Detailed information for compound 1416203

Basic information

Technical information
  • TDR Targets ID: 1416203
  • Name: (3R,3aR,7aR)-3-[5-(4-acetylphenyl)-2-methoxyp henyl]-7a-methyl-2-(phenylmethyl)-3,3a,6,7-te trahydroisoindol-1-one
  • MW: 465.583 | Formula: C31H31NO3
  • H donors: 0 H acceptors: 2 LogP: 5.43 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1[C@@H]1N(Cc2ccccc2)C(=O)[C@]2([C@H]1C=CCC2)C)c1ccc(cc1)C(=O)C
  • InChi: 1S/C31H31NO3/c1-21(33)23-12-14-24(15-13-23)25-16-17-28(35-3)26(19-25)29-27-11-7-8-18-31(27,2)30(34)32(29)20-22-9-5-4-6-10-22/h4-7,9-17,19,27,29H,8,18,20H2,1-3H3/t27-,29-,31+/m0/s1
  • InChiKey: XKZJGHRUADKFCX-DEDOGFMKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3R,3aR,7aR)-3-[5-(4-acetylphenyl)-2-methoxy-phenyl]-7a-methyl-2-(phenylmethyl)-3,3a,6,7-tetrahydroisoindol-1-one
  • (3R,3aR,7aR)-3-[5-(4-acetylphenyl)-2-methoxy-phenyl]-2-(benzyl)-7a-methyl-3,3a,6,7-tetrahydroisoindol-1-one
  • (3R,3aR,7aR)-3-[5-(4-ethanoylphenyl)-2-methoxy-phenyl]-7a-methyl-2-(phenylmethyl)-3,3a,6,7-tetrahydroisoindol-1-one
  • MLS000882750
  • SMR000465319
  • KUC101260N

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus pyruvate kinase 0.0069 0.0253 0.0253
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0195 0.0842 0.0842
Loa Loa (eye worm) jmjC domain-containing protein 0.0186 0.0802 0.1531
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0017 0.0011 0.0011
Leishmania major DNA polymerase eta, putative 0.0032 0.0078 0.0196
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.004 0.004
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.023 0.044
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0005 0.0005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0006 0.0012
Schistosoma mansoni Smad4 0.0035 0.0091 0.0091
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0016 0.0005 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0263 0.0662
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0017 0.0011 0.002
Treponema pallidum ferredoxin-NADP(+) reductase subunit alpha 0.0098 0.039 0.2638
Leishmania major hypothetical protein, conserved 0.0128 0.053 0.1333
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0074 0.0278 0.0699
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0263 0.1278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0221 0.0555
Onchocerca volvulus Huntingtin homolog 0.0136 0.0565 0.4276
Schistosoma mansoni dishevelled 0.0017 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0163 0.0312
Onchocerca volvulus 0.0024 0.004 0.0302
Loa Loa (eye worm) hypothetical protein 0.015 0.0634 0.121
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0015
Brugia malayi tailless protein 0.0024 0.004 0.0076
Brugia malayi PDZ domain 0.0017 0.0011 0.002
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0263 0.0662
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.004 0.004
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0016 0.0005 0.0009
Echinococcus granulosus TGF beta signal transducer SmadC 0.0077 0.0291 0.0291
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.008 0.0302 0.1559
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0005 0.0009
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0017 0.0011 0.0011
Brugia malayi hypothetical protein 0.0024 0.004 0.0076
Loa Loa (eye worm) inositol-1 0.008 0.0302 0.0577
Brugia malayi hypothetical protein 0.0026 0.0053 0.0102
Echinococcus multilocularis snurportin 1 0.0636 0.2911 0.2911
Loa Loa (eye worm) hypothetical protein 0.005 0.0163 0.0312
Trichomonas vaginalis glutaminase, putative 0.0268 0.1186 0.298
Treponema pallidum flavodoxin 0.0331 0.1478 1
Mycobacterium ulcerans beta-lactamase 0.0071 0.0263 0.0614
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0195 0.0842 0.0842
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0098 0.039 0.098
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0102
Echinococcus multilocularis muscleblind protein 1 0.015 0.0634 0.0634
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0017 0.0011 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0006 0.0006
Brugia malayi jmjC domain containing protein 0.0049 0.016 0.0306
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0163 0.0312
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0096 0.0242
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0021 0.01
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0017 0.0011 0.0011
Mycobacterium ulcerans lipase LipD 0.0071 0.0263 0.0614
Loa Loa (eye worm) hypothetical protein 0.006 0.0209 0.0399
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0209 0.0525
Loa Loa (eye worm) guanylate kinase 0.0017 0.0011 0.002
Plasmodium falciparum pyruvate kinase 2 0.0069 0.0253 0.0636
Loa Loa (eye worm) Smad1 0.0077 0.0291 0.0556
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0011
Echinococcus granulosus pdz domain containing protein 0.0017 0.0011 0.0011
Loa Loa (eye worm) nuclear factor I 0.0043 0.013 0.0248
Giardia lamblia Flavohemoprotein lateral transfer candidate 0.0098 0.039 0.1108
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0372 0.0936
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0006 0.0046
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0098 0.039 0.098
Onchocerca volvulus 0.0018 0.0012 0.0092
Leishmania major GTP-binding protein, putative 0.0044 0.0135 0.034
Toxoplasma gondii cathepsin CPL 0.0016 0.0006 0.0031
Echinococcus granulosus mothers against decapentaplegic 2 0.0035 0.0091 0.0091
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0053 0.0102
Brugia malayi Doublecortin family protein 0.002 0.0024 0.0046
Echinococcus multilocularis RUN 0.002 0.0024 0.0024
Brugia malayi PDZ domain containing protein 0.0017 0.0011 0.002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.0302 0.076
Echinococcus granulosus tar DNA binding protein 0.0064 0.023 0.023
Echinococcus granulosus RUN 0.002 0.0024 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0263 0.0662
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.007 0.0361
Mycobacterium ulcerans hypothetical protein 0.0071 0.0263 0.0614
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0163 0.0163
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0331 0.1478 0.3716
Echinococcus granulosus smad 0.0077 0.0291 0.0291
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0076 0.0145
Echinococcus multilocularis glutamate receptor interacting protein 1 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.005 0.0164 0.0314
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0163 0.0163
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0302 0.076
Loa Loa (eye worm) RNA binding protein 0.0064 0.023 0.044
Leishmania major cathepsin L-like protease 0.0062 0.0221 0.0555
Loa Loa (eye worm) hypothetical protein 0.0042 0.0126 0.024
Schistosoma mansoni hypothetical protein 0.002 0.0024 0.0024
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0076
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0126 0.0126
Brugia malayi Smad1 0.0077 0.0291 0.0556
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0046
Leishmania major reductase, putative 0.0098 0.039 0.098
Schistosoma mansoni pyruvate kinase 0.0134 0.0559 0.0559
Brugia malayi steroid hormone receptor 0.005 0.0163 0.0312
Schistosoma mansoni tar DNA-binding protein 0.0064 0.023 0.023
Brugia malayi Pre-SET motif family protein 0.003 0.007 0.0134
Echinococcus multilocularis microtubule associated serine:threonine protein 0.0018 0.0012 0.0012
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0017 0.0011 0.0011
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0156 0.0392
Plasmodium falciparum ataxin-2 like protein, putative 0.0128 0.053 0.1333
Echinococcus multilocularis thyroid hormone receptor alpha 0.005 0.0163 0.0163
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0163 0.0163
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0049 0.016 0.0403
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0163 0.0163
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0864 0.3978 1
Loa Loa (eye worm) cysteine protease 0.0016 0.0006 0.0012
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.029 0.1289 0.1289
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0074 0.0278 0.0531
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.004 0.0076
Schistosoma mansoni pdz and lim domain protein 0.0017 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0011
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0005 0.0005
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0015
Onchocerca volvulus 0.0017 0.0011 0.0081
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0076
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0082 0.0556
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0263 0.0263
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.007 0.007
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.004 0.0076
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.004 0.004
Brugia malayi MH2 domain containing protein 0.1133 0.5238 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0076
Echinococcus granulosus jumonji domain containing 1A 0.0049 0.016 0.016
Leishmania major NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0017 0.0011 0.0011
Onchocerca volvulus Pyruvate kinase homolog 0.0134 0.0559 0.4232
Echinococcus multilocularis lysine specific demethylase 5A 0.0184 0.0794 0.0794
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0017 0.0011 0.0011
Schistosoma mansoni leucine-rich repeat protein 0.0017 0.0011 0.0011
Echinococcus multilocularis lysine specific demethylase 6a 0.0049 0.016 0.016
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0263 0.1278
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0135 0.0258
Brugia malayi nuclear receptor RXR 0.0024 0.004 0.0076
Onchocerca volvulus 0.002 0.0024 0.0182
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0011 0.0011
