Detailed information for compound 233111

Basic information

Technical information
  • TDR Targets ID: 233111
  • Name: 1,2-Dithiolane-3R-pentanoic acid
  • MW: 206.326 | Formula: C8H14O2S2
  • H donors: 1 H acceptors: 2 LogP: 1.68 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCCC[C@H]1SSCC1
  • InChi: 1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
  • InChiKey: AGBQKNBQESQNJD-SSDOTTSWSA-N  


Substructure search Similarity search

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Synonyms

  • 5-[(3R)-dithiolan-3-yl]pentanoic acid
  • Lipoate
  • Lipoic Acid
  • Thioctic acid
  • alpha-Lipoic acid
  • 5-[(3R)-3-dithiolanyl]pentanoic acid
  • 5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid
  • 5-[(3R)-dithiolan-3-yl]valeric acid
  • 1200-22-2
  • AIDS-003362
  • LPA
  • AIDS003362
  • Thioctanoic acid
  • (+)-alpha-Lipoic acid
  • (R)-(+)-lipoic acid
  • (R)-1,2-Dithiolane-3-pentanoic acid
  • (R)-lipoic acid
  • CHEBI:30314
  • Thioctic acid d-form
  • 1,2-Dithiolane-3-pentanoic acid, (R)-
  • R-Lipoate
  • .alpha.-Lipoic acid
  • 5-(1,2-Dithiolan-3-yl)valeric acid
  • 5-19-07-00237 (Beilstein Handbook Reference)
  • (R)-()-1,2-Dithiolane-3-pentanoic acid
  • 6,8-Thioctic acid
  • 6,8-Thiotic acid
  • 6-Thioctic acid
  • 6-Thiotic acid
  • Acetate-replacing factor
  • BRN 0122410
  • NCGC00094396-03
  • DRG-0236
  • EINECS 200-534-6
  • Heparlipon
  • Liposan
  • Lipothion
  • Protogen A
  • Pyruvate oxidation factor
  • Thioctacid
  • Thioctic acid [JAN]
  • Thioctidase
  • Thioctsan
  • Thioktsaeure [German]
  • Thiooctanoic acid
  • Tioctacid
  • Tioctidasi
  • Tioctidasi acetate replacing factor
  • alpha-Liponsaeure [German]
  • (R)-(+)-Lipoate
  • C16241
  • R-(+)-Lipoic acid
  • 579602_ALDRICH
  • Lopac0_001129
  • LMFA01130001
  • R-Lipoic acid
  • EU-0101129
  • STOCK1N-43250

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Alpha-1d adrenergic receptor Starlite/ChEMBL References
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Escherichia coli endonuclease IV with intrinsic 3'-5' exonuclease activity Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens acetylcholinesterase (Yt blood group) Starlite/ChEMBL References
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Rattus norvegicus Alpha-1a adrenergic receptor Starlite/ChEMBL References
Rattus norvegicus Alpha-1b adrenergic receptor Starlite/ChEMBL References
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Homo sapiens nuclear receptor subfamily 1, group I, member 2 Starlite/ChEMBL References
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_129467 All targets in OG5_129467
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129467 All targets in OG5_129467
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum endonuclease V, putative Get druggable targets OG5_129467 All targets in OG5_129467
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium yoelii AP endonuclease 1 Get druggable targets OG5_129467 All targets in OG5_129467
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis apurinic/apyrimidinic endonuclease Apn1 Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase Get druggable targets OG5_129467 All targets in OG5_129467
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Mycobacterium ulcerans endonuclease IV Get druggable targets OG5_129467 All targets in OG5_129467
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans apurinic/apyrimidinic endonuclease/3'-repair diesterase Get druggable targets OG5_129467 All targets in OG5_129467
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Alpha-1D adrenergic receptor, putative Get druggable targets OG5_128924 All targets in OG5_128924
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Chlamydia trachomatis endonuclease IV Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis apurinic endonuclease (APN1) family protein Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Get druggable targets OG5_128924 All targets in OG5_128924
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii endonuclease IV APN Get druggable targets OG5_129467 All targets in OG5_129467
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) Get druggable targets OG5_129467 All targets in OG5_129467
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum AP endonuclease of the TIM barrel fold, possible bacterial horizontal transfer Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni amine GPCR Get druggable targets OG5_128924 All targets in OG5_128924
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Echinococcus multilocularis neuropeptide Y receptor Alpha-1a adrenergic receptor   466 aa 419 aa 19.6 %
Echinococcus granulosus g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 399 aa 20.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Onchocerca volvulus Alpha-1b adrenergic receptor   515 aa 429 aa 20.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Alpha-1a adrenergic receptor   466 aa 443 aa 31.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Echinococcus granulosus rhodopsin orphan GPCR Alpha-1a adrenergic receptor   466 aa 418 aa 20.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Schistosoma japonicum FMRFamide receptor, putative Alpha-1a adrenergic receptor   466 aa 374 aa 19.5 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Echinococcus granulosus g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 414 aa 20.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Echinococcus multilocularis g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 414 aa 20.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Echinococcus granulosus biogenic amine 5HT receptor Alpha-1a adrenergic receptor   466 aa 418 aa 30.4 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Alpha-1a adrenergic receptor   466 aa 386 aa 31.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Brugia malayi ecdysteroid receptor nuclear receptor subfamily 1, group I, member 2 434 aa 427 aa 25.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Brugia malayi Carboxylesterase family protein acetylcholinesterase (Yt blood group) 614 aa 510 aa 26.5 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Echinococcus multilocularis g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 398 aa 21.4 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.0583 0.1161
Brugia malayi glutaminase DH11.1 0.0317 0.1747 0.3348
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.03 0.0643
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Echinococcus granulosus dna polymerase eta 0.0072 0.03 0.0592
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0096 0.003
Onchocerca volvulus 0.0048 0.016 0.0511
Brugia malayi RNA binding protein 0.0281 0.1534 0.2939
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0176
Echinococcus multilocularis GPCR, family 2 0.0286 0.1564 0.1559
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0119 0.0249
Schistosoma mansoni DNA helicase recq1 0.0035 0.0082 0.0154
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0048 0.016 0.0155
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.0308 0.0752
Leishmania major eukaryotic translation initiation factor-like protein 0.0042 0.0124 0.0245
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0125 0.0618 1
Brugia malayi putative neuropeptide receptor 0.0048 0.016 0.0298
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0091 0.0171
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.0361 0.0715
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0157 0.1224
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.016 0.0311
Schistosoma mansoni hypothetical protein 0.0865 0.4979 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0148 0.0274
Schistosoma mansoni RAR-like nuclear receptor 0.0046 0.0148 0.0287
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0096 0.0029
Leishmania major DNA polymerase kappa, putative 0.0049 0.0166 0.034
Brugia malayi G protein-coupled receptor 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0618 0.3521 0.6758
Schistosoma mansoni lipoxygenase 0.0119 0.0583 0.1161
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0168 0.0869 0.2704
Echinococcus multilocularis serotonin transporter 0.047 0.265 0.2646
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0349 0.0343
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0424 1
Plasmodium falciparum transporter, putative 0.008 0.0349 0.8015
Schistosoma mansoni retinoic acid receptor RXR 0.0165 0.085 0.1699
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0044 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0046 0.0148 0.0274
Schistosoma mansoni smad 0.0026 0.0029 0.0047
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0218 0.0427
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.016 0.0311
Schistosoma mansoni smad1 5 8 and 0.0026 0.0029 0.0047
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0269 0.0263
Plasmodium falciparum thioredoxin reductase 0.0057 0.0215 0.4499
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0148 0.0274
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis peroxidasin 0.0032 0.0066 0.006
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0091 0.0163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.033 0.1828 0.3663
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0088 0.1415
Brugia malayi Muscleblind-like protein 0.0149 0.0759 0.1448
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0088 0.1142
Schistosoma mansoni lipoxygenase 0.0084 0.0371 0.0734
