Detailed information for compound 1324023

Basic information

Technical information
  • TDR Targets ID: 1324023
  • Name: 2-(3,4-dichlorophenyl)-3-hydroxyquinazolin-4- one
  • MW: 307.132 | Formula: C14H8Cl2N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.3 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1Cl)c1nc2ccccc2c(=O)n1O
  • InChi: 1S/C14H8Cl2N2O2/c15-10-6-5-8(7-11(10)16)13-17-12-4-2-1-3-9(12)14(19)18(13)20/h1-7,20H
  • InChiKey: BVLIDGAETAXMEG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3,4-dichlorophenyl)-3-hydroxy-quinazolin-4-one
  • 2-(3,4-dichlorophenyl)-3-hydroxy-4-quinazolinone
  • 12J-561S
  • ZINC04059958
  • 2-(3,4-dichlorophenyl)-3-hydroxy-4(3H)-quinazolinone
  • MLS000540440
  • SMR000125698
  • Oprea1_515141

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major trypanothione reductase 0.0086 0.0995 0.2097
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.004 0.0372 0.0357
Loa Loa (eye worm) hypothetical protein 0.0026 0.0181 0.0171
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0014 0.0024 0.0008
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0031 0.025 0.0236
Loa Loa (eye worm) hypothetical protein 0.0058 0.0619 0.061
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0142 0.0133
Trypanosoma brucei ISWI complex protein 0.0017 0.0064 0.0122
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0026 0.0181 0.0166
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.215 0.4545
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0862 0.0848
Schistosoma mansoni cpg binding protein 0.0042 0.0397 0.0382
Loa Loa (eye worm) hypothetical protein 0.0058 0.0619 0.061
Onchocerca volvulus 0.0174 0.2172 0.2628
Echinococcus multilocularis ATP binding cassette sub family B 0.0015 0.004 0.0025
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0239 0.0587
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0375 0.0353
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.025 0.0229
Plasmodium falciparum thioredoxin reductase 0.003 0.0239 0.2326
Mycobacterium ulcerans hypothetical protein 0.0192 0.2411 0.6148
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0081 0.016
Trichomonas vaginalis glucosylceramidase, putative 0.0473 0.6179 0.7534
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0015 0.004 0.0182
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0064 0.0697 0.0676
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0013 0.0009 0.0016
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0206 0.0225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0064 0.0697 0.0683
Loa Loa (eye worm) multidrug resistance protein 3 0.0026 0.0181 0.0171
Brugia malayi PAS domain containing protein 0.0104 0.1227 0.1208
Loa Loa (eye worm) hypoxia-induced factor 1 0.0321 0.4139 0.4133
Brugia malayi Cytochrome P450 family protein 0.0026 0.0188 0.0166
Echinococcus multilocularis Regulator of G protein signaling 20 0.0014 0.0024 0.0008
Loa Loa (eye worm) hypothetical protein 0.0089 0.1033 0.1025
Onchocerca volvulus 0.0028 0.0206 0.0225
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0081 0.0609
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0026 0.0181 0.0213
Schistosoma mansoni axis inhibition protein axin 0.0014 0.0024 0.0008
Schistosoma mansoni multidrug resistance protein 0.0026 0.0181 0.0166
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0024
Echinococcus granulosus lamin 0.0089 0.1033 0.102
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0239 0.0493
Entamoeba histolytica ATP-binding cassette protein, putative 0.0043 0.0418 0.0504
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0188 0.0386
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0026 0.0188 0.0386
Entamoeba histolytica hypothetical protein 0.0014 0.0024 0.0021
Trypanosoma cruzi Aph-1 protein, putative 0.0296 0.3797 0.8037
Mycobacterium ulcerans 6-phosphofructokinase 0.0079 0.0892 0.226
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0862 0.0842
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0026 0.0188 0.0386
Schistosoma mansoni hypothetical protein 0.0014 0.0027 0.0012
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0081 0.016
Brugia malayi ABC transporter family protein 0.0026 0.0181 0.0159
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0206 0.0191
Schistosoma mansoni smdr1 0.0015 0.004 0.0025
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0026 0.0188 0.0386
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0058 0.0619 0.0605
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0043 0.0418 0.0874
Schistosoma mansoni hypothetical protein 0.0183 0.2289 0.2278
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0239 0.0493
Echinococcus multilocularis nuclear receptor nhr 48 0.0028 0.0206 0.0191
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0059 0.063 0.0616
Plasmodium vivax SET domain protein, putative 0.0079 0.0902 0.3103
Echinococcus multilocularis 0.0026 0.0188 0.0173
Onchocerca volvulus 0.0027 0.0199 0.0216
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0014 0.0024 0.0014
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0203 0.0188
Echinococcus multilocularis axis inhibition protein axin 0.0014 0.0024 0.0008
Mycobacterium leprae Conserved hypothetical protein 0.0026 0.0188 0.0382
Loa Loa (eye worm) runx1 0.0045 0.0435 0.0426
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0099 0.0089
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0028 0.0206 0.0191
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.004 0.0025
Loa Loa (eye worm) 6-phosphofructokinase 0.0079 0.0892 0.0884
Entamoeba histolytica phosphofructokinase, putative 0.0079 0.0892 0.1084
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0043 0.0418 0.0874
Loa Loa (eye worm) hypothetical protein 0.0049 0.05 0.0491
Brugia malayi follicle stimulating hormone receptor 0.0612 0.8037 0.8032
Plasmodium vivax 6-phosphofructokinase, putative 0.0021 0.0122 0.0393
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0239 0.2224
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0075 0.0053
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0017 0.0068 0.0149
Toxoplasma gondii exonuclease III APE 0.004 0.0375 0.3622
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0375 0.0313
Loa Loa (eye worm) PXA domain-containing protein 0.0014 0.0024 0.0014
Trypanosoma brucei multidrug resistance protein E 0.0043 0.0418 0.0874
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0026 0.0188 0.0457
Trichomonas vaginalis abcb9, putative 0.0026 0.0181 0.0213
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0013
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0015 0.004 0.0072
Trichomonas vaginalis penicillin-binding protein, putative 0.0069 0.0757 0.0917
Giardia lamblia ABC transporter, putative 0.0043 0.0418 0.0473
Loa Loa (eye worm) phosphofructokinase 0.0079 0.0892 0.0884
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0612 0.8037 0.8035
Leishmania major cytochrome p450-like protein 0.0026 0.0188 0.0386
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0197
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.0619 0.0605
Echinococcus granulosus regulator of G protein signaling 7 0.0014 0.0024 0.0008
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0031 0.025 0.0241
Loa Loa (eye worm) nuclear hormone receptor 0.0028 0.0206 0.0197
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0081 0.0072
Loa Loa (eye worm) hypothetical protein 0.0061 0.0658 0.0649
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0081 0.0066
Loa Loa (eye worm) hypothetical protein 0.002 0.0108 0.0099
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0013
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0153 0.0131
Brugia malayi bHLH-PAS transcription factor 0.0077 0.0866 0.0846
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0027 0.0199 0.0235
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0752 0.0738
Loa Loa (eye worm) hypothetical protein 0.0027 0.0199 0.0189
Brugia malayi POT family protein 0.003 0.0233 0.0212
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0122 0.0142
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0024 0.0008
Brugia malayi ABC transporter family protein 0.0015 0.004 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0058 0.0619 0.0598
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0239 0.5937
Schistosoma mansoni lamin 0.0089 0.1033 0.102
Schistosoma mansoni aldehyde dehydrogenase 0.0044 0.0427 0.0412
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0079 0.0902 0.0888
Plasmodium falciparum ABC transporter B family member 4, putative 0.0015 0.004 0.031
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0048 0.0267
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0239 0.0587
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0197
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0073 0.0821 0.08
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0081 0.0066
