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0294 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0206 0.1185 0.1885
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0099 0.0515 0.0826
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Trypanosoma brucei DNA polymerase IV, putative 0.031 0.1836 0.293
Trichomonas vaginalis dullard protein, putative 0.0027 0.0069 0.0086
Onchocerca volvulus Serine\/threonine kinase homolog 0.0297 0.1753 0.5056
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0274 0.0423
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0041 0.0153 0.0236
Brugia malayi ELM2 domain containing protein 0.0019 0.0015 0.0024
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0573 0.0918
Echinococcus granulosus caspase 2 0.0114 0.0611 0.0943
Loa Loa (eye worm) RasGEF domain-containing protein 0.002 0.0023 0.0037
Leishmania major modification methylase-like protein 0.0084 0.042 0.0656
Mycobacterium ulcerans hypothetical protein 0.0089 0.0457 0.0702
Onchocerca volvulus 0.0018 0.0008 0.0022
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.002 0.0023 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.02 0.02
Onchocerca volvulus 0.0024 0.0046 0.0132
Onchocerca volvulus 0.0265 0.1556 0.4486
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0027 0.0069 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0515 0.0803
Brugia malayi TAR-binding protein 0.0063 0.0294 0.0471
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0024 0.0046 0.0073
Schistosoma mansoni cpg binding protein 0.0144 0.0796 0.0796
Echinococcus granulosus chromobox protein 2 0.0099 0.0515 0.0795
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0011 0.0018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0274 0.0422
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0099 0.0515 0.0803
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0294 0.0294
Schistosoma mansoni hypothetical protein 0.0034 0.0111 0.0111
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0027 0.0069 0.0092
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0288 0.17 0.2625
Echinococcus multilocularis bloom syndrome protein 0.0099 0.0516 0.0797
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0023 0.0000014746
Echinococcus granulosus SAM and MBT domain containing protein 0.0264 0.1547 0.2389
Brugia malayi hypothetical protein 0.0028 0.0073 0.0118
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0151 0.0232
Brugia malayi isocitrate dehydrogenase 0.0018 0.0011 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0136 0.0748 0.0748
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0024 0.0046 0.007
Loa Loa (eye worm) hypothetical protein 0.0099 0.0515 0.0826
Echinococcus granulosus disco interacting protein 2 0.0163 0.0917 0.1415
Onchocerca volvulus 0.0024 0.0046 0.0132
Echinococcus multilocularis segment polarity protein dishevelled 0.0028 0.0073 0.0112
Echinococcus granulosus chromobox protein 1 0.0604 0.3671 0.567
Echinococcus multilocularis SAM and MBT domain containing protein 0.0264 0.1547 0.2389
Plasmodium vivax JmjC domain containing protein 0.0088 0.0448 0.0701
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0126 0.019
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.02 0.0321
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0011 0.0017
Loa Loa (eye worm) 6-phosphofructokinase 0.0366 0.2185 0.3502
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0027 0.0069 0.0092
Schistosoma mansoni phd finger protein 0.002 0.0025 0.0025
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0362 0.0563
Brugia malayi Associated with TFs and helicases family protein 0.0099 0.0515 0.0826
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.002 0.0023 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.02 0.02
Mycobacterium ulcerans thioesterase TesA 0.002 0.0025 0.0007
Brugia malayi PHD-finger family protein 0.0091 0.0466 0.0747
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.0362 0.058
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0515 0.0809
Schistosoma mansoni protein tyrosine phosphatase 0.0024 0.0046 0.0046
Schistosoma mansoni chromobox protein 0.0099 0.0515 0.0515
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0095 0.049 0.0776
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.002 0.0023 0.0018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0111 0.0178
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0274 0.0422
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0027 0.0069 0.0069
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.089 0.5461 0.875
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0233 0.0233
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0099 0.0515 0.0792
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0294 0.0294
Leishmania major hypothetical protein, conserved 0.0082 0.0412 0.0643
Leishmania major DNA polymerase eta, putative 0.0509 0.3078 0.4924
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.0362 0.0559
Loa Loa (eye worm) hypothetical protein 0.004 0.0151 0.0241
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0111 0.0178
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0099 0.0515 0.0803
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0418 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0515 0.0803
Trypanosoma brucei DNA polymerase kappa, putative 0.0317 0.1881 0.3002
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0099 0.0516 0.0809
Trichomonas vaginalis phosphoglycerate kinase, putative 0.1014 0.6238 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Leishmania major small ubiquitin protein, putative 0.0278 0.1632 0.2603
Trichomonas vaginalis ubiquitin, putative 0.0171 0.0969 0.1532
Echinococcus multilocularis Protein son of sevenless 0.002 0.0023 0.0034
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.1014 0.6238 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0024 0.0046 0.007
Loa Loa (eye worm) runx1 0.0054 0.0233 0.0374
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0024 0.0046 0.0055
Echinococcus multilocularis GPCR, family 2 0.0034 0.0111 0.0171
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0037 0.0128 0.0197
Loa Loa (eye worm) SMO-1 protein 0.0278 0.1632 0.2617
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0088 0.0448 0.0701
Brugia malayi SET domain containing protein 0.0101 0.0531 0.0851
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.1753 0.2793
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.0418 0.0647
Echinococcus multilocularis polybromo 1 0.0029 0.0081 0.0124
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0101 0.0527 0.0813
Echinococcus multilocularis histone acetyltransferase MYST2 0.03 0.1775 0.2742
Brugia malayi GATA zinc finger family protein 0.0019 0.0015 0.0024
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0011 0.0007
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0023 0.0000014746
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0024 0.0046 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0418 0.0647
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.0418 0.0647
Loa Loa (eye worm) hypothetical protein 0.0091 0.0466 0.0747
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0019 0.0015 0.0015
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0024 0.0046 0.0046
Trichomonas vaginalis phosphofructokinase, putative 0.0099 0.0516 0.0804
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0295 0.1745 0.2784
Brugia malayi acetyltransferase, GNAT family protein 0.0317 0.1878 0.301
Echinococcus granulosus bromo adjacent y domain containing 1 0.0019 0.0015 0.0023