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0091 0.0171
Echinococcus multilocularis neuropeptide receptor A26 0.0048 0.016 0.0155
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0091 0.0176
Schistosoma mansoni lamin 0.0033 0.007 0.013
Echinococcus multilocularis Smad4 0.0026 0.0029 0.0023
Loa Loa (eye worm) glutathione reductase 0.0057 0.0215 0.0403
Loa Loa (eye worm) hypothetical protein 0.047 0.265 0.5084
Onchocerca volvulus Dual oxidase homolog 0.0032 0.0066 0.0198
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0096 0.0001
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0759 0.0754
Loa Loa (eye worm) hypothetical protein 0.0085 0.0382 0.0724
Mycobacterium leprae Probable lipase LipE 0.0036 0.0091 0.0176
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Schistosoma mansoni steroid hormone receptor ad4bp 0.0046 0.0148 0.0287
Loa Loa (eye worm) hypothetical protein 0.0056 0.0207 0.0388
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0112 0.1783
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0029 0.0046
Onchocerca volvulus 0.0048 0.016 0.0511
Onchocerca volvulus 0.008 0.0349 0.1133
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.016 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0096 0.0148
Echinococcus granulosus neuropeptide receptor A26 0.0048 0.016 0.0311
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0021 0.0029
Mycobacterium ulcerans lipase LipD 0.0036 0.0091 0.0193
Echinococcus multilocularis g protein coupled receptor 0.0048 0.016 0.0155
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0091 0.0176
Onchocerca volvulus 0.0046 0.0148 0.0471
Schistosoma mansoni DNA polymerase eta 0.0072 0.03 0.0592
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0048 0.016 0.0311
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0176
Brugia malayi Thioredoxin reductase 0.0057 0.0215 0.0403
Echinococcus multilocularis G protein coupled receptor 139 0.0048 0.016 0.0155
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0024 0.0022 0.0031
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0134 0.0259
Brugia malayi polk-prov protein 0.0045 0.0142 0.0263
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0058 0.0222 0.0434
Echinococcus multilocularis sex peptide receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0903 0.5207 1
Schistosoma mansoni hypothetical protein 0.0358 0.1988 0.3985
Echinococcus multilocularis zinc finger protein 0.0028 0.0043 0.0037
Loa Loa (eye worm) Smad1 0.0026 0.0029 0.0045
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.016 0.0298
Trichomonas vaginalis set domain proteins, putative 0.0525 0.2978 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0074
Brugia malayi sulfakinin receptor protein 0.0048 0.016 0.0298
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Brugia malayi ThiF family protein 0.0058 0.0222 0.0415
Toxoplasma gondii hypothetical protein 0.0058 0.0222 0.3585
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.0073 0.013
Brugia malayi hypothetical protein 0.0024 0.0021 0.0029
Schistosoma mansoni hypothetical protein 0.0077 0.0335 0.0662
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0044 0.0065
Schistosoma mansoni biogenic amine receptor 0.0048 0.016 0.0311
Brugia malayi Bromodomain containing protein 0.0095 0.0438 0.0831
Echinococcus multilocularis orexin receptor type 2 0.0048 0.016 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0142 0.0287
Echinococcus multilocularis FTZ F1 alpha 0.0046 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi ORL1-like opioid receptor 0.0048 0.016 0.0298
Brugia malayi neuropeptide F receptor 0.0048 0.016 0.0298
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0032 0.0067 0.0118
Echinococcus multilocularis lamin 0.0033 0.007 0.0065
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Onchocerca volvulus Bile acid receptor homolog 0.0046 0.0148 0.0471
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0882 0.1761
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0261 0.0555
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Chlamydia trachomatis endonuclease IV 0.0093 0.0424 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.0653 0.2431
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0091 0.0085
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0215 0.0421
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.016 0.0298
Echinococcus granulosus peptide allatostatin:somatostatin 0.0048 0.016 0.0311
Echinococcus granulosus neuropeptide receptor 0.0048 0.016 0.0311
Schistosoma mansoni DNA helicase recq5 0.0035 0.0082 0.0154
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.016 0.0311
Echinococcus multilocularis fmrfamide receptor 0.0048 0.016 0.0155
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0035 0.0082 0.1003
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Brugia malayi Dopamine receptor protein 1 0.0048 0.016 0.0298
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0101 0.0193
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0647 0.1605
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0079 0.0345 0.0831
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0335 0.0662
Brugia malayi MH2 domain containing protein 0.0026 0.0029 0.0045
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0148 0.0143
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0732 0.1825
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni opsin-like receptor 0.0048 0.016 0.0311
Brugia malayi MH1 domain containing protein 0.0026 0.0029 0.0045
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Treponema pallidum licC protein (licC) 0.0125 0.0618 0.2302
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0046 0.0148 0.0287
Plasmodium vivax ubiquitin activating enzyme, putative 0.0058 0.0222 0.4671
Trichomonas vaginalis DNA helicase recq, putative 0.0038 0.0101 0.0046
Schistosoma mansoni biogenic amine (5HT) receptor 0.0299 0.1641 0.3289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0091 0.0163
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0038 0.0104 0.0198
Schistosoma mansoni opsin-like receptor 0.0048 0.016 0.0311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.1828 0.3663
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi nuclear receptor NHR-88 0.0046 0.0148 0.0274
Echinococcus granulosus tachykinin peptides receptor 99D 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0462 0.2602 0.4991
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0029 0.0023
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0896 0.1988
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0165 0.085 0.1699
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0329 0.065
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Brugia malayi mbt repeat family protein 0.0058 0.0218 0.0408
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0349 0.069
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0046 0.0148 0.0274
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Brugia malayi nuclear hormone receptor 0.0046 0.0148 0.0274
Onchocerca volvulus Peroxidase homolog 0.0032 0.0066 0.0198
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0124
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0046 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Brugia malayi Pre-SET motif family protein 0.0462 0.2602 0.4991
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0048 0.016 0.0311
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0646
Echinococcus granulosus lamin 0.0033 0.007 0.013
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0684 0.3914 1
Brugia malayi 6-phosphofructokinase 0.0131 0.0653 0.1244
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Brugia malayi Latrophilin receptor protein 2 0.0286 0.1564 0.2997
Loa Loa (eye worm) TAR-binding protein 0.0281 0.1534 0.2939
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0082 0.0361 0.0684
Echinococcus multilocularis neuropeptide receptor 0.0048 0.016 0.0155
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.0147
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0287 0.0566
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.1828 0.3663
Echinococcus multilocularis fmrfamide receptor 0.0048 0.016 0.0155
Echinococcus multilocularis ecdysone induced protein 78C 0.0046 0.0148 0.0143
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus granulosus neuropeptide receptor 0.0048 0.016 0.0311
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0653 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.033 0.1828 0.1823
Brugia malayi hypothetical protein 0.0036 0.0089 0.0161
Echinococcus multilocularis tar DNA binding protein 0.0281 0.1534 0.1529
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0073 0.0308 0.0764
Echinococcus granulosus orexin receptor type 2 0.0048 0.016 0.0311
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0218 0.0213
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0349 0.069
Leishmania major C-8 sterol isomerase-like protein 0.0775 0.4447 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.016 0.0311
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0091 0.0176
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0091 0.0176
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0096 0.0207
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0119 0.0228
Echinococcus granulosus g protein coupled receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Trypanosoma brucei trypanothione reductase 0.0057 0.0215 0.0451
