Detailed information for compound 44948

Basic information

Technical information
  • TDR Targets ID: 44948
  • Name: 5-(dithiolan-3-yl)pentanoic acid
  • MW: 206.326 | Formula: C8H14O2S2
  • H donors: 1 H acceptors: 2 LogP: 1.68 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCCCC1SSCC1
  • InChi: 1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
  • InChiKey: AGBQKNBQESQNJD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(3-dithiolanyl)pentanoic acid
  • 5-(1,2-dithiolan-3-yl)pentanoic acid
  • 5-(dithiolan-3-yl)valeric acid
  • Thioctic Acid
  • berlition
  • 62-46-4
  • 1077-28-7
  • (.+-.)-.alpha.-Lipoic acid
  • (.+-.)-Lipoic acid
  • (.+-.)-Thioctic acid
  • 6,8-Dithiooctanoic acid
  • (RS)-Lipoic acid
  • .alpha.-Liponic acid
  • 1,2-Dithiolane-3-pentanoic acid, (.+-.)-
  • 1,2-Dithiolane-3-valeric acid, (.+-.)-
  • DL-.alpha.-Lipoic acid
  • T1395_SIGMA
  • dl-Lipoic acid
  • MLS000069736
  • Spectrum2_001605
  • KBio3_002335
  • (RS)-.alpha.-Lipoic acid
  • AIDS-030563
  • KBio2_004666
  • 1,2-dithiolane-3-pentanoic acid
  • 5-(1,2-dithiolan-3-yl)-pentanoate
  • LIPOIC-ACID
  • alpha-liponic acid
  • lipoic acid
  • Spectrum5_001298
  • KBio2_007234
  • (+-)-1,2-Dithiolane-3-pentanoic acid
  • 1,2-DITHIOLANE-3-VALERIC ACID, (+-)-
  • 1,2-Dithiolane-3-pentanoic acid, (+-)- (9CI)
  • BRN 0081853
  • DL-1,2-Dithiolan-3-valeriansaeure [German]
  • DL-1,2-Dithiolane 3-valeric acid
  • DL-1,2-Dithiolane-3-valeric acid
  • DL-6,8-Thioctic acid
  • DL-6-Thioctic acid
  • DL-alpha-Lipoic acid
  • EINECS 214-071-2
  • NSC 628502
  • Biletan
  • Rac-lipoate
  • Thioctic acid dl-form
  • dl-Thioctic acid
  • C00725
  • alpha-Lipoic acid
  • 62320_FLUKA
  • NCGC00090872-05
  • Thioctsaeure
  • BSPBio_002835
  • NSC90788
  • SBB003484
  • IDI1_000912
  • KBio2_002098
  • ()-1,2-Dithiolane-3-pentanoic acid
  • ()-alpha-Lipoic acid
  • Lip(S2)
  • T5625_SIAL
  • KBioGR_000853
  • Spectrum4_000217
  • SMR000058198
  • NINDS_000912
  • Thioctansaeure
  • Spectrum3_001188
  • SPECTRUM1503941
  • NCI60_042014
  • DivK1c_000912
  • CHEBI:16494
  • D00086
  • Thioctic acid (JAN)
  • Thiotomin (TN)
  • alpha-Liponsaeure
  • KBio1_000912
  • KBioSS_002098
  • NCGC00090872-02
  • (+/-)-1,2-Dithiolane-3-pentanoic acid
  • NCGC00090872-03
  • AIDS030563
  • NSC628502
  • NSC 90788
  • 1,2-Dithiolane-3-valeric acid
  • SPBio_001609
  • NCGC00090872-01
  • Thiooctic acid
  • Spectrum_001618

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens ubiquitin-like modifier activating enzyme 2 Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Homo sapiens retinoid X receptor, alpha Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Homo sapiens SUMO1 activating enzyme subunit 1 No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Mus musculus eukaryotic translation initiation factor 4E Starlite/ChEMBL No references
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Human immunodeficiency virus type 1 Tat protein Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase Get druggable targets OG5_131193 All targets in OG5_131193
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans mRNA cap-binding protein eIF4E, translation initiation Get druggable targets OG5_127278 All targets in OG5_127278
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis eukaryotic translation initiation factor 4E Get druggable targets OG5_127278 All targets in OG5_127278
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania mexicana eukaryotic translation initiation factor eIF-4E, putative Get druggable targets OG5_127278 All targets in OG5_127278
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Neospora caninum hypothetical protein Get druggable targets OG5_127278 All targets in OG5_127278
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi SUMO-activating enzyme subunit 1, putative Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium falciparum SUMO-activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative Get druggable targets OG5_127278 All targets in OG5_127278
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense ubiquitin-activating enzyme e1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Giardia lamblia Ubiquitin-activating enzyme E1 1 Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni retinoic acid receptor RXR Get druggable targets OG5_130073 All targets in OG5_130073
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative Get druggable targets OG5_127278 All targets in OG5_127278
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative Get druggable targets OG5_127278 All targets in OG5_127278
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 Get druggable targets OG5_127278 All targets in OG5_127278
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium parvum translation initiation factor if-4E Get druggable targets OG5_127278 All targets in OG5_127278
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense eukaryotic translation initiation factor 4e, putative Get druggable targets OG5_127278 All targets in OG5_127278
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative Get druggable targets OG5_127838 All targets in OG5_127838
Theileria parva hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Plasmodium vivax ubiquitin activating enzyme, putative Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium yoelii SUMO-1 activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ThiF family protein Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative Get druggable targets OG5_127278 All targets in OG5_127278
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus SUMO activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to Uba1 (Ub-activating enzyme) Get druggable targets OG5_127838 All targets in OG5_127838
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum eukaryotic translation initiation factor eIF-4E, putative Get druggable targets OG5_127278 All targets in OG5_127278
Leishmania donovani Eukaryotic translation initiation factor 4E-2 Get druggable targets OG5_127278 All targets in OG5_127278
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis initiation factor e4 Get druggable targets OG5_127278 All targets in OG5_127278
Neospora caninum AFR138Wp, related Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus retinoic acid receptor rxr beta a Get druggable targets OG5_130073 All targets in OG5_130073
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase Get druggable targets OG5_131193 All targets in OG5_131193
Echinococcus multilocularis SUMO activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Candida albicans similar to S. cerevisiae AOS1 (YPR180W) which mediates conjugation of ubiquitin-like Smt3p (sumoylation) to target proteins Get druggable targets OG5_128859 All targets in OG5_128859
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Schistosoma japonicum ko:K10684 ubiquitin-like 1-activating enzyme E1 A, putative Get druggable targets OG5_128859 All targets in OG5_128859
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum SUMO-1 activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Theileria parva hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni sumo-1-activating enzyme E1a Get druggable targets OG5_128859 All targets in OG5_128859
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei SUMO-activating enzyme subunit 1, putative Get druggable targets OG5_128859 All targets in OG5_128859
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense Eukaryotic translation initiation factor 4E-1 Get druggable targets OG5_127278 All targets in OG5_127278
Plasmodium berghei SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus eukaryotic translation initiation factor 4E Get druggable targets OG5_127278 All targets in OG5_127278
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans similar to Uba1 (Ub-activating enzyme) Get druggable targets OG5_127838 All targets in OG5_127838
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi translation initiation factor 4E Get druggable targets OG5_127278 All targets in OG5_127278
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major eukaryotic translation initiation factor-like protein Get druggable targets OG5_127278 All targets in OG5_127278
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis conserved hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis SUMO activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major eukaryotic translation initiation factor eIF-4E, putative Get druggable targets OG5_127278 All targets in OG5_127278
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 Get druggable targets OG5_127278 All targets in OG5_127278
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative Get druggable targets OG5_127278 All targets in OG5_127278
Cryptosporidium hominis SUMO-1 activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium yoelii related to ubiquitin-activating enzyme homolog UBA2-related Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K03259 translation initiation factor eIF-4E, putative Get druggable targets OG5_127278 All targets in OG5_127278
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense ubiquitin-activating enzyme E1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni sumo-1-activating enzyme E1a Get druggable targets OG5_128859 All targets in OG5_128859
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva translation initiation factor E4, putative Get druggable targets OG5_127278 All targets in OG5_127278
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative Get druggable targets OG5_130073 All targets in OG5_130073