Plasmodium falciparum pyruvate kinase 0.0134 0.0559 0.1406
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0163 0.1237
Echinococcus multilocularis mothers against decapentaplegic 6 0.0035 0.0091 0.0091
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0163 0.0163
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0221 0.0555
Onchocerca volvulus 0.0016 0.0006 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0221 0.0555
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0126 0.024
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0195 0.0842 0.1607
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0135 0.0384
Echinococcus multilocularis muscleblind protein 0.015 0.0634 0.0634
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.007 0.007
Loa Loa (eye worm) pyruvate kinase 0.0134 0.0559 0.1068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.007 0.007
Echinococcus multilocularis tar DNA binding protein 0.0064 0.023 0.023
Trichomonas vaginalis bromodomain-containing protein, putative 0.0085 0.0329 0.0828
Entamoeba histolytica type A flavoprotein, putative 0.0331 0.1478 1
Loa Loa (eye worm) hypothetical protein 0.0615 0.2813 0.537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0221 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0163 0.0312
Echinococcus multilocularis smad 0.0077 0.0291 0.0291
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0006 0.0015
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0017 0.0011 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0382 0.096
Schistosoma mansoni hypothetical protein 0.0058 0.0199 0.0199
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0021 0.0052
Leishmania major cytochrome-b5 reductase, putative 0.0098 0.039 0.098
Schistosoma mansoni syntrophin 0.0017 0.0011 0.0011
Loa Loa (eye worm) DR-78 0.0024 0.004 0.0076
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0074 0.0278 0.1348
Echinococcus granulosus pyruvate kinase 0.0134 0.0559 0.0559
Echinococcus granulosus Microtubule-associated serine/threonine-protein kinase 0.0018 0.0012 0.0012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0163 0.0163
Echinococcus granulosus pyruvate kinase 0.0069 0.0253 0.0253
Trypanosoma cruzi pyruvate kinase 2, putative 0.0134 0.0559 0.1406
Schistosoma mansoni MAGUK homolog 0.0018 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0098 0.039 0.2012
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0005 0.0005
Schistosoma mansoni nuclear hormone receptor 0.0024 0.004 0.004
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0021 0.0052
Loa Loa (eye worm) TAR-binding protein 0.0064 0.023 0.044
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0051 0.0168 0.0168
Onchocerca volvulus 0.0016 0.0006 0.0046
Giardia lamblia Hypothetical protein 0.0766 0.3518 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.008 0.0201
Onchocerca volvulus 0.0016 0.0006 0.0046
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.015 0.0634 0.121
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0164 0.0164
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0006 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0382 0.0382
Echinococcus multilocularis cell polarity protein leucine rich repeat 0.0017 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0015
Brugia malayi DIX domain containing protein 0.0017 0.0011 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0221 0.0555
Loa Loa (eye worm) glutaminase 0.0268 0.1186 0.2264
Onchocerca volvulus 0.0017 0.0011 0.0081
Leishmania major cytochrome-b5 reductase, putative 0.0098 0.039 0.098
Entamoeba histolytica myo-inositol monophosphatase, putative 0.008 0.0302 0.2045
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Loa Loa (eye worm) hypothetical protein 0.0136 0.0565 0.1079
Brugia malayi jmjC domain containing protein 0.0049 0.016 0.0306
Brugia malayi hypothetical protein 0.0017 0.0011 0.002
Echinococcus multilocularis dna polymerase eta 0.0045 0.014 0.014
Mycobacterium tuberculosis Conserved protein 0.0071 0.0263 0.1278
Echinococcus granulosus geminin 0.1047 0.4833 0.4833
Schistosoma mansoni ran 0.0044 0.0135 0.0135
Brugia malayi Nuclear hormone receptor E75 0.0024 0.004 0.0076
Onchocerca volvulus 0.002 0.0024 0.0182
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0302 0.076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0015
Schistosoma mansoni smad1 5 8 and 0.0077 0.0291 0.0291
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0382 0.0382
Echinococcus granulosus tumor protein p63 0.0342 0.1533 0.1533
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0049 0.016 0.0826
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.016 0.0306
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0263 0.0614
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0864 0.3978 0.7595
Entamoeba histolytica hypothetical protein 0.0048 0.0156 0.1056
Schistosoma mansoni coup transcription factor 0.005 0.0163 0.0163
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0263 0.0662
Schistosoma mansoni smad 0.0035 0.0091 0.0091
Echinococcus multilocularis 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0221 0.0555
Echinococcus multilocularis pdz domain containing protein 0.0017 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0418 0.1888 0.1888
Echinococcus granulosus partitioning defective 3 0.0017 0.0011 0.0011
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0005 0.0012
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0096 0.0242
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.004 0.004
Schistosoma mansoni cytochrome B5 0.0098 0.039 0.039
Loa Loa (eye worm) flavodoxin family protein 0.0331 0.1478 0.2822
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0126 0.085
Brugia malayi Calcitonin receptor-like protein seb-1 0.0615 0.2813 0.537
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0374 0.1681 0.1681
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0017 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0421 0.19 0.3628
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.0053 0.0053
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0005 0.0009
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.005 0.0163 0.0312
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0021 0.0021
Entamoeba histolytica acetyltransferase, GNAT family 0.0078 0.0296 0.2003
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0005 0.0005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0374 0.1681 0.3209
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0382 0.096
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0098 0.039 0.098
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0163 0.0163
Brugia malayi MH1 domain containing protein 0.0077 0.0291 0.0556
Echinococcus multilocularis lamin 0.0031 0.0076 0.0076
Brugia malayi interleukin-16 0.0017 0.0011 0.002
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0098 0.039 0.0933
Trypanosoma brucei nitrate reductase, putative 0.0098 0.039 0.098
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0263 0.0503
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0195 0.0842 0.0842
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0096 0.0496
Schistosoma mansoni hypothetical protein 0.0195 0.0842 0.0842
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0098 0.039 0.039
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0011
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0096 0.0096
Echinococcus granulosus histone acetyltransferase KAT2B 0.0282 0.1251 0.1251
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0011
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.023 0.044
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.3613 0.3613
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0864 0.3978 1
Entamoeba histolytica type A flavoprotein, putative 0.0331 0.1478 1
Onchocerca volvulus Huntingtin homolog 0.0136 0.0565 0.4276
Brugia malayi Syntrophin-1 0.0017 0.0011 0.002
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0005 0.0012
Trypanosoma cruzi reductase, putative 0.0098 0.039 0.098
Entamoeba histolytica hypothetical protein 0.0073 0.0271 0.1834
Brugia malayi jmjC domain containing protein 0.0184 0.0794 0.1516
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0084 0.0159
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0098 0.039 0.098
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0163 0.0163
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.008 0.0302 0.2583
Trypanosoma brucei oxidoreductase-protein, putative 0.0098 0.039 0.098
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Echinococcus multilocularis Rho GTPase activating protein 21 0.0017 0.0011 0.0011
Loa Loa (eye worm) AGC/MAST/MAST protein kinase 0.0018 0.0012 0.0023
Schistosoma mansoni microtubule-associated protein tau 0.2149 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Schistosoma mansoni rab6-interacting 0.002 0.0024 0.0024
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0126 0.0126
Echinococcus granulosus dna polymerase eta 0.0045 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0012
Loa Loa (eye worm) FAD binding domain-containing protein 0.0864 0.3978 0.7595
Loa Loa (eye worm) PDZ-domain-containing protein scribble 0.0017 0.0011 0.002
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0016 0.0005 0.0005
Brugia malayi 9ORF binding protein 1 0.0017 0.0011 0.002
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0098 0.039 0.098
Brugia malayi hypothetical protein 0.0017 0.0011 0.002
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.0053 0.0053
Echinococcus multilocularis multiple pdz domain protein 0.0017 0.0011 0.0011
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0135 0.034
Brugia malayi RNA, U transporter 1 0.0169 0.0724 0.1382
Echinococcus multilocularis amyloid beta A4 protein 0.0017 0.0011 0.0011
Brugia malayi Importin beta-1 subunit 0.006 0.0209 0.0399
