Detailed information for compound 1207741

Basic information

Technical information
  • TDR Targets ID: 1207741
  • Name: N-[2-(4-chlorophenyl)ethyl]-3-[3-(4-ethylphen yl)-6-oxo-4,5-dihydropyridazin-1-yl]propanami de
  • MW: 411.924 | Formula: C23H26ClN3O2
  • H donors: 1 H acceptors: 2 LogP: 3.74 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)C1=NN(C(=O)CC1)CCC(=O)NCCc1ccc(cc1)Cl
  • InChi: 1S/C23H26ClN3O2/c1-2-17-3-7-19(8-4-17)21-11-12-23(29)27(26-21)16-14-22(28)25-15-13-18-5-9-20(24)10-6-18/h3-10H,2,11-16H2,1H3,(H,25,28)
  • InChiKey: KPWYVPHYTQWINQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-chlorophenyl)ethyl]-3-[3-(4-ethylphenyl)-6-keto-4,5-dihydropyridazin-1-yl]propionamide
  • K788-6651
  • NCGC00140374-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.018 0.0205
Plasmodium falciparum plasmepsin III 0.0054 0.0151 0.0443
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0046 0.0122 0.0142
Echinococcus multilocularis musashi 0.0044 0.0114 0.0111
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0092 0.0089
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0311 0.1125 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0016 0.0007 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0234 0.0559
Schistosoma mansoni smad 0.0016 0.0007 0.0009
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0027 0.0075
Brugia malayi hypothetical protein 0.0369 0.1346 0.3709
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0046 0.0122 0.1082
Plasmodium falciparum plasmepsin X 0.0054 0.0151 0.0443
Loa Loa (eye worm) glutaminase 2 0.0273 0.098 0.2701
Onchocerca volvulus Huntingtin homolog 0.0082 0.0257 0.0614
Toxoplasma gondii target of rapamycin (TOR), putative 0.0041 0.0102 0.0303
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0054 0.2062
Brugia malayi CXXC zinc finger family protein 0.0058 0.0168 0.0463
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0016 0.008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0168 0.0464
Brugia malayi steroid hormone receptor 0.0021 0.0027 0.0075
Onchocerca volvulus RING finger protein 141 homolog 0.0016 0.0007 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0027 0.0075
Mycobacterium ulcerans lipase LipD 0.0046 0.0122 0.1108
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0075 0.0232 0.0639
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0017 0.009
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0056 0.0161 0.0443
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0055 0.0156 0.1332
Onchocerca volvulus Huntingtin homolog 0.0082 0.0257 0.0614
Brugia malayi YY1-associated factor 2 0.0311 0.1125 0.3101
Brugia malayi Zinc finger, C2H2 type family protein 0.0016 0.0007 0.0018
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0016 0.001
Brugia malayi hypothetical protein 0.0054 0.0151 0.0415
Schistosoma mansoni hypothetical protein 0.0311 0.1125 0.1309
Echinococcus multilocularis zinc finger protein Ran binding 0.0311 0.1125 0.1122
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0134 0.0455 0.0525
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0041
Echinococcus multilocularis lysosomal alpha glucosidase 0.0342 0.1241 0.1238
Plasmodium vivax hypothetical protein, conserved 0.0874 0.3259 1
Brugia malayi N-terminal motif family protein 0.0308 0.1113 0.3068
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0057 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0072 0.0166
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0038 0.0239
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0305 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0054 0.0151 0.0416
Plasmodium vivax aspartyl proteinase, putative 0.0054 0.0151 0.0443
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0015 0.0003 0.0004
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.008 0.0077
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0098 0.0269
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0016 0.0007 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0038 0.0289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0125 0.0296
Loa Loa (eye worm) DIX domain-containing protein 0.0015 0.0003 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0011 0.0036
Brugia malayi Cytochrome P450 family protein 0.0018 0.0016 0.0043
Brugia malayi MH1 domain containing protein 0.0016 0.0007 0.002
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0016 0.0007 0.0009
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0007 0.0004
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0311 0.1125 0.1122
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0104 0.0871
Schistosoma mansoni dishevelled 0.0015 0.0003 0.0004
Echinococcus granulosus neuropeptide receptor A26 0.0288 0.1037 0.1203
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0055 0.0156 0.6531
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0038 0.0279
Brugia malayi Smad1 0.0016 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0308 0.1113 0.3069
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0874 0.3259 1
Loa Loa (eye worm) hypothetical protein 0.0245 0.0877 0.2417
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0015 0.0025
Brugia malayi Eukaryotic aspartyl protease family protein 0.0054 0.0151 0.0415
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0027 0.0075
Brugia malayi intermediate filament protein 0.0044 0.0114 0.0313
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0016 0.001
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0007 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0186 0.0217
Plasmodium falciparum plasmepsin II 0.0054 0.0151 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0113 0.0266
Brugia malayi hypothetical protein 0.0025 0.0043 0.0119
Trypanosoma cruzi WLM domain containing protein, putative 0.0311 0.1125 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0027 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0055 0.0156 0.0152
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0075
Echinococcus multilocularis smad 0.0016 0.0007 0.0004
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0104 0.03
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0151 0.0175
Plasmodium vivax plasmepsin V, putative 0.0054 0.0151 0.0443
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0005
Onchocerca volvulus 0.0075 0.0232 0.0553
Brugia malayi beta-lactamase family protein 0.0046 0.0122 0.0335
Onchocerca volvulus 0.0311 0.1125 0.2714
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0027 0.0075
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0057 0.0164
Echinococcus granulosus Zinc finger RanBP2 type 0.0311 0.1125 0.1306
Onchocerca volvulus 0.0054 0.0151 0.0357
Brugia malayi Cytochrome P450 family protein 0.0046 0.012 0.0331
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0027 0.0032
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0016 0.0007 0.0004
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0038 0.0289
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0016 0.008
Onchocerca volvulus 0.0311 0.1125 0.2714
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0027 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Trichomonas vaginalis esterase, putative 0.0046 0.0122 0.0288
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0217 0.0769 0.0891
Echinococcus granulosus neuropeptide s receptor 0.0288 0.1037 0.1203
