Detailed information for compound 233111

Basic information

Technical information
  • TDR Targets ID: 233111
  • Name: 1,2-Dithiolane-3R-pentanoic acid
  • MW: 206.326 | Formula: C8H14O2S2
  • H donors: 1 H acceptors: 2 LogP: 1.68 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCCC[C@H]1SSCC1
  • InChi: 1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
  • InChiKey: AGBQKNBQESQNJD-SSDOTTSWSA-N  


Substructure search Similarity search

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Synonyms

  • 5-[(3R)-dithiolan-3-yl]pentanoic acid
  • Lipoate
  • Lipoic Acid
  • Thioctic acid
  • alpha-Lipoic acid
  • 5-[(3R)-3-dithiolanyl]pentanoic acid
  • 5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid
  • 5-[(3R)-dithiolan-3-yl]valeric acid
  • 1200-22-2
  • AIDS-003362
  • LPA
  • AIDS003362
  • Thioctanoic acid
  • (+)-alpha-Lipoic acid
  • (R)-(+)-lipoic acid
  • (R)-1,2-Dithiolane-3-pentanoic acid
  • (R)-lipoic acid
  • CHEBI:30314
  • Thioctic acid d-form
  • 1,2-Dithiolane-3-pentanoic acid, (R)-
  • R-Lipoate
  • .alpha.-Lipoic acid
  • 5-(1,2-Dithiolan-3-yl)valeric acid
  • 5-19-07-00237 (Beilstein Handbook Reference)
  • (R)-()-1,2-Dithiolane-3-pentanoic acid
  • 6,8-Thioctic acid
  • 6,8-Thiotic acid
  • 6-Thioctic acid
  • 6-Thiotic acid
  • Acetate-replacing factor
  • BRN 0122410
  • NCGC00094396-03
  • DRG-0236
  • EINECS 200-534-6
  • Heparlipon
  • Liposan
  • Lipothion
  • Protogen A
  • Pyruvate oxidation factor
  • Thioctacid
  • Thioctic acid [JAN]
  • Thioctidase
  • Thioctsan
  • Thioktsaeure [German]
  • Thiooctanoic acid
  • Tioctacid
  • Tioctidasi
  • Tioctidasi acetate replacing factor
  • alpha-Liponsaeure [German]
  • (R)-(+)-Lipoate
  • C16241
  • R-(+)-Lipoic acid
  • 579602_ALDRICH
  • Lopac0_001129
  • LMFA01130001
  • R-Lipoic acid
  • EU-0101129
  • STOCK1N-43250

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens acetylcholinesterase (Yt blood group) Starlite/ChEMBL References
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Rattus norvegicus Alpha-1a adrenergic receptor Starlite/ChEMBL References
Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Escherichia coli endonuclease IV with intrinsic 3'-5' exonuclease activity Starlite/ChEMBL No references
Homo sapiens nuclear receptor subfamily 1, group I, member 2 Starlite/ChEMBL References
Rattus norvegicus Alpha-1b adrenergic receptor Starlite/ChEMBL References
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Rattus norvegicus Alpha-1d adrenergic receptor Starlite/ChEMBL References
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis apurinic/apyrimidinic endonuclease Apn1 Get druggable targets OG5_129467 All targets in OG5_129467
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii AP endonuclease 1 Get druggable targets OG5_129467 All targets in OG5_129467
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Chlamydia trachomatis endonuclease IV Get druggable targets OG5_129467 All targets in OG5_129467
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum endonuclease V, putative Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans apurinic/apyrimidinic endonuclease/3'-repair diesterase Get druggable targets OG5_129467 All targets in OG5_129467
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans endonuclease IV Get druggable targets OG5_129467 All targets in OG5_129467
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) Get druggable targets OG5_129467 All targets in OG5_129467
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni amine GPCR Get druggable targets OG5_128924 All targets in OG5_128924
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) Get druggable targets OG5_129467 All targets in OG5_129467
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii endonuclease IV APN Get druggable targets OG5_129467 All targets in OG5_129467
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Babesia bovis apurinic endonuclease (APN1) family protein Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_129467 All targets in OG5_129467
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium berghei apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Cryptosporidium parvum AP endonuclease of the TIM barrel fold, possible bacterial horizontal transfer Get druggable targets OG5_129467 All targets in OG5_129467
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Alpha-1D adrenergic receptor, putative Get druggable targets OG5_128924 All targets in OG5_128924
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129467 All targets in OG5_129467
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Brugia malayi Carboxylesterase family protein acetylcholinesterase (Yt blood group) 614 aa 510 aa 26.5 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Echinococcus multilocularis g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 398 aa 21.4 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Echinococcus granulosus g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 399 aa 20.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Echinococcus multilocularis g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 414 aa 20.3 %
Schistosoma japonicum FMRFamide receptor, putative Alpha-1a adrenergic receptor   466 aa 374 aa 19.5 %
Brugia malayi ecdysteroid receptor nuclear receptor subfamily 1, group I, member 2 434 aa 427 aa 25.1 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Alpha-1a adrenergic receptor   466 aa 443 aa 31.2 %
Echinococcus granulosus g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 414 aa 20.5 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Alpha-1a adrenergic receptor   466 aa 386 aa 31.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Echinococcus granulosus rhodopsin orphan GPCR Alpha-1a adrenergic receptor   466 aa 418 aa 20.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Onchocerca volvulus Alpha-1b adrenergic receptor   515 aa 429 aa 20.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Echinococcus granulosus biogenic amine 5HT receptor Alpha-1a adrenergic receptor   466 aa 418 aa 30.4 %
Echinococcus multilocularis neuropeptide Y receptor Alpha-1a adrenergic receptor   466 aa 419 aa 19.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus G protein coupled receptor 139 0.0048 0.016 0.0311
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0286 0.1564 0.2997
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Brugia malayi photoreceptor-specific nuclear receptor 0.0046 0.0148 0.0274
Brugia malayi phosphofructokinase 0.0131 0.0653 0.1244
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0589 0.1173
Onchocerca volvulus 0.0036 0.0091 0.028
Leishmania major hypothetical protein, conserved 0.0028 0.0044 0.0065
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0119 0.0228
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0218 0.0427
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0255 0.05
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0011
Onchocerca volvulus 0.008 0.0349 0.1133
Echinococcus granulosus neuropeptide receptor 0.0048 0.016 0.0311
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0215 0.0496
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Brugia malayi hypothetical protein 0.0024 0.0021 0.0029
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0361 0.0356
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0134 0.0259
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Plasmodium vivax hypothetical protein, conserved 0.008 0.0349 0.8015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Brugia malayi sulfakinin receptor protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0046 0.0148 0.0143
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0903 0.5207 1
Brugia malayi Pre-SET motif family protein 0.0066 0.0269 0.0506
Echinococcus multilocularis allatostatin A receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0029 0.0045
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Brugia malayi steroid hormone receptor 0.0046 0.0148 0.0274
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus neuropeptide s receptor 0.0048 0.016 0.0311
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.008 0.0349 0.0343
Loa Loa (eye worm) hypothetical protein 0.0053 0.0194 0.0362
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0181 0.0374
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0058 0.0222 0.4671
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0269 0.0529
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.016 0.0311
Brugia malayi Carboxylesterase family protein 0.0082 0.0361 0.0684
Schistosoma mansoni hypothetical protein 0.0865 0.4979 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0349 0.0343
Schistosoma mansoni DNA helicase recq5 0.0035 0.0082 0.0154
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0046 0.0148 0.0287
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0077 0.0137
Brugia malayi hypothetical protein 0.0535 0.3033 0.5821
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0048 0.016 0.0155
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0349 0.069
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni steroid hormone receptor ad4bp 0.0046 0.0148 0.0287
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0234 0.1261 0.2524
Echinococcus granulosus bloom syndrome protein 0.005 0.0172 0.0333
Loa Loa (eye worm) glutaminase 2 0.0317 0.1747 0.3348
Loa Loa (eye worm) glutathione reductase 0.0057 0.0215 0.0403
