Detailed information for compound 1358859

Basic information

Technical information
  • TDR Targets ID: 1358859
  • Name: 1-[(5-chloro-1,3-dimethylpyrazol-4-yl)methyl] -N-[4-(1,3-thiazol-4-yl)phenyl]piperidine-3-c arboxamide
  • MW: 429.966 | Formula: C21H24ClN5OS
  • H donors: 1 H acceptors: 3 LogP: 3.45 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCN(C1)Cc1c(C)nn(c1Cl)C)Nc1ccc(cc1)c1cscn1
  • InChi: 1S/C21H24ClN5OS/c1-14-18(20(22)26(2)25-14)11-27-9-3-4-16(10-27)21(28)24-17-7-5-15(6-8-17)19-12-29-13-23-19/h5-8,12-13,16H,3-4,9-11H2,1-2H3,(H,24,28)
  • InChiKey: WNDWGJZPJBORCN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(5-chloro-1,3-dimethyl-pyrazol-4-yl)methyl]-N-(4-thiazol-4-ylphenyl)piperidine-3-carboxamide
  • 1-[(5-chloro-1,3-dimethyl-4-pyrazolyl)methyl]-N-[4-(4-thiazolyl)phenyl]-3-piperidinecarboxamide
  • 1-[(5-chloro-1,3-dimethyl-pyrazol-4-yl)methyl]-N-(4-thiazol-4-ylphenyl)nipecotamide
  • 1-[(5-chloro-1,3-dimethyl-pyrazol-4-yl)methyl]-N-[4-(1,3-thiazol-4-yl)phenyl]piperidine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei heat shock protein 90, putative 0.0109 0.0289 0.0951
Echinococcus granulosus jumonji domain containing 1A 0.0043 0.0084 0.0125
Schistosoma mansoni endoplasmin 0.0109 0.0289 0.0444
Entamoeba histolytica cysteine proteinase 2 0.0021 0.0015 0.0048
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0064 0.1121
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0129 0.0195
Loa Loa (eye worm) hypothetical protein 0.0143 0.0394 0.1007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0206
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0043 0.0083 0.0127
Entamoeba histolytica hypothetical protein 0.0072 0.0173 0.0574
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0013
Brugia malayi Cytochrome P450 family protein 0.0018 0.0005 0.0006
Mycobacterium tuberculosis Conserved protein 0.0038 0.0067 0.0623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0076 0.0277
Onchocerca volvulus Peroxidase homolog 0.0026 0.0032 0.0145
Brugia malayi Cathepsin L-like precursor 0.0041 0.0076 0.0189
Brugia malayi hypothetical protein 0.0066 0.0155 0.0392
Brugia malayi hypothetical protein 0.0072 0.0173 0.0439
Loa Loa (eye worm) hypothetical protein 0.0058 0.013 0.0328
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0038 0.0067 0.0099
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0083 0.0206
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0298 0.5303
Echinococcus granulosus Regulator of differentiation 1 0.0024 0.0026 0.0036
Brugia malayi nuclear receptor RXR 0.0038 0.0069 0.017
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0013 0.0026
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0005 0.0005
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0093 0.024 1
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.0029
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0198 0.0195
Schistosoma mansoni peroxidasin 0.0027 0.0033 0.0051
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0089 0.0227 0.0846
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0363 0.0559
Loa Loa (eye worm) hypothetical protein 0.0121 0.0326 0.0829
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.001 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0021
Entamoeba histolytica cysteine protease, putative 0.0021 0.0015 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0024
Trypanosoma brucei isocitrate dehydrogenase, putative 0.008 0.0198 0.065
Onchocerca volvulus 0.0026 0.0032 0.0145
Schistosoma mansoni rab6-interacting 0.0039 0.0072 0.011
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.001 0.0028
Onchocerca volvulus 0.0041 0.0077 0.0379
Leishmania major cathepsin L-like protease 0.0089 0.0225 0.409
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0033 0.0053 0.0175
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Echinococcus granulosus geminin 0.086 0.2618 0.4028
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.001 0.0011
Echinococcus granulosus cathepsin l1 0.0041 0.0076 0.0113
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0044 0.0041
Loa Loa (eye worm) hypothetical protein 0.0081 0.0202 0.0511
Brugia malayi hypothetical protein 0.0017 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0015 0.0046
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0072 0.1272
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0069 0.0335
Trypanosoma brucei unspecified product 0.0019 0.001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0081 0.0202 0.0511
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0082 0.0122
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0081 0.0202 0.0306
Brugia malayi Doublecortin family protein 0.0039 0.0072 0.0177
Brugia malayi jmjC domain containing protein 0.0043 0.0084 0.0208
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0093 0.024 0.2511
Schistosoma mansoni lipoxygenase 0.0173 0.0487 0.0748
Onchocerca volvulus Peroxidase homolog 0.0026 0.0032 0.0145
Brugia malayi MH2 domain containing protein 0.0024 0.0025 0.0058
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.006 0.0148
Schistosoma mansoni smad1 5 8 and 0.0024 0.0025 0.0038
Trypanosoma brucei SIR2-like protein 4, putative 0.0033 0.0053 0.0168
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.017
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0112 0.0298 0.5303
Brugia malayi Cathepsin L-like precursor 0.0027 0.0035 0.0082
Schistosoma mansoni dishevelled 0.0017 0.0004 0.0006
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.008 0.0198 0.0301
Loa Loa (eye worm) hypothetical protein 0.0036 0.0063 0.0156
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0013 0.0026
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.0064 0.0203
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0053 0.019
Brugia malayi jmjC domain containing protein 0.0043 0.0084 0.0208
Echinococcus multilocularis Zinc finger, PHD finger 0.0017 0.0003 0.00000096064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0024
Schistosoma mansoni dynamin 0.0046 0.0091 0.014
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.0069 0.017
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.002 0.0011 0.0021
Echinococcus granulosus smad 0.0024 0.0025 0.0035
Brugia malayi MH1 domain containing protein 0.0024 0.0025 0.0058
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0072 0.0069
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0033 0.0053 0.005
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0268 0.4776
Entamoeba histolytica heat shock protein 90, putative 0.0109 0.0289 0.0958
Mycobacterium ulcerans Sir2-like regulatory protein 0.0033 0.0053 0.0181
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.0223 0.2331
Plasmodium falciparum endoplasmin, putative 0.0072 0.0174 0.3091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0225 0.0739
Leishmania major DNA polymerase kappa, putative 0.0019 0.001 0.0135
Loa Loa (eye worm) glutaminase 2 0.0872 0.2657 0.682
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0009 0.0017
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.013 0.0354 0.0541
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0081 0.0202 0.0199
Trypanosoma brucei polo-like protein kinase 0.0192 0.0546 0.1806
Trypanosoma cruzi cysteine peptidase, putative 0.0041 0.0076 0.0244
Onchocerca volvulus 0.0041 0.0076 0.0374
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0079
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0129 0.0421
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0069 0.017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0067 0.0165
Brugia malayi kinase, mitochondrial precursor 0.002 0.0011 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0076 0.0277
Echinococcus multilocularis dna polymerase kappa 0.0019 0.001 0.0007
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0009 0.0017
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0037 0.0064 0.0586
Trichomonas vaginalis heat shock protein, putative 0.0072 0.0174 0.0644
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0446 0.0444
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.001 0.0015
Trypanosoma cruzi cruzipain precursor, putative 0.0089 0.0225 0.0739
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0081 0.0202 0.0511
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.001 0.0135
Echinococcus granulosus dnaJ subfamily B 0.1324 0.4058 0.6245
Schistosoma mansoni peroxidasin 0.0026 0.0032 0.0049
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0069 0.0066
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0129 0.0421
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.0198 0.0658
Mycobacterium tuberculosis Conserved protein 0.002 0.0011 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0363 0.0559
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0061 0.009
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0156 0.0236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0225 0.0739
Trichomonas vaginalis dynamin, putative 0.0042 0.0081 0.0296
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0129 0.043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.013 0.0354 0.0902
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0156 0.0153
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.002 0.0011 0.0008
Trypanosoma cruzi Double RNA binding domain protein 3 0.0018 0.0007 0.0014
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0009 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0202 0.0199
Loa Loa (eye worm) hypothetical protein 0.0047 0.0097 0.0243
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0053 0.0081
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0033 0.0053 0.0078
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0033 0.0053 0.0175
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0032 0.0145
Echinococcus multilocularis peregrin 0.0033 0.0052 0.0049
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0041 0.0076 0.0073
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0024
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0125 0.0337 0.0858
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0225 0.0739
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0546 0.2047
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0064 0.0157
Echinococcus multilocularis heat shock protein 0.0109 0.0289 0.0286
Echinococcus multilocularis dynamin 1 protein 0.0042 0.0081 0.0079
Loa Loa (eye worm) hypothetical protein 0.0081 0.0202 0.0511
Brugia malayi Papain family cysteine protease containing protein 0.0021 0.0015 0.0032
Trypanosoma cruzi heat shock protein 85, putative 0.0109 0.0289 0.0951
Loa Loa (eye worm) hypothetical protein 0.0093 0.0239 0.0607
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0017 0.0003 0.0009
Trypanosoma cruzi heat shock protein 90, putative 0.009 0.0228 0.0749
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0314 0.0925 1
Echinococcus granulosus RUN 0.0039 0.0072 0.0106
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0067 0.0064
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0338 0.1 0.2562
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0021 0.0015 0.0022
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0069 0.0102
Schistosoma mansoni glutaminase 0.0872 0.2657 0.409
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0129 0.0477
Brugia malayi Cathepsin L-like precursor 0.0041 0.0076 0.0189
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.006 0.0217
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0268 0.0881
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0084 0.0208
Schistosoma mansoni regulator of G protein signaling 0.0036 0.0063 0.0097
Onchocerca volvulus Serine\/threonine kinase homolog 0.0192 0.0546 0.2817
Schistosoma mansoni cpg binding protein 0.013 0.0355 0.0545
