Detailed information for compound 77382

Basic information

Technical information
  • TDR Targets ID: 77382
  • Name: 10-(4-butylphenyl)-3-methylbenzo[g]pteridine- 2,4-dione
  • MW: 360.409 | Formula: C21H20N4O2
  • H donors: 0 H acceptors: 2 LogP: 4.13 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCc1ccc(cc1)n1c2ccccc2nc2c1nc(=O)n(c2=O)C
  • InChi: 1S/C21H20N4O2/c1-3-4-7-14-10-12-15(13-11-14)25-17-9-6-5-8-16(17)22-18-19(25)23-21(27)24(2)20(18)26/h5-6,8-13H,3-4,7H2,1-2H3
  • InChiKey: JLAJYFGZSQCUQX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 10-(4-butylphenyl)-3-methyl-benzo[g]pteridine-2,4-dione
  • 10-(4-butylphenyl)-3-methyl-benzo[g]pteridine-2,4-quinone
  • AIDS050989
  • Benzo[g]pteridine-2,4(3H,10H)-dione, 10-(4-butylphenyl)-3-methyl-
  • AIDS-050989
  • NCI60_008996
  • NSC627985

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0167 0.087 0.3154
Onchocerca volvulus 0.0037 0.0039 0.0108
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0106 0.0476 0.0835
Echinococcus multilocularis PAK box P21 Rho binding 0.0057 0.0164 0.0129
Echinococcus granulosus unc 13 munc13 0.0042 0.0069 0.0113
Brugia malayi Protein kinase domain containing protein 0.0075 0.0282 0.0488
Loa Loa (eye worm) hypothetical protein 0.0059 0.018 0.0311
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0041 0.0242
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0059 0.018 0.0145
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0424 0.2511 0.8778
Brugia malayi Protein kinase domain containing protein 0.0144 0.0725 0.1272
Entamoeba histolytica diacylglycerol kinase, putative 0.0041 0.0061 0.0359
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0221 0.1214 0.2141
Giardia lamblia Kinase, AGC PKA 0.0147 0.0742 0.4975
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0093 0.0393 0.0359
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0144 0.0723 0.468
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0041 0.0228
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0339 0.1968 0.3475
Entamoeba histolytica protein kinase domain containing protein 0.0114 0.0527 0.3397
Echinococcus multilocularis calcium dependent protein kinase 0.0066 0.0225 0.019
Trichomonas vaginalis CAMK family protein kinase 0.0258 0.1453 0.4692
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0102 0.0455 0.0422
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0723 0.2618
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.019 0.1018 0.0986
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0059 0.018 0.1197
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0059 0.018 0.0145
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.013 0.0603
Brugia malayi casein kinase 1, delta 0.01 0.0442 0.0771
Trichomonas vaginalis AGC family protein kinase 0.0271 0.1537 0.4967
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0078 0.03 0.0266
Leishmania major protein kinase, putative 0.0144 0.0723 0.4954
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.0263 0.0834
Brugia malayi Variant SH3 domain containing protein 0.0052 0.0132 0.0223
Echinococcus multilocularis myotubularin protein 13 0.0047 0.01 0.0065
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0065 0.0218 0.0642
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0059 0.018 0.0505
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0041 0.0242
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.018 0.0636
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0136 0.0668 0.0635
Brugia malayi PAN domain containing protein 0.0037 0.0039 0.0059
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0065 0.0218 0.1464
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0114 0.0527 0.0925
Toxoplasma gondii AGC kinase 0.0065 0.0218 0.0603
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0141 0.0705 0.1241
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0047 0.0074
Echinococcus granulosus tyrosine protein kinase Fyn 0.0102 0.0455 0.1482
Onchocerca volvulus Serine\/threonine kinase homolog 0.0258 0.1453 0.4694
Loa Loa (eye worm) AGC/AKT protein kinase 0.0271 0.1537 0.2713
Echinococcus granulosus casein kinase I alpha 0.01 0.0442 0.1434
Echinococcus multilocularis tyrosine protein kinase Srms 0.0084 0.034 0.0306
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.1357 0.4933
Loa Loa (eye worm) hypothetical protein 0.0136 0.0668 0.1176
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0135 0.0667 0.2234
Brugia malayi PAN domain containing protein 0.0037 0.0039 0.0059
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.011 0.0505 0.1659
Brugia malayi C1-like domain containing protein 0.0207 0.1123 0.1978
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0102 0.0455 0.0422
Schistosoma mansoni protein kinase 0.0418 0.2477 0.9017
Echinococcus multilocularis casein kinase I gamma 0.0202 0.1096 0.1065
Trichomonas vaginalis CK1 family protein kinase 0.01 0.0442 0.1411
Schistosoma mansoni tyrosine kinase 0.0047 0.0102 0.0352
Loa Loa (eye worm) pyruvate kinase 0.0072 0.0263 0.0459
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0102
Echinococcus granulosus serine:threonine protein kinase 3 0.0245 0.1369 0.4724
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0614 0.1969
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0076 0.0286 0.1823
Brugia malayi glutaminase DH11.1 0.0267 0.1512 0.2665
Echinococcus granulosus tumor protein p63 0.0333 0.1934 0.673
Brugia malayi glutathione reductase 0.0047 0.0098 0.0164
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Echinococcus multilocularis rac serine:threonine kinase 0.0153 0.078 0.0748
Brugia malayi Immunoglobulin I-set domain containing protein 0.0379 0.2229 0.3935
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0041 0.0228
Trypanosoma cruzi cdc2-related kinase 3 0.011 0.0505 0.3446
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.013 0.0631 0.4319
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0147 0.0742 0.5083
Echinococcus granulosus calcium dependent protein kinase 0.0066 0.0225 0.0664
Onchocerca volvulus 0.0044 0.0084 0.0253
Echinococcus multilocularis mitogen activated protein kinase 11 0.015 0.0757 0.0725
Trichomonas vaginalis STE family protein kinase 0.0127 0.0614 0.1969
Trypanosoma cruzi casein kinase, putative 0.01 0.0442 0.3007
Trichomonas vaginalis AGC family protein kinase 0.0081 0.032 0.1017
Echinococcus granulosus roundabout 2 0.0071 0.0251 0.0759
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0108 0.0494 0.0864
Schistosoma mansoni loxhd1 0.0039 0.0046 0.015
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0227
Trichomonas vaginalis CMGC family protein kinase 0.013 0.0631 0.2027
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.011 0.0505 0.142
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0041 0.0159
Echinococcus multilocularis serine:threonine protein kinase 0.0106 0.0476 0.0442
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0187 0.0994 0.1753
Plasmodium falciparum calcium-dependent protein kinase 2 0.0093 0.0393 0.5251
Echinococcus granulosus RUN 0.0039 0.0046 0.0032
Echinococcus multilocularis rho associated protein kinase 0.0312 0.1796 0.1767
Toxoplasma gondii NEK kinase 0.0044 0.0079 0.0206
Entamoeba histolytica protein kinase, putative 0.0144 0.0725 0.4692
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0076 0.0286 0.1929
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0168 0.0464
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Trichomonas vaginalis AGC family protein kinase 0.0271 0.1537 0.4967
Echinococcus multilocularis nervana 2 0.0121 0.0574 0.054
Echinococcus granulosus expressed protein 0.0075 0.0282 0.0866
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.011 0.0505 0.0887
Leishmania major casein kinase, putative 0.01 0.0442 0.3007
Schistosoma mansoni serine/threonine protein kinase 0.0312 0.1796 0.6533
Loa Loa (eye worm) hypothetical protein 0.005 0.0117 0.0201
Echinococcus granulosus Glutaredoxin protein 5 0.0121 0.0574 0.1903
Giardia lamblia Kinase, AGC PKA 0.0065 0.0218 0.1277
Plasmodium vivax unspecified product 0.0092 0.0388 0.5232
Schistosoma mansoni cell adhesion molecule 0.006 0.0184 0.0652
Loa Loa (eye worm) raf kinase 0.0041 0.0061 0.0102
Plasmodium vivax glutathione reductase, putative 0.0047 0.0098 0.1326
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0075 0.0282 0.1902
Onchocerca volvulus 0.0312 0.1796 0.5807
Schistosoma mansoni serine/threonine protein kinase 0.0211 0.1152 0.4184
Loa Loa (eye worm) AUR protein kinase 0.0081 0.032 0.0559
Echinococcus multilocularis casein kinase i 0.01 0.0442 0.0408
Trichomonas vaginalis CAMK family protein kinase 0.0258 0.1453 0.4692
Echinococcus granulosus protein kinase shaggy 0.012 0.0567 0.1878
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0102 0.0455 0.1482
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0044 0.0079 0.0501
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0046 0.0091 0.0191
Onchocerca volvulus 0.0049 0.0112 0.0345
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0079 0.0269
Echinococcus granulosus N chimaerin 0.0052 0.0132 0.0336
Echinococcus granulosus serine:threonine protein kinase N2 0.0127 0.0611 0.2036
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0505 0.1823
Mycobacterium ulcerans hypothetical protein 0.0052 0.013 0.0603
Trypanosoma cruzi casein kinase, putative 0.01 0.0442 0.3007
Echinococcus multilocularis titin 0.0039 0.005 0.0015
Echinococcus multilocularis 0.0118 0.0555 0.0522
Brugia malayi protein kinase C3,putative 0.0148 0.0748 0.1314
Entamoeba histolytica protein kinase, putative 0.012 0.0567 0.366
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0074 0.0271 0.0474
Echinococcus multilocularis dual specificity 0.013 0.0631 0.0598
Echinococcus multilocularis dual specificity 0.0114 0.0527 0.0493
Echinococcus multilocularis pyruvate kinase 0.0057 0.0165 0.0131
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.01 0.0442 0.0775
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0144 0.0725 0.2439
Schistosoma mansoni protein kinase C mu 0.0041 0.0061 0.0205
Loa Loa (eye worm) hypothetical protein 0.0106 0.0476 0.0835
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0065 0.0218 0.1464
Echinococcus granulosus casein kinase I alpha 0.01 0.0442 0.1434
Brugia malayi Protein kinase domain containing protein 0.0432 0.2569 0.4535
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0059 0.018 0.0308
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.013 0.0603
Loa Loa (eye worm) AUR protein kinase 0.0081 0.032 0.0559
Echinococcus multilocularis neuroglian 0.0058 0.017 0.0135
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0075 0.0282 0.1902