Mycobacterium tuberculosis Probable reductase 0.013 0.0647 0.1605
Onchocerca volvulus 0.0032 0.0066 0.0198
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0021 0.0031
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus multilocularis G-protein coupled receptor, putative 0.0048 0.016 0.0155
Echinococcus multilocularis lamin 0.0033 0.007 0.0065
Onchocerca volvulus 0.0048 0.016 0.0511
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0091 0.0176
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.016 0.0311
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.007 0.0124
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.016 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0046 0.0148 0.0274
Echinococcus multilocularis geminin 0.0865 0.4979 0.4976
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0096 0.0182
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.008 0.0349 0.0343
Echinococcus multilocularis serotonin receptor 0.0299 0.1641 0.1637
Brugia malayi Smad1 0.0026 0.0029 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.039 0.0774
Echinococcus granulosus g-protein coupled receptor 0.0048 0.016 0.0311
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0088 0.1142
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0176
Schistosoma mansoni smad 0.0026 0.0029 0.0047
Schistosoma mansoni smad1 5 8 and 0.0026 0.0029 0.0047
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0349 0.069
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0349 0.4619
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.008 0.0349 0.066
Loa Loa (eye worm) norepinephrine transporter 0.047 0.265 0.5084
Echinococcus multilocularis sex peptide receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0096 0.0173
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Brugia malayi G protein-coupled receptor 0.0048 0.016 0.0298
Onchocerca volvulus Bile acid receptor homolog 0.0046 0.0148 0.0471
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0112 0.1809
Onchocerca volvulus 0.0033 0.007 0.0214
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0218 0.0702
Schistosoma mansoni opsin-like receptor 0.0048 0.016 0.0311
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0082 0.0361 0.0684
Trichomonas vaginalis DNA helicase recq1, putative 0.005 0.0172 0.0291
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Leishmania major trypanothione reductase 0.0057 0.0215 0.0451
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0281 0.1534 0.2939
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.016 0.0298
Echinococcus multilocularis lamin dm0 0.0033 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0148 0.0274
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.008 0.0349 0.0343
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0057 0.0213 0.0507
Treponema pallidum quinoline 2-oxidoreductase 0.0027 0.0036 0.0093
Loa Loa (eye worm) hypothetical protein 0.0045 0.0142 0.0263
Loa Loa (eye worm) hypothetical protein 0.0149 0.0759 0.1448
Brugia malayi neuropeptide F receptor 0.0048 0.016 0.0298
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Brugia malayi acetyltransferase, GNAT family protein 0.0178 0.0928 0.1773
Brugia malayi hypothetical protein 0.0077 0.0335 0.0633
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0046 0.0148 0.0274
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0775 0.4447 0.854
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.016 0.0311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0085 0.0382 0.0724
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0134 0.2174
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.039 0.0774
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0025 0.0038
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0024 0.0022 0.0017
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0732 0.1825
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0134 0.0269
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0021 0.0029
Treponema pallidum sodium- and chloride- dependent transporter 0.047 0.265 1
Schistosoma mansoni adenoreceptor 0.0048 0.016 0.0311
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0653 0.1244
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0287 0.0281
Brugia malayi Sodium:neurotransmitter symporter family protein 0.047 0.265 0.5084
Onchocerca volvulus 0.0048 0.016 0.0511
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0646
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.008 0.0349 0.069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0148 0.0287
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0024 0.0022 0.0054
Brugia malayi MH1 domain containing protein 0.0026 0.0029 0.0045
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus multilocularis musashi 0.0033 0.007 0.0065
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0046 0.0148 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0148 0.0274
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Toxoplasma gondii ABC1 family protein 0.0036 0.0091 0.1465
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0286 0.1564 0.1559
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0287 0.0613
Onchocerca volvulus 0.0032 0.0066 0.0198
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0329 0.0323
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0215 0.0403
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Echinococcus multilocularis tar DNA binding protein 0.0281 0.1534 0.1529
Brugia malayi Cytochrome P450 family protein 0.0034 0.0077 0.0137
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0096 0.0181
Schistosoma mansoni biogenic amine receptor 0.0048 0.016 0.0311
Brugia malayi latrophilin 2 splice variant baaae 0.0618 0.3521 0.6758
Trypanosoma brucei unspecified product 0.0028 0.0044 0.0065
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0058 0.0222 0.0434
Loa Loa (eye worm) hypothetical protein 0.0058 0.0222 0.0415
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0048 0.016 0.0298
Trypanosoma brucei unspecified product 0.0065 0.0261 0.0555
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0079 0.0345 0.0847
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0091 0.017
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0349 0.069
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.0653 0.1301
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.016 0.0298
Mycobacterium ulcerans hypothetical protein 0.0192 0.1011 0.2555
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0038 0.0104 0.0198
Brugia malayi hypothetical protein 0.0028 0.0044 0.0074
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0091 0.0176
Treponema pallidum licC protein (licC) 0.0125 0.0618 0.2302
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.016 0.0311
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0049 0.0166 0.037
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Trypanosoma brucei trypanothione reductase 0.0057 0.0215 0.0451
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0148 0.0143
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0349 0.0752
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0218 0.0427
Onchocerca volvulus Chorion peroxidase homolog 0.0032 0.0066 0.0198
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0042 0.0124 0.0118
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0349 0.069
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0349 0.069
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0215 0.4499
Brugia malayi Serotonin receptor 0.0048 0.016 0.0298
Brugia malayi MH2 domain containing protein 0.0026 0.0029 0.0045
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0308 0.0661
Brugia malayi Cytochrome P450 family protein 0.0023 0.0015 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.016 0.0311
Echinococcus multilocularis serotonin receptor 0.0299 0.1641 0.1637
Loa Loa (eye worm) inositol-1 0.0037 0.0096 0.0174
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0046 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Schistosoma mansoni thyroid hormone receptor 0.0198 0.1045 0.209
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0112 0.1783
Echinococcus granulosus uncharacterized sodium dependent transporter 0.008 0.0349 0.069
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0096 0.019
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0896 0.1988
Loa Loa (eye worm) MH2 domain-containing protein 0.0375 0.2091 0.401
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Brugia malayi Dopamine receptor protein 2 0.0048 0.016 0.0298
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0178 0.0928 0.1854
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0021 0.0029
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0119 0.0555
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.008 0.0349 0.7759
Brugia malayi larval opioid receptor 0.0048 0.016 0.0298
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0896 0.1988
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0269 0.0529
Brugia malayi glutaminase DH11.1 0.0317 0.1747 0.3348
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0349 0.069
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0046 0.0148 0.0274
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0067 0.0134
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.0583 0.1161
Echinococcus multilocularis dro:myosuppressin receptor 0.0048 0.016 0.0155