Echinococcus multilocularis lamin 0.0044 0.0114 0.0111
Schistosoma mansoni dishevelled 0.0015 0.0003 0.0004
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0046 0.012 0.1095
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0104 0.0287
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0016 0.001
Plasmodium vivax aspartyl proteinase, putative 0.0054 0.0151 0.0443
Trichomonas vaginalis importin beta-1, putative 0.0046 0.012 0.0284
Toxoplasma gondii aspartyl protease 0.0054 0.0151 0.0453
Schistosoma mansoni mind bomb 0.0016 0.0007 0.0008
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0055 0.0156 0.1332
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0104
Schistosoma mansoni cathepsin D (A01 family) 0.0054 0.0151 0.0175
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Plasmodium falciparum plasmepsin VII 0.0054 0.0151 0.0443
Entamoeba histolytica hypothetical protein 0.0076 0.0235 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.005 0.0136 0.0374
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0874 0.3259 0.379
Brugia malayi hypothetical protein 0.0067 0.0202 0.0557
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0027 0.0028
Schistosoma mansoni hypothetical protein 0.0018 0.0016 0.0018
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0143
Brugia malayi MH1 domain containing protein 0.0016 0.0007 0.002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0151 0.0175
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0186 0.0513
Echinococcus granulosus tar DNA binding protein 0.0063 0.0186 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0072 0.0166
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0122 0.0354
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0035 0.0036
Schistosoma mansoni survival motor neuron protein 0.0075 0.0232 0.027
Schistosoma mansoni ran 0.0042 0.0104 0.0121
Loa Loa (eye worm) hypothetical protein 0.0054 0.0151 0.0416
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0016 0.0007 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.007 0.0195
Onchocerca volvulus 0.0329 0.1193 0.2879
Brugia malayi latrophilin 2 splice variant baaae 0.0469 0.1723 0.475
Echinococcus granulosus neutral alpha glucosidase AB 0.0076 0.0234 0.0269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0027 0.0075
Brugia malayi Glycosyl hydrolases family 31 protein 0.0342 0.1241 0.3421
Echinococcus granulosus beta LACTamase domain containing family member 0.0046 0.0122 0.0138
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0016 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0234 0.2033
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0098 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0336
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0874 0.3259 1
Brugia malayi B-box zinc finger family protein 0.0016 0.0007 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0186 0.0217
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Echinococcus multilocularis lysosomal alpha glucosidase 0.0342 0.1241 0.1238
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0024 0.0036 0.01
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0075
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0151 0.0175
Brugia malayi hypothetical protein 0.0016 0.0007 0.0018
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.007 0.0195
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0016 0.0007 0.0009
Brugia malayi Cytochrome P450 family protein 0.0046 0.012 0.0331
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0057 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0874 0.3259 0.7879
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0007 0.0019
Schistosoma mansoni intermediate filament proteins 0.0044 0.0114 0.0133
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0038 0.0279
Brugia malayi Bromodomain containing protein 0.0054 0.0153 0.0422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0016 0.008
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0027 0.0024
Schistosoma mansoni coup transcription factor 0.0021 0.0027 0.0032
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.018 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0156 0.037
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0038 0.0766
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0016 0.0007 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0011 0.0036
Brugia malayi RNA, U transporter 1 0.016 0.0555 0.1529
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0011 0.0036
Brugia malayi MH2 domain containing protein 0.0236 0.0839 0.2313
Trichomonas vaginalis glutaminase, putative 0.0273 0.098 0.2364
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Schistosoma mansoni hypothetical protein 0.0217 0.0769 0.0895
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0142
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0016 0.0081
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Loa Loa (eye worm) hypothetical protein 0.0329 0.1193 0.3288
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0311 0.1125 0.3101
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0007 0.0008
Echinococcus multilocularis zinc finger protein 0.0017 0.001 0.0007
Brugia malayi hypothetical protein 0.0015 0.0003 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0046 0.0122 0.0288
Loa Loa (eye worm) hypothetical protein 0.0803 0.2991 0.8244
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0016 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0082 0.0193
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0016 0.008
Echinococcus granulosus peregrin 0.0031 0.0063 0.0069
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0336
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0016 0.008
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0054 0.0123
Entamoeba histolytica hypothetical protein 0.0076 0.0235 1
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0311 0.1125 0.3438
Loa Loa (eye worm) hypothetical protein 0.0082 0.0257 0.0708
Onchocerca volvulus 0.0874 0.3259 0.7879
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0043 0.0113
Trypanosoma cruzi cytochrome P450, putative 0.0046 0.012 0.1018
Mycobacterium tuberculosis Probable lipase LipE 0.0046 0.0122 0.1082
Loa Loa (eye worm) hypothetical protein 0.0054 0.0151 0.0416
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0103 0.012
Echinococcus granulosus zinc finger protein 0.0017 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0076
Echinococcus multilocularis ring finger protein 170 0.0016 0.0007 0.0003
Trypanosoma brucei glucosidase, putative 0.0076 0.0234 0.2033
Leishmania major GTP-binding protein, putative 0.0042 0.0104 0.0871
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0075
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0084 0.0198
Loa Loa (eye worm) hypothetical protein 0.0094 0.0305 0.084
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0113 0.0266
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0007 0.0005
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.018 0.1707
Giardia lamblia GTOR 0.0055 0.0156 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0217 0.0769 0.0766
Echinococcus multilocularis SWI:SNF matrix associated 0.0874 0.3259 0.3257
Trypanosoma brucei hypothetical protein, conserved 0.0311 0.1125 1
Onchocerca volvulus 0.0311 0.1125 0.2714
Plasmodium falciparum phd finger protein, putative 0.0029 0.0057 0.0154