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0388 0.2492
Loa Loa (eye worm) casein kinase 0.0176 0.0928 0.1635
Schistosoma mansoni hypothetical protein 0.0041 0.0061 0.0205
Onchocerca volvulus 0.0046 0.0096 0.0291
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0093 0.0393 0.0359
Echinococcus multilocularis hypothetical protein 0.006 0.0182 0.0148
Echinococcus multilocularis mitogen activated protein kinase 14 0.015 0.0757 0.0725
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0047 0.0102 0.0354
Echinococcus multilocularis nervana 2 0.0121 0.0574 0.054
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0227 0.1251 0.4307
Schistosoma mansoni protein kinase 0.0078 0.03 0.1074
Echinococcus multilocularis myosin iiia 0.0077 0.0291 0.0257
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0114 0.0527 0.3595
Toxoplasma gondii microneme protein MIC17C 0.0037 0.0039 0.0093
Brugia malayi Protein kinase domain containing protein 0.0144 0.0725 0.1272
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0047 0.0102 0.0354
Trichomonas vaginalis CMGC family protein kinase 0.0076 0.0286 0.0905
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0339 0.1968 0.3475
Echinococcus multilocularis dna polymerase eta 0.0063 0.0201 0.0167
Entamoeba histolytica p21-activated kinase 0.0084 0.0339 0.2169
Plasmodium vivax calcium-dependent protein kinase, putative 0.0093 0.0393 0.5293
Brugia malayi Temporarily assigned gene name protein 59 0.0109 0.0499 0.0873
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0118 0.0557 0.1785
Brugia malayi Protein kinase domain containing protein 0.019 0.1018 0.1791
Loa Loa (eye worm) hypothetical protein 0.0068 0.0236 0.0412
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0044 0.0079 0.0501
Echinococcus granulosus tyrosine kinase 0.0084 0.034 0.1074
Loa Loa (eye worm) hypothetical protein 0.006 0.0182 0.0316
Echinococcus granulosus NDR protein kinase 0.0144 0.0725 0.2439
Loa Loa (eye worm) hypothetical protein 0.0052 0.013 0.0224
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0093 0.0393 0.11
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.013 0.0855
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0078 0.03 0.0931
Giardia lamblia DINP protein human, muc B family 0.0038 0.0041 0.0028
Plasmodium falciparum NIMA related kinase 2 0.0044 0.0079 0.0985
Trypanosoma cruzi aurora B kinase, putative 0.0081 0.032 0.2167
Entamoeba histolytica protein kinase domain containing protein 0.013 0.0631 0.4081
Echinococcus granulosus mitogen activated protein kinase 14 0.015 0.0757 0.2555
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0093 0.0393 0.0688
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0481 0.8549
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.032 0.1148
Echinococcus granulosus pyruvate kinase 0.0072 0.0263 0.08
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0102 0.0455 0.0422
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0121 0.0574 0.1903
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0225 0.1243 0.1212
Brugia malayi Protein kinase c protein 2 0.0107 0.0486 0.0849
Echinococcus multilocularis Rac GTPase activating protein 1 0.0041 0.0061 0.0027
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0477 0.2855 1
Schistosoma mansoni tyrosine kinase 0.0058 0.0168 0.0593
Entamoeba histolytica protein kinase, putative 0.0075 0.0282 0.1797
Brugia malayi serine/threonine kinase 12 0.0081 0.032 0.0556
Echinococcus granulosus cyclin dependent kinase 0.011 0.0505 0.1659
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0505 0.1617
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0104 0.0358
Giardia lamblia Kinase, STE STE20 0.0078 0.03 0.1853
Brugia malayi AMP-binding enzyme family protein 0.0052 0.013 0.022
Loa Loa (eye worm) hypothetical protein 0.0118 0.0555 0.0975
Loa Loa (eye worm) hypothetical protein 0.007 0.0249 0.0434
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0102
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0076 0.0286 0.1929
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.013 0.0808
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0081 0.032 0.2047
Onchocerca volvulus 0.0063 0.02 0.0631
Brugia malayi Protein kinase domain containing protein 0.0202 0.1096 0.1929
Trichomonas vaginalis CK1 family protein kinase 0.01 0.0442 0.1411
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0065 0.0218 0.0642
Echinococcus granulosus protein kinase 0.0144 0.072 0.2422
Brugia malayi Protein kinase domain containing protein 0.0183 0.0974 0.1713
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0047 0.0104 0.0177
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0177
Schistosoma mansoni vam6/vps39 related 0.0109 0.0499 0.1801
Loa Loa (eye worm) hypothetical protein 0.0039 0.0048 0.0078
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0093 0.0393 0.11
Trypanosoma brucei NIMA-related protein kinase 0.0044 0.0079 0.0473
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0074 0.0438
Plasmodium vivax pyruvate kinase 2, putative 0.0037 0.0037 0.0506
Brugia malayi hypothetical protein 0.0109 0.0499 0.0873
Schistosoma mansoni tyrosine kinase 0.0113 0.0526 0.1899
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0481 0.8549
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0353 0.2057 0.7166
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0035 0.0109
Giardia lamblia Pyruvate kinase 0.0072 0.0263 0.1593
Brugia malayi probable protein kinase 0.0253 0.1419 0.2501
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0092 0.0388 0.068
Loa Loa (eye worm) hypothetical protein 0.0047 0.01 0.0171
Schistosoma mansoni unc-13 (munc13) 0.0042 0.0069 0.0234
Brugia malayi Protein kinase domain containing protein 0.0271 0.1537 0.271
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0265 0.1499 0.2645
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0318 0.1835 0.3241
Leishmania major protein kinase A catalytic subunit isoform 2 0.0065 0.0218 0.1464
Onchocerca volvulus Tyrosine kinase homolog 0.0332 0.1927 0.6231
Trichomonas vaginalis CMGC family protein kinase 0.013 0.0631 0.2027
Trichomonas vaginalis AGC family protein kinase 0.0074 0.0271 0.0859
Schistosoma mansoni hypothetical protein 0.006 0.0182 0.0646
Brugia malayi AMP-binding enzyme family protein 0.0052 0.013 0.022
Toxoplasma gondii hypothetical protein 0.0037 0.0039 0.0093
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0063
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0214 0.018
Echinococcus multilocularis aurora kinase A 0.0081 0.032 0.0286
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0078 0.03 0.0931
Brugia malayi hypothetical protein 0.0039 0.0046 0.0072
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.019 0.1018 0.3478
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0102 0.0455 0.0422
Toxoplasma gondii aurora kinase 0.0081 0.032 0.0892
Toxoplasma gondii AGC kinase 0.0065 0.0218 0.0603
Schistosoma mansoni unc-13 (munc13) 0.0042 0.0069 0.0234
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0388 0.1238
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0065 0.0218 0.2881
Loa Loa (eye worm) TK protein kinase 0.0084 0.034 0.0595
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0102 0.0455 0.0422
Loa Loa (eye worm) hypothetical protein 0.0084 0.0337 0.059
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0052 0.0132 0.0463
Loa Loa (eye worm) hypothetical protein 0.0039 0.0047 0.0076
Loa Loa (eye worm) TK/EPH protein kinase 0.0096 0.0416 0.073
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0353 0.2057 0.3632
Entamoeba histolytica protein kinase, putative 0.0094 0.04 0.2574
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.012 0.0567 0.1596
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0032 0.0007 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.1415 0.5144
Toxoplasma gondii PAN/Apple domain-containing protein 0.0037 0.0039 0.0093
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0108 0.0491 0.1608
Schistosoma mansoni tyrosine kinase 0.0037 0.004 0.0125
Brugia malayi STE20-like kinase MST 0.0245 0.1369 0.2412
Trichomonas vaginalis STE family protein kinase 0.0078 0.03 0.0951
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0144 0.0723 0.4954
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0115 0.0533 0.3639
Loa Loa (eye worm) hypothetical protein 0.0451 0.2687 0.4748
Brugia malayi MAP kinase sur-1 0.0076 0.0286 0.0495
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0078 0.03 0.0266
Trichomonas vaginalis pyruvate kinase, putative 0.0072 0.0263 0.0832
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0047 0.0629
Leishmania major protein kinase, putative 0.0043 0.0074 0.0464
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.012 0.0567 0.2048
Trichomonas vaginalis STE family protein kinase 0.0057 0.0164 0.0511
Brugia malayi Pyruvate kinase, M2 isozyme 0.0072 0.0263 0.0455
Entamoeba histolytica protein kinase 2, putative 0.0147 0.0742 0.4802
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Schistosoma mansoni vav2 0.0058 0.0171 0.0604
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.018 0.0636
Echinococcus granulosus serine:threonine protein kinase 0.0106 0.0476 0.1555
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0154 0.0788 0.0756
Trypanosoma cruzi casein kinase, delta isoform, putative 0.01 0.0442 0.3007
Entamoeba histolytica serine/threonine protein kinase, putative 0.0258 0.1453 0.9448
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0113 0.0526 0.0493
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0041 0.0006
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0076 0.0286 0.1929
Loa Loa (eye worm) hypothetical protein 0.0065 0.0214 0.0373
Leishmania major trypanothione reductase 0.0047 0.0098 0.0635
Echinococcus granulosus c-Jun N-terminal kinases 0.0252 0.1415 0.489
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0144 0.0723 0.4954
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0098 0.0635
Echinococcus multilocularis pyruvate kinase 0.0037 0.0037 0.0002
Loa Loa (eye worm) hypothetical protein 0.0109 0.0499 0.0876
Loa Loa (eye worm) TK/INSR protein kinase 0.0144 0.0723 0.1273
Plasmodium vivax SET domain protein, putative 0.0065 0.0214 0.2889
Echinococcus granulosus epidermal growth factor receptor 0.0074 0.0274 0.0839
Echinococcus multilocularis tumor protein p63 0.0333 0.1934 0.1905
Schistosoma mansoni protein kinase 0.0353 0.2057 0.7484
Echinococcus multilocularis casein kinase I alpha 0.01 0.0442 0.0408
Trypanosoma cruzi p21-activated kinase 3, putative 0.0047 0.0104 0.0671
Trichomonas vaginalis STE family protein kinase 0.0044 0.0079 0.0235