Echinococcus granulosus arginine glutamic acid dipeptide RE repeats 0.0019 0.0015 0.0023
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0088 0.0448 0.0448
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.0362 0.058
Onchocerca volvulus 0.0024 0.0046 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.0816 0.1287
Schistosoma mansoni polybromo-1 0.0029 0.0081 0.0081
Loa Loa (eye worm) jmjC domain-containing protein 0.0332 0.1972 0.3162
Echinococcus multilocularis MAM 0.0018 0.0008 0.0011
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.03 0.1775 0.2846
Onchocerca volvulus 0.0028 0.0073 0.0211
Echinococcus multilocularis disco interacting protein 2 0.0163 0.0917 0.1415
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0069 0.0086
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0024 0.0046 0.007
Plasmodium vivax hypothetical protein, conserved 0.0089 0.0455 0.0712
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0011 0.0008
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.006 0.0063
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0274 0.0422
Schistosoma mansoni survival motor neuron protein 0.0058 0.0262 0.0262
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0053 0.0228 0.0348
Schistosoma mansoni phosphatidylserine receptor 0.0088 0.0448 0.0448
Loa Loa (eye worm) 6-phosphofructokinase 0.0366 0.2185 0.3502
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0028 0.0026
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5107 0.789
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0011 0.0011
Schistosoma mansoni caspase-3 (C14 family) 0.0083 0.0418 0.0418
Trypanosoma brucei metacaspase 5, putative 0.0083 0.0418 0.0653
Schistosoma mansoni protein tyrosine phosphatase 0.0024 0.0046 0.0046
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.006 0.0084
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0024 0.0046 0.0046
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0601 0.3653 0.5642
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0306 0.0472
Leishmania major hypothetical protein, conserved 0.0039 0.0141 0.0209
Trypanosoma brucei Metacaspase-4 0.0083 0.0418 0.0653
Trypanosoma cruzi DNA polymerase eta, putative 0.0509 0.3078 0.4924
Brugia malayi jmjC domain containing protein 0.0088 0.0448 0.0718
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.006 0.0084
Entamoeba histolytica hypothetical protein 0.0099 0.0515 0.0792
Schistosoma mansoni SET domain protein 0.0037 0.0129 0.0129
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Loa Loa (eye worm) hypothetical protein 0.03 0.1775 0.2846
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0274 0.0428
Onchocerca volvulus 0.0024 0.0046 0.0132
Brugia malayi jmjC domain containing protein 0.0088 0.0448 0.0718
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.0418 0.0647
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5107 0.5107
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0024 0.0046 0.007
Echinococcus granulosus polybromo 1 0.0029 0.0081 0.0124
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0151 0.0232
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0024 0.0046 0.007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Loa Loa (eye worm) hypothetical protein 0.0428 0.2573 0.4124
Echinococcus multilocularis tissue type plasminogen activator 0.0039 0.0141 0.0218
Brugia malayi MH2 domain containing protein 0.0385 0.2307 0.3698
Onchocerca volvulus Alhambra homolog 0.0273 0.1602 0.462
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0099 0.0515 0.0792
Loa Loa (eye worm) hypothetical protein 0.0074 0.0359 0.0575
Toxoplasma gondii hypothetical protein 0.0358 0.2136 0.3418
Onchocerca volvulus 0.0142 0.0784 0.2261
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0095 0.049 0.0768
Loa Loa (eye worm) RasGEF domain-containing protein 0.002 0.0023 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0012
Entamoeba histolytica dual specificity protein phosphatase, putative 0.058 0.3522 0.563
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0067 0.0316 0.0489
Plasmodium falciparum heterochromatin protein 1 0.0099 0.0515 0.0809
Brugia malayi jmjC domain containing protein 0.0088 0.0448 0.0718
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0024 0.0046 0.007
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0153 0.0235
Brugia malayi phosphofructokinase 0.0366 0.2185 0.3502
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Plasmodium falciparum small ubiquitin-related modifier 0.0278 0.1632 0.2603
Loa Loa (eye worm) hypothetical protein 0.0467 0.282 0.452
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.0418 0.0647
Schistosoma mansoni hypothetical protein 0.0034 0.0111 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0317 0.1881 0.3002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0111 0.0171
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0073 0.0112
Plasmodium falciparum phd finger protein, putative 0.0273 0.1602 0.2554
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Schistosoma mansoni phosphoglycerate kinase 0.1014 0.6238 0.6238
Brugia malayi Protein-tyrosine phosphatase 1 0.0024 0.0046 0.0073
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Loa Loa (eye worm) hypothetical protein 0.0265 0.1556 0.2494
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0418 0.0647
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0099 0.0515 0.0803
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0084 0.042 0.042
Trypanosoma cruzi phosphoglycerate kinase, putative 0.1014 0.6238 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0366 0.2185 0.3481
Schistosoma mansoni hypothetical protein 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0114 0.0611 0.0979
Brugia malayi hypothetical protein 0.0024 0.0046 0.0073
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0317 0.1881 0.2998
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0571 0.3468 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0083 0.0418 0.0645
Brugia malayi hypothetical protein 0.0031 0.0091 0.0146
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0083 0.0418 0.066
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.0146
Loa Loa (eye worm) RasGEF domain-containing protein 0.002 0.0023 0.0037
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0274 0.0417
Trypanosoma brucei hypothetical protein, conserved 0.0089 0.0457 0.0715
Trypanosoma brucei DNA polymerase kappa, putative 0.0206 0.1185 0.1885
Schistosoma mansoni bromo adjacent homology domain containing 0.0019 0.0015 0.0015
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0366 0.2185 0.3473
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0084 0.042 0.0664
Schistosoma mansoni jumonji/arid domain-containing protein 0.0332 0.1972 0.1972
Trichomonas vaginalis chromobox protein, putative 0.0099 0.0515 0.0803
Schistosoma mansoni phosphoglycerate kinase 0.1014 0.6238 0.6238
Echinococcus granulosus segment polarity protein dishevelled 0.0028 0.0073 0.0112
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.0025 0.0007
Leishmania major tyrosine specific protein phosphatase, putative 0.0024 0.0046 0.0055
Trypanosoma cruzi metacaspase, putative 0.0083 0.0418 0.0653
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0027 0.0069 0.011
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0115 0.0176
Brugia malayi hypothetical protein 0.0024 0.0046 0.0073
Trichomonas vaginalis phosphofructokinase, putative 0.0099 0.0516 0.0804
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0023 0.0000014746
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0126 0.017
Trypanosoma brucei chrX additional, unordered contigs 0.0089 0.0457 0.0715