Echinococcus multilocularis muscleblind protein 0.0149 0.0759 0.0754
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0684 0.3914 1
Leishmania major eukaryotic translation initiation factor-like 0.0042 0.0124 0.0245
Schistosoma mansoni thyroid hormone receptor 0.0198 0.1045 0.209
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Brugia malayi RE15519p 0.0048 0.016 0.0298
Leishmania major ubiquitin-activating enzyme-like protein 0.0038 0.0104 0.0201
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.203 0.4545
Loa Loa (eye worm) acetylcholinesterase 1 0.0082 0.0361 0.0684
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0775 0.4447 0.854
Onchocerca volvulus Neuropeptide F receptor homolog 0.0048 0.016 0.0511
Brugia malayi translation initiation factor 4E 0.0042 0.0124 0.0227
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0029 0.0047
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.008 0.0349 0.066
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0286 0.1564 0.2997
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0096 0.0182
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0151 0.0291
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0091 0.017
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0046 0.0148 0.0287
Brugia malayi AKH receptor 0.0048 0.016 0.0298
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0215 0.021
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.016 0.0311
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0349 0.0343
Mycobacterium ulcerans hypothetical protein 0.0036 0.0091 0.0193
Brugia malayi GnHR receptor homolog 0.0048 0.016 0.0298
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0308 0.0661
Loa Loa (eye worm) acetyltransferase 0.0178 0.0928 0.1773
Brugia malayi Steroid receptor seven-up type 2 0.0046 0.0148 0.0274
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0134 0.0269
Toxoplasma gondii hypothetical protein 0.0059 0.0225 0.3643
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0247 0.0523
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0042 0.0124 0.0118
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.016 0.0155
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0079 0.0345 0.0847
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Onchocerca volvulus 0.0048 0.016 0.0511
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0096 0.1361
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) MH2 domain-containing protein 0.0375 0.2091 0.401
Onchocerca volvulus 0.0525 0.2978 0.9817
Echinococcus granulosus tar DNA binding protein 0.0281 0.1534 0.3073
Echinococcus multilocularis dna polymerase kappa 0.0073 0.0308 0.0303
Onchocerca volvulus 0.0048 0.016 0.0511
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0093 0.0424 0.1034
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0038 0.0104 0.0201
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0647 0.1605
Onchocerca volvulus 0.0033 0.007 0.0214
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0287 0.0566
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0025 0.0038
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0046 0.0148 0.0287
Echinococcus granulosus G protein coupled receptor 139 0.0048 0.016 0.0311
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0029 0.0023
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0046 0.0148 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0148 0.0274
Brugia malayi steroid hormone receptor 0.0046 0.0148 0.0274
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0218 0.0427
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Trichomonas vaginalis bromodomain-containing protein, putative 0.0054 0.0199 0.0385
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.016 0.0298
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0259 0.0488
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0335 0.0662
Schistosoma mansoni sodium-dependent amino acid transporter 0.008 0.0349 0.069
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0119 0.0218
Brugia malayi hypothetical protein 0.0028 0.0044 0.0074
Mycobacterium ulcerans hypothetical protein 0.0024 0.0022 0.0017
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.016 0.0298
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0048 0.016 0.0155
Echinococcus granulosus dna polymerase kappa 0.0073 0.0308 0.0608
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.004 0.0112 0.0204
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0024 0.0022 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0091 0.0176
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0148 0.0287
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0178 0.0928 0.0922
Brugia malayi Peroxidasin 0.0032 0.0066 0.0115
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.203 0.4545
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Onchocerca volvulus 0.008 0.0349 0.1133
Treponema pallidum quinoline 2-oxidoreductase 0.0027 0.0036 0.0093
Loa Loa (eye worm) hypothetical protein 0.0053 0.0194 0.0362
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Onchocerca volvulus 0.0032 0.0066 0.0198
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0349 0.069
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0046 0.0148 0.0471
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0047 0.0153 0.2865
Echinococcus granulosus uncharacterized sodium dependent transporter 0.008 0.0349 0.069
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0119 0.0218
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0087 0.039 0.0385
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Trichomonas vaginalis DNA helicase recq, putative 0.005 0.0172 0.0291
Loa Loa (eye worm) hypothetical protein 0.047 0.265 0.5084
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0112 0.1783
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0046 0.0148 0.0274
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Onchocerca volvulus 0.0066 0.0269 0.087
Giardia lamblia DINP protein human, muc B family 0.0049 0.0166 1
Onchocerca volvulus 0.0036 0.0091 0.028
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0265 0.0522
Loa Loa (eye worm) runx1 0.0067 0.0274 0.0516
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0046 0.0152 0.0281
Loa Loa (eye worm) inositol-1 0.0037 0.0096 0.0174
Echinococcus multilocularis dro:myosuppressin receptor 0.0048 0.016 0.0155
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.008 0.0349 0.0343
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0088 0.1415
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0775 0.4447 1
Echinococcus multilocularis carboxylesterase 5A 0.0082 0.0361 0.0356
Echinococcus multilocularis musashi 0.0033 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0535 0.3033 0.5821
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0287 0.0681
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0215 0.0496
Echinococcus granulosus dro:myosuppressin receptor 0.0048 0.016 0.0311
Brugia malayi 6-phosphofructokinase 0.0131 0.0653 0.1244
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0215 0.4499
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0046 0.0148 0.0274
Mycobacterium ulcerans glutaminase 0.0317 0.1747 0.4442
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0148 0.0274
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0029 0.0045
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0218 0.0427
Loa Loa (eye worm) hypothetical protein 0.0072 0.03 0.0567
Mycobacterium ulcerans hypothetical protein 0.0125 0.0618 0.1547
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0091 0.0171
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0048 0.016 0.0311
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0589 0.0584
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0046 0.0148 0.0143
Leishmania major DNA polymerase eta, putative 0.0072 0.03 0.0643
Brugia malayi Serotonin receptor 0.0048 0.016 0.0298
Brugia malayi hypothetical protein 0.008 0.0349 0.066
Schistosoma mansoni coup transcription factor 0.0046 0.0148 0.0287
Loa Loa (eye worm) hypothetical protein 0.0149 0.0759 0.1448
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0048 0.016 0.0511
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0096 0.0182
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0067 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0046 0.0148 0.0274
Schistosoma mansoni hypothetical protein 0.0618 0.3521 0.7068
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0096 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0269 0.0529
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Brugia malayi intermediate filament protein 0.0033 0.007 0.0124
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0096 0.0151
Mycobacterium tuberculosis Conserved hypothetical protein 0.0125 0.0618 0.1532
Brugia malayi G-protein coupled receptor 0.0048 0.016 0.0298
Onchocerca volvulus 0.0048 0.016 0.0511
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.008 0.0349 0.069
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Calcitonin receptor-like protein seb-1 0.0903 0.5207 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0329 0.0323
Echinococcus granulosus g-protein coupled receptor 0.0048 0.016 0.0311
Schistosoma mansoni smad1 5 8 and 0.0026 0.0029 0.0047
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0048 0.016 0.0298
Brugia malayi beta-lactamase 0.0036 0.0091 0.0163
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0265 0.0522