Giardia lamblia Kinase, PLK 0.0258 0.1453 1
Entamoeba histolytica protein kinase domain containing protein 0.0192 0.103 0.6683
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0102
Mycobacterium leprae Probable pyruvate kinase PykA 0.0072 0.0263 0.3111
Echinococcus multilocularis casein kinase ii subunit alpha 0.0092 0.0388 0.0354
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0039 0.0063
Echinococcus granulosus raf serine:threonine protein kinase 0.0057 0.0167 0.0461
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0552 0.1771
Schistosoma mansoni protein kinase 0.0081 0.032 0.1148
Leishmania major protein kinase A catalytic subunit isoform 1 0.0065 0.0218 0.1464
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0102
Onchocerca volvulus 0.0305 0.1754 0.567
Echinococcus multilocularis activin receptor type 0.0043 0.0074 0.0039
Loa Loa (eye worm) hypothetical protein 0.0072 0.0263 0.0459
Entamoeba histolytica casein kinase, putative 0.0092 0.0388 0.2492
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.005 0.0117 0.02
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.0079 0.0235
Schistosoma mansoni serine/threonine protein kinase 0.0165 0.0858 0.3112
Schistosoma mansoni protein kinase 0.01 0.0442 0.1591
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0074 0.0274 0.0839
Brugia malayi Protein kinase domain containing protein 0.0086 0.035 0.061
Trypanosoma brucei Serine/threonine-protein kinase NEK16, putative 0.0044 0.0079 0.0473
Echinococcus multilocularis serine:threonine protein kinase N2 0.0127 0.0611 0.0578
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0041 0.0132
Giardia lamblia Kinase, CAMK CAMKL 0.0059 0.018 0.1005
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0093 0.0393 0.2522
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0081 0.032 0.0286
Loa Loa (eye worm) hypothetical protein 0.008 0.031 0.0541
Trichomonas vaginalis AGC family protein kinase 0.0271 0.1537 0.4967
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0527 0.1901
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.013 0.0631 0.4319
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0286 0.1022
Loa Loa (eye worm) thyroid receptor interactor 0.0088 0.0364 0.0638
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0218 0.0777
Echinococcus granulosus dna polymerase eta 0.0063 0.0201 0.058
Giardia lamblia Aurora kinase 0.0081 0.032 0.1995
Echinococcus multilocularis cyclin dependent kinase 1 0.011 0.0505 0.0472
Trichomonas vaginalis STE family protein kinase 0.0078 0.03 0.0951
Plasmodium falciparum protein kinase, putative 0.0043 0.0074 0.0913
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0063 0.02 0.0348
Toxoplasma gondii pyruvate kinase PyK1 0.0072 0.0263 0.073
Brugia malayi Serine/threonine-protein kinase SULU 0.0211 0.1152 0.2029
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0109 0.0499 0.3217
Leishmania major protein kinase, putative 0.0077 0.0291 0.1969
Onchocerca volvulus 0.0514 0.3089 1
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0211 0.1152 0.1121
Onchocerca volvulus 0.0037 0.0039 0.0108
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0042 0.0069 0.0113
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0192 0.103 0.3521
Trypanosoma cruzi pyruvate kinase 2, putative 0.0072 0.0263 0.1773
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0165 0.0858 0.2913
Trypanosoma cruzi Serine/threonine-protein kinase NEK16, putative 0.0044 0.0079 0.0501
Echinococcus multilocularis expressed protein 0.0075 0.0282 0.0247
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.011 0.0505 0.0887
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0065 0.0218 0.0184
Onchocerca volvulus 0.0037 0.0039 0.0108
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.013 0.0631 0.111
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Trypanosoma brucei protein kinase, putative 0.0076 0.0286 0.1823
Plasmodium falciparum NIMA related kinase 4 0.0044 0.0079 0.0985
Loa Loa (eye worm) hypothetical protein 0.0109 0.0499 0.0876
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.018 0.0636
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0041 0.0113
Brugia malayi serine/threonine-protein kinase 6 0.0081 0.032 0.0556
Trichomonas vaginalis STE family protein kinase 0.0078 0.03 0.0951
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0041 0.0061 0.0102
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0093 0.0393 0.11
Giardia lamblia Kinase, CMGC GSK 0.012 0.0567 0.3739
Schistosoma mansoni serine/threonine protein kinase 0.0258 0.1453 0.5281
Schistosoma mansoni tyrosine kinase 0.0046 0.0091 0.0314
Chlamydia trachomatis pyruvate kinase 0.0072 0.0263 1
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0282 0.1008
Giardia lamblia Kinase, CAMK CAMKL 0.0059 0.018 0.1005
Schistosoma mansoni ste20-related kinase 0.0195 0.1045 0.3794
Trichomonas vaginalis STE family protein kinase 0.0078 0.03 0.0951
Brugia malayi SRC-1 0.0102 0.0455 0.0795
Trypanosoma brucei SNF1-related protein kinases, putative 0.0059 0.018 0.1131
Echinococcus granulosus nervana 2 0.0121 0.0574 0.1903
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0166 0.0862 0.1518
Brugia malayi RhoGEF domain containing protein 0.0041 0.0061 0.0098
Echinococcus multilocularis c src tyrosine kinase 0.0046 0.0091 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0788 0.2857
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0154 0.0788 0.1388
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.035 0.1259
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0388 0.1238
Echinococcus granulosus pyruvate kinase 0.0072 0.0263 0.08
Entamoeba histolytica protein kinase , putative 0.0081 0.032 0.2047
Brugia malayi Protein kinase domain containing protein 0.0183 0.0968 0.1703
Schistosoma mansoni protein kinase 0.0195 0.1047 0.3799
Echinococcus granulosus casein kinase I delta 0.01 0.0442 0.1434
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0388 0.1238
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0915 0.5656 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0047 0.0076
Toxoplasma gondii pyruvate kinase PyKII 0.0037 0.0037 0.0088
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0047 0.0104 0.0671
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0041 0.0014
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0043 0.0074 0.0191
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.013 0.0631 0.1779
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0144 0.0723 0.204
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0098 0.1326
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0218 0.0777
Trichomonas vaginalis CMGC family protein kinase 0.013 0.0631 0.2027
Echinococcus granulosus dual specificity 0.013 0.0631 0.2107
Leishmania major protein kinase, putative 0.0144 0.0723 0.4954
Schistosoma mansoni rap gtpase-activating protein 0.0109 0.0499 0.1801
Trypanosoma brucei pyruvate kinase 1, putative 0.0072 0.0263 0.1675
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0114 0.0527 0.3595
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0047 0.0546
Toxoplasma gondii hypothetical protein 0.0037 0.0039 0.0093
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0211 0.1152 0.2032
Echinococcus granulosus casein kinase ii subunit alpha 0.0092 0.0388 0.1244
Brugia malayi serine/threonine-protein kinase plk-2 0.0258 0.1453 0.2561
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0046 0.0076
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.013 0.0855
Echinococcus granulosus tyrosine protein kinase Blk 0.0084 0.034 0.1074
Brugia malayi Casein kinase II, alpha chain 0.0092 0.0388 0.0676
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0147 0.0742 0.2499
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0418 0.2477 0.8657
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0041 0.0067
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0081 0.032 0.1002
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.0201 0.1345
Onchocerca volvulus 0.0037 0.0039 0.0108
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0388 0.1238
Echinococcus granulosus defective proboscis extension response 0.0047 0.0102 0.023
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0214 0.0592
Plasmodium falciparum casein kinase 1 0.01 0.0442 0.5917
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0041 0.0228
Trichomonas vaginalis AGC family protein kinase 0.0074 0.0271 0.0859
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0227 0.1251 0.2207
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0192 0.103 0.1815
Trichomonas vaginalis AGC family protein kinase 0.0074 0.0271 0.0859
Brugia malayi jmjC domain containing protein 0.0058 0.0168 0.0287
Loa Loa (eye worm) hypothetical protein 0.0047 0.0102 0.0174
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0168 0.0594
Entamoeba histolytica PH domain containing protein kinase, putative 0.0153 0.078 0.5055
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0072 0.0263 0.4387
Echinococcus granulosus neuroglian 0.0058 0.017 0.0469
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0147 0.0738 0.2486
Loa Loa (eye worm) hypothetical protein 0.0039 0.0046 0.0076
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0258 0.1453 1
Echinococcus multilocularis cyclin dependent kinase 5 0.011 0.0505 0.0472
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.012 0.0567 0.3873
Trypanosoma cruzi polo-like protein kinase, putative 0.0258 0.1453 1
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0144 0.0725 0.1276
Plasmodium falciparum serine/threonine protein kinase 0.0075 0.0282 0.3741
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.013 0.1852
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0199 0.0573
Echinococcus multilocularis dual specificity protein kinase clk2 0.0144 0.0723 0.069
Toxoplasma gondii diacylglycerol kinase, putative 0.0041 0.0061 0.0157
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0039 0.0048 0.0013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0046 0.0076
Loa Loa (eye worm) CMGC/GSK protein kinase 0.012 0.0567 0.0996
Brugia malayi Kinase associated domain 1 family protein 0.006 0.0182 0.0312
Echinococcus multilocularis casein kinase I delta 0.01 0.0442 0.0408
Entamoeba histolytica protein kinase, putative 0.0078 0.03 0.1916
Loa Loa (eye worm) glutathione reductase 0.0047 0.0098 0.0168
Echinococcus multilocularis cyclin dependent kinase 0.011 0.0505 0.0472
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0144 0.072 0.1267
Brugia malayi PAN domain containing protein 0.0037 0.0039 0.0059
Giardia lamblia Kinase, CMGC GSK 0.012 0.0567 0.3739