Leishmania major protein kinase, putative 0.0027 0.0199 0.0408
Loa Loa (eye worm) hypothetical protein 0.0031 0.025 0.0241
Loa Loa (eye worm) hypothetical protein 0.0155 0.1909 0.1901
Echinococcus granulosus regulator of G protein signaling 7 0.0014 0.0024 0.0008
Brugia malayi TAR-binding protein 0.0076 0.0862 0.0842
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0197
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0199 0.0189
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0026 0.0181 0.0213
Brugia malayi hypothetical protein 0.0052 0.0538 0.0517
Loa Loa (eye worm) CYP4Cod1 0.0045 0.0447 0.0438
Echinococcus multilocularis Protein lozenge 0.0045 0.0435 0.0421
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0203 0.0188
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0044 0.0427 0.0747
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0173 0.215 0.2138
Schistosoma mansoni zinc finger protein 0.0017 0.0064 0.0049
Entamoeba histolytica P-glycoprotein-1 0.0026 0.0181 0.0213
Loa Loa (eye worm) steroid hormone receptor 0.0058 0.0619 0.061
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0026 0.0181 0.0213
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0098 0.1154 0.1141
Echinococcus multilocularis Solute carrier organic anion transporter family 0.002 0.0108 0.0093
Echinococcus multilocularis agrin 0.0014 0.0022 0.0007
Trypanosoma cruzi ISWI complex protein 0.0017 0.0064 0.0122
Plasmodium falciparum multidrug resistance protein 2 0.0015 0.004 0.031
Schistosoma mansoni smdr2 0.0026 0.0181 0.0166
Echinococcus multilocularis zinc finger protein 0.0024 0.0159 0.0144
Giardia lamblia Multidrug resistance-associated protein 1 0.0043 0.0418 0.0473
Plasmodium vivax glutathione reductase, putative 0.0086 0.0995 0.3428
Echinococcus multilocularis multidrug resistance associated protein 4 0.0028 0.0216 0.0201
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0079 0.0892 0.1562
Loa Loa (eye worm) cytochrome P450 0.0026 0.0188 0.0179
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0079 0.0892 0.1879
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0026 0.0181 0.0213
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0375 0.0782
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0473 0.6179 0.617
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.0427 0.1068
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.1164 0.1144
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0206 0.0191
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0028 0.0206 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0058 0.0619 0.061
Echinococcus multilocularis expressed protein 0.0014 0.0022 0.0007
Onchocerca volvulus 0.0079 0.0902 0.1076
Trichomonas vaginalis D-aminoacylase, putative 0.0069 0.0757 0.0917
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0015 0.004 0.0072
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0076 0.0851 0.0837
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0015 0.004 0.0072
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0015 0.004 0.0018
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0026 0.0188 0.0457
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.025 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0058 0.0619 0.0598
Echinococcus multilocularis regulator of G protein signaling 3 0.0014 0.0024 0.0008
Brugia malayi hypothetical protein 0.0028 0.0206 0.0184
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0043 0.0418 0.0874
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0015 0.004 0.0182
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0432 0.0418
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0058 0.0619 0.0605
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0043 0.0418 0.0874
Loa Loa (eye worm) hypothetical protein 0.0069 0.0757 0.0748
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0042 0.0394 0.0379
Plasmodium falciparum ABC transporter B family member 6, putative 0.0015 0.004 0.031
Loa Loa (eye worm) 6-phosphofructokinase 0.0079 0.0892 0.0884
Toxoplasma gondii histone lysine methyltransferase SET1 0.0085 0.0971 0.975
Schistosoma mansoni aldehyde dehydrogenase 0.0044 0.0427 0.0412
Loa Loa (eye worm) hypothetical protein 0.0348 0.45 0.4495
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0697 0.0683
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0027 0.0199 0.0235
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0026 0.0181 0.1627
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0026 0.0188 0.0329
Trichomonas vaginalis glucosylceramidase, putative 0.0473 0.6179 0.7534
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0091 0.1063 0.1049
Brugia malayi hypothetical protein 0.002 0.0108 0.0086
Toxoplasma gondii ABC1 family protein 0.0069 0.0757 0.7552
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0058 0.0619 0.0598
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0058 0.0619 0.0598
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0375 0.127
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0044 0.0427 0.0412
Echinococcus multilocularis axis inhibition protein axin 0.0014 0.0024 0.0008
Entamoeba histolytica P-glycoprotein-2 0.0026 0.0181 0.0213
Brugia malayi hypothetical protein 0.0348 0.45 0.4487
Echinococcus multilocularis regulator of G protein signaling 7 0.0014 0.0024 0.0008
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0206 0.0184
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0014 0.0024 0.0021
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0081 0.016
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0015 0.004 0.0182
Brugia malayi ABC transporter transmembrane region family protein 0.0015 0.0033 0.0011
Brugia malayi glutathione reductase 0.0086 0.0995 0.0975
Brugia malayi Bromodomain containing protein 0.0042 0.0404 0.0382
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.4723 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0081 0.0731
Entamoeba histolytica P-glycoprotein 5, putative 0.0026 0.0181 0.0213
Brugia malayi ABC transporter family protein 0.0015 0.004 0.0018
Mycobacterium tuberculosis Probable hydrolase 0.0069 0.0757 0.1325
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0752 0.0738
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0027 0.0199 0.0184
Schistosoma mansoni hypothetical protein 0.0073 0.0809 0.0796
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0021 0.0122 0.0142
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0197
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0197 0.2479 0.4339
Onchocerca volvulus 0.002 0.0108 0.0105
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0199 0.0235
Echinococcus granulosus axis inhibition protein axin 0.0014 0.0024 0.0008
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0026 0.0188 0.0457
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0015 0.004 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0697 0.0683
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0024 0.0008
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.009 0.0074
Echinococcus granulosus ATP binding cassette sub family B 0.0015 0.0033 0.0018
Echinococcus granulosus thyroid hormone receptor alpha 0.0028 0.0206 0.0191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.8187 0.9985
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0014 0.0024 0.0008
Loa Loa (eye worm) hypothetical protein 0.0069 0.0757 0.0748
Schistosoma mansoni hypothetical protein 0.0017 0.0064 0.0049
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0197
Loa Loa (eye worm) hypothetical protein 0.002 0.0108 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0862 0.0848
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0028 0.0206 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0862 0.0848
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0015 0.004 0.0182
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1769 0.1761
Onchocerca volvulus 0.002 0.0108 0.0105
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0058 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0014
Loa Loa (eye worm) hypothetical protein 0.0058 0.0619 0.061
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0069 0.0757 0.1914
Brugia malayi Steroid receptor seven-up type 2 0.0058 0.0619 0.0598
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0239 0.0252
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0197
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0026 0.0181 0.0166
Brugia malayi hypothetical protein 0.0014 0.0024 0.0001
Schistosoma mansoni hypothetical protein 0.0023 0.0147 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0147 0.0138
Schistosoma mansoni hypothetical protein 0.0447 0.5822 0.5815
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0058 0.0619 0.061
Echinococcus granulosus lamin dm0 0.0089 0.1033 0.102
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0024 0.0008
Trichomonas vaginalis taga, putative 0.0026 0.0181 0.0213