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum eukaryotic translation initiation factor-like protein Get druggable targets OG5_127278 All targets in OG5_127278
Echinococcus granulosus sumo-activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni eukaryotic translation initiation factor 4e Get druggable targets OG5_127278 All targets in OG5_127278
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva ubiquitin-protein ligase, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) translation initiation factor 4E Get druggable targets OG5_127278 All targets in OG5_127278
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis eukaryotic translation initiation factor eIF-4E, putative Get druggable targets OG5_127278 All targets in OG5_127278
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU Get druggable targets OG5_131193 All targets in OG5_131193
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU Get druggable targets OG5_131193 All targets in OG5_131193
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani Eukaryotic translation initiation factor 4E-1 Get druggable targets OG5_127278 All targets in OG5_127278
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 Get druggable targets OG5_127278 All targets in OG5_127278
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium vivax SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma cruzi ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ubiquitin-activating enzyme E1b Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K10685 ubiquitin-like 1-activating enzyme E1 B, putative Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae AOS1 (YPR180W) which mediates conjugation of ubiquitin-like Smt3p (sumoylation) to target proteins Get druggable targets OG5_128859 All targets in OG5_128859
Toxoplasma gondii ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania mexicana eukaryotic translation initiation factor-like protein Get druggable targets OG5_127278 All targets in OG5_127278
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii eukaryotic initiation factor-4E, putative Get druggable targets OG5_127278 All targets in OG5_127278
Leishmania donovani ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha Get druggable targets OG5_130073 All targets in OG5_130073
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative Get druggable targets OG5_127278 All targets in OG5_127278
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei ubiquitin-activating enzyme E1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium falciparum SUMO-activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major eukaryotic translation initiation factor-like Get druggable targets OG5_127278 All targets in OG5_127278
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum eukaryotic translation initiation factor 4E eukaryotic translation initiation factor 4E 217 aa 188 aa 25.5 %
Echinococcus multilocularis squamous cell carcinoma antigen Human immunodeficiency virus type 1 Tat protein   86 aa 79 aa 30.4 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Brugia malayi ecdysteroid receptor retinoid X receptor, alpha 435 aa 352 aa 23.9 %
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0589 0.9523
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0218 0.0702
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.5641
Echinococcus granulosus zinc finger protein 0.0028 0.0043 0.0075
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0091 0.0176
Echinococcus granulosus neuropeptide s receptor 0.0048 0.016 0.0311
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0308 0.0661
Schistosoma mansoni hypothetical protein 0.0025 0.0025 0.0039
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0058 0.0222 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0349 0.4619
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Echinococcus granulosus g protein coupled receptor 0.0048 0.016 0.0311
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0088 0.0629
Mycobacterium tuberculosis Conserved hypothetical protein 0.0125 0.0618 0.1532
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0088 0.029
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0311
Loa Loa (eye worm) serotonin transporter b 0.047 0.265 0.5084
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0151 0.0145
Schistosoma mansoni myosin xvIII 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.5641
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0896 0.1988
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.016 0.0311
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0073 0.0132
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.016 0.0311
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0647 0.1605
Echinococcus multilocularis geminin 0.0865 0.4979 0.4976
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0181 0.0374
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0048 0.016 0.0155
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Plasmodium vivax amine transporter, putative 0.008 0.0349 0.8015
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0265 0.0522
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0096 0.019
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus multilocularis Protein lozenge 0.0067 0.0274 0.0269
Loa Loa (eye worm) beta-lactamase 0.0036 0.0091 0.0163
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.016 0.0298
Echinococcus multilocularis neuropeptide receptor 0.0048 0.016 0.0155
Trichomonas vaginalis DNA helicase recq1, putative 0.005 0.0172 0.0291
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.016 0.0298
Echinococcus multilocularis neuropeptide s receptor 0.0048 0.016 0.0155
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.047 0.265 0.5317
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Brugia malayi mbt repeat family protein 0.0058 0.0218 0.0408
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0335 0.0329
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) glutaminase 0.0317 0.1747 0.3348
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Echinococcus granulosus FTZ F1 alpha 0.0046 0.0148 0.0287
Brugia malayi ecdysteroid receptor 0.0046 0.0148 0.0274
Brugia malayi MH2 domain containing protein 0.0375 0.2091 0.401
Echinococcus multilocularis serotonin receptor 0.0299 0.1641 0.1637
Loa Loa (eye worm) RNA binding protein 0.0281 0.1534 0.2939
Loa Loa (eye worm) glutaminase 2 0.0317 0.1747 0.3348
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0046 0.0148 0.0287
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0029 0.0047
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Echinococcus granulosus biogenic amine 5HT receptor 0.0299 0.1641 0.3289
Trypanosoma brucei unspecified product 0.0065 0.0261 0.0555
Schistosoma mansoni peroxidasin 0.0032 0.0066 0.012
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.008 0.0349 0.0343
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0042 0.0124 0.0245
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0048 0.016 0.0311
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0058 0.0222 0.4671
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0038 0.0104 0.1583
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0054 0.0199 0.3215
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.0147
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0067 0.0134
Schistosoma mansoni ap endonuclease 0.0037 0.0096 0.0181
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1011 0.2542
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0684 0.3914 1
Loa Loa (eye worm) norepinephrine transporter 0.047 0.265 0.5084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0732 0.1825
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0148 0.0274
Echinococcus granulosus muscleblind protein 0.0149 0.0759 0.1514
Schistosoma mansoni bromodomain containing protein 0.0081 0.0354 0.0701
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0049 0.0166 0.037
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0046 0.0148 0.0274
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0349 0.0752
Echinococcus granulosus peroxidasin 0.0032 0.0066 0.012
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0647 0.1605
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.008 0.0349 0.7759
Loa Loa (eye worm) steroid hormone receptor 0.0046 0.0148 0.0274
Brugia malayi phosphofructokinase 0.0131 0.0653 0.1244
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0349 0.069
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.0199 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0046 0.0148 0.0274
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0091 0.1223
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0269 0.4349
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0903 0.5207 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0035 0.0082 0.0147
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0091 0.0176
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0349 0.0752
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0349 0.0752
Schistosoma mansoni intermediate filament proteins 0.0033 0.007 0.013
Brugia malayi ThiF family protein 0.0038 0.0104 0.019
Schistosoma mansoni lamin 0.0033 0.007 0.013
Schistosoma mansoni sodium/chloride dependent transporter 0.047 0.265 0.5317
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0046 0.0148 0.0274
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.016 0.0298
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0048 0.016 0.0155
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0653 0.1301
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0096 0.0181
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0046 0.0148 0.0287