Plasmodium falciparum calcium-dependent protein kinase 1 0.0093 0.0393 0.5251
Onchocerca volvulus 0.0042 0.0069 0.0206
Schistosoma mansoni DNA polymerase eta 0.0063 0.0201 0.0714
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.1232 0.4476
Trypanosoma cruzi cdc2-related kinase 1 0.011 0.0505 0.3446
Echinococcus multilocularis mitogen activated protein kinase 0.0076 0.0286 0.0251
Trichomonas vaginalis AGC family protein kinase 0.0271 0.1537 0.4967
Trypanosoma cruzi pyruvate kinase 2, putative 0.0072 0.0263 0.1773
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0388 0.1238
Echinococcus granulosus casein kinase I alpha 0.01 0.0442 0.1434
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0388 0.1238
Plasmodium falciparum calcium-dependent protein kinase 5 0.0093 0.0393 0.5251
Loa Loa (eye worm) hypothetical protein 0.028 0.1593 0.2812
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0227 0.1251 0.122
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0081 0.032 0.4313
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0257 0.1637
Onchocerca volvulus 0.0037 0.0039 0.0108
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0065 0.0218 0.0184
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0063
Trichomonas vaginalis CK1 family protein kinase 0.01 0.0442 0.1411
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0041 0.0228
Plasmodium falciparum serine/threonine protein kinase KIN 0.0059 0.018 0.2356
Loa Loa (eye worm) hypothetical protein 0.0187 0.0994 0.1752
Echinococcus granulosus serine:threonine protein kinase N2 0.0271 0.1536 0.5318
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0043 0.0074 0.0464
Echinococcus multilocularis 0.0144 0.072 0.0687
Entamoeba histolytica casein kinase 1, putative 0.01 0.0442 0.2841
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.005 0.0164
Echinococcus granulosus tyrosine protein kinase Fyn 0.0102 0.0455 0.1482
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0077 0.0291 0.1969
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.0263 0.0834
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0046 0.0543
Echinococcus multilocularis serine:threonine protein kinase 38 0.0144 0.0725 0.0692
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.035 0.1259
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.0201 0.1271
Plasmodium vivax pyruvate kinase, putative 0.0072 0.0263 0.3545
Schistosoma mansoni protein kinase C 0.0042 0.0069 0.0234
Trichomonas vaginalis pyruvate kinase, putative 0.0072 0.0263 0.0832
Trypanosoma brucei protein kinase, putative 0.0043 0.0074 0.0438
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.011 0.0505 0.0887
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0065 0.0218 0.0642
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0168 0.0594
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0039 0.0093
Leishmania major protein kinase, putative 0.0081 0.032 0.2167
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0098 0.0168
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0144 0.0725 0.0692
Trypanosoma cruzi NIMA-related kinase, putative 0.0044 0.0079 0.0501
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.013 0.0603
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0076 0.0286 0.1929
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0046 0.0091 0.0314
Loa Loa (eye worm) glutaminase 2 0.0267 0.1512 0.2668
Entamoeba histolytica protein kinase domain containing protein 0.012 0.0567 0.366
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0994 0.3608
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0224 0.1232 0.424
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0144 0.0723 0.1273
Loa Loa (eye worm) hypothetical protein 0.0052 0.013 0.0224
Schistosoma mansoni tyrosine kinase 0.0046 0.0091 0.0314
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0326 0.1884 0.3324
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0037 0.0039 0.0093
Loa Loa (eye worm) hypothetical protein 0.0227 0.1251 0.2207
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0725 0.2625
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.035 0.1259
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.1243 0.4514
Trypanosoma cruzi polo-like protein kinase, putative 0.0258 0.1453 1
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0039 0.0063
Brugia malayi Immunoglobulin I-set domain containing protein 0.0124 0.0593 0.104
Schistosoma mansoni ephrin receptor 0.0079 0.0306 0.1098
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0063
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0207 0.1123 0.1978
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0065 0.0218 0.1464
Plasmodium falciparum NIMA related kinase 1 0.0127 0.0614 0.8256
Echinococcus multilocularis dual specificity 0.013 0.0631 0.0598
Loa Loa (eye worm) hypothetical protein 0.0177 0.093 0.1639
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0102 0.0455 0.0422
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.013 0.0603
Schistosoma mansoni serine/threonine protein kinase 0.0165 0.0858 0.3112
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0052 0.0132 0.0463
Echinococcus multilocularis calcium activated potassium channel 0.0086 0.035 0.0316
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0214 0.0762
Plasmodium falciparum protein kinase 5 0.011 0.0505 0.678
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0108 0.0491 0.0457
Schistosoma mansoni tyrosine kinase 0.0074 0.0274 0.098
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0168 0.0594
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0557 1
Trichomonas vaginalis CAMK family protein kinase 0.0258 0.1453 0.4692
Brugia malayi Protein kinase domain containing protein 0.011 0.0505 0.0883
Brugia malayi Fes/CIP4 homology domain containing protein 0.0088 0.0364 0.0634
Loa Loa (eye worm) hypothetical protein 0.0039 0.0047 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.013 0.0631 0.2027
Trichomonas vaginalis AGC family protein kinase 0.0081 0.032 0.1017
Loa Loa (eye worm) AUR protein kinase 0.0081 0.032 0.0559
Echinococcus granulosus dual specificity protein kinase clk2 0.0144 0.0723 0.2433
Brugia malayi PAN domain containing protein 0.0037 0.0039 0.0059
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0074 0.0271 0.0474
Onchocerca volvulus 0.0037 0.0039 0.0108
Echinococcus granulosus protein kinase c epsilon type 0.0187 0.0994 0.3396
Entamoeba histolytica protein kinase, putative 0.0073 0.0269 0.1717
Giardia lamblia Kinase, STE STE20 0.0077 0.0291 0.1793
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0093 0.0393 0.126
Loa Loa (eye worm) SRC-1 0.0102 0.0455 0.0799
Plasmodium vivax tyrosine kinase-like protein, putative 0.0073 0.0268 0.362
Echinococcus granulosus geminin 0.0167 0.087 0.2954
Echinococcus multilocularis netrin receptor unc 5 0.0039 0.0047 0.0012
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0192 0.103 0.1812
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0379 0.2228 0.3936
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0102 0.0455 0.0422
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0127 0.0614 0.8272
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.018 0.0636
Plasmodium falciparum thioredoxin reductase 0.0047 0.0098 0.125
Brugia malayi RhoGAP domain containing protein 0.0041 0.0061 0.0098
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0076 0.0286 0.0499
Echinococcus multilocularis pyruvate kinase 0.0072 0.0263 0.0229
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0075 0.0282 0.0492
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0086 0.035 0.0613
Trichomonas vaginalis AGC family protein kinase 0.0271 0.1537 0.4967
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0065 0.0218 0.1383
Giardia lamblia Kinase, CK1 Casein kinase 0.01 0.0442 0.2854
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0214 0.0762
Trichomonas vaginalis AGC family protein kinase 0.0271 0.1537 0.4967
Echinococcus multilocularis dual specificity 0.013 0.0631 0.0598
Echinococcus multilocularis geminin 0.0167 0.087 0.0838
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0252 0.1415 0.2497
Echinococcus multilocularis casein kinase I alpha 0.01 0.0442 0.0408
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0041 0.0228
Echinococcus multilocularis serine:threonine protein kinase N2 0.0271 0.1536 0.1506
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0104 0.0358
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0039 0.0093
Onchocerca volvulus 0.0039 0.0046 0.0132
Loa Loa (eye worm) TK protein kinase 0.0073 0.0269 0.047
Brugia malayi Pre-SET motif family protein 0.0451 0.269 0.475
Loa Loa (eye worm) hypothetical protein 0.005 0.0117 0.0201
Brugia malayi Pleckstrin Homology Domain 0.0047 0.01 0.0167
Schistosoma mansoni lipoxygenase 0.0108 0.0491 0.177
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0041 0.0228
Echinococcus granulosus RNA directed DNA polymerase 0.0039 0.0048 0.0037
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0201 0.0345
Toxoplasma gondii microneme protein MIC17B 0.0037 0.0039 0.0093
Entamoeba histolytica PH domain containing protein kinase, putative 0.0153 0.078 0.5055
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0339 0.1968 0.3472
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0725 0.2625
Brugia malayi phosphoinositide-dependent protein kinase I 0.0074 0.0271 0.047
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0109 0.0499 0.3405
Trypanosoma brucei polo-like protein kinase 0.0258 0.1453 0.9448
Schistosoma mansoni protein kinase 0.0253 0.1419 0.5158
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.012 0.0567 0.3873
Loa Loa (eye worm) hypothetical protein 0.0065 0.0218 0.038
Loa Loa (eye worm) hypothetical protein 0.0049 0.0112 0.0192
Trichomonas vaginalis AGC family protein kinase 0.0151 0.0763 0.2456
Trichomonas vaginalis CMGC family protein kinase 0.013 0.0631 0.2027
Echinococcus multilocularis casein kinase I delta 0.01 0.0442 0.0408
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0052 0.0132 0.0097
Trypanosoma brucei pyruvate kinase 1 0.0072 0.0263 0.1675
Schistosoma mansoni protein kinase 0.0183 0.0968 0.3513
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0339 0.1968 0.6364
Entamoeba histolytica protein kinase, putative 0.0093 0.0393 0.2522
Toxoplasma gondii NEK kinase 0.0044 0.0079 0.0206
Echinococcus multilocularis serine:threonine protein kinase 3 0.0245 0.1369 0.1338
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0214 0.0762
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0041 0.0132
Plasmodium vivax glycogen synthase kinase 3, putative 0.012 0.0567 0.7641