Giardia lamblia MRP-like ABC transporter 0.0043 0.0418 0.0473
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.0427 0.1068
Loa Loa (eye worm) hypothetical protein 0.0031 0.025 0.0241
Entamoeba histolytica ATP-binding cassette protein, putative 0.0043 0.0418 0.0504
Schistosoma mansoni cytochrome P450 0.0026 0.0188 0.0173
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0058 0.0619 0.0598
Onchocerca volvulus 0.0026 0.0181 0.0194
Loa Loa (eye worm) agrin synaptic family protein 0.0014 0.0022 0.0013
Trichomonas vaginalis ABC transporter, putative 0.0026 0.0181 0.0213
Plasmodium falciparum multidrug resistance-associated protein 1 0.0015 0.004 0.031
Echinococcus granulosus zinc finger protein 0.0024 0.0159 0.0144
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0064 0.0697 0.0683
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0081 0.0609
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0043 0.0414 0.04
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0139 0.1698 0.1686
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0026 0.0188 0.0329
Loa Loa (eye worm) hypothetical protein 0.0098 0.1154 0.1146
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0024 0.0021
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0375 0.0419
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0375 0.045
Onchocerca volvulus 0.0073 0.0821 0.0976
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.4723 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0058 0.0619 0.0605
Trichomonas vaginalis glucosylceramidase, putative 0.0473 0.6179 0.7534
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0447 0.0438
Schistosoma mansoni multidrug resistance protein 0.0015 0.004 0.0025
Brugia malayi cytoplasmic intermediate filament protein 0.0048 0.0478 0.0457
Schistosoma mansoni hypothetical protein 0.0026 0.0188 0.0173
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0239 0.0493
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0068 0.0149
Toxoplasma gondii phosphofructokinase PFKII 0.0021 0.0122 0.103
Loa Loa (eye worm) RecQ helicase 0.0024 0.0153 0.0144
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0239 0.2326
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0239 0.0284
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0081 0.0066
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0026 0.0188 0.0329
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0206 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0862 0.0848
Brugia malayi P-glycoprotein-like protein 0.0015 0.004 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0122 0.0142
Mycobacterium tuberculosis Conserved protein 0.0069 0.0757 0.1325
Trypanosoma brucei cytochrome P450, putative 0.0045 0.0447 0.0935
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0068 0.0045
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0122 0.0142
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0068 0.0131
Brugia malayi hypothetical protein 0.0028 0.0206 0.0184
Loa Loa (eye worm) hypothetical protein 0.0058 0.0619 0.061
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0058 0.0619 0.073
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0026 0.0181 0.0213
Loa Loa (eye worm) hypothetical protein 0.0061 0.0658 0.0649
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.8187 0.9985
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1769 0.1761
Mycobacterium tuberculosis Probable esterase LipL 0.0069 0.0757 0.1325
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0026 0.0181 0.0213
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.8187 0.9985
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.4723 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.1909 0.1901
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0239 0.0587
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0058 0.0619 0.0598
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0052 0.0538 0.0524
Loa Loa (eye worm) hypothetical protein 0.0058 0.0619 0.061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0064 0.0697 0.0688
Brugia malayi multidrug resistance related protein 1 0.0043 0.0418 0.0397
Echinococcus multilocularis expressed protein 0.027 0.346 0.3451
Loa Loa (eye worm) hypothetical protein 0.0356 0.4604 0.4599
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0524 0.1099
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0021 0.0122 0.011
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0026 0.0188 0.0329
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0026 0.0188 0.0329
Leishmania major cytochrome p450-like protein 0.0026 0.0188 0.0386
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0058 0.0619 0.0598
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0043 0.0418 0.0874
Onchocerca volvulus 0.0058 0.0619 0.073
Entamoeba histolytica phosphofructokinase, putative 0.0079 0.0892 0.1084
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0069 0.0757 0.1325
Schistosoma mansoni thyroid hormone receptor 0.0197 0.248 0.2468
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0623 0.8187 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0014
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0086 0.0071
Brugia malayi hypothetical protein 0.0174 0.2172 0.2154
Echinococcus multilocularis regulator of G protein signaling 0.0014 0.0024 0.0008
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0042 0.0394 0.0822
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.009 0.0074
Schistosoma mansoni nuclear receptor 0.0028 0.0206 0.0191
Loa Loa (eye worm) hypothetical protein 0.0025 0.0174 0.0164
Echinococcus multilocularis regulator of G protein signaling 7 0.0014 0.0024 0.0008
Brugia malayi ecdysteroid receptor 0.0058 0.0619 0.0598
Brugia malayi photoreceptor-specific nuclear receptor 0.0058 0.0619 0.0598
Plasmodium vivax hypothetical protein, conserved 0.0069 0.0757 0.26
Brugia malayi multidrug resistance protein 3 0.0026 0.0181 0.0159
Brugia malayi nuclear receptor NHR-67 0.0028 0.0206 0.0184
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.1154 0.1141
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0447 0.0935
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0473 0.6179 0.6175
Brugia malayi MH2 domain containing protein 0.0144 0.1769 0.1751
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0394 0.0984
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0079 0.0892 0.1879
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0079 0.0892 0.0955
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0239 0.0493
Brugia malayi latrophilin 2 splice variant baaae 0.0023 0.0147 0.0125
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0026 0.0181 0.1627
Loa Loa (eye worm) ABC transporter 0.0015 0.004 0.0031
Brugia malayi Thioredoxin reductase 0.0086 0.0995 0.0975
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0058 0.0619 0.0598
Loa Loa (eye worm) hypothetical protein 0.0073 0.0821 0.0812
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0021 0.0122 0.4932
Brugia malayi isocitrate dehydrogenase 0.0018 0.0081 0.0059
Plasmodium falciparum multidrug resistance-associated protein 2 0.0015 0.004 0.031
Brugia malayi ABC transporter 0.0015 0.0033 0.0011
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0026 0.0181 0.0213
Entamoeba histolytica hypothetical protein 0.0014 0.0024 0.0021
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0026 0.0181 0.0213
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0132 0.011
Mycobacterium tuberculosis Probable lipase LipE 0.0069 0.0757 0.1325
Schistosoma mansoni axis inhibition protein axin 0.0014 0.0024 0.0008
Treponema pallidum fructose-bisphosphate aldolase 0.0623 0.8187 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0058 0.0619 0.0605
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0199 0.0235
Trichomonas vaginalis phosphofructokinase, putative 0.0079 0.0892 0.1082
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0219 0.2773 0.7052
Trypanosoma cruzi hypothetical protein 0.0028 0.0216 0.0445
Echinococcus multilocularis ATP binding cassette sub family B 0.0015 0.004 0.0025
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0239 0.0284
Onchocerca volvulus Putative organic anion transporter 0.002 0.0108 0.0105
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0068 0.0149
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.4723 1
Echinococcus multilocularis dnaJ subfamily B 0.0595 0.7805 0.7802
Loa Loa (eye worm) hypothetical protein 0.0069 0.0757 0.0748
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0153 0.0138
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0017 0.0068 0.0118
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0675 0.1418
Echinococcus granulosus ATP binding cassette sub family B 0.0015 0.004 0.0025
Echinococcus granulosus bloom syndrome protein 0.0024 0.0153 0.0138
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0026 0.0181 0.0213
Echinococcus multilocularis cpg binding protein 0.0046 0.0457 0.0443
