Detailed information for compound 13496

Basic information

Technical information
  • TDR Targets ID: 13496
  • Name: Phenol
  • MW: 94.1112 | Formula: C6H6O
  • H donors: 1 H acceptors: 1 LogP: 1.57 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccccc1
  • InChi: 1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H
  • InChiKey: ISWSIDIOOBJBQZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • hydron phenoxide
  • 1336-35-2
  • 108-95-2
  • 63496-48-0
  • 73607-76-8
  • 61788-41-8
  • 14534-23-7
  • 50356-25-7
  • 8002-07-1
  • 27073-41-2
  • AIDS000352
  • Phenol homopolymer
  • Phenosmolin
  • TEA polyphenol
  • P6471_SIGMA
  • Benzenol
  • C00146
  • Hydroxybenzene
  • Phenic acid
  • Phenylic acid
  • Carbolsaeure
  • D06535
  • Liquefied phenol
  • Liquefied phenol (JP15)
  • Liquefied phenol (TN)
  • Phenol, liquefied (USP)
  • D06536
  • Phenol for disinfection
  • Phenol for disinfection (JP15)
  • Phenol for disinfection (TN)
  • Benzene, hydroxy-
  • CCRIS 504
  • Liquified Phenol
  • P9346_SIAL
  • Baker's p and s
  • AI3-01814
  • Acide carbolique [French]
  • Phenol, chlorinated
  • Phenol, chloro derivs.
  • Carbolic oil
  • Carbolsaure [German]
  • Caswell No. 649
  • EINECS 203-632-7
  • EPA Pesticide Chemical Code 064001
  • FEMA No. 3223
  • Fenol [Dutch, Polish]
  • Fenolo [Italian]
  • HSDB 113
  • Liquid phenol
  • NSC 36808
  • Phenol (or solutions with 5% or more phenol)
  • Phenol [JAN]
  • Phenol alcohol
  • Phenol solutions [UN2821] [Poison]
  • Phenol, molten [UN2312] [Poison]
  • Phenol, pure
  • Phenol, solid [UN1671] [Poison]
  • Phenole [German]
  • NCGC00091454-01
  • RCRA waste number U188
  • UN 1671 (solid)
  • UN 2312 (molten)
  • UN1671
  • UN2312
  • UN2821
  • Un 2812 (solution)
  • 185450_SIAL
  • 48556_SUPELCO
  • 48688_SUPELCO
  • c0128
  • 328111_SIAL
  • Phenic
  • P3653_SIAL
  • Monohydroxy benzene
  • CHEBI:15882
  • 46344_RIEDEL
  • Karbolsaeure
  • acide phenique
  • P1037_SIAL
  • carbolic acid
  • phenylalcohol
  • (14C)Phenol
  • Phenol, labeled with carbon-14
  • ZINC00895069
  • IPH
  • NCGC00091454-02
  • NCGC00091454-03
  • 35952_RIEDEL
  • D00033
  • Paoscle (TN)
  • Phenol (JP15/USP)
  • Phenol (TN)
  • P4682_SIAL
  • 40063_SUPELCO
  • Phenol solution
  • Acide carbolique
  • Baker's P & S liquid & Ointment
  • Baker's P and S Liquid and Ointment
  • Carbolic acid, liquid
  • Fenol
  • Fenolo
  • Izal
  • Monohydroxybenzene
  • Monophenol
  • NCI-C50124
  • NSC36808
  • Oxybenzene
  • Paoscle
  • PhOH
  • Phenol (liquid)
  • Phenol, liquefied
  • Phenol, liquid
  • Phenol, synthetic
  • Phenole
  • Phenyl alcohol
  • Phenyl hydrate
  • Phenyl hydroxide
  • Phenylic alcohol
  • Synthetic phenol
  • WLN: QR
  • P4557_SIAL
  • W322318_ALDRICH
  • 52463_FLUKA
  • 297437_SIGMA
  • Phenol-UL-14C
  • C15584
  • RCRA waste no. U188
  • Fenosmolin
  • 564796_ALDRICH
  • Phenol, polymer-bound
  • 33517_RIEDEL
  • 16016_RIEDEL
  • 77607_FLUKA
  • 16017_RIEDEL
  • 77614_FLUKA
  • 16018_RIEDEL
  • P5566_SIAL
  • EINECS 262-972-4
  • Phenol, sulfurated
  • ST5214353
  • InChI=1/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7
  • LS-476
  • AIDS-000352
  • Fenosmoline
  • 242322_SIAL
  • hydron; phenolate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase XII Starlite/ChEMBL References
Mus musculus carbonic anhydrase 15 Starlite/ChEMBL References
Homo sapiens carbonic anhydrase I Starlite/ChEMBL References
Candida albicans Involved in protection against oxidative damage Starlite/ChEMBL References
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References
Homo sapiens carbonic anhydrase IX Starlite/ChEMBL References
Homo sapiens carbonic anhydrase III, muscle specific Starlite/ChEMBL References
Homo sapiens carbonic anhydrase IV Starlite/ChEMBL References
Homo sapiens carbonic anhydrase XIV Starlite/ChEMBL References
Homo sapiens galactosidase, alpha Starlite/ChEMBL No references
Dicentrarchus labrax Carbonic anhydrase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Neospora caninum hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni carbonic anhydrase Get druggable targets OG5_127503 All targets in OG5_127503
Schistosoma japonicum ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Glycoside hydrolase, family 27 Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania infantum carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Toxoplasma gondii melibiase subfamily protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Entamoeba histolytica carbonic anhydrase, putative Get druggable targets OG5_127503 All targets in OG5_127503
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) Get druggable targets OG5_127503 All targets in OG5_127503
Leishmania donovani carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Mycobacterium ulcerans carbonic anhydrase Get druggable targets OG5_127503 All targets in OG5_127503
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127503 All targets in OG5_127503
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum expressed protein Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB Get druggable targets OG5_127503 All targets in OG5_127503
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Schistosoma japonicum Alpha-N-acetylgalactosaminidase precursor, putative Get druggable targets OG5_127620 All targets in OG5_127620
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Brugia malayi Melibiase family protein Get druggable targets OG5_127620 All targets in OG5_127620
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Candida albicans Involved in protection against oxidative damage Get druggable targets OG5_127503 All targets in OG5_127503
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Candida albicans Involved in protection against oxidative damage Get druggable targets OG5_127503 All targets in OG5_127503
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Carbonic anhydrase   309 aa 287 aa 28.6 %
Brugia malayi Carbonic anhydrase like protein 2 precursor Carbonic anhydrase   309 aa 250 aa 25.2 %
Echinococcus multilocularis carbonic anhydrase II Carbonic anhydrase   309 aa 260 aa 31.5 %
Echinococcus multilocularis carbonic anhydrase Carbonic anhydrase   309 aa 288 aa 27.8 %
Echinococcus granulosus carbonic anhydrase Carbonic anhydrase   309 aa 267 aa 29.6 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Trypanosoma brucei carbonic anhydrase-like protein carbonic anhydrase III, muscle specific 260 aa 261 aa 26.1 %
Trypanosoma brucei carbonic anhydrase-like protein carbonic anhydrase I 261 aa 281 aa 25.3 %
Trypanosoma cruzi carbonic anhydrase-like protein, putative carbonic anhydrase 15 324 aa 263 aa 27.8 %
Echinococcus multilocularis carbonic anhydrase Carbonic anhydrase   309 aa 248 aa 24.6 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase IV 312 aa 270 aa 26.7 %
Trypanosoma cruzi carbonic anhydrase-like protein, putative carbonic anhydrase XII 354 aa 295 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0019
Brugia malayi Glutamate receptor 2 precursor 0.0074 0.0227 0.0614
Echinococcus granulosus neutral amino acid transporter 0.0251 0.097 0.0983
Onchocerca volvulus Phospholipase A2 homolog 0.0432 0.1734 0.4114
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.01 0.0268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0089 0.0237
Echinococcus multilocularis Excitatory amino acid transporter 0.0251 0.097 0.0969
Plasmodium vivax glutathione reductase, putative 0.0095 0.0315 0.6773
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0076 0.0181
Brugia malayi Cytochrome P450 family protein 0.0027 0.0029 0.0077
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.0315 0.0314
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0436 0.0745
Entamoeba histolytica hypothetical protein, conserved 0.0044 0.01 0.0924
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0053 0.031
Toxoplasma gondii cytochrome p450 superfamily protein 0.0027 0.0029 0.0192
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0185 0.0498
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0027 0.0029 0.0192
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1031 0.4253 0.7292
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0027 0.0029 0.0192
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0054 0.0318
Loa Loa (eye worm) hypothetical protein 0.0302 0.1186 0.321
Echinococcus multilocularis Niemann Pick C1 protein 0.0287 0.1122 0.1121
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0086 0.0279 0.5978
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0216 0.0824 0.1805
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0089 0.0088
Onchocerca volvulus 0.0033 0.0054 0.0125
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0004 0.0016
Onchocerca volvulus 0.0024 0.0016 0.0035
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0073 0.0432
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0139 0.0138
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0004 0.0018
Echinococcus multilocularis expressed conserved protein 0.0189 0.0708 0.0707
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0004 0.0009
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0017 0.0028
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0204 0.0773 0.1323
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0161 0.1329
Loa Loa (eye worm) hypothetical protein 0.0086 0.0278 0.075
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0089 0.0237
Onchocerca volvulus 0.0021 0.0004 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0442 0.2653
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0045 0.0118
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0073 0.0073
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1075 0.4438 0.4437
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0078 0.0131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0054 0.0127
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0004 0.0018
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0078 0.0131
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0044 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0054 0.0127
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0068 0.0183
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0054 0.0547
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0004 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0442 0.2653
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0228 0.1367
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0078 0.0078
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0228 0.1367
Echinococcus granulosus glutamate NMDA receptor subunit 0.0032 0.0051 0.005
Brugia malayi 6-phosphofructokinase 0.0216 0.0824 0.2229
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0038 0.0077 0.0076
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0053 0.035
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0073 0.0432
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0017 0.0044
Echinococcus multilocularis pyruvate kinase 0.0033 0.0053 0.0052
Plasmodium falciparum glutathione reductase 0.0095 0.0315 0.2636
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0416 0.0988
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0004 0.0003
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.052 0.2102 0.3603
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0053 0.031
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0416 0.1664 0.4505
Entamoeba histolytica cysteine protease, putative 0.0033 0.0054 0.0491
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.01 0.0268
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0004 0.0018
Brugia malayi hypothetical protein 0.0044 0.01 0.0268
Schistosoma mansoni ATP-binding cassette transporter 0.0032 0.0051 0.0085
Brugia malayi hypothetical protein 0.0153 0.0558 0.1508
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0302 0.1186 0.2031
Giardia lamblia Pyruvate kinase 0.0033 0.0053 0.2188
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0073 0.0173
Loa Loa (eye worm) MBCTL1 0.0053 0.0139 0.0374
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0073 0.0432
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0004 0.0016
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0089 0.0088
Trichomonas vaginalis ap endonuclease, putative 0.0077 0.0237 0.0563
Brugia malayi nuclear receptor RXR 0.0022 0.0007 0.0016
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0053 0.0352
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.0228 0.212
Schistosoma mansoni hypothetical protein 0.0083 0.0265 0.0452
Leishmania major carbonic anhydrase-like protein 0.0416 0.1664 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.047 0.1892 0.5123
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0161 0.0382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0442 0.2653
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0161 0.0382
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0044 0.0103
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0251 0.097 0.23
Echinococcus granulosus Excitatory amino acid transporter 0.0251 0.097 0.0983
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0077 0.0513
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0078 0.0208
Echinococcus granulosus tissue type plasminogen activator 0.0024 0.0016 0.0015
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.0315 0.2137
