Detailed information for compound 165369

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 541.621 | Formula: C29H27N5O4S
  • H donors: 4 H acceptors: 4 LogP: 3.25 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C([C@H](NC(=O)c1cccc(c1)C(=N)N)Cc1ccccc1)Nc1ccc(cc1)c1ccccc1S(=O)(=O)N
  • InChi: 1S/C29H27N5O4S/c30-27(31)21-9-6-10-22(18-21)28(35)34-25(17-19-7-2-1-3-8-19)29(36)33-23-15-13-20(14-16-23)24-11-4-5-12-26(24)39(32,37)38/h1-16,18,25H,17H2,(H3,30,31)(H,33,36)(H,34,35)(H2,32,37,38)/t25-/m1/s1
  • InChiKey: CHQNQZTUBMLBST-RUZDIDTESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References
Homo sapiens protease, serine, 1 (trypsin 1) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Trypsin family protein protease, serine, 1 (trypsin 1) 247 aa 287 aa 21.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0059 0.026 0.0252
Echinococcus multilocularis ecdysone induced protein 78C 0.04 0.2544 0.2539
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.04 0.2544 0.2539
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0048 0.0184 0.0333
Loa Loa (eye worm) guanylate kinase 0.0039 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.012 0.0667 0.0667
Echinococcus multilocularis aldo keto reductase 0.0149 0.0866 0.0859
Trypanosoma brucei aldo-keto reductase, putative 0.0149 0.0866 0.0808
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0048 0.0184 0.0333
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.048 0.3081 0.3076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0031 0.0073 0.0065
Leishmania major nitrate reductase, putative 0.0172 0.1017 0.101
Brugia malayi gamma-syntrophin-like protein SYN2 0.0039 0.0128 0.012
Schistosoma mansoni cpg binding protein 0.0026 0.004 0.0032
Loa Loa (eye worm) RGC/RGC protein kinase 0.0115 0.0638 0.0638
Brugia malayi microtubule-associated serine/threonine protein kinase 2 (MAST2) 0.0039 0.0128 0.012
Echinococcus granulosus pdz domain containing protein 0.0039 0.0128 0.012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.04 0.2544 0.2539
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0172 0.1017 0.2066
Echinococcus multilocularis glutamate receptor 2 0.0924 0.6052 0.6049
Leishmania major hypothetical protein, conserved 0.003 0.0063 0.0055
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0039 0.0128 0.012
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0024 0.0024 0.0016
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0663 0.4306 0.4302
Echinococcus multilocularis disks large 1 0.0039 0.0128 0.012
Brugia malayi 9ORF binding protein 1 0.0039 0.0128 0.012
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0058 0.0255 0.0248
Schistosoma mansoni hypothetical protein 0.0146 0.0842 0.0834
Brugia malayi C2 domain containing protein 0.0039 0.0128 0.012
Leishmania major NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.101
Brugia malayi Glutamate receptor 1 precursor 0.1033 0.6787 0.6784
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Schistosoma mansoni diflavin oxidoreductase 0.0751 0.4894 0.489
Brugia malayi Nuclear hormone receptor family member nhr-19 0.04 0.2544 0.2539
Brugia malayi nuclear receptor NHR-88 0.0185 0.1107 0.1101
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0024 0.0024 0.0016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.0667 0.066
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0579 0.3742 0.3737
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0024 0.0024 0.0016
Brugia malayi Receptor family ligand binding region containing protein 0.0115 0.0638 0.0631
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0039 0.0128 0.012
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0039 0.0128 0.012
Onchocerca volvulus 0.004 0.013 0.0327
Trichomonas vaginalis aldo-keto reductase, putative 0.0149 0.0866 0.0722
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0579 0.3742 0.3702
Loa Loa (eye worm) hypothetical protein 0.0185 0.1107 0.1107
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.1149 0.756 0.7558
Brugia malayi Peripheral plasma membrane protein CASK 0.0039 0.0128 0.012
Leishmania major cytochrome-b5 reductase, putative 0.0172 0.1017 0.101
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0149 0.0866 0.0722
Echinococcus granulosus aldo keto reductase 0.0149 0.0866 0.0859
Echinococcus granulosus syndecan binding protein syntenin 0.0039 0.0128 0.012
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0024 0.0024 0.0016
Brugia malayi hypothetical protein 0.0215 0.1302 0.1295
Leishmania major cytochrome P450 reductase, putative 0.1341 0.8848 0.8847
Brugia malayi diaphorase 0.0172 0.1017 0.101
Brugia malayi orphan nuclear receptor NR2E1 0.0185 0.1107 0.1101
Loa Loa (eye worm) cytochrome P450 family protein 0.0106 0.0578 0.0578
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0149 0.0866 0.0859
Echinococcus multilocularis glutamate receptor interacting protein 1 0.0039 0.0128 0.012
Echinococcus granulosus cell polarity protein 0.0039 0.0128 0.012
Trypanosoma cruzi aldo/keto reductase, putative 0.0149 0.0866 0.0859
Plasmodium vivax hypothetical protein, conserved 0.0579 0.3742 0.3737
Echinococcus multilocularis FTZ F1 alpha 0.04 0.2544 0.2539
Leishmania major NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.101
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0039 0.0128 0.012
Onchocerca volvulus 0.0156 0.0908 0.2399
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0106 0.0578 0.043
Echinococcus multilocularis tyrosine kinase 0.0115 0.0638 0.0631
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0185 0.1107 0.1101
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0048 0.0184 0.0333
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.0021 0.0021
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0579 0.3742 0.3643
Echinococcus granulosus neuropeptide s receptor 0.0403 0.2567 0.2561
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0048 0.0184 0.0333
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0172 0.1017 0.101
Loa Loa (eye worm) hypothetical protein 0.0185 0.1107 0.1107
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0663 0.4306 0.4302
Onchocerca volvulus 0.0025 0.0031 0.0061
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0048 0.0187 0.0032
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0156 0.0908 0.2276
Brugia malayi Nuclear hormone receptor family member nhr-40 0.04 0.2544 0.2539
Echinococcus multilocularis glutamate receptor 4 0.0425 0.2714 0.2708
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0149 0.0866 0.0859
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.1513 1 1
Schistosoma mansoni nuclear hormone receptor 0.0185 0.1107 0.1101
Schistosoma mansoni protein kinase C alpha binding protein 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0185 0.1107 0.1107
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.0961
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0048 0.0184 0.0029
Brugia malayi Pre-SET motif family protein 0.0026 0.0041 0.0033
Onchocerca volvulus 0.0172 0.1017 0.2691
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0304 0.1901 0.1895
Brugia malayi hypothetical protein 0.0215 0.1302 0.1295
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0071 0.0342 0.0335
Echinococcus multilocularis 0.0039 0.0128 0.012
Schistosoma mansoni cytochrome P450 reductase 0.1513 1 1
Loa Loa (eye worm) oxidoreductase 0.0149 0.0866 0.0866
Echinococcus granulosus partitioning defective 3 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0041 0.0033
Loa Loa (eye worm) hypothetical protein 0.0215 0.1302 0.1302
Toxoplasma gondii aldo-keto reductase 0.0043 0.0155 0.0301
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0039 0.0128 0.012
Trichomonas vaginalis sulfite reductase, putative 0.1513 1 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0048 0.0184 0.0029
Leishmania major aldo-keto reductase-like protein 0.0149 0.0866 0.0859
Loa Loa (eye worm) hypothetical protein 0.0076 0.0377 0.0377
Echinococcus multilocularis ligand of numb protein x 2 0.0039 0.0128 0.012
Onchocerca volvulus 0.04 0.2544 0.6762