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0165 0.085 0.1699
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0269 0.0263
Echinococcus multilocularis carboxylesterase 5A 0.0082 0.0361 0.0356
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0896 0.1988
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.007 0.0124
Loa Loa (eye worm) hypothetical protein 0.0299 0.1641 0.3145
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0039 0.0033
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0035 0.0082 0.0154
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis G protein coupled receptor 139 0.0048 0.016 0.0155
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0148 0.0287
Trichomonas vaginalis aldehyde oxidase, putative 0.0168 0.0869 0.2704
Brugia malayi mbt repeat family protein 0.0058 0.0218 0.0408
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0091 0.0176
Echinococcus granulosus dna polymerase eta 0.0072 0.03 0.0592
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0096 0.1626
Echinococcus multilocularis neuropeptide receptor A26 0.0048 0.016 0.0155
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.016 0.0311
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0287 0.0541
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.016 0.0298
Loa Loa (eye worm) ThiF family protein 0.0038 0.0104 0.019
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0361 0.0356
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Brugia malayi beta-lactamase family protein 0.0036 0.0091 0.0163
Brugia malayi Cytochrome P450 family protein 0.0023 0.0015 0.0018
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0311
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Brugia malayi ThiF family protein 0.0038 0.0104 0.019
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0134 0.0129
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0218 0.0408
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0349 0.069
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Brugia malayi polk-prov protein 0.0045 0.0142 0.0263
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0048 0.016 0.0155
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0101 0.0193
Echinococcus multilocularis neuropeptide receptor 0.0048 0.016 0.0155
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0042 0.0124 0.2005
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0589 0.1294
Echinococcus multilocularis GPCR, family 2 0.0286 0.1564 0.1559
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Brugia malayi nuclear receptor NHR-88 0.0046 0.0148 0.0274
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) carboxylesterase 0.0082 0.0361 0.0684
Echinococcus granulosus hypothetical protein 0.0048 0.016 0.0311
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.016 0.0298
Onchocerca volvulus 0.0048 0.016 0.0511
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.033 0.1828 0.3663
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0091 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.1828 0.3663
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0088 0.1415
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0148 0.0274
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0015 0.0018
Onchocerca volvulus 0.0048 0.016 0.0511
Plasmodium falciparum amino acid transporter, putative 0.008 0.0349 0.8015
Onchocerca volvulus 0.0525 0.2978 0.9817
Onchocerca volvulus Peroxidasin homolog 0.0032 0.0066 0.0198
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0091 0.0193
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis serotonin transporter 0.047 0.265 0.2646
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0096 0.0151
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0096 0.1361
Brugia malayi intermediate filament protein 0.0033 0.007 0.0124
Loa Loa (eye worm) hypothetical protein 0.0066 0.0265 0.0499
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.016 0.0311
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.03 0.0567
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) transcription factor SMAD2 0.0375 0.2091 0.401
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.5641
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni RAR-like nuclear receptor 0.0046 0.0148 0.0287
Echinococcus granulosus ecdysone induced protein 78C 0.0046 0.0148 0.0287
Brugia malayi Muscleblind-like protein 0.0149 0.0759 0.1448
Echinococcus granulosus tachykinin peptides receptor 99D 0.0048 0.016 0.0311
Echinococcus granulosus neuropeptide receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0396 0.2213 0.4245
Brugia malayi Melatonin receptor type 1A 0.0048 0.016 0.0298
Brugia malayi Calcitonin receptor-like protein seb-1 0.0903 0.5207 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0073 0.0308 0.0764
Plasmodium falciparum transporter, putative 0.008 0.0349 0.8015
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0091 0.0085
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0684 0.3914 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0096 0.1361
Loa Loa (eye worm) steroid hormone receptor 0.0046 0.0148 0.0274
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0653 1
Echinococcus granulosus Smad4 0.0026 0.0029 0.0047
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.016 0.0298
Schistosoma mansoni opsin-like receptor 0.0048 0.016 0.0311
Brugia malayi Inositol-1 0.0037 0.0096 0.0174
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0424 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0101 0.0193
Mycobacterium ulcerans hypothetical protein 0.0024 0.0022 0.0017
Loa Loa (eye worm) RNA binding protein 0.0281 0.1534 0.2939
Loa Loa (eye worm) blistered cuticle protein 3 0.0032 0.0066 0.0115
Echinococcus granulosus orexin receptor type 2 0.0048 0.016 0.0311
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.016 0.0311
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0058 0.0222 0.0434
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0287 0.0697
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.008 0.0349 0.069
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.016 0.0298
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0044 0.0065
Brugia malayi Latrophilin receptor protein 2 0.0286 0.1564 0.2997
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.133
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0215 0.021
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0048 0.016 0.0511
Schistosoma mansoni biogenic amine receptor 0.0048 0.016 0.0311
Echinococcus granulosus peptide allatostatin:somatostatin 0.0048 0.016 0.0311
Leishmania major DNA polymerase kappa, putative 0.0049 0.0166 0.034
Schistosoma mansoni ap endonuclease 0.0037 0.0096 0.0181
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0046 0.0148 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0091 0.0171
Onchocerca volvulus 0.0032 0.0066 0.0198
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0096 0.0148
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus histone lysine methyltransferase setb 0.0087 0.039 0.0774
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0287 0.0681
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0142 0.0287
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Schistosoma mansoni hypothetical protein 0.0358 0.1988 0.3985
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0168 0.0869 0.2704
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0096 0.0029
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.016 0.0311
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0178 0.0928 0.0922
Onchocerca volvulus 0.0048 0.016 0.0511
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0589 0.1173
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.016 0.0298
Trichomonas vaginalis bromodomain-containing protein, putative 0.0054 0.0199 0.0385
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0035 0.0082 0.0077
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0035 0.0082 0.0077
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) beta-lactamase 0.0036 0.0091 0.0163
Schistosoma mansoni sodium-dependent amino acid transporter 0.008 0.0349 0.069
Schistosoma mansoni lipoxygenase 0.0084 0.0371 0.0734
Onchocerca volvulus 0.0535 0.3033 1
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0093 0.0424 0.0805
Echinococcus granulosus acetylcholinesterase 0.0082 0.0361 0.0715
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0684 0.3914 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0091 0.0193
Onchocerca volvulus 0.0036 0.0091 0.028
Echinococcus multilocularis g-protein coupled receptor 0.0048 0.016 0.0155
Onchocerca volvulus Neuropeptide F receptor homolog 0.0048 0.016 0.0511
Echinococcus granulosus smad 0.0026 0.0029 0.0047
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0038 0.0104 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0046 0.0148 0.0274
Onchocerca volvulus 0.0048 0.016 0.0511
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0157 0.8895
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0269 0.4349
Echinococcus multilocularis bloom syndrome protein 0.005 0.0172 0.0166
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0053 0.019 0.0371
Brugia malayi TAR-binding protein 0.0281 0.1534 0.2939
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Schistosoma mansoni biogenic amine (5HT) receptor 0.0299 0.1641 0.3289
Loa Loa (eye worm) solute carrier family 6 member 4 0.047 0.265 0.5084
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0882 0.1761