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0158 0.0398
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0096 0.0242
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0331 0.1478 0.3716
Echinococcus granulosus cpg binding protein 0.0031 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0864 0.3978 1
Giardia lamblia Pyruvate kinase 0.0134 0.0559 0.159
Echinococcus granulosus beta 1 syntrophin 0.0017 0.0011 0.0011
Schistosoma mansoni sh3 and multiple ankyrin repeat domains protein 12 (shank12) 0.0017 0.0011 0.0011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0074 0.0278 0.0278
Echinococcus granulosus tight junction protein ZO 3 0.0017 0.0011 0.0011
Brugia malayi Hypothetical 13.5 kDa protein C45G9.7 in chromosome III 0.0017 0.0011 0.002
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Brugia malayi Pre-SET motif family protein 0.0205 0.0889 0.1698
Brugia malayi hypothetical protein 0.0026 0.0053 0.0102
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0016 0.0005 0.0012
Echinococcus granulosus multiple pdz domain protein 0.0017 0.0011 0.0011
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0012
Schistosoma mansoni intermediate filament proteins 0.0031 0.0076 0.0076
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0163 0.0163
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0082 0.0206
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0021 0.0052
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0121 0.0494 0.0494
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0263 0.0662
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0331 0.1478 0.3716
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.004 0.004
Brugia malayi MH1 domain containing protein 0.0043 0.013 0.0248
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0174
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0074 0.0278 0.0699
Onchocerca volvulus 0.005 0.0163 0.1237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Onchocerca volvulus 0.0017 0.0011 0.0081
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0053 0.0102
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0018 0.0012 0.0012
Loa Loa (eye worm) X11 protein 0.0017 0.0011 0.002
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0076
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0074 0.0278 0.0278
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0382 0.0729
Entamoeba histolytica hypothetical protein 0.0073 0.0271 0.1834
Echinococcus multilocularis mothers against decapentaplegic 5 0.0077 0.0291 0.0291
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0263 0.1278
Brugia malayi MH2 domain containing protein 0.0035 0.0091 0.0174
Onchocerca volvulus 0.0297 0.1321 1
Entamoeba histolytica hypothetical protein 0.0073 0.0271 0.1834
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0051 0.0168 0.0168
Brugia malayi Synapse defective protein 1 0.0017 0.0011 0.002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0302 0.076
Brugia malayi RasGEF domain containing protein 0.0017 0.0011 0.002
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0098 0.039 0.098
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0163 0.0312
Schistosoma mansoni syntenin 0.0017 0.0011 0.0011
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.004 0.004
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.022 0.022
Brugia malayi Shank2E 0.0017 0.0011 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0015
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0017 0.0011 0.0011
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0163 0.0312
Trypanosoma brucei PAB1-binding protein , putative 0.0128 0.053 0.1333
Trypanosoma cruzi PAB1-binding protein , putative 0.0128 0.053 0.1333
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0085 0.0329 0.1699
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0615 0.2813 0.537
Echinococcus granulosus lysine specific demethylase 5A 0.0186 0.0802 0.0802
Trypanosoma cruzi PAB1-binding protein , putative 0.0128 0.053 0.1333
Brugia malayi beta-lactamase 0.0071 0.0263 0.0503
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0263 0.38
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0374 0.1681 0.1681
Schistosoma mansoni hypothetical protein 0.0279 0.1238 0.1238
Toxoplasma gondii exonuclease III APE 0.0074 0.0278 0.1434
Brugia malayi C2 domain containing protein 0.0017 0.0011 0.002
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.004 0.004
Brugia malayi hypothetical protein 0.0136 0.0565 0.1079
Entamoeba histolytica cysteine protease, putative 0.0016 0.0006 0.0041
Schistosoma mansoni afadin (af-6 protein) 0.0017 0.0011 0.0011
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0017 0.0011 0.0011
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0067 0.0128
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0076
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0017 0.0011 0.0011
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0263 0.1278
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0006 0.0006
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0096 0.0096
Trichomonas vaginalis sulfite reductase, putative 0.0864 0.3978 1
Schistosoma mansoni amyloid beta A4 protein related 0.0017 0.0011 0.0011
Brugia malayi RNA binding protein 0.0064 0.023 0.044
Schistosoma mansoni nuclear hormone receptor 0.0024 0.004 0.004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0263 0.1278
Echinococcus multilocularis jumonji domain containing 1A 0.0049 0.016 0.016
Onchocerca volvulus 0.0071 0.0263 0.1993
Echinococcus granulosus cathepsin l1 0.0016 0.0006 0.0006
Loa Loa (eye worm) pyruvate kinase 0.0028 0.0062 0.0119
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.0053 0.0053
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0864 0.3978 0.3978
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0374 0.1681 0.1681
Toxoplasma gondii hypothetical protein 0.0033 0.0082 0.0424
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0024 0.0061
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0017 0.0011 0.0011
Entamoeba histolytica type A flavoprotein, putative 0.0331 0.1478 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0017 0.0011 0.0011
Echinococcus multilocularis pyruvate kinase 0.0069 0.0253 0.0253
Brugia malayi hypothetical protein 0.0017 0.0011 0.002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0226 0.0226
Echinococcus granulosus phd:f box containing protein 0.0049 0.016 0.016
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0098 0.039 0.098
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0156 0.0392
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.004 0.004
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0534 0.2429 0.2429
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.008 0.0201
Schistosoma mansoni kinase 0.0049 0.016 0.016
Echinococcus multilocularis ligand of numb protein x 2 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0094 0.0372 0.0711
Echinococcus multilocularis neurabin 1 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0076
Loa Loa (eye worm) hypothetical protein 0.0094 0.0369 0.0704
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0015
Schistosoma mansoni multiple pdz domain protein 0.0017 0.0011 0.0011
Brugia malayi diaphorase 0.0098 0.039 0.0744
Schistosoma mansoni jumonji/arid domain-containing protein 0.0186 0.0802 0.0802
Schistosoma mansoni cytochrome P450 reductase 0.0864 0.3978 0.3978
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0263 0.0263
Loa Loa (eye worm) fibroinase 0.0016 0.0006 0.0012
Brugia malayi rho guanine nucleotide exchange factor 12 0.0017 0.0011 0.002
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Schistosoma mansoni hypothetical protein 0.0195 0.0842 0.0842
Loa Loa (eye worm) hypothetical protein 0.003 0.007 0.0134
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0864 0.3978 1
Giardia lamblia Nitric oxide synthase, inducible 0.0766 0.3518 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0163 0.0163
Loa Loa (eye worm) diaphorase 0.0098 0.039 0.0744
Schistosoma mansoni tar DNA-binding protein 0.0064 0.023 0.023
Brugia malayi pyruvate kinase 0.0028 0.0062 0.0119
Schistosoma mansoni alpha-glucosidase 0.0138 0.0576 0.0576
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0163 0.0312
Loa Loa (eye worm) hypothetical protein 0.0071 0.0263 0.0503
Brugia malayi CXXC zinc finger family protein 0.0029 0.0067 0.0128
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0098 0.039 0.0744
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0221 0.0555
Plasmodium vivax pyruvate kinase 2, putative 0.0069 0.0253 0.0636
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0005 0.0012
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0005 0.0005
Echinococcus granulosus lamin 0.0031 0.0076 0.0076
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0006 0.0015
Schistosoma mansoni phosphatidylserine receptor 0.0049 0.016 0.016
Onchocerca volvulus 0.0017 0.0011 0.0081
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0126 0.0316
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0209 0.1078
Brugia malayi jmjC domain containing protein 0.0186 0.0802 0.1531
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0382 0.096
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0098 0.039 0.098
Echinococcus multilocularis protein lin 7 B 0.0017 0.0011 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0374 0.1681 0.1681
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0154 0.0386
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0085 0.0329 0.1699
Leishmania major hypothetical protein, conserved 0.0331 0.1478 0.3716
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.014 0.0268
Echinococcus granulosus ligand of numb protein x 2 0.0017 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0015
Brugia malayi ecdysteroid receptor 0.005 0.0163 0.0312