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0041
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0033 0.024
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0055 0.0156 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.007 0.0163
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0016 0.0081
Schistosoma mansoni hypothetical protein 0.0217 0.0769 0.0895
Leishmania major hypothetical protein, conserved 0.0311 0.1125 1
Brugia malayi Probable ClpP-like protease 0.0094 0.0305 0.0839
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0038 0.0239
Echinococcus granulosus voltage gated potassium channel 0.0016 0.0007 0.0004
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0181 0.1646
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.018 0.1546
Chlamydia trachomatis DNA topoisomerase I 0.0874 0.3259 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0874 0.3259 0.3257
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0059 0.0137
Echinococcus multilocularis 0.0016 0.0007 0.0003
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0054 0.0151 0.0172
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0336
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0038 0.0104
Schistosoma mansoni zinc finger protein 0.0311 0.1125 0.1309
Echinococcus multilocularis GPCR, family 2 0.0217 0.0769 0.0766
Echinococcus granulosus RING finger protein 185 0.0016 0.0007 0.0004
Echinococcus multilocularis snurportin 1 0.0602 0.223 0.2228
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0104 0.0871
Trypanosoma cruzi cytochrome P450, putative 0.0046 0.012 0.1018
Brugia malayi TAR-binding protein 0.0063 0.0186 0.0512
Mycobacterium ulcerans glutaminase 0.0273 0.098 1
Echinococcus granulosus GPCR family 2 0.0217 0.0769 0.0891
Schistosoma mansoni cpg binding protein 0.0058 0.0168 0.0196
Echinococcus granulosus fetal alzheimer antigen falz 0.0019 0.0018 0.0017
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0103 0.012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0027 0.0024
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0003 0.0004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0217 0.0769 0.212
Trypanosoma cruzi target of rapamycin kinase 3 0.0044 0.0113 0.0951
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0007 0.0012
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0055 0.0156 0.0177
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0015 0.0003 0.0009
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0305 0.0893
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0041
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0234 0.0559
Toxoplasma gondii aspartyl protease ASP1 0.0054 0.0151 0.0453
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0027 0.0032
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0305 0.5
Echinococcus multilocularis survival motor neuron protein 1 0.0369 0.1346 0.1343
Trypanosoma cruzi hypothetical protein, conserved 0.0311 0.1125 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0235 0.0269
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0165 0.0571 0.0665
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Giardia lamblia Ser/Thr protein kinase 0.0016 0.0007 0.0000014825
Brugia malayi cytoplasmic intermediate filament protein 0.0024 0.0036 0.0099
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0027 0.0028
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0016 0.001
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.0075 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Schistosoma mansoni brg-1 associated factor 0.0874 0.3259 0.3793
Brugia malayi hypothetical protein 0.0016 0.0007 0.0018
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0007 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.007 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0165 0.0571 0.0665
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0016 0.0007 0.0003
Echinococcus granulosus ring finger protein 113a 0.0016 0.0007 0.0005
Mycobacterium tuberculosis Probable esterase LipL 0.0046 0.0122 0.1082
Schistosoma mansoni hypothetical protein 0.0029 0.0057 0.0066
Loa Loa (eye worm) CYP4Cod1 0.0046 0.012 0.0332
Echinococcus granulosus SWI:SNF matrix associated 0.0874 0.3259 0.379
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0874 0.3259 0.8984
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0016 0.0007 0.0009
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0234 0.0559
Echinococcus multilocularis 0.0018 0.0016 0.0012
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0055 0.0156 0.6531
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.012 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0102 0.024
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0016 0.008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0436 0.0507
Entamoeba histolytica hypothetical protein 0.0046 0.012 0.4975
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Brugia malayi PHD-finger family protein 0.002 0.0024 0.0065
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0043 0.0113
Echinococcus granulosus histone lysine methyltransferase setb 0.0152 0.0523 0.0605
Loa Loa (eye worm) brahma associated protein 0.0874 0.3259 0.8984
Echinococcus multilocularis neuropeptide s receptor 0.0288 0.1037 0.1034
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0016 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0234 0.0559
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0044 0.0114 0.0314
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Toxoplasma gondii aspartyl protease ASP3 0.0054 0.0151 0.0453
Trichomonas vaginalis D-aminoacylase, putative 0.0046 0.0122 0.0288
Loa Loa (eye worm) hypothetical protein 0.0311 0.1125 0.3101
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0308 0.0304
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0104
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0235 0.0232
Loa Loa (eye worm) hypothetical protein 0.0067 0.0202 0.0558
Schistosoma mansoni hypothetical protein 0.0217 0.0769 0.0895
Onchocerca volvulus 0.0046 0.0122 0.0287
Loa Loa (eye worm) hypothetical protein 0.0067 0.0202 0.0558
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0186 0.0183
Toxoplasma gondii hypothetical protein 0.0016 0.0007 0.001
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0054 0.0151 0.0453
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0152 0.0523 0.052
Schistosoma mansoni Smad4 0.0016 0.0007 0.0009
Trichomonas vaginalis ankyrin, putative 0.0016 0.0007 0.0009
Schistosoma mansoni cytochrome P450 0.0018 0.0016 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0075
Loa Loa (eye worm) cytochrome P450 0.0018 0.0016 0.0043
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0016 0.0007 0.0004
Leishmania major cytochrome p450-like protein 0.0046 0.012 0.1018
Schistosoma mansoni hypothetical protein 0.0602 0.223 0.2595
Brugia malayi Bromodomain containing protein 0.0026 0.0046 0.0125
Onchocerca volvulus 0.0016 0.0007 0.0008
Plasmodium falciparum plasmepsin IX 0.0054 0.0151 0.0443
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0104 0.0286
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0027 0.0032
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0334 0.1214 0.1211
Loa Loa (eye worm) hypothetical protein 0.0311 0.1125 0.3101
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0043 0.0328