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0653 1
Trichomonas vaginalis esterase, putative 0.0036 0.0091 0.0011
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Onchocerca volvulus 0.0048 0.016 0.0511
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0349 0.0659
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Onchocerca volvulus 0.0048 0.016 0.0511
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0349 0.0752
Onchocerca volvulus 0.0036 0.0091 0.028
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.133
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0015 0.0018
Echinococcus granulosus sex peptide receptor 0.0048 0.016 0.0311
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0044 0.0065
Onchocerca volvulus 0.0032 0.0066 0.0198
Onchocerca volvulus 0.0048 0.016 0.0511
Loa Loa (eye worm) hypothetical protein 0.0058 0.0218 0.0408
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.016 0.0311
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0021 0.0031
Loa Loa (eye worm) blistered cuticle protein 3 0.0032 0.0066 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0361 0.0356
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0096 0.0182
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0775 0.077
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0046 0.0148 0.0274
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.1234 0.3115
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0101 0.0193
Onchocerca volvulus 0.047 0.265 0.8734
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0093 0.0424 0.0805
Onchocerca volvulus Peroxidasin homolog 0.0032 0.0066 0.0198
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0155
Mycobacterium ulcerans hypothetical protein 0.0027 0.0039 0.0062
Toxoplasma gondii ThiF family protein 0.0038 0.0104 0.1686
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0218 0.0408
Echinococcus granulosus uncharacterized sodium dependent transporter 0.008 0.0349 0.069
Plasmodium vivax hypothetical protein, conserved 0.008 0.0349 0.8015
Brugia malayi Melatonin receptor type 1A 0.0048 0.016 0.0298
Plasmodium falciparum glutathione reductase 0.0057 0.0215 0.4499
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.203 0.4545
Onchocerca volvulus 0.0033 0.007 0.0214
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0091 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0148 0.0274
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.008 0.0349 0.069
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0046 0.0148 0.0287
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.0199 0.4069
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0287 0.0697
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0148 0.0143
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0653 1
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0215 0.0403
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.016 0.0155
Echinococcus multilocularis dna polymerase eta 0.0072 0.03 0.0295
Echinococcus multilocularis allatostatin A receptor 0.0048 0.016 0.0155
Schistosoma mansoni hypothetical protein 0.0865 0.4979 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.0653 0.162
Leishmania major trypanothione reductase 0.0057 0.0215 0.0451
Trichomonas vaginalis glutaminase, putative 0.0317 0.1747 0.5742
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0168 0.0869 0.2704
Toxoplasma gondii exonuclease III APE 0.0037 0.0096 0.155
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.016 0.0155
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0048 0.016 0.0155
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0349 0.0659
Echinococcus granulosus geminin 0.0865 0.4979 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0101 0.0193
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0732 0.1825
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0287 0.0281
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0088 0.1142
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0134 0.2174
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0046 0.0148 0.0274
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.133
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni lozenge 0.0067 0.0274 0.054
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0424 1
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0125 0.0618 0.1547
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0589 0.1173
Echinococcus granulosus ecdysone induced protein 78C 0.0046 0.0148 0.0287
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0155
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0349 0.069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0148 0.0274
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0148 0.0287
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0349 0.0343
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0042 0.0124 0.0245
Brugia malayi nuclear receptor RXR 0.0024 0.0021 0.0029
Loa Loa (eye worm) MBCTL1 0.0066 0.0265 0.0499
Echinococcus granulosus lamin dm0 0.0033 0.007 0.013
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0134 0.0129
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0589 0.1173
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0035 0.0082 0.0154
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Brugia malayi hypothetical protein 0.0535 0.3033 0.5821
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0096 0.003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0096 0.0173
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0178 0.0928 0.1854
Echinococcus granulosus intermediate filament protein 0.0033 0.007 0.013
Brugia malayi follicle stimulating hormone receptor 0.0048 0.016 0.0298
Loa Loa (eye worm) carboxylesterase 0.0082 0.0361 0.0684
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0079 0.0345 0.0847
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Brugia malayi acetyltransferase, GNAT family protein 0.0178 0.0928 0.1773
Brugia malayi Serotonin receptor 0.0048 0.016 0.0298
Schistosoma mansoni opsin-like receptor 0.0048 0.016 0.0311
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.008 0.0349 0.069
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0119 0.0228
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.016 0.0298
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.016 0.0311
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.008 0.0349 0.0343
Loa Loa (eye worm) solute carrier family 6 member 4 0.047 0.265 0.5084
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.016 0.0311
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.0653 0.1635
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0119 0.0113
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0775 0.1547
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0361 0.0356
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0684 0.3914 1
Loa Loa (eye worm) translation initiation factor 4E 0.0042 0.0124 0.0227
Brugia malayi Dopamine receptor protein 2 0.0048 0.016 0.0298
Onchocerca volvulus 0.0535 0.3033 1
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0032 0.0067 0.0117
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.03 0.0643
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0096 0.003
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0653 0.1438
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0349 0.0689
Leishmania major hypothetical protein, conserved 0.0028 0.0044 0.0065
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.03 0.0567
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.033 0.1828 0.3503
Schistosoma mansoni inositol monophosphatase 0.0037 0.0096 0.0182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.016 0.0311
Echinococcus multilocularis somatostatin receptor 0.0048 0.016 0.0155
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.007 0.0124
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0349 0.069
Brugia malayi beta-lactamase family protein 0.0036 0.0091 0.0163
Loa Loa (eye worm) hypothetical protein 0.0299 0.1641 0.3145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0046 0.0148 0.0274
Treponema pallidum sodium- and chloride- dependent transporter 0.047 0.265 1
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0112 0.0106
Brugia malayi TAR-binding protein 0.0281 0.1534 0.2939
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0021 0.0015
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0181 0.0374
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0096 0.0173
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0112 0.0204
Brugia malayi Sodium:neurotransmitter symporter family protein 0.047 0.265 0.5084
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0046 0.0148 0.0287
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.016 0.0311
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0039 0.0067
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0349 0.0689
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0181 0.0374
Trypanosoma brucei unspecified product 0.0028 0.0044 0.0065
Onchocerca volvulus 0.0036 0.0091 0.028
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.0653 0.0647
Schistosoma mansoni ap endonuclease 0.0037 0.0096 0.0181
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0077 0.0137
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0096 0.0029
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0119 0.0555
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.0653 0.1438