Loa Loa (eye worm) hypothetical protein 0.0083 0.0266 0.0719
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0077 0.0237 0.1976
Loa Loa (eye worm) cytochrome P450 0.0027 0.0029 0.0077
Brugia malayi Cytochrome P450 family protein 0.0036 0.0068 0.0183
Echinococcus granulosus collagen alpha 1VII chain 0.0044 0.01 0.01
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0054 0.1092
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0228 0.1367
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0054 0.009
Leishmania major cytochrome p450-like protein 0.0036 0.0068 0.0405
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0442 0.2653
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.013 0.0464 0.3147
Entamoeba histolytica hypothetical protein, conserved 0.0044 0.01 0.0924
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0054 0.0127
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0099 0.0592
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0054 0.0143
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0377
Schistosoma mansoni ap endonuclease 0.0077 0.0237 0.0405
Echinococcus multilocularis glutamate receptor 2 0.0083 0.0263 0.0262
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0027 0.0029 0.0192
Loa Loa (eye worm) glutathione reductase 0.0095 0.0315 0.0852
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0251 0.097 0.1661
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0027 0.0029 0.0192
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.01 0.0268
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0416 0.1664 1
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0078 0.0131
Echinococcus granulosus dnaJ subfamily B 0.0813 0.3336 0.3383
Treponema pallidum glutamate transporter 0.0111 0.0383 0.0837
Echinococcus granulosus sodium:dicarboxylate symporter 0.0251 0.097 0.0983
Echinococcus multilocularis expressed protein 0.0751 0.3074 0.3074
Schistosoma mansoni slit 0.0024 0.0017 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0442 0.2653
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0185 0.0696 0.1191
Loa Loa (eye worm) hypothetical protein 0.0082 0.026 0.0702
Onchocerca volvulus Phospholipase A2 homolog 0.0091 0.0298 0.0706
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0237
Echinococcus granulosus chromobox protein 1 0.0068 0.0202 0.0204
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0089 0.0089
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0041 0.0086 0.0086
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0068 0.0405
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0077 0.0237 0.024
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0416 0.1664 0.2851
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0202 0.048
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0302 0.1186 0.321
Onchocerca volvulus 0.01 0.0336 0.0794
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0004 0.0018
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0004 0.0018
Entamoeba histolytica peptidase, C54 family 0.0023 0.0011 0.0094
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0059 0.0164 0.1359
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0004 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.013 0.0464 0.0463
Loa Loa (eye worm) 6-phosphofructokinase 0.0216 0.0824 0.2229
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0077 0.0237 0.0236
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0024 0.0024
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0161 0.0382
Schistosoma mansoni hypothetical protein 0.0083 0.0265 0.0452
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0073 0.0073
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0008 0.0064
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0268
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0442 0.2653
Plasmodium falciparum pyruvate kinase 0.0033 0.0053 0.0414
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0078 0.0208
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0004 0.0007
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0027 0.0029 0.0192
Brugia malayi RNA binding protein 0.0064 0.0185 0.0498
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0089 0.0208
Loa Loa (eye worm) hypothetical protein 0.0476 0.1918 0.5193
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.04 0.0399
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0044 0.0103
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0077 0.0237 1
Entamoeba histolytica hypothetical protein 0.0039 0.0078 0.0714
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0078 0.0077
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0147 0.0146
Schistosoma mansoni 6-phosphofructokinase 0.0216 0.0824 0.1411
Echinococcus granulosus glutamate receptor 4 0.0042 0.0092 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0089 0.0237
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0128 0.0863
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0053 0.048
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0004 0.0007
Trypanosoma brucei trypanothione reductase 0.0095 0.0315 0.189
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0089 0.0237
Brugia malayi glutathione reductase 0.0095 0.0315 0.0852
Loa Loa (eye worm) hypothetical protein 0.0047 0.0112 0.03
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0058 0.0161 0.016
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0139 0.014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0089 0.0088
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0023 0.0011 0.0027
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0078 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0076 0.0181
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0278 0.0281
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0029 0.017
Mycobacterium ulcerans hypothetical protein 0.0023 0.0011 0.0067
Echinococcus granulosus cathepsin l1 0.0022 0.0008 0.0007
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0077 0.0205
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0054 0.0318
Treponema pallidum hypothetical protein 0.0044 0.01 0.0217
Onchocerca volvulus 0.0044 0.01 0.0235
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0027 0.0029 0.0192
Plasmodium falciparum glutathione reductase 0.0033 0.0054 0.0425
Echinococcus granulosus Excitatory amino acid transporter 0.0251 0.097 0.0983
Echinococcus granulosus tar DNA binding protein 0.0064 0.0185 0.0186
Loa Loa (eye worm) hypothetical protein 0.0201 0.076 0.2055
Brugia malayi hypothetical protein 0.049 0.1977 0.5354
Loa Loa (eye worm) hypothetical protein 0.0058 0.0161 0.0433
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0077 0.0237 0.1421
Brugia malayi Glutamate receptor 1 precursor 0.0074 0.0227 0.0614
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0027 0.0029 0.0192
Loa Loa (eye worm) hypothetical protein 0.0091 0.0298 0.0805
Schistosoma mansoni lamin 0.0083 0.0266 0.0455
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0268
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0078 0.0208
Echinococcus multilocularis glutamate receptor 2 0.0066 0.0194 0.0193
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0089 0.0089
Echinococcus multilocularis bloom syndrome protein 0.0065 0.0187 0.0186
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0054 0.1092
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0058 0.0161 0.149
Onchocerca volvulus 0.0033 0.0054 0.0125
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0026 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0442 0.2653
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0054 0.0318
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0031 0.0045 0.0296
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0007 0.0016
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0051 0.0085
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0023 0.0011 0.0067
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0011 0.0095
Echinococcus multilocularis leukotriene A 4 hydrolase 0.025 0.0967 0.0966
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.014 0.0954
Brugia malayi Niemann-Pick C1 protein precursor 0.0201 0.076 0.2055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0128 0.0863
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0088 0.021
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0077 0.0237 0.5077
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0139 0.014
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0053 0.0123
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0824 0.1955
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0044 0.0103
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0044 0.0103
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0046 0.0045
Toxoplasma gondii microneme protein MIC2 0.0044 0.01 0.0673
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0183 0.0185
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0216 0.0824 0.5594
Echinococcus multilocularis Protein lozenge 0.0054 0.0143 0.0142
Echinococcus granulosus cathepsin l1 0.0033 0.0054 0.0053
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0078 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0073 0.0173
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0054 0.0318
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.014 0.0947
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0016 0.0088
Loa Loa (eye worm) hypothetical protein 0.0039 0.0078 0.0208
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0237
Toxoplasma gondii 6-phosphofructokinase 0.0058 0.0161 0.1086
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0377
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.04 0.0404
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0053 0.014
Schistosoma mansoni hypothetical protein 0.0024 0.0016 0.0025
Echinococcus multilocularis microtubule associated protein 2 0.1407 0.5833 0.5832
Schistosoma mansoni hypothetical protein 0.0064 0.0183 0.0313
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0077 0.0237 0.064
Echinococcus multilocularis jumonji domain containing 1A 0.0031 0.0045 0.0044
Echinococcus granulosus neutral amino acid transporter A 0.0251 0.097 0.0983
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0089 0.0237
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0111 0.0383 0.0655
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0078 0.0131
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0044 0.0103
Echinococcus granulosus carbonic anhydrase 0.0302 0.1186 0.1202
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0201 0.076 0.7075
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0053 0.0123
Loa Loa (eye worm) leukotriene A4 hydrolase 0.025 0.0967 0.2617
Brugia malayi nuclear receptor NHR-88 0.0041 0.0089 0.0237
Chlamydia trachomatis endonuclease IV 0.0086 0.0279 0.2464
Loa Loa (eye worm) glutamate receptor 2 0.0032 0.0051 0.0135
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0089 0.0088
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0112 0.0112
Schistosoma mansoni protein phosphatase 2C 0.0031 0.0045 0.0075
Trypanosoma cruzi cysteine peptidase, putative 0.0125 0.0442 0.2653
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0004 0.0025
Leishmania major hypothetical protein, conserved 0.0031 0.0045 0.0262
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0051 0.0085
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0078 0.0078
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0156 0.0573 0.3887
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0183 0.0494
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0004 0.0018
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0237
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0086 0.0279 0.0752
Plasmodium falciparum thioredoxin reductase 0.0033 0.0054 0.0425
Echinococcus multilocularis neutral amino acid transporter A 0.0251 0.097 0.0969
Mycobacterium ulcerans carbonic anhydrase 0.0119 0.0416 0.2823
Onchocerca volvulus 0.0142 0.0511 0.121
Schistosoma mansoni ap endonuclease 0.0077 0.0237 0.0405
Echinococcus multilocularis pikachurin 0.0024 0.0017 0.0016
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0078 0.0078
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0027 0.0029 0.017
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0011 0.006
Schistosoma mansoni hypothetical protein 0.0555 0.2251 0.3859
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0054 0.0422
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0004 0.0016
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0053 0.0352
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0302 0.1186 0.321
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0078 0.0077
Toxoplasma gondii hypothetical protein 0.0302 0.1186 0.8056
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0262 0.0448
Echinococcus multilocularis lamin dm0 0.0083 0.0266 0.0265
Schistosoma mansoni hypothetical protein 0.01 0.0336 0.0574
Trichomonas vaginalis ap endonuclease, putative 0.0077 0.0237 0.0563
Echinococcus granulosus tumor protein p63 0.0682 0.2786 0.2825
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0216 0.1464
Loa Loa (eye worm) hypothetical protein 0.0153 0.0558 0.1508
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0004 0.0005
Schistosoma mansoni thyroid hormone receptor 0.0167 0.0618 0.1058