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0017 0.0013
Schistosoma mansoni bromodomain containing protein 0.0046 0.0123 0.0143
Echinococcus multilocularis lamin dm0 0.0044 0.0114 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0113 0.0266
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0174 0.048
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0017 0.009
Loa Loa (eye worm) hypothetical protein 0.0469 0.1723 0.475
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0027 0.0028
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0308 0.1113 0.2686
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Brugia malayi aspartic protease BmAsp-1, identical 0.0054 0.0151 0.0415
Giardia lamblia Kinase, NEK 0.0016 0.0007 0.0000014825
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0308 0.0354
Brugia malayi MH2 domain containing protein 0.0016 0.0007 0.002
Toxoplasma gondii HEAT repeat-containing protein 0.0056 0.0161 0.0483
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0046 0.0122 0.1108
Plasmodium falciparum plasmepsin VI 0.0054 0.0151 0.0443
Trypanosoma brucei hypothetical protein, conserved 0.0311 0.1125 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.007 0.1879
Schistosoma mansoni ran 0.0042 0.0104 0.0121
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0122 0.1029
Trypanosoma cruzi WLM domain containing protein, putative 0.0311 0.1125 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0084 0.0198
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.0032 0.007 0.0192
Echinococcus multilocularis SWI:SNF matrix associated 0.0874 0.3259 0.3257
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.014 0.0479 0.0476
Trichomonas vaginalis ran, putative 0.0042 0.0104 0.0245
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0057 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0021 0.0027 0.0028
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0054 0.0123
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0007 0.0004
Plasmodium falciparum plasmepsin V 0.0054 0.0151 0.0443
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0054 0.0151 0.0453
Trichomonas vaginalis sucrase-isomaltase, putative 0.0076 0.0234 0.0559
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0016 0.0007 0.0004
Schistosoma mansoni importin beta-1 0.0056 0.0161 0.0187
Echinococcus granulosus microtubule associated protein 2 0.2281 0.8593 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0067
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0342 0.1241 0.3422
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0054 0.0123
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0016 0.008
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0295 0.1065 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0044 0.0114 0.0314
Schistosoma mansoni dep domain containing protein 0.0015 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0054 0.0148
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0021 0.0021
Schistosoma mansoni lamin 0.0044 0.0114 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0072 0.0166
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0336
Loa Loa (eye worm) histone methyltransferase 0.0023 0.0035 0.0095
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0017 0.0046
Leishmania major hypothetical protein, conserved 0.0311 0.1125 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0059 0.0137
Toxoplasma gondii helicase, putative 0.0016 0.0007 0.001
Brugia malayi DIX domain containing protein 0.0015 0.0003 0.0008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0686 0.2546 0.7017
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0311 0.1125 0.3101
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0165 0.0571 0.1574
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0025 0.004 0.0036
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0007 0.0004
Echinococcus multilocularis dnaJ subfamily B 0.0528 0.1947 0.1945
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0043 0.0123
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0874 0.3259 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0104 0.0117
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0016 0.0007 0.0003
Leishmania major hypothetical protein, conserved 0.0025 0.0043 0.0328
Loa Loa (eye worm) intermediate filament protein 0.0044 0.0114 0.0314
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0016 0.008
Schistosoma mansoni smad1 5 8 and 0.0016 0.0007 0.0009
Chlamydia trachomatis SWIB complex protein 0.0874 0.3259 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0017 0.0019
Loa Loa (eye worm) hypothetical protein 0.0048 0.0129 0.0357
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0076 0.0234 0.0559
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0027 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0054 0.0151 0.0358
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0054 0.0123
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0027 0.0058
Brugia malayi brahma associated protein 60 kDa 0.0874 0.3259 0.8984
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0009
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0027 0.0058
Echinococcus multilocularis mixed lineage leukemia protein mll 0.002 0.0021 0.0018
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0151 0.0175
Onchocerca volvulus 0.0292 0.1052 0.2538
Echinococcus multilocularis cpg binding protein 0.0063 0.0186 0.0183
Echinococcus multilocularis microtubule associated protein 2 0.2281 0.8593 0.8593
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0305 0.0355
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0311 0.1125 0.1306
Leishmania major hypothetical protein, conserved 0.0311 0.1125 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0016 0.0081
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0311 0.1125 0.1122
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0059 0.0137
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0007 0.0004
Schistosoma mansoni alpha-glucosidase 0.0294 0.1061 0.1235
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0016 0.008
Schistosoma mansoni alpha-glucosidase 0.0294 0.1061 0.1235
Echinococcus multilocularis beta LACTamase domain containing family member 0.0046 0.0122 0.0118
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0151 0.0175
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0311 0.1125 1
Plasmodium vivax importin-beta 2, putative 0.0056 0.0161 0.0473
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0054 0.0123
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0027 0.0032
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0305 0.0351
Brugia malayi Bromodomain containing protein 0.0031 0.0063 0.0173
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0027 0.0032
Loa Loa (eye worm) RNA binding protein 0.0063 0.0186 0.0513
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0016 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0217 0.0769 0.2119
Brugia malayi hypothetical protein 0.0054 0.0151 0.0415
Brugia malayi MH2 domain containing protein 0.0016 0.0007 0.002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0038 0.0766
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0054 0.0147
Onchocerca volvulus 0.0016 0.0007 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0311 0.1125 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0186 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0027 0.0032