Brugia malayi A-kinase anchor protein 10, precursor 0.0014 0.0024 0.0001
Plasmodium falciparum thioredoxin reductase 0.0086 0.0995 1
Leishmania major cytochrome p450-like protein 0.0045 0.0447 0.0935
Brugia malayi nuclear receptor RXR 0.0028 0.0206 0.0184
Loa Loa (eye worm) hypothetical protein 0.0043 0.0418 0.0409
Echinococcus granulosus beta-adrenergic receptor kinase 0.0014 0.0024 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0024 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0024 0.0021
Loa Loa (eye worm) glutathione reductase 0.0086 0.0995 0.0987
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.004 0.0041
Loa Loa (eye worm) hypothetical protein 0.0031 0.025 0.0241
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0026 0.0188 0.0329
Entamoeba histolytica hypothetical protein 0.0052 0.0538 0.0651
Brugia malayi Pre-SET motif family protein 0.0079 0.0902 0.0882
Loa Loa (eye worm) hypothetical protein 0.0031 0.025 0.0241
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0239 0.0493
Giardia lamblia Multidrug resistance-associated protein 1 0.0043 0.0411 0.0464
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0048 0.0478 0.0469
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0081 0.0066
Mycobacterium ulcerans beta-lactamase 0.0069 0.0757 0.1914
Echinococcus granulosus Solute carrier family 22 5 0.075 0.9884 0.9884
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0239 0.2326
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0375 0.0782
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0239 0.0493
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.009 0.0074
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0021 0.0122 0.103
Mycobacterium leprae putative cytochrome p450 0.0026 0.0188 0.0382
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0026 0.0188 0.0457
Entamoeba histolytica acyl-coA synthetase, putative 0.0017 0.0068 0.0075
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0026 0.0181 0.0213
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.025 0.0236
Echinococcus multilocularis musashi 0.0089 0.1033 0.102
Echinococcus multilocularis 0.0015 0.004 0.0025
Trichomonas vaginalis ABC transporter, putative 0.0026 0.0181 0.0213
Trichomonas vaginalis phosphofructokinase, putative 0.0079 0.0892 0.1082
Brugia malayi Regulator of G protein signaling domain containing protein 0.0014 0.0024 0.0001
Brugia malayi beta-lactamase family protein 0.0069 0.0757 0.0737
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0024 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0239 0.0493
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0199 0.0408
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0058 0.0619 0.0605
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.0033 0.0033
Brugia malayi intermediate filament protein 0.0089 0.1033 0.1013
Schistosoma mansoni multidrug resistance protein 0.0026 0.0181 0.0166
Brugia malayi PXA domain containing protein 0.0014 0.0024 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0024 0.0021
Trichomonas vaginalis ABC transporter, putative 0.0026 0.0181 0.0213
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0079 0.0892 0.2199
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0197 0.2479 0.4339
Echinococcus granulosus agrin 0.0014 0.0022 0.0007
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0199 0.0408
Mycobacterium tuberculosis Conserved protein 0.0069 0.0757 0.1325
Echinococcus multilocularis muscleblind protein 0.0155 0.1909 0.1897
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0697 0.0683
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0058 0.0619 0.061
Mycobacterium tuberculosis Probable oxidoreductase 0.0219 0.2773 0.4855
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0026 0.0181 0.0166
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0058 0.0619 0.0605
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0081 0.0066
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0228 0.2886 1
Echinococcus granulosus dnaJ subfamily B 0.0595 0.7805 0.7802
Brugia malayi prostaglandin transporter 0.002 0.0108 0.0086
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0026 0.0181 0.0213
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0013
Echinococcus granulosus single minded 2 0.0077 0.0866 0.0852
Entamoeba histolytica hypothetical protein 0.0052 0.0538 0.0651
Brugia malayi steroid hormone receptor 0.0058 0.0619 0.0598
Loa Loa (eye worm) hypothetical protein 0.0069 0.0757 0.0748
Schistosoma mansoni hypothetical protein 0.0099 0.1164 0.1151
Onchocerca volvulus 0.0017 0.0068 0.0055
Entamoeba histolytica multidrug resistance protein, putative 0.0043 0.0418 0.0504
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0026 0.0181 0.037
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0524 0.1099
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0026 0.0188 0.0457
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0026 0.0181 0.7466
Echinococcus multilocularis survival motor neuron protein 1 0.0486 0.6342 0.6336
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0024 0.0021
Mycobacterium ulcerans hypothetical protein 0.0069 0.0757 0.1914
Entamoeba histolytica ATP-binding cassette protein, putative 0.0043 0.0418 0.0504
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0026 0.0181 0.0166
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0026 0.0188 0.0457
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0132 0.011
Schistosoma mansoni organic anion transporter 0.002 0.0108 0.0093
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0197
Trypanosoma brucei hypothetical protein, conserved 0.0069 0.0757 0.1592
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0058 0.0619 0.061
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0375 0.0451
Brugia malayi Bromodomain containing protein 0.0085 0.0978 0.0958
Schistosoma mansoni cpg binding protein 0.0046 0.0457 0.0443
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0862 0.0854
Loa Loa (eye worm) CXXC zinc finger family protein 0.0042 0.0397 0.0388
Echinococcus multilocularis ATP binding cassette sub family B 0.0025 0.0174 0.0159
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0026 0.0181 0.0213
Plasmodium vivax multidrug resistance protein 1, putative 0.0026 0.0181 0.0595
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0239 0.5937
Loa Loa (eye worm) hypothetical protein 0.0031 0.025 0.0241
Brugia malayi Calcitonin receptor-like protein seb-1 0.0034 0.029 0.0269
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0061 0.0658 0.0649
Toxoplasma gondii hypothetical protein 0.0059 0.0625 0.62
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0199 0.0408
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0068 0.0149
Brugia malayi hypothetical protein 0.0031 0.025 0.0229
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0239 0.0493
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0028 0.0206 0.0191
Trypanosoma cruzi trypanothione reductase, putative 0.0086 0.0995 0.2097
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0199 0.0408
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0014 0.0022 0.0013
Brugia malayi nuclear receptor NHR-88 0.0058 0.0619 0.0598
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0034 0.029 0.0269
Onchocerca volvulus Bile acid receptor homolog 0.0058 0.0619 0.073
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0447 0.0935
Brugia malayi Pre-SET motif family protein 0.0549 0.7186 0.718
Schistosoma mansoni 6-phosphofructokinase 0.0079 0.0892 0.0879
Schistosoma mansoni hypothetical protein 0.0139 0.1698 0.1686
Echinococcus multilocularis multidrug resistance associated protein 7 0.0043 0.0418 0.0404
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0028 0.0206 0.0197
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0017 0.0068 0.0149
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0014
Echinococcus multilocularis multidrug resistance protein 1 0.0026 0.0181 0.0166
Schistosoma mansoni nuclear receptor nhr-48 0.0028 0.0206 0.0191
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0081 0.016
Schistosoma mansoni nuclear hormone receptor 0.0058 0.0619 0.0605
Echinococcus multilocularis follistatin 0.0014 0.0022 0.0007
Brugia malayi Intermediate filament tail domain containing protein 0.0089 0.1033 0.1013
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0015 0.004 0.0078
Schistosoma mansoni jumonji domain containing protein 0.004 0.0372 0.0357
Loa Loa (eye worm) ABC transporter 0.0015 0.004 0.0031
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0024 0.0008
Onchocerca volvulus 0.002 0.0108 0.0105
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0069 0.0757 0.1325
Leishmania major hypothetical protein, conserved 0.0017 0.0064 0.0122
Entamoeba histolytica hypothetical protein 0.0043 0.0418 0.0504
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0026 0.0188 0.0329
Schistosoma mansoni multidrug resistance protein 0.0043 0.0418 0.0404