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Schistosoma mansoni cpg binding protein 0.0031 0.0075 0.0075
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Echinococcus multilocularis expressed protein 0.0016 0.0005 0.0005
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0331 0.1478 0.3716
Echinococcus granulosus amyloid beta A4 protein 0.0017 0.0011 0.0011
Echinococcus granulosus neuropeptide receptor A26 0.0569 0.2596 0.2596
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0016 0.0005 0.0009
Toxoplasma gondii flavodoxin domain-containing protein 0.0429 0.1938 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0331 0.1478 0.3716
Toxoplasma gondii pyruvate kinase PyK1 0.0134 0.0559 0.2885
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0058 0.0199 0.0199
Echinococcus multilocularis geminin 0.1047 0.4833 0.4833
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0071 0.0263 0.0503
Mycobacterium tuberculosis Conserved protein 0.0071 0.0263 0.1278
Plasmodium vivax flavodoxin domain containing protein 0.0766 0.3518 0.8843
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0382 0.0729
Schistosoma mansoni multiple pdz domain protein 0.0017 0.0011 0.0011
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0016 0.0005 0.0009
Mycobacterium tuberculosis Possible oxygenase 0.0098 0.039 0.1891
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Echinococcus granulosus importin subunit beta 1 0.006 0.0209 0.0209
Brugia malayi latrophilin 2 splice variant baaae 0.0421 0.19 0.3628
Schistosoma mansoni alpha-glucosidase 0.0138 0.0576 0.0576
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0006 0.0006
Schistosoma mansoni loxhd1 0.002 0.0024 0.0024
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0021 0.0039
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0016 0.0005 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0163 0.0312
Echinococcus granulosus FTZ F1 alpha 0.005 0.0163 0.0163
Schistosoma mansoni NADPH flavin oxidoreductase 0.0435 0.1969 0.1969
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0009
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0017 0.0011 0.0011
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0005 0.0005
Mycobacterium tuberculosis Probable monooxygenase 0.0098 0.039 0.1891
Echinococcus granulosus pdz domain containing protein 0.0017 0.0011 0.0011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0186 0.0802 0.0802
Trypanosoma brucei pyruvate kinase 1 0.0134 0.0559 0.1406
Echinococcus multilocularis phd:f box containing protein 0.0049 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Schistosoma mansoni discs lost-related 0.0017 0.0011 0.0011
Brugia malayi jmjC domain containing protein 0.0049 0.016 0.0306
Onchocerca volvulus 0.0031 0.0076 0.0575
Brugia malayi PDZ-domain protein scribble 0.0017 0.0011 0.002
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0006 0.0046
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Brugia malayi FAD binding domain containing protein 0.0864 0.3978 0.7595
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0195 0.0491
Leishmania major NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0018 0.0012 0.0012
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0263 0.1278
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0071 0.0263 0.3795
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0011
Schistosoma mansoni multiple pdz domain protein 0.0017 0.0011 0.0011
Loa Loa (eye worm) acetyltransferase 0.029 0.1289 0.2461
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.005 0.0163 0.0312
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0163 0.0163
Trichomonas vaginalis inositol monophosphatase, putative 0.008 0.0302 0.076
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.014 0.0353
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0163 0.0163
Schistosoma mansoni multiple pdz domain protein 0.0017 0.0011 0.0011
Leishmania major pyruvate kinase 0.0134 0.0559 0.1406
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0331 0.1478 0.3716
Onchocerca volvulus 0.003 0.007 0.0529
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0005 0.0005
Echinococcus multilocularis pyruvate kinase 0.0106 0.0427 0.0427
Brugia malayi hypothetical protein 0.0017 0.0011 0.002
Mycobacterium ulcerans pyruvate kinase 0.0134 0.0559 0.1361
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0263 0.0263
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0372 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0135 0.034
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0012
Entamoeba histolytica type A flavoprotein, putative 0.0331 0.1478 1
Schistosoma mansoni multiple pdz domain protein 0.0017 0.0011 0.0011
Toxoplasma gondii LsmAD domain-containing protein 0.0128 0.053 0.2736
Echinococcus granulosus disks large 3 0.0017 0.0011 0.0011
Echinococcus granulosus methionine synthase reductase 0.0534 0.2429 0.2429
Leishmania major hypothetical protein, conserved 0.0049 0.016 0.0403
Echinococcus granulosus neurabin 1 0.0017 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0011
Brugia malayi microtubule-associated serine/threonine protein kinase 2 (MAST2) 0.0017 0.0011 0.002
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0035 0.0091 0.0691
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0098 0.039 0.0933
Plasmodium falciparum ferredoxin--NADP reductase 0.0098 0.039 0.098
Loa Loa (eye worm) 9ORF binding protein 1 0.0017 0.0011 0.002
Echinococcus granulosus Partitioning defective 3 protein B 0.0017 0.0011 0.0011
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.004 0.004
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0005 0.0005
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0077 0.0291 0.0291
Echinococcus multilocularis musashi 0.0031 0.0076 0.0076
Echinococcus multilocularis MAGUK p55 subfamily 0.0017 0.0011 0.0011
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0098 0.039 0.098
Brugia malayi Ferm domain 0.0017 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0297 0.1321 0.2523
Leishmania major NADH-dependent fumarate reductase-like protein 0.0098 0.039 0.098
Trichomonas vaginalis ran, putative 0.0044 0.0135 0.034
Brugia malayi nuclear hormone receptor 0.005 0.0163 0.0312
Brugia malayi PX domain containing protein 0.0017 0.0011 0.002
Echinococcus granulosus myeloid:lymphoid or mixed lineage leukemia 0.0017 0.0011 0.0011
Schistosoma mansoni dishevelled 0.0017 0.0011 0.0011
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0098 0.039 0.098
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0005 0.0005
Echinococcus granulosus PRKCA binding protein 0.0017 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0011
Echinococcus granulosus pyruvate kinase 0.0069 0.0253 0.0253
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0372 0.6079
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0024 0.0061
Brugia malayi Guanylate kinase family protein 0.0017 0.0011 0.002
Trypanosoma brucei pyruvate kinase 1, putative 0.0134 0.0559 0.1406
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0864 0.3978 1
Chlamydia trachomatis pyruvate kinase 0.0134 0.0559 0.2268
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0382 0.096
Schistosoma mansoni hypothetical protein 0.0073 0.0271 0.0271
Brugia malayi hypothetical protein 0.0128 0.053 0.1013
Echinococcus multilocularis MAGUK p55 subfamily 0.0017 0.0011 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0091 0.0174
Onchocerca volvulus 0.0017 0.0011 0.0081
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0021 0.0021
Onchocerca volvulus 0.0017 0.0011 0.0081
Brugia malayi hypothetical protein 0.0017 0.0011 0.002
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0017 0.0011 0.0011
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0017 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0221 0.0555
Schistosoma mansoni cell polarity protein 0.0017 0.0011 0.0011
Brugia malayi Inositol-1 0.008 0.0302 0.0577
Echinococcus multilocularis tight junction protein ZO 3 0.0017 0.0011 0.0011
Brugia malayi Patj homolog 0.0017 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0009
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0006 0.0006
Schistosoma mansoni ap endonuclease 0.0074 0.0278 0.0278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0221 0.0555
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.068 0.1298
Brugia malayi beta-lactamase family protein 0.0071 0.0263 0.0503
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0015
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.022 0.2884
Echinococcus granulosus MAGUK p55 subfamily 0.0017 0.0011 0.0011
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.004 0.0302
Trichomonas vaginalis ap endonuclease, putative 0.0074 0.0278 0.0699
Echinococcus multilocularis rho guanine nucleotide exchange factor 12 0.0017 0.0011 0.0011
Brugia malayi nuclear receptor NHR-88 0.0024 0.004 0.0076
Loa Loa (eye worm) doublecortin family protein 0.002 0.0024 0.0046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0374 0.1681 0.1681
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0163 0.0163
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0331 0.1478 0.3716
Onchocerca volvulus 0.0016 0.0006 0.0046
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0024 0.0024
Brugia malayi ecdysone receptor 0.0024 0.004 0.0076
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.004 0.004
Trichomonas vaginalis pyruvate kinase, putative 0.0134 0.0559 0.1406
Echinococcus granulosus multiple pdz domain protein 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0248
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.004 0.0076
Schistosoma mansoni lipoxygenase 0.0121 0.0494 0.0494
Echinococcus multilocularis multiple pdz domain protein 0.0017 0.0011 0.0011
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0372 0.2518
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0016 0.0005 0.0005