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0054 0.0318
Loa Loa (eye worm) CUTiclin-Like family member 0.0044 0.01 0.0268
Echinococcus multilocularis cysteine protease 0.0033 0.0054 0.0053
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0089 0.0088
Echinococcus multilocularis glutamate receptor 2 0.0074 0.0227 0.0226
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0089 0.015
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0027 0.0029 0.017
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0027 0.0029 0.0192
Schistosoma mansoni coup transcription factor 0.0041 0.0089 0.015
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0078 0.0077
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0027 0.0029 0.0192
Onchocerca volvulus 0.0044 0.01 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0089 0.0237
Onchocerca volvulus 0.0153 0.0558 0.1322
Brugia malayi TAR-binding protein 0.0064 0.0185 0.0498
Echinococcus multilocularis tumor protein p63 0.0682 0.2786 0.2785
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0124 0.0436 0.0435
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0027 0.0029 0.0192
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0027 0.0029 0.0192
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0078 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0054 0.0127
Echinococcus granulosus glutamate receptor subunit protein glur 0.0058 0.0161 0.0163
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0161 0.0382
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0027 0.0029 0.0192
Brugia malayi Cathepsin L-like precursor 0.0033 0.0054 0.0143
Treponema pallidum NADH oxidase 0.0033 0.0054 0.0116
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0078 0.0208
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0216 0.1464
Loa Loa (eye worm) hypothetical protein 0.0046 0.0108 0.0291
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0073 0.0072
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0027 0.0029 0.0192
Schistosoma mansoni cpg binding protein 0.009 0.0294 0.0503
Echinococcus granulosus JmjC domain containing protein 4 0.0031 0.0045 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0054 0.0127
Schistosoma mansoni glutamate receptor NMDA 0.0041 0.0086 0.0146
Onchocerca volvulus 0.0047 0.0112 0.0263
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.0065 0.0065
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0111 0.0383 0.0382
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0142 0.0511 0.0874
Brugia malayi steroid hormone receptor 0.0041 0.0089 0.0237
Brugia malayi Cathepsin L-like precursor 0.0033 0.0054 0.0143
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0054 0.0143
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.0315 0.189
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0054 0.0318
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0027 0.0029 0.0192
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0205
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.014 0.2967
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0044
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0268
Entamoeba histolytica peptidase, C54 family 0.0023 0.0011 0.0094
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0045 0.0118
Onchocerca volvulus 0.0083 0.0266 0.063
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0089 0.015
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0078 0.0208
Brugia malayi Pre-SET motif family protein 0.013 0.0464 0.1254
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0268
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0046 0.0122
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0139 0.0374
Echinococcus granulosus excitatory amino acid transporter 2 0.0251 0.097 0.0983
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0053 0.014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0089 0.0237
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0268
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.01 0.0268
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.0445 0.0444
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0004 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0054 0.0127
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0026 0.0168
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0216 0.0583
Loa Loa (eye worm) hypothetical protein 0.0146 0.053 0.1434
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0241 0.0929 0.8658
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0112 0.03
Trichomonas vaginalis rotamase, putative 0.0033 0.0053 0.0125
Schistosoma mansoni hypothetical protein 0.0083 0.0265 0.0452
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0016
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0183 0.0182
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0004 0.0018
Plasmodium falciparum cysteine protease ATG4, putative 0.0023 0.0011 0.0062
Onchocerca volvulus 0.0041 0.0089 0.0208
Plasmodium vivax SET domain protein, putative 0.013 0.0464 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.0016 0.004
Schistosoma mansoni carbonic anhydrase 0.0275 0.1073 0.1839
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0054 0.036
Schistosoma mansoni hypothetical protein 0.0083 0.0265 0.0452
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0073 0.0073
Echinococcus multilocularis slit 2 protein 0.0024 0.0017 0.0016
Brugia malayi cytochrome P450 0.0027 0.0029 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0078 0.0184
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.014 0.1155
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0004 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0161 0.0382
Schistosoma mansoni 6-phosphofructokinase 0.0216 0.0824 0.1411
Trypanosoma cruzi major cysteine proteinase, putative 0.0098 0.0329 0.1975
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0078 0.0184
Loa Loa (eye worm) hypothetical protein 0.0042 0.0092 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0029 0.0069
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0004 0.0007
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0054 0.0143
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.1864 0.1863
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0336 0.0907
Echinococcus multilocularis carbonic anhydrase 0.0302 0.1186 0.1185
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0054 0.0318
Brugia malayi von Willebrand Factor 0.0044 0.01 0.0268
Schistosoma mansoni glutamate receptor NMDA 0.0032 0.0051 0.0085
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0099 0.0592
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0147 0.0149
Echinococcus granulosus cysteine protease atg4b 0.0058 0.0161 0.0162
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0275 0.1073 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0089 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0089 0.0237
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0128 0.0863
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0004 0.0025
Loa Loa (eye worm) RecQ helicase 0.0065 0.0187 0.0505
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0089 0.0088
Onchocerca volvulus 0.0033 0.0054 0.0125
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0241 0.0929 0.6313
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0004 0.0018
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0078 0.0208
Schistosoma mansoni phd/f-box containing protein 0.0031 0.0045 0.0075
Onchocerca volvulus 0.0021 0.0004 0.0006
Mycobacterium tuberculosis Probable reductase 0.0217 0.0828 0.5621
Echinococcus multilocularis glutamate receptor 4 0.0042 0.0092 0.0091
Brugia malayi Cathepsin L-like precursor 0.0033 0.0054 0.0143
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0004 0.0018
Toxoplasma gondii aldehyde dehydrogenase 0.037 0.1472 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0237
Schistosoma mansoni cytochrome P450 0.0027 0.0029 0.0049
Echinococcus multilocularis neutral amino acid transporter A 0.0251 0.097 0.0969
Onchocerca volvulus 0.0044 0.01 0.0235
Loa Loa (eye worm) hypothetical protein 0.0201 0.0762 0.2062
Toxoplasma gondii thioredoxin reductase 0.0095 0.0315 0.2137
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0112 0.019
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0216 0.1464
Echinococcus granulosus Niemann Pick C1 protein 0.0287 0.1122 0.1137
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0054 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0089 0.0237
Brugia malayi Melibiase family protein 0.0082 0.0262 0.0708
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0054 0.0318
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0237
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0089 0.0237
Plasmodium vivax JmjC domain containing protein 0.0031 0.0045 0.0887
Echinococcus granulosus glutamate receptor 1 0.0042 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0019
Loa Loa (eye worm) cytochrome P450 family protein 0.0133 0.0473 0.128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0004 0.0018
Echinococcus granulosus muscleblind protein 0.0146 0.053 0.0537
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0302 0.1186 0.321
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0044 0.0103
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0073 0.0072
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0268
Loa Loa (eye worm) hypothetical protein 0.0106 0.0359 0.097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0442 0.2653
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0089 0.015
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0085 0.0084
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0111 0.0383 0.0655
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0054 0.0127
Brugia malayi EGF-like domain containing protein 0.0024 0.0017 0.0044
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0054 0.0316
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0183 0.0494
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0416 0.1664 1
Loa Loa (eye worm) cysteine protease 0.0033 0.0054 0.0143
Echinococcus granulosus 6 phosphofructokinase 0.0216 0.0824 0.0834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0054 0.0127
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0053 0.0311
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0017 0.0044
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0031 0.0045 0.0296
Schistosoma mansoni cellular tumor antigen P53 0.01 0.0336 0.0574
Loa Loa (eye worm) hypothetical protein 0.0039 0.0078 0.0208
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0054 0.036
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0089 0.0237
Schistosoma mansoni carbonic anhydrase-related 0.0302 0.1186 0.2031
Leishmania major pyruvate kinase 0.0033 0.0053 0.0311
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0073 0.0123
Plasmodium falciparum JmjC domain-containing protein, putative 0.0031 0.0045 0.0345
Brugia malayi hypothetical protein 0.0431 0.173 0.4684
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0073 0.0123
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0082 0.0552
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0044 0.01 0.0099
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0044 0.01 0.0815
Schistosoma mansoni patched 1 0.0086 0.0278 0.0474
Schistosoma mansoni jumonji domain containing protein 0.0115 0.04 0.0684
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0083 0.0263 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0278 0.0659
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0027 0.0029 0.017
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0053 0.014
Echinococcus granulosus excitatory amino acid transporter 3 0.0251 0.097 0.0983
Onchocerca volvulus 0.0044 0.01 0.0235
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.013 0.0464 0.0793
Leishmania major cathepsin L-like protease 0.0033 0.0054 0.0316
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0011 0.006
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0054 0.0318
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0268
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.013 0.0464 0.0793
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0004 0.0018
Schistosoma mansoni jumonji domain containing protein 0.0031 0.0045 0.0075
Leishmania major hypothetical protein, conserved 0.0024 0.0016 0.0088
Loa Loa (eye worm) jmjC domain-containing protein 0.012 0.042 0.1135
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0053 0.0311
Echinococcus multilocularis pyruvate kinase 0.0026 0.0024 0.0023
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0044 0.01 0.0268
Echinococcus multilocularis cysteine protease 0.0033 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0687 0.2805 0.7596
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0006 0.0014
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0056 0.0148
Echinococcus granulosus GPCR family 2 0.0064 0.0183 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0078 0.0131
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0016
Echinococcus multilocularis protein dispatched 1 0.0098 0.0329 0.0328
Loa Loa (eye worm) hypothetical protein 0.0038 0.0076 0.0204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0054 0.0127
Brugia malayi hypothetical protein 0.0022 0.0007 0.0016
Echinococcus multilocularis cpg binding protein 0.009 0.0294 0.0293