Mycobacterium ulcerans two component sensor kinase MprB 0.002 0.0011 0.0021
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0253 0.0734 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0033 0.0053 0.0175
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0076 0.0277
Echinococcus granulosus JmjC domain containing protein 4 0.0043 0.0084 0.0125
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Echinococcus multilocularis GPCR, family 2 0.0207 0.0594 0.0591
Echinococcus granulosus chromatin regulatory protein sir2 0.0033 0.0053 0.0078
Loa Loa (eye worm) fibroinase 0.0041 0.0076 0.0189
Leishmania major 4-coumarate:coa ligase-like protein 0.0125 0.0337 0.6148
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.006 0.0217
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.006 0.0217
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.0015 0.0048
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0298 0.5303
Leishmania major silent information regulator 2, putative 0.0033 0.0053 0.0928
Trichomonas vaginalis DNA topoisomerase II, putative 0.002 0.0011 0.0031
Brugia malayi beta-lactamase 0.0038 0.0067 0.0165
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0076
Plasmodium vivax unspecified product 0.0021 0.0015 0.0259
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0036 0.0063 0.0156
Brugia malayi Cathepsin L-like precursor 0.0041 0.0076 0.0189
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.001 0.0019
Schistosoma mansoni alpha-glucosidase 0.0138 0.0377 0.058
Loa Loa (eye worm) phosphatidylinositol 3 0.0104 0.0271 0.069
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0198 0.3596
Echinococcus multilocularis tar DNA binding protein 0.0133 0.0363 0.0361
Brugia malayi Probable DNA topoisomerase II 0.002 0.0011 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0024
Entamoeba histolytica cysteine protease, putative 0.0021 0.0015 0.0048
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0032 0.0076
Trypanosoma cruzi cysteine proteinase, putative 0.0021 0.0015 0.0041
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.013 0.0354 0.0351
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0129 0.0421
Echinococcus granulosus heat shock protein 90 0.0109 0.0289 0.0441
Mycobacterium ulcerans oxidoreductase 0.0112 0.0298 0.1102
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0067 0.0623
Plasmodium falciparum phd finger protein, putative 0.0031 0.0045 0.0791
Trypanosoma brucei heat shock protein, putative 0.0109 0.0289 0.0951
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0546 0.2047
Leishmania major cathepsin L-like protease 0.0041 0.0076 0.1351
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0097 0.0145
Echinococcus granulosus segment polarity protein dishevelled 0.0017 0.0004 0.0002
Onchocerca volvulus 0.0637 0.1928 1
Plasmodium falciparum heat shock protein 90, putative 0.0197 0.0561 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0215 0.0546
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0219 0.0631 0.1614
Loa Loa (eye worm) hypothetical protein 0.0253 0.0734 0.1879
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0036 0.0124
Echinococcus granulosus tumor protein p63 0.1061 0.3243 0.499
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0053 0.019
Echinococcus multilocularis FTZ F1 alpha 0.0081 0.0202 0.0199
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0045 0.0149
Schistosoma mansoni hypothetical protein 0.0046 0.0092 0.0141
Loa Loa (eye worm) hypothetical protein 0.0038 0.0067 0.0165
Trichomonas vaginalis glutaminase, putative 0.0872 0.2657 1
Entamoeba histolytica cysteine protease, putative 0.0021 0.0015 0.0048
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Plasmodium vivax heat shock protein 86, putative 0.0109 0.0289 0.5148
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0037 0.0064 0.0061
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0032 0.0076
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0067 0.0623
Brugia malayi Bromodomain containing protein 0.0038 0.0068 0.0168
Leishmania major hypothetical protein, conserved 0.0038 0.0067 0.1184
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0155 0.0432 0.1103
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.006 0.0217
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.0223 0.2331
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0041 0.0076 0.0189
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.002 0.0011 0.0031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.0223 0.2331
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.0029
Loa Loa (eye worm) hypothetical protein 0.0267 0.0777 0.199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0015 0.0046
Leishmania major 4-coumarate:coa ligase-like protein 0.0125 0.0337 0.6148
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.006 0.02
Loa Loa (eye worm) hypothetical protein 0.0049 0.0103 0.0258
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0056 0.0124 0.0625
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.002 0.0011 0.0008
Leishmania major acetyl-CoA synthetase, putative 0.0037 0.0064 0.1121
Echinococcus granulosus lysine specific histone demethylase 1A 0.0458 0.137 0.2106
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0076 0.0277
Loa Loa (eye worm) hypothetical protein 0.1271 0.3894 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0112 0.0298 0.098
Brugia malayi conserved hypotetical protein 0.0038 0.0069 0.017
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0033 0.0053 0.0941
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.002 0.0011 0.0027
Echinococcus multilocularis phd:f box containing protein 0.0043 0.0084 0.0081
Toxoplasma gondii LsmAD domain-containing protein 0.0102 0.0268 0.089
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0112 0.0298 0.5303
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.002 0.0011 0.0008
Schistosoma mansoni nuclear receptor 0.0038 0.0069 0.0105
Loa Loa (eye worm) DR-78 0.0038 0.0069 0.017
Toxoplasma gondii SWIRM domain-containing protein 0.0037 0.0064 0.0213
Echinococcus granulosus peregrin 0.0033 0.0052 0.0076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0076 0.0277
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0024
Entamoeba histolytica cysteine protease, putative 0.0021 0.0015 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0064 0.0231
Onchocerca volvulus 0.0038 0.0069 0.0335
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.002 0.0011 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.0223 0.2331
Onchocerca volvulus 0.0038 0.0067 0.0327
Schistosoma mansoni hypothetical protein 0.0046 0.0092 0.0141
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0005 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0067 0.1188
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0045 0.0108
Trichomonas vaginalis heat shock protein, putative 0.009 0.0228 0.0849
Loa Loa (eye worm) hypothetical protein 0.0093 0.0239 0.0607
Schistosoma mansoni heat shock protein 0.0109 0.0289 0.0444
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0076 0.0277
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0146 0.0367
Trichomonas vaginalis dynamin, putative 0.0042 0.0081 0.0296
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0038 0.0067 0.0064
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0056 0.0124 0.0122
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.0064 0.023
Loa Loa (eye worm) hypothetical protein 0.0046 0.0091 0.0228
Mycobacterium ulcerans hypothetical protein 0.0125 0.0337 0.125
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0112 0.0298 0.8794
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0067 0.1725
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0084 0.0212 0.0209
Mycobacterium ulcerans acetyl-CoA synthetase 0.0037 0.0064 0.022
Trypanosoma cruzi cysteine peptidase, putative 0.0089 0.0225 0.0739
Schistosoma mansoni smad1 5 8 and 0.0024 0.0025 0.0038
Toxoplasma gondii cathepsin CPL 0.0041 0.0076 0.0253
Schistosoma mansoni hypothetical protein 0.0021 0.0014 0.002
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0069 0.017
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0017 0.0004 0.0064
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0069 0.017
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0129 0.2331
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0064 0.0203
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.007 0.0067
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0192 0.0546 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0017 0.0003 0.0007
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0053 0.0175
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0546 0.2047
Echinococcus multilocularis lamin 0.008 0.0199 0.0196
Mycobacterium tuberculosis Possible oxidoreductase 0.0112 0.0298 0.3143
Echinococcus multilocularis lamin dm0 0.008 0.0199 0.0196
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0823 0.2503 0.3851
Loa Loa (eye worm) hypothetical protein 0.0467 0.1399 0.3588
Plasmodium falciparum acyl-CoA synthetase 0.0093 0.0239 0.426
Brugia malayi beta-lactamase family protein 0.0038 0.0067 0.0165
Leishmania major RNA-binding protein, putative 0.0018 0.0007 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0024
Entamoeba histolytica dynamin-1-like protein, putative 0.0042 0.0081 0.0268
Echinococcus granulosus dynamin 0.0042 0.0081 0.0121
Echinococcus granulosus Pleckstrin G protein interacting region 0.0017 0.0004 0.0002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0081 0.0202 0.031
Leishmania major hypothetical protein, conserved 0.0018 0.0007 0.0076
Echinococcus multilocularis dynamin 0.0042 0.0081 0.0079
Entamoeba histolytica heat shock protein 90, putative 0.0109 0.0289 0.0958
Giardia lamblia Heat shock protein HSP 90-alpha 0.009 0.0228 0.3012
Brugia malayi hypothetical protein 0.0112 0.0298 0.0757
Echinococcus multilocularis cpg binding protein 0.013 0.0355 0.0352
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0024
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.001 0.0007
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0021 0.0015 0.0041
Plasmodium vivax vivapain-1 0.0021 0.0015 0.0259
Toxoplasma gondii heat shock protein HSP90 0.0109 0.0289 0.0959
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0354 0.105 0.5435
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.002 0.0011 0.0008
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0081 0.0202 0.0306
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0458 0.137 0.1368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0225 0.0739
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0036 0.0124
Plasmodium falciparum heat shock protein 90, putative 0.0052 0.0113 0.2006
Loa Loa (eye worm) hypothetical protein 0.0207 0.0594 0.1519
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0013 0.0019
Trypanosoma brucei heat shock protein, putative 0.0109 0.0289 0.0951
Trichomonas vaginalis helicase, putative 0.0028 0.0036 0.0124
Loa Loa (eye worm) hypothetical protein 0.0093 0.0239 0.0607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0225 0.0739
Schistosoma mansoni zinc finger protein 0.0026 0.0032 0.0048
Entamoeba histolytica poly(ADP-ribose) glycohydrolase, putative 0.0986 0.3011 1
Plasmodium vivax heat shock protein, putative 0.0197 0.0561 1
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Toxoplasma gondii poly(ADP-ribose) glycohydrolase 0.0986 0.3011 1
Brugia malayi hypothetical protein 0.0017 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0076 0.0277
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0458 0.137 0.2108
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0064 0.022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.004 0.0075 0.0114
Trypanosoma cruzi heat shock protein 85, putative 0.0109 0.0289 0.0951