Schistosoma mansoni cell polarity protein 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0185 0.1107 0.1107
Schistosoma mansoni ATP-dependent RNA Helicase 0.0039 0.0128 0.012
Echinococcus multilocularis aldo keto reductase 0.0149 0.0866 0.0859
Onchocerca volvulus 0.0115 0.0638 0.168
Onchocerca volvulus 0.0066 0.0308 0.0801
Brugia malayi Guanylate kinase family protein 0.0039 0.0128 0.012
Schistosoma mansoni multiple pdz domain protein 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0008
Schistosoma mansoni nuclear hormone receptor 0.04 0.2544 0.2539
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0039 0.0128 0.012
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0048 0.0184 0.0029
Plasmodium falciparum aldehyde reductase, putative 0.0043 0.0155 0.0147
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0039 0.0128 0.012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.04 0.2544 0.2539
Loa Loa (eye worm) cell junction protein LIN-7 0.0039 0.0128 0.0128
Schistosoma mansoni cytochrome P450 0.0048 0.0184 0.0176
Loa Loa (eye worm) RasGEF domain-containing protein 0.0039 0.0128 0.0128
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0149 0.0866 0.0859
Loa Loa (eye worm) transcription factor SMAD2 0.0103 0.0553 0.0553
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0048 0.0184 0.0333
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1162 0.7645 0.7643
Schistosoma mansoni sh3 and multiple ankyrin repeat domains protein 12 (shank12) 0.0039 0.0128 0.012
Schistosoma mansoni discs lost-related 0.0039 0.0128 0.012
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.1513 1 1
Echinococcus granulosus glutamate receptor subunit protein glur 0.065 0.4221 0.4216
Loa Loa (eye worm) hypothetical protein 0.0115 0.0638 0.0638
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0108 0.0586 0.5002
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.101
Schistosoma mansoni hypothetical protein 0.0039 0.0128 0.012
Brugia malayi Cytochrome P450 family protein 0.0048 0.0184 0.0176
Loa Loa (eye worm) hypothetical protein 0.0062 0.0281 0.0281
Echinococcus granulosus ecdysone induced protein 78C 0.04 0.2544 0.2539
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0048 0.0184 0.0029
Mycobacterium ulcerans electron transfer protein FdxB 0.0172 0.1017 0.0876
Trichomonas vaginalis aldo-keto reductase, putative 0.0149 0.0866 0.0722
Echinococcus multilocularis pdz domain containing protein 0.0039 0.0128 0.012
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0039 0.0128 0.012
Leishmania major oxidoreductase-like protein 0.0172 0.1017 0.101
Schistosoma mansoni cell polarity protein 0.0039 0.0128 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.04 0.2544 0.2544
Echinococcus multilocularis microtubule associated serine:threonine protein 0.004 0.013 0.0123
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0149 0.0866 0.0722
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.0041 0.0033
Echinococcus granulosus receptor type guanylyl cyclase 0.0115 0.0638 0.0631
Onchocerca volvulus 0.0039 0.0128 0.032
Echinococcus multilocularis neurabin 1 0.0039 0.0128 0.012
Schistosoma mansoni coup transcription factor 0.04 0.2544 0.2539
Brugia malayi nuclear receptor RXR 0.0185 0.1107 0.1101
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0048 0.0184 0.0333
Echinococcus multilocularis 0.0048 0.0184 0.0176
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0149 0.0866 0.0859
Toxoplasma gondii cytochrome p450 superfamily protein 0.0048 0.0184 0.036
Plasmodium vivax flavodoxin domain containing protein 0.1341 0.8848 0.8847
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Schistosoma mansoni potassium channel beta 0.0043 0.0155 0.0147
Schistosoma mansoni retinoic acid receptor RXR 0.0484 0.3108 0.3103
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.003 0.0063 0.0055
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0024 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.0055 0.0236 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-49 0.04 0.2544 0.2539
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.003 0.0063 0.0055
Echinococcus granulosus metabotropic glutamate receptor 2 0.0115 0.0638 0.0631
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0172 0.1017 0.101
Schistosoma mansoni dishevelled 0.0039 0.0128 0.012
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0185 0.1107 0.1101
Echinococcus multilocularis pdz domain containing protein 0.0039 0.0128 0.012
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0048 0.0184 0.0029
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1162 0.7645 0.7643
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0225 0.1373 0.1366
Trypanosoma cruzi p450 reductase, putative 0.1513 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0184 0.0184
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0048 0.0184 0.0029
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0039 0.0128 0.012
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0024 0.0024 0.0016
Echinococcus granulosus thyroid hormone receptor alpha 0.0185 0.1107 0.1101
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Schistosoma mansoni MAGUK homolog 0.0039 0.0128 0.012
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0048 0.0184 0.0333
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0024 0.0024 0.0016
Schistosoma mansoni multiple pdz domain protein 0.0039 0.0128 0.012
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0043 0.0155 0.0155
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0579 0.3742 0.3737
Brugia malayi cell junction protein LIN-7 0.0039 0.0128 0.012
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0053 0.0223 0.0215
Echinococcus multilocularis pdz domain containing protein 0.0039 0.0128 0.012
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0048 0.0184 0.0029
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0048 0.0184 0.0176
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Schistosoma mansoni ATP-binding cassette transporter 0.0608 0.3938 0.3934
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0172 0.1017 0.1017
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0187 0.0179
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0172 0.1017 0.0961
Brugia malayi Guanylate kinase family protein 0.0039 0.0128 0.012
Echinococcus multilocularis beta 1 syntrophin 0.0039 0.0128 0.012
Brugia malayi MH2 domain containing protein 0.0103 0.0553 0.0546
Echinococcus granulosus protein lin 7 B 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Onchocerca volvulus 0.0149 0.0866 0.2287
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Plasmodium falciparum ferredoxin--NADP reductase 0.0172 0.1017 0.101
Brugia malayi Patj homolog 0.0039 0.0128 0.012
Brugia malayi PDZ domain 0.0039 0.0128 0.012
Brugia malayi Partitioning defective-6 homolog alpha 0.0039 0.0128 0.012
Echinococcus multilocularis protein piccolo 0.0039 0.0128 0.012
Brugia malayi hypothetical protein 0.0039 0.0128 0.012
Schistosoma mansoni cell polarity protein 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0062 0.0281 0.0281
Leishmania major reductase, putative 0.0172 0.1017 0.101
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Mycobacterium tuberculosis Probable oxidoreductase 0.0172 0.1017 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0048 0.0184 0.0333
Echinococcus multilocularis segment polarity protein dishevelled 0.0039 0.0128 0.012
Schistosoma mansoni pol-related 0.0149 0.0866 0.0859
Toxoplasma gondii flavodoxin domain-containing protein 0.0751 0.4894 1
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.0961
Loa Loa (eye worm) hypothetical protein 0.0026 0.0041 0.0041
Echinococcus granulosus Microtubule-associated serine/threonine-protein kinase 0.004 0.013 0.0123
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0021
Brugia malayi nuclear receptor NHR-67 0.0185 0.1107 0.1101
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.04 0.2544 0.2539
Echinococcus granulosus amyloid beta A4 protein 0.0039 0.0128 0.012
Onchocerca volvulus 0.0185 0.1107 0.2932