Loa Loa (eye worm) hypothetical protein 0.0396 0.2213 0.4245
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0287 0.0541
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0215 0.0451
Mycobacterium ulcerans hypothetical protein 0.0192 0.1011 0.2555
Echinococcus multilocularis serotonin receptor 0.0299 0.1641 0.1637
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.005 0.0172 0.0402
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0049 0.0166 0.034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.039 0.0774
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.039 0.0774
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.007 0.0124
Mycobacterium ulcerans endonuclease IV 0.0093 0.0424 0.1049
Echinococcus granulosus serotonin receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0029 0.0045
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0039 0.0067
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.016 0.0311
Schistosoma mansoni inositol monophosphatase 0.0037 0.0096 0.0182
Echinococcus granulosus fmrfamide receptor 0.0048 0.016 0.0311
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.008 0.0349 0.069
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Brugia malayi Pre-SET motif family protein 0.0066 0.0269 0.0506
Brugia malayi hypothetical protein 0.0032 0.0066 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0234 0.1261 0.1256
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0053 0.019 0.0371
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0148 0.0287
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0181 0.0374
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0218 0.0213
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0096 0.009
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0157 0.296
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0054 0.0199 0.0385
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0057 0.0213 0.049
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi glutathione reductase 0.0057 0.0215 0.0403
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0148 0.0287
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0147
Schistosoma mansoni hypothetical protein 0.004 0.0112 0.0214
Echinococcus granulosus bloom syndrome protein 0.005 0.0172 0.0333
Brugia malayi Carboxylesterase family protein 0.0082 0.0361 0.0684
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0088 0.1415
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus granulosus alpha 1A adrenergic receptor 0.0048 0.016 0.0311
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0286 0.1564 0.1559
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0091 0.0176
Schistosoma mansoni smad1 5 8 and 0.0026 0.0029 0.0047
Trichomonas vaginalis aldehyde oxidase, putative 0.0168 0.0869 0.2704
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0112 0.0204
Onchocerca volvulus Protein ultraspiracle homolog 0.0046 0.0148 0.0471
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Schistosoma mansoni blooms syndrome DNA helicase 0.0032 0.0068 0.0124
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0021 0.0029
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0589 0.1173
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0024 0.0022 0.0054
Plasmodium vivax glutathione reductase, putative 0.0057 0.0215 0.4499
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0045 0.0142 0.0263
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0286 0.1564 0.3134
Loa Loa (eye worm) hypothetical protein 0.0775 0.4447 0.854
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0166 0.034
Mycobacterium ulcerans beta-lactamase 0.0036 0.0091 0.0193
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.016 0.0298
Brugia malayi MH2 domain containing protein 0.0026 0.0029 0.0045
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0035 0.0082 0.0077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.033 0.1828 0.3663
Echinococcus granulosus GPCR family 2 0.0286 0.1564 0.3134
Brugia malayi Carboxylesterase family protein 0.0082 0.0361 0.0684
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.0308 0.0752
Onchocerca volvulus 0.0048 0.016 0.0511
Brugia malayi hypothetical protein 0.0024 0.0021 0.0029
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0589 0.1471
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0096 0.1361
Entamoeba histolytica recQ family helicase, putative 0.0038 0.0101 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0011
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0096 0.009
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0057 0.0213 0.0507
Leishmania major hypothetical protein, conserved 0.0036 0.0091 0.017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0286 0.1564 0.1559
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.016 0.0298
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0038 0.0104 0.0198
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0011
Schistosoma mansoni adenoreceptor 0.0048 0.016 0.0311
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0021 0.0031
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Toxoplasma gondii thioredoxin reductase 0.0057 0.0215 0.3479
Echinococcus multilocularis bloom syndrome protein 0.005 0.0172 0.0166
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.0653 0.1301
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Onchocerca volvulus 0.0032 0.0066 0.0198
Plasmodium vivax SET domain protein, putative 0.0066 0.0269 0.5914
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.016 0.0311
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0088 0.1142
Brugia malayi MH1 domain containing protein 0.0026 0.0029 0.0045
Brugia malayi Blistered cuticle protein 3 0.0032 0.0066 0.0115
Echinococcus granulosus smad 0.0026 0.0029 0.0047
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0589 0.1471
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus granulosus histone lysine methyltransferase setb 0.0087 0.039 0.0774
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0054 0.0199 0.3215
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0349 0.069
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Echinococcus multilocularis lamin dm0 0.0033 0.007 0.0065
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0049 0.0794
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus granulosus serotonin transporter 0.047 0.265 0.5317
Schistosoma mansoni peroxidasin 0.0032 0.0066 0.012
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0589 0.1471
Brugia malayi hypothetical protein 0.0036 0.0089 0.0161
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0044 0.0713
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0218 0.0427
Plasmodium falciparum amino acid transporter, putative 0.008 0.0349 0.8015
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0042 0.0124 0.0245
Brugia malayi Inositol-1 0.0037 0.0096 0.0174
Toxoplasma gondii hypothetical protein 0.008 0.0349 0.5641
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0234 0.1261 0.2524
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Onchocerca volvulus Peroxidasin homolog 0.0032 0.0066 0.0198
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0029 0.0047
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0021 0.0031
Echinococcus granulosus acetylcholinesterase 0.0082 0.0361 0.0715
Onchocerca volvulus 0.008 0.0349 0.1133
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0031
Loa Loa (eye worm) hypothetical protein 0.0087 0.039 0.074
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.1828 0.3663
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.016 0.0298
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0111 0.0535 0.1332
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0127
Echinococcus granulosus acetylcholinesterase 0.0082 0.0361 0.0715
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Echinococcus multilocularis neuropeptide FF receptor 2 0.0048 0.016 0.0155
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0053 0.0236
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0647 0.1605
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0119 0.0228
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0286 0.1564 0.3134
Loa Loa (eye worm) hypothetical protein 0.0066 0.0265 0.0499
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni thyroid hormone receptor 0.0198 0.1045 0.209
Schistosoma mansoni zinc finger protein 0.0028 0.0043 0.0075
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Dopamine receptor 0.0048 0.016 0.0298
Schistosoma mansoni Smad4 0.0026 0.0029 0.0047
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0035 0.0082 0.0077
Onchocerca volvulus Chorion peroxidase homolog 0.0032 0.0066 0.0198
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0535 0.3033 0.5821
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0349 0.069
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.5641
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0589 0.1294
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0073 0.0132
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0042 0.0124 0.2005
Brugia malayi Cytochrome P450 family protein 0.0023 0.0015 0.0018
Brugia malayi hypothetical protein 0.0077 0.0335 0.0633
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0039 0.0033
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.0653 0.162
Echinococcus granulosus neuropeptide FF receptor 2 0.0048 0.016 0.0311
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.033 0.1828 0.3503