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0013
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0005 0.0006
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0033 0.0053 0.0168
Onchocerca volvulus 0.0027 0.0035 0.0157
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.017
Schistosoma mansoni chromatin regulatory protein sir2 0.0253 0.0734 0.1129
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.002 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0067 0.0165
Echinococcus multilocularis JmjC domain containing protein 4 0.0043 0.0084 0.0081
Toxoplasma gondii histone deacetylase SIR2-like 0.0033 0.0053 0.0177
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0032 0.0076
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0064 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0076 0.0277
Toxoplasma gondii dynamin-related protein DRPA 0.0042 0.0081 0.027
Plasmodium falciparum protoporphyrinogen oxidase 0.0112 0.0298 0.5303
Trypanosoma cruzi heat shock protein 90, putative 0.0109 0.0289 0.0951
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0044 0.0085 0.0311
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0067 0.0165
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.0064 0.0157
Schistosoma mansoni alpha-glucosidase 0.0138 0.0377 0.058
Echinococcus multilocularis dna polymerase eta 0.0019 0.001 0.0007
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0037 0.0064 0.022
Mycobacterium tuberculosis Probable sensor protein KdpD 0.002 0.0011 0.0008
Echinococcus multilocularis survival motor neuron protein 1 0.0467 0.1399 0.1397
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0081 0.0202 0.0199
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.002 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.017
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.002 0.0011 0.0027
Onchocerca volvulus 0.0018 0.0007 0.0013
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.0011 0.0021
Schistosoma mansoni polypyrimidine tract binding protein 0.0024 0.0026 0.0039
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0037 0.0064 0.0212
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0067 0.0214
Plasmodium vivax endoplasmin, putative 0.0109 0.0289 0.5148
Loa Loa (eye worm) RecQ helicase 0.0024 0.0025 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0076 0.0277
Echinococcus multilocularis thyroid hormone receptor alpha 0.0081 0.0202 0.0199
Mycobacterium ulcerans beta-lactamase 0.0038 0.0067 0.0233
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0081 0.0202 0.0511
Schistosoma mansoni jumonji/arid domain-containing protein 0.017 0.0478 0.0735
Trichomonas vaginalis heat shock protein, putative 0.0093 0.024 0.0893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0076 0.0277
Brugia malayi transcriptional regulator, Sir2 family protein 0.0033 0.0053 0.013
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0081 0.0202 0.0511
Schistosoma mansoni smad1 5 8 and 0.0024 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.007 0.0168 0.0425
Loa Loa (eye worm) hypothetical protein 0.0081 0.0202 0.0511
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0017 0.0003 0.0003
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0013
Loa Loa (eye worm) transcriptional regulator 0.0033 0.0053 0.013
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0067 0.0623
Loa Loa (eye worm) endoplasmin 0.0109 0.0289 0.0735
Schistosoma mansoni cathepsin F (C01 family) 0.0041 0.0076 0.0116
Mycobacterium ulcerans NAD-dependent deacetylase 0.0033 0.0053 0.0181
Leishmania major hypothetical protein, conserved 0.0102 0.0268 0.488
Loa Loa (eye worm) hypothetical protein 0.0093 0.0239 0.0607
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Echinococcus multilocularis expressed conserved protein 0.0104 0.0272 0.0269
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0056 0.0124 0.0187
Entamoeba histolytica cysteine protease, putative 0.0041 0.0076 0.0251
Brugia malayi hypothetical protein 0.0043 0.0083 0.0206
Brugia malayi SWIRM domain containing protein 0.0494 0.1484 0.3806
Brugia malayi nuclear receptor NHR-67 0.0038 0.0069 0.017
Brugia malayi nuclear receptor NHR-88 0.0038 0.0069 0.017
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.006 0.0217
Entamoeba histolytica hypothetical protein 0.0986 0.3011 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0037 0.0064 0.0061
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0044 0.0085 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0035 0.012
Trypanosoma brucei heat shock protein 90, putative 0.0109 0.0289 0.0951
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0064 0.0586
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0033 0.0053 0.0168
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0082
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0123 0.0333 0.0512
Mycobacterium tuberculosis Two component sensor kinase MprB 0.002 0.0011 0.0008
Brugia malayi jmjC domain containing protein 0.0043 0.0084 0.0208
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.017
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0032 0.0145
Brugia malayi hypothetical protein 0.0019 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.017
Onchocerca volvulus 0.0125 0.0337 0.1729
Brugia malayi jmjC domain containing protein 0.0043 0.0084 0.0208
Echinococcus multilocularis segment polarity protein dishevelled 0.0017 0.0004 0.0002
Toxoplasma gondii Hsp90 domain-containing protein 0.0197 0.0561 0.1861
Loa Loa (eye worm) hypothetical protein 0.0037 0.0066 0.0161
Echinococcus multilocularis protoporphyrinogen oxidase 0.0112 0.0298 0.0295
Entamoeba histolytica SWIRM domain protein 0.0037 0.0064 0.0211
Brugia malayi PXA domain containing protein 0.0019 0.0009 0.0017
Entamoeba histolytica hypothetical protein 0.0037 0.0064 0.0211
Brugia malayi CXXC zinc finger family protein 0.0121 0.0327 0.0833
Giardia lamblia hypothetical protein 0.0037 0.0064 0.0745
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0003 0.0003
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0045 0.0042
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0009 0.0007
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.008 0.0198 0.3529
Trypanosoma brucei DNA topoisomerase ii 0.002 0.0011 0.0027
Loa Loa (eye worm) TAR-binding protein 0.0133 0.0363 0.0927
Onchocerca volvulus 0.0041 0.0076 0.0374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0076 0.0277
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.0363 0.0927
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0037 0.0064 0.0586
Echinococcus multilocularis geminin 0.086 0.2618 0.2616
Schistosoma mansoni hypothetical protein 0.0046 0.0092 0.0141
Giardia lamblia Grp94/Hsp90 0.0093 0.024 0.3172
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0093 0.0139
Giardia lamblia Kinase, PLK 0.0192 0.0546 0.7406
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0081 0.0202 0.0511
Entamoeba histolytica acyl-CoA synthetase, putative 0.0125 0.0337 0.1117
Brugia malayi PHD-finger family protein 0.0031 0.0045 0.0108
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0032 0.0145
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0192 0.0546 0.1396
Treponema pallidum heat shock protein 90 0.0093 0.024 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0041 0.0076 0.0073
Onchocerca volvulus 0.0038 0.0069 0.0335
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0069 0.017
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0033 0.0053 0.005
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0069 0.017
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0076 0.0189
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0037 0.0064 0.162
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0083 0.0127
Brugia malayi MH2 domain containing protein 0.0024 0.0025 0.0058
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.0363 0.0927
Loa Loa (eye worm) hypothetical protein 0.0081 0.0202 0.0511
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.0202 0.0511
Brugia malayi photoreceptor-specific nuclear receptor 0.0081 0.0202 0.0511
Toxoplasma gondii RNA recognition motif-containing protein 0.0024 0.0026 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0225 0.0739
Brugia malayi Bromodomain containing protein 0.0081 0.0203 0.0514
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0206
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0011
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0041 0.0038
Schistosoma mansoni hypothetical protein 0.0207 0.0594 0.0914
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0076 0.0277
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0037 0.0064 0.0586
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0004 0.0006
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.002 0.0011 0.0027
Echinococcus granulosus lamin dm0 0.008 0.0199 0.0302
Echinococcus multilocularis heat shock protein 90 0.0109 0.0289 0.0286
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0067 0.0099
Trypanosoma brucei heat shock protein, putative 0.0109 0.0289 0.0951
Loa Loa (eye worm) hypothetical protein 0.0112 0.0298 0.0757
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0076 0.0277
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0024
Brugia malayi steroid hormone receptor 0.0081 0.0202 0.0511
Schistosoma mansoni hypothetical protein 0.0031 0.0045 0.0068
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0045 0.079
Brugia malayi Smad1 0.0024 0.0025 0.0058
Schistosoma mansoni hypothetical protein 0.0448 0.1341 0.2064
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.002 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.017
Entamoeba histolytica cysteine protease, putative 0.0021 0.0015 0.0048
Brugia malayi CHE-14 protein 0.0047 0.0097 0.0243
Giardia lamblia Sirtuin type 2 0.0033 0.0053 0.0595
Trypanosoma cruzi heat shock protein 85, putative 0.0109 0.0289 0.0951
Echinococcus multilocularis lysine specific demethylase 6a 0.0043 0.0084 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.0202 0.0511
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0448 0.1341 0.3439
Trichomonas vaginalis dynamin, putative 0.0042 0.0081 0.0296
Toxoplasma gondii hypothetical protein 0.0017 0.0004 0.0014
Brugia malayi hypothetical protein 0.0026 0.0032 0.0076
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0009 0.001
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.015
Brugia malayi Cathepsin L-like precursor 0.0041 0.0076 0.0189
Loa Loa (eye worm) hypothetical protein 0.0637 0.1928 0.4946
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0192 0.0546 0.0544
Brugia malayi DIX domain containing protein 0.0017 0.0004 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0081 0.0202 0.031
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0064 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0081 0.0202 0.0511
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.0293 0.029
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0093 0.0239 0.0882
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0081 0.0202 0.0511
Echinococcus granulosus tar DNA binding protein 0.0133 0.0363 0.0555
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.008 0.0198 0.353
Plasmodium vivax DNA gyrase subunit B, putative 0.002 0.0011 0.0184
Brugia malayi AMP-binding enzyme family protein 0.0125 0.0337 0.0858
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0037 0.0064 0.162
Mycobacterium ulcerans two component regulator - sensor kinase 0.002 0.0011 0.0021
Entamoeba histolytica hypothetical protein 0.0072 0.0173 0.0574
Onchocerca volvulus Cathepsin F homolog 0.0041 0.0076 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0036 0.0124
Giardia lamblia Heat shock protein HSP 90-alpha 0.0109 0.0289 0.3851
Mycobacterium ulcerans putative regultory protein 0.002 0.0011 0.0021