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0017 0.009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0971 0.3628 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0046 0.0122 0.1082
Loa Loa (eye worm) hypothetical protein 0.0217 0.0769 0.212
Echinococcus multilocularis peregrin 0.0031 0.0063 0.006
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0016 0.001
Trichomonas vaginalis set domain proteins, putative 0.1105 0.4136 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0046 0.0126
Echinococcus multilocularis muscleblind protein 0.0245 0.0877 0.0874
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0151 0.0175
Loa Loa (eye worm) phosphatidylinositol 3 0.0055 0.0156 0.0429
Brugia malayi isocitrate dehydrogenase 0.0016 0.0007 0.0019
Loa Loa (eye worm) hypothetical protein 0.0054 0.0151 0.0416
Brugia malayi Latrophilin receptor protein 2 0.0217 0.0769 0.2119
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0234 0.2033
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0015 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Brugia malayi glutaminase DH11.1 0.0273 0.098 0.27
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0098 0.0114
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0088 0.0242
Toxoplasma gondii hypothetical protein 0.0016 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0075
Onchocerca volvulus Alhambra homolog 0.0029 0.0057 0.013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0027 0.0075
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0007 0.0008
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0311 0.1125 0.3101
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0235 0.0273
Onchocerca volvulus 0.0024 0.0038 0.0084
Mycobacterium leprae Probable lipase LipE 0.0046 0.0122 0.3668
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0602 0.223 0.6147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0087 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0034
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0311 0.1125 1
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0027 0.0075
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.018 0.1707
Loa Loa (eye worm) RING finger protein 20 0.0016 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0245 0.0877 0.2417
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0043 0.0328
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0015 0.0003 0.0008
Onchocerca volvulus 0.0016 0.0007 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0027 0.0075
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0016 0.0007 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0113 0.0266
Leishmania major hypothetical protein, conserved 0.0311 0.1125 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0027 0.0075
Onchocerca volvulus 0.0054 0.0151 0.0357
Echinococcus granulosus ring finger protein 170 0.0016 0.0007 0.0004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.018 0.1629
Echinococcus multilocularis ring and YY1 binding protein 0.0311 0.1125 0.1122
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0181 0.5731
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Leishmania major cytochrome p450-like protein 0.0018 0.0016 0.0081
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0046 0.0122 0.0336
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0016 0.0007 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0186 0.0217
Echinococcus granulosus ring and YY1 binding protein 0.0311 0.1125 0.1306
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.012 0.0284
Toxoplasma gondii RING zinc finger protein 0.0016 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0311 0.1125 0.3101
Schistosoma mansoni hypothetical protein 0.0436 0.1601 0.1863
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0016 0.001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0092 0.0104
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0055 0.0156 0.1332
Schistosoma mansoni hypothetical protein 0.0528 0.1947 0.2266
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0007 0.0002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0035 0.0031
Schistosoma mansoni alpha glucosidase 0.0076 0.0234 0.0272
Trichomonas vaginalis ankyrin, putative 0.0016 0.0007 0.0009
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0043 0.0111 0.0306
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0311 0.1125 1
Echinococcus multilocularis importin subunit beta 1 0.0056 0.0161 0.0157
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0038 0.1369
Schistosoma mansoni hypothetical protein 0.0436 0.1601 0.1863
Echinococcus granulosus jumonji domain containing protein 0.004 0.01 0.0113
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0067
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0311 0.1125 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0151 0.0175
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0027 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0038 0.0239
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0027 0.0028
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0305 0.3004
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0043 0.0328
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0038 0.0239
Echinococcus multilocularis muscleblind protein 1 0.0245 0.0877 0.0874
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0027 0.0075
Plasmodium falciparum plasmepsin I 0.0054 0.0151 0.0443
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0027 0.0028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0027 0.0028
Loa Loa (eye worm) Smad1 0.0016 0.0007 0.0021
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.018 0.0541
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0016 0.001
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0016 0.0007 0.0011
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0874 0.3259 0.3257
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0007 0.0021
Onchocerca volvulus 0.0016 0.0007 0.0008
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0186 0.0217
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0016 0.008
Schistosoma mansoni hypothetical protein 0.0874 0.3259 0.3793
Schistosoma mansoni cathepsin D (A01 family) 0.0054 0.0151 0.0175
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0016 0.001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0027 0.0028
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0008
Toxoplasma gondii ABC1 family protein 0.0046 0.0122 0.0364
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0016 0.008
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0008
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0054 0.0421
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0027 0.0075
Schistosoma mansoni glutaminase 0.0273 0.098 0.114
Loa Loa (eye worm) hypothetical protein 0.0292 0.1052 0.29
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0102 0.024
Onchocerca volvulus 0.0046 0.0122 0.0287
Schistosoma mansoni cellular tumor antigen P53 0.0329 0.1193 0.1388
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0305 0.0916
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0054 0.0123
Onchocerca volvulus 0.0021 0.0027 0.0058
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0104 0.6542
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0874 0.3259 1