Brugia malayi calpain family protein 1 0.0055 0.0236 0.0229
Loa Loa (eye worm) glutamate receptor 0.0115 0.0638 0.0638
Brugia malayi nuclear hormone receptor family member nhr-6 0.0185 0.1107 0.1101
Trypanosoma brucei oxidoreductase-protein, putative 0.0172 0.1017 0.0961
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0579 0.3742 0.3737
Loa Loa (eye worm) FAD binding domain-containing protein 0.0934 0.6123 0.6123
Echinococcus granulosus disks large 3 0.0039 0.0128 0.012
Giardia lamblia Nitric oxide synthase, inducible 0.1341 0.8848 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.04 0.2544 0.2544
Schistosoma mansoni thyroid hormone receptor 0.04 0.2544 0.2539
Loa Loa (eye worm) RGC/RGC protein kinase 0.0115 0.0638 0.0638
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0115 0.0638 0.0638
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0048 0.0184 0.0176
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Echinococcus granulosus ligand of numb protein x 2 0.0039 0.0128 0.012
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0024 0.0024 0.0016
Brugia malayi PDZ domain 0.0039 0.0128 0.012
Onchocerca volvulus 0.0039 0.0128 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0018
Echinococcus granulosus metabotropic glutamate receptor 5 0.0115 0.0638 0.0631
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.018 0.1068 0.1068
Mycobacterium ulcerans monooxygenase 0.0172 0.1017 0.0876
Trichomonas vaginalis aldo-keto reductase, putative 0.0149 0.0866 0.0722
Schistosoma mansoni hypothetical protein 0.0039 0.0128 0.012
Loa Loa (eye worm) flavodoxin family protein 0.0579 0.3742 0.3742
Brugia malayi Receptor family ligand binding region containing protein 0.0115 0.0638 0.0631
Entamoeba histolytica protein kinase, putative 0.0077 0.0379 0.0836
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0039 0.0128 0.012
Brugia malayi NADH-dependent xylose reductase 0.0043 0.0155 0.0147
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0024 0.0024 0.0016
Schistosoma mansoni hypothetical protein 0.0039 0.0128 0.012
Leishmania major cytochrome p450-like protein 0.0106 0.0578 0.0571
Brugia malayi Synapse defective protein 1 0.0039 0.0128 0.012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.04 0.2544 0.2539
Echinococcus multilocularis multiple pdz domain protein 0.0039 0.0128 0.012
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.1513 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.04 0.2544 0.2539
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0024 0.0024 0.0016
Echinococcus granulosus pdz domain containing protein 0.0039 0.0128 0.012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0304 0.1901 0.1901
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0149 0.0866 0.0859
Echinococcus multilocularis MAGUK p55 subfamily 0.0039 0.0128 0.012
Schistosoma mansoni glutamate receptor NMDA 0.0608 0.3938 0.3934
Brugia malayi hypothetical protein 0.0039 0.0128 0.012
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0215 0.1302 0.1295
Mycobacterium leprae Conserved hypothetical protein 0.0106 0.0576 0.5922
Loa Loa (eye worm) hypothetical protein 0.0115 0.0638 0.0638
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0041 0.0033
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0077 0.0379 0.0319
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0215 0.1302 0.1302
Loa Loa (eye worm) oxidoreductase 0.0149 0.0866 0.0866
Echinococcus multilocularis NMDA receptor 0.0663 0.4306 0.4302
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0215 0.1302 0.1295
Onchocerca volvulus 0.0043 0.0155 0.0393
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0608 0.3938 0.3934
Brugia malayi nuclear hormone receptor family member odr-7 0.0185 0.1107 0.1101
Chlamydia trachomatis sulfite reductase 0.0934 0.6123 1
Echinococcus multilocularis glutamate receptor 2 0.1149 0.756 0.7558
Loa Loa (eye worm) hypothetical protein 0.1513 1 1
Echinococcus multilocularis nmda type glutamate receptor 0.0225 0.1373 0.1366
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0048 0.0184 0.0333
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0215 0.1302 0.1302
Loa Loa (eye worm) X11 protein 0.0039 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.04 0.2544 0.2544
Schistosoma mansoni hypothetical protein 0.0039 0.0128 0.012
Echinococcus granulosus beta 1 syntrophin 0.0039 0.0128 0.012
Echinococcus multilocularis microtubule associated protein 2 0.0594 0.3841 0.3837
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.04 0.2544 0.2539
Schistosoma mansoni nuclear receptor 0.0185 0.1107 0.1101
Onchocerca volvulus 0.0115 0.0638 0.168
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0149 0.0866 0.0859
Loa Loa (eye worm) apoptosis regulator protein 0.0071 0.0342 0.0342
Echinococcus multilocularis MAGUK p55 subfamily 0.0039 0.0128 0.012
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0663 0.4306 0.4302
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0185 0.1107 0.1101
Schistosoma mansoni pdz domain containing protein 0.0039 0.0128 0.012
Trypanosoma cruzi oxidoreductase-protein, putative 0.0172 0.1017 0.101
Mycobacterium ulcerans oxygenase 0.0172 0.1017 0.0876
Onchocerca volvulus 0.0039 0.0128 0.032
Echinococcus granulosus Nuclear hormone receptor HR96 0.0185 0.1107 0.1101
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0059 0.026 0.0252
Onchocerca volvulus 0.0023 0.0021 0.0034
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0039 0.0128 0.012
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0048 0.0184 0.0029
Echinococcus multilocularis tight junction protein ZO 3 0.0039 0.0128 0.012
Echinococcus multilocularis partitioning defective 3 0.0039 0.0128 0.012
Brugia malayi ecdysteroid receptor 0.0531 0.3422 0.3417
Echinococcus multilocularis amyloid beta A4 protein 0.0039 0.0128 0.012
Mycobacterium leprae Conserved hypothetical protein 0.0048 0.0184 0.0404
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0048 0.0184 0.0333
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0043 0.0155 0.0301
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.0667 0.066
Loa Loa (eye worm) hypothetical protein 0.0185 0.1107 0.1107
Entamoeba histolytica type A flavoprotein, putative 0.0579 0.3742 1
Loa Loa (eye worm) hypothetical protein 0.04 0.2544 0.2544
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0115 0.0638 0.0631
Schistosoma mansoni hypothetical protein 0.0039 0.0128 0.012
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0172 0.1017 0.0876
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0149 0.0866 0.0859
Echinococcus granulosus Partitioning defective 3 protein B 0.0039 0.0128 0.012
Trichomonas vaginalis aldo/keto reductase, putative 0.0149 0.0866 0.0722
Trypanosoma brucei nitrate reductase, putative 0.0172 0.1017 0.0961
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0043 0.0155 0.0147
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0149 0.0866 0.0859
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0115 0.0638 0.0638
Schistosoma mansoni hypothetical protein 0.0352 0.2222 0.2216
Loa Loa (eye worm) hypothetical protein 0.0115 0.0638 0.0638
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0071 0.0342 0.0335
Entamoeba histolytica alcohol dehydrogenase, putative 0.0043 0.0155 0.0225
Loa Loa (eye worm) hypothetical protein 0.04 0.2544 0.2544
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0048 0.0184 0.0029
Loa Loa (eye worm) hypothetical protein 0.0215 0.1302 0.1302
Brugia malayi metabotropic glutamate receptor type 2 0.0115 0.0638 0.0631
Brugia malayi Nuclear hormone receptor family member nhr-14 0.04 0.2544 0.2539
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1162 0.7645 0.7643
Echinococcus multilocularis thyroid hormone receptor alpha 0.04 0.2544 0.2539
Echinococcus granulosus myeloid:lymphoid or mixed lineage leukemia 0.0039 0.0128 0.012
Echinococcus multilocularis nuclear receptor nhr 48 0.0185 0.1107 0.1101
Echinococcus granulosus pdz domain containing protein 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0149 0.0866 0.0866