Echinococcus multilocularis chromatin regulatory protein sir2 0.0033 0.0053 0.005
Schistosoma mansoni hypothetical protein 0.0046 0.0093 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0036 0.0124
Brugia malayi Niemann-Pick C1 protein precursor 0.011 0.0293 0.0745
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0024
Echinococcus multilocularis poly(ADP ribose) glycohydrolase 0.0986 0.3011 0.3009
Brugia malayi AMP-binding enzyme family protein 0.0125 0.0337 0.0858
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0081 0.0202 0.0511
Plasmodium falciparum cysteine proteinase falcipain 3 0.0041 0.0076 0.1351
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0083 0.0207
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0036 0.0124
Brugia malayi tailless protein 0.0038 0.0069 0.017
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0017 0.0004 0.0006
Leishmania major heat shock protein, putative 0.0056 0.0124 0.224
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.002 0.0011 0.0008
Schistosoma mansoni steroid hormone receptor ad4bp 0.0081 0.0202 0.031
Brugia malayi hypothetical protein 0.0039 0.0072 0.0177
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0037 0.0064 0.0203
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0067 0.0233
Echinococcus granulosus lamin 0.008 0.0199 0.0302
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0198 0.0195
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0053 0.019
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0009 0.0007
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0037 0.0064 0.0094
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0004 0.0063
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0053 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0076 0.0277
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0044 0.0085 0.013
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0037 0.0064 0.0586
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.017
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0125 0.0337 0.3573
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0017 0.0003 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0011 0.0016
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.0015 0.0048
Onchocerca volvulus DNA topoisomerase 2 homolog 0.002 0.0011 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0125 0.0337 0.0858
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0081 0.0202 0.031
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.001 0.0019
Loa Loa (eye worm) Poly(ADP-ribose) glycohydrolase 0.0986 0.3011 0.7731
Trypanosoma cruzi cysteine peptidase, putative 0.0089 0.0225 0.0739
Loa Loa (eye worm) hypothetical protein 0.0039 0.007 0.0173
Plasmodium vivax dynamin-like protein, putative 0.0042 0.0081 0.1441
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0053 0.019
Brugia malayi PHD-finger family protein 0.0032 0.0048 0.0117
Brugia malayi Dynamin central region family protein 0.0042 0.0081 0.0202
Brugia malayi Cathepsin L-like precursor 0.0041 0.0076 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.0202 0.0511
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0207 0.0594 0.0591
Loa Loa (eye worm) hypothetical protein 0.0071 0.0172 0.0435
Plasmodium vivax NAD-dependent deacetylase, putative 0.0033 0.0053 0.094
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0043 0.0084 0.0269
Mycobacterium ulcerans acyl-CoA synthetase 0.0125 0.0337 0.125
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0041 0.0076 0.0277
Trypanosoma cruzi dynamin-1-like protein 0.0042 0.0081 0.0261
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0037 0.0064 0.0212
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0173 0.0487 0.0484
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0129 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.0202 0.0511
Entamoeba histolytica acyl-CoA synthetase, putative 0.0125 0.0337 0.1117
Brugia malayi Cathepsin L-like cysteine proteinase 0.0027 0.0035 0.0082
Brugia malayi SWIRM domain containing protein 0.0037 0.0064 0.0157
Entamoeba histolytica cysteine protease, putative 0.0021 0.0015 0.0048
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0112 0.0298 0.5303
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0044 0.0085 0.0311
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0052 0.0111 0.0167
Echinococcus granulosus lysine specific demethylase 6a 0.0043 0.0084 0.0125
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0009 0.001
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0069 0.0066
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0067 0.0102
Trypanosoma cruzi heat shock protein 90, putative 0.0057 0.0126 0.041
Leishmania major GTP-binding protein, putative 0.0042 0.0081 0.1445
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0157
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0033 0.0053 0.0168
Trichomonas vaginalis heat shock protein, putative 0.0109 0.0289 0.1078
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0041 0.0063
Echinococcus multilocularis endoplasmin 0.0093 0.024 0.0237
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0053 0.0081
Plasmodium falciparum polypyrimidine tract-binding protein, putative 0.0024 0.0026 0.0453
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0043 0.0084 0.0269
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0076
Schistosoma mansoni bromodomain containing protein 0.007 0.0167 0.0256
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0067 0.0242
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0067 0.0623
Loa Loa (eye worm) transcriptional regulator 0.0033 0.0053 0.013
Trypanosoma brucei heat shock protein, putative 0.0109 0.0289 0.0951
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0069 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0069 0.0066
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0206
Loa Loa (eye worm) hypothetical protein 0.0125 0.0337 0.0858
Trypanosoma cruzi Heat shock protein 83, putative 0.0109 0.0289 0.0951
Brugia malayi hypothetical protein 0.0637 0.1928 0.4946
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0037 0.0064 0.022
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.0015 0.0048
Giardia lamblia PHD finger protein 15 0.0031 0.0045 0.048
Schistosoma mansoni phd/f-box containing protein 0.0043 0.0084 0.0128
Toxoplasma gondii heat shock protein 90, putative 0.0109 0.0289 0.0959
Onchocerca volvulus 0.0041 0.0076 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0024
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0017 0.0003 0.000001479
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0207 0.0594 0.1519
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.008 0.0198 0.0304
Entamoeba histolytica hypothetical protein 0.0072 0.0173 0.0574
Loa Loa (eye worm) heat shock protein 75 0.0056 0.0124 0.0313
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0113 0.0415
Schistosoma mansoni alpha glucosidase 0.0035 0.006 0.0092
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.001 0.0028
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0009 0.0013
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0067 0.0165
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0017 0.0003 0.0007
Brugia malayi jmjC domain containing protein 0.0224 0.0646 0.1654
Mycobacterium tuberculosis Conserved protein 0.0038 0.0067 0.0623
Schistosoma mansoni hypothetical protein 0.0207 0.0594 0.0914
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0032 0.0076
Mycobacterium ulcerans acyl-CoA synthetase 0.0125 0.0337 0.125
Schistosoma mansoni cathepsin F (C01 family) 0.0041 0.0076 0.0116
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0009 0.0013
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.002 0.0011 0.0185
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0076
Onchocerca volvulus Bile acid receptor homolog 0.0081 0.0202 0.1026
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0025 0.0023
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0093 0.024 0.7021
Loa Loa (eye worm) hypothetical protein 0.0149 0.0411 0.105
Onchocerca volvulus 0.008 0.0199 0.101
Trichomonas vaginalis endoplasmin, putative 0.0072 0.0174 0.0644
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.002 0.0011 0.0008
Onchocerca volvulus 0.0041 0.0076 0.0374
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0031 0.0048 0.0413
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0032 0.0076
Brugia malayi ecdysone receptor 0.0038 0.0069 0.017
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0093 0.024 0.4361
Loa Loa (eye worm) DRP-1 protein 0.0042 0.0081 0.0202
Onchocerca volvulus 0.0092 0.0237 0.121
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0009 0.0025
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.001 0.0018
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0037 0.0064 0.022
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0224 0.0646 0.0644
Schistosoma mansoni thyroid hormone receptor 0.0081 0.0202 0.031
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0129 0.0477
Trypanosoma brucei heat shock protein, putative 0.0109 0.0289 0.0951
Echinococcus granulosus cpg binding protein 0.013 0.0355 0.0542
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0043 0.0084 0.0278
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0033 0.0053 0.0078
Loa Loa (eye worm) transcription factor SMAD2 0.0356 0.1055 0.2703
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0125 0.0337 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0125 0.0337 0.125
Trypanosoma cruzi cysteine protease, putative 0.0021 0.0015 0.0041
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0025 0.0023
Schistosoma mansoni phosphatidylserine receptor 0.0043 0.0084 0.0128
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0041 0.0076 0.1351
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0033 0.0053 0.0168
Loa Loa (eye worm) hypothetical protein 0.0038 0.0068 0.0169
Leishmania major cathepsin L-like protease 0.0041 0.0076 0.1351
Schistosoma mansoni jumonji/arid domain-containing protein 0.017 0.0478 0.0735
Echinococcus multilocularis regulator of G protein signaling 7 0.0036 0.0063 0.0061
Plasmodium vivax vivapain-2 0.0041 0.0076 0.135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0081 0.0202 0.0511
Entamoeba histolytica cysteine protease, putative 0.0021 0.0015 0.0048
Brugia malayi MAP kinase sur-1 0.0058 0.0129 0.0325
Leishmania major cathepsin L-like protease 0.0041 0.0076 0.1351
Leishmania major cathepsin L-like protease 0.0041 0.0076 0.1351
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.0546 0.084
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0045 0.0068
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0426 0.1272 0.4777
Leishmania major cysteine peptidase A (CPA) 0.0041 0.0076 0.1351
Trypanosoma cruzi cysteine peptidase, putative 0.0021 0.0015 0.0041
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0067 0.0233
Plasmodium vivax JmjC domain containing protein 0.0043 0.0084 0.1484
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.0446 0.114
Leishmania major developmentally regulated phosphoprotein-like protein 0.002 0.0011 0.015
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0033 0.0053 0.0928
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0076 0.0277
Plasmodium falciparum DNA gyrase subunit B 0.002 0.0011 0.0185
Brugia malayi Peroxidasin 0.0027 0.0033 0.0079
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.002 0.0011 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0076 0.0277
Brugia malayi cathepsin L-like precursor 0.0027 0.0035 0.0082
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0069 0.0102
Brugia malayi N-terminal motif family protein 0.0354 0.105 0.269
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0014 0.0028
Mycobacterium ulcerans glutaminase 0.0872 0.2657 1