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0732 0.1825
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0015 0.0018
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0046 0.0148 0.0143
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0653 0.1438
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0091 0.017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus granulosus somatostatin receptor 0.0048 0.016 0.0311
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0647 0.1605
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0093 0.0424 0.1034
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni biogenic amine receptor 0.0048 0.016 0.0311
Onchocerca volvulus 0.0058 0.0218 0.0702
Brugia malayi Bromodomain containing protein 0.0051 0.0176 0.0328
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0096 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0269 0.0529
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0218 0.0427
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0091 0.017
Loa Loa (eye worm) RecQ helicase 0.005 0.0172 0.0319
Loa Loa (eye worm) intermediate filament protein 0.0033 0.007 0.0124
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0896 0.1988
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni amine GPCR 0.0448 0.252 0.5055
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0349 0.069
Loa Loa (eye worm) hypothetical protein 0.0149 0.0759 0.1448
Brugia malayi larval opioid receptor 0.0048 0.016 0.0298
Brugia malayi RNA recognition motif domain containing protein 0.0281 0.1534 0.2939
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0112 0.1809
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0265 0.026
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.016 0.0298
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.016 0.0311
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0091 0.0011
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0091 0.0193
Loa Loa (eye worm) phosphofructokinase 0.0131 0.0653 0.1244
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0038 0.0104 0.0201
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus Smad4 0.0026 0.0029 0.0047
Echinococcus granulosus 7tm_1 domain containing protein 0.0048 0.016 0.0311
Schistosoma mansoni histamine h1 receptor 0.0048 0.016 0.0311
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0035 0.0082 0.0154
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0046 0.0148 0.0287
Trichomonas vaginalis DNA polymerase eta, putative 0.0073 0.0308 0.0764
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus multilocularis smad 0.0026 0.0029 0.0023
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0058 0.0222 0.0415
Onchocerca volvulus 0.0048 0.016 0.0511
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0112 0.0204
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0046 0.0148 0.0287
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0091 0.0171
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Brugia malayi beta-lactamase family protein 0.0036 0.0091 0.0163
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.016 0.0155
Brugia malayi Cytochrome P450 family protein 0.0034 0.0077 0.0137
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0281 0.1534 0.2939
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0058 0.0222 0.0434
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.016 0.0298
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0042 0.0124 0.0245
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0265 0.026
Brugia malayi neuropeptide F receptor 0.0048 0.016 0.0298
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0042 0.0124 0.0238
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0091 0.0011
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.016 0.0298
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.016 0.0311
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0091 0.0171
Brugia malayi photoreceptor-specific nuclear receptor 0.0046 0.0148 0.0274
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Schistosoma mansoni biogenic amine receptor 0.0048 0.016 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0265 0.0499
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.016 0.0311
Echinococcus granulosus allatostatin A receptor 0.0048 0.016 0.0311
Brugia malayi PHD-finger family protein 0.0034 0.0081 0.0145
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0042 0.0124 0.0238
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0011
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0157 0.8895
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0255 0.05
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0096 0.0207
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0589 0.1457
Toxoplasma gondii hypothetical protein 0.008 0.0349 0.5641
Brugia malayi latrophilin 2 splice variant baaae 0.0618 0.3521 0.6758
Echinococcus granulosus hypothetical protein 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0093 0.0424 0.0805
Echinococcus multilocularis g protein coupled receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Onchocerca volvulus Peroxidase homolog 0.0032 0.0066 0.0198
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0038 0.0104 0.1583
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0046 0.0148 0.0274
Brugia malayi G-protein coupled receptor 0.0048 0.016 0.0298
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0096 0.1626
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0096 0.0322
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0903 0.5207 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0096 0.1554
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0038 0.0104 0.0099
Trypanosoma brucei unspecified product 0.0028 0.0044 0.0065
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0057 0.0213 0.0507
Echinococcus multilocularis thyroid hormone receptor alpha 0.0198 0.1045 0.104
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Brugia malayi Smad1 0.0026 0.0029 0.0045
Onchocerca volvulus 0.0048 0.016 0.0511
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.016 0.0298
Treponema pallidum hypothetical protein 0.0027 0.0039 0.0108
Echinococcus multilocularis g protein coupled receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Loa Loa (eye worm) ThiF family protein 0.0038 0.0104 0.019
Toxoplasma gondii endonuclease IV APN 0.0093 0.0424 0.6861
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0653 0.1301
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0015 0.0018
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0048 0.016 0.0155
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Onchocerca volvulus 0.0048 0.016 0.0511
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.016 0.0311
Mycobacterium tuberculosis Probable reductase 0.013 0.0647 0.1605
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.016 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0046 0.0148 0.0274
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.016 0.0311
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.0583 0.0578
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.016 0.0311
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) transcription factor SMAD2 0.0375 0.2091 0.401
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0287 0.0697
Onchocerca volvulus 0.0048 0.016 0.0511
Schistosoma mansoni hypothetical protein 0.0152 0.0775 0.1547
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0653 0.1244
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0349 0.069
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0287 0.0613
Echinococcus multilocularis G-protein coupled receptor, putative 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0299 0.1641 0.3145
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Leishmania major DNA polymerase eta, putative 0.0043 0.0134 0.0269
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0141 0.0708 0.0703
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.016 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0046 0.0148 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0142 0.0287
Echinococcus granulosus g protein coupled receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) latrophilin receptor protein 2 0.0286 0.1564 0.2997
Echinococcus multilocularis g-protein coupled receptor 0.0048 0.016 0.0155
Mycobacterium ulcerans epimerase 0.0024 0.0022 0.0017
Brugia malayi Bloom's syndrome protein homolog 0.005 0.0172 0.0319
Trypanosoma brucei C-8 sterol isomerase, putative 0.0775 0.4447 1
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus 7TM GPCR rhodopsin 0.0048 0.016 0.0311
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.047 0.265 0.5084
Echinococcus granulosus carboxylesterase 5A 0.0082 0.0361 0.0715
Mycobacterium ulcerans hypothetical protein 0.0125 0.0618 0.1547
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.033 0.1828 0.1823
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.203 0.4545
Loa Loa (eye worm) hypothetical protein 0.0286 0.1564 0.2997
Brugia malayi Cytochrome P450 family protein 0.0023 0.0015 0.0018
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0653 0.1244
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0088 0.1142
Toxoplasma gondii ABC1 family protein 0.0036 0.0091 0.1465
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0091 0.0193
Loa Loa (eye worm) hypothetical protein 0.0082 0.0361 0.0684
Schistosoma mansoni glutaminase 0.0317 0.1747 0.3501
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0311
Brugia malayi Cytochrome P450 family protein 0.0023 0.0015 0.0018
Brugia malayi hypothetical protein 0.0077 0.0335 0.0633