Schistosoma mansoni hypothetical protein 0.0048 0.0184 0.0176
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0149 0.0866 0.0859
Loa Loa (eye worm) DIX domain-containing protein 0.0039 0.0128 0.0128
Brugia malayi Protein-tyrosine phosphatase 0.0086 0.044 0.0433
Brugia malayi tailless protein 0.0185 0.1107 0.1101
Mycobacterium tuberculosis Probable monooxygenase 0.0172 0.1017 1
Toxoplasma gondii Erv1 / Alr family protein 0.003 0.0063 0.0113
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.04 0.2544 0.2539
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0149 0.0866 0.0859
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.04 0.2544 0.2544
Loa Loa (eye worm) hypothetical protein 0.0425 0.2714 0.2714
Loa Loa (eye worm) hypothetical protein 0.0115 0.0638 0.0638
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0048 0.0187 0.0032
Brugia malayi conserved hypotetical protein 0.0185 0.1107 0.1101
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.101
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0156 0.0908 0.0053
Brugia malayi PDZ domain containing protein 0.0039 0.0128 0.012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.04 0.2544 0.2539
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.003 0.0063 0.0055
Loa Loa (eye worm) hypothetical protein 0.0215 0.1302 0.1302
Loa Loa (eye worm) hypothetical protein 0.0215 0.1302 0.1302
Echinococcus granulosus partitioning defective 3 0.0039 0.0128 0.012
Brugia malayi intermediate filament protein 0.0023 0.0021 0.0013
Loa Loa (eye worm) hypothetical protein 0.04 0.2544 0.2544
Loa Loa (eye worm) RGC/RGC protein kinase 0.0115 0.0638 0.0638
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0185 0.1107 0.1101
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.04 0.2544 0.2539
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0024 0.0024 0.0016
Plasmodium falciparum nitric oxide synthase, putative 0.1513 1 1
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0043 0.0155 0.0147
Schistosoma mansoni syntrophin 0.0039 0.0128 0.012
Echinococcus granulosus segment polarity protein dishevelled 0.0039 0.0128 0.012
Echinococcus multilocularis voltage gated potassium channel subunit 0.0043 0.0155 0.0147
Trypanosoma cruzi aldo-keto reductase 0.0149 0.0866 0.0859
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0039 0.0128 0.012
Schistosoma mansoni hypothetical protein 0.0071 0.0342 0.0335
Loa Loa (eye worm) hypothetical protein 0.0181 0.108 0.108
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0048 0.0184 0.0333
Schistosoma mansoni tyrosine kinase 0.0115 0.0638 0.0631
Echinococcus granulosus NADPH cytochrome P450 reductase 0.1513 1 1
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0172 0.1017 0.101
Schistosoma mansoni aldo-keto reductase 0.0149 0.0866 0.0859
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Schistosoma mansoni glutamate receptor kainate 0.1046 0.6872 0.687
Echinococcus granulosus PDZ and LIM domain protein Zasp 0.0039 0.0128 0.012
Treponema pallidum flavodoxin 0.0579 0.3742 1
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0172 0.1017 0.101
Onchocerca volvulus 0.0039 0.0128 0.032
Onchocerca volvulus 0.0204 0.1234 0.3268
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.027 0.1671 0.1665
Brugia malayi Nuclear hormone receptor family member nhr-3 0.04 0.2544 0.2539
Schistosoma mansoni multiple pdz domain protein 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0185 0.1107 0.1107
Loa Loa (eye worm) glutamate receptor 1 0.1033 0.6787 0.6787
Loa Loa (eye worm) intermediate filament protein 0.0023 0.0021 0.0021
Echinococcus multilocularis cpg binding protein 0.0026 0.004 0.0032
Loa Loa (eye worm) hypothetical protein 0.0425 0.2714 0.2714
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0156 0.0908 0.2276
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0048 0.0184 0.0333
Giardia lamblia Hypothetical protein 0.1341 0.8848 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0185 0.1107 0.2932
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Schistosoma mansoni lin-7-like proteins 0.0039 0.0128 0.012
Schistosoma mansoni MAGUK homolog 0.004 0.013 0.0123
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0172 0.1017 1
Schistosoma mansoni hypothetical protein 0.0031 0.0073 0.0065
Entamoeba histolytica hypothetical protein 0.0077 0.0379 0.0836
Leishmania major NADH-dependent fumarate reductase, putative 0.0172 0.1017 0.101
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0115 0.0638 0.0631
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0048 0.0184 0.0122
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.0961
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.1513 1 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0024 0.0024 0.0016
Trichomonas vaginalis aldo-keto reductase, putative 0.0149 0.0866 0.0722
Entamoeba histolytica alcohol dehydrogenase, putative 0.0043 0.0155 0.0225
Echinococcus granulosus lamin dm0 0.0023 0.0021 0.0013
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.0961
Brugia malayi calpain family protein 1 0.0055 0.0236 0.0229
Schistosoma mansoni metabotropic glutamate receptor 0.0115 0.0638 0.0631
Schistosoma mansoni discs large 0.0039 0.0128 0.012
Trypanosoma brucei NADH-dependent fumarate reductase 0.0172 0.1017 0.0961
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0156 0.0908 0.0765
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0172 0.1017 0.2066
Echinococcus granulosus intermediate filament protein 0.0023 0.0021 0.0013
Brugia malayi RasGEF domain containing protein 0.0039 0.0128 0.012
Trypanosoma cruzi reductase, putative 0.0172 0.1017 0.101
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0149 0.0866 0.0859
Loa Loa (eye worm) hypothetical protein 0.04 0.2544 0.2544
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0172 0.1017 0.101
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0048 0.0184 0.0029
Loa Loa (eye worm) hypothetical protein 0.0115 0.0638 0.0638
Brugia malayi Nuclear hormone receptor-like 1 0.0215 0.1302 0.1295
Echinococcus granulosus peripheral plasma membrane protein CASK 0.004 0.013 0.0123
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.101
Trypanosoma cruzi aldo/keto reductase, putative 0.0043 0.0155 0.0147
Schistosoma mansoni thyroid hormone receptor 0.04 0.2544 0.2539
Schistosoma mansoni metabotropic glutamate receptor 0.0115 0.0638 0.0631
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0048 0.0184 0.0333
Schistosoma mansoni glutamate receptor NMDA 0.0724 0.4711 0.4707
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0225 0.1373 0.1366
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0048 0.0184 0.0333
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0172 0.1017 0.101
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0048 0.0184 0.0176
Echinococcus multilocularis geminin 0.0146 0.0842 0.0834
Trichomonas vaginalis aldo-keto reductase, putative 0.0149 0.0866 0.0722
Echinococcus multilocularis rho guanine nucleotide exchange factor 12 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0185 0.1107 0.1107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.04 0.2544 0.2539
Echinococcus multilocularis pdz domain containing protein 0.0039 0.0128 0.012
Mycobacterium ulcerans oxidoreductase 0.0172 0.1017 0.0876
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0579 0.3742 0.3643
Echinococcus multilocularis aldehyde reductase 0.0106 0.0576 0.0569
Leishmania major p450 reductase, putative 0.1513 1 1
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0039 0.0128 0.012
Echinococcus granulosus multiple pdz domain protein 0.0039 0.0128 0.012
Brugia malayi nuclear hormone receptor 0.04 0.2544 0.2539
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.0041 0.0033
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0039 0.0128 0.012
Loa Loa (eye worm) DR-78 0.0185 0.1107 0.1107
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0031 0.0073 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.04 0.2544 0.2539
Loa Loa (eye worm) calpain family protein 1 0.0055 0.0236 0.0236