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0041 0.0086 0.0085
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0038 0.0077 0.0077
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0027 0.0029 0.0192
Trichomonas vaginalis DNA helicase recq1, putative 0.0065 0.0187 0.0445
Brugia malayi cathepsin L-like precursor 0.0022 0.0008 0.0019
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0139 0.0236
Loa Loa (eye worm) hypothetical protein 0.0072 0.0216 0.0583
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0046 0.0046
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0078 0.0208
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0217 0.0828 0.5621
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0083 0.0263 0.0266
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0185 0.0315
Schistosoma mansoni hypothetical protein 0.0064 0.0183 0.0313
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.0824 0.7672
Mycobacterium ulcerans epimerase 0.0023 0.0011 0.0067
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0097 0.0096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0054 0.0127
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0089 0.0088
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0073 0.0432
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0029 0.017
Leishmania major pyruvate kinase 0.0033 0.0053 0.0311
Plasmodium vivax vivapain-2 0.0033 0.0054 0.1085
Echinococcus granulosus lamin dm0 0.0083 0.0266 0.0269
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0078 0.0078
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.025 0.0967 0.1656
Echinococcus granulosus expressed protein 0.0033 0.0056 0.0056
Brugia malayi hypothetical protein 0.0039 0.0078 0.0208
Brugia malayi hypothetical protein 0.0264 0.1024 0.2772
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0027 0.0029 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0089 0.0237
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0216 0.1295
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0023 0.0011 0.0024
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0077 0.0237 0.1421
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0216 0.1464
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.0228 0.0227
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0027 0.0029 0.0192
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0054 0.0127
Echinococcus granulosus histone lysine methyltransferase setb 0.013 0.0464 0.0469
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0054 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0054 0.0127
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0436 0.1179
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0011 0.0093
Echinococcus multilocularis muscleblind protein 0.0146 0.053 0.0529
Mycobacterium leprae putative cytochrome p450 0.0027 0.0029 0.0264
Loa Loa (eye worm) hypothetical protein 0.0072 0.0216 0.0583
Echinococcus multilocularis excitatory amino acid transporter 2 0.0251 0.097 0.0969
Echinococcus granulosus intermediate filament protein 0.0083 0.0266 0.0269
Entamoeba histolytica recQ family helicase, putative 0.0044 0.0099 0.0918
Treponema pallidum 76K protein 0.0044 0.01 0.0217
Brugia malayi follicle stimulating hormone receptor 0.047 0.1892 0.5123
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0054 0.0053
Mycobacterium ulcerans 6-phosphofructokinase 0.0216 0.0824 0.5594
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0078 0.0131
Loa Loa (eye worm) 6-phosphofructokinase 0.0216 0.0824 0.2229
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0078 0.0184
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0161 0.3414
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0004 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0054 0.0127
Brugia malayi Muscleblind-like protein 0.0146 0.053 0.1434
Echinococcus multilocularis GPCR, family 2 0.0064 0.0183 0.0182
Loa Loa (eye worm) phosphofructokinase 0.0216 0.0824 0.2229
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0216 0.2008
Echinococcus multilocularis musashi 0.0083 0.0266 0.0265
Schistosoma mansoni hypothetical protein 0.0064 0.0183 0.0313
Schistosoma mansoni jumonji/arid domain-containing protein 0.012 0.042 0.0719
Loa Loa (eye worm) hypothetical protein 0.0033 0.0053 0.014
Schistosoma mansoni chromobox protein 0.0068 0.0202 0.0345
Schistosoma mansoni hypothetical protein 0.0044 0.01 0.017
Leishmania major cytochrome p450-like protein 0.0027 0.0029 0.017
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0027 0.0029 0.0192
Schistosoma mansoni cpg binding protein 0.009 0.0294 0.0503
Loa Loa (eye worm) hypothetical protein 0.0039 0.0078 0.0208
Loa Loa (eye worm) runx1 0.0054 0.0143 0.0385
Onchocerca volvulus 0.003 0.0041 0.0096
Brugia malayi Zona pellucida-like domain containing protein 0.0044 0.01 0.0268
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0004 0.0018
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0054 0.0547
Loa Loa (eye worm) carbonic anhydrase 3 0.0416 0.1664 0.4505
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0027
Schistosoma mansoni hypothetical protein 0.0027 0.0029 0.0049
Echinococcus granulosus cytochrome P450 2K1 0.0027 0.0029 0.0029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0216 0.2008
Brugia malayi PXA domain containing protein 0.0039 0.0078 0.0208
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0436 0.0745
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0054 0.0425
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.0315 0.0852
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0086 0.0279 0.2327
Echinococcus granulosus Peptidase C54 0.0058 0.0161 0.0162
Echinococcus granulosus leukotriene A 4 hydrolase 0.025 0.0967 0.098
Loa Loa (eye worm) hypothetical protein 0.0432 0.1734 0.4695
Onchocerca volvulus 0.0021 0.0004 0.0006
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0041 0.0086 0.0085
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0017 0.0044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0089 0.0237
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0416 0.1664 0.4505
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0216 0.0583
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0089 0.015
Schistosoma mansoni survival motor neuron protein 0.01 0.0336 0.0574
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0217 0.0828 0.5621
Echinococcus granulosus glutamate receptor 2 0.0083 0.0263 0.0266
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0031 0.0045 0.0262
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0045 0.0262
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0161 0.0382
Toxoplasma gondii histone lysine methyltransferase SET1 0.0166 0.0614 0.4171
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0431 0.173 0.4684
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.0445 0.045
Schistosoma mansoni carbonic anhydrase-related 0.0302 0.1186 0.2031
Echinococcus granulosus Niemann Pick C1 protein 0.0201 0.076 0.0769
Brugia malayi Cathepsin L-like precursor 0.0033 0.0054 0.0143
Echinococcus granulosus expressed protein 0.0751 0.3074 0.3117
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0089 0.015
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0054 0.0053
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0077 0.0513
Echinococcus granulosus lysine specific demethylase 5A 0.012 0.042 0.0425
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.013 0.0464 0.0463
Mycobacterium ulcerans aldehyde dehydrogenase 0.037 0.1472 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0078 0.0077
Loa Loa (eye worm) hypothetical protein 0.0431 0.173 0.4684
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0024 0.0023
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0302 0.1186 0.321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0054 0.0127
Chlamydia trachomatis glutamate symporter 0.0251 0.097 1
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0124 0.0436 0.0441
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0054 0.0318
Echinococcus granulosus pyruvate kinase 0.0033 0.0053 0.0052
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0077 0.0237 0.1421
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0076 0.0178
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0004 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0089 0.0237
Echinococcus multilocularis survival motor neuron protein 1 0.049 0.1977 0.1976
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.014 0.0947
Leishmania major cytochrome p450-like protein 0.0027 0.0029 0.017
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0017 0.0044
Onchocerca volvulus 0.0033 0.0054 0.0125
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0078 0.0077
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0006 0.0014
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0103 0.0277
Chlamydia trachomatis neutral amino acid transporter 0.0111 0.0383 0.3599
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0124 0.0436 0.0441
Loa Loa (eye worm) hypothetical protein 0.01 0.0336 0.0906
Echinococcus multilocularis muscleblind protein 1 0.0146 0.053 0.0529
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0024 0.0023
Echinococcus granulosus slit 2 protein 0.0024 0.0017 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0161 0.0382
Mycobacterium tuberculosis Probable oxidoreductase 0.0241 0.0929 0.6313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0089 0.0237
Loa Loa (eye worm) RNA binding protein 0.0064 0.0185 0.0498
Brugia malayi jmjC domain containing protein 0.0031 0.0045 0.0118
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0026 0.0186
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.01 0.0268
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0044 0.0103
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0054 0.0125
Echinococcus multilocularis tissue type plasminogen activator 0.0024 0.0016 0.0015
Leishmania major cathepsin L-like protease 0.0125 0.0442 0.2653
Loa Loa (eye worm) hypothetical protein 0.0086 0.0279 0.0752
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0054 0.0127
Echinococcus granulosus excitatory amino acid transporter 2 0.0251 0.097 0.0983
Echinococcus multilocularis JmjC domain containing protein 4 0.0031 0.0045 0.0044
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0058 0.0161 0.0382
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0044 0.01 0.0238
Brugia malayi exodeoxyribonuclease III family protein 0.0077 0.0237 0.064
Loa Loa (eye worm) hypothetical protein 0.0042 0.0092 0.0247
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0045 0.0118
Echinococcus granulosus voltage dependent calcium channel subunit 0.2364 0.9859 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0078 0.0184
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0216 0.0583
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0216 0.1464
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0089 0.0089
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0077 0.0205
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0058 0.0161 0.035
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0017 0.0028
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0216 0.1295
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0024 0.0016 0.026
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.037 0.1472 0.1471
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0054 0.0127
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0044 0.01 0.0268
Toxoplasma gondii cathepsin CPL 0.0033 0.0054 0.0358
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0011 0.0067
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0089 0.0237
Echinococcus multilocularis 0.0027 0.0029 0.0028
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.01 0.0268
Echinococcus granulosus pyruvate kinase 0.0033 0.0053 0.0052
Echinococcus granulosus chromobox protein 1 0.0068 0.0202 0.0204
Brugia malayi ecdysteroid receptor 0.0041 0.0089 0.0237
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0053 0.1065
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0044
Schistosoma mansoni hypothetical protein 0.0299 0.1174 0.2012
Echinococcus multilocularis carbonic anhydrase 0.0302 0.1186 0.1185
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.0228 0.0616
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0029 0.0069
Onchocerca volvulus 0.01 0.0336 0.0795
Loa Loa (eye worm) hypothetical protein 0.0039 0.0078 0.021
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0041 0.0086 0.0086
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.0228 0.0616
Onchocerca volvulus 0.0033 0.0054 0.0125
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0004 0.0018
Brugia malayi Thioredoxin reductase 0.0095 0.0315 0.0852
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0054 0.0318
Brugia malayi mbt repeat family protein 0.0047 0.0112 0.03
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0377
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0053 0.0311
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0007 0.0016
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0044 0.01 0.0815
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0004 0.0018
Brugia malayi mbt repeat family protein 0.0047 0.0112 0.03
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0054 0.0128