Mycobacterium ulcerans polyketide synthase 0.0026 0.006 0.0063
Brugia malayi hypothetical protein 0.0428 0.2573 0.4124
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0011 0.0017
Giardia lamblia Sentrin 0.0278 0.1632 0.2562
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.004 0.0065
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0151 0.0232
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0118
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0372 0.2225 0.3555
Brugia malayi Phosphoglycerate kinase 0.1014 0.6238 1
Brugia malayi Bromodomain containing protein 0.0283 0.1665 0.2668
Trichomonas vaginalis chromobox protein, putative 0.0604 0.3671 0.5874
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0037
Trichomonas vaginalis dullard protein, putative 0.0027 0.0069 0.0086
Echinococcus granulosus histone acetyltransferase MYST2 0.03 0.1775 0.2742
Trichomonas vaginalis ras GTP exchange factor, putative 0.002 0.0023 0.0012
Plasmodium falciparum DNA repair protein REV1, putative 0.0089 0.0457 0.0715
Echinococcus granulosus segment polarity protein dishevelled 0.0028 0.0073 0.0112
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0573 0.0918
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0053 0.0228 0.0348
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0024 0.0046 0.007
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0027 0.0069 0.0069
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0024 0.0046 0.0046
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0372 0.2225 0.3555
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0151 0.0151
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0372 0.2225 0.3555
Loa Loa (eye worm) hypothetical protein 0.0108 0.0573 0.0918
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.0187 0.03
Loa Loa (eye worm) CHromoDomain protein family member 0.0101 0.0527 0.0844
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0052 0.0084
Schistosoma mansoni hypothetical protein 0.0532 0.3221 0.3221
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.1753 0.2793
Trichomonas vaginalis chromobox protein, putative 0.0364 0.2173 0.3468
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.1753 0.2793
Onchocerca volvulus 0.0171 0.0969 0.2794
Schistosoma mansoni DNA helicase recq1 0.0041 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0871 0.5341 0.8561
Schistosoma mansoni hypothetical protein 0.0089 0.0455 0.0455
Entamoeba histolytica phosphoglycerate kinase, putative 0.1014 0.6238 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0095 0.049 0.0776
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.0418 0.0647
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.0362 0.0559
Trypanosoma brucei phosphoglycerate kinase 0.1014 0.6238 1
Echinococcus granulosus metastasis associated protein MTA1 0.0019 0.0015 0.0023
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0062 0.0094
Brugia malayi Protein kinase domain containing protein 0.0039 0.0141 0.0227
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.013 0.0199
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0151 0.0206
Trichomonas vaginalis set domain proteins, putative 0.0287 0.1693 0.2697
Echinococcus multilocularis arginine glutamic acid dipeptide (RE) repeats 0.0019 0.0015 0.0023
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Brugia malayi N-terminal motif family protein 0.0571 0.3468 0.5558
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Echinococcus granulosus protein tyrosine phosphatase n9 0.0024 0.0046 0.007
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0136 0.0748 0.1199
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.009 0.0459 0.0709
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0024 0.0046 0.007
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0011 0.0018
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0039 0.0141 0.0209
Onchocerca volvulus 0.0024 0.0046 0.0132
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0084 0.042 0.0648
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0099 0.0515 0.0515
Trichomonas vaginalis DNA helicase recq1, putative 0.0099 0.0516 0.0805
Brugia malayi SET domain containing protein 0.0023 0.0042 0.0068
Trichomonas vaginalis Heterochromatin protein, putative 0.0099 0.0515 0.0803
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0024 0.0046 0.007
Schistosoma mansoni hypothetical protein 0.0039 0.0141 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0295 0.1745 0.2784
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0019 0.0017 0.0017
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0358 0.2136 0.3412
Toxoplasma gondii small ubiquitin family modifier, putative 0.0278 0.1632 0.2609
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0126 0.019
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.005 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0515 0.0803
Echinococcus granulosus lysine specific demethylase 5A 0.0332 0.1972 0.3046
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Entamoeba histolytica deoxycytidyl transferase, putative 0.0288 0.17 0.2698
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0019 0.0015 0.0015
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0024 0.0046 0.007
Schistosoma mansoni smad1 5 8 and 0.0026 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0515 0.0803
Onchocerca volvulus 0.0022 0.0032 0.0092
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.089 0.5461 0.8752
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0153 0.0245
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0024 0.0046 0.0046
Brugia malayi Protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0288 0.17 0.2725
Loa Loa (eye worm) hypothetical protein 0.0338 0.2013 0.3226
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0024 0.0046 0.007
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0024 0.0046 0.0046
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0024 0.0046 0.0046
Trypanosoma cruzi hypothetical protein 0.002 0.0023 0.0018
Echinococcus multilocularis Protein lozenge 0.0054 0.0233 0.0359
Plasmodium falciparum ataxin-2 like protein, putative 0.0082 0.0412 0.0643
Echinococcus multilocularis Smad4 0.0026 0.0062 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.0638 0.1006
Schistosoma mansoni protein phosphatase 2C 0.0088 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.0163 0.0917 0.1469
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0027 0.0069 0.0074
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0034 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.0638 0.1006
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0151 0.0223
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0041 0.0153 0.0227
Entamoeba histolytica hypothetical protein 0.0099 0.0515 0.0792
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0028 0.0073 0.0118
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.1014 0.6238 1
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0173 0.0499
Trichomonas vaginalis DNA helicase recq, putative 0.0053 0.0228 0.0342
Trypanosoma cruzi hypothetical protein 0.002 0.0023 0.0018
Schistosoma mansoni regulator of G protein signaling 0.0028 0.0073 0.0073
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Trichomonas vaginalis phosphofructokinase, putative 0.0099 0.0516 0.0804
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0023 0.0000014746
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0101 0.0527 0.0813
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0083 0.0418 0.0418
Brugia malayi hypothetical protein 0.0028 0.0073 0.0118