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0044 0.0713
Toxoplasma gondii hypothetical protein 0.0058 0.0222 0.3585
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0647 0.1605
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0265 0.0522
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.016 0.0311
Brugia malayi Dopamine receptor protein 1 0.0048 0.016 0.0298
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0091 0.0193
Echinococcus granulosus muscleblind protein 0.0149 0.0759 0.1514
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.0361 0.0715
Schistosoma mansoni lamin 0.0033 0.007 0.013
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0048 0.016 0.0155
Onchocerca volvulus 0.0036 0.0091 0.028
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0042 0.0124 0.0238
Mycobacterium ulcerans endonuclease IV 0.0093 0.0424 0.1049
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0265 0.0499
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0732 0.1825
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Brugia malayi Bromodomain containing protein 0.0051 0.0176 0.0328
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.016 0.0298
Schistosoma mansoni Smad4 0.0026 0.0029 0.0047
Schistosoma mansoni hypothetical protein 0.0077 0.0335 0.0662
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Brugia malayi GnHR receptor homolog 0.0048 0.016 0.0298
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) runx1 0.0067 0.0274 0.0516
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0589 0.1471
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0349 0.0752
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0032 0.0067 0.0117
Loa Loa (eye worm) hypothetical protein 0.0056 0.0207 0.0388
Brugia malayi beta-lactamase 0.0036 0.0091 0.0163
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0048 0.016 0.0311
Schistosoma mansoni zinc finger protein 0.0028 0.0043 0.0075
Brugia malayi Pre-SET motif family protein 0.0462 0.2602 0.4991
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0215 0.0421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0046 0.0148 0.0274
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0462 0.2602 0.4991
Schistosoma mansoni inositol monophosphatase 0.0037 0.0096 0.0182
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni lipoxygenase 0.0119 0.0583 0.1161
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.016 0.0155
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0535 0.3033 0.5821
Schistosoma mansoni amine GPCR 0.0448 0.252 0.5055
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0265 0.0522
Brugia malayi hypothetical protein 0.0032 0.0066 0.0115
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0088 0.1142
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0091 0.0163
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0119 0.0249
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0349 0.0343
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus granulosus dna polymerase kappa 0.0073 0.0308 0.0608
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0349 0.0689
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0287 0.0697
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.008 0.0349 0.069
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.016 0.0311
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Echinococcus granulosus GPCR family 2 0.0286 0.1564 0.3134
Onchocerca volvulus 0.0048 0.016 0.0511
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0091 0.0163
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0049 0.0794
Brugia malayi neuropeptide F receptor 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.0653 0.2431
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0112 0.0204
Schistosoma mansoni hypothetical protein 0.0025 0.0025 0.0039
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0096 0.0182
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.016 0.0298
Onchocerca volvulus 0.0033 0.007 0.0214
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0091 0.0171
Brugia malayi hypothetical protein 0.0036 0.0089 0.0161
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.016 0.0155
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0091 0.017
Schistosoma mansoni hypothetical protein 0.0618 0.3521 0.7068
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0046 0.0148 0.0143
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0038 0.0104 0.1583
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.016 0.0311
Schistosoma mansoni smad1 5 8 and 0.0026 0.0029 0.0047
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.0308 0.0752
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0647 0.1605
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0093 0.0424 0.1034
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Echinococcus granulosus acetylcholinesterase 0.0082 0.0361 0.0715
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.0583 0.0578
Onchocerca volvulus Peroxidasin homolog 0.0032 0.0066 0.0198
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0096 0.0322
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0335 0.0662
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0349 0.069
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0046 0.0148 0.0143
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0029 0.0023
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0119 0.0228
Brugia malayi Carboxylesterase family protein 0.0082 0.0361 0.0684
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0218 0.0213
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.016 0.0298
Brugia malayi hypothetical protein 0.0036 0.0089 0.0161
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.016 0.0155
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0091 0.0011
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0589 0.1457
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0157 0.1224
Echinococcus multilocularis muscleblind protein 0.0149 0.0759 0.0754
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0349 0.0752
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0091 0.0176
Schistosoma mansoni blooms syndrome DNA helicase 0.0032 0.0068 0.0124
Mycobacterium ulcerans beta-lactamase 0.0036 0.0091 0.0193
Echinococcus multilocularis fmrfamide receptor 0.0048 0.016 0.0155
Onchocerca volvulus 0.0048 0.016 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0046 0.0148 0.0274
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0181 0.0374
Trichomonas vaginalis DNA polymerase eta, putative 0.0073 0.0308 0.0764
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Echinococcus multilocularis neuropeptide FF receptor 2 0.0048 0.016 0.0155
Echinococcus granulosus allatostatin A receptor 0.0048 0.016 0.0311
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0039 0.0067
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.033 0.1828 0.3503
Loa Loa (eye worm) serotonin transporter b 0.047 0.265 0.5084
Loa Loa (eye worm) MBCTL1 0.0066 0.0265 0.0499
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0035 0.0082 0.0154
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0259 0.0488
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0775 0.4447 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0647 0.1605
Mycobacterium ulcerans hypothetical protein 0.0027 0.0039 0.0062
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0046 0.0148 0.0287
Leishmania major hypothetical protein, conserved 0.0036 0.0091 0.017
Echinococcus granulosus serotonin transporter 0.047 0.265 0.5317
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0181 0.0374
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0021 0.0015
Trypanosoma brucei C-8 sterol isomerase, putative 0.0775 0.4447 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0247 0.0523
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0093 0.0424 0.1034
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.016 0.0311
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0021 0.0031
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0029 0.0047
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.016 0.0311
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0119 0.0228
Brugia malayi PHD-finger family protein 0.0034 0.0081 0.0145
Toxoplasma gondii exonuclease III APE 0.0037 0.0096 0.155
Onchocerca volvulus 0.0058 0.0218 0.0702
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0112 0.0106
Brugia malayi MH2 domain containing protein 0.0026 0.0029 0.0045
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Serotonin receptor 0.0048 0.016 0.0298
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0125 0.0618 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0155
Echinococcus multilocularis neuropeptide receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.047 0.265 0.5084
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.033 0.1828 0.3663
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.0653 0.162
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0157 0.296
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0046 0.0148 0.0287
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0044 0.0065
Schistosoma mansoni peroxidasin 0.0032 0.0066 0.012
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1011 0.2542
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0775 0.4447 0.854
Trichomonas vaginalis esterase, putative 0.0036 0.0091 0.0011