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0114 0.0527 0.3595
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0144 0.0725 0.0692
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0075 0.0282 0.1797
Brugia malayi Protein kinase domain containing protein 0.0144 0.0723 0.1269
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0075 0.0282 0.0783
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.015 0.0757 0.1333
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.1243 0.4514
Giardia lamblia Kinase, NEK 0.0127 0.0614 0.407
Echinococcus granulosus fibroblast growth factor receptor 4 0.0113 0.0526 0.1733
Onchocerca volvulus 0.01 0.0442 0.1413
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0084 0.0049
Entamoeba histolytica cell division protein kinase 2, putative 0.011 0.0505 0.3256
Entamoeba histolytica protein kinase, putative 0.0271 0.1537 1
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0393 0.1413
Loa Loa (eye worm) hypothetical protein 0.005 0.0117 0.0201
Loa Loa (eye worm) hypothetical protein 0.0087 0.0358 0.0628
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0114 0.0527 0.3397
Toxoplasma gondii PAN domain-containing protein 0.0581 0.3518 1
Loa Loa (eye worm) glutaminase 0.0267 0.1512 0.2668
Brugia malayi Protein kinase domain containing protein 0.0087 0.0355 0.0618
Schistosoma mansoni kinase 0.0276 0.1568 0.5702
Toxoplasma gondii AGC kinase 0.0265 0.1499 0.425
Onchocerca volvulus 0.0065 0.0214 0.0676
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0214 0.018
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0041 0.0063
Onchocerca volvulus 0.018 0.0955 0.308
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.013 0.0603
Echinococcus granulosus dual specificity 0.013 0.0631 0.2107
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0147 0.0742 1
Schistosoma mansoni tyrosine kinase 0.0144 0.0723 0.2618
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0063
Loa Loa (eye worm) TK protein kinase 0.0124 0.0593 0.1043
Echinococcus granulosus mitogen activated protein kinase 3 0.0076 0.0286 0.088
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0113 0.0526 0.1733
Schistosoma mansoni glutaminase 0.0267 0.1512 0.5496
Echinococcus multilocularis epidermal growth factor receptor 0.0074 0.0274 0.024
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.013 0.0603
Loa Loa (eye worm) hypothetical protein 0.0116 0.0544 0.0956
Echinococcus granulosus dual specificity 0.013 0.0631 0.2107
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0046 0.0032
Plasmodium falciparum calcium-dependent protein kinase 4 0.0093 0.0393 0.5251
Echinococcus granulosus casein kinase I delta 0.01 0.0442 0.1434
Entamoeba histolytica protein kinase, putative 0.0081 0.032 0.2047
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0147 0.0742 0.0709
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0074 0.0271 0.083
Onchocerca volvulus 0.012 0.0567 0.1819
Echinococcus multilocularis pyruvate kinase 0.0037 0.0037 0.0002
Toxoplasma gondii NEK kinase 0.0044 0.0079 0.0206
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0192 0.103 0.0998
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0059 0.018 0.1197
Loa Loa (eye worm) TK/EGFR protein kinase 0.0074 0.0274 0.0478
Echinococcus multilocularis protein kinase c epsilon type 0.0187 0.0994 0.0963
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0168 0.0464
Schistosoma mansoni rab6-interacting 0.0039 0.0046 0.015
Onchocerca volvulus 0.0074 0.0273 0.0868
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0076 0.0286 0.0795
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0379 0.2228 0.2201
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0258 0.1453 0.2564
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0117 0.0197
Trypanosoma brucei trypanothione reductase 0.0047 0.0098 0.06
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0065 0.0218 0.0376
Entamoeba histolytica protein kinase, putative 0.0057 0.0164 0.1029
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0046 0.0032
Brugia malayi protein unc-22 0.0039 0.005 0.0078
Loa Loa (eye worm) pyruvate kinase-PB 0.005 0.0123 0.0211
Brugia malayi Protein kinase domain containing protein 0.0114 0.0527 0.0921
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0195 0.1047 0.3581
Onchocerca volvulus 0.0037 0.0039 0.0108
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0039 0.005 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0132 0.0406
Trichomonas vaginalis AGC family protein kinase 0.0081 0.032 0.1017
Trichomonas vaginalis AGC family protein kinase 0.0081 0.032 0.1017
Loa Loa (eye worm) CMGC/GSK protein kinase 0.012 0.0567 0.0996
Onchocerca volvulus Serine\/threonine kinase homolog 0.0154 0.0788 0.2538
Leishmania major pyruvate kinase 0.0072 0.0263 0.1773
Trypanosoma cruzi casein kinase II, putative 0.0092 0.0388 0.2638
Loa Loa (eye worm) pyruvate kinase 0.0072 0.0263 0.0459
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0077 0.0291 0.186
Echinococcus granulosus casein kinase i 0.01 0.0442 0.1434
Plasmodium falciparum pyruvate kinase 0.0072 0.0263 0.3488
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0217 0.0772
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0477 0.2855 0.283
Loa Loa (eye worm) hypothetical protein 0.0136 0.0668 0.1176
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0505 0.1823
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0552 0.1771
Trypanosoma brucei protein kinase, putative 0.012 0.0567 0.366
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0041 0.0159
Plasmodium falciparum pyruvate kinase 2 0.0037 0.0037 0.0421
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0065 0.0218 0.0603
Echinococcus granulosus myotubularin protein 13 0.0047 0.01 0.0223
Brugia malayi hypothetical protein 0.0211 0.1152 0.2029
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0034 0.0079
Onchocerca volvulus 0.0109 0.0499 0.16
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Schistosoma mansoni tyrosine kinase 0.0074 0.0274 0.098
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0102 0.0455 0.1482
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0068 0.0234 0.02
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0039 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0258 0.1453 0.4692
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0451 0.269 0.4752
Loa Loa (eye worm) hypothetical protein 0.0058 0.0169 0.0293
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0084 0.034 0.1074
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0211 0.1152 0.3956
Brugia malayi PAN domain containing protein 0.0037 0.0039 0.0059
Entamoeba histolytica protein kinase, putative 0.0114 0.0527 0.3397
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0034 0.0192
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0047 0.0104 0.0173
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0046 0.0011
Brugia malayi serine/threonine protein kinase 6 0.0081 0.032 0.0556
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0339 0.1968 0.6851
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0041 0.0242
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0093 0.0393 0.126
Trichomonas vaginalis CMGC family protein kinase 0.0076 0.0286 0.0905
Giardia lamblia Kinase, CMGC SRPK 0.0075 0.0282 0.1724
Schistosoma mansoni tyrosine kinase 0.0102 0.0455 0.1641
Leishmania major protein kinase A catalytic subunit 0.0065 0.0218 0.1464
Toxoplasma gondii microneme protein MIC17A 0.0037 0.0039 0.0093
Trichomonas vaginalis glutaminase, putative 0.0267 0.1512 0.4884
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0066 0.0224 0.039
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Brugia malayi Pre-SET motif family protein 0.0065 0.0214 0.0369
Schistosoma mansoni tyrosine kinase 0.0058 0.0168 0.0593
Toxoplasma gondii microneme protein MIC4 0.0037 0.0039 0.0093
Plasmodium vivax serine/threonine kinase-1, putative 0.0144 0.0723 0.9748
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0112 0.039
Toxoplasma gondii subtilisin SUB12 0.0037 0.0039 0.0093
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.0263 0.0834
Onchocerca volvulus 0.0037 0.0039 0.0108
Brugia malayi Protein kinase domain containing protein 0.0106 0.0476 0.0831
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0481 0.8219
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0481 0.8549
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0041 0.0242
Brugia malayi Protein kinase domain containing protein 0.0353 0.2057 0.363
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0077 0.0291 0.186
Echinococcus multilocularis cyclin dependent kinase 1 0.011 0.0505 0.0472
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.01 0.0442 0.0775
Brugia malayi hypothetical protein 0.0033 0.0012 0.001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0047 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Giardia lamblia Kinase, NEK 0.0044 0.0079 0.0293
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0165 0.0858 0.0826
Trichomonas vaginalis AGC family protein kinase 0.0144 0.0725 0.233
Trichomonas vaginalis AGC family protein kinase 0.0144 0.0725 0.233
Schistosoma mansoni hypothetical protein 0.006 0.0182 0.0646
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0102
Echinococcus multilocularis RNA directed DNA polymerase 0.0039 0.0048 0.0013
Schistosoma mansoni hypothetical protein 0.0167 0.087 0.3154
Brugia malayi map kinase activated protein kinase protein 2 0.0379 0.2228 0.3933
Onchocerca volvulus 0.0037 0.0039 0.0108
Schistosoma mansoni serine/threonine kinase 0.0086 0.035 0.1259
Giardia lamblia Kinase, CMGC CK2 0.0092 0.0388 0.2477
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.013 0.0603
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0245 0.1369 0.2415
Schistosoma mansoni nephrin 0.006 0.0185 0.0654
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0041 0.0228
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0059 0.018 0.1197
Loa Loa (eye worm) hypothetical protein 0.0109 0.0499 0.0876
Echinococcus multilocularis casein kinase I alpha 0.01 0.0442 0.0408
Trichomonas vaginalis CMGC family protein kinase 0.013 0.0631 0.2027
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.0723 0.2324
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0059 0.018 0.0311
Onchocerca volvulus Netrin receptor homolog 0.0039 0.0048 0.0137
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0047 0.0104 0.0177
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.013 0.0808
Entamoeba histolytica protein kinase, putative 0.013 0.0631 0.4081
Loa Loa (eye worm) pyruvate kinase 0.0072 0.0263 0.0459