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0039 0.0033
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.0653 0.162
Echinococcus granulosus neuropeptide FF receptor 2 0.0048 0.016 0.0311
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.033 0.1828 0.3503
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.016 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0535 0.3033 0.5821
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0349 0.069
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.5641
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0589 0.1294
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0073 0.0132
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0042 0.0124 0.2005
Loa Loa (eye worm) hypothetical protein 0.0066 0.0265 0.0499
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni thyroid hormone receptor 0.0198 0.1045 0.209
Schistosoma mansoni zinc finger protein 0.0028 0.0043 0.0075
Schistosoma mansoni Smad4 0.0026 0.0029 0.0047
Brugia malayi Dopamine receptor 0.0048 0.016 0.0298
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0035 0.0082 0.0077
Onchocerca volvulus Chorion peroxidase homolog 0.0032 0.0066 0.0198
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.016 0.0298
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0111 0.0535 0.1332
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0127
Echinococcus granulosus acetylcholinesterase 0.0082 0.0361 0.0715
Echinococcus multilocularis neuropeptide FF receptor 2 0.0048 0.016 0.0155
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0053 0.0236
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0647 0.1605
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0048 0.016 0.0155
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0119 0.0228
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0286 0.1564 0.3134
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Onchocerca volvulus Peroxidasin homolog 0.0032 0.0066 0.0198
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0029 0.0047
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0021 0.0031
Echinococcus granulosus acetylcholinesterase 0.0082 0.0361 0.0715
Onchocerca volvulus 0.008 0.0349 0.1133
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0031
Loa Loa (eye worm) hypothetical protein 0.0087 0.039 0.074
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.1828 0.3663
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0349 0.069
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0049 0.0794
Echinococcus multilocularis lamin dm0 0.0033 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Onchocerca volvulus 0.0048 0.016 0.0511
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0589 0.1471
Schistosoma mansoni peroxidasin 0.0032 0.0066 0.012
Echinococcus granulosus serotonin transporter 0.047 0.265 0.5317
Brugia malayi hypothetical protein 0.0036 0.0089 0.0161
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0044 0.0713
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0042 0.0124 0.0245
Plasmodium falciparum amino acid transporter, putative 0.008 0.0349 0.8015
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0218 0.0427
Brugia malayi Inositol-1 0.0037 0.0096 0.0174
Toxoplasma gondii hypothetical protein 0.008 0.0349 0.5641
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0234 0.1261 0.2524
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0088 0.1142
Brugia malayi MH1 domain containing protein 0.0026 0.0029 0.0045
Brugia malayi Blistered cuticle protein 3 0.0032 0.0066 0.0115
Echinococcus granulosus smad 0.0026 0.0029 0.0047
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0589 0.1471
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus granulosus histone lysine methyltransferase setb 0.0087 0.039 0.0774
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0054 0.0199 0.3215
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Plasmodium vivax SET domain protein, putative 0.0066 0.0269 0.5914
Onchocerca volvulus 0.0032 0.0066 0.0198
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.016 0.0311
Schistosoma mansoni adenoreceptor 0.0048 0.016 0.0311
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0021 0.0031
Toxoplasma gondii thioredoxin reductase 0.0057 0.0215 0.3479
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Echinococcus multilocularis bloom syndrome protein 0.005 0.0172 0.0166
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.0653 0.1301
Onchocerca volvulus 0.0048 0.016 0.0511
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0589 0.1471
Brugia malayi hypothetical protein 0.0024 0.0021 0.0029
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0096 0.1361
Entamoeba histolytica recQ family helicase, putative 0.0038 0.0101 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0011
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0096 0.009
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0057 0.0213 0.0507
Leishmania major hypothetical protein, conserved 0.0036 0.0091 0.017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0286 0.1564 0.1559
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.016 0.0298
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0011
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0038 0.0104 0.0198
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.033 0.1828 0.3663
Echinococcus granulosus GPCR family 2 0.0286 0.1564 0.3134
Brugia malayi Carboxylesterase family protein 0.0082 0.0361 0.0684
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.0308 0.0752
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0166 0.034
Mycobacterium ulcerans beta-lactamase 0.0036 0.0091 0.0193
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.016 0.0298
Brugia malayi MH2 domain containing protein 0.0026 0.0029 0.0045
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0035 0.0082 0.0077
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0021 0.0029
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0589 0.1173
Plasmodium vivax glutathione reductase, putative 0.0057 0.0215 0.4499
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0024 0.0022 0.0054
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0045 0.0142 0.0263
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0286 0.1564 0.3134
Loa Loa (eye worm) hypothetical protein 0.0775 0.4447 0.854
Schistosoma mansoni smad1 5 8 and 0.0026 0.0029 0.0047
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0112 0.0204
Trichomonas vaginalis aldehyde oxidase, putative 0.0168 0.0869 0.2704
Onchocerca volvulus Protein ultraspiracle homolog 0.0046 0.0148 0.0471
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Schistosoma mansoni blooms syndrome DNA helicase 0.0032 0.0068 0.0124
Brugia malayi glutathione reductase 0.0057 0.0215 0.0403
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0148 0.0287
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0147
Schistosoma mansoni hypothetical protein 0.004 0.0112 0.0214
Echinococcus granulosus bloom syndrome protein 0.005 0.0172 0.0333
Brugia malayi Carboxylesterase family protein 0.0082 0.0361 0.0684
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0088 0.1415
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus granulosus alpha 1A adrenergic receptor 0.0048 0.016 0.0311
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0091 0.0176
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0286 0.1564 0.1559
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0148 0.0287
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0181 0.0374
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0218 0.0213
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0096 0.009
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0157 0.296
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0054 0.0199 0.0385
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0057 0.0213 0.049
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Brugia malayi hypothetical protein 0.0032 0.0066 0.0115
Brugia malayi Pre-SET motif family protein 0.0066 0.0269 0.0506
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0234 0.1261 0.1256
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0053 0.019 0.0371
Echinococcus granulosus fmrfamide receptor 0.0048 0.016 0.0311
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.008 0.0349 0.069
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.007 0.0124
Mycobacterium ulcerans endonuclease IV 0.0093 0.0424 0.1049
Echinococcus granulosus serotonin receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0029 0.0045
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0039 0.0067
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.016 0.0311
Schistosoma mansoni inositol monophosphatase 0.0037 0.0096 0.0182
Loa Loa (eye worm) hypothetical protein 0.0396 0.2213 0.4245
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.0653 0.1438
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0287 0.0541
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0215 0.0451
Mycobacterium ulcerans hypothetical protein 0.0192 0.1011 0.2555
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.005 0.0172 0.0402
Echinococcus multilocularis serotonin receptor 0.0299 0.1641 0.1637
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0049 0.0166 0.034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.039 0.0774
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.039 0.0774
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.0653 0.0647
Schistosoma mansoni ap endonuclease 0.0037 0.0096 0.0181
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0077 0.0137