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.01 0.0268
Echinococcus granulosus jumonji domain containing 1A 0.0031 0.0045 0.0044
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0078 0.0131
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0078 0.0131
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0078 0.0131
Onchocerca volvulus 0.0085 0.0274 0.0648
Onchocerca volvulus 0.0044 0.01 0.0235
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0054 0.0318
Toxoplasma gondii kringle domain-containing protein 0.0024 0.0016 0.01
Loa Loa (eye worm) hypothetical protein 0.0033 0.0054 0.0143
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0027 0.0029 0.0192
Loa Loa (eye worm) fibroinase 0.0033 0.0054 0.0143
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0054 0.0091
Echinococcus multilocularis excitatory amino acid transporter 3 0.0251 0.097 0.0969
Echinococcus multilocularis pyruvate kinase 0.0033 0.0053 0.0052
Brugia malayi jmjC domain containing protein 0.0115 0.04 0.108
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0185 0.0498
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0377
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0078 0.0184
Entamoeba histolytica peptidase, C54 family 0.0058 0.0161 0.149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0054 0.0127
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0073 0.3043
Schistosoma mansoni hypothetical protein 0.0813 0.3336 0.5719
Trypanosoma cruzi cysteine peptidase, putative 0.0125 0.0442 0.2653
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0128 0.0863
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0053 0.0352
Onchocerca volvulus 0.0072 0.0216 0.0511
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0053 0.0482
Brugia malayi jmjC domain containing protein 0.0031 0.0045 0.0118
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0078 0.0077
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0027 0.0029 0.0192
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2364 0.9859 0.9859
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0089 0.015
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0004 0.0016
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0058 0.0161 0.6761
Loa Loa (eye worm) hypothetical protein 0.0042 0.0092 0.0247
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0054 0.0491
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0027 0.0029 0.0192
Brugia malayi hypothetical protein 0.0115 0.0399 0.1078
Echinococcus multilocularis carbonic anhydrase 0.0302 0.1186 0.1185
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0027 0.0029 0.0192
Brugia malayi Heterochromatin protein 1 0.0068 0.0202 0.0545
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0054 0.036
Echinococcus granulosus lysine specific demethylase 6a 0.0031 0.0045 0.0044
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0017 0.0044
Schistosoma mansoni hypothetical protein 0.0138 0.0494 0.0846
Onchocerca volvulus 0.0021 0.0004 0.0006
Brugia malayi PXA domain containing protein 0.0039 0.0078 0.0208
Brugia malayi phosphofructokinase 0.0216 0.0824 0.2229
Onchocerca volvulus 0.0022 0.0008 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0089 0.0237
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0044 0.01 0.0673
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0004 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0011 0.006
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0161 0.3414
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0053 0.0125
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0044 0.01 0.2094
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0078 0.0077
Echinococcus granulosus carbonic anhydrase II 0.0416 0.1664 0.1686
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0054 0.0318
Loa Loa (eye worm) oxidoreductase 0.0021 0.0004 0.0007
Leishmania major cathepsin L-like protease 0.0033 0.0054 0.0316
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0216 0.2008
Loa Loa (eye worm) hypothetical protein 0.049 0.1977 0.5354
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0004 0.0018
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0054 0.0422
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0302 0.1186 0.321
Brugia malayi hypothetical protein 0.0039 0.0078 0.0208
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0026 0.0149
Brugia malayi hypothetical protein 0.0026 0.0026 0.0067
Schistosoma mansoni rotamase 0.0033 0.0056 0.0094
Loa Loa (eye worm) hypothetical protein 0.0039 0.0078 0.021
Loa Loa (eye worm) hypothetical protein 0.013 0.0464 0.1254
Echinococcus multilocularis dnaJ subfamily B 0.0813 0.3336 0.3336
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0089 0.0089
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0139 0.0138
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0183 0.0494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0054 0.0127
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0077 0.0237 0.1607
Echinococcus multilocularis lamin 0.0083 0.0266 0.0265
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0004 0.0018
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0053 0.0125
Leishmania major trypanothione reductase 0.0095 0.0315 0.189
Schistosoma mansoni serine-rich repeat protein 0.0555 0.2251 0.3859
Echinococcus granulosus geminin 0.0335 0.1325 0.1343
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0237
Entamoeba histolytica hypothetical protein 0.0044 0.01 0.0924
Schistosoma mansoni aldehyde dehydrogenase 0.037 0.1472 0.2522
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0251 0.097 0.6588
Echinococcus multilocularis excitatory amino acid transporter 2 0.0251 0.097 0.0969
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0077 0.0237 0.1421
Schistosoma mansoni aldehyde dehydrogenase 0.037 0.1472 0.2522
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0089 0.0237
Echinococcus granulosus pikachurin 0.0024 0.0017 0.0016
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0078 0.0131
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0161 0.1178
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.1864 0.1889
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0089 0.0089
Schistosoma mansoni chromobox protein 0.0068 0.0202 0.0345
Leishmania major cathepsin L-like protease 0.0033 0.0054 0.0316
Plasmodium vivax hypothetical protein, conserved 0.0044 0.01 0.2094
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1104 0.4559 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.0065 0.0064
Brugia malayi Protein kinase domain containing protein 0.0024 0.0016 0.004
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0027 0.0029 0.0192
Echinococcus granulosus microtubule associated protein 2 0.1407 0.5833 0.5915
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0185 0.0315
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0078 0.0208
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.0228 0.039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0054 0.0127
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0216 0.1464
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0068 0.0183
Mycobacterium ulcerans endonuclease IV 0.0086 0.0279 0.1888
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0054 0.0318
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0216 0.0824 0.4948
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.037 0.1472 0.8845
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0027 0.0029 0.0192
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0054 0.0316
Mycobacterium ulcerans aldehyde dehydrogenase 0.037 0.1472 1
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0112 0.019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.0762 0.2062
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0004 0.0016
Schistosoma mansoni pyruvate kinase 0.0033 0.0053 0.0089
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0109
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0898 0.3692 1
Schistosoma mansoni pyruvate kinase 0.0033 0.0053 0.0089
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0027 0.0029 0.0192
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0089 0.015
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0004 0.0003
Brugia malayi jmjC domain containing protein 0.0031 0.0045 0.0118
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0073 0.0195
Schistosoma mansoni blooms syndrome DNA helicase 0.0045 0.0105 0.0178
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0044
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0051 0.0085
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0004 0.0016
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0054 0.0053
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0089 0.0088
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0185 0.0498
Schistosoma mansoni carbonic anhydrase 0.0302 0.1186 0.2031
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0011 0.006
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0268
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0054 0.0318
Trypanosoma cruzi cruzipain precursor, putative 0.0125 0.0442 0.2653
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0216 0.2008
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0078 0.0078
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0089 0.015
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0099 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0078 0.0184
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0038 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0039 0.0078 0.0208
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.004 0.0085 0.1774
Loa Loa (eye worm) excitatory amino acid transporter 0.0251 0.097 0.2625
Brugia malayi CXXC zinc finger family protein 0.0085 0.0274 0.0739
Plasmodium falciparum cysteine repeat modular protein 1 0.0024 0.0016 0.0101
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0054 0.0127
Brugia malayi MH2 domain containing protein 0.0124 0.0436 0.1179
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0027 0.0029 0.0192
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0089 0.015
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0051 0.0085
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0004 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0054 0.0127
Echinococcus multilocularis phd:f box containing protein 0.0031 0.0045 0.0044
Echinococcus granulosus cpg binding protein 0.009 0.0294 0.0297
Echinococcus multilocularis thyroid hormone receptor alpha 0.0167 0.0618 0.0617
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.01 0.0268
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0824 0.1955
Echinococcus multilocularis Niemann Pick C1 protein 0.0201 0.076 0.0759
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0004 0.0007
Brugia malayi hypothetical protein 0.0022 0.0007 0.0016
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0216 0.0824 0.7672
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0302 0.1186 0.321
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0038 0.0077 0.0616
Entamoeba histolytica peptidase, C54 family 0.0023 0.0011 0.0094
Schistosoma mansoni cpg binding protein 0.0085 0.0274 0.0468
Echinococcus multilocularis neutral amino acid transporter A 0.0251 0.097 0.0969
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0027 0.0029 0.0192
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0078 0.0078
Echinococcus granulosus carbonic anhydrase 0.0302 0.1186 0.1202
Trypanosoma brucei carbonic anhydrase-like protein 0.0416 0.1664 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.004
Echinococcus granulosus carbonic anhydrase 0.0302 0.1186 0.1202
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0008 0.0019
Brugia malayi CHE-14 protein 0.0086 0.0278 0.075
Leishmania major cathepsin L-like protease 0.0033 0.0054 0.0316
Brugia malayi Pre-SET motif family protein 0.0898 0.3692 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0077 0.0237 0.1607
Schistosoma mansoni lozenge 0.0054 0.0143 0.0243
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0183 0.0182
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0035 0.0063 0.0062
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0089 0.0089
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0266 0.0719
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0008 0.0012
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0054 0.036
Loa Loa (eye worm) ctsf protein 0.0033 0.0054 0.0143
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0004 0.0018
Echinococcus multilocularis lysine specific demethylase 6a 0.0031 0.0045 0.0044
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0024 0.004
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0216 0.1295
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0112 0.0263
Brugia malayi Cytochrome P450 family protein 0.0133 0.0473 0.128
Echinococcus multilocularis cysteine protease atg4b 0.0058 0.0161 0.016
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0185 0.0315
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.0754 0.0753
Mycobacterium ulcerans carbonic anhydrase 0.0275 0.1073 0.7291
Giardia lamblia Sgs1 DNA helicase, putative 0.0038 0.0077 0.3196
Leishmania major carbonic anhydrase family protein, putative 0.0275 0.1073 0.6449
Entamoeba histolytica hypothetical protein 0.0039 0.0078 0.0714
Brugia malayi jmjC domain containing protein 0.012 0.042 0.1135