Loa Loa (eye worm) acetylcholinesterase 1 0.0082 0.0361 0.0684
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Onchocerca volvulus 0.0048 0.016 0.0511
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0046 0.0148 0.0274
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Brugia malayi RE15519p 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0124
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.016 0.0155
Brugia malayi 6-phosphofructokinase 0.0131 0.0653 0.1244
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.016 0.0155
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0047 0.0153 0.2865
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0148 0.0143
Brugia malayi ORL1-like opioid receptor 0.0048 0.016 0.0298
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0046 0.0148 0.0287
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0653 0.1301
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0166 0.034
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0286 0.1564 0.1559
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0091 0.0176
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0091 0.0176
Loa Loa (eye worm) hypothetical protein 0.047 0.265 0.5084
Onchocerca volvulus 0.0066 0.0269 0.087
Schistosoma mansoni lamin 0.0033 0.007 0.013
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0096 0.003
Leishmania major C-8 sterol isomerase-like protein 0.0775 0.4447 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0653 0.1244
Schistosoma mansoni biogenic amine receptor 0.0048 0.016 0.0311
Brugia malayi Steroid receptor seven-up type 2 0.0046 0.0148 0.0274
Loa Loa (eye worm) hypothetical protein 0.0082 0.0361 0.0684
Echinococcus granulosus 7tm_1 domain containing protein 0.0048 0.016 0.0311
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0775 0.1547
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.1828 0.3663
Schistosoma mansoni sodium/chloride dependent transporter 0.047 0.265 0.5317
Mycobacterium leprae Probable lipase LipE 0.0036 0.0091 0.0176
Brugia malayi putative neuropeptide receptor 0.0048 0.016 0.0298
Echinococcus multilocularis peroxidasin 0.0032 0.0066 0.006
Echinococcus granulosus lamin dm0 0.0033 0.007 0.013
Schistosoma mansoni hypothetical protein 0.004 0.0112 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0046 0.0148 0.0274
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0176
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.0653 0.162
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0589 0.1471
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.016 0.0311
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Echinococcus multilocularis ecdysone induced protein 78C 0.0046 0.0148 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0046 0.0148 0.0274
Echinococcus multilocularis dna polymerase kappa 0.0073 0.0308 0.0303
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0048 0.016 0.0155
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0096 0.1554
Echinococcus granulosus g protein coupled receptor 0.0048 0.016 0.0311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0147
Brugia malayi RNA recognition motif domain containing protein 0.0281 0.1534 0.2939
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0149 0.0759 0.1448
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Onchocerca volvulus 0.047 0.265 0.8734
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0054 0.0199 0.3215
Mycobacterium tuberculosis Conserved hypothetical protein 0.0125 0.0618 0.1532
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0112 0.0204
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Plasmodium falciparum thioredoxin reductase 0.0057 0.0215 0.4499
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Echinococcus granulosus neuropeptide FF receptor 2 0.0048 0.016 0.0311
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0057 0.0213 0.049
Mycobacterium tuberculosis Conserved hypothetical protein 0.0125 0.0618 0.1532
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.203 0.4545
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0096 0.0182
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.0199 0.0388
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0329 0.065
Echinococcus multilocularis zinc finger protein 0.0028 0.0043 0.0037
Echinococcus granulosus serotonin receptor 0.0048 0.016 0.0311
Echinococcus granulosus FTZ F1 alpha 0.0046 0.0148 0.0287
Loa Loa (eye worm) translation initiation factor 4E 0.0042 0.0124 0.0227
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Treponema pallidum hypothetical protein 0.0027 0.0039 0.0108
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.016 0.0311
Onchocerca volvulus Peroxidase homolog 0.0032 0.0066 0.0198
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0042 0.0124 0.0238
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0088 0.029
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0029 0.0023
Brugia malayi Peroxidasin 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Bromodomain containing protein 0.0095 0.0438 0.0831
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.033 0.1828 0.1823
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0039 0.0067
Echinococcus granulosus somatostatin receptor 0.0048 0.016 0.0311
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0079 0.0345 0.0847
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.0073 0.013
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.203 0.4545
Schistosoma mansoni lozenge 0.0067 0.0274 0.054
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.0653 0.1438
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0684 0.3914 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0424 0.0805
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0046 0.0148 0.0287
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0073 0.0132
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0046 0.0148 0.0274
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0148 0.0274
Echinococcus granulosus sex peptide receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.033 0.1828 0.3503
Onchocerca volvulus 0.0048 0.016 0.0511
Mycobacterium ulcerans hypothetical protein 0.0125 0.0618 0.1547
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0111 0.0535 0.1332
Brugia malayi mbt repeat family protein 0.0058 0.0218 0.0408
Schistosoma mansoni myosin xvIII 0.0048 0.016 0.0311
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0054 0.0199 0.0385
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Onchocerca volvulus Dual oxidase homolog 0.0032 0.0066 0.0198
Toxoplasma gondii endonuclease IV APN 0.0093 0.0424 0.6861
Onchocerca volvulus 0.0048 0.016 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0148 0.0274
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.5641
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0589 0.0584
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.016 0.0155
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0112 0.0204
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.0147
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Plasmodium vivax ubiquitin activating enzyme, putative 0.0058 0.0222 0.4671
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0775 0.077
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0265 0.026
Brugia malayi beta-lactamase family protein 0.0036 0.0091 0.0163
Echinococcus granulosus lamin 0.0033 0.007 0.013
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0732 0.1825
Onchocerca volvulus 0.0048 0.016 0.0511
Mycobacterium ulcerans hypothetical protein 0.0125 0.0618 0.1547
Loa Loa (eye worm) hypothetical protein 0.0903 0.5207 1
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Onchocerca volvulus Peroxidase homolog 0.0032 0.0066 0.0198
Echinococcus multilocularis g protein coupled receptor 0.0048 0.016 0.0155
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0096 0.0182
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0349 0.069
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0218 0.0427
Loa Loa (eye worm) latrophilin receptor protein 2 0.0286 0.1564 0.2997
Echinococcus multilocularis orexin receptor type 2 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0074
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0038 0.0104 0.0201
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.016 0.0311
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0057 0.0213 0.0507
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.047 0.265 0.5317
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0046 0.0148 0.0287
Trichomonas vaginalis glutaminase, putative 0.0317 0.1747 0.5742
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0029 0.0046
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0048 0.016 0.0155
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Leishmania major DNA polymerase eta, putative 0.0043 0.0134 0.0269
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Echinococcus granulosus zinc finger protein 0.0028 0.0043 0.0075
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0653 0.1438
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0215 0.0451
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.016 0.0298
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0125 0.0618 0.1547
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0088 0.0629
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0088 0.1415
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0053 0.0236