Brugia malayi Nuclear hormone receptor-like 1 0.0081 0.0202 0.0511
Loa Loa (eye worm) beta-lactamase 0.0038 0.0067 0.0165
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0069 0.017
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.0015 0.0048
Plasmodium vivax dynamin protein, putative 0.0042 0.0081 0.1441
Brugia malayi PHD-finger family protein 0.0019 0.0009 0.0015
Schistosoma mansoni poly(ADP-ribose) glycohydrolase 0.0986 0.3011 0.4635
Schistosoma mansoni cpg binding protein 0.0121 0.0327 0.0503
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0013
Schistosoma mansoni polycystin 1-related 0.0039 0.0072 0.011
Brugia malayi PXA domain containing protein 0.0019 0.0009 0.0017
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0064 0.0586
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0016 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0076 0.0277
Schistosoma mansoni cellular tumor antigen P53 0.0155 0.0432 0.0664
Trypanosoma cruzi DNA topoisomerase II, putative 0.002 0.0011 0.0027
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0125 0.0337 0.125
Echinococcus multilocularis peroxidasin 0.0027 0.0033 0.0031
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0033 0.0053 0.0168
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0037 0.0064 0.022
Echinococcus granulosus dna polymerase eta 0.0019 0.001 0.0011
Schistosoma mansoni retinoic acid receptor RXR 0.0081 0.0202 0.031
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.0697 0.7514
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0036 0.0124
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.002 0.0011 0.0036
Trichomonas vaginalis receptor histidine kinase, putative 0.002 0.0011 0.0031
Brugia malayi latrophilin 2 splice variant baaae 0.0448 0.1341 0.3439
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.002 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0011
Schistosoma mansoni hypothetical protein 0.0039 0.0072 0.011
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0009 0.001
Brugia malayi Dynamin 0.0046 0.0091 0.0228
Entamoeba histolytica SWIRM domain protein 0.0037 0.0064 0.0211
Echinococcus multilocularis zinc finger protein 0.0026 0.0032 0.0029
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.0198 0.0658
Entamoeba histolytica cysteine protease, putative 0.0021 0.0015 0.0048
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0097 0.0243
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0043 0.0083 0.0206
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.002 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0038 0.0067 0.0165
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0081 0.0202 0.031
Trichomonas vaginalis mgm1, putative 0.0042 0.0081 0.0296
Brugia malayi Calcitonin receptor-like protein seb-1 0.0656 0.1985 0.5093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0194 0.0491
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0041 0.0076 0.0277
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0076
Echinococcus granulosus phd:f box containing protein 0.0043 0.0084 0.0125
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.001 0.0018
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0426 0.1272 0.4777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0225 0.0739
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0192 0.0546 0.0837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0076 0.0277
Echinococcus multilocularis ecdysone induced protein 78C 0.0081 0.0202 0.0199
Schistosoma mansoni hypothetical protein 0.1324 0.4058 0.6246
Giardia lamblia Transcriptional regulator, Sir2 family 0.0033 0.0053 0.0595
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0017
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.0069 0.0105
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0082
Echinococcus multilocularis dnaJ subfamily B 0.1324 0.4058 0.4056
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0011
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0097 0.0094
Toxoplasma gondii DNA topoisomerase 2, putative 0.002 0.0011 0.0036
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.002 0.0011 0.0008
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0009 0.0007
Schistosoma mansoni DNA topoisomerase II 0.002 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0093 0.0239 0.0607
Echinococcus multilocularis heat shock protein 90 0.009 0.0228 0.0225
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0011 0.0008
Schistosoma mansoni SWI/SNF complex-related 0.0037 0.0064 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0081 0.0202 0.0511
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0129 0.0421
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.002 0.0011 0.0021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0207 0.0594 0.0911
Schistosoma mansoni hypothetical protein 0.0384 0.1142 0.1758
Echinococcus granulosus dynamin 1 0.0046 0.0091 0.0137
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.002 0.0011 0.0027
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0082 0.0079
Onchocerca volvulus Huntingtin homolog 0.0364 0.1079 0.5586
Schistosoma mansoni endoplasmin 0.0109 0.0289 0.0444
Loa Loa (eye worm) hypothetical protein 0.0037 0.0066 0.0161
Brugia malayi glutaminase DH11.1 0.0872 0.2657 0.682
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.006 0.0198
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0009 0.0017
Echinococcus granulosus cysteine protease 0.0021 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0076
Schistosoma mansoni dep domain containing protein 0.0017 0.0004 0.0006
Brugia malayi Hsp90 protein 0.0056 0.0124 0.0313
Brugia malayi DNA topoisomerase II, alpha isozyme 0.002 0.0011 0.0021
Trypanosoma brucei developmentally regulated phosphoprotein 0.002 0.0011 0.0027
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.006 0.0058
Brugia malayi beta-lactamase family protein 0.0038 0.0067 0.0165
Trypanosoma brucei dynamin-1-like protein 0.0042 0.0081 0.0261
Onchocerca volvulus 0.0038 0.0067 0.0327
Toxoplasma gondii dynamin gtpase 0.0028 0.0037 0.0121
Trypanosoma cruzi poly(ADP-ribose) glycohydrolase, putative 0.0986 0.3011 1
Plasmodium vivax DNA topoisomerase II, putative 0.002 0.0011 0.0184
Echinococcus granulosus lysine specific histone demethylase 1A 0.0112 0.0298 0.0454
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.0202 0.0511
Echinococcus multilocularis cysteine protease 0.0041 0.0076 0.0073
Toxoplasma gondii dynamin-related protein DRPB 0.0042 0.0081 0.027
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0067 0.0242
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0044 0.0085 0.0274
Onchocerca volvulus 0.0026 0.0032 0.0145
Loa Loa (eye worm) steroid hormone receptor 0.0081 0.0202 0.0511
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0253 0.0734 0.1126
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0017 0.0003 0.004
Plasmodium vivax vivapain-2 0.0041 0.0076 0.135
Onchocerca volvulus 0.0037 0.0064 0.0309
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0069 0.0102
Plasmodium vivax ataxin-2 like protein, putative 0.0102 0.0268 0.4775
Echinococcus granulosus dna polymerase kappa 0.0019 0.001 0.0011
Trichomonas vaginalis receptor histidine kinase, putative 0.002 0.0011 0.0031
Schistosoma mansoni nuclear receptor 0.0038 0.0069 0.0105
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0081 0.0202 0.031
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0064 0.0157
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0084 0.0212 0.0322
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0033 0.0053 0.0175
Onchocerca volvulus 0.0038 0.0067 0.0327
Plasmodium vivax vivapain-3 0.0021 0.0015 0.0259
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0129 0.1648
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.013 0.0354 0.1167
Echinococcus multilocularis expressed protein 0.0371 0.1101 0.1099
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.017
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0044 0.0063
Echinococcus multilocularis Niemann Pick C1 protein 0.0158 0.044 0.0437
Entamoeba histolytica poly(ADP-ribose) glycohydrolase, putative 0.0439 0.1314 0.4362
Echinococcus granulosus survival motor neuron protein 1 0.0467 0.1399 0.2151
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0253 0.0734 0.2755
Echinococcus multilocularis cysteine protease 0.0041 0.0076 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0036 0.0124
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.001 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0546 0.2047
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0246 0.0624
Loa Loa (eye worm) hypothetical protein 0.0039 0.0072 0.0177
Trypanosoma brucei Double RNA-binding domain containing protein 4 0.0024 0.0026 0.0077
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0253 0.0734 0.2755
Brugia malayi amine oxidase, flavin-containing family protein 0.0149 0.0411 0.105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0015 0.0041
Plasmodium vivax polypyrimidine tract binding protein, putative 0.0024 0.0026 0.0452
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.013 0.0354 0.1174
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0017
Trypanosoma cruzi poly(ADP-ribose) glycohydrolase, putative 0.0986 0.3011 1
Trichomonas vaginalis esterase, putative 0.0038 0.0067 0.0242
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0017 0.0004 0.0004
Echinococcus granulosus expressed conserved protein 0.0104 0.0272 0.0415
Schistosoma mansoni smad 0.0024 0.0025 0.0038
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0253 0.0734 0.2755
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0076
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.002 0.0011 0.0036
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.002 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0013 0.0019
Schistosoma mansoni kinase 0.0098 0.0254 0.039
Brugia malayi serine/threonine-protein kinase plk-2 0.0192 0.0546 0.1396
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.004 0.0073 0.0234
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0076 0.0251
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0067 0.0214
Onchocerca volvulus 0.0041 0.0076 0.0374
Echinococcus multilocularis dynamin 1 0.0046 0.0091 0.0089
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0363 0.0559
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0122 0.0397
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0013 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0125 0.0337 0.3573
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0053 0.0081
Loa Loa (eye worm) heat shock protein 90 0.0109 0.0289 0.0735
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.002 0.0011 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0064 0.0157
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.006 0.0089
Echinococcus multilocularis jumonji domain containing 1A 0.0043 0.0084 0.0081
Chlamydia trachomatis protoporphyrinogen oxidase 0.0112 0.0298 1
Loa Loa (eye worm) transcriptional regulator 0.0033 0.0053 0.013
Echinococcus multilocularis smad 0.0024 0.0025 0.0023
Toxoplasma gondii propionate-CoA ligase 0.0037 0.0064 0.0212
Loa Loa (eye worm) hypothetical protein 0.0354 0.105 0.269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0035 0.012
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0009 0.0013
Onchocerca volvulus 0.0494 0.1484 0.7692
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0017 0.0003 0.0039
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.007 0.0104
Brugia malayi hypothetical protein 0.0364 0.1079 0.2765
Loa Loa (eye worm) CXXC zinc finger family protein 0.0121 0.0327 0.0833
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0072 0.0069
Plasmodium falciparum heat shock protein 90 0.0109 0.0289 0.5149