Schistosoma mansoni hypothetical protein 0.0126 0.0445 0.0761
Echinococcus granulosus lamin 0.0083 0.0266 0.0269
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0436 0.0745
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0004 0.0025
Echinococcus granulosus phd:f box containing protein 0.0031 0.0045 0.0044
Toxoplasma gondii exonuclease III APE 0.0077 0.0237 0.1607
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.0762 0.2062
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0068 0.0183
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0045 0.0118
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0058 0.0161 0.0274
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0216 0.0824 0.4948
Plasmodium falciparum carbonic anhydrase 0.0302 0.1186 1
Toxoplasma gondii phosphofructokinase PFKII 0.0058 0.0161 0.1086
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0027 0.0029 0.0192
Toxoplasma gondii melibiase subfamily protein 0.0124 0.0436 0.2955
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0026 0.0149
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0058 0.0161 0.1086
Plasmodium vivax vivapain-2 0.0033 0.0054 0.1085
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0078 0.0184
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0268
Loa Loa (eye worm) hypothetical protein 0.0053 0.0139 0.0374
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0054 0.036
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.0754 0.0764
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0054 0.0053
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0217 0.0828 0.5621
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0004 0.0016
Onchocerca volvulus 0.0033 0.0054 0.0125
Schistosoma mansoni lipoxygenase 0.0055 0.0147 0.0251
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0266 0.0719
Loa Loa (eye worm) hypothetical protein 0.0302 0.1186 0.321
Onchocerca volvulus 0.0431 0.173 0.4105
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0078 0.0131
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0041 0.0086 0.0086
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0054 0.036
Leishmania major hypothetical protein, conserved 0.0026 0.0026 0.0149
Schistosoma mansoni hypothetical protein 0.0064 0.0183 0.0313
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0089 0.0237
Entamoeba histolytica peptidase, C54 family 0.0023 0.0011 0.0094
Echinococcus multilocularis protein patched 0.0086 0.0278 0.0277
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0027 0.0029 0.0192
Echinococcus granulosus neutral amino acid transporter A 0.0251 0.097 0.0983
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0161 0.0382
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0161 0.0382
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0217 0.0828 0.5621
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0119 0.0416 0.2823
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0436 0.0745
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0078 0.0208
Echinococcus multilocularis lysine specific demethylase 5A 0.0115 0.04 0.0399
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0241 0.0929 0.6313
Loa Loa (eye worm) hypothetical protein 0.0072 0.0216 0.0583
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0024 0.0024
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0008 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0824 0.1955
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0442 0.2653
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0268
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0416 0.1664 0.4505
Brugia malayi Cathepsin L-like precursor 0.0033 0.0054 0.0143
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0007 0.0006
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0251 0.097 0.0969
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0004 0.0018
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.0161 0.0961
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0216 0.1464
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.0161 0.0961
Schistosoma mansoni DNA helicase recq5 0.0038 0.0077 0.0129
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0026 0.0479
Mycobacterium leprae Conserved hypothetical protein 0.0027 0.0029 0.0264
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0031 0.0045 0.0075
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0027 0.0029 0.0192
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.0228 0.0231
Brugia malayi Peptidase family C54 containing protein 0.0058 0.0161 0.0433
Echinococcus multilocularis chromobox protein 1 0.0068 0.0202 0.0201
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0007 0.0016
Onchocerca volvulus 0.1022 0.4212 1
Schistosoma mansoni hypothetical protein 0.0335 0.1325 0.2271
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0016
Loa Loa (eye worm) CUTiclin family member 0.0044 0.01 0.0268
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0078 0.0078
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0054 0.0422
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0032 0.0051 0.005
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.037 0.1472 0.1492
Echinococcus granulosus neuropeptide s receptor 0.0463 0.1864 0.1889
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.013 0.0464 0.0793
Schistosoma mansoni microtubule-associated protein tau 0.1407 0.5833 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0118
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0086 0.0279 0.259
Leishmania major cathepsin L-like protease 0.0125 0.0442 0.2653
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0416 0.1664 0.2851
Plasmodium falciparum thioredoxin reductase 0.0095 0.0315 0.2636
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0216 0.1464
Onchocerca volvulus 0.0044 0.01 0.0235
Brugia malayi chromobox protein homolog 3 0.0038 0.0076 0.0204
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0086 0.0279 0.1888
Loa Loa (eye worm) hypothetical protein 0.0082 0.0262 0.0708
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0442 0.2653
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0023 0.0011 0.0068
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0004 0.0007
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.0161 0.0961
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0073 0.0173
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0112 0.0112
Brugia malayi Bloom's syndrome protein homolog 0.0065 0.0187 0.0505
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0053 0.0311
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0051 0.0085
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0161 0.0382
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0044 0.01 0.2094
Mycobacterium ulcerans aldehyde dehydrogenase 0.037 0.1472 1
Echinococcus multilocularis nmda type glutamate receptor 0.0035 0.0063 0.0062
Echinococcus multilocularis 6 phosphofructokinase 0.0216 0.0824 0.0823
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0227
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0027 0.0029 0.0192
Brugia malayi Excitatory amino acid transporter 0.0251 0.097 0.2625
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0161 0.0382
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0278 0.0281
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0073 0.0671
Loa Loa (eye worm) hypothetical protein 0.0146 0.053 0.1434
Echinococcus multilocularis carbonic anhydrase II 0.0416 0.1664 0.1663
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0077 0.0237 0.2203
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0027 0.0029 0.0192
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0078 0.0077
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0054 0.0491
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0088 0.0207
Onchocerca volvulus 0.0044 0.01 0.0235
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0089 0.0208
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0097 0.0097
Brugia malayi jmjC domain containing protein 0.0031 0.0045 0.0118
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0078 0.0077
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0112 0.0111
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0053 0.031
Plasmodium falciparum thrombospondin-related anonymous protein 0.0044 0.01 0.0815
Trypanosoma cruzi cysteine peptidase, putative 0.0125 0.0442 0.2653
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0103 0.0277
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0016
Brugia malayi intermediate filament protein 0.0083 0.0266 0.0719
Onchocerca volvulus 0.0033 0.0054 0.0125
Echinococcus granulosus voltage dependent calcium channel subunit 0.1075 0.4438 0.4501
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0056 0.0148
Echinococcus multilocularis expressed protein 0.0033 0.0056 0.0055
Echinococcus multilocularis Peptidase C54 0.0058 0.0161 0.016
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.0315 0.0319
Brugia malayi Cathepsin L-like precursor 0.0022 0.0008 0.0019
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0068 0.0405
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0004 0.0009
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0027 0.0029 0.0192
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0007 0.001
Brugia malayi 6-phosphofructokinase 0.0216 0.0824 0.2229
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0185 0.0315
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0068 0.0458
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0054 0.2241
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0089 0.0237
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0004 0.0018
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0054 0.0054
Echinococcus multilocularis geminin 0.0335 0.1325 0.1324
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0077 0.0237 0.2439
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0054 0.0053
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0216 0.2008
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0053 0.014
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0004 0.0018
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0064 0.0183 0.0494
Leishmania major ATP-dependent phosphofructokinase 0.0216 0.0824 0.4948
Trichomonas vaginalis rotamase, putative 0.0033 0.0056 0.0133
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0112 0.019
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0278 0.075
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.037 0.1472 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0111 0.0383 0.0382
Schistosoma mansoni DNA helicase recq1 0.0038 0.0077 0.0129
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0054 0.009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0183 0.0185
Schistosoma mansoni hypothetical protein 0.0335 0.1325 0.2271
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0185 0.0315
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0044 0.01 0.0268
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0027 0.0029 0.0192
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0217 0.0828 0.7709
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0124 0.0436 0.0435
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0054 0.0425
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0078 0.0208
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0004 0.0016
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0027 0.0029 0.0192
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0078 0.0208
Echinococcus granulosus survival motor neuron protein 1 0.049 0.1977 0.2004
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0416 0.0988
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0161 0.1178
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0824 0.1955
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0078 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0054 0.0127
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0118
Brugia malayi Cathepsin L-like precursor 0.0022 0.0008 0.0019
Onchocerca volvulus 0.0083 0.0266 0.063
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.0824 0.7672
Entamoeba histolytica hypothetical protein 0.0039 0.0078 0.0714
Schistosoma mansoni thyroid hormone receptor 0.0167 0.0618 0.1058
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0004 0.0018
Loa Loa (eye worm) glutamate receptor 1 0.0074 0.0227 0.0614
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0089 0.0237
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0377
Plasmodium vivax thrombospondin-related anonymous protein 0.0044 0.01 0.2094
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0053 0.031
Mycobacterium tuberculosis Probable dehydrogenase 0.0217 0.0828 0.5621
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0185 0.0184
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0088 0.021
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0011 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0008 0.0019
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0054 0.0053
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0027 0.0029 0.0192
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0017 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0089 0.0237
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.0824 0.7672
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0054 0.0143