Echinococcus granulosus Vam6:Vps39 protein 0.0109 0.0499 0.1638
Brugia malayi Protein kinase domain containing protein 0.0915 0.5656 1
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.015 0.0757 0.4904
Giardia lamblia Kinase, CMGC DYRK 0.013 0.0631 0.4195
Plasmodium falciparum calcium-dependent protein kinase 3 0.0093 0.0393 0.5251
Trichomonas vaginalis CMGC family protein kinase 0.0076 0.0286 0.0905
Trichomonas vaginalis STE family protein kinase 0.0077 0.0291 0.0924
Echinococcus multilocularis N chimaerin 0.0052 0.0132 0.0097
Echinococcus multilocularis pyruvate kinase 0.0037 0.0037 0.0002
Trypanosoma cruzi casein kinase, putative 0.01 0.0442 0.3007
Schistosoma mansoni protein kinase 0.0418 0.2477 0.9017
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.005 0.0078
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0257 0.1637
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0077 0.0291 0.1969
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0144 0.0723 0.4954
Entamoeba histolytica pyruvate kinase, putative 0.005 0.0123 0.076
Entamoeba histolytica cell division protein kinase 2, putative 0.011 0.0505 0.3256
Echinococcus multilocularis insulin receptor 0.0144 0.0723 0.069
Schistosoma mansoni protein kinase 0.0195 0.1047 0.3799
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.011 0.0505 0.3446
Schistosoma mansoni serine/threonine-protein kinase 0.0153 0.078 0.2828
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0041 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.103 0.3737
Brugia malayi Protein kinase domain containing protein 0.0144 0.0723 0.1269
Leishmania major protein kinase, putative,serine/threonine-protein kinase Nek1, putative 0.0044 0.0079 0.0501
Loa Loa (eye worm) RasGEF domain-containing protein 0.0041 0.0061 0.0102
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0144 0.0725 0.2439
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0102 0.0455 0.0422
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0046 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Trypanosoma brucei casein kinase I, isoform 2 0.01 0.0442 0.2841
Echinococcus multilocularis serine:threonine protein kinase 0.0106 0.0476 0.0442
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0047 0.0257
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0168 0.0134
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0059 0.018 0.0311
Giardia lamblia Kinase, CMGC CDK 0.011 0.0505 0.3303
Schistosoma mansoni serine/threonine protein kinase 0.0379 0.2228 0.811
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0227 0.1251 0.4307
Brugia malayi PAN domain containing protein 0.0037 0.0039 0.0059
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0093 0.0393 0.126
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0047 0.0102 0.0067
Toxoplasma gondii thioredoxin reductase 0.0047 0.0098 0.0262
Trichomonas vaginalis set domain proteins, putative 0.0514 0.3089 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0058 0.0169 0.0467
Schistosoma mansoni serine/threonine protein kinase 0.0271 0.1536 0.5585
Loa Loa (eye worm) hypothetical protein 0.0136 0.0668 0.1176
Brugia malayi Protein kinase domain containing protein 0.0055 0.0149 0.0253
Loa Loa (eye worm) AGC/PKA protein kinase 0.0065 0.0218 0.038
Plasmodium falciparum glutathione reductase 0.0047 0.0098 0.125
Entamoeba histolytica diacylglycerol kinase, putative 0.0041 0.0061 0.0359
Brugia malayi serine/threonine-protein kinase PAK 7 0.0221 0.1214 0.2138
Toxoplasma gondii histone kinase SNF1, putative 0.0059 0.018 0.0493
Schistosoma mansoni protein kinase 0.0043 0.0074 0.0249
Brugia malayi PAN domain containing protein 0.0037 0.0039 0.0059
Mycobacterium ulcerans pyruvate kinase 0.0072 0.0263 0.1506
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.035 0.1115
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0063
Echinococcus multilocularis protein kinase c eta type 0.0041 0.0061 0.0027
Giardia lamblia Kinase, NEK 0.0127 0.0614 0.407
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0039 0.0093
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0047 0.0104 0.0315
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0165 0.0858 0.2913
Echinococcus multilocularis mitogen activated protein kinase 11 0.015 0.0757 0.0725
Schistosoma mansoni protein kinase 0.0057 0.0164 0.0579
Plasmodium falciparum protein serine/threonine kinase-1 0.0144 0.0723 0.9746
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0557 1
Entamoeba histolytica protein kinase, putative 0.0063 0.0203 0.1282
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0505 0.1617
Loa Loa (eye worm) AGC/PKN protein kinase 0.0271 0.1536 0.2711
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.013 0.0855
Leishmania major pyruvate kinase 0.0072 0.0263 0.1773
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0041 0.0228
Echinococcus multilocularis epidermal growth factor receptor 0.0074 0.0274 0.024
Loa Loa (eye worm) hypothetical protein 0.0047 0.0102 0.0174
Brugia malayi hypothetical protein 0.0039 0.0046 0.0072
Schistosoma mansoni tyrosine kinase 0.0144 0.0723 0.2618
Brugia malayi Doublecortin family protein 0.0141 0.0705 0.1238
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0147 0.0738 0.0706
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.013 0.0631 0.4081
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0041 0.0113
Plasmodium falciparum glycogen synthase kinase 3 0.012 0.0567 0.762
Echinococcus granulosus serine:threonine protein kinase 0.0106 0.0476 0.1555
Entamoeba histolytica protein kinase domain containing protein 0.0081 0.032 0.2047
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0043 0.0074 0.0464
Echinococcus granulosus tyrosine protein kinase Src42A 0.0068 0.0234 0.0698
Echinococcus granulosus netrin receptor unc 5 0.0039 0.0047 0.0035
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.013 0.0631 0.1107
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0165 0.0858 0.0826
Trypanosoma cruzi casein kinase, putative 0.01 0.0442 0.3007
Trypanosoma brucei Casein kinase II 0.0092 0.0388 0.2492
Echinococcus multilocularis Immunoglobulin 0.0047 0.0102 0.0067
Schistosoma mansoni vesicular amine transporter 0.0047 0.0102 0.0354
Toxoplasma gondii microneme protein, putative 0.0037 0.0039 0.0093
Echinococcus granulosus epidermal growth factor receptor 0.0074 0.0274 0.0839
Echinococcus multilocularis unc 13 (munc13) 0.0042 0.0069 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0218 0.0777
Entamoeba histolytica protein kinase, putative 0.0074 0.0271 0.173
Echinococcus granulosus Diacylglycerol kinase theta 0.0041 0.0061 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0167 0.0591
Brugia malayi Protein kinase domain containing protein 0.0154 0.0788 0.1385
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0476 0.1522
Echinococcus multilocularis serine threonine protein kinase 0.0184 0.0981 0.0949
Echinococcus multilocularis mitogen activated protein kinase 3 0.0076 0.0286 0.0251
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0092 0.0388 0.5232
Brugia malayi Cam kinase protein 1 0.0093 0.0393 0.0684
Echinococcus multilocularis RUN 0.0039 0.0046 0.0011
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0557 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0557 1
Entamoeba histolytica protein kinase, putative 0.0114 0.0527 0.3397
Brugia malayi jmjC domain containing protein 0.0058 0.0168 0.0287
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0093 0.0393 0.0688
Echinococcus granulosus Rac GTPase activating protein 1 0.0041 0.0061 0.0085
Entamoeba histolytica casein kinase, putative 0.01 0.0442 0.2841
Brugia malayi Ras association domain family 1 isoform A 0.0041 0.0061 0.0098
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0081 0.032 0.2047
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.018 0.0636
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.012 0.0567 0.0534
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0076 0.0286 0.1929
Brugia malayi PAN domain containing protein 0.0037 0.0039 0.0059
Trypanosoma cruzi casein kinase, putative 0.01 0.0442 0.3007
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0041 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.1232 0.4476
Schistosoma mansoni serine/threonine-protein kinase 0.0153 0.078 0.2828
Brugia malayi Fibronectin type III domain containing protein 0.005 0.0117 0.0197
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0039 0.0063
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.015 0.0757 0.5191
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0326 0.1884 0.3327
Entamoeba histolytica protein kinase, putative 0.0037 0.0038 0.0209
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0258 0.1453 0.1423
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0073 0.0268 0.3563
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0039 0.0063
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0113 0.0526 0.0493
Brugia malayi putative serine/threonine kinase SADA gamma 0.0059 0.018 0.0308
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0631 0.2284
Echinococcus multilocularis raf serine:threonine protein kinase 0.0057 0.0167 0.0133
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0077 0.0291 0.186
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0052 0.0132 0.0227
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0252 0.1415 0.1385
Loa Loa (eye worm) CAMK protein kinase 0.0039 0.005 0.0082
Entamoeba histolytica serine/threonine protein kinase, putative 0.0044 0.0079 0.0473
Loa Loa (eye worm) AGC/NDR protein kinase 0.0144 0.0725 0.1276
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0065 0.0218 0.1383
Onchocerca volvulus 0.0039 0.005 0.0144
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0271 0.0971
Echinococcus granulosus protein kinase c iota type 0.0266 0.1505 0.5209
Schistosoma mansoni protein kinase 0.0144 0.072 0.2607
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0052 0.0132 0.0336
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0102 0.0455 0.0422
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0065 0.0218 0.1464
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0078 0.03 0.0266
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.0079 0.0235
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0144 0.0723 0.4954
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0041 0.0228
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0076 0.0286 0.1929
Leishmania major protein kinase, putative 0.0044 0.0079 0.0501
Schistosoma mansoni titin 0.0039 0.005 0.0164
Giardia lamblia Kinase, CMGC MAPK 0.0076 0.0286 0.1752