Echinococcus granulosus SH3 and multiple ankyrin repeat domains protein 0.0039 0.0128 0.012
Echinococcus multilocularis methionine synthase reductase 0.0934 0.6123 0.612
Toxoplasma gondii Erv1 / Alr family protein 0.003 0.0063 0.0113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0041 0.0033
Echinococcus granulosus rho guanine nucleotide exchange factor 12 0.0039 0.0128 0.012
Trypanosoma cruzi cytochrome P450, putative 0.0106 0.0578 0.0571
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0077 0.0379 0.0379
Schistosoma mansoni hypothetical protein 0.0039 0.0128 0.012
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0185 0.1107 0.1101
Brugia malayi Abnormal embryonic partitioning of cytoplasm protein 3 0.0039 0.0128 0.012
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0185 0.1107 0.1101
Schistosoma mansoni NADPH flavin oxidoreductase 0.0762 0.4971 0.4967
Echinococcus multilocularis glutamate receptor 2 0.1033 0.6787 0.6784
Schistosoma mansoni maguk P55 subfamily member 26 0.0039 0.0128 0.012
Trypanosoma brucei NADH-dependent fumarate reductase 0.0172 0.1017 0.0961
Echinococcus multilocularis syndecan binding protein (syntenin) 0.0039 0.0128 0.012
Trypanosoma cruzi nitrate reductase, putative 0.0172 0.1017 0.101
Loa Loa (eye worm) hypothetical protein 0.0531 0.3422 0.3422
Schistosoma mansoni RAR-like nuclear receptor 0.04 0.2544 0.2539
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0215 0.1302 0.1295
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0039 0.0128 0.012
Echinococcus granulosus segment polarity protein dishevelled 0.0039 0.0128 0.012
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0039 0.0128 0.012
Brugia malayi Nuclear hormone receptor family member nhr-1 0.04 0.2544 0.2539
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0048 0.0184 0.0029
Echinococcus multilocularis SH3 and multiple ankyrin repeat domains protein 0.0039 0.0128 0.012
Echinococcus multilocularis cell polarity protein leucine rich repeat 0.0039 0.0128 0.012
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0048 0.0184 0.0029
Loa Loa (eye worm) AGC/MAST/MAST protein kinase 0.004 0.013 0.013
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0156 0.0908 0.0765
Schistosoma mansoni multiple pdz domain protein 0.0039 0.0128 0.012
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0149 0.0866 0.0722
Echinococcus multilocularis musashi 0.0023 0.0021 0.0013
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.1513 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0215 0.1302 0.1295
Echinococcus granulosus aldo keto reductase 0.0149 0.0866 0.0859
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0024 0.0024 0.0024
Plasmodium vivax aldehyde reductase, putative 0.0043 0.0155 0.0147
Brugia malayi Syntrophin-1 0.0039 0.0128 0.012
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0115 0.0638 0.0631
Loa Loa (eye worm) hypothetical protein 0.0115 0.0638 0.0638
Brugia malayi Steroid receptor seven-up type 2 0.04 0.2544 0.2539
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.003 0.0063 0.0055
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1162 0.7645 0.7643
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0156 0.0908 0.0908
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0579 0.3742 0.3737
Entamoeba histolytica type A flavoprotein, putative 0.0579 0.3742 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0024 0.0024 0.0016
Schistosoma mansoni hypothetical protein 0.0039 0.0128 0.012
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1162 0.7645 0.7643
Onchocerca volvulus 0.0149 0.0866 0.2287
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0172 0.1017 0.0876
Plasmodium falciparum aldo-keto reductase, putative 0.0043 0.0155 0.0147
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Brugia malayi cytochrome P450 0.0048 0.0184 0.0176
Echinococcus granulosus nmda type glutamate receptor 0.0225 0.1373 0.1366
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.1513 1 1
Echinococcus multilocularis MAGUK p55 subfamily 0.0039 0.0128 0.012
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0149 0.0866 0.0859
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0172 0.1017 0.101
Loa Loa (eye worm) hypothetical protein 0.0185 0.1107 0.1107
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0115 0.0638 0.168
Trypanosoma cruzi extracellular receptor, putative 0.0115 0.0638 0.0631
Schistosoma mansoni cell polarity protein 0.0039 0.0128 0.012
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0581 0.3759 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0048 0.0184 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-25 0.04 0.2544 0.2539
Echinococcus granulosus Rho GTPase activating protein 21 0.0039 0.0128 0.012
Echinococcus granulosus MAGUK p55 subfamily 0.0039 0.0128 0.012
Onchocerca volvulus Arc homolog 0.0039 0.0128 0.032
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Onchocerca volvulus 0.0185 0.1107 0.2932
Brugia malayi FAD binding domain containing protein 0.0934 0.6123 0.612
Brugia malayi Nuclear hormone receptor-like 1 0.0215 0.1302 0.1295
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0236 0.0229
Echinococcus granulosus Na:H exchange regulatory cofactor NHE RF2 0.0039 0.0128 0.012
Onchocerca volvulus 0.0039 0.0128 0.032
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0185 0.1107 0.2932
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.003 0.0063 0.0055
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0304 0.1901 0.1895
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0172 0.1017 0.101
Brugia malayi Cytochrome P450 family protein 0.0048 0.0184 0.0176
Trichomonas vaginalis aldo/keto reductase, putative 0.0149 0.0866 0.0722
Echinococcus granulosus MAGUK p55 subfamily 0.0039 0.0128 0.012
Echinococcus granulosus nmda type glutamate receptor 0.0115 0.0638 0.0631
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0048 0.0184 0.0029
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0039 0.0128 0.012
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0039 0.0128 0.012
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0172 0.1017 0.101
Onchocerca volvulus 0.0149 0.0866 0.2287
Echinococcus granulosus PRKCA binding protein 0.0039 0.0128 0.012
Schistosoma mansoni nuclear hormone receptor 0.0185 0.1107 0.1101
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0039 0.0128 0.012
Trichomonas vaginalis set domain proteins, putative 0.0204 0.1234 0.1096
Onchocerca volvulus 0.0039 0.0126 0.0315
Brugia malayi hypothetical protein 0.0039 0.0128 0.012
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0156 0.0908 0.0765
Brugia malayi hypothetical protein 0.0031 0.0073 0.0065
Toxoplasma gondii histone lysine methyltransferase SET1 0.0048 0.0185 0.0363
Mycobacterium tuberculosis Probable oxidoreductase 0.0149 0.0866 0.8241
Loa Loa (eye worm) FAD binding domain-containing protein 0.1513 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0342 0.0342
Echinococcus granulosus voltage gated potassium channel subunit 0.0043 0.0155 0.0147
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.0041 0.0068
Echinococcus multilocularis dual specificity 0.0077 0.0379 0.0372
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.003 0.0063 0.0055
Onchocerca volvulus Bile acid receptor homolog 0.0531 0.3422 0.9101
Schistosoma mansoni intermediate filament proteins 0.0023 0.0021 0.0013
Giardia lamblia Flavohemoprotein lateral transfer candidate 0.0172 0.1017 0.019
Loa Loa (eye worm) glutamate receptor 2 0.0608 0.3938 0.3938
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0048 0.0184 0.0333
Brugia malayi CXXC zinc finger family protein 0.0025 0.0031 0.0023
Brugia malayi hypothetical protein 0.0039 0.0128 0.012
Loa Loa (eye worm) guanylate kinase 0.0039 0.0128 0.0128
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0008 0.0008
Echinococcus multilocularis neuropeptide s receptor 0.0403 0.2567 0.2561
Schistosoma mansoni lamin 0.0023 0.0021 0.0013
Schistosoma mansoni zinc finger protein 0.0185 0.1107 0.1101
Loa Loa (eye worm) hypothetical protein 0.0185 0.1107 0.1107