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.016 0.0298
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0653 0.1244
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0088 0.1142
Toxoplasma gondii ABC1 family protein 0.0036 0.0091 0.1465
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0091 0.0193
Loa Loa (eye worm) hypothetical protein 0.0082 0.0361 0.0684
Schistosoma mansoni glutaminase 0.0317 0.1747 0.3501
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0311
Brugia malayi Bloom's syndrome protein homolog 0.005 0.0172 0.0319
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Trypanosoma brucei C-8 sterol isomerase, putative 0.0775 0.4447 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Loa Loa (eye worm) hypothetical protein 0.047 0.265 0.5084
Echinococcus granulosus carboxylesterase 5A 0.0082 0.0361 0.0715
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.033 0.1828 0.1823
Mycobacterium ulcerans hypothetical protein 0.0125 0.0618 0.1547
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.203 0.4545
Loa Loa (eye worm) hypothetical protein 0.0286 0.1564 0.2997
Brugia malayi Cytochrome P450 family protein 0.0023 0.0015 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0142 0.0287
Echinococcus granulosus g protein coupled receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) latrophilin receptor protein 2 0.0286 0.1564 0.2997
Mycobacterium ulcerans epimerase 0.0024 0.0022 0.0017
Echinococcus multilocularis g-protein coupled receptor 0.0048 0.016 0.0155
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0349 0.069
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0287 0.0613
Echinococcus multilocularis G-protein coupled receptor, putative 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0299 0.1641 0.3145
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Leishmania major DNA polymerase eta, putative 0.0043 0.0134 0.0269
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0141 0.0708 0.0703
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.016 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0046 0.0148 0.0274
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.016 0.0311
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.0583 0.0578
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) transcription factor SMAD2 0.0375 0.2091 0.401
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0287 0.0697
Onchocerca volvulus 0.0048 0.016 0.0511
Schistosoma mansoni hypothetical protein 0.0152 0.0775 0.1547
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0653 0.1244
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Onchocerca volvulus 0.0048 0.016 0.0511
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.016 0.0311
Mycobacterium tuberculosis Probable reductase 0.013 0.0647 0.1605
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0046 0.0148 0.0274
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.016 0.0298
Onchocerca volvulus 0.0048 0.016 0.0511
Treponema pallidum hypothetical protein 0.0027 0.0039 0.0108
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.016 0.0298
Echinococcus multilocularis g protein coupled receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Loa Loa (eye worm) ThiF family protein 0.0038 0.0104 0.019
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Toxoplasma gondii endonuclease IV APN 0.0093 0.0424 0.6861
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0653 0.1301
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0015 0.0018
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0048 0.016 0.0155
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0038 0.0104 0.1583
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0046 0.0148 0.0274
Brugia malayi G-protein coupled receptor 0.0048 0.016 0.0298
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0096 0.1626
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0096 0.0322
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0903 0.5207 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0096 0.1554
Trypanosoma brucei unspecified product 0.0028 0.0044 0.0065
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0038 0.0104 0.0099
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0057 0.0213 0.0507
Echinococcus multilocularis thyroid hormone receptor alpha 0.0198 0.1045 0.104
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Brugia malayi Smad1 0.0026 0.0029 0.0045
Brugia malayi latrophilin 2 splice variant baaae 0.0618 0.3521 0.6758
Echinococcus granulosus hypothetical protein 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0093 0.0424 0.0805
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis g protein coupled receptor 0.0048 0.016 0.0155
Onchocerca volvulus Peroxidase homolog 0.0032 0.0066 0.0198
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus allatostatin A receptor 0.0048 0.016 0.0311
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.016 0.0311
Brugia malayi PHD-finger family protein 0.0034 0.0081 0.0145
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0042 0.0124 0.0238
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0255 0.05
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0157 0.8895
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0011
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0096 0.0207
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0589 0.1457
Toxoplasma gondii hypothetical protein 0.008 0.0349 0.5641
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0091 0.0171
Brugia malayi photoreceptor-specific nuclear receptor 0.0046 0.0148 0.0274
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Schistosoma mansoni biogenic amine receptor 0.0048 0.016 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0265 0.0499
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0058 0.0222 0.0434
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0281 0.1534 0.2939
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.016 0.0298
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0042 0.0124 0.0245
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0265 0.026
Brugia malayi neuropeptide F receptor 0.0048 0.016 0.0298
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0042 0.0124 0.0238
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0091 0.0011
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.016 0.0311
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.016 0.0298
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0112 0.0204
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0046 0.0148 0.0287
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0091 0.0171
Brugia malayi beta-lactamase family protein 0.0036 0.0091 0.0163
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.016 0.0155
Brugia malayi Cytochrome P450 family protein 0.0034 0.0077 0.0137
Trichomonas vaginalis DNA polymerase eta, putative 0.0073 0.0308 0.0764
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Echinococcus multilocularis smad 0.0026 0.0029 0.0023
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0058 0.0222 0.0415
Onchocerca volvulus 0.0048 0.016 0.0511
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus Smad4 0.0026 0.0029 0.0047
Echinococcus granulosus 7tm_1 domain containing protein 0.0048 0.016 0.0311
Schistosoma mansoni histamine h1 receptor 0.0048 0.016 0.0311
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0035 0.0082 0.0154
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0046 0.0148 0.0287
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.016 0.0298
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.016 0.0311
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0091 0.0011
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0091 0.0193
Loa Loa (eye worm) phosphofructokinase 0.0131 0.0653 0.1244
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0038 0.0104 0.0201
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0896 0.1988
Schistosoma mansoni amine GPCR 0.0448 0.252 0.5055
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0349 0.069
Loa Loa (eye worm) hypothetical protein 0.0149 0.0759 0.1448
Brugia malayi larval opioid receptor 0.0048 0.016 0.0298
Brugia malayi RNA recognition motif domain containing protein 0.0281 0.1534 0.2939
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0265 0.026
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0112 0.1809
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0096 0.0182
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0218 0.0427
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0269 0.0529
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0091 0.017
Loa Loa (eye worm) intermediate filament protein 0.0033 0.007 0.0124
Loa Loa (eye worm) RecQ helicase 0.005 0.0172 0.0319
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0091 0.017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus granulosus somatostatin receptor 0.0048 0.016 0.0311
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0647 0.1605
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0093 0.0424 0.1034
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni biogenic amine receptor 0.0048 0.016 0.0311
Onchocerca volvulus 0.0058 0.0218 0.0702
Brugia malayi Bromodomain containing protein 0.0051 0.0176 0.0328
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0096 0.0181
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0046 0.0148 0.0287
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0732 0.1825