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0096 0.0029
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0119 0.0555
Brugia malayi Sodium:neurotransmitter symporter family protein 0.047 0.265 0.5084
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0046 0.0148 0.0287
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.016 0.0311
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0039 0.0067
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0349 0.0689
Trypanosoma brucei unspecified product 0.0028 0.0044 0.0065
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0181 0.0374
Onchocerca volvulus 0.0036 0.0091 0.028
Brugia malayi beta-lactamase family protein 0.0036 0.0091 0.0163
Loa Loa (eye worm) hypothetical protein 0.0299 0.1641 0.3145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0046 0.0148 0.0274
Treponema pallidum sodium- and chloride- dependent transporter 0.047 0.265 1
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0112 0.0106
Brugia malayi TAR-binding protein 0.0281 0.1534 0.2939
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0021 0.0015
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0181 0.0374
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0096 0.0173
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0112 0.0204
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.033 0.1828 0.3503
Schistosoma mansoni inositol monophosphatase 0.0037 0.0096 0.0182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus multilocularis somatostatin receptor 0.0048 0.016 0.0155
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.007 0.0124
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.016 0.0311
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0349 0.069
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.03 0.0643
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0096 0.003
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0349 0.0689
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0653 0.1438
Leishmania major hypothetical protein, conserved 0.0028 0.0044 0.0065
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.03 0.0567
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0361 0.0356
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0775 0.1547
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0684 0.3914 1
Loa Loa (eye worm) translation initiation factor 4E 0.0042 0.0124 0.0227
Brugia malayi Dopamine receptor protein 2 0.0048 0.016 0.0298
Onchocerca volvulus 0.0535 0.3033 1
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0032 0.0067 0.0117
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.008 0.0349 0.069
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.016 0.0298
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0119 0.0228
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.016 0.0311
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.008 0.0349 0.0343
Loa Loa (eye worm) solute carrier family 6 member 4 0.047 0.265 0.5084
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.016 0.0311
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.0653 0.1635
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0119 0.0113
Brugia malayi Serotonin receptor 0.0048 0.016 0.0298
Schistosoma mansoni opsin-like receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0096 0.0173
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0178 0.0928 0.1854
Echinococcus granulosus intermediate filament protein 0.0033 0.007 0.013
Loa Loa (eye worm) carboxylesterase 0.0082 0.0361 0.0684
Brugia malayi follicle stimulating hormone receptor 0.0048 0.016 0.0298
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0079 0.0345 0.0847
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Brugia malayi acetyltransferase, GNAT family protein 0.0178 0.0928 0.1773
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0134 0.0129
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0589 0.1173
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0035 0.0082 0.0154
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Brugia malayi hypothetical protein 0.0535 0.3033 0.5821
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0096 0.003
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0349 0.0343
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0042 0.0124 0.0245
Brugia malayi nuclear receptor RXR 0.0024 0.0021 0.0029
Echinococcus granulosus lamin dm0 0.0033 0.007 0.013
Loa Loa (eye worm) MBCTL1 0.0066 0.0265 0.0499
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0349 0.069
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0148 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0148 0.0274
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0287 0.0281
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0088 0.1142
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0134 0.2174
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0046 0.0148 0.0274
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.133
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni lozenge 0.0067 0.0274 0.054
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0125 0.0618 0.1547
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0424 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0589 0.1173
Echinococcus granulosus ecdysone induced protein 78C 0.0046 0.0148 0.0287
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0155
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.0653 0.162
Trichomonas vaginalis glutaminase, putative 0.0317 0.1747 0.5742
Leishmania major trypanothione reductase 0.0057 0.0215 0.0451
Toxoplasma gondii exonuclease III APE 0.0037 0.0096 0.155
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0168 0.0869 0.2704
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.016 0.0155
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0048 0.016 0.0155
Echinococcus granulosus geminin 0.0865 0.4979 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0349 0.0659
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0101 0.0193
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0732 0.1825
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0287 0.0697
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0148 0.0143
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0653 1
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0215 0.0403
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.016 0.0155
Echinococcus multilocularis allatostatin A receptor 0.0048 0.016 0.0155
Echinococcus multilocularis dna polymerase eta 0.0072 0.03 0.0295
Schistosoma mansoni hypothetical protein 0.0865 0.4979 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0155
Onchocerca volvulus Peroxidasin homolog 0.0032 0.0066 0.0198
Mycobacterium ulcerans hypothetical protein 0.0027 0.0039 0.0062
Toxoplasma gondii ThiF family protein 0.0038 0.0104 0.1686
Echinococcus granulosus uncharacterized sodium dependent transporter 0.008 0.0349 0.069
Plasmodium vivax hypothetical protein, conserved 0.008 0.0349 0.8015
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0218 0.0408
Brugia malayi Melatonin receptor type 1A 0.0048 0.016 0.0298
Plasmodium falciparum glutathione reductase 0.0057 0.0215 0.4499
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.203 0.4545
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0091 0.0171
Onchocerca volvulus 0.0033 0.007 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0148 0.0274
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.008 0.0349 0.069
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0046 0.0148 0.0287
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.0199 0.4069
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0046 0.0148 0.0274
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.1234 0.3115
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0101 0.0193
Onchocerca volvulus 0.047 0.265 0.8734
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0093 0.0424 0.0805
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.016 0.0311
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0021 0.0031
Loa Loa (eye worm) blistered cuticle protein 3 0.0032 0.0066 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0361 0.0356
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0096 0.0182
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0775 0.077
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.133
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0015 0.0018
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus sex peptide receptor 0.0048 0.016 0.0311
Onchocerca volvulus 0.0032 0.0066 0.0198
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0044 0.0065
Onchocerca volvulus 0.0048 0.016 0.0511
Loa Loa (eye worm) hypothetical protein 0.0058 0.0218 0.0408
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0349 0.0659
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0349 0.0752
Onchocerca volvulus 0.0048 0.016 0.0511
Onchocerca volvulus 0.0036 0.0091 0.028
Brugia malayi beta-lactamase 0.0036 0.0091 0.0163
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0265 0.0522
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0653 1
Trichomonas vaginalis esterase, putative 0.0036 0.0091 0.0011
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Onchocerca volvulus 0.0048 0.016 0.0511
Mycobacterium tuberculosis Conserved hypothetical protein 0.0125 0.0618 0.1532
Brugia malayi G-protein coupled receptor 0.0048 0.016 0.0298
Onchocerca volvulus 0.0048 0.016 0.0511
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.008 0.0349 0.069
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Calcitonin receptor-like protein seb-1 0.0903 0.5207 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0329 0.0323