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0197
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0026 0.0188 0.0457
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0058 0.0619 0.061
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0026 0.0181 0.0213
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0197
Onchocerca volvulus Glucosylceramidase homolog 0.0311 0.3998 0.4861
Schistosoma mansoni multidrug resistance protein 0.0043 0.0418 0.0404
Giardia lamblia Fructose-bisphosphate aldolase 0.0623 0.8187 1
Schistosoma mansoni lozenge 0.0045 0.0435 0.0421
Loa Loa (eye worm) hypothetical protein 0.0041 0.0393 0.0384
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0014 0.0024 0.0008
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0042 0.0394 0.0379
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0043 0.0418 0.0874
Echinococcus multilocularis regulator of G protein signaling 3 0.0014 0.0024 0.0008
Onchocerca volvulus 0.0042 0.0397 0.0458
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0026 0.0188 0.0329
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0239 0.0493
Echinococcus granulosus multidrug resistance associated protein 1 0.0043 0.0418 0.0404
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0015 0.004 0.0182
Loa Loa (eye worm) hypothetical protein 0.0041 0.0393 0.0384
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0021 0.0122 0.1147
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0026 0.0181 0.0166
Schistosoma mansoni coup transcription factor 0.0058 0.0619 0.0605
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0069 0.0757 0.1325
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0058 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0197
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0044 0.0427 0.0412
Toxoplasma gondii hypothetical protein 0.0061 0.0658 0.653
Loa Loa (eye worm) hypothetical protein 0.0356 0.4604 0.4599
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0024 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0058 0.0619 0.0598
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0757 0.1592
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0862 0.0848
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0759 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0473 0.6179 0.7534
Toxoplasma gondii transporter, major facilitator family protein 0.002 0.0108 0.0882
Trichomonas vaginalis glucosylceramidase, putative 0.0311 0.3998 0.4872
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0014 0.0024 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0206 0.0191
Echinococcus granulosus multidrug resistance protein 1 0.0026 0.0181 0.0166
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0017 0.0068 0.0149
Trichomonas vaginalis glucosylceramidase, putative 0.0327 0.4222 0.5146
Echinococcus multilocularis 6 phosphofructokinase 0.0079 0.0892 0.0879
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0026 0.0188 0.0457
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0524 0.1099
Schistosoma mansoni steroid hormone receptor ad4bp 0.0058 0.0619 0.0605
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0021 0.0122 0.1147
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0375 0.0366
Echinococcus granulosus muscleblind protein 0.0155 0.1909 0.1897
Trichomonas vaginalis glucosylceramidase, putative 0.0311 0.3998 0.4872
Brugia malayi sodium-independent organic anion transporter family protein 0.002 0.0108 0.0086
Entamoeba histolytica P-glycoprotein-2, putative 0.0026 0.0181 0.0213
Leishmania major ATP-dependent phosphofructokinase 0.0079 0.0892 0.1879
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.004 0.0025
Brugia malayi orphan nuclear receptor NR2E1 0.0028 0.0206 0.0184
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0375 0.0935
Loa Loa (eye worm) hypothetical protein 0.0034 0.029 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0058 0.0619 0.0598
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0021 0.0122 0.0142
Entamoeba histolytica P-glycoprotein-2, putative 0.0015 0.0033 0.0033
Plasmodium vivax multidrug resistance protein 2, putative 0.0015 0.004 0.0106
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0239 0.0224
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0058 0.0619 0.0605
Onchocerca volvulus 0.0624 0.8201 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0033 0.0033
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0026 0.0188 0.0457
Brugia malayi beta-lactamase 0.0069 0.0757 0.0737
Treponema pallidum NADH oxidase 0.003 0.0239 0.0144
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0239 0.0217
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0087
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0024 0.0008
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0206 0.0191
Echinococcus granulosus multidrug resistance protein 1 0.0026 0.0181 0.0166
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0025 0.0174 0.0159
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0239 0.2224
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.215 0.4545
Schistosoma mansoni 6-phosphofructokinase 0.0079 0.0892 0.0879
Loa Loa (eye worm) hypothetical protein 0.0043 0.0414 0.0405
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0034 0.029 0.0281
Brugia malayi RNA binding protein 0.0076 0.0862 0.0842
Echinococcus granulosus axis inhibition protein axin 0.0014 0.0024 0.0008
Brugia malayi jmjC domain containing protein 0.0044 0.0432 0.0411
Plasmodium vivax ABC transporter B family member 5, putative 0.0015 0.004 0.0106
Echinococcus granulosus ecdysone induced protein 78C 0.0058 0.0619 0.0605
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0026 0.0188 0.0329
Schistosoma mansoni multidrug resistance protein 0.0015 0.0033 0.0018
Schistosoma mansoni cpg binding protein 0.0046 0.0457 0.0443
Brugia malayi hypothetical protein 0.002 0.0108 0.0086
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0042 0.0394 0.0379
Brugia malayi nuclear receptor RXR 0.0031 0.025 0.0229
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0079 0.0902 0.0888
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0081 0.0066
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0239 0.0493
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0068 0.0131
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0375 0.3705
Mycobacterium leprae Probable lipase LipE 0.0069 0.0757 0.185
Loa Loa (eye worm) nuclear receptor NHR-67 0.0028 0.0206 0.0197
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0026 0.0188 0.0457
Loa Loa (eye worm) RGS-3 protein 0.0014 0.0024 0.0014
Trypanosoma brucei Aph-1 protein, putative 0.0296 0.3797 0.8037
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0375 0.0656
Onchocerca volvulus 0.0089 0.1033 0.1236
Schistosoma mansoni z-protein (S1r protein) 0.0014 0.0024 0.0008
Entamoeba histolytica hypothetical protein 0.0052 0.0538 0.0651
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0079 0.0902 0.904
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0122 0.0142
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0375 0.0782
Echinococcus granulosus Regulator of G protein signaling 20 0.0014 0.0024 0.0008
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0026 0.0181 0.0213
Loa Loa (eye worm) hypothetical protein 0.0174 0.2172 0.2164
Trichomonas vaginalis esterase, putative 0.0069 0.0757 0.0917
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0069 0.0757 0.0743
Loa Loa (eye worm) hypothetical protein 0.0058 0.0619 0.061
Loa Loa (eye worm) RNA binding protein 0.0076 0.0862 0.0854
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0369 0.0354
Echinococcus multilocularis muscleblind protein 1 0.0155 0.1909 0.1897
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0014
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.0199 0.0184
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0058 0.0619 0.0605
Echinococcus granulosus Solute carrier organic anion transporter family 0.002 0.0108 0.0093
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0026 0.0188 0.0329
Loa Loa (eye worm) hypothetical protein 0.0043 0.0411 0.0402
Echinococcus multilocularis thyroid hormone receptor alpha 0.0197 0.248 0.2468
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0058 0.0619 0.061
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0026 0.0181 0.0213
Echinococcus multilocularis geminin 0.0447 0.5822 0.5815
Brugia malayi hypothetical protein 0.0031 0.025 0.0229
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0058
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0015 0.004 0.0078
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0089 0.1033 0.1025
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0081 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.1154 0.1141
Echinococcus granulosus nuclear receptor nhr 48 0.0028 0.0206 0.0191
Echinococcus multilocularis thioredoxin glutathione reductase 0.0086 0.0995 0.0982