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0046 0.0148 0.0143
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0015 0.0018
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0653 0.1438
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0046 0.0148 0.0274
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.016 0.0298
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0048 0.016 0.0155
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0653 0.1301
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0349 0.0752
Schistosoma mansoni intermediate filament proteins 0.0033 0.007 0.013
Brugia malayi ThiF family protein 0.0038 0.0104 0.019
Schistosoma mansoni lamin 0.0033 0.007 0.013
Schistosoma mansoni sodium/chloride dependent transporter 0.047 0.265 0.5317
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0046 0.0148 0.0274
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0091 0.1223
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0269 0.4349
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0903 0.5207 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0035 0.0082 0.0147
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0091 0.0176
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0349 0.0752
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.008 0.0349 0.7759
Brugia malayi phosphofructokinase 0.0131 0.0653 0.1244
Loa Loa (eye worm) steroid hormone receptor 0.0046 0.0148 0.0274
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0349 0.069
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.0199 0.0388
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0349 0.0752
Echinococcus granulosus peroxidasin 0.0032 0.0066 0.012
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0647 0.1605
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0067 0.0134
Schistosoma mansoni ap endonuclease 0.0037 0.0096 0.0181
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1011 0.2542
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0684 0.3914 1
Loa Loa (eye worm) norepinephrine transporter 0.047 0.265 0.5084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Echinococcus granulosus muscleblind protein 0.0149 0.0759 0.1514
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0732 0.1825
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0148 0.0274
Schistosoma mansoni bromodomain containing protein 0.0081 0.0354 0.0701
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0049 0.0166 0.037
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0046 0.0148 0.0274
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Echinococcus granulosus biogenic amine 5HT receptor 0.0299 0.1641 0.3289
Trypanosoma brucei unspecified product 0.0065 0.0261 0.0555
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.008 0.0349 0.0343
Schistosoma mansoni peroxidasin 0.0032 0.0066 0.012
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0042 0.0124 0.0245
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0058 0.0222 0.4671
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0038 0.0104 0.1583
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0054 0.0199 0.3215
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.0147
Loa Loa (eye worm) RNA binding protein 0.0281 0.1534 0.2939
Echinococcus multilocularis serotonin receptor 0.0299 0.1641 0.1637
Brugia malayi ecdysteroid receptor 0.0046 0.0148 0.0274
Brugia malayi MH2 domain containing protein 0.0375 0.2091 0.401
Loa Loa (eye worm) glutaminase 2 0.0317 0.1747 0.3348
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0046 0.0148 0.0287
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0029 0.0047
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0176
Loa Loa (eye worm) glutaminase 0.0317 0.1747 0.3348
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Echinococcus granulosus FTZ F1 alpha 0.0046 0.0148 0.0287
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.016 0.0298
Echinococcus multilocularis neuropeptide receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.016 0.0298
Trichomonas vaginalis DNA helicase recq1, putative 0.005 0.0172 0.0291
Echinococcus multilocularis neuropeptide s receptor 0.0048 0.016 0.0155
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.047 0.265 0.5317
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Brugia malayi mbt repeat family protein 0.0058 0.0218 0.0408
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0335 0.0329
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Onchocerca volvulus 0.0048 0.016 0.0511
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0096 0.019
Echinococcus multilocularis Protein lozenge 0.0067 0.0274 0.0269
Loa Loa (eye worm) beta-lactamase 0.0036 0.0091 0.0163
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0647 0.1605
Echinococcus multilocularis geminin 0.0865 0.4979 0.4976
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0181 0.0374
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0048 0.016 0.0155
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Plasmodium vivax amine transporter, putative 0.008 0.0349 0.8015
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0265 0.0522
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0896 0.1988
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.016 0.0311
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0073 0.0132
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.016 0.0311
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0311
Loa Loa (eye worm) serotonin transporter b 0.047 0.265 0.5084
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0151 0.0145
Schistosoma mansoni myosin xvIII 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.5641
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0349 0.4619
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Echinococcus granulosus g protein coupled receptor 0.0048 0.016 0.0311
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0088 0.0629
Mycobacterium tuberculosis Conserved hypothetical protein 0.0125 0.0618 0.1532
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0088 0.029
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0589 0.9523
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0218 0.0702
Echinococcus granulosus zinc finger protein 0.0028 0.0043 0.0075
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0091 0.0176
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.5641
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0308 0.0661
Echinococcus granulosus neuropeptide s receptor 0.0048 0.016 0.0311
Schistosoma mansoni hypothetical protein 0.0025 0.0025 0.0039
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0058 0.0222 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Activation of rat PXR expressed in human HepG2 cells up to 46 uM after 24 hrs by luciferase reporter gene based luminescent analysis ChEMBL. 20966043
Activity (binding) Induction of human myc epitope-tagged GLUT1 translocation to plasma membrane overexpressed in rat L6 cells at 2 mM after 30 mins by immunocolorimetric analysis in presence of 23.5 mM D-glucose ChEMBL. 23984871
Activity (binding) < 5 % Inhibition of human AchE-induced amyloid beta aggregation at 100 uM ChEMBL. 18181565
Activity (functional) = 5.2 % Antioxidant activity assessed as DPPH reducing activity at 0.5 mM after 20 mins ChEMBL. 17444626
Activity (functional) = 6.8 % Antioxidant activity assessed as DPPH reducing activity at 0.5 mM after 60 mins ChEMBL. 17444626
Activity (functional) = 19.2 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at S phase at 100 uM after 24 hrs by flow cytometry (Rvb = 21+/-0.9%) ChEMBL. 21111517
Activity (functional) = 19.3 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at S phase at 300 uM after 24 hrs by flow cytometry (Rvb = 21+/-0.9%) ChEMBL. 21111517
Activity (functional) = 20.1 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at S phase at 150 uM after 24 hrs by flow cytometry (Rvb = 21+/-0.9%) ChEMBL. 21111517
Activity (functional) = 20.3 % Antioxidant activity assessed as DPPH reducing activity at 0.1 mM after 20 mins ChEMBL. 17444626
Activity (functional) = 27.1 % Antioxidant activity assessed as DPPH reducing activity at 0.1 mM after 60 mins ChEMBL. 17444626
Activity (functional) = 32.1 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at G2/M phase at 150 uM after 24 hrs by flow cytometry (Rvb = 17.6+/-1%) ChEMBL. 21111517
Activity (functional) = 36.9 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at G2/M phase at 100 uM after 24 hrs by flow cytometry (Rvb = 17.6+/-1%) ChEMBL. 21111517
Activity (functional) = 37.5 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at G0/G1 phase at 300 uM after 24 hrs by flow cytometry (Rvb = 61.4+/-1.1%) ChEMBL. 21111517
Activity (functional) = 38.6 % Antioxidant activity assessed as DMSO hydroxyl radical scavenging activity at 0.1 mM ChEMBL. 17444626
Activity (functional) = 40.3 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at G2/M phase at 300 uM after 24 hrs by flow cytometry (Rvb = 17.6+/-1%) ChEMBL. 21111517
Activity (functional) = 43.5 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at G0/G1 phase at 100 uM after 24 hrs by flow cytometry (Rvb = 61.4+/-1.1%) ChEMBL. 21111517
Activity (functional) = 45.6 % Induction of cell cycle arrest in human HT-29 cells assessed as accumulation at G0/G1 phase at 150 uM after 24 hrs by flow cytometry (Rvb = 61.4+/-1.1%) ChEMBL. 21111517