Echinococcus granulosus g-protein coupled receptor 0.0048 0.016 0.0311
Schistosoma mansoni smad1 5 8 and 0.0026 0.0029 0.0047
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0048 0.016 0.0298
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0096 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0269 0.0529
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Brugia malayi intermediate filament protein 0.0033 0.007 0.0124
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0096 0.0151
Loa Loa (eye worm) hypothetical protein 0.0149 0.0759 0.1448
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0048 0.016 0.0511
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0096 0.0182
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0067 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0046 0.0148 0.0274
Schistosoma mansoni hypothetical protein 0.0618 0.3521 0.7068
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Leishmania major DNA polymerase eta, putative 0.0072 0.03 0.0643
Brugia malayi Serotonin receptor 0.0048 0.016 0.0298
Brugia malayi hypothetical protein 0.008 0.0349 0.066
Schistosoma mansoni coup transcription factor 0.0046 0.0148 0.0287
Loa Loa (eye worm) hypothetical protein 0.0072 0.03 0.0567
Mycobacterium ulcerans hypothetical protein 0.0125 0.0618 0.1547
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0091 0.0171
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0048 0.016 0.0311
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0589 0.0584
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0046 0.0148 0.0143
Echinococcus granulosus dro:myosuppressin receptor 0.0048 0.016 0.0311
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0215 0.0496
Brugia malayi 6-phosphofructokinase 0.0131 0.0653 0.1244
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0215 0.4499
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0046 0.0148 0.0274
Mycobacterium ulcerans glutaminase 0.0317 0.1747 0.4442
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0148 0.0274
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0029 0.0045
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0218 0.0427
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0046 0.0152 0.0281
Echinococcus multilocularis dro:myosuppressin receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) inositol-1 0.0037 0.0096 0.0174
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.008 0.0349 0.0343
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0088 0.1415
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0775 0.4447 1
Echinococcus multilocularis carboxylesterase 5A 0.0082 0.0361 0.0356
Echinococcus multilocularis musashi 0.0033 0.007 0.0065
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0287 0.0681
Loa Loa (eye worm) hypothetical protein 0.0535 0.3033 0.5821
Onchocerca volvulus 0.0066 0.0269 0.087
Giardia lamblia DINP protein human, muc B family 0.0049 0.0166 1
Onchocerca volvulus 0.0036 0.0091 0.028
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0265 0.0522
Loa Loa (eye worm) runx1 0.0067 0.0274 0.0516
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.047 0.265 0.5084
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0112 0.1783
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0046 0.0148 0.0274
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0046 0.0148 0.0471
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0047 0.0153 0.2865
Echinococcus granulosus uncharacterized sodium dependent transporter 0.008 0.0349 0.069
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0087 0.039 0.0385
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0119 0.0218
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Trichomonas vaginalis DNA helicase recq, putative 0.005 0.0172 0.0291
Loa Loa (eye worm) hypothetical protein 0.004 0.0112 0.0204
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0024 0.0022 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0091 0.0176
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0148 0.0287
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0178 0.0928 0.0922
Brugia malayi Peroxidasin 0.0032 0.0066 0.0115
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.203 0.4545
Treponema pallidum quinoline 2-oxidoreductase 0.0027 0.0036 0.0093
Onchocerca volvulus 0.008 0.0349 0.1133
Loa Loa (eye worm) hypothetical protein 0.0053 0.0194 0.0362
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Onchocerca volvulus 0.0032 0.0066 0.0198
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0349 0.069
Brugia malayi hypothetical protein 0.0028 0.0044 0.0074
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.016 0.0298
Mycobacterium ulcerans hypothetical protein 0.0024 0.0022 0.0017
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0048 0.016 0.0155
Echinococcus granulosus dna polymerase kappa 0.0073 0.0308 0.0608
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0218 0.0427
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Trichomonas vaginalis bromodomain-containing protein, putative 0.0054 0.0199 0.0385
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.016 0.0298
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0259 0.0488
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0335 0.0662
Schistosoma mansoni sodium-dependent amino acid transporter 0.008 0.0349 0.069
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0119 0.0218
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0287 0.0566
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0046 0.0148 0.0287
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0025 0.0038
Echinococcus granulosus G protein coupled receptor 139 0.0048 0.016 0.0311
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0029 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0148 0.0274
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0046 0.0148 0.0143
Brugia malayi steroid hormone receptor 0.0046 0.0148 0.0274
Echinococcus multilocularis dna polymerase kappa 0.0073 0.0308 0.0303
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Onchocerca volvulus 0.0048 0.016 0.0511
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0093 0.0424 0.1034
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0038 0.0104 0.0201
Onchocerca volvulus 0.0033 0.007 0.0214
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0647 0.1605
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0096 0.1361
Onchocerca volvulus 0.0048 0.016 0.0511
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Onchocerca volvulus 0.0525 0.2978 0.9817
Echinococcus granulosus tar DNA binding protein 0.0281 0.1534 0.3073
Loa Loa (eye worm) MH2 domain-containing protein 0.0375 0.2091 0.401
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0247 0.0523
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0042 0.0124 0.0118
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.016 0.0155
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0079 0.0345 0.0847
Mycobacterium ulcerans hypothetical protein 0.0036 0.0091 0.0193
Brugia malayi GnHR receptor homolog 0.0048 0.016 0.0298
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0308 0.0661
Loa Loa (eye worm) acetyltransferase 0.0178 0.0928 0.1773
Brugia malayi Steroid receptor seven-up type 2 0.0046 0.0148 0.0274
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0134 0.0269
Toxoplasma gondii hypothetical protein 0.0059 0.0225 0.3643
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.016 0.0311
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0349 0.0343
Onchocerca volvulus Neuropeptide F receptor homolog 0.0048 0.016 0.0511
Brugia malayi translation initiation factor 4E 0.0042 0.0124 0.0227
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0029 0.0047
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.008 0.0349 0.066
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0286 0.1564 0.2997
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0096 0.0182
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0151 0.0291
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0091 0.017
Brugia malayi AKH receptor 0.0048 0.016 0.0298
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0046 0.0148 0.0287
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0215 0.021
Leishmania major ubiquitin-activating enzyme-like protein 0.0038 0.0104 0.0201
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.203 0.4545
Loa Loa (eye worm) acetylcholinesterase 1 0.0082 0.0361 0.0684
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0775 0.4447 0.854
Schistosoma mansoni thyroid hormone receptor 0.0198 0.1045 0.209
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Brugia malayi RE15519p 0.0048 0.016 0.0298
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0096 0.0207
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0119 0.0228
Echinococcus granulosus g protein coupled receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Trypanosoma brucei trypanothione reductase 0.0057 0.0215 0.0451
Echinococcus multilocularis muscleblind protein 0.0149 0.0759 0.0754
Leishmania major eukaryotic translation initiation factor-like 0.0042 0.0124 0.0245
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0684 0.3914 1
Brugia malayi hypothetical protein 0.0036 0.0089 0.0161
Echinococcus multilocularis tar DNA binding protein 0.0281 0.1534 0.1529
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0073 0.0308 0.0764
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0218 0.0213
Echinococcus granulosus orexin receptor type 2 0.0048 0.016 0.0311
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0349 0.069