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0043
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0037
Trichomonas vaginalis DNA polymerase eta, putative 0.0317 0.1881 0.2998
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Plasmodium vivax heterochromatin protein 1, putative 0.0099 0.0515 0.0809
Leishmania major DNA polymerase kappa, putative 0.0089 0.0457 0.0715
Trichomonas vaginalis conserved hypothetical protein 0.024 0.1395 0.2217
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0099 0.0515 0.0792
Trypanosoma brucei DNA polymerase kappa, putative 0.0317 0.1881 0.3002
Echinococcus multilocularis metastasis associated protein 1 (mta1) 0.0019 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.1014 0.6238 1
Onchocerca volvulus 0.0024 0.0046 0.0132
Loa Loa (eye worm) heterochromatin protein 1 0.0604 0.3671 0.5884
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0294 0.0471
Onchocerca volvulus 4.1 G protein, putative homolog 0.0024 0.0046 0.0132
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0051
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0099 0.0515 0.0515
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0024 0.0046 0.0073
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.005 0.0048
Echinococcus multilocularis 6 phosphofructokinase 0.0366 0.2185 0.3375
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0028 0.0073 0.0118
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.006 0.0063
Plasmodium falciparum ataxin-2 like protein, putative 0.0082 0.0412 0.0643
Entamoeba histolytica acetyltransferase, GNAT family 0.0085 0.0428 0.0651
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0089 0.0455 0.0712
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0095 0.049 0.0763
Loa Loa (eye worm) hypothetical protein 0.0029 0.0078 0.0124
Brugia malayi regulator of G-protein signaling egl-10 0.0028 0.0073 0.0118
Onchocerca volvulus 0.0043 0.0164 0.0472
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.1753 0.2793
Loa Loa (eye worm) jmjC domain-containing protein 0.0088 0.0448 0.0718
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0008
Onchocerca volvulus 0.0024 0.0046 0.0132
Schistosoma mansoni cpg binding protein 0.0144 0.0796 0.0796
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0019 0.0015 0.0015
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.1014 0.6238 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.011
Echinococcus granulosus Small ubiquitin modifier 2 0.0278 0.1632 0.2521
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0011 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0317 0.1881 0.3002
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0166 0.0256
Toxoplasma gondii kringle domain-containing protein 0.0039 0.0141 0.0217
Toxoplasma gondii exonuclease III APE 0.006 0.0274 0.043
Trypanosoma brucei metacaspase MCA2 0.0083 0.0418 0.0653
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0515 0.0803
Brugia malayi mbt repeat family protein 0.0264 0.1547 0.248
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0253 0.1476 0.2366
Trypanosoma brucei DNA polymerase kappa, putative 0.0317 0.1881 0.3002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0111 0.0171
Echinococcus granulosus endonuclease exonuclease phosphatase 0.1052 0.6473 1
Plasmodium vivax small ubiquitin-related modifier, putative 0.0278 0.1632 0.2603
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0011 0.0017
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0024 0.0046 0.0046
Trichomonas vaginalis pten, drome, putative 0.0024 0.0046 0.0049
Loa Loa (eye worm) RNA binding protein 0.0063 0.0294 0.0471
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0099 0.0515 0.0816
Brugia malayi Bromodomain containing protein 0.0045 0.0177 0.0284
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0141 0.0209
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0024 0.0046 0.0046
Loa Loa (eye worm) TK/ROR protein kinase 0.0039 0.0141 0.0227
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.005 0.0048
Trypanosoma brucei unspecified product 0.0199 0.1141 0.1813
Plasmodium falciparum cysteine repeat modular protein 1 0.0039 0.0141 0.0209
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0338 0.2013 0.5804
Trypanosoma brucei DNA polymerase kappa, putative 0.0317 0.1881 0.3002
Trypanosoma cruzi small ubiquitin protein, putative 0.0278 0.1632 0.2603
Onchocerca volvulus 0.0099 0.0515 0.1486
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.089 0.5461 0.8753
Toxoplasma gondii phosphoglycerate kinase PGKII 0.1014 0.6238 1
Echinococcus granulosus phd:f box containing protein 0.0088 0.0448 0.0691
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0062 0.0099
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0024 0.0046 0.007
Entamoeba histolytica phosphofructokinase, putative 0.0366 0.2185 0.3478
Trypanosoma brucei unspecified product 0.031 0.1836 0.293
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0366 0.2185 0.349
Entamoeba histolytica ubiquitin like protein 0.0278 0.1632 0.259
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0206 0.1185 0.1885
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Brugia malayi AMP-binding enzyme family protein 0.0023 0.004 0.0065
Plasmodium vivax SET domain protein, putative 0.0037 0.013 0.0191
Echinococcus multilocularis geminin 0.0532 0.3221 0.4976
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0023 0.0000014746
Brugia malayi 6-phosphofructokinase 0.0366 0.2185 0.3502
Brugia malayi Heterochromatin protein 1 0.0604 0.3671 0.5884
Echinococcus multilocularis dna polymerase eta 0.0509 0.3078 0.4754
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0151 0.0218
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0024 0.0046 0.007
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.0362 0.0362
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0069 0.0086
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0099 0.0515 0.0803
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Brugia malayi Disco-interacting protein 2 homolog 0.0163 0.0917 0.1469
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0099 0.0516 0.0785
Echinococcus granulosus ubiquitin 0.0171 0.0969 0.1496
Echinococcus multilocularis caspase 0.0083 0.0418 0.0645
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0073 0.0112
Brugia malayi ImpB/MucB/SamB family protein 0.0509 0.3078 0.4934
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0136 0.0748 0.1155
Echinococcus granulosus Chromo domain 0.0099 0.0515 0.0795
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0274 0.0369
Onchocerca volvulus 0.0428 0.2573 0.7419
Loa Loa (eye worm) CXXC zinc finger family protein 0.0142 0.0784 0.1257
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0099 0.0516 0.0793
Plasmodium vivax ataxin-2 like protein, putative 0.0082 0.0412 0.0643
Echinococcus multilocularis Chromo domain 0.0099 0.0515 0.0795
Brugia malayi jmjC domain containing protein 0.0893 0.548 0.8785
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.02 0.0321
Leishmania major DNA damage repair protein, putative 0.0089 0.0457 0.0715
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0362 0.0563
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0374
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.002 0.0023 0.0012
Loa Loa (eye worm) TK/ALK protein kinase 0.0018 0.0008 0.0012
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0037 0.0128 0.0197
Trypanosoma brucei DNA polymerase eta, putative 0.0509 0.3078 0.4924
Echinococcus granulosus DNA methyltransferase 2, putative 0.0084 0.042 0.0648
Giardia lamblia PHD finger protein 15 0.0273 0.1602 0.2513