Activity (functional) = 58.5 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 50 uM ChEMBL. 15658850
Activity (functional) = 65 % Induction of apoptosis in human SMMC7721 cells at 5 mM after 96 hrs ChEMBL. 20403695
Activity (functional) = 74.33 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 10 uM ChEMBL. 15658850
Activity (functional) = 79.5 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 5 uM ChEMBL. 15658850
Activity (functional) = 83 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 1 uM ChEMBL. 15658850
Activity (functional) = 86 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 0 uM ChEMBL. 15658850
Activity (functional) = 90.25 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 0.5 uM ChEMBL. 15658850
Activity (functional) = 91.25 % Percentage increase of intracellular reactive oxygen species in neuronal cells at 0.1 uM ChEMBL. 15658850
Arrhythmia score (functional) < 6.3 Effect on in vitro myocardial electrical activity (arrhythmia score) at 5 microM ChEMBL. 11708933
cLogP = 2.39 The compound was evaluated for lipophilicity. ChEMBL. 11708933
EC50 (ADMET) = 2.8 uM Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assay ChEMBL. 20966043
EC50 (functional) = 121.6 uM Ability of the compound for prevention of GSH depletion was measured in mouse ChEMBL. 12031315
EC50 (functional) = 250 uM Induction of apoptosis in human HT-29 cells ChEMBL. 20403695
Efficacy (ADMET) = 107.9 % Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assay relative to SR12813 ChEMBL. 20966043
GI (functional) = 0.14 % Cytotoxicity against human KB cells assessed as growth inhibition at 0.1 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 2.39 % Cytotoxicity against human NCI-H460 cells assessed as growth inhibition at 10 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 2.52 % Cytotoxicity against human Bel7402 cells assessed as growth inhibition at 1 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 4.65 % Cytotoxicity against human NCI-H460 cells assessed as growth inhibition at 1 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 4.77 % Cytotoxicity against human Bel7402 cells assessed as growth inhibition at 10 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 5.72 % Cytotoxicity against human NCI-H460 cells assessed as growth inhibition at 100 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 5.72 % Growth inhibition of Homo sapiens (human) NCI-H460 cells at 100 ug/ml by MTT assay ChEMBL. No reference
GI (functional) = 6.5 % Growth inhibition of human HT-29 cells at 100 uM after 48 hrs by BrdU-ELISA assay ChEMBL. 21111517
GI (functional) = 7.18 % Cytotoxicity against human KB cells assessed as growth inhibition at 10 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 8.17 % Cytotoxicity against human Bel7402 cells assessed as growth inhibition at 100 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 8.6 % Cytotoxicity against human KB cells assessed as growth inhibition at 1 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 8.71 % Cytotoxicity against human NCI-H460 cells assessed as growth inhibition at 0.1 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 10.96 % Cytotoxicity against human KB cells assessed as growth inhibition at 100 ug/ml after 24 hrs by MTT assay ChEMBL. 20403695
GI (functional) = 17.8 % Growth inhibition of human HT-29 cells at 100 uM after 24 hrs by BrdU-ELISA assay ChEMBL. 21111517
GI (functional) = 18.4 % Growth inhibition of human HT-29 cells at 150 uM after 48 hrs by BrdU-ELISA assay ChEMBL. 21111517
GI (functional) = 19.5 % Growth inhibition of human HT-29 cells at 300 uM after 48 hrs by BrdU-ELISA assay ChEMBL. 21111517
GI (functional) = 24 % Growth inhibition of human HT-29 cells at 300 uM after 24 hrs by BrdU-ELISA assay ChEMBL. 21111517
GI (functional) = 25.5 % Growth inhibition of human HT-29 cells at 150 uM after 24 hrs by BrdU-ELISA assay ChEMBL. 21111517
IC50 (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) Inhibition of bovine COX1 ChEMBL. 17976864
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
IC50 (binding) > 1 10'-3M Inhibition of human serum recombinant AChE after 20 mins using acetylthiocholine iodide as a substrate by Ellman's assay ChEMBL. 21924801
IC50 (binding) > 1 10'-3M Inhibition of human serum recombinant BChE after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assay ChEMBL. 21924801
IC50 (functional) > 0.4 mM Evaluated for the interaction with 0.2 mM of the stable free radical DPPH. ChEMBL. 11708933
IC50 (binding) = 1 nM Inhibition of human AchE ChEMBL. 18181565
IC50 (binding) > 1000000 nM Inhibitory concentration against human recombinant acetylcholinesterase ChEMBL. 15658850
IC50 (binding) > 1000000 nM Inhibitory concentration against human recombinant butyrylcholinesterase ChEMBL. 15658850
IC50 (binding) uM In vitro inhibition concentration of the compound was evaluated on the effect of conversion by Nitric Oxide synthase of [3H]-L-arginine into [3H]-L-citrulline; Not active up to 100 microM ChEMBL. 12031315
IC50 (binding) = 0 uM Inhibition of human COX2 ChEMBL. 17976864
IC50 (functional) = 19.6 uM Neuroprotective effect was measured by its ability to protect mouse hippocampal neuronal HT-22 cell lines from oxidative stress caused by glutamate ChEMBL. 12031315
IC50 (functional) = 54.86 uM Antioxidant activity against formation of ROS was determined in t-BuOOH treated LNCaP cells after 24 h of incubation with compounds (1-100 uM) ChEMBL. 15633998
IC50 (functional) > 100 uM Cytotoxicity against human MRC5 cells after 48 hrs by SRB assay ChEMBL. 25874330
IC50 (functional) > 1000 uM Inhibition of in vitro peroxidation (LP) of rat Hepatic microsomal membrane lipid ChEMBL. 11708933
Inhibition (binding) Inhibition of mushroom tyrosinase using L-DOPA as substrate at 2.5 mM preincubated for 10 to 15 mins prior to substrate addition by spectrophotometry ChEMBL. 24090916
Inhibition (functional) = 25.2 % Inhibition of nitrite level in LPS-induced mouse RAW264.7 cells at 5 uM by Griess assay relative to LPS treated control ChEMBL. 21183258
Inhibition (binding) = 29.1 % Inhibition of soybean lipoxygenase at 0.1 mM ChEMBL. 17444626
Inhibition (binding) = 29.1 % Inhibition of soybean lipoxygenase at 0.1 mM ChEMBL. 17444626
Inhibition (functional) = 29.6 % Inhibition of carrageenin-induced Fischer 344 rat paw edema at 0.01 mmol/kg, ip ChEMBL. 17444626
Inhibition (binding) < 30 % Inhibition of COX2 at 100 uM by scintillation proximity assay ChEMBL. 12444669
Inhibition (functional) = 50 % Growth inhibition of human FADU cells at 10 uM ChEMBL. 20403695
Inhibition (functional) = 50 % Growth inhibition of human SCC9 cells at 10 uM ChEMBL. 20403695
Inhibition (functional) = 50 % Growth inhibition of human SCC25 cells at 10 uM ChEMBL. 20403695
Inhibition (binding) = 76 % Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products at 500 uM preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method relative to control ChEMBL. 24088053
Inhibition (binding) = 95 % Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products at 500 uM preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method relative to control ChEMBL. 24088053
Inhibition (ADMET) = 103.3327209 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 129.0717504 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Kd (functional) > 5 Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoreceptor) ChEMBL. 15633998
Kd (functional) > 5 Blocking activity was assessed by antagonism of (-)-phenylephrine induced contraction of rat spleen (alpha1B adrenoreceptor) ChEMBL. 15633998
Kd (functional) > 5 Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (alpha1D adrenoreceptor) ChEMBL. 15633998
Ki (binding) DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
Log Ki (binding) Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]-prazosin to label cloned human alpha 1b expressed in CHO cells; Not tested ChEMBL. 15633998
Log Ki (binding) Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]-prazosin to label cloned human alpha 1a expressed in CHO cells; Not tested ChEMBL. 15633998
Log Ki (binding) Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]-prazosin to label cloned human alpha 1d expressed in CHO cells; Not tested ChEMBL. 15633998
MDA content (functional) < 1.03 uM (g of tissue)-1 Effect on in vitro accumulation of MDA content in heart, at conc of 5 microM ChEMBL. 11708933
MNCC (ADMET) = 0.1 mM Cytotoxicity against mouse B16F10 cells assessed as cell viability after 48 hrs by MTT assay ChEMBL. 24090916
Potency (functional) 0.2512 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV. (Class of assay: confirmatory) [Related pubchem assays: 1705, 1707 ] ChEMBL. No reference
Potency (functional) 0.8913 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.6109 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8024 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen)] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS Validation Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) = 33.8078 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Human Peripheral Myelin Protein 22 (PMP22) Expression/Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: Validation of Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.6858 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23
Homo sapiens ChEMBL23 12031315

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

39 literature references were collected for this gene.

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