Loa Loa (eye worm) hypothetical protein 0.0299 0.1641 0.3145
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0048 0.016 0.0311
Echinococcus multilocularis dna polymerase eta 0.0072 0.03 0.0295
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0024 0.0022 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0148 0.0274
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0287 0.0566
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Mycobacterium ulcerans lipase LipD 0.0036 0.0091 0.0193
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0286 0.1564 0.3134
Echinococcus granulosus dro:myosuppressin receptor 0.0048 0.016 0.0311
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0653 1
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0684 0.3914 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.016 0.0298
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0029 0.0045
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0096 0.003
Loa Loa (eye worm) hypothetical protein 0.047 0.265 0.5084
Brugia malayi MH1 domain containing protein 0.0026 0.0029 0.0045
Schistosoma mansoni bromodomain containing protein 0.0081 0.0354 0.0701
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0148 0.0287
Echinococcus multilocularis smad 0.0026 0.0029 0.0023
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis FTZ F1 alpha 0.0046 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0096 0.009
Loa Loa (eye worm) hypothetical protein 0.004 0.0112 0.0204
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Echinococcus granulosus g protein coupled receptor 0.0048 0.016 0.0311
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0096 0.0207
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0088 0.1142
Brugia malayi Bloom's syndrome protein homolog 0.005 0.0172 0.0319
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0589 0.1471
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0021 0.0029
Schistosoma mansoni retinoic acid receptor RXR 0.0165 0.085 0.1699
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Brugia malayi Blistered cuticle protein 3 0.0032 0.0066 0.0115
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0048 0.016 0.0311
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0261 0.0555
Leishmania major eukaryotic translation initiation factor-like 0.0042 0.0124 0.0245
Brugia malayi G-protein coupled receptor 0.0048 0.016 0.0298
Plasmodium vivax amine transporter, putative 0.008 0.0349 0.8015
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0038 0.0104 0.0099
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0112 0.1783
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0335 0.0329
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0088 0.1142
Echinococcus granulosus neuropeptide receptor A26 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.016 0.0298
Echinococcus multilocularis neuropeptide s receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0046 0.0152 0.0281
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0091 0.0176
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0042 0.0124 0.0245
Schistosoma mansoni glutaminase 0.0317 0.1747 0.3501
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0653 0.1301
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Loa Loa (eye worm) hypothetical protein 0.0535 0.3033 0.5821
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.5641
Brugia malayi nuclear receptor RXR 0.0024 0.0021 0.0029
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0311
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Loa Loa (eye worm) TAR-binding protein 0.0281 0.1534 0.2939
Entamoeba histolytica recQ family helicase, putative 0.0038 0.0101 0.0234
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0058 0.0222 0.0216
Trichomonas vaginalis DNA helicase recq, putative 0.005 0.0172 0.0291
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Brugia malayi MH2 domain containing protein 0.0375 0.2091 0.401
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Echinococcus granulosus geminin 0.0865 0.4979 1
Schistosoma mansoni thyroid hormone receptor 0.0198 0.1045 0.209
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0046 0.0148 0.0287
Mycobacterium ulcerans epimerase 0.0024 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0049 0.0166 0.034
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0335 0.0662
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.016 0.0298
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0148 0.0287
Onchocerca volvulus 0.008 0.0349 0.1133
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0119 0.0218
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0091 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0046 0.0148 0.0274
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0349 0.0659
Brugia malayi follicle stimulating hormone receptor 0.0048 0.016 0.0298
Brugia malayi translation initiation factor 4E 0.0042 0.0124 0.0227
Brugia malayi nuclear hormone receptor 0.0046 0.0148 0.0274
Brugia malayi RNA binding protein 0.0281 0.1534 0.2939
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0038 0.0104 0.0198
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0044 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Echinococcus granulosus carboxylesterase 5A 0.0082 0.0361 0.0715
Loa Loa (eye worm) intermediate filament protein 0.0033 0.007 0.0124
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus multilocularis Smad4 0.0026 0.0029 0.0023
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Loa Loa (eye worm) glutaminase 0.0317 0.1747 0.3348
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.1234 0.3115
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0647 0.1605
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0286 0.1564 0.3134
Loa Loa (eye worm) hypothetical protein 0.0618 0.3521 0.6758
Leishmania major eukaryotic translation initiation factor-like protein 0.0042 0.0124 0.0245
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0046 0.0148 0.0287
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0042 0.0124 0.0245
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.016 0.0311
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.016 0.0311
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0048 0.016 0.0155
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0218 0.0427
Schistosoma mansoni hypothetical protein 0.0152 0.0775 0.1547
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0151 0.0145
Echinococcus multilocularis thyroid hormone receptor alpha 0.0198 0.1045 0.104
Schistosoma mansoni DNA helicase recq1 0.0035 0.0082 0.0154
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0349 0.069
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0054 0.0199 0.3215
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0589 0.1173
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0653 1
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.03 0.0643
Loa Loa (eye worm) RecQ helicase 0.005 0.0172 0.0319
Onchocerca volvulus 0.008 0.0349 0.1133
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0021 0.0031
Plasmodium falciparum glutathione reductase 0.0057 0.0215 0.4499
Toxoplasma gondii hypothetical protein 0.0059 0.0225 0.3643
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0035 0.0082 0.1003
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0218 0.0427
Plasmodium vivax SET domain protein, putative 0.0066 0.0269 0.5914
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0349 0.0689
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.0147
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0151 0.0291
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0308 0.0661
Brugia malayi Thioredoxin reductase 0.0057 0.0215 0.0403
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.016 0.0311
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0349 0.0659
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0646
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0168 0.0869 0.2704
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.0199 0.4069
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0096 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Trypanosoma brucei unspecified product 0.0028 0.0044 0.0065
Schistosoma mansoni DNA polymerase eta 0.0072 0.03 0.0592
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.016 0.0298
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0101 0.0193
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0647 0.1605
Echinococcus granulosus fmrfamide receptor 0.0048 0.016 0.0311
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0653 0.1438
Echinococcus granulosus uncharacterized sodium dependent transporter 0.008 0.0349 0.069
Schistosoma mansoni opsin-like receptor 0.0048 0.016 0.0311
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0091 0.017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.033 0.1828 0.1823
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0265 0.0522
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0046 0.0148 0.0471
Echinococcus multilocularis g protein coupled receptor 0.0048 0.016 0.0155
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0148 0.0274
Brugia malayi ecdysteroid receptor 0.0046 0.0148 0.0274
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0087 0.039 0.0385
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0096 0.009
Plasmodium vivax glutathione reductase, putative 0.0057 0.0215 0.4499
Leishmania major DNA polymerase eta, putative 0.0072 0.03 0.0643