Plasmodium vivax 6-phosphofructokinase, putative 0.0099 0.0516 0.0809
Trichomonas vaginalis conserved hypothetical protein 0.0278 0.1632 0.2599
Loa Loa (eye worm) hypothetical protein 0.0099 0.0515 0.0826
Leishmania major phosphoglycerate kinase B, cytosolic 0.1014 0.6238 1
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0166 0.0256
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Toxoplasma gondii ImpB/MucB/SamB family protein 0.031 0.1835 0.2934
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0274 0.0397
Brugia malayi Bloom's syndrome protein homolog 0.0099 0.0516 0.0828
Brugia malayi hypothetical protein 0.0024 0.0046 0.0073
Brugia malayi MH1 domain containing protein 0.0026 0.0062 0.0099
Schistosoma mansoni DNA helicase recq5 0.0041 0.0153 0.0153
Schistosoma mansoni hypothetical protein 0.0273 0.1602 0.1602
Echinococcus granulosus jumonji domain containing 1A 0.0088 0.0448 0.0691
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0024 0.0046 0.0046
Schistosoma mansoni Smad4 0.0026 0.0062 0.0062
Treponema pallidum hypothetical protein 0.089 0.5461 0.8749
Echinococcus multilocularis apoptotic protease activating factor 1 0.0031 0.0091 0.0139
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0083 0.0418 0.066
Mycobacterium ulcerans DNA polymerase IV 0.0317 0.1881 0.2991
Trypanosoma brucei PAB1-binding protein , putative 0.0082 0.0412 0.0643
Mycobacterium ulcerans 6-phosphofructokinase 0.0366 0.2185 0.3481
Echinococcus multilocularis JmjC domain containing protein 4 0.0088 0.0448 0.0691
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0011 0.0017
Schistosoma mansoni cpg binding protein 0.0142 0.0784 0.0784
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0024 0.0046 0.0046
Trypanosoma cruzi metacaspase 5, putative 0.0083 0.0418 0.0653
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0136 0.0748 0.0748
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0099 0.0515 0.0803
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0028 0.0028
Trichomonas vaginalis phosphofructokinase, putative 0.0099 0.0516 0.0804
Trypanosoma cruzi polo-like protein kinase, putative 0.0297 0.1753 0.2797
Onchocerca volvulus 0.0024 0.0046 0.0132
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0273 0.1602 0.1602
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.002 0.0023 0.0012
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.03 0.1775 0.2742
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0024 0.0046 0.0037
Leishmania major hypothetical protein, conserved 0.0088 0.0448 0.0701
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0024 0.0046 0.0037
Loa Loa (eye worm) hypothetical protein 0.0083 0.0418 0.067
Brugia malayi Pre-SET motif family protein 0.0253 0.1476 0.2366
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0294 0.0471
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0274 0.0422
Schistosoma mansoni hypothetical protein 0.0034 0.0111 0.0111
Echinococcus granulosus histone acetyltransferase KAT2B 0.0306 0.1808 0.2793
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0024 0.0046 0.007
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0151 0.0151
Echinococcus multilocularis phd:f box containing protein 0.0088 0.0448 0.0691
Toxoplasma gondii DNA methyltransferase 2, putative 0.0084 0.042 0.0664
Mycobacterium ulcerans DNA polymerase IV 0.0317 0.1881 0.2991
Giardia lamblia Sgs1 DNA helicase, putative 0.0041 0.0153 0.0173
Brugia malayi chromobox protein homolog 3 0.0338 0.2013 0.3226
Schistosoma mansoni chromobox protein 0.0604 0.3671 0.3671
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0418 0.0647
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0084 0.042 0.0656
Brugia malayi Valyl-tRNA synthetase 0.0099 0.0515 0.0826
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0366 0.2185 0.3495
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0028 0.0073 0.0112
Loa Loa (eye worm) hypothetical protein 0.0088 0.0448 0.0718
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0073 0.0112
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.1753 0.2793
Brugia malayi polk-prov protein 0.0118 0.0638 0.1022
Onchocerca volvulus 0.0024 0.0046 0.0132
Brugia malayi MH1 domain containing protein 0.0026 0.0062 0.0099
Onchocerca volvulus 0.0024 0.0046 0.0132
Entamoeba histolytica phosphofructokinase, putative 0.0366 0.2185 0.3478
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0099 0.0515 0.0803
Plasmodium falciparum phosphoglycerate kinase 0.1014 0.6238 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.006 0.0063
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0062 0.0094
Echinococcus multilocularis segment polarity protein dishevelled 0.0028 0.0073 0.0112
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0027 0.0069 0.0105
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0062 0.0094
Loa Loa (eye worm) hypothetical protein 0.0034 0.0111 0.0178
Echinococcus granulosus histone acetyltransferase KAT2B 0.0095 0.049 0.0756
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0295 0.1745 0.2788
Brugia malayi RasGEF domain containing protein 0.002 0.0023 0.0037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0317 0.1881 0.3002
Echinococcus multilocularis Small ubiquitin modifier 2 0.0278 0.1632 0.2521
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0233 0.0233
Echinococcus granulosus son of sevenless 1 0.002 0.0023 0.0034
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.005 0.0048
Brugia malayi Smad1 0.0026 0.0062 0.0099
Loa Loa (eye worm) hypothetical protein 0.0041 0.0153 0.0245
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0455 0.0719
Onchocerca volvulus 0.0024 0.0046 0.0132
Brugia malayi hypothetical protein 0.0053 0.023 0.0368
Toxoplasma gondii PHD-finger domain-containing protein 0.0273 0.1602 0.2561
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0297 0.1753 0.2797
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0151 0.0169
Echinococcus granulosus bloom syndrome protein 0.0099 0.0516 0.0797
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0024 0.0046 0.0055
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Loa Loa (eye worm) DIX domain-containing protein 0.0028 0.0073 0.0118
Echinococcus granulosus JmjC domain containing protein 4 0.0088 0.0448 0.0691
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0418 0.0647
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0274 0.0422
Loa Loa (eye worm) hypothetical protein 0.0082 0.0412 0.066
Echinococcus granulosus tar DNA binding protein 0.0063 0.0294 0.0453
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.02 0.0308
Leishmania major DNA polymerase kappa, putative 0.0295 0.1745 0.2784
Echinococcus multilocularis 0.0024 0.0046 0.007
Echinococcus multilocularis caspase 8 0.0083 0.0418 0.0645
Echinococcus granulosus phosphoglycerate kinase 1 0.1014 0.6238 0.9637
Trypanosoma cruzi DNA damage repair protein, putative 0.0089 0.0457 0.0715
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0092 0.047 0.047
Brugia malayi Protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Echinococcus granulosus lysine specific demethylase 6a 0.0088 0.0448 0.0691
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0118
Schistosoma mansoni hypothetical protein 0.0099 0.0515 0.0515
Onchocerca volvulus 0.0018 0.0008 0.0022
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0073 0.0112
Brugia malayi 6-phosphofructokinase 0.0366 0.2185 0.3502
Trichomonas vaginalis phosphofructokinase, putative 0.0099 0.0516 0.0804
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0359 0.0575
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0294 0.0294