Echinococcus multilocularis segment polarity protein dishevelled 0.0017 0.0004 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0225 0.0739
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0037 0.0064 0.0586
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.017
Echinococcus multilocularis 0.0112 0.0298 0.0295
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0013 0.0019
Trypanosoma cruzi polo-like protein kinase, putative 0.0192 0.0546 0.1806
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0064 0.0157
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0009 0.0007
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0119 0.032 0.1064
Loa Loa (eye worm) hypothetical protein 0.0494 0.1484 0.3806
Onchocerca volvulus 0.008 0.0199 0.101
Leishmania major 4-coumarate:coa ligase-like protein 0.0125 0.0337 0.6148
Entamoeba histolytica cysteine protease, putative 0.0021 0.0015 0.0048
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.006 0.0217
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0017
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.006 0.0217
Plasmodium vivax acyl-CoA synthetase, putative 0.0093 0.0239 0.4259
Echinococcus granulosus lysine specific demethylase 5A 0.017 0.0478 0.0732
Trypanosoma brucei dynamin-1-like protein 0.0042 0.0081 0.0261
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0064 0.022
Echinococcus granulosus polyADP ribose glycohydrolase 0.0986 0.3011 0.4633
Mycobacterium ulcerans lipase LipD 0.0038 0.0067 0.0233
Schistosoma mansoni cpg binding protein 0.013 0.0355 0.0545
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0013 0.0015
Brugia malayi NAD-dependent deacetylase SIRT1 0.0253 0.0734 0.1879
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0093 0.009
Loa Loa (eye worm) hypothetical protein 0.008 0.0199 0.0503
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0053 0.0081
Trypanosoma cruzi polo-like protein kinase, putative 0.0192 0.0546 0.1806
Schistosoma mansoni acetyl-CoA synthetase 0.0037 0.0064 0.0097
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0268 0.0881
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0025
Schistosoma mansoni amine oxidase 0.0112 0.0298 0.0457
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.006 0.0191
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0033 0.0053 0.0078
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0076
Trypanosoma brucei Double RNA binding domain protein 3 0.0018 0.0007 0.0014
Echinococcus granulosus intermediate filament protein 0.008 0.0199 0.0302
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0076
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0072 0.0069
Entamoeba histolytica dynamin-like protein 0.0042 0.0081 0.0268
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0081 0.0202 0.031
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0081 0.0202 0.0511
Onchocerca volvulus Cathepsin L homolog 0.0041 0.0076 0.0374
Entamoeba histolytica cysteine protease, putative 0.0021 0.0015 0.0048
Schistosoma mansoni microtubule-associated protein tau 0.211 0.6496 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0013 0.0026
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0053 0.094
Schistosoma mansoni protein phosphatase 2C 0.0043 0.0084 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0225 0.0739
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Trypanosoma cruzi heat shock protein, putative 0.0056 0.0124 0.0405
Schistosoma mansoni dishevelled 0.0017 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.006
Echinococcus granulosus regulator of G protein signaling 7 0.0036 0.0063 0.0093
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0072 0.0106
Brugia malayi Blistered cuticle protein 3 0.0026 0.0032 0.0076
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0033 0.0053 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0173 0.0171
Schistosoma mansoni polypyrimidine tract binding protein 0.0018 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0206
Schistosoma mansoni hypothetical protein 0.086 0.2618 0.403
Trypanosoma cruzi cysteine proteinase, putative 0.0021 0.0015 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0067 0.0214
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0097 0.0145
Echinococcus granulosus peroxidasin 0.0027 0.0033 0.0047
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.006 0.0148
Onchocerca volvulus 0.0081 0.0202 0.1026
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0173 0.0487 0.0745
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0041 0.0076 0.1351
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.008 0.0198 0.0195
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0032 0.0076
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0082
Entamoeba histolytica acyl-coA synthetase, putative 0.0125 0.0337 0.1117
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0025
Brugia malayi Endoplasmin precursor 0.0109 0.0289 0.0735
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0112 0.0298 0.1102
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0081 0.0202 0.0511
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0005 0.0008
Giardia lamblia Dynamin 0.0042 0.0081 0.0983
Brugia malayi hypothetical protein 0.0039 0.0072 0.0177
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0045 0.0065
Brugia malayi heat shock protein 90 0.0109 0.0289 0.0735
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0084 0.0212 0.0537
Loa Loa (eye worm) cysteine protease 0.0041 0.0076 0.0189
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.0076 0.0189
Brugia malayi Bromodomain containing protein 0.0033 0.0052 0.0127
Echinococcus multilocularis protein dispatched 1 0.0054 0.0118 0.0115
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0037 0.0064 0.0157
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.002 0.0011 0.0021
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0129 0.0195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0015 0.0041
Plasmodium vivax heat shock protein 90, putative 0.0056 0.0124 0.2212
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0025
Brugia malayi Cytochrome P450 family protein 0.0018 0.0005 0.0006
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.017
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0058 0.0129 0.0427
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0129 0.0421
Plasmodium falciparum DNA topoisomerase 2 0.002 0.0011 0.0185
Trypanosoma brucei heat shock protein, putative 0.0109 0.0289 0.0951
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.006 0.0191
Loa Loa (eye worm) histone methyltransferase 0.0038 0.0067 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0036 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0084 0.0208
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0067 0.0623
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0025 0.0056
Plasmodium falciparum JmjC domain-containing protein, putative 0.0043 0.0084 0.1484
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0037 0.0064 0.0157
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0043 0.0084 0.0269
Loa Loa (eye worm) hypothetical protein 0.0364 0.1079 0.2765
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0032 0.0076
Brugia malayi nuclear hormone receptor 0.0081 0.0202 0.0511
Toxoplasma gondii histone lysine methyltransferase SET1 0.0232 0.0672 0.223
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0224 0.0646 0.0991
Mycobacterium tuberculosis Possible two component sensor kinase 0.002 0.0011 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0025
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0076
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0069 0.0335
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0043 0.0083 0.0124
Schistosoma mansoni coup transcription factor 0.0081 0.0202 0.031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0064 0.0586
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0052 0.0111 0.0108
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0053 0.019
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.0024
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0072 0.0177
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0033 0.0053 0.0941
Brugia malayi regulator of G-protein signaling egl-10 0.0036 0.0063 0.0156
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.002 0.0011 0.0034
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0081 0.0202 0.031
Schistosoma mansoni z-protein (S1r protein) 0.0036 0.0063 0.0097
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.002 0.0011 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0129 0.0198
Toxoplasma gondii histone lysine-specific demethylase 0.0112 0.0298 0.0988
Brugia malayi Poly 0.0986 0.3011 0.7731
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0036 0.0124
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.0064 0.0203
Schistosoma mansoni jumonji domain containing protein 0.0043 0.0084 0.0128
Loa Loa (eye worm) isocitrate dehydrogenase 0.008 0.0198 0.0502
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0011 0.0013
Echinococcus granulosus cathepsin L cysteine protease 0.0021 0.0015 0.0019
Plasmodium falciparum dynamin-like protein 0.0042 0.0081 0.1442
Echinococcus granulosus microtubule associated protein 2 0.211 0.6496 1
Onchocerca volvulus 0.0037 0.0064 0.0309
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0546 0.2047
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0037 0.0064 0.022
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0037 0.0064 0.1128
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0044 0.0041
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0037 0.0064 0.022
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0032 0.0076
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.002 0.0011 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0067 0.0242
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0083 0.0206
Schistosoma mansoni survival motor neuron protein 0.0095 0.0246 0.0377
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0076 0.0277
Brugia malayi nuclear hormone receptor 0.0038 0.0069 0.017
Plasmodium vivax acetyl-CoA synthetase, putative 0.0037 0.0064 0.1127
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.008 0.0199 0.0503
Onchocerca volvulus 0.0041 0.0076 0.0374
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0081 0.0202 0.0199
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0063 0.0145 0.1863
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.002 0.0011 0.0021
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0021
Loa Loa (eye worm) glutaminase 0.0872 0.2657 0.682
Schistosoma mansoni rab6-interacting 0.0039 0.0072 0.011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0036 0.0124
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0021 0.0015 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0076 0.0277
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0069 0.0102
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.0293 0.0447
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0053 0.019
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.0446 0.0683
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0097 0.0356
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.001 0.0032
Loa Loa (eye worm) hypothetical protein 0.0081 0.0202 0.0511
Onchocerca volvulus Huntingtin homolog 0.0364 0.1079 0.5586
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0009 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0202 0.0199
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0064 0.0586
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0053 0.0081
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0017 0.0003 0.000001479
Loa Loa (eye worm) oxidoreductase 0.0037 0.0064 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0076 0.0277