Onchocerca volvulus 0.0016 0.0005 0.0037
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0331 0.1478 0.3716
Echinococcus multilocularis methionine synthase reductase 0.0534 0.2429 0.2429
Schistosoma mansoni Patj homolog 0.0017 0.0011 0.0011
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0049 0.016 0.0826
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Brugia malayi beta-lactamase family protein 0.0071 0.0263 0.0503
Leishmania major nitrate reductase, putative 0.0098 0.039 0.098
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0096 0.0184
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0372 0.1494
Schistosoma mansoni pyruvate kinase 0.0069 0.0253 0.0253
Brugia malayi G-protein alpha subunit 0.0016 0.0005 0.0009
Trichomonas vaginalis rotamase, putative 0.0032 0.008 0.0201
Loa Loa (eye worm) pyruvate kinase 0.0134 0.0559 0.1068
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0024 0.0024
Brugia malayi nuclear receptor NHR-88 0.005 0.0163 0.0312
Plasmodium vivax pyruvate kinase, putative 0.0134 0.0559 0.1406
Loa Loa (eye worm) DIX domain-containing protein 0.0017 0.0011 0.002
Echinococcus multilocularis MAGUK p55 subfamily 0.0017 0.0011 0.0011
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0372 0.0888
Echinococcus multilocularis cysteine protease 0.0016 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0163 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0126 0.0316
Echinococcus granulosus dnaJ subfamily B 0.0418 0.1888 0.1888
Schistosoma mansoni smad1 5 8 and 0.0077 0.0291 0.0291
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0163 0.0163
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0163 0.0163
Echinococcus granulosus pdz domain containing protein 0.0017 0.0011 0.0011
Schistosoma mansoni jumonji domain containing protein 0.0184 0.0794 0.0794
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0163 0.0312
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0074 0.0278 0.0699
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0091 0.0174
Treponema pallidum exodeoxyribonuclease (exoA) 0.0074 0.0278 0.188
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Onchocerca volvulus 0.0093 0.0364 0.2752
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0864 0.3978 1
Brugia malayi protein kinase C-binding protein PICK1 0.0017 0.0011 0.002
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0049 0.016 0.0306
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0084 0.021
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0864 0.3978 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0021 0.0052
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0098 0.039 0.0744
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Echinococcus granulosus inositol monophosphatase 1 0.008 0.0302 0.0302
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0163 0.0312
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0156 0.0392
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0263 0.0662
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0008 0.0015
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0302 0.076
Echinococcus multilocularis inositol monophosphatase 1 0.008 0.0302 0.0302
Toxoplasma gondii ABC1 family protein 0.0071 0.0263 0.1359
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Echinococcus granulosus MAGUK p55 subfamily 0.0017 0.0011 0.0011
Echinococcus granulosus expressed protein 0.0033 0.0084 0.0084
Echinococcus granulosus lysine specific demethylase 6a 0.0049 0.016 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0062 0.0062
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0017 0.0011 0.0081
Leishmania major cytochrome P450 reductase, putative 0.0766 0.3518 0.8843
Onchocerca volvulus 0.005 0.0164 0.1244
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0098 0.039 0.098
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Leishmania major hypothetical protein, conserved 0.0071 0.0263 0.0662
Echinococcus multilocularis mothers against decapentaplegic 2 0.0035 0.0091 0.0091
Plasmodium vivax ataxin-2 like protein, putative 0.0128 0.053 0.1333
Onchocerca volvulus 0.0029 0.0067 0.0508
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0126 0.0126
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0017 0.0011 0.0011
Echinococcus multilocularis cysteine protease 0.0016 0.0006 0.0006
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0076 0.0145
Schistosoma mansoni tar DNA-binding protein 0.0064 0.023 0.023
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Schistosoma mansoni maguk P55 subfamily member 35 0.0017 0.0011 0.0011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0271 0.0271
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0382 0.096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.007 0.007
Schistosoma mansoni protein kinase C alpha binding protein 0.0017 0.0011 0.0011
Mycobacterium ulcerans monooxygenase 0.0098 0.039 0.0933
Echinococcus granulosus neuropeptide s receptor 0.0569 0.2596 0.2596
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0017 0.0011 0.0011
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0163 0.0163
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0053 0.0053
Brugia malayi Neurabin protein 1 0.0017 0.0011 0.002
Echinococcus multilocularis pdz domain containing protein 0.0017 0.0011 0.0011
Schistosoma mansoni glutaminase 0.0268 0.1186 0.1186
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0096 0.0242
Schistosoma mansoni rab6-interacting 0.002 0.0024 0.0024
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.014 0.0353
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0006 0.0041
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0017 0.0011 0.002
Leishmania major cathepsin L-like protease 0.0062 0.0221 0.0555
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0372 0.192
Schistosoma mansoni leucine-rich repeat protein 0.0017 0.0011 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0154 0.0386
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0017 0.0011 0.0011
Echinococcus multilocularis myeloid:lymphoid or mixed lineage leukemia 0.0017 0.0011 0.0011
Toxoplasma gondii pyruvate kinase PyKII 0.0069 0.0253 0.1304
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0382 0.096
Echinococcus multilocularis syndecan binding protein (syntenin) 0.0017 0.0011 0.0011
Giardia lamblia Histone acetyltransferase GCN5 0.0078 0.0296 0.0842
Entamoeba histolytica hypothetical protein 0.0073 0.0271 0.1834
Loa Loa (eye worm) hypothetical protein 0.005 0.0163 0.0312
Brugia malayi gopc protein 0.0017 0.0011 0.002
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0006 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0015
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.007 0.007
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Echinococcus multilocularis disks large 1 0.0017 0.0011 0.0011
Plasmodium falciparum JmjC domain-containing protein, putative 0.0049 0.016 0.0403
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0163 0.0163
Echinococcus granulosus mothers against decapentaplegic 5 0.0077 0.0291 0.0291
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0163 0.0163
Echinococcus multilocularis PDZ domain containing protein GIPC3 0.0017 0.0011 0.0011
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0017 0.0011 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0096 0.0242
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0017 0.0011 0.0011
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0096 0.0184
Schistosoma mansoni alpha glucosidase 0.0036 0.0096 0.0096
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0078 0.0196
Echinococcus granulosus segment polarity protein dishevelled 0.0017 0.0011 0.0011
Onchocerca volvulus 0.0016 0.0006 0.0046
Echinococcus granulosus histone acetyltransferase KAT2B 0.0085 0.0329 0.0329
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0163 0.0163
Echinococcus granulosus cytochrome b5 reductase 4 0.0098 0.039 0.039
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0015
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0102
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0134 0.0559 0.2712
Loa Loa (eye worm) hypothetical protein 0.0136 0.0565 0.1079
Brugia malayi cell junction protein LIN-7 0.0017 0.0011 0.002
Entamoeba histolytica pyruvate kinase, putative 0.0094 0.0369 0.2495
Loa Loa (eye worm) PX domain-containing protein 0.0017 0.0011 0.002
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0015
Entamoeba histolytica Ran family GTPase 0.0044 0.0135 0.0915
Brugia malayi jmjC domain containing protein 0.0049 0.016 0.0306
Echinococcus granulosus cell polarity protein 0.0017 0.0011 0.0011
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0135 0.034
Brugia malayi nuclear hormone receptor 0.0024 0.004 0.0076
Schistosoma mansoni tight junction protein 0.0017 0.0011 0.0011
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0331 0.1478 0.3716
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0615 0.2813 0.537
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0864 0.3978 0.3978
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0163 0.0312
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0071 0.0263 0.0503
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0049 0.016 0.0306
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0163 0.0163
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.039 0.1891
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.007 0.007
Brugia malayi MH1 domain containing protein 0.0077 0.0291 0.0556
Echinococcus multilocularis Partitioning defective 3 protein B 0.0017 0.0011 0.0011
Brugia malayi MH2 domain containing protein 0.0077 0.0291 0.0556
Echinococcus granulosus lamin dm0 0.0031 0.0076 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0382 0.096
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.0263 0.1277