Brugia malayi Guanylyl cyclase protein 23 0.0115 0.0638 0.0631
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0043 0.0155 0.0147
Plasmodium vivax SET domain protein, putative 0.0026 0.0041 0.0033
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Loa Loa (eye worm) calpain family protein 1 0.0039 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0185 0.1107 0.1107
Echinococcus granulosus cytochrome b5 reductase 4 0.0172 0.1017 0.101
Brugia malayi Metabotropic glutamate receptor precursor. 0.0115 0.0638 0.0631
Schistosoma mansoni pdz and lim domain protein 0.0039 0.0128 0.012
Mycobacterium leprae putative cytochrome p450 0.0048 0.0184 0.0404
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0048 0.0184 0.0029
Brugia malayi PX domain containing protein 0.0039 0.0128 0.012
Mycobacterium tuberculosis Possible oxygenase 0.0172 0.1017 1
Entamoeba histolytica protein kinase domain containing protein 0.0077 0.0379 0.0836
Echinococcus multilocularis PDZ domain containing protein GIPC3 0.0039 0.0128 0.012
Toxoplasma gondii flavodoxin domain-containing protein 0.0751 0.4894 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0149 0.0866 0.0859
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0149 0.0866 0.0859
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.04 0.2544 0.2539
Loa Loa (eye worm) syntrophin-1 0.0039 0.0128 0.0128
Brugia malayi Pre-SET motif family protein 0.018 0.1068 0.1061
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Schistosoma mansoni tight junction protein 0.0039 0.0128 0.012
Echinococcus granulosus dnaJ subfamily B 0.0352 0.2222 0.2216
Echinococcus granulosus nuclear receptor 2DBD gamma 0.04 0.2544 0.2539
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0185 0.1107 0.1101
Loa Loa (eye worm) hypothetical protein 0.0185 0.1107 0.1107
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0048 0.0184 0.0333
Brugia malayi Ferm domain 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Echinococcus granulosus calpain A 0.0058 0.0255 0.0248
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0172 0.1017 0.0961
Brugia malayi nuclear hormone receptor 0.0367 0.2322 0.2316
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0077 0.0379 0.0372
Loa Loa (eye worm) PAR-6 protein 0.0039 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0039 0.0128 0.012
Schistosoma mansoni amyloid beta A4 protein related 0.0039 0.0128 0.012
Brugia malayi DIX domain containing protein 0.0039 0.0128 0.012
Onchocerca volvulus 0.0039 0.0128 0.032
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0149 0.0866 0.0859
Echinococcus multilocularis nmda type glutamate receptor 0.0115 0.0638 0.0631
Echinococcus multilocularis protein lin 7 B 0.0039 0.0128 0.012
Brugia malayi flavodoxin family protein 0.0579 0.3742 0.3737
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0024 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.0425 0.2714 0.2714
Trypanosoma cruzi cytochrome P450 reductase, putative 0.1513 1 1
Onchocerca volvulus Big bang homolog 0.0039 0.0128 0.032
Leishmania major hypothetical protein, conserved 0.0579 0.3742 0.3737
Loa Loa (eye worm) hypothetical protein 0.0039 0.0126 0.0126
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0039 0.0128 0.012
Schistosoma mansoni microtubule-associated protein tau 0.0594 0.3841 0.3837
Onchocerca volvulus 0.0149 0.0866 0.2287
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0039 0.0128 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0379 0.0372
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.101
Loa Loa (eye worm) hepatopoietin HPO2 0.003 0.0063 0.0063
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0039 0.0128 0.012
Echinococcus granulosus glutamate receptor 2 0.1149 0.756 0.7558
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0149 0.0866 0.0859
Echinococcus granulosus lamin 0.0023 0.0021 0.0013
Brugia malayi Protein-tyrosine phosphatase 1 0.0059 0.026 0.0252
Onchocerca volvulus Protein ultraspiracle homolog 0.04 0.2544 0.6762
Loa Loa (eye worm) hypothetical protein 0.0115 0.0638 0.0638
Echinococcus granulosus glutamate NMDA receptor subunit 0.0608 0.3938 0.3934
Schistosoma mansoni dishevelled 0.0039 0.0128 0.012
Echinococcus granulosus tyrosine kinase 0.0115 0.0638 0.0631
Entamoeba histolytica aldose reductase, putative 0.0149 0.0866 0.2162
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0058 0.0255 0.0248
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.04 0.2544 0.2544
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.04 0.2544 0.2539
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0048 0.0184 0.0333
Loa Loa (eye worm) hypothetical protein 0.0185 0.1107 0.1107
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Onchocerca volvulus 0.0023 0.0021 0.0034
Echinococcus granulosus tight junction protein ZO 3 0.0039 0.0128 0.012
Trichomonas vaginalis aldo/keto reductase, putative 0.0149 0.0866 0.0722
Echinococcus multilocularis dnaJ subfamily B 0.0352 0.2222 0.2216
Brugia malayi hypothetical protein 0.0185 0.1107 0.1101
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.1341 0.8848 0.883
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0172 0.1017 1
Brugia malayi Cytochrome P450 family protein 0.0106 0.0578 0.0571
Schistosoma mansoni cpg binding protein 0.0025 0.0031 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.04 0.2544 0.2539
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.04 0.2544 0.2539
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0115 0.0638 0.0631
Leishmania major NADH-dependent fumarate reductase-like protein 0.0172 0.1017 0.101
Loa Loa (eye worm) hypothetical protein 0.0076 0.0377 0.0377
Loa Loa (eye worm) CXXC zinc finger family protein 0.0025 0.0031 0.0031
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0149 0.0866 0.0859
Loa Loa (eye worm) CYP4Cod1 0.0106 0.0578 0.0578
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0048 0.0184 0.0029
Schistosoma mansoni PDZ domain protein 0.0039 0.0128 0.012
Brugia malayi Augmenter of liver regeneration 0.003 0.0063 0.0055
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.04 0.2544 0.2539
Loa Loa (eye worm) cytochrome P450 0.0048 0.0184 0.0184
Schistosoma mansoni sap-97 0.0039 0.0128 0.012
Loa Loa (eye worm) oxidoreductase 0.0149 0.0866 0.0866
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Echinococcus multilocularis PRKCA binding protein 0.0039 0.0128 0.012
Leishmania major hypothetical protein, conserved 0.0048 0.0187 0.0179
Entamoeba histolytica protein kinase, putative 0.0077 0.0379 0.0836
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0048 0.0184 0.0029
Trichomonas vaginalis aldo-keto reductase, putative 0.0149 0.0866 0.0722
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.101
Trichomonas vaginalis aldo-keto reductase, putative 0.0149 0.0866 0.0722
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0304 0.1901 0.1895
Schistosoma mansoni apoptosis regulator bax 0.0071 0.0342 0.0335
Trypanosoma cruzi p450 reductase, putative 0.0172 0.1017 0.101
Loa Loa (eye worm) steroid hormone receptor 0.04 0.2544 0.2544
Entamoeba histolytica type A flavoprotein, putative 0.0579 0.3742 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0149 0.0866 0.0722
Loa Loa (eye worm) nuclear hormone receptor 0.0185 0.1107 0.1107
Schistosoma mansoni leucine-rich repeat protein 0.0039 0.0128 0.012
Toxoplasma gondii aldose reductase, putative 0.0149 0.0866 0.1756
Loa Loa (eye worm) oxidoreductase 0.0149 0.0866 0.0866
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0149 0.0866 0.0859
Echinococcus granulosus hypothetical protein 0.0149 0.0866 0.0859
Trichomonas vaginalis aldo-keto reductase, putative 0.0149 0.0866 0.0722
Brugia malayi Nuclear hormone receptor family member nhr-19 0.04 0.2544 0.2539
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0484 0.3108 0.3103
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0934 0.6123 0.612
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0043 0.0155 0.0301
Loa Loa (eye worm) PDZ-domain-containing protein scribble 0.0039 0.0128 0.0128
Onchocerca volvulus 0.0149 0.0866 0.2287