Schistosoma mansoni bromodomain containing protein 0.0072 0.0805 0.0791
Brugia malayi hypothetical protein 0.0356 0.4604 0.4592
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.0427 0.1068
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0026 0.0181 0.0213
Schistosoma mansoni lamin 0.0089 0.1033 0.102
Echinococcus multilocularis beta LACTamase domain containing family member 0.0069 0.0757 0.0743
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0026 0.0188 0.0457
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0069 0.0757 0.0748
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0375 0.045
Loa Loa (eye worm) intermediate filament protein 0.0089 0.1033 0.1025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0069 0.0757 0.0743
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0026 0.0181 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0199 0.0235
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0058 0.0619 0.0605
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0026 0.0181 0.0213
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0122 0.0142
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0026 0.0188 0.0329
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0199 0.0408
Schistosoma mansoni multidrug resistance protein 0.0043 0.0418 0.0404
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0081 0.0251
Schistosoma mansoni multidrug resistance protein 0.0043 0.0418 0.0404
Leishmania major ABC-thiol transporter 0.0043 0.0418 0.0874
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0015 0.004 0.0078
Toxoplasma gondii 6-phosphofructokinase 0.0021 0.0122 0.103
Toxoplasma gondii cytochrome p450 superfamily protein 0.0026 0.0188 0.1704
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0026 0.0188 0.0329
Mycobacterium ulcerans putative regulatory protein 0.0077 0.0866 0.2193
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.215 0.4545
Loa Loa (eye worm) hypothetical protein 0.0486 0.6342 0.6339
Plasmodium vivax 6-phosphofructokinase, putative 0.0021 0.0122 0.0393
Brugia malayi 6-phosphofructokinase 0.0079 0.0892 0.0872
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0206 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0058 0.0619 0.0598
Plasmodium falciparum glutathione reductase 0.003 0.0239 0.2326
Brugia malayi PXA domain containing protein 0.0014 0.0024 0.0001
Echinococcus granulosus multidrug resistance protein 1 0.0026 0.0181 0.0166
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0043 0.0418 0.4071
Echinococcus granulosus 6 phosphofructokinase 0.0079 0.0892 0.0879
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0058 0.0619 0.061
Brugia malayi nuclear hormone receptor family member odr-7 0.0028 0.0206 0.0184
Onchocerca volvulus 0.0069 0.0757 0.0899
Schistosoma mansoni follistatin 0.0014 0.0022 0.0007
Brugia malayi ABC transporter transmembrane region family protein 0.0043 0.0418 0.0397
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.0619 0.0605
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0199 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0058 0.0619 0.0598
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0028 0.0206 0.0191
Brugia malayi sodium-independent organic anion transporter family protein 0.002 0.0108 0.0086
Onchocerca volvulus Putative organic anion transporter 0.002 0.0108 0.0105
Brugia malayi cytochrome P450 0.0026 0.0188 0.0166
Loa Loa (eye worm) hypothetical protein 0.002 0.0108 0.0099
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0015 0.004 0.0182
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0015 0.004 0.0072
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0015 0.004 0.0072
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0524 0.1099
Mycobacterium tuberculosis Probable lipase LipD 0.0069 0.0757 0.1325
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0375 1
Echinococcus granulosus multidrug resistance associated protein 7 0.0043 0.0418 0.0404
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0206 0.0191
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0058 0.0619 0.0605
Trichomonas vaginalis D-aminoacylase, putative 0.0069 0.0757 0.0917
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0043 0.0414 0.04
Onchocerca volvulus 0.0077 0.0866 0.1032
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0026 0.0188 0.0457
Echinococcus granulosus histone lysine methyltransferase setb 0.0098 0.1154 0.1141
Trichomonas vaginalis glucosylceramidase, putative 0.0473 0.6179 0.7534
Loa Loa (eye worm) ABC transporter 0.0015 0.004 0.0031
Brugia malayi jmjC domain containing protein 0.004 0.0372 0.035
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0026 0.0188 0.0457
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0219 0.2773 0.4855
Schistosoma mansoni aryl hydrocarbon receptor 0.0104 0.1227 0.1214
Leishmania major hypothetical protein, conserved 0.0069 0.0757 0.1592
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0031
Brugia malayi Muscleblind-like protein 0.0155 0.1909 0.1891
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0028 0.0206 0.0184
Schistosoma mansoni zinc finger protein 0.0024 0.0159 0.0144
Brugia malayi nuclear hormone receptor 0.0058 0.0619 0.0598
Plasmodium vivax ABC transporter B family member 3, putative 0.0015 0.004 0.0106
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0197 0.2479 0.6292
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0045 0.0447 0.112
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.0619 0.0605
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0394 0.0984
Loa Loa (eye worm) beta-lactamase 0.0069 0.0757 0.0748
Trichomonas vaginalis glucosylceramidase, putative 0.0327 0.4222 0.5146
Onchocerca volvulus 0.0069 0.0757 0.0899
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0026 0.0188 0.0329
Onchocerca volvulus 0.0089 0.1033 0.1236
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0239 0.0493
Plasmodium falciparum ABC transporter B family member 5, putative 0.0015 0.004 0.031
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0058 0.0619 0.0605
Plasmodium vivax ABC transporter B family member 4, putative 0.0015 0.004 0.0106
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0432 0.0418
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0026 0.0188 0.0329
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0042 0.0394 0.0372
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0015 0.0033 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0058
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0203 0.0188
Mycobacterium ulcerans hypothetical protein 0.0017 0.0068 0.0149
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0052 0.0538 0.0524
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0304 0.3916 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0043 0.0418 0.0473
Trypanosoma cruzi MFS transporter, putative 0.002 0.0108 0.0216
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0086 0.0995 0.1742
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0014 0.0024 0.0008
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0026 0.0181 0.0166
Brugia malayi ABC transporter family protein 0.0015 0.004 0.0018
Echinococcus granulosus thioredoxin glutathione reductase 0.0086 0.0995 0.0982
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0036 0.0324 0.0315
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0026 0.0188 0.0457
Loa Loa (eye worm) hypothetical protein 0.0069 0.0757 0.0748
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0026 0.0188 0.0457
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0549 0.7186 0.7183
Echinococcus granulosus organic anion transporting polypeptide 30B 0.002 0.0108 0.0093
Trichomonas vaginalis D-aminoacylase, putative 0.0069 0.0757 0.0917
Entamoeba histolytica P-glycoprotein-5 0.0026 0.0181 0.0213
Brugia malayi ecdysone receptor 0.0028 0.0206 0.0184
Loa Loa (eye worm) hypothetical protein 0.0043 0.0418 0.0409
Echinococcus multilocularis lamin dm0 0.0089 0.1033 0.102
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0014 0.0024 0.0014
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0017 0.0068 0.0071
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0304 0.3916 0.6855
Echinococcus multilocularis multidrug resistance associated protein 1 0.0043 0.0418 0.0404
Entamoeba histolytica P-glycoprotein 6, putative 0.0015 0.004 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0026 0.0188 0.0329
Loa Loa (eye worm) sodium-independent organic anion transporter 0.002 0.0108 0.0099
Echinococcus multilocularis lamin 0.0089 0.1033 0.102
Loa Loa (eye worm) hypothetical protein 0.0042 0.0405 0.0396
Brugia malayi nuclear hormone receptor 0.0028 0.0206 0.0184
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0239 0.0418
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0447 0.0438
Trichomonas vaginalis adenylate cyclase, putative 0.0027 0.0199 0.0235
Entamoeba histolytica phosphofructokinase, putative 0.0079 0.0892 0.1084