Onchocerca volvulus Putative RING finger protein 207 0.0016 0.0007 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0059 0.0137
Echinococcus granulosus zinc finger protein Ran binding 0.0311 0.1125 0.1306
Brugia malayi Importin beta-1 subunit 0.0056 0.0161 0.0442
Brugia malayi Intermediate filament tail domain containing protein 0.0044 0.0114 0.0313
Toxoplasma gondii hypothetical protein 0.0016 0.0007 0.001
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0017 0.009
Brugia malayi hypothetical protein 0.0292 0.1052 0.29
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0181 0.1646
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0011 0.0036
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.0016 0.0007 0.001
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0016 0.001
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0233 0.0272
Schistosoma mansoni smad1 5 8 and 0.0016 0.0007 0.0009
Echinococcus granulosus muscleblind protein 0.0245 0.0877 0.1017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0027 0.0075
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0016 0.008
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0076 0.0234 0.0645
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.012 0.1015
Echinococcus granulosus lysosomal alpha glucosidase 0.0342 0.1241 0.1441
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Brugia malayi brahma associated protein 60 kDa 0.0874 0.3259 0.8984
Echinococcus multilocularis tumor protein p63 0.2246 0.8462 0.8461
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0016 0.001
Echinococcus granulosus survival motor neuron protein 1 0.0369 0.1346 0.1563
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0104 0.0101
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0017 0.0016
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0046 0.0122 0.1082
Entamoeba histolytica hypothetical protein 0.0076 0.0235 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0076 0.0234 0.0644
Plasmodium falciparum plasmepsin IV 0.0054 0.0151 0.0443
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0027 0.0075
Brugia malayi Cytochrome P450 family protein 0.0037 0.0088 0.0241
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0016 0.0038
Mycobacterium tuberculosis Probable hydrolase 0.0046 0.0122 0.1082
Loa Loa (eye worm) aspartyl protease 6 0.0054 0.0151 0.0416
Schistosoma mansoni z-protein (S1r protein) 0.0015 0.0003 0.0004
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0043 0.0113
Echinococcus multilocularis geminin 0.0436 0.1601 0.1598
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0098 0.0114
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0092 0.0255
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0076 0.0234 0.9966
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.014 0.0479 0.0557
Mycobacterium tuberculosis Conserved protein 0.0046 0.0122 0.1082
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0311 0.1125 0.3445
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0027 0.0075
Schistosoma mansoni memapsin-2 (A01 family) 0.1341 0.503 0.5853
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0038 0.1369
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0016 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0027 0.0075
Leishmania major hypothetical protein, conserved 0.0046 0.0122 0.1029
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0046 0.0122 0.0335
Echinococcus granulosus intermediate filament protein 0.0044 0.0114 0.0129
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0019 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0054 0.0123
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.012 0.0332
Onchocerca volvulus 0.0044 0.0114 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0027 0.0075
Echinococcus granulosus lamin dm0 0.0044 0.0114 0.0129
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0076 0.0234 0.9966
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0336
Echinococcus multilocularis neutral alpha glucosidase AB 0.0076 0.0234 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0016 0.001
Schistosoma mansoni hypothetical protein 0.0075 0.0232 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0102 0.024
Brugia malayi jmjC domain containing protein 0.0095 0.0308 0.0847
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0104 0.031
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0055 0.0156 0.1332
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0046 0.0122 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0113 0.0266
Brugia malayi cytochrome P450 0.0018 0.0016 0.0043
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0092 0.0254
Schistosoma mansoni peter pan-related 0.0016 0.0007 0.0008
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0016 0.0007 0.0018
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0016 0.008
Brugia malayi hypothetical protein 0.0016 0.0007 0.0018
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.012 0.0332
Toxoplasma gondii ran binding protein 0.0311 0.1125 0.3445
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0017 0.009
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0016 0.008
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0016 0.0007 0.0004
Brugia malayi RING finger protein 20 0.0016 0.0007 0.0018
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0054 0.0151 0.0148
Echinococcus granulosus tumor protein p63 0.2246 0.8462 0.9847
Brugia malayi ecdysteroid receptor 0.0021 0.0027 0.0075
Echinococcus granulosus smad 0.0016 0.0007 0.0005
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0016 0.0007 0.0003
Schistosoma mansoni cpg binding protein 0.0063 0.0186 0.0216
Plasmodium vivax aspartyl protease, putative 0.0054 0.0151 0.0443
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0016 0.0007 0.001
Brugia malayi hypothetical protein 0.0082 0.0257 0.0708
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0311 0.1125 1
Onchocerca volvulus 0.0016 0.0007 0.0008
Onchocerca volvulus 0.014 0.0479 0.1151
Leishmania major hypothetical protein, conserved 0.0311 0.1125 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0104 0.0871
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Brugia malayi PHD-finger family protein 0.0029 0.0057 0.0156
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0054 0.0151 0.0416
Loa Loa (eye worm) glutaminase 0.0273 0.098 0.2701
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0016 0.001
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0057 0.0157
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0004
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0181 0.0207
Schistosoma mansoni hypothetical protein 0.0874 0.3259 0.3793
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0076 0.0234 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0156 0.037
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0305 0.0926
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.0054 0.0421
Trichomonas vaginalis ankyrin, putative 0.0016 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0027 0.0075
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0016 0.001
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0016 0.008
Loa Loa (eye worm) hypothetical protein 0.0311 0.1125 0.3101
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0044 0.0114 0.0128
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0016 0.008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0016 0.0081