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0096 0.0651
Loa Loa (eye worm) G protein alpha subunit 3 0.0016 0.0005 0.0009
Brugia malayi glutaminase DH11.1 0.0268 0.1186 0.2264
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0015
Mycobacterium ulcerans electron transfer protein FdxB 0.0098 0.039 0.0933
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.022 0.1066
Echinococcus multilocularis disks large 3 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0071 0.0263 0.0503
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0098 0.039 0.1891
Echinococcus granulosus X box binding protein 1 0.0279 0.1238 0.1238
Brugia malayi Peripheral plasma membrane protein CASK 0.0017 0.0011 0.002
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0098 0.039 0.1891
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0076
Brugia malayi gamma-syntrophin-like protein SYN2 0.0017 0.0011 0.002
Loa Loa (eye worm) guanylate kinase 0.0017 0.0011 0.002
Echinococcus multilocularis X box binding protein 1 0.0279 0.1238 0.1238
Brugia malayi flavodoxin family protein 0.0864 0.3978 0.7595
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0382 0.096
Brugia malayi PDZ domain containing protein 0.0018 0.0014 0.0027
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.004 0.0076
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0076 0.0145
Onchocerca volvulus 0.0017 0.0011 0.0081
Echinococcus granulosus pyruvate kinase 0.0134 0.0559 0.0559
Echinococcus granulosus partitioning defective 3 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Echinococcus multilocularis cpg binding protein 0.0031 0.0075 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0163 0.0312
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.0302 0.076
Brugia malayi Guanylate kinase family protein 0.0017 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Mycobacterium ulcerans oxidoreductase 0.0098 0.039 0.0933
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0221 0.0555
Onchocerca volvulus Arc homolog 0.0017 0.0011 0.0081
Trypanosoma cruzi p450 reductase, putative 0.0098 0.039 0.098
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0096 0.0242
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0126 0.0316
Schistosoma mansoni Smad4 0.0035 0.0091 0.0091
Trichomonas vaginalis pyruvate kinase, putative 0.0134 0.0559 0.1406
Brugia malayi hypothetical protein 0.0083 0.0318 0.0606
Echinococcus multilocularis pyruvate kinase 0.0134 0.0559 0.0559
Brugia malayi Pyruvate kinase, M2 isozyme 0.0134 0.0559 0.1068
Echinococcus granulosus JmjC domain containing protein 4 0.0049 0.016 0.016
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0012
Trypanosoma brucei unspecified product 0.0019 0.0021 0.0052
Brugia malayi Probable ClpP-like protease 0.0094 0.0372 0.0711
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0006 0.0015
Schistosoma mansoni lipoxygenase 0.0084 0.0324 0.0324
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0163 0.0163
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0021 0.0052
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0084 0.0159
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0163 0.0312
Echinococcus granulosus intermediate filament protein 0.0031 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.1047 0.4833 0.4833
Leishmania major NADH-dependent fumarate reductase, putative 0.0098 0.039 0.098
Echinococcus multilocularis GPCR, family 2 0.0195 0.0842 0.0842
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.0053 0.0102
Brugia malayi exodeoxyribonuclease III family protein 0.0074 0.0278 0.0531
Schistosoma mansoni hypothetical protein 0.0421 0.19 0.19
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0184 0.0794 0.0794
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0005 0.0005
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0016 0.0005 0.0009
Schistosoma mansoni phd/f-box containing protein 0.0049 0.016 0.016
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0156 0.0392
Schistosoma mansoni zinc finger protein 0.0024 0.004 0.004
Onchocerca volvulus 0.0233 0.1022 0.7731
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0382 0.096
Schistosoma mansoni hypothetical protein 0.1047 0.4833 0.4833
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0372 0.0372
Schistosoma mansoni protein phosphatase 2C 0.0049 0.016 0.016
Leishmania major DNA polymerase eta, putative 0.0045 0.014 0.0353
Trichomonas vaginalis ap endonuclease, putative 0.0074 0.0278 0.0699
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0085 0.0329 0.0828
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.068 0.068
Onchocerca volvulus 0.0016 0.0005 0.0037
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.008 0.0201
Trypanosoma brucei glucosidase, putative 0.0036 0.0096 0.0242
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0024 0.0024
Brugia malayi PDZ domain 0.0017 0.0011 0.002
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0016 0.0005 0.0009
Echinococcus multilocularis neuropeptide receptor A26 0.0569 0.2596 0.2596
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0074 0.0278 0.0699
Onchocerca volvulus 0.0071 0.0263 0.1993
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0271 0.0271
Brugia malayi mothers against decapentaplegic homolog 3 0.0035 0.0091 0.0174
Trypanosoma cruzi nitrate reductase, putative 0.0098 0.039 0.098
Brugia malayi Nuclear hormone receptor E75 0.0024 0.004 0.0076
Schistosoma mansoni cell polarity protein 0.0017 0.0011 0.0011
Schistosoma mansoni cell polarity protein 0.0017 0.0011 0.0011
Schistosoma mansoni jumonji domain containing protein 0.0049 0.016 0.016
Echinococcus multilocularis Smad4 0.0077 0.0291 0.0291
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0098 0.039 0.098
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0098 0.039 0.2012
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0102
Schistosoma mansoni hypothetical protein 0.0636 0.2911 0.2911
Mycobacterium leprae Probable pyruvate kinase PykA 0.0134 0.0559 1
Schistosoma mansoni rotamase 0.0033 0.0084 0.0084
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.016 0.0306
Brugia malayi acetyltransferase, GNAT family protein 0.029 0.1289 0.2461
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.004 0.0076
Schistosoma mansoni hypothetical protein 0.0195 0.0842 0.0842
Schistosoma mansoni tar DNA-binding protein 0.0064 0.023 0.023
Echinococcus granulosus MAGUK p55 subfamily 0.0017 0.0011 0.0011
Echinococcus granulosus expressed protein 0.0016 0.0005 0.0005
Plasmodium vivax importin-beta 2, putative 0.006 0.0209 0.0525
Trypanosoma brucei NADH-dependent fumarate reductase 0.0098 0.039 0.098
Schistosoma mansoni thyroid hormone receptor 0.005 0.0163 0.0163
Schistosoma mansoni lin-7-like proteins 0.0017 0.0011 0.0011
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0126 0.0316
Schistosoma mansoni cell polarity protein 0.0017 0.0011 0.0011
Schistosoma mansoni MAGUK homolog 0.0017 0.0011 0.0011
Loa Loa (eye worm) RasGEF domain-containing protein 0.0017 0.0011 0.002
Loa Loa (eye worm) MH2 domain-containing protein 0.0077 0.0291 0.0556
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0209 0.0525
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0263 0.0614
Echinococcus granulosus protein lin 7 B 0.0017 0.0011 0.0011
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0049 0.016 0.0403
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Echinococcus multilocularis Na(+):H(+) exchange regulatory cofactor NHE RF2 0.0017 0.0011 0.0011
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0021 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0009
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0016 0.0005 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0163 0.0312
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0098 0.039 0.1568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0015
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Brugia malayi MH1 domain containing protein 0.0043 0.013 0.0248
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0024 0.0024
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0017 0.0011 0.0011
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.068 0.1298
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0135 0.0135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0221 0.0555
Schistosoma mansoni inositol monophosphatase 0.008 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Onchocerca volvulus 0.0024 0.004 0.0302
Schistosoma mansoni importin beta-1 0.006 0.0209 0.0209
Giardia lamblia Kinase, PLK 0.0097 0.0382 0.1086
Echinococcus multilocularis microtubule associated protein 2 0.2149 1 1
Schistosoma mansoni pdz domain containing protein 0.0017 0.0011 0.0011
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0049 0.016 0.0403
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0006 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0263 0.0662
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0126 0.0316
Schistosoma mansoni pyruvate kinase 0.0134 0.0559 0.0559
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0163 0.0163
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0098 0.039 0.098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0221 0.0555
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Schistosoma mansoni inositol monophosphatase 0.008 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0076
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0017 0.0011 0.002
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.004 0.004
Echinococcus multilocularis partitioning defective protein 6 0.0017 0.0011 0.0011
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0864 0.3978 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0126 0.0357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0163 0.0312
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0135 0.0135