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0234 0.1261 0.1256
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0096 0.0173
Loa Loa (eye worm) hypothetical protein 0.0032 0.0067 0.0118
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Leishmania major ubiquitin-activating enzyme-like protein 0.0038 0.0104 0.0201
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0141 0.0708 0.0703
Loa Loa (eye worm) hypothetical protein 0.0087 0.039 0.074
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0035 0.0082 0.0147
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0287 0.0566
Schistosoma mansoni histamine h1 receptor 0.0048 0.016 0.0311
Brugia malayi hypothetical protein 0.008 0.0349 0.066
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0067 0.0134
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0073 0.0132
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0181 0.0374
Loa Loa (eye worm) hypothetical protein 0.0058 0.0218 0.0408
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.03 0.0643
Echinococcus multilocularis Protein lozenge 0.0067 0.0274 0.0269
Brugia malayi hypothetical protein 0.0024 0.0021 0.0029
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.016 0.0155
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.133
Schistosoma mansoni hypothetical protein 0.0865 0.4979 1
Echinococcus multilocularis g protein coupled receptor 0.0048 0.016 0.0155
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0424 1
Schistosoma mansoni smad1 5 8 and 0.0026 0.0029 0.0047
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0091 0.0176
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0038 0.0104 0.1583
Loa Loa (eye worm) Smad1 0.0026 0.0029 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0091 0.0171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.1828 0.3663
Loa Loa (eye worm) phosphofructokinase 0.0131 0.0653 0.1244
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0091 0.0171
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.0653 0.0647
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0759 0.0754
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.0653 0.1635
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0046 0.0148 0.0274
Loa Loa (eye worm) hypothetical protein 0.0072 0.03 0.0567
Echinococcus granulosus intermediate filament protein 0.0033 0.007 0.013
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0011
Onchocerca volvulus 0.0046 0.0148 0.0471
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0127
Onchocerca volvulus Protein ultraspiracle homolog 0.0046 0.0148 0.0471
Giardia lamblia DINP protein human, muc B family 0.0049 0.0166 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0096 0.0182
Brugia malayi glutathione reductase 0.0057 0.0215 0.0403
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.016 0.0298
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0029 0.0047
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0096 0.003
Brugia malayi 6-phosphofructokinase 0.0131 0.0653 0.1244
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0155
Echinococcus granulosus peroxidasin 0.0032 0.0066 0.012
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0096 0.0029
Trichomonas vaginalis set domain proteins, putative 0.0525 0.2978 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0029 0.0047
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.016 0.0298
Trichomonas vaginalis DNA helicase recq, putative 0.0038 0.0101 0.0046
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0119 0.0113
Echinococcus multilocularis somatostatin receptor 0.0048 0.016 0.0155
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0042 0.0124 0.0245
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.0308 0.0752
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0042 0.0124 0.0245
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.203 0.4545
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.008 0.0349 0.069
Toxoplasma gondii ThiF family protein 0.0038 0.0104 0.1686
Brugia malayi G-protein coupled receptor 0.0048 0.016 0.0298
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0903 0.5207 1
Mycobacterium ulcerans glutaminase 0.0317 0.1747 0.4442
Schistosoma mansoni ap endonuclease 0.0037 0.0096 0.0181
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0349 0.0752
Echinococcus granulosus alpha 1A adrenergic receptor 0.0048 0.016 0.0311
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.005 0.0172 0.0402
Loa Loa (eye worm) hypothetical protein 0.0286 0.1564 0.2997
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0091 0.1223
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0119 0.0218
Schistosoma mansoni coup transcription factor 0.0046 0.0148 0.0287
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0096 0.0182
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0218 0.0213
Brugia malayi ThiF family protein 0.0058 0.0222 0.0415
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0265 0.026
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0048 0.016 0.0155
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0088 0.1415
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0011
Echinococcus granulosus 7TM GPCR rhodopsin 0.0048 0.016 0.0311
Toxoplasma gondii hypothetical protein 0.008 0.0349 0.5641
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0079 0.0345 0.0831
Loa Loa (eye worm) acetyltransferase 0.0178 0.0928 0.1773
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0589 0.9523
Schistosoma mansoni peroxidasin 0.0032 0.0066 0.012
Brugia malayi AKH receptor 0.0048 0.016 0.0298
Echinococcus granulosus tar DNA binding protein 0.0281 0.1534 0.3073
Echinococcus granulosus biogenic amine 5HT receptor 0.0299 0.1641 0.3289
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0046 0.0148 0.0274
Toxoplasma gondii thioredoxin reductase 0.0057 0.0215 0.3479
Schistosoma mansoni intermediate filament proteins 0.0033 0.007 0.013
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0647 0.1605
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0096 0.0207
Echinococcus granulosus g protein coupled receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus multilocularis fmrfamide receptor 0.0048 0.016 0.0155
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0349 0.0343
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.203 0.4545
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0091 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0142 0.0287
Chlamydia trachomatis endonuclease IV 0.0093 0.0424 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0732 0.1825
Toxoplasma gondii hypothetical protein 0.008 0.0349 0.5641
Brugia malayi Dopamine receptor 0.0048 0.016 0.0298
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Activation of rat PXR expressed in human HepG2 cells up to 46 uM after 24 hrs by luciferase reporter gene based luminescent analysis ChEMBL. 20966043
Activity (binding) Induction of human myc epitope-tagged GLUT1 translocation to plasma membrane overexpressed in rat L6 cells at 2 mM after 30 mins by immunocolorimetric analysis in presence of 23.5 mM D-glucose ChEMBL. 23984871
Activity (binding) < 5 % Inhibition of human AchE-induced amyloid beta aggregation at 100 uM ChEMBL. 18181565
Activity (functional) = 5.2 % Antioxidant activity assessed as DPPH reducing activity at 0.5 mM after 20 mins ChEMBL. 17444626
Activity (functional) = 6.8 % Antioxidant activity assessed as DPPH reducing activity at 0.5 mM after 60 mins ChEMBL. 17444626
Activity (functional) = 19.2 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at S phase at 100 uM after 24 hrs by flow cytometry (Rvb = 21+/-0.9%) ChEMBL. 21111517
Activity (functional) = 19.3 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at S phase at 300 uM after 24 hrs by flow cytometry (Rvb = 21+/-0.9%) ChEMBL. 21111517
Activity (functional) = 20.1 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at S phase at 150 uM after 24 hrs by flow cytometry (Rvb = 21+/-0.9%) ChEMBL. 21111517
Activity (functional) = 20.3 % Antioxidant activity assessed as DPPH reducing activity at 0.1 mM after 20 mins ChEMBL. 17444626
Activity (functional) = 27.1 % Antioxidant activity assessed as DPPH reducing activity at 0.1 mM after 60 mins ChEMBL. 17444626
Activity (functional) = 32.1 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at G2/M phase at 150 uM after 24 hrs by flow cytometry (Rvb = 17.6+/-1%) ChEMBL. 21111517
Activity (functional) = 36.9 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at G2/M phase at 100 uM after 24 hrs by flow cytometry (Rvb = 17.6+/-1%) ChEMBL. 21111517
Activity (functional) = 37.5 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at G0/G1 phase at 300 uM after 24 hrs by flow cytometry (Rvb = 61.4+/-1.1%) ChEMBL. 21111517
Activity (functional) = 38.6 % Antioxidant activity assessed as DMSO hydroxyl radical scavenging activity at 0.1 mM ChEMBL. 17444626
Activity (functional) = 40.3 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at G2/M phase at 300 uM after 24 hrs by flow cytometry (Rvb = 17.6+/-1%) ChEMBL. 21111517
Activity (functional) = 43.5 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at G0/G1 phase at 100 uM after 24 hrs by flow cytometry (Rvb = 61.4+/-1.1%) ChEMBL. 21111517
Activity (functional) = 45.6 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at G0/G1 phase at 150 uM after 24 hrs by flow cytometry (Rvb = 61.4+/-1.1%) ChEMBL. 21111517