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0099 0.0516 0.0817
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0306 0.0472
Onchocerca volvulus Cell death protein 3 homolog 0.0114 0.0611 0.1762
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0151 0.0232
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Loa Loa (eye worm) hypothetical protein 0.0088 0.0448 0.0718
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0084 0.042 0.0656
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0151 0.0223
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0028 0.0026
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.002 0.0023 0.0034
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0089 0.0455 0.0712
Trichomonas vaginalis chromobox protein, putative 0.0099 0.0515 0.0803
Trichomonas vaginalis conserved hypothetical protein 0.024 0.1395 0.2217
Echinococcus multilocularis caspase 2 0.0114 0.0611 0.0943
Brugia malayi hypothetical protein 0.0171 0.0969 0.1553
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0042 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0115 0.0176
Echinococcus granulosus CTD small phosphatase protein like 0.0027 0.0069 0.0105
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0001 0.0001
Trichomonas vaginalis dullard protein, putative 0.0027 0.0069 0.0086
Echinococcus multilocularis dna polymerase kappa 0.0317 0.1881 0.2905
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0024 0.0046 0.0046
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.0418 0.0647
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0274 0.0405
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0024 0.0046 0.007
Schistosoma mansoni hypothetical protein 0.0037 0.0128 0.0128
Trypanosoma cruzi metacaspase 5, putative 0.0083 0.0418 0.0653
Trypanosoma brucei metacaspase 0.0083 0.0418 0.0653
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.004 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.0457 0.0715
Brugia malayi hypothetical protein 0.0024 0.0046 0.0073
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0099 0.0516 0.0759
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0099 0.0515 0.0816
Echinococcus multilocularis chromobox protein 2 0.0099 0.0515 0.0795
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.006 0.0063
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0027 0.0069 0.0105
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.006 0.0086
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0099 0.0515 0.0515
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0011 0.0017
Brugia malayi jmjC domain containing protein 0.0332 0.1972 0.3162
Schistosoma mansoni sex comb on midleg homolog 0.0264 0.1547 0.1547
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0372 0.2225 0.3555
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.0457 0.0715
Loa Loa (eye worm) phosphofructokinase 0.0366 0.2185 0.3502
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0066 0.0311 0.0489
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5107 0.789
Trypanosoma brucei DNA polymerase kappa, putative 0.0317 0.1881 0.3002
Echinococcus granulosus apoptotic protease activating factor 1 0.0031 0.0091 0.0139
Echinococcus granulosus ras GTP exchange factor 0.002 0.0023 0.0034
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0088 0.0448 0.0701
Echinococcus multilocularis lysine specific demethylase 5A 0.033 0.1961 0.3028
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0037 0.0129 0.0198
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.006 0.0063
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0088 0.0448 0.0708
Trichomonas vaginalis DNA helicase recq, putative 0.0099 0.0516 0.0805
Loa Loa (eye worm) hypothetical protein 0.0099 0.0515 0.0826
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0087 0.0441 0.069
Trypanosoma brucei unspecified product 0.0199 0.1141 0.1813
Echinococcus granulosus peregrin 0.0293 0.1729 0.2671
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.009 0.0459 0.0709
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Loa Loa (eye worm) acetyltransferase 0.0317 0.1878 0.301
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.0418 0.0647
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0024 0.0046 0.007
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Loa Loa (eye worm) hypothetical protein 0.0307 0.1815 0.291
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0573 0.0918
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0288 0.17 0.2625
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.058 0.3522 0.5635
Echinococcus granulosus jumonji domain containing protein 0.0379 0.227 0.3506
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0274 0.0417
Onchocerca volvulus 0.0024 0.0046 0.0132
Schistosoma mansoni protein tyrosine phosphatase 0.0024 0.0046 0.0046
Onchocerca volvulus 0.0099 0.0515 0.1486
Echinococcus multilocularis Chromobox protein 3 0.0099 0.0515 0.0795
Trypanosoma cruzi DNA polymerase kappa, putative 0.0317 0.1881 0.3002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0099 0.0515 0.0803
Loa Loa (eye worm) jmjC domain-containing protein 0.0088 0.0448 0.0718
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0023 0.0000014746
Brugia malayi N-terminal motif family protein 0.002 0.0023 0.0037
Plasmodium falciparum metacaspase 1 0.0083 0.0418 0.0653
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.0428 0.2573 0.4124
Trypanosoma brucei phosphoglycerate kinase, putative 0.0372 0.2225 0.3555
Echinococcus multilocularis zinc finger protein 0.0027 0.0064 0.0098
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0024 0.0046 0.0073
Trichomonas vaginalis chromobox protein, putative 0.0099 0.0515 0.0803
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0024 0.0046 0.0055
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0023 0.0024
Entamoeba histolytica serine/threonine protein kinase, putative 0.0297 0.1753 0.2784
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0151 0.0223
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.005 0.0081
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.006 0.0084
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0062 0.0094
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0111 0.0178
Echinococcus granulosus MAM 0.0018 0.0008 0.0011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0099 0.0515 0.0803
Schistosoma mansoni terminal deoxycytidyl transferase 0.0288 0.17 0.17
Echinococcus multilocularis cpg binding protein 0.0144 0.0796 0.1228
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.1753 0.2793
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Brugia malayi Muscle positioning protein 4 0.0022 0.0032 0.0051
Onchocerca volvulus 0.0024 0.0046 0.0132
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0024 0.0046 0.007
Echinococcus multilocularis metastasis associated protein MTA1 0.0019 0.0015 0.0023
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Plasmodium falciparum histone acetyltransferase GCN5 0.0085 0.0428 0.0668
Toxoplasma gondii phosphofructokinase PFKII 0.0099 0.0516 0.0817
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0024 0.0046 0.007
Echinococcus multilocularis chromobox protein 1 0.0604 0.3671 0.567
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0274 0.044
Brugia malayi Phosphoglycerate kinase 0.0372 0.2225 0.3567
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0288 0.17 0.17
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.002 0.0023 0.0023
Mycobacterium ulcerans polyketide synthase 0.0024 0.005 0.0048
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.002 0.0023 0.0066