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0195 0.0842 0.0842
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0011
Schistosoma mansoni nuclear receptor 0.0024 0.004 0.004
Mycobacterium ulcerans glutaminase 0.0268 0.1186 0.2944
Schistosoma mansoni lamin 0.0031 0.0076 0.0076
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.004 0.0076
Schistosoma mansoni maguk P55 subfamily member 26 0.0017 0.0011 0.0011
Brugia malayi Abnormal embryonic partitioning of cytoplasm protein 3 0.0017 0.0011 0.002
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0006 0.0015
Plasmodium falciparum histone acetyltransferase GCN5 0.0078 0.0296 0.0744
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0006 0.0006
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.008 0.054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0221 0.0555
Loa Loa (eye worm) beta-lactamase 0.0071 0.0263 0.0503
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0263 0.0263
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0163 0.0163
Echinococcus multilocularis pyruvate kinase 0.0134 0.0559 0.0559
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0221 0.0555
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0135 0.034
Schistosoma mansoni lamin 0.0031 0.0076 0.0076
Schistosoma mansoni discs large 0.0017 0.0011 0.0011
Trypanosoma brucei polo-like protein kinase 0.0097 0.0382 0.096
Echinococcus multilocularis glutamate receptor interacting protein 1 0.0017 0.0011 0.0011
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0006 0.0015
Brugia malayi PDZ domain containing protein 0.0017 0.0011 0.002
Brugia malayi Muscleblind-like protein 0.015 0.0634 0.121
Echinococcus granulosus segment polarity protein dishevelled 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0098 0.039 0.039
Brugia malayi MH2 domain containing protein 0.0077 0.0291 0.0556
Echinococcus granulosus muscleblind protein 0.015 0.0634 0.0634
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0263 0.0503
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0015
Echinococcus granulosus Smad4 0.0077 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.005 0.0163 0.0312
Echinococcus granulosus Rho GTPase activating protein 21 0.0017 0.0011 0.0011
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0016 0.0005 0.0012
Schistosoma mansoni PDZ domain protein 0.0017 0.0011 0.0011
Brugia malayi FAD binding domain containing protein 0.0534 0.2429 0.4639
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0011
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0017 0.0011 0.0011
Onchocerca volvulus Big bang homolog 0.0017 0.0011 0.0081
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0864 0.3978 0.3978
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0006 0.0012
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.014
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0005 0.0009
Leishmania major importin beta-1 subunit, putative 0.0048 0.0156 0.0392
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0017 0.0011 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.1133 0.5238 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.014 0.0268
Schistosoma mansoni smad 0.0077 0.0291 0.0291
Schistosoma mansoni cpg binding protein 0.0031 0.0075 0.0075
Onchocerca volvulus 0.0017 0.0011 0.0081
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.004 0.004
Schistosoma mansoni ap endonuclease 0.0074 0.0278 0.0278
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0005 0.0005
Brugia malayi intermediate filament protein 0.0031 0.0076 0.0145
Loa Loa (eye worm) pyruvate kinase-PB 0.0094 0.0369 0.0704
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0163 0.0312
Plasmodium vivax vivapain-2 0.0016 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0049 0.016 0.0306
Onchocerca volvulus 0.0016 0.0006 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Echinococcus granulosus rho guanine nucleotide exchange factor 12 0.0017 0.0011 0.0011
Leishmania major DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0064 0.023 0.023
Echinococcus multilocularis cytochrome b5 reductase 4 0.0098 0.039 0.039
Schistosoma mansoni thyroid hormone receptor 0.005 0.0163 0.0163
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.004 0.0076
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0382 0.289
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0135 0.034
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0126 0.0316
Echinococcus granulosus disks large 1 0.0017 0.0011 0.0011
Brugia malayi nuclear receptor RXR 0.0026 0.0053 0.0102
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0372 0.0936
Brugia malayi hypothetical protein 0.0073 0.0271 0.0518
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0021 0.01
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0096 0.0242
Schistosoma mansoni nuclear receptor 0.0024 0.004 0.004
Schistosoma mansoni pdz domain containing protein 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Schistosoma mansoni polycystin 1-related 0.002 0.0024 0.0024
Plasmodium falciparum ataxin-2 like protein, putative 0.0128 0.053 0.1333
Loa Loa (eye worm) latrophilin receptor protein 2 0.0195 0.0842 0.1607
Plasmodium vivax vivapain-2 0.0016 0.0006 0.0015
Brugia malayi syntenin 0.0017 0.0011 0.002
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0021 0.0052
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0135 0.0258
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0024 0.0024
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0864 0.3978 0.3978
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0074 0.0278 0.079
Echinococcus granulosus syndecan binding protein syntenin 0.0017 0.0011 0.0011
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0195 0.0842 0.0842
Loa Loa (eye worm) hypothetical protein 0.0128 0.053 0.1013
Giardia lamblia DINP protein human, muc B family 0.0019 0.0021 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0382 0.096
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0455 0.2062 1
Brugia malayi hypothetical protein 0.002 0.0024 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0096 0.0242
Echinococcus multilocularis protein piccolo 0.0017 0.0011 0.0011
Loa Loa (eye worm) ctsf protein 0.0016 0.0006 0.0012
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0017 0.0011 0.0011
Trichomonas vaginalis esterase, putative 0.0071 0.0263 0.0662
Onchocerca volvulus 0.0017 0.0011 0.0081
Entamoeba histolytica G protein alpha subunit, putative 0.0016 0.0005 0.0033
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0005 0.0005
Loa Loa (eye worm) MH1 domain-containing protein 0.0077 0.0291 0.0556
Echinococcus granulosus multiple pdz domain protein 0.0017 0.0011 0.0011
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.008 0.0302 0.0712
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0074 0.0278 0.0699
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0017 0.0011 0.0011
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.022 0.022
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.0889 0.1698
Onchocerca volvulus Pyruvate kinase homolog 0.0134 0.0559 0.4232
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0096 0.0242
Schistosoma mansoni lim domain 0.0017 0.0011 0.0011
Trypanosoma cruzi p450 reductase, putative 0.0864 0.3978 1
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0263 0.1278
Mycobacterium ulcerans oxygenase 0.0098 0.039 0.0933
Schistosoma mansoni ran 0.0044 0.0135 0.0135
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0766 0.3518 0.8843
Loa Loa (eye worm) hypothetical protein 0.0134 0.0559 0.1068
Trichomonas vaginalis set domain proteins, putative 0.0233 0.1022 0.2568
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0076
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0096 0.0242
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0041 0.012 0.0229
Loa Loa (eye worm) transcription factor SMAD2 0.1133 0.5238 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0163 0.0312
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0163 0.0312
Loa Loa (eye worm) PDZ domain-containing protein 0.0017 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0015 0 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0015
Mycobacterium leprae Probable lipase LipE 0.0071 0.0263 0.38
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0126 0.0126
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0121 0.0494 0.0494
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0005 0.0005
Echinococcus multilocularis pdz domain containing protein 0.0017 0.0011 0.0011
Brugia malayi hypothetical protein 0.0016 0.0005 0.0009
Echinococcus multilocularis PRKCA binding protein 0.0017 0.0011 0.0011
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0024 0.0024
Echinococcus multilocularis lamin dm0 0.0031 0.0076 0.0076
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0071 0.0263 0.0503
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0006 0.0015
Trypanosoma cruzi pyruvate kinase 2, putative 0.0134 0.0559 0.1406
Brugia malayi pyruvate kinase, muscle isozyme 0.0028 0.0062 0.0119
Brugia malayi flavodoxin family protein 0.0331 0.1478 0.2822
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.016 0.0306
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0021 0.0021
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0372 0.0888
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0076
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0372 0.1494
Schistosoma mansoni DNA polymerase eta 0.0045 0.014 0.014
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0126 0.0316
Plasmodium vivax hypothetical protein, conserved 0.0331 0.1478 0.3716
Schistosoma mansoni diflavin oxidoreductase 0.0429 0.1938 0.1938
Loa Loa (eye worm) pyruvate kinase 0.0134 0.0559 0.1068
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0076
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0374 0.1681 0.3209