Leishmania major C-8 sterol isomerase-like protein 0.0775 0.4447 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.016 0.0311
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0091 0.0176
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0091 0.0176
Echinococcus multilocularis fmrfamide receptor 0.0048 0.016 0.0155
Echinococcus multilocularis ecdysone induced protein 78C 0.0046 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.016 0.0311
Echinococcus granulosus neuropeptide receptor 0.0048 0.016 0.0311
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0653 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.033 0.1828 0.1823
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) TAR-binding protein 0.0281 0.1534 0.2939
Loa Loa (eye worm) hypothetical protein 0.0082 0.0361 0.0684
Echinococcus multilocularis neuropeptide receptor 0.0048 0.016 0.0155
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.0147
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.016 0.0311
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0287 0.0566
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.1828 0.3663
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0646
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0684 0.3914 1
Echinococcus granulosus lamin 0.0033 0.007 0.013
Brugia malayi 6-phosphofructokinase 0.0131 0.0653 0.1244
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Brugia malayi Latrophilin receptor protein 2 0.0286 0.1564 0.2997
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0046 0.0148 0.0274
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Onchocerca volvulus Peroxidase homolog 0.0032 0.0066 0.0198
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0124
Brugia malayi nuclear hormone receptor 0.0046 0.0148 0.0274
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0046 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Brugia malayi Pre-SET motif family protein 0.0462 0.2602 0.4991
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0048 0.016 0.0311
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0329 0.065
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0165 0.085 0.1699
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0349 0.069
Brugia malayi mbt repeat family protein 0.0058 0.0218 0.0408
Schistosoma mansoni biogenic amine (5HT) receptor 0.0299 0.1641 0.3289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0091 0.0163
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0038 0.0104 0.0198
Schistosoma mansoni opsin-like receptor 0.0048 0.016 0.0311
Brugia malayi nuclear receptor NHR-88 0.0046 0.0148 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.1828 0.3663
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus tachykinin peptides receptor 99D 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0029 0.0023
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0462 0.2602 0.4991
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0896 0.1988
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni opsin-like receptor 0.0048 0.016 0.0311
Brugia malayi MH1 domain containing protein 0.0026 0.0029 0.0045
Treponema pallidum licC protein (licC) 0.0125 0.0618 0.2302
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0046 0.0148 0.0287
Plasmodium vivax ubiquitin activating enzyme, putative 0.0058 0.0222 0.4671
Trichomonas vaginalis DNA helicase recq, putative 0.0038 0.0101 0.0046
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0035 0.0082 0.1003
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Brugia malayi Dopamine receptor protein 1 0.0048 0.016 0.0298
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0101 0.0193
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0647 0.1605
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0079 0.0345 0.0831
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0335 0.0662
Brugia malayi MH2 domain containing protein 0.0026 0.0029 0.0045
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0148 0.0143
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0732 0.1825
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.016 0.0311
Echinococcus multilocularis fmrfamide receptor 0.0048 0.016 0.0155
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0091 0.0085
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0215 0.0421
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.016 0.0298
Echinococcus granulosus peptide allatostatin:somatostatin 0.0048 0.016 0.0311
Echinococcus granulosus neuropeptide receptor 0.0048 0.016 0.0311
Schistosoma mansoni DNA helicase recq5 0.0035 0.0082 0.0154
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Chlamydia trachomatis endonuclease IV 0.0093 0.0424 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.0653 0.2431
Echinococcus multilocularis FTZ F1 alpha 0.0046 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi ORL1-like opioid receptor 0.0048 0.016 0.0298
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.016 0.0311
Brugia malayi neuropeptide F receptor 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0032 0.0067 0.0118
Echinococcus multilocularis lamin 0.0033 0.007 0.0065
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Onchocerca volvulus Bile acid receptor homolog 0.0046 0.0148 0.0471
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0882 0.1761
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0261 0.0555
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0044 0.0065
Schistosoma mansoni hypothetical protein 0.0077 0.0335 0.0662
Schistosoma mansoni biogenic amine receptor 0.0048 0.016 0.0311
Brugia malayi Bromodomain containing protein 0.0095 0.0438 0.0831
Echinococcus multilocularis orexin receptor type 2 0.0048 0.016 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0142 0.0287
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.0073 0.013
Brugia malayi hypothetical protein 0.0024 0.0021 0.0029
Schistosoma mansoni hypothetical protein 0.0358 0.1988 0.3985
Echinococcus multilocularis zinc finger protein 0.0028 0.0043 0.0037
Loa Loa (eye worm) Smad1 0.0026 0.0029 0.0045
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.016 0.0298
Trichomonas vaginalis set domain proteins, putative 0.0525 0.2978 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0074
Brugia malayi sulfakinin receptor protein 0.0048 0.016 0.0298
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Brugia malayi ThiF family protein 0.0058 0.0222 0.0415
Toxoplasma gondii hypothetical protein 0.0058 0.0222 0.3585
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0024 0.0022 0.0031
Echinococcus multilocularis G protein coupled receptor 139 0.0048 0.016 0.0155
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0134 0.0259
Brugia malayi polk-prov protein 0.0045 0.0142 0.0263
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0058 0.0222 0.0434
Echinococcus multilocularis sex peptide receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0903 0.5207 1
Onchocerca volvulus 0.0046 0.0148 0.0471
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0048 0.016 0.0311
Schistosoma mansoni DNA polymerase eta 0.0072 0.03 0.0592
Brugia malayi Thioredoxin reductase 0.0057 0.0215 0.0403
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0176
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0021 0.0029
Mycobacterium ulcerans lipase LipD 0.0036 0.0091 0.0193
Echinococcus multilocularis g protein coupled receptor 0.0048 0.016 0.0155
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0091 0.0176
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0029 0.0046
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0112 0.1783
Onchocerca volvulus 0.0048 0.016 0.0511
Onchocerca volvulus 0.008 0.0349 0.1133
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.016 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0096 0.0148
Echinococcus granulosus neuropeptide receptor A26 0.0048 0.016 0.0311
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0096 0.0001
Onchocerca volvulus Dual oxidase homolog 0.0032 0.0066 0.0198
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0759 0.0754
Loa Loa (eye worm) hypothetical protein 0.0085 0.0382 0.0724
Mycobacterium leprae Probable lipase LipE 0.0036 0.0091 0.0176
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Schistosoma mansoni steroid hormone receptor ad4bp 0.0046 0.0148 0.0287
Loa Loa (eye worm) hypothetical protein 0.0056 0.0207 0.0388
Brugia malayi Muscleblind-like protein 0.0149 0.0759 0.1448
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0088 0.1142
Schistosoma mansoni lipoxygenase 0.0084 0.0371 0.0734
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0091 0.0171
Echinococcus multilocularis neuropeptide receptor A26 0.0048 0.016 0.0155
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0091 0.0176
Schistosoma mansoni lamin 0.0033 0.007 0.013
Echinococcus multilocularis Smad4 0.0026 0.0029 0.0023
Loa Loa (eye worm) glutathione reductase 0.0057 0.0215 0.0403
Loa Loa (eye worm) hypothetical protein 0.047 0.265 0.5084
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0148 0.0274
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis peroxidasin 0.0032 0.0066 0.006
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0091 0.0163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.033 0.1828 0.3663
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0088 0.1415
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0424 1
Schistosoma mansoni retinoic acid receptor RXR 0.0165 0.085 0.1699
Plasmodium falciparum transporter, putative 0.008 0.0349 0.8015
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0044 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0046 0.0148 0.0274