Brugia malayi RasGEF domain containing protein 0.002 0.0023 0.0037
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0163 0.0917 0.0917
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1683 0.2599
Schistosoma mansoni hypothetical protein 0.0034 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Onchocerca volvulus 0.0023 0.004 0.0117
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0024 0.0046 0.007
Plasmodium vivax hypothetical protein, conserved 0.0273 0.1602 0.2554
Schistosoma mansoni 6-phosphofructokinase 0.0366 0.2185 0.2185
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0099 0.0515 0.0792
Brugia malayi Ubiquitin-like protein SMT3 0.0278 0.1632 0.2617
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0024
Echinococcus granulosus Pleckstrin G protein interacting region 0.0028 0.0073 0.0112
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Schistosoma mansoni smad 0.0026 0.0062 0.0062
Schistosoma mansoni caspase-7 (C14 family) 0.0114 0.0611 0.0611
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Giardia lamblia Kinase, PLK 0.0297 0.1753 0.2757
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0893 0.548 0.8466
Schistosoma mansoni hypothetical protein 0.002 0.0022 0.0022
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0088 0.0448 0.0701
Onchocerca volvulus 0.0024 0.0046 0.0132
Schistosoma mansoni sex comb on midleg homolog 0.0264 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0041 0.0154 0.0247
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0024 0.0046 0.007
Echinococcus granulosus caspase 0.0083 0.0418 0.0645
Brugia malayi RasGEF domain containing protein 0.002 0.0023 0.0037
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0024 0.0046 0.007
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0089 0.0457 0.0723
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0089 0.0455 0.0719
Onchocerca volvulus 0.0024 0.0046 0.0132
Entamoeba histolytica phosphofructokinase, putative 0.0366 0.2185 0.3478
Onchocerca volvulus 0.0024 0.0046 0.0132
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Plasmodium vivax 6-phosphofructokinase, putative 0.0099 0.0516 0.0809
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0362 0.0563
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.0362 0.0546
Leishmania major hypothetical protein, conserved 0.0027 0.0069 0.0092
Loa Loa (eye worm) transcription factor SMAD2 0.0385 0.2307 0.3698
Brugia malayi Bromodomain containing protein 0.008 0.0399 0.0639
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.02 0.0308
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0024 0.0046 0.007
Schistosoma mansoni myelin transcription factor 1 myt1 0.03 0.1775 0.1775
Loa Loa (eye worm) hypothetical protein 0.0118 0.0638 0.1022
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0153 0.0245
Trichomonas vaginalis bromodomain-containing protein, putative 0.0095 0.049 0.0763
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.1753 0.2793
Onchocerca volvulus 0.0287 0.1693 0.4883
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Loa Loa (eye worm) hypothetical protein 0.0571 0.3468 0.5558
Schistosoma mansoni blooms syndrome DNA helicase 0.0078 0.0386 0.0386
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.0418 0.0647
Trypanosoma brucei DNA polymerase kappa, putative 0.0317 0.1881 0.3002
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.002 0.0023 0.0034
Onchocerca volvulus 0.0024 0.0046 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.0816 0.1287
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0118
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Trichomonas vaginalis ras GTP exchange factor, putative 0.002 0.0023 0.0012
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.005 0.0048
Schistosoma mansoni ap endonuclease 0.006 0.0274 0.0274
Trypanosoma cruzi polo-like protein kinase, putative 0.0297 0.1753 0.2797
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0053 0.0228 0.0348
Toxoplasma gondii PHD-finger domain-containing protein 0.0273 0.1602 0.2561
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0083 0.0418 0.066
Trichomonas vaginalis phosphoglycerate kinase, putative 0.1014 0.6238 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0264 0.1547 0.1547
Echinococcus granulosus chromobox protein 1 0.0604 0.3671 0.567
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.03 0.1775 0.2742
Leishmania major ATP-dependent phosphofructokinase 0.0366 0.2185 0.349
Loa Loa (eye worm) jmjC domain-containing protein 0.0563 0.3417 0.5478
Trypanosoma brucei phosphoglycerate kinase 0.0372 0.2225 0.3555
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.002 0.0023 0.0034
Brugia malayi hypothetical protein 0.0286 0.1683 0.2697
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0024 0.0046 0.007
Brugia malayi CXXC zinc finger family protein 0.0142 0.0784 0.1257
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.089 0.5461 0.8752
Loa Loa (eye worm) hypothetical protein 0.0099 0.0515 0.0826
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0083 0.0418 0.067
Trypanosoma cruzi phosphoglycerate kinase, putative 0.1014 0.6238 1
Trypanosoma brucei hypothetical protein, conserved 0.0089 0.0457 0.0715
Schistosoma mansoni hypothetical protein 0.0532 0.3221 0.3221
Trypanosoma cruzi metacaspase, putative 0.0083 0.0418 0.0653
Loa Loa (eye worm) hypothetical protein 0.0286 0.1683 0.2697
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0024 0.0046 0.0046
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0024 0.0046 0.007
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0317 0.1878 0.29
Trypanosoma brucei metacaspase MCA3 0.0083 0.0418 0.0653
Trypanosoma brucei DNA polymerase IV, putative 0.0317 0.1881 0.3002
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0151 0.0232
Schistosoma mansoni dishevelled 0.0028 0.0073 0.0073
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0274 0.044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.02 0.02
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0099 0.0515 0.0809
Brugia malayi Protein kinase domain containing protein 0.0018 0.0008 0.0012
Schistosoma mansoni DNA polymerase eta 0.0509 0.3078 0.3078
Loa Loa (eye worm) hypothetical protein 0.0273 0.1602 0.2568
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0136 0.0748 0.1155
Loa Loa (eye worm) hypothetical protein 0.0047 0.0192 0.0307
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.002 0.0023 0.0023
Echinococcus multilocularis jumonji domain containing protein 0.0379 0.227 0.3506
Toxoplasma gondii hypothetical protein 0.0028 0.0073 0.0107
Onchocerca volvulus 0.002 0.0023 0.0066
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0418 0.0653
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0083 0.0418 0.0647
Schistosoma mansoni zinc finger protein 0.0027 0.0064 0.0064
Leishmania major DNA polymerase eta, putative 0.031 0.1835 0.2928
Schistosoma mansoni phd/f-box containing protein 0.0088 0.0448 0.0448
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.0362 0.0563
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.089 0.5461 0.875
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0969 0.1532
Echinococcus multilocularis polycomb protein SCMH1 0.0264 0.1547 0.2389
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0069 0.0092
Trypanosoma brucei DNA damage repair protein, putative 0.0089 0.0457 0.0715
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0084 0.042 0.0656
Plasmodium falciparum JmjC domain-containing protein, putative 0.0088 0.0448 0.0701
Brugia malayi hypothetical protein 0.0018 0.0008 0.0012