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0074 0.0278 0.065
Loa Loa (eye worm) syntrophin-1 0.0017 0.0011 0.002
Onchocerca volvulus 0.0071 0.0263 0.1993
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0096 0.0242
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.004 0.0302
Echinococcus granulosus mothers against decapentaplegic 6 0.0035 0.0091 0.0091
Onchocerca volvulus 0.0031 0.0076 0.0575
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0126 0.0126
Leishmania major NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Echinococcus granulosus Na:H exchange regulatory cofactor NHE RF2 0.0017 0.0011 0.0011
Echinococcus multilocularis multiple pdz domain protein 0.0017 0.0011 0.0011
Trypanosoma brucei NADH-dependent fumarate reductase 0.0098 0.039 0.098
Entamoeba histolytica type A flavoprotein, putative 0.0331 0.1478 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0864 0.3978 1
Onchocerca volvulus 0.0016 0.0006 0.0046
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0102
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Echinococcus multilocularis neuropeptide s receptor 0.0569 0.2596 0.2596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0015
Leishmania major cathepsin L-like protease 0.0062 0.0221 0.0555
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.029 0.1289 0.1289
Loa Loa (eye worm) hypothetical protein 0.0071 0.0263 0.0503
Echinococcus granulosus cytochrome b5 reductase 4 0.0098 0.039 0.039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0076 0.0145
Leishmania major p450 reductase, putative 0.0864 0.3978 1
Echinococcus granulosus GPCR family 2 0.0195 0.0842 0.0842
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0074 0.0278 0.0699
Schistosoma mansoni cpg binding protein 0.0029 0.0067 0.0067
Echinococcus multilocularis importin subunit beta 1 0.006 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0076
Echinococcus granulosus glutamate receptor interacting protein 1 0.0017 0.0011 0.0011
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0221 0.0555
Plasmodium falciparum nitric oxide synthase, putative 0.0864 0.3978 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0098 0.039 0.098
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0077 0.0291 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0163 0.0312
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.004 0.004
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.004 0.004
Brugia malayi hypothetical protein 0.002 0.0024 0.0046
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0372 0.192
Brugia malayi hypothetical protein 0.0297 0.1321 0.2523
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0005 0.0005
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0058 0.0199 0.0199
Echinococcus multilocularis expressed protein 0.0033 0.0084 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0163 0.0312
Toxoplasma gondii flavodoxin domain-containing protein 0.0429 0.1938 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.068 0.068
Loa Loa (eye worm) gopc protein 0.0017 0.0011 0.002
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0049 0.016 0.016
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.008 0.0201
Echinococcus multilocularis pyruvate kinase 0.0069 0.0253 0.0253
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0021 0.0139
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0015
Loa Loa (eye worm) FAD binding domain-containing protein 0.0534 0.2429 0.4639
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0085 0.0329 0.0828
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0163 0.0312
Echinococcus multilocularis segment polarity protein dishevelled 0.0017 0.0011 0.0011
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0098 0.039 0.098
Brugia malayi Partitioning defective-6 homolog alpha 0.0017 0.0011 0.002
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0331 0.1478 0.3716
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0135 0.0698
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0016 0.0005 0.0012
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0082 0.0206
Schistosoma mansoni nuclear hormone receptor 0.005 0.0163 0.0163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0374 0.1681 0.1681
Brugia malayi Protein-tyrosine phosphatase 1 0.0017 0.0011 0.002
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0864 0.3978 1
Plasmodium vivax SET domain protein, putative 0.003 0.007 0.0176
Leishmania major oxidoreductase-like protein 0.0098 0.039 0.098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0015
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0184 0.0794 0.0794
Trichomonas vaginalis rotamase, putative 0.0033 0.0084 0.021
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.008 0.0412
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0016 0.0005 0.0009
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0163 0.0163
Echinococcus granulosus snurportin 1 0.0636 0.2911 0.2911
Schistosoma mansoni sap-97 0.0017 0.0011 0.0011
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0096 0.0651
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0015
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0015
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0016 0.0005 0.0005
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0126 0.0126
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0011
Brugia malayi PDZ domain containing protein 0.0017 0.0011 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0374 0.1681 0.1681
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0382 0.2584
Brugia malayi Latrophilin receptor protein 2 0.0195 0.0842 0.1607
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0163 0.0312
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0263 0.0662
Trypanosoma cruzi oxidoreductase-protein, putative 0.0098 0.039 0.098
Schistosoma mansoni Smad4 0.0077 0.0291 0.0291
Echinococcus multilocularis tumor protein p63 0.0342 0.1533 0.1533
Onchocerca volvulus 0.0016 0.0005 0.0037
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.022 0.1066
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0163 0.0312
Echinococcus multilocularis partitioning defective 3 0.0017 0.0011 0.0011
Loa Loa (eye worm) glutaminase 2 0.0268 0.1186 0.2264
Echinococcus granulosus pdz domain containing protein 0.0017 0.0011 0.0011
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0636 0.2911 0.5557
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.1888 0.1888
Echinococcus multilocularis pyruvate kinase 0.0069 0.0253 0.0253
Chlamydia trachomatis sulfite reductase 0.0534 0.2429 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0163 0.0312
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0126 0.0126
Plasmodium falciparum importin beta, putative 0.006 0.0209 0.0525
Brugia malayi nuclear receptor NHR-67 0.0024 0.004 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0006 0.0012
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0096 0.0242
Brugia malayi hypothetical protein 0.0017 0.0011 0.002
Brugia malayi Pyruvate kinase, muscle isozyme 0.0134 0.0559 0.1068
Brugia malayi conserved hypotetical protein 0.0024 0.004 0.0076
Schistosoma mansoni smad1 5 8 and 0.0077 0.0291 0.0291
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0011
Giardia lamblia Pyruvate kinase 0.0069 0.0253 0.0719
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0163 0.1237
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0005 0.0012
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0098 0.039 0.039
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0016 0.0005 0.0009
Echinococcus multilocularis pdz domain containing protein 0.0017 0.0011 0.0011
Leishmania major pyruvate kinase 0.0134 0.0559 0.1406
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.007 0.007
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0078 0.0401
Echinococcus multilocularis partitioning defective 3 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0195 0.0842 0.1607
Loa Loa (eye worm) hypothetical protein 0.005 0.0163 0.0312
Onchocerca volvulus 0.0098 0.039 0.2951
Schistosoma mansoni ATP-dependent RNA Helicase 0.0017 0.0011 0.0011
Mycobacterium tuberculosis Conserved protein 0.0071 0.0263 0.1278
Brugia malayi hypothetical protein 0.0024 0.004 0.0076
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0017 0.0011 0.0011
Echinococcus granulosus dna polymerase kappa 0.0019 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0102
Echinococcus multilocularis JmjC domain containing protein 4 0.0049 0.016 0.016
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0006 0.0015
Plasmodium vivax JmjC domain containing protein 0.0049 0.016 0.0403
Onchocerca volvulus 0.0017 0.0011 0.0081
Echinococcus multilocularis beta 1 syntrophin 0.0017 0.0011 0.0011
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0163 0.1237
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0229 0.1179
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0016 0.0005 0.0012
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0021 0.0021
Loa Loa (eye worm) cell junction protein LIN-7 0.0017 0.0011 0.002
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0074 0.0278 0.188
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0163 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0163 0.0312
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0263 0.0662
Loa Loa (eye worm) PAR-6 protein 0.0017 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.002
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.068 0.068
Onchocerca volvulus Pyruvate kinase homolog 0.0134 0.0559 0.4232
Brugia malayi TAR-binding protein 0.0064 0.023 0.044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0015

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.3109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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