Schistosoma mansoni glutamate receptor AMPA 0.0608 0.3938 0.3934
Echinococcus granulosus FTZ F1 alpha 0.04 0.2544 0.2539
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0156 0.0908 0.0765
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.04 0.2544 0.2539
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0048 0.0184 0.0333
Schistosoma mansoni hypothetical protein 0.0071 0.0342 0.0335
Schistosoma mansoni Patj homolog 0.0039 0.0128 0.012
Echinococcus multilocularis calpain A 0.0058 0.0255 0.0248
Schistosoma mansoni cytochrome B5 0.0172 0.1017 0.101
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0071 0.0342 0.0335
Entamoeba histolytica type A flavoprotein, putative 0.0579 0.3742 1
Echinococcus multilocularis multiple pdz domain protein 0.0039 0.0128 0.012
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0579 0.3742 0.3643
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0041 0.0033
Brugia malayi gopc protein 0.0039 0.0128 0.012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.04 0.2544 0.2539
Loa Loa (eye worm) hypothetical protein 0.04 0.2544 0.2544
Loa Loa (eye worm) hypothetical protein 0.0115 0.0638 0.0638
Brugia malayi Nuclear hormone receptor E75 0.0185 0.1107 0.1101
Echinococcus multilocularis Partitioning defective 3 protein B 0.0039 0.0128 0.012
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0071 0.0342 0.0335
Echinococcus granulosus microtubule associated protein 2 0.0594 0.3841 0.3837
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0172 0.1017 0.101
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0149 0.0866 0.0859
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0039 0.0126 0.0126
Schistosoma mansoni protein tyrosine phosphatase 0.0024 0.0024 0.0016
Schistosoma mansoni glutamate receptor kainate 0.1046 0.6872 0.687
Trichomonas vaginalis aldo-keto reductase, putative 0.0149 0.0866 0.0722
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0048 0.0184 0.0029
Brugia malayi PDZ domain containing protein 0.0039 0.0128 0.012
Echinococcus multilocularis cytochrome b5 reductase 4 0.0172 0.1017 0.101
Schistosoma mansoni pdz domain containing protein 0.0039 0.0128 0.012
Brugia malayi Cytochrome P450 family protein 0.0106 0.0578 0.0571
Schistosoma mansoni afadin (af-6 protein) 0.0039 0.0128 0.012
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0185 0.1107 0.1101
Entamoeba histolytica hypothetical protein 0.0115 0.0638 0.1541
Leishmania major cytochrome p450-like protein 0.0048 0.0184 0.0176
Brugia malayi Trypsin family protein 0.012 0.0667 0.066
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0225 0.1373 0.1366
Loa Loa (eye worm) nuclear receptor NHR-67 0.0185 0.1107 0.1107
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0024 0.0024 0.0016
Echinococcus granulosus dual specificity 0.0077 0.0379 0.0372
Brugia malayi Nuclear hormone receptor E75 0.0185 0.1107 0.1101
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0048 0.0187 0.0124
Loa Loa (eye worm) diaphorase 0.0172 0.1017 0.1017
Schistosoma mansoni aldo-keto reductase 0.0149 0.0866 0.0859
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0071 0.0342 0.0335
Echinococcus multilocularis receptor type guanylyl cyclase 0.0115 0.0638 0.0631
Loa Loa (eye worm) MH2 domain-containing protein 0.0103 0.0553 0.0553
Brugia malayi hypothetical protein 0.0039 0.0128 0.012
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.004 0.013 0.0123
Loa Loa (eye worm) cytochrome P450 family protein 0.0106 0.0578 0.0578
Brugia malayi PDZ domain containing protein 0.0039 0.0128 0.012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.04 0.2544 0.2539
Loa Loa (eye worm) hypothetical protein 0.0115 0.0638 0.0638
Echinococcus multilocularis lamin 0.0023 0.0021 0.0013
Loa Loa (eye worm) oxidoreductase 0.0149 0.0866 0.0866
Echinococcus granulosus disks large 1 0.0039 0.0128 0.012
Brugia malayi syntenin 0.0039 0.0128 0.012
Schistosoma mansoni nuclear receptor 0.0185 0.1107 0.1101
Echinococcus granulosus methionine synthase reductase 0.0934 0.6123 0.612
Loa Loa (eye worm) hypothetical protein 0.0062 0.0281 0.0281
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0172 0.1017 0.101
Echinococcus multilocularis disks large 3 0.0039 0.0128 0.012
Schistosoma mansoni protein kinase 0.0115 0.0638 0.0631
Trypanosoma brucei aldo/keto reductase, putative 0.0043 0.0155 0.0093
Leishmania major prostaglandin f synthase, putative 0.0149 0.0866 0.0859
Trichomonas vaginalis aldo-keto reductase, putative 0.0149 0.0866 0.0722
Onchocerca volvulus 0.0039 0.0128 0.032
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0579 0.3742 0.3643
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0172 0.1017 0.101
Echinococcus multilocularis multiple pdz domain protein 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0185 0.1107 0.1107
Schistosoma mansoni lim domain 0.0039 0.0128 0.012
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0172 0.1017 0.101
Schistosoma mansoni hypothetical protein 0.0039 0.0128 0.012
Echinococcus multilocularis neuropeptide receptor A26 0.0403 0.2567 0.2561
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0172 0.1017 0.101
Echinococcus multilocularis myeloid:lymphoid or mixed lineage leukemia 0.0039 0.0128 0.012
Echinococcus granulosus neurabin 1 0.0039 0.0128 0.012
Echinococcus granulosus cytochrome b5 reductase 4 0.0172 0.1017 0.101
Schistosoma mansoni hypothetical protein 0.0039 0.0128 0.012
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0156 0.0908 0.0765
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0025 0.0031 0.0023
Loa Loa (eye worm) gopc protein 0.0039 0.0128 0.0128
Brugia malayi nuclear receptor RXR 0.0215 0.1302 0.1295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.04 0.2544 0.2544
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Schistosoma mansoni lamin 0.0023 0.0021 0.0013
Loa Loa (eye worm) 9ORF binding protein 1 0.0039 0.0128 0.0128
Brugia malayi interleukin-16 0.0039 0.0128 0.012
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0077 0.0379 0.0372
Brugia malayi Nuclear hormone receptor family member nhr-31 0.04 0.2544 0.2539
Loa Loa (eye worm) hypothetical protein 0.0059 0.026 0.026
Trypanosoma cruzi cytochrome P450 reductase, putative 0.1513 1 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0048 0.0184 0.0029
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.04 0.2544 0.2539
Loa Loa (eye worm) hypothetical protein 0.0055 0.0236 0.0236
Brugia malayi nuclear receptor NHR-88 0.04 0.2544 0.2539
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0115 0.0638 0.0638
Brugia malayi ecdysone receptor 0.0185 0.1107 0.1101
Echinococcus multilocularis glutamate receptor subunit protein glur 0.065 0.4221 0.4216
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.0021 0.0013
Echinococcus granulosus multiple pdz domain protein 0.0039 0.0128 0.012
Onchocerca volvulus 0.0149 0.0866 0.2287
Entamoeba histolytica aldose reductase, putative 0.0149 0.0866 0.2162
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0255 0.0248
Echinococcus granulosus geminin 0.0146 0.0842 0.0834
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0149 0.0866 0.0859
Loa Loa (eye worm) PDZ domain-containing protein 0.0039 0.0128 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.04 0.2544 0.2544
Brugia malayi Hypothetical 13.5 kDa protein C45G9.7 in chromosome III 0.0039 0.0128 0.012
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0663 0.4306 0.4302
Echinococcus granulosus atrial natriuretic peptide receptor 0.0115 0.0638 0.0631
Schistosoma mansoni hypothetical protein 0.0146 0.0842 0.0834
Brugia malayi hypothetical protein 0.0115 0.0638 0.0631
Schistosoma mansoni glutamate receptor AMPA 0.0608 0.3938 0.3934
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Echinococcus multilocularis Rho GTPase activating protein 21 0.0039 0.0128 0.012
Schistosoma mansoni tyrosine kinase 0.0115 0.0638 0.0631
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0187 0.0179
Brugia malayi PDZ-domain protein scribble 0.0039 0.0128 0.012
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0077 0.0379 0.0372