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0101 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0024
Onchocerca volvulus 0.0264 0.1547 0.4461
Trypanosoma brucei DNA polymerase kappa, putative 0.0317 0.1881 0.3002
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0046 0.0062
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.005 0.0069
Brugia malayi CHD4 protein 0.0101 0.0527 0.0844
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Brugia malayi AF-10 protein 0.0089 0.0455 0.0729
Chlamydia trachomatis phosphoglycerate kinase 0.1014 0.6238 1
Plasmodium vivax phosphoglycerate kinase, putative 0.1014 0.6238 1
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0028 0.0073 0.0211
Trypanosoma brucei small ubiquitin-related modifier 0.0278 0.1632 0.2603
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.2013 0.321
Schistosoma mansoni hypothetical protein 0.0027 0.0067 0.0067
Loa Loa (eye worm) RecQ helicase 0.0099 0.0516 0.0828
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0062 0.0062
Entamoeba histolytica recQ family helicase, putative 0.0053 0.0228 0.033
Schistosoma mansoni DNA polymerase IV / kappa 0.0089 0.0457 0.0457
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0372 0.2225 0.3555
Schistosoma mansoni ras GTP exchange factor 0.002 0.0023 0.0023
Echinococcus granulosus dna polymerase eta 0.0509 0.3078 0.4754
Echinococcus granulosus GPCR family 2 0.0034 0.0111 0.0171
Brugia malayi hypothetical protein 0.0024 0.0046 0.0073
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0069 0.0086
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0893 0.548 0.8466
Echinococcus granulosus polycomb protein SCMH1 0.0264 0.1547 0.2389
Loa Loa (eye worm) protein tyrosine phosphatase 0.0024 0.0046 0.0073
Brugia malayi jmjC domain containing protein 0.0088 0.0448 0.0718
Schistosoma mansoni lozenge 0.0054 0.0233 0.0233
Loa Loa (eye worm) jmjC domain-containing protein 0.0088 0.0448 0.0718
Schistosoma mansoni hypothetical protein 0.0031 0.0091 0.0091
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0274 0.0408
Echinococcus multilocularis chromobox protein 1 0.0604 0.3671 0.567
Loa Loa (eye worm) hypothetical protein 0.0049 0.0203 0.0326
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0062 0.0099
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0027 0.0069 0.01
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.005 0.0069
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0024 0.0046 0.007
Echinococcus granulosus smad 0.0026 0.0062 0.0094
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0046 0.0073
Trypanosoma cruzi DNA polymerase eta, putative 0.031 0.1835 0.2928
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0024 0.0046 0.0046
Loa Loa (eye worm) PHD-finger family protein 0.0273 0.1602 0.2568
Onchocerca volvulus 0.0024 0.0046 0.0132
Loa Loa (eye worm) hypothetical protein 0.0099 0.0515 0.0826
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0088 0.0448 0.0708
Onchocerca volvulus 0.0024 0.0046 0.0132
Echinococcus multilocularis phosphoglycerate kinase 1 0.1014 0.6238 0.9637
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0037 0.0129 0.0198
Loa Loa (eye worm) Smad1 0.0026 0.0062 0.0099
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0084 0.042 0.0639
Onchocerca volvulus 0.0024 0.0046 0.0132
Giardia lamblia DINP protein human, muc B family 0.0295 0.1745 0.2744
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0034 0.0051
Echinococcus granulosus caspase 8 0.0083 0.0418 0.0645
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Echinococcus multilocularis peregrin 0.0293 0.1729 0.2671
Trichomonas vaginalis phosphofructokinase, putative 0.0366 0.2185 0.3486
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0515 0.0803
Brugia malayi ImpB/MucB/SamB family protein 0.0288 0.17 0.2725
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0097 0.0502 0.0795
Loa Loa (eye worm) hypothetical protein 0.0509 0.3078 0.4934
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0099 0.0515 0.0795
Trypanosoma brucei DNA polymerase kappa, putative 0.0317 0.1881 0.3002
Schistosoma mansoni jumonji domain containing protein 0.0709 0.4333 0.4333
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0099 0.0516 0.0809
Loa Loa (eye worm) helicase 0.0099 0.0515 0.0826
Schistosoma mansoni 6-phosphofructokinase 0.0366 0.2185 0.2185
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0099 0.0515 0.0816
Plasmodium vivax metacaspase 1, putative 0.0083 0.0418 0.0653
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0048 0.0078
Schistosoma mansoni caspase-7 (C14 family) 0.0083 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0264 0.1547 0.248
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0372 0.2225 0.3555
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0046 0.0073
Mycobacterium tuberculosis Conserved hypothetical protein 0.0288 0.17 0.2716
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0024 0.0046 0.007
Loa Loa (eye worm) hypothetical protein 0.0099 0.0515 0.0826
Trypanosoma cruzi PAB1-binding protein , putative 0.0082 0.0412 0.0643
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0111 0.0171
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0027 0.0069 0.0037
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0024 0.0046 0.0037
Mycobacterium ulcerans thioesterase 0.002 0.0025 0.0007
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0041 0.0153 0.0236
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0115 0.0176
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0294 0.0453
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0099 0.0515 0.0803
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0515 0.0803
Onchocerca volvulus 0.0136 0.0748 0.2157
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0099 0.0515 0.0803
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0024 0.0046 0.0055
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0023 0.0000014746
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0151 0.0232
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0126 0.017
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0099 0.0516 0.0804
Loa Loa (eye worm) hypothetical protein 0.0099 0.0515 0.0826
Toxoplasma gondii phosphoglycerate kinase PGKI 0.1014 0.6238 1
Echinococcus multilocularis son of sevenless 1 0.002 0.0023 0.0034
Loa Loa (eye worm) MH2 domain-containing protein 0.0385 0.2307 0.3698
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0028 0.0073 0.0073
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.002 0.0023 0.0023
Trichomonas vaginalis phosphofructokinase, putative 0.0099 0.0516 0.0804
Echinococcus multilocularis hypothetical protein 0.0024 0.0046 0.007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.1753 0.1753
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Echinococcus multilocularis ras GTP exchange factor 0.002 0.0023 0.0034
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0073
Brugia malayi DIX domain containing protein 0.0028 0.0073 0.0118
Onchocerca volvulus 0.0024 0.0046 0.0132
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0364 0.2173 0.6267
Echinococcus granulosus zinc finger protein 0.0027 0.0064 0.0098

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.04114 um PUBCHEM_BIOASSAY: Thrombin 1536 HTS Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 1046 (Thrombin 1536 HTS; hits were confirmed in this assay)] ChEMBL. No reference
IC50 (functional) 1.047786667 uM PUBCHEM_BIOASSAY: Factor XIIa 1536 HTS Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID800] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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