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0305 0.0916
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0038 0.0239
Onchocerca volvulus 0.0198 0.0695 0.1675
Onchocerca volvulus 0.1105 0.4136 1
Trichomonas vaginalis D-aminoacylase, putative 0.0046 0.0122 0.0288
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0015 0.0025
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0311 0.1125 1
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0016 0.0007 0.0004
Brugia malayi RING zinc finger protein 0.0016 0.0007 0.0018
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.014 0.0479 0.146
Echinococcus granulosus mixed lineage leukemia protein mll 0.002 0.0021 0.0021
Echinococcus multilocularis jumonji domain containing protein 0.004 0.01 0.0097
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0044 0.0113 0.0951
Brugia malayi Zinc finger protein 183 homolog 0.0016 0.0007 0.0019
Brugia malayi hypothetical protein 0.0016 0.0007 0.0018
Brugia malayi aspartic protease BmAsp-2, identical 0.0054 0.0151 0.0415
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0027 0.0028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0165 0.0571 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0016 0.0007 0.0003
Trypanosoma brucei cytochrome P450, putative 0.0046 0.012 0.1018
Mycobacterium ulcerans hypothetical protein 0.0024 0.0038 0.0239
Plasmodium falciparum importin beta, putative 0.0056 0.0161 0.0473
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0055 0.0156 0.1332
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0392 0.1193
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.018 0.0176
Schistosoma mansoni zinc finger protein 0.0016 0.0007 0.0008
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0305 0.3004
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0016 0.0007 0.001
Brugia malayi nuclear hormone receptor 0.0021 0.0027 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0016 0.008
Schistosoma mansoni microtubule-associated protein tau 0.2281 0.8593 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0017 0.0045
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0027 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.014 0.0479 0.0557
Mycobacterium ulcerans esterase/lipase LipP 0.0046 0.0122 0.1108
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0004
Leishmania major cytochrome p450-like protein 0.0018 0.0016 0.0081
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0305 0.0301
Onchocerca volvulus 0.0311 0.1125 0.2714
Brugia malayi Pepsin A precursor 0.0054 0.0151 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0059 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0102 0.024
Schistosoma mansoni eyes absent homolog 0.0067 0.0202 0.0236
Mycobacterium ulcerans beta-lactamase 0.0046 0.0122 0.1108
Echinococcus multilocularis Smad4 0.0016 0.0007 0.0004
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0161 0.1376
Onchocerca volvulus 0.0044 0.0114 0.0268
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0027 0.0075
Loa Loa (eye worm) beta-lactamase 0.0046 0.0122 0.0336
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0019 0.0018 0.002
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0015 0.0003 0.0008
Brugia malayi Neuralized family protein 0.0016 0.0007 0.0018
Plasmodium vivax SET domain protein, putative 0.014 0.0479 0.1452
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0305 0.0926
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0038 0.0104
Echinococcus granulosus Smad4 0.0016 0.0007 0.0005
Schistosoma mansoni hypothetical protein 0.0469 0.1723 0.2006
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0038 0.0239
Onchocerca volvulus 0.0058 0.0168 0.0399
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0007 0.0008
Mycobacterium tuberculosis Conserved protein 0.0046 0.0122 0.1082
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0059 0.0137
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0336
Brugia malayi Muscleblind-like protein 0.0245 0.0877 0.2416
Onchocerca volvulus Protein neuralized homolog 0.0016 0.0007 0.0008
Brugia malayi hypothetical protein 0.0015 0.0003 0.0008
Trichomonas vaginalis ion channel nompc, putative 0.0016 0.0007 0.0009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0151 0.0175
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0007 0.0006
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0305 0.0893
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0161 0.1376
Brugia malayi SWIB/MDM2 domain containing protein 0.0874 0.3259 0.8984
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0119
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0311 0.1125 0.3101
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0057 0.0062
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0054 0.0421
Schistosoma mansoni lamin 0.0044 0.0114 0.0133
Echinococcus granulosus cell growth regulator with ring finger domain 0.0016 0.0007 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0152 0.0523 0.0609
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0007 0.0012
Schistosoma mansoni hypothetical protein 0.0874 0.3259 0.3793
Brugia malayi hypothetical protein 0.0016 0.0007 0.0018
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0045 0.0347
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Schistosoma mansoni peter pan-related 0.0016 0.0007 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0165 0.0571 0.0665
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0044 0.0113 0.0951
Loa Loa (eye worm) hypothetical protein 0.0152 0.0523 0.1441
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0038 0.0239
Loa Loa (eye worm) hypothetical protein 0.0369 0.1346 0.3709
Schistosoma mansoni rnf5 0.0016 0.0007 0.0008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0025 0.004 0.0042
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Echinococcus granulosus cpg binding protein 0.0063 0.0186 0.0212
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0076 0.0234 0.0708
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0027 0.0058
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0016 0.0014
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0017 0.009
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0021 0.0027 0.0024
Brugia malayi beta-lactamase family protein 0.0046 0.0122 0.0335
Schistosoma mansoni RNA binding protein 0.0311 0.1125 0.1309
Brugia malayi hypothetical protein 0.0016 0.0007 0.0018
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0057 0.0154
Toxoplasma gondii hypothetical protein 0.0033 0.007 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0034
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0686 0.2546 0.7017
Schistosoma mansoni fusion 0.0311 0.1125 0.1309
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0027 0.0032
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0014 0.0001 0.0001
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0016 0.0007 0.0009
Brugia malayi regulator of G-protein signaling egl-10 0.0015 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.018 0.1707
Schistosoma mansoni hypothetical protein 0.0076 0.0235 0.0273
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0038 0.1369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0102 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0156 0.037