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0065 0.0218 0.0184
Trichomonas vaginalis CAMK family protein kinase 0.0258 0.1453 0.4692
Trypanosoma brucei cdc2-related kinase 1 0.011 0.0505 0.3256
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0093 0.0393 0.0684
Giardia lamblia Kinase, CMGC CDK 0.011 0.0505 0.3303
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0339 0.1968 0.194
Echinococcus granulosus nervana 2 0.0121 0.0574 0.1903
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0046 0.0626
Onchocerca volvulus 0.0052 0.013 0.0403
Entamoeba histolytica serine/threonine protein kinase, putative 0.0059 0.018 0.1131
Trichomonas vaginalis CAMK family protein kinase 0.0258 0.1453 0.4692
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0135 0.0667 0.0634
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.015 0.0757 0.5191
Trypanosoma brucei Serine/threonine-protein kinase NEK11, putative 0.0044 0.0079 0.0473
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0481 0.8549
Plasmodium vivax casein kinase 1, putative 0.01 0.0442 0.5953
Echinococcus granulosus hypothetical protein 0.0118 0.0555 0.1836
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0214 0.0762
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0081 0.032 0.2047
Echinococcus granulosus Immunoglobulin 0.0047 0.0102 0.023
Trypanosoma cruzi cdc2-related kinase 3 0.011 0.0505 0.3446
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0059 0.018 0.2423
Brugia malayi Hr1 repeat family protein 0.0271 0.1536 0.2708
Brugia malayi Thioredoxin reductase 0.0047 0.0098 0.0164
Echinococcus granulosus ephrin type A receptor 4 A 0.0079 0.0306 0.0954
Echinococcus granulosus cyclin dependent kinase 5 0.011 0.0505 0.1659
Schistosoma mansoni protein kinase 0.0078 0.03 0.1074
Echinococcus multilocularis pyruvate kinase 0.0072 0.0263 0.0229
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0093 0.0393 0.0359
Schistosoma mansoni pyruvate kinase 0.0037 0.0037 0.0117
Schistosoma mansoni pyruvate kinase 0.0072 0.0263 0.094
Echinococcus granulosus aurora kinase A 0.0081 0.032 0.1002
Echinococcus granulosus cyclin dependent kinase 1 0.011 0.0505 0.1659
Onchocerca volvulus 0.0037 0.0039 0.0108
Echinococcus granulosus titin 0.0039 0.005 0.0045
Echinococcus granulosus glycogen synthase kinase 3 beta 0.012 0.0567 0.1878
Entamoeba histolytica protein kinase, putative 0.0075 0.0282 0.1797
Brugia malayi AMP-binding enzyme family protein 0.0052 0.013 0.022
Loa Loa (eye worm) AGC/PKA protein kinase 0.0065 0.0218 0.038
Trypanosoma brucei cdc2-related kinase 3 0.011 0.0505 0.3256
Echinococcus granulosus c src tyrosine kinase 0.0046 0.0091 0.0191
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0065 0.0218 0.2943
Brugia malayi ephrin receptor 1 precursor 0.0046 0.0094 0.0157
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0109 0.0499 0.3405
Brugia malayi Stress-activated protein kinase jnk-1 0.0252 0.1415 0.2494
Brugia malayi P38 map kinase family protein 2 0.015 0.0757 0.133
Trypanosoma brucei RNA helicase, putative 0.0104 0.0467 0.3006
Onchocerca volvulus 0.014 0.0694 0.2231
Loa Loa (eye worm) hypothetical protein 0.0093 0.0393 0.0688
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0059 0.018 0.1131
Trypanosoma brucei aurora B kinase 0.0081 0.032 0.2047
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.0079 0.0235
Trichomonas vaginalis AGC family protein kinase 0.0271 0.1537 0.4967
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0039 0.0093
Giardia lamblia Kinase, AGC AKT 0.0108 0.0494 0.3226
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0073 0.0268 0.0746
Echinococcus multilocularis protein kinase c iota type 0.0266 0.1505 0.1475
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.013 0.1852
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0102
Loa Loa (eye worm) hypothetical protein 0.014 0.0694 0.1221
Trichomonas vaginalis CAMK family protein kinase 0.0258 0.1453 0.4692
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0084 0.0165
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0041 0.0242
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0041 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0218 0.0687
Entamoeba histolytica protein kinase, putative 0.0271 0.1537 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.011 0.0505 0.3446
Leishmania major DNA polymerase kappa, putative 0.0038 0.0041 0.0242
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0136 0.0668 0.2237
Entamoeba histolytica protein kinase, putative 0.0081 0.032 0.2047
Echinococcus multilocularis serine:threonine protein kinase N2 0.0144 0.0725 0.0692
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0195 0.1047 0.1015
Echinococcus multilocularis Glutaredoxin protein 5 0.0121 0.0574 0.054
Brugia malayi Protein kinase domain containing protein 0.0074 0.0271 0.047
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0505 0.1617
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0037 0.0038 0.0209
Schistosoma mansoni tyrosine kinase 0.0102 0.0455 0.1641
Brugia malayi diacylglycerol kinase 0.0041 0.0061 0.0098
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0014
Echinococcus granulosus protein kinase c eta type 0.0041 0.0061 0.0085
Brugia malayi Temporarily assigned gene name protein 59 0.0126 0.0607 0.1064
Onchocerca volvulus 0.0187 0.0994 0.3205
Brugia malayi protein kinase C II. 0.0187 0.0994 0.1749
Toxoplasma gondii casein kinase I 0.01 0.0442 0.1239
Echinococcus granulosus activin receptor type 0.0043 0.0074 0.0128
Schistosoma mansoni hypothetical protein 0.0039 0.0046 0.015
Brugia malayi PAN domain containing protein 0.0037 0.0039 0.0059
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0074 0.0271 0.0237
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0127 0.0614 0.1729
Echinococcus granulosus tyrosine protein kinase Lyn 0.0129 0.0623 0.2079
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.01 0.0442 0.0775
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0432 0.2569 0.4538
Echinococcus granulosus protein kinase C gamma type 0.0184 0.0981 0.3348
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0041 0.0228
Brugia malayi hypothetical protein 0.005 0.0117 0.0197
Echinococcus granulosus tyrosine protein kinase Src42A 0.0102 0.0455 0.1482
Loa Loa (eye worm) hypothetical protein 0.018 0.0955 0.1684
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0046 0.0091 0.0056
Brugia malayi RhoGAP domain containing protein 0.0052 0.0132 0.0223
Trichomonas vaginalis CMGC family protein kinase 0.012 0.0567 0.1818
Loa Loa (eye worm) hypothetical protein 0.0039 0.0047 0.0076
Brugia malayi Doublecortin family protein 0.0044 0.0084 0.0138
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0109 0.0499 0.1801
Echinococcus granulosus mitogen activated protein kinase 0.0076 0.0286 0.088
Schistosoma mansoni polycystin 1-related 0.0039 0.0046 0.015
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0059 0.018 0.1197
Schistosoma mansoni serine/threonine protein kinase 0.046 0.2746 1
Schistosoma mansoni lipoxygenase 0.0039 0.0046 0.015
Giardia lamblia Kinase, NEK 0.0127 0.0614 0.407
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0183 0.0968 0.1706
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Entamoeba histolytica protein kinase domain containing protein 0.012 0.0567 0.366
Echinococcus granulosus Protein kinase C brain isozyme 0.0225 0.1243 0.4276
Onchocerca volvulus 0.0136 0.0668 0.2148
Brugia malayi cell division control protein 2 homolog 0.011 0.0505 0.0883
Echinococcus multilocularis protein kinase shaggy 0.012 0.0567 0.0534
Schistosoma mansoni protein kinase 0.0418 0.2477 0.9017
Echinococcus multilocularis ephrin type A receptor 4 A 0.0079 0.0306 0.0272
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0109 0.0499 0.1801
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0388 0.1238
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.0349
Entamoeba histolytica protein kinase, putative 0.0265 0.1499 0.9747
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.013 0.0808
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0153 0.078 0.5351
Plasmodium falciparum casein kinase 2, alpha subunit 0.0092 0.0388 0.5189
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0207 0.1123 0.1981
Loa Loa (eye worm) hypothetical protein 0.0039 0.0047 0.0076
Plasmodium vivax serine/threonine protein kinase, putative 0.0075 0.0282 0.3796
Echinococcus granulosus serine threonine protein kinase nrc 0.0147 0.0742 0.2499
Schistosoma mansoni rab6-interacting 0.0039 0.0046 0.015
Schistosoma mansoni protein kinase 0.0092 0.0388 0.1396
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0154 0.0788 0.2665
Loa Loa (eye worm) protein kinase domain-containing protein 0.0202 0.1096 0.1932
Leishmania major serine/threonine-protein kinase, putative 0.0044 0.0079 0.0501
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0418 0.2477 0.2451
Echinococcus multilocularis tyrosine protein kinase HCK 0.0073 0.0269 0.0235
Brugia malayi Furin-like cysteine rich region family protein 0.0074 0.0274 0.0474
Echinococcus granulosus mitogen activated protein kinase 11 0.015 0.0757 0.2555
Brugia malayi protein-tyrosine kinase 0.0084 0.034 0.0591
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0041 0.0228
Schistosoma mansoni atypical protein kinase C 0.0272 0.1543 0.5611
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0224 0.1232 0.1201
Mycobacterium tuberculosis Probable reductase 0.0106 0.0481 0.8549
Plasmodium falciparum serine/threonine protein kinase, putative 0.0081 0.032 0.4262
Brugia malayi casein kinase I 0.01 0.0442 0.0771
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0078 0.03 0.0931
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0379 0.2229 0.3937
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0098 0.0064
Echinococcus granulosus casein kinase I gamma 0.0202 0.1096 0.3756
Onchocerca volvulus 0.0286 0.1628 0.5262
Echinococcus granulosus tyrosine protein kinase Src64B 0.0102 0.0455 0.1482
Schistosoma mansoni serine/threonine protein kinase 0.0339 0.1968 0.716
Trypanosoma brucei unspecified product 0.0038 0.0041 0.0228
Brugia malayi diacylglycerol kinase 0.0041 0.0061 0.0098
Trypanosoma brucei rac serine-threonine kinase, putative 0.0271 0.1537 1
Schistosoma mansoni serine/threonine kinase 0.0144 0.0725 0.2625
Loa Loa (eye worm) hypothetical protein 0.0052 0.013 0.0224
Trichomonas vaginalis CMGC family protein kinase 0.012 0.0567 0.1818
Toxoplasma gondii PAN domain-containing protein 0.0581 0.3518 1
Leishmania major DNA polymerase eta, putative 0.0063 0.0201 0.1345
Echinococcus granulosus twitchin 0.0084 0.0338 0.1065
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0168 0.0134