Schistosoma mansoni smad 0.0026 0.0029 0.0047
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0218 0.0427
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.016 0.0311
Schistosoma mansoni smad1 5 8 and 0.0026 0.0029 0.0047
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0269 0.0263
Plasmodium falciparum thioredoxin reductase 0.0057 0.0215 0.4499
Schistosoma mansoni hypothetical protein 0.0865 0.4979 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.016 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0148 0.0274
Schistosoma mansoni RAR-like nuclear receptor 0.0046 0.0148 0.0287
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0096 0.0029
Leishmania major DNA polymerase kappa, putative 0.0049 0.0166 0.034
Brugia malayi G protein-coupled receptor 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0618 0.3521 0.6758
Schistosoma mansoni lipoxygenase 0.0119 0.0583 0.1161
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0168 0.0869 0.2704
Echinococcus multilocularis serotonin transporter 0.047 0.265 0.2646
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0349 0.0343
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0091 0.0171
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.0361 0.0715
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0157 0.1224
Echinococcus multilocularis GPCR, family 2 0.0286 0.1564 0.1559
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0176
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0119 0.0249
Schistosoma mansoni DNA helicase recq1 0.0035 0.0082 0.0154
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0048 0.016 0.0155
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.0308 0.0752
Leishmania major eukaryotic translation initiation factor-like protein 0.0042 0.0124 0.0245
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0125 0.0618 1
Brugia malayi putative neuropeptide receptor 0.0048 0.016 0.0298
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.0583 0.1161
Brugia malayi glutaminase DH11.1 0.0317 0.1747 0.3348
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.03 0.0643
Echinococcus granulosus dna polymerase eta 0.0072 0.03 0.0592
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0096 0.003
Brugia malayi RNA binding protein 0.0281 0.1534 0.2939
Onchocerca volvulus 0.0048 0.016 0.0511

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) < 5 % Inhibition of human AchE-induced amyloid beta aggregation at 100 uM ChEMBL. 18181565
Activity (ADMET) = 13.3 % Viability of rotifers against doxorubicin toxicity at 10 uM ChEMBL. 16640342
Activity (ADMET) = 14.1 % Viability of rotifers against hydrogen peroxide toxicity at 10 uM ChEMBL. 16640342
Activity (functional) = 58.5 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 50 uM ChEMBL. 15658850
Activity (functional) = 74.33 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 10 uM ChEMBL. 15658850
Activity (functional) = 79.5 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 5 uM ChEMBL. 15658850
Activity (functional) = 83 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 1 uM ChEMBL. 15658850
Activity (functional) = 86 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 0 uM ChEMBL. 15658850
Activity (functional) = 90.25 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 0.5 uM ChEMBL. 15658850
Activity (functional) = 91.25 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 0.1 uM ChEMBL. 15658850
Activity (functional) = -18.6 nM Hydroxyl radical scavenging activity by ABTS competition assay per 30 mins at 1 umol/mL ChEMBL. 16640342
Activity (functional) = 44.1 nM Radical reducing potency by ABTS cation radical reduction assay per 30 mins at 1 umol/mL ChEMBL. 16640342
EC50 (functional) = 121.6 uM Ability of the compound for prevention of GSH depletion was measured in mouse ChEMBL. 12031315
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.523 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.465 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.366 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 1 nM Inhibition of human AchE ChEMBL. 18181565
IC50 (binding) > 1000000 nM Inhibitory concentration against human recombinant acetylcholinesterase ChEMBL. 15658850
IC50 (binding) > 1000000 nM Inhibitory concentration against human recombinant butyrylcholinesterase ChEMBL. 15658850
IC50 (binding) 0 uM In vitro inhibition concentration of the compound was evaluated on the effect of conversion by Nitric Oxide synthase of [3H]-L-arginine into [3H]-L-citrulline; Not active up to 100 microM ChEMBL. 12031315
IC50 (functional) 0 uM Antiproliferative activity was determined by colorimetric MTS assay in LNCaP cells after 72 h of incubation with compounds (1-100 uM); Not active at 100 uM ChEMBL. 15633998
IC50 (functional) = 0.62 uM PUBCHEM_BIOASSAY: AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2006, AID2011, AID2069, AID2614, AID2658] ChEMBL. No reference
IC50 (functional) = 2.4 uM Hypochlorous acid scavenging activity assessed as inhibition of DHR oxidation ChEMBL. 17624791
IC50 (binding) = 3.91 um PUBCHEM_BIOASSAY: Inhibitors of Mycobacterial Glucosamine-1-phosphate acetyl transferase (GlmU). Secondary screen. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 4.74 uM PUBCHEM_BIOASSAY: uHTS HTRF assay for identification of inhibitors of SUMOylation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2011, AID2018, AID2069, AID2614, AID2658] ChEMBL. No reference
IC50 (functional) 5.891 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 16.56 uM PUBCHEM_BIOASSAY: Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID782] ChEMBL. No reference
IC50 (functional) = 19.6 uM Neuroprotective effect was measured by its ability to protect mouse hippocampal neuronal HT-22 cell lines from oxidative stress caused by glutamate ChEMBL. 12031315
IC50 (functional) = 54.86 uM Antioxidant activity against formation of ROS was determined in t-BuOOH treated LNCaP cells after 24 h of incubation with compounds (1-100 uM) ChEMBL. 15633998
Inhibition (functional) = 13.1 % Inhibition of peroxynitrite-induced death of mixed cortical cells of E15 Sprague-Dawley rat embryo at 10 uM ChEMBL. 16640342
Inhibition (functional) = 14.8 % Inhibition of doxorubicin-induced death of mixed cortical cells of E15 Sprague-Dawley rat embryo at 10 uM ChEMBL. 16640342
Inhibition (functional) = 15.1 % Inhibition of hydrogen peroxide-induced death of mixed cortical cells of E15 Sprague-Dawley rat embryo at 10 uM ChEMBL. 16640342
Log Ki (binding) 0 Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]-prazosin to label cloned human alpha 1a expressed in CHO cells; Not tested ChEMBL. 15633998
Log Ki (binding) 0 Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]-prazosin to label cloned human alpha 1b expressed in CHO cells; Not tested ChEMBL. 15633998
Log Ki (binding) 0 Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]-prazosin to label cloned human alpha 1d expressed in CHO cells; Not tested ChEMBL. 15633998
Log Ki = 1.61 Lipophilicity, log k'w of the compound ChEMBL. 16640342
pA2 (functional) < 5 Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoreceptor) ChEMBL. 15633998
pA2 (functional) < 5 Blocking activity was assessed by antagonism of (-)-phenylephrine induced contraction of rat spleen (alpha1B adrenoreceptor) ChEMBL. 15633998
pA2 (functional) < 5 Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (alpha1D adrenoreceptor) ChEMBL. 15633998
Potency (functional) 0.0141 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0631 uM PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485290, AID485312, AID504464, AID504474] ChEMBL. No reference
Potency (functional) 0.1636 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 0.3444 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 0.3981 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.4775 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) [Related pubchem assays: 1705 (qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) ), 2324 (Probe Development Summary of Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1707 (Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Validation Assay), 2517 (qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1708 (Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV)] ChEMBL. No reference
Potency (functional) 0.7079 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) 1 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.7783 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 1.9953 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of retinoid X receptor alpha signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (binding) 2.8184 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 6.7016 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.5864 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 24.0151 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of peroxisome proliferator-activated receptor delta signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 27.5121 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 29.847 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.578 uM PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 48.5577 uM PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 48.9243 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 66.8242 uM PubChem BioAssay. qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 68.5199 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of peroxisome proliferator-activated receptor gamma signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

32 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.