Plasmodium vivax plasmepsin IV, putative 0.0054 0.0151 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0034
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0044 0.0114 0.011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0027 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0027 0.0024
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0874 0.3259 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0165 0.0571 0.0661
Trichomonas vaginalis hypothetical protein 0.0016 0.0007 0.0009
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.018 0.0209
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0075
Plasmodium vivax aspartyl protease, putative 0.0054 0.0151 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0102 0.024
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0055 0.0156 0.1332
Echinococcus granulosus importin subunit beta 1 0.0056 0.0161 0.0183
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.00000019749
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Mycobacterium tuberculosis Probable lipase LipD 0.0046 0.0122 0.1082
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Brugia malayi beta-lactamase 0.0046 0.0122 0.0335
Schistosoma mansoni ring finger protein 151 0.0016 0.0007 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0016 0.001
Schistosoma mansoni cpg binding protein 0.0063 0.0186 0.0216
Loa Loa (eye worm) RiNg Finger protein family member 0.0016 0.0007 0.002
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0016 0.008
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0027 0.0024
Entamoeba histolytica hypothetical protein 0.0076 0.0235 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0007 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0046 0.0122 0.0288
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0027 0.0024
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0186 0.0513
Schistosoma mansoni TRABID protein (C64 family) 0.0311 0.1125 0.1309
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0803 0.2991 0.8244
Schistosoma mansoni zinc finger protein 0.0017 0.001 0.0012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0165 0.0571 0.1575
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0165 0.0571 0.0568
Echinococcus granulosus snurportin 1 0.0602 0.223 0.2592
Trichomonas vaginalis penicillin-binding protein, putative 0.0046 0.0122 0.0288
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0007 0.0006
Echinococcus granulosus lamin 0.0044 0.0114 0.0129
Echinococcus granulosus geminin 0.0436 0.1601 0.186
Brugia malayi Pre-SET motif family protein 0.014 0.0479 0.1319
Loa Loa (eye worm) hypothetical protein 0.0082 0.0257 0.0708
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0054 0.0123
Echinococcus multilocularis ring finger protein 113a 0.0016 0.0007 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0059 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0334 0.1214 0.141
Giardia lamblia PHD finger protein 15 0.0029 0.0057 0.3372
Leishmania major alpha glucosidase II subunit, putative 0.0076 0.0234 0.2033
Mycobacterium leprae conserved hypothetical protein 0.0046 0.0122 0.3668
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0009
Brugia malayi jmjC domain containing protein 0.004 0.0098 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Entamoeba histolytica Ran family GTPase 0.0042 0.0104 0.4273
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0016 0.0007 0.0003
Brugia malayi Pre-SET motif family protein 0.0971 0.3628 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0055 0.0156 0.0428
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0305 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.0027 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0027 0.0075
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0016 0.0007 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0027 0.0075
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0027 0.0024
Echinococcus multilocularis neuropeptide receptor A26 0.0288 0.1037 0.1034
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.0054 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0122 0.1029
Echinococcus multilocularis RING finger protein 185 0.0016 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0311 0.1125 0.3101
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0057 0.0164
Brugia malayi hypothetical protein 0.0016 0.0009 0.0024
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0007 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0165 0.0571 0.0661
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0057 0.0066
Brugia malayi hypothetical protein 0.0076 0.0235 0.0646
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0027 0.0032
Mycobacterium ulcerans hypothetical protein 0.0046 0.0122 0.1108
Mycobacterium tuberculosis Conserved protein 0.0046 0.0122 0.1082
Schistosoma mansoni hypothetical protein 0.0217 0.0769 0.0895
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Onchocerca volvulus 0.0016 0.0007 0.0008
Brugia malayi RNA binding protein 0.0063 0.0186 0.0512
Toxoplasma gondii hypothetical protein 0.0016 0.0007 0.001
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0016 0.0007 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0038 0.0279
Loa Loa (eye worm) hypothetical protein 0.0028 0.0051 0.0142
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0104 0.03
Plasmodium falciparum plasmepsin VIII, putative 0.0054 0.0151 0.0443
Leishmania major importin beta-1 subunit, putative 0.0046 0.012 0.1015
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0122 0.1029
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0151 0.0175
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0007 0.0009
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0054 0.0421
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0009
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0234 0.0559
Onchocerca volvulus 0.0046 0.0122 0.0287
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0311 0.1125 0.2714
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0152 0.0523 0.0609
Plasmodium vivax aspartyl protease, putative 0.0054 0.0151 0.0443
Echinococcus granulosus dnaJ subfamily B 0.0528 0.1947 0.2263
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0016 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0007 0.0009
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0007 0.0009
Echinococcus multilocularis voltage gated potassium channel 0.0016 0.0007 0.0003
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0181 0.0178
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0027 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0102 0.024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0027 0.0075
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0016 0.0081
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.0839 0.2314
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.0839 0.2314
Trichomonas vaginalis maltase-glucoamylase, putative 0.0076 0.0234 0.0559
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0007 0.002
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0038 0.0104
Giardia lamblia Protein 21.1 0.0016 0.0007 0.0000014825
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0186 0.0512
Trypanosoma cruzi hypothetical protein, conserved 0.0311 0.1125 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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