Brugia malayi Kringle domain containing protein 0.0024 0.0016 0.004
Brugia malayi Zona pellucida-like domain containing protein 0.0044 0.01 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0056 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0442 0.2653
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.0262 0.0623
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.0228 0.1367
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0004 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0054 0.0127
Schistosoma mansoni hypothetical protein 0.0044 0.01 0.017
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0004 0.0018
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0054 0.0318
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0112 0.0111
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0004 0.0018
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0268
Trichomonas vaginalis set domain proteins, putative 0.1022 0.4212 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0262 0.0448
Brugia malayi Cytochrome P450 family protein 0.0036 0.0068 0.0183
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0099 0.0592
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.0315 0.6773
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0268
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.0762 0.2062
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0045 0.0262
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0004 0.0016
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0017 0.0016
Brugia malayi Cache domain containing protein 0.0476 0.1918 0.5193
Schistosoma mansoni cell polarity protein 0.0024 0.0017 0.0028
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0073 0.0072
Entamoeba histolytica carbonic anhydrase, putative 0.0275 0.1073 1
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.0494 0.1336
Echinococcus granulosus glutamate receptor 2 0.0066 0.0194 0.0195
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0195
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0041 0.0086 0.0085
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0089 0.0089
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0054 0.0125
Mycobacterium ulcerans hypothetical protein 0.0072 0.0216 0.1464
Echinococcus multilocularis chromobox protein 1 0.0068 0.0202 0.0201
Brugia malayi nuclear hormone receptor 0.0041 0.0089 0.0237
Brugia malayi Cathepsin L-like precursor 0.0033 0.0054 0.0143
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0027
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0027 0.0029 0.0192
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0026 0.0186
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0038 0.0077 0.0077
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0068 0.0405
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0237
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0089 0.0237
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0078 0.0078
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0278 0.0277
Entamoeba histolytica elongation factor-2 kinase, putative 0.0044 0.01 0.0924
Toxoplasma gondii endonuclease IV APN 0.0086 0.0279 0.1888
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.002 0.0001 0.0003
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0027 0.0029 0.0192
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0089 0.015
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0202 0.048
Schistosoma mansoni lamin 0.0083 0.0266 0.0455
Treponema pallidum glutamate/aspartate transporter 0.0111 0.0383 0.0837
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.01 0.0268
Echinococcus granulosus expressed conserved protein 0.0189 0.0708 0.0718
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0266 0.0719
Schistosoma mansoni phosphatidylserine receptor 0.0031 0.0045 0.0075
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0202 0.0545
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0089 0.0208
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0436 0.1179
Loa Loa (eye worm) hypothetical protein 0.0138 0.0494 0.1336
Trichomonas vaginalis DNA helicase recq, putative 0.0065 0.0187 0.0445
Schistosoma mansoni intermediate filament proteins 0.0083 0.0266 0.0455
Loa Loa (eye worm) hypothetical protein 0.0039 0.0078 0.0208
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0058 0.0161 0.0274
Echinococcus granulosus bloom syndrome protein 0.0065 0.0187 0.0189
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0268
Brugia malayi laminin alpha chain 0.0024 0.0017 0.0044
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0004 0.0018
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0114 0.0396 0.2378
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0007 0.0006
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0054 0.0014
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0237
Leishmania major cathepsin L-like protease 0.0033 0.0054 0.0316
Treponema pallidum exodeoxyribonuclease (exoA) 0.0077 0.0237 0.0518
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0054 0.0127
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0054 0.0128
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0004 0.0018
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0054 0.0318
Echinococcus granulosus nmda type glutamate receptor 0.0035 0.0063 0.0062
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0007 0.001
Schistosoma mansoni jumonji/arid domain-containing protein 0.012 0.042 0.0719
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0161 0.1329
Loa Loa (eye worm) CXXC zinc finger family protein 0.0085 0.0274 0.0739
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0216 0.1464
Brugia malayi Phospholipase A2 family protein 0.0091 0.0298 0.0805
Loa Loa (eye worm) hypothetical protein 0.0302 0.1186 0.321
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0053 0.014
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0038 0.0077 0.0205
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0027 0.0029 0.0192
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0053 0.0123
Leishmania major cathepsin L-like protease 0.0125 0.0442 0.2653
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0251 0.097 0.0969
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0044 0.01 0.2094
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0251 0.097 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0019
Schistosoma mansoni carbonic anhydrase-related 0.0302 0.1186 0.2031
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.1864 0.1863
Echinococcus multilocularis Excitatory amino acid transporter 0.0251 0.097 0.0969
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0027 0.0029 0.0192
Loa Loa (eye worm) hypothetical protein 0.0039 0.0078 0.0208
Schistosoma mansoni autophagin-1 (C54 family) 0.0058 0.0161 0.0274
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0054 0.0125

Activities

Activity type Activity value Assay description Source Reference
-Log EC50 (binding) = 1 Direct activation of human Gamma-aminobutyric-acid A receptor alpha1-beta2-gamma2 ChEMBL. 12109905
-Log EC50 (functional) = 2.8 Loss of righting reflex (LORR) in tadpoles was determined for anesthetic activity ChEMBL. 12109905
-Log EC50 (binding) = 3 Potentiation of GABA responses at human Gamma-aminobutyric-acid A receptor alpha1-beta2-gamma2 ChEMBL. 12109905
Activity (ADMET) < 1 % Membrane retention in 70% silicon-30% IPM membrane ChEMBL. 16789751
Activity (ADMET) = 2.9 % Membrane retention in 100% silicon membrane ChEMBL. 16789751
Activity (ADMET) = 6.3 % Membrane retention in 100% IPM membrane ChEMBL. 16789751
Activity (functional) < 15 % Activity against caspase-mediated apoptosis in mouse L1210 cells at 0.1 mM ChEMBL. 16279782
Activity (functional) < 15 % Activity against caspase-mediated apoptosis in mouse L1210 cells at 0.1 mM ChEMBL. 16279782
Activity (ADMET) = 33.4 % Membrane permeability, CA(t)/CD(0) in 100% silicon membrane ChEMBL. 16789751
Activity (ADMET) = 45.4 % Membrane permeability, CA(t)/CD(0) in 100% IPM membrane ChEMBL. 16789751
Activity (ADMET) = 46.7 % Membrane permeability, CA(t)/CD(0) in 70% silicon-30% IPM membrane ChEMBL. 16789751
Activity (ADMET) = 1 pm/min/mg Specific activity of expressed human recombinant UGT1A6 ChEMBL. 10836148
Activity (ADMET) = 1.3 pm/min/mg Specific activity of expressed human recombinant UGT1A6 ChEMBL. 10836148
Binding energy (ADMET) = 2.7 kCal mol-1 Binding energy of the compound was determined by using the equation deltaG obsd = -RT ln KD ChEMBL. 6094812
clogP = 1.46 Calculated partition coefficient (clogP) ChEMBL. 11527738
clogP = 1.5 Calculated partition coefficient (clogP) ChEMBL. 12109905
EC50 (binding) = 1 Direct activation of human Gamma-aminobutyric-acid A receptor alpha1-beta2-gamma2 ChEMBL. 12109905
EC50 (binding) = 3 Potentiation of GABA responses at human Gamma-aminobutyric-acid A receptor alpha1-beta2-gamma2 ChEMBL. 12109905
HD50 (functional) = 70 mg kg-1 Hypnotic activity was measured as dose which causes loss of righting reflex for a minimum period of 30s in 50% of mice ChEMBL. 7452689
HD50 (functional) = 70 mg kg-1 Hypnotic activity was measured as dose which causes loss of righting reflex for a minimum period of 30s in 50% of mice ChEMBL. 7452689
I50 (functional) = 0.0015 M Inhibitory activity of the compound on germination of B. subtilis PCI219 spores was determined. ChEMBL. 6802973
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (functional) = 16045 nM Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay ChEMBL. 17944451
IC50 (functional) = 16045 nM Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay ChEMBL. 17944451
IC50 (functional) = 16535 nM Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay ChEMBL. 17944451
IC50 (functional) = 16535 nM Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay ChEMBL. 17944451
IC50 (functional) > 100 uM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 after 48 hrs by lactate dehydrogenase assay ChEMBL. 22196513
Inhibition (binding) Competitive inhibition of human erythrocytes CA1 using 4-nitrophenylacetate as substrate by Lineweaver-Burk plot analysis ChEMBL. 26073005
Kcat (binding) = 12.7 /s Substrate activity at mushroom tyrosinase assessed as Kcat for monophenolase activity in presence H2O2 by spectrophotometry based Michaelis-Menten plot analysis ChEMBL. 27480027
Kcat/Km (binding) = 18.1 /mM/s Substrate activity at mushroom tyrosinase assessed as Kcat/Km ratio for monophenolase activity in presence H2O2 by spectrophotometry based Michaelis-Menten plot analysis ChEMBL. 27480027
Kd (binding) = 90.9 uM Dissociation constant against T4 lysozyme mutant L99A/M102Q ChEMBL. 15916423
Kd (binding) = 90.9 uM Dissociation constant against T4 lysozyme mutant L99A/M102Q ChEMBL. 15916423
Ki (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
Ki (binding) = 2.7 uM Inhibition of human CA3 by stopped-flow CO2 hydration assay ChEMBL. 20185318
Ki (binding) = 2.7 uM Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration method ChEMBL. 20590092
Ki (binding) = 2.7 uM Inhibition of human carbonic anhydrase 3 after 15 mins by stopped flow CO2 hydration method ChEMBL. 20674354
Ki (binding) = 2.7 uM Inhibition of human carbonic anhydrase 3 preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 23010455
Ki (binding) = 5.5 uM Inhibition of human CA2 by stopped-flow CO2 hydration assay ChEMBL. 20185318
Ki (binding) = 5.5 uM Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration method ChEMBL. 20590092
Ki (binding) = 5.5 uM Inhibition of human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration method ChEMBL. 20674354
Ki (binding) = 5.5 uM Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 21282059
Ki (binding) = 5.5 uM Inhibition of human recombinant alpha-carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay ChEMBL. 21332115
Ki (binding) = 5.5 uM Inhibition of human CA2 by stopped-flow assay ChEMBL. 23265898
Ki (binding) = 5.5 uM Inhibition of human carbonic anhydrase 2 by stopped flow assay ChEMBL. 23265903
Ki (binding) = 5.5 uM Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 23010455
Ki (binding) = 5.5 uM Inhibition of human recombinant carbonic anhydrase 2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay ChEMBL. 24189056
Ki (binding) = 5.5 uM Inhibition of human erythrocytes CA2 using 4-nitrophenylacetate as substrate by esterase assay ChEMBL. 26073005
Ki (binding) = 5.5 uM Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay ChEMBL. 26520662
Ki (binding) = 8.8 uM Inhibition of human CA9 by stopped-flow CO2 hydration assay ChEMBL. 20185318
Ki (binding) = 8.8 uM Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration method ChEMBL. 20590092
Ki (binding) = 8.8 uM Inhibition of human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration method ChEMBL. 20674354
Ki (binding) = 8.8 uM Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 21282059
Ki (binding) = 8.8 uM Inhibition of human CA9 by stopped-flow assay ChEMBL. 23265898
Ki (binding) = 8.8 uM Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 23010455
Ki (binding) = 8.8 uM Inhibition of human recombinant carbonic anhydrase 9-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay ChEMBL. 24189056
Ki (binding) = 8.8 uM Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay ChEMBL. 26520662
Ki (binding) = 9.2 uM Inhibition of human CA12 by stopped-flow CO2 hydration assay ChEMBL. 20185318