Echinococcus granulosus Nuclear hormone receptor HR96 0.0185 0.1107 0.1101
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0048 0.0184 0.0333
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0059 0.026 0.026
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0039 0.0128 0.012
Brugia malayi hypothetical protein 0.0039 0.0128 0.012
Brugia malayi Neurabin protein 1 0.0039 0.0128 0.012
Echinococcus multilocularis Na(+):H(+) exchange regulatory cofactor NHE RF2 0.0039 0.0128 0.012
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0255 0.0248
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.0041 0.0033
Entamoeba histolytica aldose reductase, putative 0.0149 0.0866 0.2162
Echinococcus multilocularis partitioning defective 3 0.0039 0.0128 0.012
Loa Loa (eye worm) PX domain-containing protein 0.0039 0.0128 0.0128
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0043 0.0155 0.0147
Echinococcus multilocularis glutamate receptor interacting protein 1 0.0039 0.0128 0.012
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0156 0.0908 0.0765
Trypanosoma cruzi cytochrome P450, putative 0.0106 0.0578 0.0571
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0172 0.1017 0.101
Schistosoma mansoni maguk P55 subfamily member 35 0.0039 0.0128 0.012
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0048 0.0184 0.0029
Trypanosoma brucei cytochrome P450, putative 0.0106 0.0578 0.0518
Echinococcus multilocularis aldo keto reductase 0.0149 0.0866 0.0859
Leishmania major extracellular receptor, putative 0.0115 0.0638 0.0631
Echinococcus multilocularis PDZ and LIM domain protein Zasp 0.0039 0.0128 0.012
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0304 0.1901 0.1895
Echinococcus granulosus MAGUK p55 subfamily 0.0039 0.0128 0.012
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0156 0.0908 0.0901
Mycobacterium ulcerans oxidoreductase 0.0149 0.0866 0.0722
Brugia malayi protein kinase C-binding protein PICK1 0.0039 0.0128 0.012
Brugia malayi Shank2E 0.0039 0.0128 0.012
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.0961
Echinococcus granulosus cytochrome P450 2K1 0.0048 0.0184 0.0176
Schistosoma mansoni syntenin 0.0039 0.0128 0.012
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0172 0.1017 0.1484
Echinococcus granulosus nuclear receptor nhr 48 0.0185 0.1107 0.1101
Loa Loa (eye worm) hypothetical protein 0.0082 0.0413 0.0413
Schistosoma mansoni transcription factor LCR-F1 0.0031 0.0073 0.0065
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0149 0.0866 0.0859
Leishmania major NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.101
Echinococcus granulosus glutamate receptor 4 0.0425 0.2714 0.2708
Schistosoma mansoni hypothetical protein 0.0071 0.0342 0.0335
Echinococcus granulosus glutamate receptor 1 0.0425 0.2714 0.2708
Brugia malayi hypothetical protein 0.0185 0.1107 0.1101
Brugia malayi photoreceptor-specific nuclear receptor 0.04 0.2544 0.2539
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.1513 1 1
Echinococcus multilocularis aldo keto reductase 0.0149 0.0866 0.0859
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0048 0.0184 0.0333
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1162 0.7645 0.7643
Onchocerca volvulus 0.0039 0.0128 0.032
Trypanosoma brucei prostaglandin f synthase 0.0149 0.0866 0.0808
Echinococcus multilocularis segment polarity protein dishevelled 0.0039 0.0128 0.012
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0149 0.0866 0.0859
Echinococcus multilocularis calpain family protein 1, d 0.0039 0.0126 0.0118
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0149 0.0866 0.0859
Echinococcus granulosus multiple pdz domain protein 0.0039 0.0128 0.012
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0048 0.0184 0.0176
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.1149 0.756 0.7558
Brugia malayi Protein kinase domain containing protein 0.0077 0.0379 0.0372
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.1513 1 1
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.101
Echinococcus granulosus neuropeptide receptor A26 0.0403 0.2567 0.2561
Schistosoma mansoni cpg binding protein 0.0026 0.004 0.0032
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0039 0.0128 0.032
Entamoeba histolytica type A flavoprotein, putative 0.0579 0.3742 1
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.1513 1 1
Echinococcus granulosus aldehyde reductase 0.0106 0.0576 0.0569
Loa Loa (eye worm) hypothetical protein 0.04 0.2544 0.2544
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0039 0.0128 0.0128
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0156 0.0908 0.0765
Brugia malayi steroid hormone receptor 0.04 0.2544 0.2539
Schistosoma mansoni leucine-rich repeat protein 0.0039 0.0128 0.012
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0149 0.0866 0.0859
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0172 0.1017 0.0961
Echinococcus multilocularis lamin dm0 0.0023 0.0021 0.0013
Brugia malayi rho guanine nucleotide exchange factor 12 0.0039 0.0128 0.012
Brugia malayi Glutamate receptor 2 precursor 0.1033 0.6787 0.6784
Echinococcus granulosus glutamate receptor interacting protein 1 0.0039 0.0128 0.012
Onchocerca volvulus 0.012 0.0667 0.1758
Echinococcus multilocularis partitioning defective protein 6 0.0039 0.0128 0.012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.04 0.2544 0.2539
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0149 0.0866 0.0859
Echinococcus granulosus pdz domain containing protein 0.0039 0.0128 0.012
Trichomonas vaginalis aldo-keto reductase, putative 0.0149 0.0866 0.0722
Schistosoma mansoni nuclear receptor nhr-48 0.0185 0.1107 0.1101
Onchocerca volvulus 0.0039 0.0128 0.032
Leishmania major cytochrome p450-like protein 0.0048 0.0184 0.0176
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0071 0.0342 0.0335
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.003 0.0063 0.0055
Brugia malayi FAD binding domain containing protein 0.1513 1 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0149 0.0866 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0367 0.2322 0.2322
Onchocerca volvulus 0.0106 0.0578 0.1519
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.0961
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0039 0.0128 0.012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.1513 1 1
Leishmania major cytochrome-b5 reductase, putative 0.0172 0.1017 0.101
Onchocerca volvulus 0.0026 0.0041 0.0088
Echinococcus granulosus glutamate receptor 2 0.0924 0.6052 0.6049
Onchocerca volvulus 0.0039 0.0128 0.032
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0149 0.0866 0.0859
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0172 0.1017 0.101
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0579 0.3742 0.3737
Echinococcus granulosus cpg binding protein 0.0026 0.004 0.0032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.04 0.2544 0.2539
Schistosoma mansoni multiple pdz domain protein 0.0039 0.0128 0.012
Schistosoma mansoni hypothetical protein 0.0039 0.0128 0.012
Echinococcus granulosus aldo keto reductase 0.0149 0.0866 0.0859
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.1513 1 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0667 0.0667
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.04 0.2544 0.2544
Schistosoma mansoni glutamate receptor kainate 0.0608 0.3938 0.3934
Brugia malayi PDZ domain containing protein 0.0039 0.0128 0.012

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.0313 uM In vitro inhibition of human coagulation factor Xa. ChEMBL. 11677132
IC50 (binding) = 0.0313 uM In vitro inhibition of human coagulation factor Xa. ChEMBL. 11677132
IC50 (binding) > 10 uM In vitro inhibition of human thrombin. ChEMBL. 11677132
IC50 (binding) > 10 uM In vitro inhibition of human trypsin. ChEMBL. 11677132
IC50 (binding) > 10 uM In vitro inhibition of human thrombin. ChEMBL. 11677132
IC50 (binding) > 10 uM In vitro inhibition of human trypsin. ChEMBL. 11677132

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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