Trichomonas vaginalis abcb9, putative 0.0026 0.0181 0.0213
Plasmodium vivax thioredoxin reductase, putative 0.0086 0.0995 0.3428
Echinococcus multilocularis ecdysone induced protein 78C 0.0058 0.0619 0.0605
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.0619 0.0605
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0623 0.8187 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0197
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0122 0.0142
Brugia malayi PHD-finger family protein 0.003 0.0238 0.0216
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0081 0.0143
Brugia malayi ABC transporter transmembrane region family protein 0.0015 0.004 0.0018
Echinococcus multilocularis FTZ F1 alpha 0.0058 0.0619 0.0605
Echinococcus granulosus cpg binding protein 0.0046 0.0457 0.0443
Mycobacterium tuberculosis Conserved protein 0.0069 0.0757 0.1325
Brugia malayi tailless protein 0.0028 0.0206 0.0184
Brugia malayi ABC transporter 0.0015 0.004 0.0018
Toxoplasma gondii ABC transporter family protein 0.0015 0.004 0.0182
Loa Loa (eye worm) multidrug resistance-associated protein 0.0029 0.0223 0.0214
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0199 0.0235
Toxoplasma gondii thioredoxin reductase 0.0086 0.0995 1
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0183 0.2289 0.2278
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.2411 0.422
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0068 0.0131
Leishmania major protein kinase, putative 0.0027 0.0199 0.0408
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0239 0.0224
Entamoeba histolytica acyl-CoA synthetase, putative 0.0017 0.0068 0.0075
Trypanosoma cruzi multidrug resistance protein E, putative 0.0043 0.0418 0.0874
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0068 0.0118
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0199 0.0408
Loa Loa (eye worm) histone methyltransferase 0.0016 0.0049 0.004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0197
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0197
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0044 0.0427 0.0892
Trichomonas vaginalis glucosylceramidase, putative 0.0311 0.3998 0.4872
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0024 0.0008
Loa Loa (eye worm) POT family protein 0.003 0.0233 0.0224
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0026 0.0181 0.0213
Trichomonas vaginalis ABC transporter, putative 0.0026 0.0181 0.0213
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0239 0.0224
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0049 0.0034
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0239 0.0493
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.008
Onchocerca volvulus 0.002 0.0108 0.0105
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0015 0.004 0.0078
Echinococcus granulosus nuclear factor of activated T cells 5 0.0059 0.063 0.0616
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0239 0.0493
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0239 0.0493
Loa Loa (eye worm) hypothetical protein 0.0045 0.044 0.0431
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0026 0.0188 0.0329
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0026 0.0188 0.0457
Brugia malayi Cytochrome P450 family protein 0.0045 0.0447 0.0426
Echinococcus multilocularis beta adrenergic receptor kinase 0.0014 0.0024 0.0008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0064 0.0697 0.0683
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0015 0.004 0.007
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0115 0.1067
Schistosoma mansoni ap endonuclease 0.004 0.0375 0.036
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0026 0.0188 0.0457
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0394 0.0689
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0031 0.025 0.0236
Mycobacterium ulcerans lipase LipD 0.0069 0.0757 0.1914
Onchocerca volvulus 0.0099 0.1164 0.1396
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0068 0.0045
Plasmodium vivax ABC transporter B family member 6, putative 0.0015 0.004 0.0106
Entamoeba histolytica P-glycoprotein 5, putative 0.0015 0.0033 0.0033
Toxoplasma gondii ABC transporter, putative 0.0015 0.004 0.0182
Loa Loa (eye worm) hypothetical protein 0.002 0.0108 0.0099
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0026 0.0181 0.0213
Loa Loa (eye worm) DR-78 0.0028 0.0206 0.0197
Echinococcus granulosus FTZ F1 alpha 0.0058 0.0619 0.0605
Mycobacterium ulcerans esterase/lipase LipP 0.0069 0.0757 0.1914
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0068 0.0149
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0375 0.036
Onchocerca volvulus 0.0028 0.0206 0.0225
Echinococcus granulosus gamma secretase subunit aph 1 0.0759 1 1
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0199 0.0235
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0026 0.0181 0.0166
Schistosoma mansoni agrin 0.0014 0.0022 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0014
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.0033 0.0033
Plasmodium vivax ABC transporter B family member 7, putative 0.0015 0.004 0.0106
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0043 0.0418 0.0874
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0239 0.0493
Brugia malayi beta-lactamase family protein 0.0069 0.0757 0.0737
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.8187 0.9985
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.8187 0.9985
Echinococcus granulosus ATP binding cassette sub family B 0.0015 0.004 0.0025
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.0199 0.8252
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0081 0.0059
Brugia malayi 6-phosphofructokinase 0.0079 0.09 0.0879
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0219 0.2773 0.4855
Trichomonas vaginalis phosphofructokinase, putative 0.0079 0.0892 0.1082
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0372 0.0357
Schistosoma mansoni hypothetical protein 0.0447 0.5822 0.5815
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0862 0.0848
Brugia malayi regulator of G-protein signaling egl-10 0.0014 0.0024 0.0001
Loa Loa (eye worm) hypothetical protein 0.0058 0.0619 0.061
Brugia malayi hypothetical protein 0.0014 0.0024 0.0001
Echinococcus granulosus intermediate filament protein 0.0089 0.1033 0.102
Schistosoma mansoni hypothetical protein 0.0052 0.0538 0.0524
Entamoeba histolytica acyl-CoA synthetase, putative 0.0017 0.0068 0.0075
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0081 0.016
Trichomonas vaginalis penicillin-binding protein, putative 0.0069 0.0757 0.0917
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0051 0.0144
Brugia malayi Cytochrome P450 family protein 0.0111 0.1329 0.131
Echinococcus granulosus expressed protein 0.027 0.346 0.3451
Echinococcus granulosus geminin 0.0447 0.5822 0.5815
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0862 0.0854
Loa Loa (eye worm) hypothetical protein 0.0069 0.0757 0.0748
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0026 0.0188 0.0329
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0026 0.0181 0.0166
Trichomonas vaginalis glucosylceramidase, putative 0.0311 0.3998 0.4872
Brugia malayi nuclear receptor NHR-88 0.0028 0.0206 0.0184
Schistosoma mansoni intermediate filament proteins 0.0089 0.1033 0.102
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0188 0.0386
Brugia malayi Regulator of G protein signaling domain containing protein 0.0014 0.0024 0.0001
Brugia malayi CXXC zinc finger family protein 0.0042 0.0397 0.0375
Loa Loa (eye worm) hypothetical protein 0.0078 0.0883 0.0874
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0369 0.0354
Echinococcus granulosus beta LACTamase domain containing family member 0.0069 0.0757 0.0743
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0064 0.0697 0.0683
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0239 0.0797
Onchocerca volvulus 0.0069 0.0757 0.0899
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.0033 0.0033
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0026 0.0181 0.0166
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0031 0.025 0.0236
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0014 0.0024 0.0014
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0153 0.0179
Echinococcus granulosus survival motor neuron protein 1 0.0486 0.6342 0.6336
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0027 0.0199 0.0184
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0026 0.0188 0.0329
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0043 0.0418 0.0874
Schistosoma mansoni ap endonuclease 0.004 0.0375 0.036
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0026 0.0188 0.0329
Schistosoma mansoni gamma-secretase subunit aph-1 0.0759 1 1
Echinococcus granulosus regulator of G protein signaling 3 0.0014 0.0024 0.0008
Toxoplasma gondii aldehyde dehydrogenase 0.0044 0.0427 0.4158
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0026 0.0181 0.0171