Ki (binding) = 9.2 uM Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration method ChEMBL. 20590092
Ki (binding) = 9.2 uM Inhibition of human carbonic anhydrase 12 after 15 mins by stopped flow CO2 hydration method ChEMBL. 20674354
Ki (binding) = 9.2 uM Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 21282059
Ki (binding) = 9.2 uM Inhibition of human CA12 by stopped-flow assay ChEMBL. 23265898
Ki (binding) = 9.2 uM Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 23010455
Ki (binding) = 9.2 uM Inhibition of human recombinant carbonic anhydrase 12-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay ChEMBL. 24189056
Ki (binding) = 9.5 uM Inhibition of human CA4 by stopped-flow CO2 hydration assay ChEMBL. 20185318
Ki (binding) = 9.5 uM Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration method ChEMBL. 20590092
Ki (binding) = 9.5 uM Inhibition of human carbonic anhydrase 4 after 15 mins by stopped flow CO2 hydration method ChEMBL. 20674354
Ki (binding) = 9.5 uM Inhibition of human carbonic anhydrase 4 preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 23010455
Ki (binding) = 10.1 uM Inhibition of human recombinant alpha-carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay ChEMBL. 21332115
Ki (binding) = 10.2 uM Inhibition of human CA1 by stopped-flow CO2 hydration assay ChEMBL. 20185318
Ki (binding) = 10.2 uM Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration method ChEMBL. 20590092
Ki (binding) = 10.2 uM Inhibition of human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration method ChEMBL. 20674354
Ki (binding) = 10.2 uM Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 21282059
Ki (binding) = 10.2 uM Inhibition of human CA1 by stopped-flow assay ChEMBL. 23265898
Ki (binding) = 10.2 uM Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 23010455
Ki (binding) = 10.2 uM Inhibition of human recombinant carbonic anhydrase 1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay ChEMBL. 24189056
Ki (binding) = 10.2 uM Inhibition of human erythrocytes CA1 using 4-nitrophenylacetate as substrate by esterase assay ChEMBL. 26073005
Ki (binding) = 10.2 uM Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay ChEMBL. 26520662
Ki (binding) = 10.5 uM Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay ChEMBL. 18501600
Ki (binding) = 10.5 uM Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay ChEMBL. 18501600
Ki (binding) = 10.5 uM Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration method ChEMBL. 20590092
Ki (binding) = 10.5 uM Inhibition of mouse carbonic anhydrase 15 after 15 mins by stopped flow CO2 hydration method ChEMBL. 20674354
Ki (binding) = 11.5 uM Inhibition of human CA14 by stopped-flow CO2 hydration assay ChEMBL. 20185318
Ki (binding) = 11.5 uM Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration method ChEMBL. 20590092
Ki (binding) = 11.5 uM Inhibition of human carbonic anhydrase 14 after 15 mins by stopped flow CO2 hydration method ChEMBL. 20674354
Ki (binding) = 11.5 uM Inhibition of human carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 23010455
Ki (binding) = 13.7 uM Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay ChEMBL. 21669522
Ki (binding) = 17.3 uM Inhibition of Candida albicans recombinant Nce103 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay ChEMBL. 21332115
Ki (binding) = 25.9 uM Inhibition of Cryptococcus neoformans recombinant Can2 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay ChEMBL. 21332115
Ki (binding) = 64 uM Inhibition of Mycobacterium tuberculosis recombinant Rv1284 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay ChEMBL. 21332115
Ki (binding) = 79 uM Inhibition of Mycobacterium tuberculosis recombinant Rv3273 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay ChEMBL. 21332115
Ki (binding) = 208 uM Inhibition of human CA6 by stopped-flow CO2 hydration assay ChEMBL. 20185318
Ki (binding) = 208 uM Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration method ChEMBL. 20590092
Ki (binding) = 208 uM Inhibition of human carbonic anhydrase 6 after 15 mins by stopped flow CO2 hydration method ChEMBL. 20674354
Ki (binding) = 208 uM Inhibition of human carbonic anhydrase 6 preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 23010455
Ki (binding) = 218 uM Inhibition of human CA5A by stopped-flow CO2 hydration assay ChEMBL. 20185318
Ki (binding) = 218 uM Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration method ChEMBL. 20590092
Ki (binding) = 218 uM Inhibition of human carbonic anhydrase 5a after 15 mins by stopped flow CO2 hydration method ChEMBL. 20674354
Ki (binding) = 218 uM Inhibition of human carbonic anhydrase 5A preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 23010455
Ki (binding) > 500 uM Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration method ChEMBL. 20590092
Ki (binding) > 500 uM Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration method ChEMBL. 20590092
Ki (binding) > 500 uM Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration method ChEMBL. 20590092
Ki (binding) = 543 uM Inhibition of human CA5B by stopped-flow CO2 hydration assay ChEMBL. 20185318
Ki (binding) = 543 uM Inhibition of human carbonic anhydrase 5b after 15 mins by stopped flow CO2 hydration method ChEMBL. 20674354
Ki (binding) = 543 uM Inhibition of human carbonic anhydrase 5B preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 23010455
Ki (binding) = 697 uM Inhibition of mouse CA13 by stopped-flow CO2 hydration assay ChEMBL. 20185318
Ki (binding) = 697 uM Inhibition of human carbonic anhydrase 13 after 15 mins by stopped flow CO2 hydration method ChEMBL. 20674354
Ki (binding) = 697 uM Inhibition of human carbonic anhydrase 13 preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 23010455
Ki (binding) = 710 uM Inhibition of human CA7 by stopped-flow CO2 hydration assay ChEMBL. 20185318
Ki (binding) = 710 uM Inhibition of human carbonic anhydrase 7 after 15 mins by stopped flow CO2 hydration method ChEMBL. 20674354
Ki (binding) = 710 uM Inhibition of human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assay ChEMBL. 23010455
Kii (binding) = 112 mM Intecept inhibition constant of the compound was determined against Alpha-Fucosidase; Noncompetitive inhibition ChEMBL. No reference
Kii (binding) = 112 mM Intecept inhibition constant of the compound was determined against Alpha-Fucosidase; Noncompetitive inhibition ChEMBL. No reference
Kis (binding) = 0.18 mM Slope inhibition constant of the compound was determined against Alpha-Fucosidase; Uncompetitive inhibition ChEMBL. No reference
Kis (binding) = 0.18 mM Slope inhibition constant of the compound was determined against Alpha-Fucosidase; Uncompetitive inhibition ChEMBL. No reference
Km (binding) = 0.019 mM Apparent Michaelis constant (Km) against Arylsulfotransferase (AST IV) ChEMBL. 12459019
Km (binding) = 0.019 mM Apparent Michaelis constant (Km) against Arylsulfotransferase (AST IV) ChEMBL. 12459019
Km (binding) = 700 uM Substrate activity at mushroom tyrosinase assessed as Km for monophenolase activity in presence H2O2 by spectrophotometry based Michaelis-Menten plot analysis ChEMBL. 27480027
LD50 (ADMET) = 100 mg kg-1 Acute toxicity measured as median lethal dose in mice ChEMBL. 7452689
LD50 (ADMET) = 100 mg kg-1 Acute toxicity measured as median lethal dose in mice ChEMBL. 7452689
LD50 (ADMET) = 270 mg kg-1 Toxicity in mouse ChEMBL. 25849312
LD50 (ADMET) = 270 mg kg-1 Toxicity in mouse ChEMBL. 24015326
Log 1/C (binding) = 3.32 Binding constant against bovine serum albumin ChEMBL. 3172126
Log 1/C (binding) = 3.32 Binding constant against bovine serum albumin ChEMBL. 3172126
Log 1/I50 (functional) = 2.82 Inhibition of B. subtilis PCI219 spore germination, expressed as log 1/I50 ChEMBL. 6802973
Log EC50 (ADMET) = 2.704 Toxicity determined using Microtox Test ChEMBL. 2033592
Log k' w (ADMET) = 1.251 Capacity ratio (log k'w) ChEMBL. 3172126
Log K-1 (ADMET) = -2.5 compound was evaluated for reverse occurs for the rate constant(log K-1) at pH 7.4 ChEMBL. 9526560
Log K1 (ADMET) = -0.68 compound was evaluated for rate constant of transfer (log K1) at pH 7.4 ChEMBL. 9526560
log Kp (ADMET) = -5.64 Permeability across human Skin ChEMBL. 17300161
log Kp (ADMET) = -5.54 cm/s Permeability in human skin ChEMBL. 16789751
log Kp (ADMET) = -5.54 cm/s Permeability in human skin ChEMBL. 16789751
log Kp (ADMET) = -4.45 cm/s Permeability coefficient in silicon membrane using diffusion cells ChEMBL. 16789751
Log LC50 (ADMET) = -0.256 Toxicity determined using Golden Orfe Fish Test ChEMBL. 2033592
Log MBC (functional) = 1 Inhibition of Rana pipiens muscle activity. ChEMBL. 2033592
log Pe (ADMET) = -4.14 Permeability across PAMPA membrane after 7 hrs ChEMBL. 17300161
log Pe (ADMET) = -4.53 cm/s Effective permeability coefficient in 100% silicon membrane ChEMBL. 16789751
log Pe (ADMET) = -4.14 cm/s Effective permeability coefficient in 70% silicon-30% IPM membrane ChEMBL. 16789751
log Pe (ADMET) = -4 cm/s Effective permeability coefficient in 100% IPM membrane ChEMBL. 16789751
Log Phep (ADMET) = -0.82 Partition coefficient of compound was measured in haptane/water system ChEMBL. 8254605
Log PNalk = -0.82 Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system ChEMBL. 15857133
Log S = 0 Aqueous solubility ChEMBL. 10866370
log(1/ID50) (functional) = -0.2 Activity against caspase-mediated apoptosis in mouse L1210 cells ChEMBL. 16279782
log(1/ID50) (ADMET) = 2.56 Cytotoxicity against human MCF7 cells ChEMBL. 16279782
log(1/ID50) (ADMET) = 2.65 Cytotoxicity against human CEM/VLB cells ChEMBL. 16279782
log(1/ID50) (ADMET) = 3.05 Cytotoxicity against human HL60 cells ChEMBL. 16279782
log(1/ID50) (ADMET) = 3.27 Cytotoxicity against mouse L1210 cells ChEMBL. 16279782
log(1/ID50) (ADMET) = 3.27 Cytotoxicity against human CCRF-CEM cells ChEMBL. 16279782
logD (ADMET) = 1.48 Partition coefficient (logD7.2) ChEMBL. 6802973
logD (ADMET) = 1.54 Partition coefficient (logD3.0) ChEMBL. 9526560
logP (ADMET) = -1.04 Partition coefficient (logP) (dodecane) ChEMBL. 11754587
logP (ADMET) = -0.7 Partition coefficient (logP) (hexane) ChEMBL. 3599019
logP (ADMET) = -0.36 Partition coefficient (logP) (carbon tetrachloride) ChEMBL. 3599019
logP (ADMET) = 0.36 Partition coefficient (logP) (benzene) ChEMBL. 3599019
logP (ADMET) = 0.37 Partition coefficient (logP) (chloroform) ChEMBL. 3599019
logP (ADMET) = 1.46 Partition coefficient (logP) ChEMBL. 3172126
logP (ADMET) = 1.46 Partition coefficient (logP) ChEMBL. 2993621
logP (ADMET) = 1.46 Partition coefficient (logP) ChEMBL. 8254605
logP (ADMET) = 1.46 Partition coefficient (logP) ChEMBL. 3599019
LogP = 1.46 Partition coefficient, log P of the compound ChEMBL. 17300161
LogP = 1.47 Partition coefficient, log P of the compound ChEMBL. 17418579
logP (ADMET) = 1.48 Partition coefficient (logP) ChEMBL. 8254605
logP (ADMET) = 1.48 Partition coefficient (logP) ChEMBL. 6802973
logP (ADMET) = 1.49 Partition coefficient (logP) ChEMBL. 7310804
logP (ADMET) = 1.5 Partition coefficient (logP) ChEMBL. 11754587
logP (ADMET) = 1.64 Partition coefficient (logP) (ether) ChEMBL. 3599019
LogP app (ADMET) = -4.33 Permeability coefficient through artificial membrane in presence of unstirred water layer by PAMPA ChEMBL. 17418579
LogP app (ADMET) = -3.83 Permeability coefficient through artificial membrane in presence of stirred water layer ChEMBL. 17418579
Papp (ADMET) = 47.05 10^-6 cm/s Permeability coefficient through artificial membrane in presence of unstirred water layer by PAMPA ChEMBL. 17418579
Papp (ADMET) = 147.1 10^-6 cm/s Permeability coefficient through artificial membrane in presence of stirred water layer ChEMBL. 17418579
pka (ADMET) = 9.97 Acidity of compound was determined ChEMBL. 7310804
pKa = 9.99 Dissociation constant, pKa of the compound ChEMBL. 16789751
pKa = 10 Dissociation constant (pKa) ChEMBL. 6802973
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.6011 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of androgen receptor signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 76.9588 uM PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 223.8721 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of androgen receptor signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1000 uM PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1122.0185 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of retinoid X receptor alpha signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1122.0185 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of peroxisome proliferator-activated receptor gamma signaling. (Class of assay: confirmatory) ChEMBL. No reference
R% (ADMET) = 8 % Membrane retention of the compound in permeability experiment with artificial membrane ChEMBL. 17418579
Ratio (binding) = 625 Ratio of kcat/Km determined for catalytic efficiency of the compound in sulfonation against AST IV ChEMBL. 12459019
Vmax (binding) = 350 nM min-1 Maximal velocity of the compound (Vmax) against Arylsulfotransferase (AST IV) ChEMBL. 12459019
Vmax (binding) = 350 nM min-1 Maximal velocity of the compound (Vmax) against Arylsulfotransferase (AST IV) ChEMBL. 12459019

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17944451

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

62 literature references were collected for this gene.

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