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0075 0.0183 0.06
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0363 0.0559
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0072 0.0106
Trypanosoma brucei Heat shock protein 83, putative 0.0109 0.0289 0.0951
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0037 0.0064 0.022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0225 0.0739
Brugia malayi MH2 domain containing protein 0.0356 0.1055 0.2703
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.001 0.0019
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0064 0.0203
Leishmania major mitochondrial DNA topoisomerase II 0.002 0.0011 0.015
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0064 0.0203
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0083 0.0207
Giardia lamblia Pms1-like protein 0.002 0.0011 0.0011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0067 0.0102
Loa Loa (eye worm) hypothetical protein 0.0081 0.0202 0.0511
Onchocerca volvulus 0.0155 0.0432 0.2224
Echinococcus granulosus Smad4 0.0024 0.0025 0.0035
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Echinococcus multilocularis RUN 0.0039 0.0072 0.0069
Entamoeba histolytica hypothetical protein 0.0439 0.1314 0.4362
Brugia malayi hypothetical protein 0.0102 0.0268 0.0681
Echinococcus granulosus Niemann Pick C1 protein 0.0158 0.044 0.0673
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0129 0.0477
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0037 0.0064 0.162
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.002 0.0011 0.0021
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0081 0.0202 0.1026
Leishmania major cytochrome p450-like protein 0.0018 0.0005 0.0046
Schistosoma mansoni dynamin 0.0042 0.0081 0.0124
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0064 0.022
Echinococcus multilocularis cathepsin L 0.0021 0.0015 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0081 0.0202 0.0511
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.0064 0.023
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0102 0.0255
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0033 0.0151
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0037 0.0064 0.022
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0206
Brugia malayi RNA binding protein 0.0133 0.0363 0.0927
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0003 0.0003
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0032 0.0076
Schistosoma mansoni DNA polymerase eta 0.0019 0.001 0.0015
Onchocerca volvulus Alhambra homolog 0.0031 0.0045 0.0211
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0069 0.0105
Trypanosoma cruzi heat shock protein 85, putative 0.009 0.0228 0.0749
Echinococcus multilocularis tumor protein p63 0.1061 0.3243 0.3241
Leishmania major hypothetical protein, conserved 0.0043 0.0084 0.1489
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.002 0.0011 0.0027
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0129 0.0127
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.017
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0021
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.0029
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.0024
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0009 0.0007
Mycobacterium tuberculosis Probable two component sensor kinase 0.002 0.0011 0.0008
Schistosoma mansoni dynamin 0.0046 0.0091 0.014
Entamoeba histolytica cysteine protease, putative 0.0021 0.0015 0.0048
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0157
Echinococcus granulosus heat shock protein 90 0.009 0.0228 0.0347
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0112 0.0298 0.5303
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0089 0.0227 0.0846
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0009 0.0007
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0017 0.0004 0.0004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0043 0.0083 0.008
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0017 0.0003 0.0003
Plasmodium falciparum cysteine proteinase falcipain 1 0.0021 0.0015 0.026
Brugia malayi ecdysteroid receptor 0.0081 0.0202 0.0511
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0126 0.0342 0.1134
Onchocerca volvulus 0.0041 0.0076 0.0374
Brugia malayi TAR-binding protein 0.0133 0.0363 0.0927
Mycobacterium ulcerans heat shock protein 90 0.0093 0.024 0.0884
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.002 0.0011 0.0031
Schistosoma mansoni polypyrimidine tract binding protein 0.0024 0.0026 0.0039
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0037 0.0064 0.0586
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0025 0.0083
Brugia malayi hypothetical protein 0.0024 0.0026 0.006
Trichomonas vaginalis dynamin, putative 0.0042 0.0081 0.0296
Echinococcus granulosus DNA topoisomerase 2 alpha 0.002 0.0011 0.0013
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.008 0.0198 0.2057
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0067 0.0242
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.0446 0.114
Echinococcus multilocularis protein patched 0.0047 0.0097 0.0094
Trypanosoma brucei protein kinase, putative 0.0058 0.0129 0.0421
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0093 0.0239 0.2504
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0081 0.0202 0.0306
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0009 0.001
Plasmodium falciparum dynamin-like protein 0.0042 0.0081 0.1442
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0036 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0015
Entamoeba histolytica hypothetical protein 0.0104 0.0271 0.09
Loa Loa (eye worm) hypothetical protein 0.0046 0.0092 0.023
Trypanosoma cruzi DNA topoisomerase II, putative 0.002 0.0011 0.0027
Echinococcus granulosus cathepsin L cysteine proteinase 0.0041 0.0076 0.0113
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0202 0.0306
Leishmania major sir2-family protein-like protein 0.0033 0.0053 0.0928
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0093 0.0239 0.7961
Schistosoma mansoni patched 1 0.0047 0.0097 0.0149
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.013 0.0354 0.1323
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0011 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0025
Schistosoma mansoni pyruvate dehydrogenase 0.002 0.0011 0.0016
Trypanosoma brucei glucosidase, putative 0.0035 0.006 0.0191
Schistosoma mansoni RAR-like nuclear receptor 0.0081 0.0202 0.031
Brugia malayi Cathepsin L-like precursor 0.0041 0.0076 0.0189
Brugia malayi hypothetical protein 0.0038 0.0069 0.017
Echinococcus granulosus dynamin 1 protein 0.0042 0.0081 0.0121
Echinococcus granulosus ecdysone induced protein 78C 0.0081 0.0202 0.0306
Loa Loa (eye worm) hypothetical protein 0.0125 0.0337 0.0858
Schistosoma mansoni hypothetical protein 0.0207 0.0594 0.0914
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.001 0.0015
Brugia malayi hypothetical protein 0.0038 0.0069 0.017
Echinococcus granulosus zinc finger protein 0.0026 0.0032 0.0045
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0076
Schistosoma mansoni hypothetical protein 0.086 0.2618 0.403
Echinococcus granulosus cathepsin L 0.0021 0.0015 0.0019
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.006 0.0217
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.013 0.0354 0.1167
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0044 0.0085 0.0281
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0056 0.0124 0.0412
Trypanosoma brucei heat shock protein, putative 0.0109 0.0289 0.0951
Schistosoma mansoni lipoxygenase 0.0102 0.0268 0.0411
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0025
Trichomonas vaginalis dynamin, putative 0.0042 0.0081 0.0296
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0084 0.0208
Toxoplasma gondii ABC1 family protein 0.0038 0.0067 0.0223
Onchocerca volvulus 0.0039 0.0072 0.0351
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0036 0.0124
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.003 0.0045 0.0476
Brugia malayi MH1 domain containing protein 0.0024 0.0025 0.0058
Mycobacterium ulcerans hypothetical protein 0.0038 0.0067 0.0233
Loa Loa (eye worm) hypothetical protein 0.0043 0.0084 0.0208
Echinococcus granulosus FTZ F1 alpha 0.0081 0.0202 0.0306
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0064 0.022
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0253 0.0734 0.2755
Echinococcus granulosus heat shock protein 0.0109 0.0289 0.0441
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0081 0.0202 0.0511
Schistosoma mansoni hypothetical protein 0.0095 0.0246 0.0377
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0198 0.065
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.011 0.0293 0.0745
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0025 0.0035
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0061 0.0058
Schistosoma mansoni lamin 0.008 0.0199 0.0305
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0072 0.1271
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0546 0.2047
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0036 0.0124
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0656 0.1985 0.5093
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0258 0.075 0.1153
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0025 0.0058
Echinococcus granulosus GPCR family 2 0.0207 0.0594 0.0911
Brugia malayi hypothetical protein 0.0019 0.0009 0.0017
Brugia malayi Dynamin 0.0046 0.0091 0.0228
Entamoeba histolytica serine/threonine protein kinase, putative 0.0192 0.0546 0.1812
Echinococcus multilocularis regulator of G protein signaling 7 0.0036 0.0063 0.0061
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.0298 0.0458
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0036 0.0124
Mycobacterium tuberculosis Conserved protein 0.0038 0.0067 0.0623
Echinococcus multilocularis Regulator of differentiation 1 0.0024 0.0026 0.0023
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Brugia malayi Papain family cysteine protease containing protein 0.0021 0.0015 0.0032
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0032 0.0076
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0085 0.0212
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0202 0.0306
Schistosoma mansoni lamin 0.008 0.0199 0.0305
Mycobacterium tuberculosis Conserved hypothetical protein 0.0112 0.0298 0.3143
Loa Loa (eye worm) hypothetical protein 0.004 0.0076 0.0188
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0081 0.0202 0.0511
Onchocerca volvulus 0.0095 0.0246 0.1255
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0125 0.0337 0.125
Loa Loa (eye worm) TOPoisomerase family member 0.002 0.0011 0.0021
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0069 0.0105
Loa Loa (eye worm) hypothetical protein 0.0038 0.0067 0.0165
Entamoeba histolytica DNA topoisomerase II, putative 0.002 0.0011 0.0034
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.002 0.0011 0.0008
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0037 0.0064 0.0094
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0037 0.0064 0.021
Leishmania major cathepsin L-like protease 0.0089 0.0225 0.409
Leishmania major cathepsin L-like protease 0.0041 0.0076 0.1351
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.0064 0.0157
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0067 0.0242
Loa Loa (eye worm) MH2 domain-containing protein 0.0356 0.1055 0.2703
Brugia malayi Intermediate filament tail domain containing protein 0.008 0.0199 0.0503
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0446 0.0444
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0069 0.0105
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.013 0.0354 0.0544
Schistosoma mansoni intermediate filament proteins 0.008 0.0199 0.0305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0225 0.0739