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0206 0.0225
Entamoeba histolytica hypothetical protein 0.0052 0.0538 0.0651
Echinococcus granulosus follistatin 0.0014 0.0022 0.0007
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.004 0.0372 0.0357
Schistosoma mansoni zinc finger protein 0.0028 0.0206 0.0191
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0139 0.1698 0.1686
Schistosoma mansoni RAR-like nuclear receptor 0.0058 0.0619 0.0605
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0015 0.004 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0757 0.1592
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0015 0.004 0.0078
Entamoeba histolytica hypothetical protein 0.0014 0.0024 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0068 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0024 0.0021
Brugia malayi phosphofructokinase 0.0079 0.0892 0.0872
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0239 0.0493
Trichomonas vaginalis glucosylceramidase, putative 0.0311 0.3998 0.4872
Loa Loa (eye worm) hypothetical protein 0.0088 0.1011 0.1003
Brugia malayi hypoxia-induced factor 1 0.0321 0.4139 0.4125
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.002 0.0108 0.0093
Loa Loa (eye worm) hypothetical protein 0.002 0.0108 0.0099
Schistosoma mansoni retinoic acid receptor RXR 0.0058 0.0619 0.0605
Trypanosoma brucei p-glycoprotein 0.0043 0.0418 0.0874
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0021 0.0122 0.4932
Brugia malayi Cytochrome P450 family protein 0.0045 0.0447 0.0426
Plasmodium falciparum ABC transporter B family member 3, putative 0.0015 0.004 0.031
Loa Loa (eye worm) hypothetical protein 0.002 0.0108 0.0099
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0026 0.0181 0.0213
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0432 0.0418
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0069 0.0757 0.0737
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.0199 0.0184
Echinococcus granulosus multidrug resistance associated protein 4 0.0028 0.0216 0.0201
Entamoeba histolytica ATP-binding cassette protein, putative 0.0043 0.0418 0.0504
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0197 0.2479 0.4339
Schistosoma mansoni multidrug resistance protein 0.0026 0.0181 0.0166
Entamoeba histolytica P-glycoprotein 6, putative 0.0015 0.004 0.0042
Echinococcus multilocularis ATP binding cassette sub family B 0.0015 0.004 0.0025
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0239 0.0797
Schistosoma mansoni hypothetical protein 0.0023 0.0142 0.0127
Brugia malayi regulator of G-protein signaling rgs-7 0.0014 0.0024 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.8187 0.9985
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0199 0.0235
Trypanosoma cruzi ISWI complex protein 0.0017 0.0064 0.0122
Trichomonas vaginalis phosphofructokinase, putative 0.0079 0.0892 0.1082
Echinococcus granulosus regulator of G protein signaling 3 0.0014 0.0024 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0058 0.0619 0.0598
Loa Loa (eye worm) thioredoxin reductase 0.0086 0.0995 0.0987
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0239 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0049 0.0034
Echinococcus multilocularis ATP binding cassette sub family B 0.0015 0.004 0.0025
Plasmodium falciparum ABC transporter B family member 7, putative 0.0015 0.004 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0199 0.0235
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0013
Mycobacterium leprae conserved hypothetical protein 0.0069 0.0757 0.185
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0026 0.0188 0.0457
Echinococcus granulosus cytochrome P450 2K1 0.0026 0.0188 0.0173
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0153 0.0179
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0058 0.0619 0.0605
Loa Loa (eye worm) cytochrome P450 family protein 0.0111 0.1329 0.1321
Loa Loa (eye worm) hypothetical protein 0.0026 0.0181 0.0171
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0206 0.0191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.8187 0.9985
Loa Loa (eye worm) hypothetical protein 0.002 0.0108 0.0099
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0619 0.0598
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0197 0.2479 0.4339
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0439 0.5713 1
Mycobacterium tuberculosis Probable reductase 0.0197 0.2479 0.4339
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0026 0.0181 0.0213
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0058 0.0619 0.0605
Schistosoma mansoni survival motor neuron protein 0.0099 0.1164 0.1151
Echinococcus multilocularis multidrug resistance protein 1 0.0026 0.0181 0.0166
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0079 0.0902 0.0888
Schistosoma mansoni thyroid hormone receptor 0.0197 0.248 0.2468
Trypanosoma brucei trypanothione reductase 0.0086 0.0995 0.2097
Onchocerca volvulus 0.0356 0.4604 0.5603
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0026 0.0188 0.0457
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0206 0.0184
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0015 0.004 0.0072
Brugia malayi conserved hypotetical protein 0.0028 0.0206 0.0184
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0375 0.0782
Mycobacterium leprae Possible regulatory protein 0.0027 0.0199 0.0409
Trichomonas vaginalis abcb9, putative 0.0026 0.0181 0.0213
Plasmodium falciparum glutathione reductase 0.0086 0.0995 1
Echinococcus multilocularis transfer RNA-Lys 0.0077 0.0866 0.0852
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0015 0.004 0.0025
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0014 0.0024 0.0008
Mycobacterium tuberculosis Probable dehydrogenase 0.0197 0.2479 0.4339
Leishmania major p-glycoprotein e 0.0043 0.0418 0.0874
Plasmodium falciparum multidrug resistance protein 1 0.0026 0.0181 0.1736
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.8187 0.9985
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0017 0.0068 0.0071
Echinococcus granulosus tar DNA binding protein 0.0076 0.0862 0.0848
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0026 0.0188 0.0457
Brugia malayi hypothetical protein 0.0486 0.6342 0.6334
Entamoeba histolytica P-glyco protein 6, putative 0.0026 0.0181 0.0213
Trypanosoma cruzi Aph-1 protein, putative 0.0296 0.3797 0.8037
Schistosoma mansoni organic anion transporter 0.002 0.0108 0.0093
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0432 0.0423
Onchocerca volvulus 0.002 0.0108 0.0105
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.009 0.0074
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0173 0.215 0.2138
Trichomonas vaginalis glucosylceramidase, putative 0.0311 0.3998 0.4872
Schistosoma mansoni nuclear receptor 0.0028 0.0206 0.0191
Leishmania major p-glycoprotein 0.0026 0.0181 0.037
Brugia malayi hypothetical protein 0.0015 0.004 0.0018
Schistosoma mansoni hypothetical protein 0.0595 0.7805 0.7802
Loa Loa (eye worm) hypothetical protein 0.0061 0.0658 0.0649
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0304 0.3916 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0619 0.061
Onchocerca volvulus Protein ultraspiracle homolog 0.0058 0.0619 0.073
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0015 0.004 0.0072
Entamoeba histolytica ABC transporter, putative 0.0043 0.0418 0.0504
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0239 0.0493
Entamoeba histolytica P-glycoprotein-2 0.0026 0.0181 0.0213
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0043 0.0418 0.0409
Echinococcus multilocularis gamma secretase subunit aph 1 0.0759 1 1
Brugia malayi sodium-independent organic anion transporter family protein 0.002 0.0108 0.0086
Brugia malayi nuclear hormone receptor family member nhr-6 0.0028 0.0206 0.0184
Trichomonas vaginalis set domain proteins, putative 0.0624 0.8199 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0014
Leishmania major pentamidine resistance protein 1 0.0043 0.0418 0.0874
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0026 0.0188 0.0329
Onchocerca volvulus Putative organic anion transporter 0.002 0.0108 0.0105
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0375 0.036
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0026 0.0181 0.0213
Trichomonas vaginalis glucosylceramidase, putative 0.0473 0.6179 0.7534
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0199 0.0408
Schistosoma mansoni transcription factor LCR-F1 0.0052 0.0538 0.0524
Schistosoma mansoni single-minded 0.0104 0.1227 0.1214
Trichomonas vaginalis glucosylceramidase, putative 0.0311 0.3998 0.4872

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1413 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 0.7375 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.2589 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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