Activity (functional) = 58.5 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 50 uM ChEMBL. 15658850
Activity (functional) = 65 % Induction of apoptosis in human SMMC7721 cells at 5 mM after 96 hrs ChEMBL. 20403695
Activity (functional) = 74.33 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 10 uM ChEMBL. 15658850
Activity (functional) = 79.5 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 5 uM ChEMBL. 15658850
Activity (functional) = 83 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 1 uM ChEMBL. 15658850
Activity (functional) = 86 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 0 uM ChEMBL. 15658850
Activity (functional) = 90.25 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 0.5 uM ChEMBL. 15658850
Activity (functional) = 91.25 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 0.1 uM ChEMBL. 15658850
Arrhythmia score (functional) < 6.3 Effect on in vitro myocardial electrical activity (arrhythmia score) at 5 microM ChEMBL. 11708933
cLogP = 2.39 The compound was evaluated for lipophilicity. ChEMBL. 11708933
EC50 (ADMET) = 2.8 uM Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assay ChEMBL. 20966043
EC50 (functional) = 121.6 uM Ability of the compound for prevention of GSH depletion was measured in mouse ChEMBL. 12031315
EC50 (functional) = 250 uM Induction of apoptosis in human HT-29 cells ChEMBL. 20403695
Efficacy (ADMET) = 107.9 % Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assay relative to SR12813 ChEMBL. 20966043
GI (functional) = 0.14 % Cytotoxicity against human KB cells assessed as growth inhibition at 0.1 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 2.39 % Cytotoxicity against human NCI-H460 cells assessed as growth inhibition at 10 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 2.52 % Cytotoxicity against human Bel7402 cells assessed as growth inhibition at 1 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 4.65 % Cytotoxicity against human NCI-H460 cells assessed as growth inhibition at 1 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 4.77 % Cytotoxicity against human Bel7402 cells assessed as growth inhibition at 10 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 5.72 % Cytotoxicity against human NCI-H460 cells assessed as growth inhibition at 100 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 5.72 % Growth inhibition of Homo sapiens (human) NCI-H460 cells at 100 ug/ml by MTT assay ChEMBL. No reference
GI (functional) = 6.5 % Growth inhibition of human HT-29 cells at 100 uM after 48 hrs by BrdU-ELISA assay ChEMBL. 21111517
GI (functional) = 7.18 % Cytotoxicity against human KB cells assessed as growth inhibition at 10 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 8.17 % Cytotoxicity against human Bel7402 cells assessed as growth inhibition at 100 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 8.6 % Cytotoxicity against human KB cells assessed as growth inhibition at 1 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 8.71 % Cytotoxicity against human NCI-H460 cells assessed as growth inhibition at 0.1 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 10.96 % Cytotoxicity against human KB cells assessed as growth inhibition at 100 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 17.8 % Growth inhibition of human HT-29 cells at 100 uM after 24 hrs by BrdU-ELISA assay ChEMBL. 21111517
GI (functional) = 18.4 % Growth inhibition of human HT-29 cells at 150 uM after 48 hrs by BrdU-ELISA assay ChEMBL. 21111517
GI (functional) = 19.5 % Growth inhibition of human HT-29 cells at 300 uM after 48 hrs by BrdU-ELISA assay ChEMBL. 21111517
GI (functional) = 24 % Growth inhibition of human HT-29 cells at 300 uM after 24 hrs by BrdU-ELISA assay ChEMBL. 21111517
GI (functional) = 25.5 % Growth inhibition of human HT-29 cells at 150 uM after 24 hrs by BrdU-ELISA assay ChEMBL. 21111517
IC50 (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) Inhibition of bovine COX1 ChEMBL. 17976864
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
IC50 (binding) > 1 10'-3M Inhibition of human serum recombinant AChE after 20 mins using acetylthiocholine iodide as a substrate by Ellman's assay ChEMBL. 21924801
IC50 (binding) > 1 10'-3M Inhibition of human serum recombinant BChE after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assay ChEMBL. 21924801
IC50 (functional) > 0.4 mM Evaluated for the interaction with 0.2 mM of the stable free radical DPPH. ChEMBL. 11708933
IC50 (binding) = 1 nM Inhibition of human AchE ChEMBL. 18181565
IC50 (binding) > 1000000 nM Inhibitory concentration against human recombinant acetylcholinesterase ChEMBL. 15658850
IC50 (binding) > 1000000 nM Inhibitory concentration against human recombinant butyrylcholinesterase ChEMBL. 15658850
IC50 (binding) uM In vitro inhibition concentration of the compound was evaluated on the effect of conversion by Nitric Oxide synthase of [3H]-L-arginine into [3H]-L-citrulline; Not active up to 100 microM ChEMBL. 12031315
IC50 (binding) = 0 uM Inhibition of human COX2 ChEMBL. 17976864
IC50 (functional) = 19.6 uM Neuroprotective effect was measured by its ability to protect mouse hippocampal neuronal HT-22 cell lines from oxidative stress caused by glutamate ChEMBL. 12031315
IC50 (functional) = 54.86 uM Antioxidant activity against formation of ROS was determined in t-BuOOH treated LNCaP cells after 24 h of incubation with compounds (1-100 uM) ChEMBL. 15633998
IC50 (functional) > 100 uM Cytotoxicity against human MRC5 cells after 48 hrs by SRB assay ChEMBL. 25874330
IC50 (functional) > 1000 uM Inhibition of in vitro peroxidation (LP) of rat Hepatic microsomal membrane lipid ChEMBL. 11708933
Inhibition (binding) Inhibition of mushroom tyrosinase using L-DOPA as substrate at 2.5 mM preincubated for 10 to 15 mins prior to substrate addition by spectrophotometry ChEMBL. 24090916
Inhibition (functional) = 25.2 % Inhibition of nitrite level in LPS-induced mouse RAW264.7 cells at 5 uM by Griess assay relative to LPS treated control ChEMBL. 21183258
Inhibition (binding) = 29.1 % Inhibition of soybean lipoxygenase at 0.1 mM ChEMBL. 17444626
Inhibition (binding) = 29.1 % Inhibition of soybean lipoxygenase at 0.1 mM ChEMBL. 17444626
Inhibition (functional) = 29.6 % Inhibition of carrageenin-induced Fischer 344 rat paw edema at 0.01 mmol/kg, ip ChEMBL. 17444626
Inhibition (binding) < 30 % Inhibition of COX2 at 100 uM by scintillation proximity assay ChEMBL. 12444669
Inhibition (functional) = 50 % Growth inhibition of human FADU cells at 10 uM ChEMBL. 20403695
Inhibition (functional) = 50 % Growth inhibition of human SCC9 cells at 10 uM ChEMBL. 20403695
Inhibition (functional) = 50 % Growth inhibition of human SCC25 cells at 10 uM ChEMBL. 20403695
Inhibition (binding) = 76 % Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products at 500 uM preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method relative to control ChEMBL. 24088053
Inhibition (binding) = 95 % Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products at 500 uM preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method relative to control ChEMBL. 24088053
Inhibition (ADMET) = 103.3327209 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 129.0717504 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Kd (functional) > 5 Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoreceptor) ChEMBL. 15633998
Kd (functional) > 5 Blocking activity was assessed by antagonism of (-)-phenylephrine induced contraction of rat spleen (alpha1B adrenoreceptor) ChEMBL. 15633998
Kd (functional) > 5 Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (alpha1D adrenoreceptor) ChEMBL. 15633998
Ki (binding) DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
Log Ki (binding) Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]-prazosin to label cloned human alpha 1b expressed in CHO cells; Not tested ChEMBL. 15633998
Log Ki (binding) Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]-prazosin to label cloned human alpha 1a expressed in CHO cells; Not tested ChEMBL. 15633998
Log Ki (binding) Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]-prazosin to label cloned human alpha 1d expressed in CHO cells; Not tested ChEMBL. 15633998
MDA content (functional) < 1.03 uM (g of tissue)-1 Effect on in vitro accumulation of MDA content in heart, at conc of 5 microM ChEMBL. 11708933
MNCC (ADMET) = 0.1 mM Cytotoxicity against mouse B16F10 cells assessed as cell viability after 48 hrs by MTT assay ChEMBL. 24090916
Potency (functional) 0.2512 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV. (Class of assay: confirmatory) [Related pubchem assays: 1705, 1707 ] ChEMBL. No reference
Potency (functional) 0.8913 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.6109 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8024 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen)] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS Validation Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) = 33.8078 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Human Peripheral Myelin Protein 22 (PMP22) Expression/Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: Validation of Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.6858 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23
Homo sapiens ChEMBL23 12031315

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

39 literature references were collected for this gene.

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