Echinococcus granulosus dual specificity 0.0114 0.0527 0.1735
Schistosoma mansoni hypothetical protein 0.0109 0.0499 0.1801
Echinococcus granulosus rho-associated protein kinase 1 0.0312 0.1796 0.6241
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0214 0.0627
Plasmodium vivax serine/threonine-protein kinase Nek1, putative 0.0044 0.0079 0.1064
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0723 0.2618
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0043 0.0074 0.0438
Loa Loa (eye worm) hypothetical protein 0.0068 0.0236 0.0412
Schistosoma mansoni serine/threonine protein kinase 0.019 0.1018 0.3694
Leishmania major casein kinase II, putative 0.0092 0.0388 0.2638
Schistosoma mansoni tyrosine kinase 0.0058 0.0168 0.0593
Schistosoma mansoni protein kinase C mu 0.0207 0.1123 0.4079
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0154 0.0786 0.1385
Echinococcus multilocularis roundabout 2 0.0071 0.0251 0.0217
Brugia malayi p70 ribosomal S6 kinase beta 0.0265 0.1499 0.2642
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0032 0.0006 0.0004
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0039 0.005 0.0015
Mycobacterium ulcerans glutaminase 0.0267 0.1512 1
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0147 0.0742 1
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.0079 0.0235
Schistosoma mansoni netrin receptor unc5 0.0039 0.0047 0.0154
Brugia malayi intracellular kinase 0.012 0.0567 0.0993
Echinococcus granulosus tyrosine protein kinase HCK 0.0073 0.0269 0.0823
Brugia malayi Pyruvate kinase, muscle isozyme 0.0072 0.0263 0.0455
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0109 0.0499 0.1638
Schistosoma mansoni diacylglycerol kinase theta 0.0041 0.0061 0.0205
Trichomonas vaginalis CMGC family protein kinase 0.0076 0.0286 0.0905
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0379 0.2228 0.7775
Schistosoma mansoni serine/threonine protein kinase 0.0227 0.1251 0.4545
Brugia malayi Tyrosine-protein kinase abl-1 0.0046 0.0091 0.0151
Entamoeba histolytica protein kinase, putative 0.0063 0.0203 0.1282
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.018 0.0562
Schistosoma mansoni diacylglycerol kinase theta 0.0041 0.0061 0.0205
Echinococcus granulosus calcium activated potassium channel 0.0086 0.035 0.111
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0121 0.0574 0.054
Echinococcus multilocularis tyrosine protein kinase Blk 0.0084 0.034 0.0306
Schistosoma mansoni rac gtpase activating protein 0.0041 0.0061 0.0205
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0093 0.0393 0.5293
Loa Loa (eye worm) hypothetical protein 0.005 0.0123 0.0211
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0041 0.0061 0.0102
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0093 0.0393 0.5293
Echinococcus granulosus dna polymerase kappa 0.0038 0.0041 0.0014
Loa Loa (eye worm) hypothetical protein 0.0042 0.0069 0.0116
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0109 0.0499 0.0466
Toxoplasma gondii CMGC kinase, CK2 family 0.0092 0.0388 0.1087
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0353 0.2057 0.2029
Schistosoma mansoni pyruvate kinase 0.0072 0.0263 0.094
Echinococcus granulosus serine/threonine protein kinase 0.0153 0.078 0.2637
Trichomonas vaginalis AGC family protein kinase 0.0144 0.0725 0.233
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0093 0.0393 0.5293
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0168 0.0291
Echinococcus granulosus tyrosine protein kinase Fyn 0.0102 0.0455 0.1482
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0442 0.1591
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.1096 0.3979
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0041 0.0228
Entamoeba histolytica hypothetical protein 0.0114 0.0527 0.3397
Schistosoma mansoni hypothetical protein 0.0104 0.0467 0.1683
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0084 0.034 0.0306
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.019 0.1018 0.1794
Trypanosoma cruzi Protein kinase B 0.0153 0.078 0.5351
Giardia lamblia Kinase, CMGC CLK 0.0144 0.0723 0.4843
Echinococcus granulosus insulin receptor 0.0144 0.0723 0.2433
Entamoeba histolytica hypothetical protein 0.0041 0.0061 0.0359
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0042 0.0069 0.0034
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.015 0.0757 0.5191
Trypanosoma cruzi cdc2-related kinase 1 0.011 0.0505 0.3446
Echinococcus multilocularis Diacylglycerol kinase theta 0.0041 0.0061 0.0027
Schistosoma mansoni tyrosine kinase 0.0074 0.0274 0.098
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0144 0.0723 0.468
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0065 0.0218 0.0184
Plasmodium vivax protein kinase Crk2 0.011 0.0505 0.6809
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0393 0.1253
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0065 0.0218 0.1383
Loa Loa (eye worm) hypothetical protein 0.014 0.0694 0.1221
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0258 0.1453 0.5023
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0098 0.0216
Leishmania major protein kinase, putative 0.0093 0.0393 0.2669
Echinococcus granulosus titin 0.0039 0.005 0.0045
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0074 0.0273 0.1846
Loa Loa (eye worm) hypothetical protein 0.0087 0.0358 0.0628
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0481 0.8549
Echinococcus multilocularis tyrosine protein kinase Abl 0.0046 0.0091 0.0056
Brugia malayi PAN domain containing protein 0.0037 0.0039 0.0059
Brugia malayi Protein kinase domain 0.0078 0.03 0.052
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0098 0.1245
Echinococcus multilocularis Immunoglobulin 0.0047 0.0102 0.0067
Leishmania major DNA polymerase eta, putative 0.0037 0.0034 0.0192
Echinococcus granulosus serine:threonine kinase SAD 1 0.0059 0.018 0.0505
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0039 0.005 0.0082
Onchocerca volvulus 0.0037 0.0039 0.0108
Brugia malayi Protein kinase domain containing protein 0.0339 0.1968 0.3472
Echinococcus multilocularis mitogen activated protein kinase 14 0.015 0.0757 0.0725
Plasmodium vivax serine/threonine-protein kinase NEK4, putative 0.0044 0.0079 0.1064

Activities

Activity type Activity value Assay description Source Reference
Cured (functional) = 0 % Antimalarial activity was evaluated against Plasmodium vinckei vinckei (strain V52) after ip administration at dose 10 mg/kg ChEMBL. 2061923
Cured (functional) = 0 % Antimalarial activity was evaluated against Plasmodium vinckei vinckei (strain V52) after ip administration at dose 15 mg/kg ChEMBL. 2061923
Cured (functional) = 0 % Antimalarial activity was evaluated against Plasmodium vinckei vinckei (strain V52) after ip administration at dose 20 mg/kg ChEMBL. 2061923
Cured (functional) = 0 % Antimalarial activity was evaluated against Plasmodium vinckei vinckei (strain V52) after ip administration at dose 25 mg/kg ChEMBL. 2061923
Cured (functional) = 0 % Antimalarial activity was evaluated against Plasmodium vinckei vinckei (strain V52) after ip administration at dose 30 mg/kg ChEMBL. 2061923
Cured (functional) = 0 % Antimalarial activity was evaluated against Plasmodium vinckei vinckei (strain V52) after ip administration at dose 50 mg/kg ChEMBL. 2061923
Cured (functional) = 0 % Antimalarial activity was evaluated against Plasmodium vinckei vinckei (strain V52) after ip administration at dose 70 mg/kg ChEMBL. 2061923
Cured (functional) = 0 % Antimalarial activity was evaluated against Plasmodium vinckei vinckei (strain V52) after ip administration at dose 15 mg/kg ChEMBL. 2061923
Cured (functional) = 0 % Antimalarial activity was evaluated against Plasmodium vinckei vinckei (strain V52) after ip administration at dose 25 mg/kg ChEMBL. 2061923
Cured (functional) = 0 % Antimalarial activity was evaluated against Plasmodium vinckei vinckei (strain V52) after ip administration at dose 50 mg/kg ChEMBL. 2061923
Cured (functional) = 0 % Antimalarial activity was evaluated against Plasmodium vinckei vinckei (strain V52) after ip administration at dose 70 mg/kg ChEMBL. 2061923
GI50 (functional) -5.818 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.626 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.134 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.119 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.976 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.97 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.903 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.852 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
Mean survival days (functional) = 0 day Increase in mean survival days was determined in mice after ip administration of 10 mg/kg ChEMBL. 2061923
Mean survival days (functional) = 0 day Increase in mean survival days was determined in mice after ip administration of 15 mg/kg ChEMBL. 2061923
Mean survival days (functional) = 0 day Increase in mean survival days was determined in mice after ip administration of 20 mg/kg ChEMBL. 2061923
Mean survival days (functional) = 0 day Increase in mean survival days was determined in mice after ip administration of 30 mg/kg ChEMBL. 2061923
Mean survival days (functional) = 0 day Increase in mean survival days was determined in mice after ip administration of 50 mg/kg ChEMBL. 2061923
Mean survival days (functional) = 0 day Increase in mean survival days was determined in mice after ip administration of 10 mg/kg ChEMBL. 2061923
Mean survival days (functional) = 0 day Increase in mean survival days was determined in mice after ip administration of 15 mg/kg ChEMBL. 2061923
Mean survival days (functional) = 0 day Increase in mean survival days was determined in mice after ip administration of 20 mg/kg ChEMBL. 2061923
Mean survival days (functional) = 0 day Increase in mean survival days was determined in mice after ip administration of 30 mg/kg ChEMBL. 2061923
Mean survival days (functional) = 0 day Increase in mean survival days was determined in mice after ip administration of 50 mg/kg ChEMBL. 2061923
Mean survival days (functional) = 0.1 day Increase in mean survival days was determined in mice after ip administration of 25 mg/kg ChEMBL. 2061923
Mean survival days (functional) = 0.1 day Increase in mean survival days was determined in mice after ip administration of 25 mg/kg ChEMBL. 2061923
Mean survival days (functional) = 0.5 day Increase in mean survival days of Plasmodium innoculated mice following 70 mg/Kg i.p. administration. ChEMBL. 2061923

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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