Toxoplasma gondii histone deacetylase SIR2 0.0033 0.0053 0.0177
Brugia malayi transcriptional regulator, Sir2 family protein 0.0033 0.0053 0.013
Entamoeba histolytica cysteine proteinase 1, putative 0.0021 0.0015 0.0048
Onchocerca volvulus 0.0121 0.0327 0.1678
Mycobacterium ulcerans monoamine oxidase 0.0112 0.0298 0.1102
Echinococcus granulosus endoplasmin 0.0093 0.024 0.0365
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.011 0.0293 0.0971
Echinococcus multilocularis cathepsin L cysteine protease 0.0041 0.0076 0.0073
Brugia malayi Latrophilin receptor protein 2 0.0207 0.0594 0.1519
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.013 0.0354 0.1323
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0038 0.0069 0.0066
Loa Loa (eye worm) DIX domain-containing protein 0.0017 0.0004 0.0004
Plasmodium vivax hypothetical protein, conserved 0.002 0.0011 0.0184
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0129 0.2331
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0044 0.0085 0.0311
Onchocerca volvulus Cathepsin L homolog 0.0041 0.0076 0.0374
Brugia malayi Isocitrate dehydrogenase 0.008 0.0198 0.0502
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0067 0.0623
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0036 0.0124
Loa Loa (eye worm) hypothetical protein 0.0112 0.0298 0.0757
Loa Loa (eye worm) sirtuin 4 0.0033 0.0053 0.013
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0017 0.0004 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0064 0.022
Echinococcus granulosus bloom syndrome protein 0.0024 0.0025 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0246 0.0916
Trichomonas vaginalis dynamin, putative 0.0042 0.0081 0.0296
Onchocerca volvulus Protein ultraspiracle homolog 0.0081 0.0202 0.1026
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0069 0.0105
Entamoeba histolytica hypothetical protein 0.0072 0.0173 0.0574
Trypanosoma cruzi cysteine peptidase, putative 0.0089 0.0225 0.0739
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0067 0.0623
Schistosoma mansoni hypothetical protein 0.0207 0.0594 0.0914
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.013 0.0354 0.1323
Mycobacterium ulcerans acyl-CoA synthetase 0.0125 0.0337 0.125
Loa Loa (eye worm) hypothetical protein 0.0081 0.0202 0.0511
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0173 0.0266
Trypanosoma brucei heat shock protein 84, putative 0.0056 0.0124 0.0405
Brugia malayi nuclear receptor NHR-88 0.0081 0.0202 0.0511
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0035 0.0052
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0053 0.0081
Trypanosoma brucei DNA topoisomerase II beta, putative 0.002 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0064 0.022
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.002 0.0011 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0004
Brugia malayi jmjC domain containing protein 0.017 0.0478 0.1222
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Loa Loa (eye worm) phosphatidylinositol 3 0.004 0.0073 0.0181
Mycobacterium ulcerans dehydrogenase 0.0112 0.0298 0.1102
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0017 0.0003 0.00000096064
Leishmania major heat shock protein 83-1 0.0109 0.0289 0.5265
Echinococcus multilocularis lysine specific demethylase 5A 0.0161 0.0451 0.0448
Echinococcus multilocularis musashi 0.008 0.0199 0.0196
Leishmania major DNA topoisomerase ii 0.002 0.0011 0.015
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.002 0.0011 0.0021
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0025 0.0035
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0069 0.0066
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0546 0.2047
Loa Loa (eye worm) hypothetical protein 0.0458 0.137 0.3513
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0044 0.0085 0.0274
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0363 0.0559
Leishmania major UDP-galactopyranose mutase 0.0112 0.0298 0.5424
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0025 0.0083
Loa Loa (eye worm) ctsf protein 0.0041 0.0076 0.0189
Echinococcus granulosus cathepsin l1 0.0027 0.0035 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.0202 0.0511
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0081 0.0202 0.0199
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0069 0.0102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0036 0.0124
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0042 0.0081 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0076 0.0277
Brugia malayi hypothetical protein 0.0467 0.1399 0.3588
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0253 0.0734 0.0731
Trichomonas vaginalis sensor histidine kinase, putative 0.002 0.0011 0.0031
Trichomonas vaginalis heat shock protein, putative 0.0093 0.024 0.0893
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0173 0.0263
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0021 0.0015 0.0022
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.006 0.1058
Loa Loa (eye worm) jmjC domain-containing protein 0.017 0.0478 0.1222
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0037 0.0064 0.0586
Leishmania major DNA polymerase eta, putative 0.0019 0.001 0.0135
Loa Loa (eye worm) intermediate filament protein 0.008 0.0199 0.0503
Mycobacterium ulcerans DNA gyrase subunit B 0.002 0.0011 0.0021
Schistosoma mansoni jumonji domain containing protein 0.0204 0.0583 0.0896
Giardia lamblia Hypothetical protein 0.0033 0.0053 0.0595
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0084 0.0208
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0268 0.4776
Trypanosoma cruzi polypyrimidine tract-binding protein, putative 0.0024 0.0026 0.0077
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0009 0.0017
Schistosoma mansoni heat shock protein 0.0109 0.0289 0.0444
Loa Loa (eye worm) hypothetical protein 0.0458 0.137 0.3513
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0112 0.0298 0.0457
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0005 0.0008
Echinococcus granulosus segment polarity protein dishevelled 0.0017 0.0004 0.0002
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0035 0.0113
Brugia malayi transcriptional regulator, Sir2 family protein 0.0033 0.0053 0.013
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0104 0.0271 0.09
Echinococcus multilocularis microtubule associated protein 2 0.211 0.6496 0.6495
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0125 0.0337 0.125
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0823 0.2503 0.2501
Trypanosoma brucei RNA helicase, putative 0.0384 0.1142 0.3788
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.006 0.0217
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0069 0.0102
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0157
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0081 0.0202 0.0306
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0129 0.0477
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.0024
Entamoeba histolytica cysteine protease, putative 0.0021 0.0015 0.0048
Brugia malayi isocitrate dehydrogenase 0.008 0.0198 0.0502
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0069 0.017
Onchocerca volvulus 0.0026 0.0032 0.0145
Trypanosoma cruzi UDP-galactopyranose mutase 0.0112 0.0298 0.098
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.009 0.0228 0.0347
Loa Loa (eye worm) hypothetical protein 0.0039 0.0072 0.0177
Loa Loa (eye worm) hypothetical protein 0.0102 0.0268 0.0681
Brugia malayi nuclear receptor RXR 0.0043 0.0083 0.0206
Brugia malayi Steroid receptor seven-up type 2 0.0081 0.0202 0.0511
Brugia malayi intermediate filament protein 0.008 0.0199 0.0503
Loa Loa (eye worm) hypothetical protein 0.0084 0.0212 0.0537
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0108
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0033 0.0053 0.0168
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0045 0.0149
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0021
Brugia malayi Cathepsin L-like precursor 0.0027 0.0035 0.0082
Onchocerca volvulus 0.0039 0.0072 0.0351
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0198 0.065
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.008 0.0198 0.065
Schistosoma mansoni nuclear hormone receptor 0.0081 0.0202 0.031
Echinococcus multilocularis cathepsin L cysteine protease 0.0041 0.0076 0.0073
Brugia malayi hypothetical protein 0.0043 0.0083 0.0206
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0009 0.0013
Echinococcus multilocularis Smad4 0.0024 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0364 0.1079 0.2765
Trypanosoma brucei poly(ADP-ribose) glycohydrolase, putative 0.0986 0.3011 1
Loa Loa (eye worm) Smad1 0.0024 0.0025 0.0058
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0081 0.0202 0.0306
Echinococcus granulosus regulator of G protein signaling 7 0.0036 0.0063 0.0093
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1271 0.3894 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0246 0.0916
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0025 0.0058
Toxoplasma gondii heat shock protein 75, putative 0.0056 0.0124 0.0413
Schistosoma mansoni heat shock protein 0.0056 0.0124 0.0191
Schistosoma mansoni amine oxidase 0.0112 0.0298 0.0457
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0129 0.0127
Loa Loa (eye worm) hypothetical protein 0.0038 0.0067 0.0165
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0072 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0024
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0033 0.0053 0.0471
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0043 0.0084 0.0128
Echinococcus granulosus cathepsin l cysteine peptidase 0.0041 0.0076 0.0113
Entamoeba histolytica cysteine protease, putative 0.0021 0.0015 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0036 0.0124
Schistosoma mansoni Smad4 0.0024 0.0025 0.0038
Mycobacterium leprae Probable lipase LipE 0.0038 0.0067 0.1725
Schistosoma mansoni hypothetical protein 0.0072 0.0173 0.0266
Trypanosoma brucei heat shock protein, putative 0.0109 0.0289 0.0951
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0024
Onchocerca volvulus 0.0037 0.0064 0.0309
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0064 0.022
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0044 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0076 0.0277
Loa Loa (eye worm) RNA binding protein 0.0133 0.0363 0.0927
Schistosoma mansoni zinc finger protein 0.0038 0.0069 0.0105
Echinococcus granulosus expressed protein 0.0371 0.1101 0.1691
Onchocerca volvulus DNA topoisomerase 2 homolog 0.002 0.0011 0.0034
Echinococcus multilocularis isocitrate dehydrogenase 0.008 0.0198 0.0195
Schistosoma mansoni hypothetical protein 0.0046 0.0092 0.0141
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.006 0.0198
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0076 0.0251
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0043 0.0084 0.0278
Leishmania major acetyl-CoA synthetase, putative 0.0037 0.0064 0.1121
Leishmania major cathepsin L-like protease 0.0089 0.0225 0.409
Schistosoma mansoni loxhd1 0.0039 0.0072 0.011
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0041 0.0059
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0009 0.0013
Toxoplasma gondii poly(ADP-ribose) glycohydrolase 0.0439 0.1314 0.4363
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0125 0.0337 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0069 0.017
Trypanosoma brucei PAB1-binding protein , putative 0.0102 0.0268 0.0881
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0198 0.0195
Loa Loa (eye worm) latrophilin receptor protein 2 0.0207 0.0594 0.1519

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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